Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses

Science Translational Medicine

Volumn 9, Issue 396, 2017, Pages

  Sheahan, Timothy P ^a   Sims, Amy C ^a   Graham, Rachel L ^a   Menachery, Vineet D ^a   Gralinski, Lisa E ^a   Case, James B ^b   Leist, Sarah R ^a   Pyrc, Krzysztof ^c   Feng, Joy Y ^d   Trantcheva, Iva ^d   Bannister, Roy ^d   Park, Yeojin ^d   Babusis, Darius ^d   Clarke, Michael O ^d   MacKman, Richard L ^d   Spahn, Jamie E ^d   Palmiotti, Christopher A ^d   Siegel, Dustin ^d   Ray, Adrian S ^d   Cihlar, Tomas ^d   Jordan, Robert ^d   Denison, Mark R ^e   Baric, Ralph S ^a   more..

^a IL   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c JAGIELLONIAN UNIVERSITY   (Poland)

^d GILEAD SCIENCES   (United States)

^e VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

REMDESIVIR; ALANINE; ANTIVIRUS AGENT; GS-5734; RIBONUCLEOTIDE;

AIRWAY EPITHELIUM CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIVIRAL ACTIVITY; ARTICLE; CELL CULTURE; CLINICAL FEATURE; CONTROLLED STUDY; CYTOTOXICITY TEST; DRUG HALF LIFE; DRUG POTENCY; FEMALE; HUMAN; HUMAN CELL; IC50; INFECTION PREVENTION; MALE; MIDDLE EAST RESPIRATORY SYNDROME; MOUSE; MOUSE MODEL; NONHUMAN; PRIORITY JOURNAL; RESPIRATORY FUNCTION; SEVERE ACUTE RESPIRATORY SYNDROME; VIRUS LOAD; VIRUS REPLICATION; ANALOGS AND DERIVATIVES; ANIMAL; CALLITHRIX; CELL LINE; CORONAVIRINAE; DRUG EFFECTS; EPIDEMIC; EPITHELIUM CELL; LUNG; METABOLISM; PATHOLOGY; VIROLOGY; ZOONOSIS;

ALANINE; ANIMALS; ANTIVIRAL AGENTS; CALLITHRIX; CELL LINE; CORONAVIRUS; EPIDEMICS; EPITHELIAL CELLS; HUMANS; LUNG; MICE; RIBONUCLEOTIDES; VIRUS REPLICATION; ZOONOSES;

EID: 85021671152     PISSN: 19466234     EISSN: 19466242     Source Type: Journal    
DOI: 10.1126/scitranslmed.aal3653     Document Type: Article

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