Is olive oil good for you? A systematic review and meta-analysis on anti-inflammatory benefits from regular dietary intake

Nutrition

Volumn 69, Issue , 2020, Pages

  Fernandes, João ^a   Fialho, Mónica ^a   Santos, Rodrigo ^a   Peixoto Plácido, Catarina ^a   Madeira, Teresa ^a   Sousa Santos, Nuno ^a,b   Virgolino, Ana ^a   Santos, Osvaldo ^a   Vaz Carneiro, António ^a  

^a INSTITUTO DE MEDICINA MOLECULAR   (Portugal)

^b POLYTECHNIC INSTITUTE OF LEIRIA   (Portugal)

Author keywords

C reactive protein; Inflammation; Interleukin 6; Mediterranean diet; Tumor necrosis factor

Indexed keywords

C REACTIVE PROTEIN; INTERLEUKIN 6; OLIVE OIL; TUMOR NECROSIS FACTOR; ANTIINFLAMMATORY AGENT; AUTACOID;

ANTIINFLAMMATORY ACTIVITY; DIETARY INTAKE; DRUG EFFECT; FAT INTAKE; FOLLOW UP; FOOD INTAKE; HUMAN; INFLAMMATION; META ANALYSIS; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; SYSTEMATIC REVIEW; TREATMENT DURATION; TREATMENT OUTCOME; BLOOD; EATING; MEDITERRANEAN DIET; PHYSIOLOGY; PROCEDURES;

ANTI-INFLAMMATORY AGENTS; C-REACTIVE PROTEIN; DIET, HEALTHY; DIET, MEDITERRANEAN; EATING; HUMANS; INFLAMMATION MEDIATORS; INTERLEUKIN-6; OLIVE OIL; RANDOMIZED CONTROLLED TRIALS AS TOPIC; TUMOR NECROSIS FACTOR-ALPHA;

EID: 85072244638     PISSN: 08999007     EISSN: 18731244     Source Type: Journal    
DOI: 10.1016/j.nut.2019.110559     Document Type: Review

References (67)

1. World Health Organization. Global action plan for the prevention and control of noncommunicable diseases 2013-2020. Geneva, Switzerland: Author; 2013. p. 102.
2. Forouzanfar M.H., Afshin A., Alexander L.T., Ross Anderson H., Bhutta Z.A., Biryukov S., et al. Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet2016;388:1659–724.
3. World Health Organization. Top 10 causes of death. Available at: https://www.who.int/news-room/fact-sheets/detail/the-top-10-causes-of-death. Accessed 9 August 2019.
4. Keys A., Menotti A., Karvonen M.J., Aravanis C., Blackburn H., Buzina R., et al. The diet and 15-year death rate in the seven countries study. Am J Epidemiol1986;124:903–15.
5. UNESCO. MEDDIET the Mediterranean diet. Available at: http://pt.dietamedunesco.it/. Accessed 6 August 2019.
6. Lacirignola C., Capone R.Mediterranean food consumption patterns and health: diet, environment, society, economy. A White Paper Priority 5 of Feeding Knowledge Programme, Expo Milan 2015. Rome: Bari/FAO, CIHEAM-IAMB; 2015.
7. Cicerale S., Lucas L., Keast R., Gazzani G., Grusak M.Antimicrobial, antioxidant and anti-inflammatory phenolic activities in extra virgin olive oil. Curr Opin Biotechnol2011;23:129–35.
8. Virruso C., Accardi G., Colonna-Romano G., Candore G., Vasto S., Caruso C.Nutraceutical properties of extra-virgin olive oil: a natural remedy for age-related disease?Rejuvenation Res2014;17:217–20.
9. Visioli F., Poli A., Gall C.Antioxidant and other biological activities of phenols from olives and olive oil. Med Res Rev2002;22:65–75.
10. Bulotta S., Celano M., Lepore S.M., Montalcini T., Pujia A., Russo D.Beneficial effects of the olive oil phenolic components oleuropein and hydroxytyrosol: focus on protection against cardiovascular and metabolic diseases. J Transl Med2014;12:1–9.
11. Martinez-Gonzalez M.A., Martin-Calvo N.Mediterranean diet and life expectancy; beyond olive oil, fruits, and vegetables. Curr Opin Clin Nutr Metab Care2016;19:401–7.
12. Ghanbari R., Anwar F., Alkharfy K.M., Gilani A.H., Saari N.Valuable nutrients and functional bioactives in different parts of olive (Olea europaea L.)—a review. Int J Mol Sci2012;13:3291–340.
13. Turck D, Bresson JL, Burlingame B, et al. Guidance for the scientific requirements for health claims related to antioxidants, oxidative damage and cardiovascular health: (Revision 1). EFSA J. 2018;16(1):1-21.
14. Rosignoli P., Fuccelli R., Fabiani R., Servili M., Morozzi G.Effect of olive oil phenols on the production of inflammatory mediators in freshly isolated human monocytes. J Nutr Biochem2013;24:1513–9.
15. Lucas L., Russell A., Keast R.Molecular mechanisms of inflammation. anti-inflammatory benefits of virgin olive oil and the phenolic compound oleocanthal. Curr Pharm Des2011;17:754–68.
16. Tutino V., Caruso M., Messa C., Perri E., Notarnicola M.Antiproliferative, antioxidant and anti-inflammatory effects of hydroxytyrosol on human hepatoma HepG2 and Hep3 B cell lines. Anticancer Res2012;32:5371–8.
17. Scoditti E., Calabriso N., Massaro M., Pellegrino M., Storelli C., Martines G., et al. Mediterranean diet polyphenols reduce inflammatory angiogenesis through MMP-9 and COX-2 inhibition in human vascular endothelial cells: s potentially protective mechanism in atherosclerotic vascular disease and cancer. Arch Biochem Biophys2012;527:81–9.
18. Camargo A., Rangel-Zuñiga A., Haro C., Meza-Miranda E.R., Peña-Orihuela P., Meneses M.E., et al. Olive oil phenolic compounds decrease the postprandial inflammatory response by reducing postprandial plasma lipopolysaccharide levels. Food Chem2014;162:161–71.
19. Luque-Sierra A., Alvarez-Amor L., Kleemann R., Martín F., Varela L.M.Extra-virgin olive oil with natural phenolic content exerts an anti-inflammatory effect in adipose tissue and attenuates the severity of atherosclerotic lesions in Ldlr−/−.Leiden mice. Mol Nutr Food Res2018;62:1800295.
20. Jain S., Buttar H.S., Chintameneni M., Kaur G.Prevention of cardiovascular diseases with anti-inflammatory and anti-oxidant nutraceuticals and herbal products: an overview of pre-clinical and clinical studies. Recent Pat Inflamm Allergy Drug Discov2018;12:145–57.
21. Baker R.G., Hayden M.S., Ghosh S.NF-κB, inflammation, and metabolic disease. Cell Metab2011;13:11–22.
22. Coussens L.M., Werb Z.Inflammation and cancer. Nature2002;420:860–7.
23. Roifman I., Beck P.L., Anderson T.J., Eisenberg M.J., Genest J.Chronic inflammatory diseases and cardiovascular risk: a systematic review. Can J Cardiol2011;27:174–82.
24. Inaba Y., Chen J.A., Bergmann S.R.Prediction of future cardiovascular outcomes by flow-mediated vasodilatation of brachial artery: a meta-analysis. Int J Cardiovasc Imaging2010;26:631–40.
25. Schwingshackl L., Hoffmann G.Monounsaturated fatty acids, olive oil and health status: a systematic review and meta-analysis of cohort studies. Lipids Health Dis2014;13:1–15.
26. Schwingshackl L., Christoph M., Hoffmann G.Effects of olive oil on markers of inflammation and endothelial function—a systematic review and meta-analysis. Nutrients2015;7:7651–75.
27. Reboredo-Rodríguez P., Varela-López A., Forbes-Hernández T.Y., Gasparrini M., Afrin S., Cianciosi D., et al. Phenolic compounds isolated from olive oil as nutraceutical tools for the prevention and management of cancer and cardiovascular diseases. Int J Mol Sci2018;19:2305.
28. Alkhatib A., Tsang C., Tuomilehto J.Olive oil nutraceuticals in the prevention and management of diabetes: from molecules to lifestyle. Int J Mol Sci2018;19:2024.
29. Schwingshackl L., Lampousi A.-M., Portillo M.P., Romaguera D., Hoffmann G., Boeing H.Olive oil in the prevention and management of type 2 diabetes mellitus: a systematic review and meta-analysis of cohort studies and intervention trials. Nutr Diabetes2017;7:e262.
30. Saibandith B., Spencer J.P.E., Rowland I.R., Commane D.M.Olive polyphenols and the metabolic syndrome. Molecules2017;22:1082.
31. Figueiredo-González M., Reboredo-Rodríguez P., González-Barreiro C., Simal-Gándara J., Valentão P., Carrasco-Pancorbo A., et al. Evaluation of the neuroprotective and antidiabetic potential of phenol-rich extracts from virgin olive oils by in vitro assays. Food Res Int2018;106:558–67.
32. Angeloni C., Malaguti M., Barbalace M., Hrelia S.Bioactivity of olive oil phenols in neuroprotection. Int J Mol Sci2017;18:2230.
33. Aparicio-Soto M., Sánchez-Hidalgo M., Rosillo M.Á., Castejón M.L., Alarcón-De-La-Lastra C.Extra virgin olive oil: a key functional food for prevention of immune-inflammatory diseases. Food Funct2016;7:4492–505.
34. Parkinson L., Cicerale S.The health benefiting mechanisms of virgin olive oil phenolic compounds. Molecules2016;21:1–12.
35. Gotsis E., Anagnostis P., Mariolis A., Vlachou A., Katsiki N., Karagiannis A.Health benefits of the mediterranean diet: an update of research over the last 5 years. Angiology2015;66:304–18.
36. Elbourne D.R., Altman D.G., Higgins J.P., Curtin F., Worthington H.V., Vail A.Meta-analyses involving cross-over trials: methodological issues. Int J Epidemiol2002;31:140–9.
37. Higgins J.P., Green S., eds. Cochrane handbook for systematic reviews of interventions. Chichester, UK: John Wiley & Sons; 2008.
38. Review Manager (RevMan) [computer program]. Version 5.3. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration; 2014.
39. Higgins J.P.T., White I.R., Anzures-Cabrera J.Meta-analysis of skewed data: combining results reported on log-transformed or raw scales. Stat Med2008;27:6072–92.
40. Higgins J.P.T., Thompson S.G., Deeks J.J., Altman D.G.Measuring inconsistency in meta-analyses. BMJ2003;327:557–60.
41. Camargo A., Delgado-Lista J., Garcia-Rios A., Cruz-Teno C., Yubero-Serrano E.M., Perez-Martinez P., et al. Expression of proinflammatory, proatherogenic genes is reduced by the Mediterranean diet in elderly people. Br J Nutr2012;108:500–8.
42. Casas R., Sacanella E., Urpí-Sardà M., Chiva-Blanch G., Ros E., Martínez-Gonzá lez M.-A., et al. The effects of the Mediterranean diet on biomarkers of vascular wall inflammation and plaque vulnerability in subjects with high risk for cardiovascular disease. A randomized trial. PLoS One2014;9:1–6.
43. Casas R., Sacanella E., Urp M., Corella D., Castan O., Salas-salvad J., et al. Long-term immunomodulatory effects of a mediterranean diet in adults at high risk of cardiovascular disease in the PREvencion con DIeta MEDiterranea randomized controlled trial. J Nutr2016:1–10.
44. Casas R., Urpi-Sardà M., Sacanella E., Arranz S., Corella D., Castañer O., et al. Anti-inflammatory effects of the Mediterranean Diet in the early and late stages of atheroma plaque development. Mediators Inflamm2017;2017:1–13.
45. Castañer O., Corella D., Covas M.-I., Sorlí J V., Subirana I., Flores-Mateo G., et al. In vivo transcriptomic profile after a Mediterranean diet in high–cardiovascular risk patients: a randomized ontrolled trial. Am J Clin Nutr2013;98:845–53.
46. Ceriello A., Esposito K., La Sala L., Pujadas G., De Nigris V., Testa R., et al. The protective effect of the Mediterranean diet on endothelial resistance to GLP-1 in type 2 diabetes: a preliminary report. Cardiovasc Diabetol2014;13:1–9.
47. Urpi-sarda M., Casas R., Chiva-blanch G., Sau E., Andres-lacueva C., Llorach R., et al. The Mediterranean diet pattern and its main components are associated with lower plasma concentrations of tumor necrosis factor receptor 60 in patients at high risk for cardiovascular disease 1 – 4. J Nutr Dis2012;142:1019–25.
48. Lee S.T., Voon P.T., Ng T.K.W., Esa N., Lee V.K.M., Saad H.A., et al. Effects of palm-based high-oleic blended cooking oil diet on selected biomarkers of inflammation and obesity compared to extra virgin olive oil diet in overweight Malaysian adults. J Oil Palm Res2018;30:289–98.
49. Voon P.T., Ng T.K.W., Lee V.K.M., Nesaretnam K.Diets high in palmitic acid (16:0), lauric and myristic acids (12:0 + 14:0), or oleic acid (18:1) do not alter postprandial or fasting plasma homocysteine and inflammatory markers in healthy Malaysian adults. Am J Clin Nutr2011;94:1451–7.
50. De Oliveira P.A., Kovacs C., Moreira P.Unsaturated fatty acids improve atherosclerosis markers in obese and overweight non-diabetic elderly patients. Obes Surg2017;27:2663–71.
51. Tholstrup T., Hjerpsted J., Raff M.Palm olein increases plasma cholesterol moderately compared with olive oil in healthy individuals 1 – 3. Am J Clin Nutr2011:1426–32.
52. Rezaei S., Akhlaghi M., Sasani M.R., Boldaji R.B.Olive oil improved fatty liver severity independent of cardiometabolic correction in patients with non-alcoholic fatty liver disease, a randomized clinical trial. Nutrition2019;57:154–61.
53. Khaw K.-T., Sharp S.J., Finikarides L., Afzal I., Lentjes M., Luben R., et al. Randomised trial of coconut oil, olive oil or butter on blood lipids and other cardiovascular risk factors in healthy men and women. BMJ Open2018;8:e020167.
54. Abdelhamid A.S., Brown T.J., Brainard J.S., Biswas P., Thorpe G.C., Moore H.J., et al. Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease. Cochrane Database Syst Rev2018;7:CD003177.
55. Estruch R., Ros E., Salas-Salvadó J., Covas M.-I., Corella D., Arós F., et al. Primary prevention of cardiovascular disease with a Mediterranean diet supplemented with extra-virgin olive oil or nuts. N Engl J Med2018;378:e34.
56. Rieckmann P., Tuscano J.M., Kehrl J.H.Tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in B-lymphocyte function. Methods1997;11:128–32.
57. Weaver C.M., Miller J.W.Challenges in conducting clinical nutrition research. Nutr Rev2017;75:491–9.
58. Curtin F.Meta-analysis combining parallel and cross-over trials with random effects. Res Synth Methods2017;8:263–74.
59. Curtin F., Altman D.G., Elbourne D.Meta-analysis combining parallel and cross-over clinical trials. I: continuous outcomes. Stat Med2002;21:2131–44.
60. Cicerale S., Lucas L., Keast R.Biological activities of phenolic compounds present in virgin olive oil. Int J Mol Sci2010;11:458–79.
61. Garcia-Martinez O., Ruiz C., Gutierrez-Ibanez A., Illescas-Montes R., Melguizo-Rodriguez L.Benefits of olive oil phenolic compounds in disease prevention. Endocrine Metab Immune Disord - Drug Targets2018;18:333–40.
62. Casas R., Sacanella E., Estruch R.The Immune Protective Effect of the Mediterranean Diet against Chronic Low-grade Inflammatory Diseases. Endocr Metab Immune Disord Drug Targets2014;14:245–54.
63. Bianchi V.E.Weight loss is a critical factor to reduce inflammation. Clin Nutr ESPEN2018;28:21–35.
64. Krishnan S., Cooper J.A.Effect of dietary fatty acid composition on substrate utilization and body weight maintenance in humans. Eur J Nutr2014;53:691–710.
65. Martínez-González M.A., Dominguez L.J., Delgado-Rodríguez M.Olive oil consumption and risk of CHD and/or stroke: a meta-analysis of case–control, cohort and intervention studies. Br J Nutr2014;112:248–59.
66. European Food Safety Authority. Scientific opinion on the substantiation of health claims related to polyphenols in olive and protection of LDL particles from oxidative damage (ID 1333, 1638, 1639, 1696, 2865), maintenance of normal blood HDL-cholesterol concentrations (ID 1639), mainte. EFSA J2011;9:1–25.
67. Sterne J.A.C., Sutton A.J., Ioannidis J.P.A., Terrin N., Jones D.R., Lau J., et al. Recommendations for examining and interpreting funnel plot asymmetry in meta-analyses of randomised controlled trials. BMJ2011;343:d4002–d4002.