Evaluation of the neuroprotective and antidiabetic potential of phenol-rich extracts from virgin olive oils by in vitro assays

Food Research International

Volumn 106, Issue , 2018, Pages 558-567

  Figueiredo Gonzalez M ^a,b   Reboredo Rodriguez P ^a,c   Gonzalez Barreiro C ^a   Simal Gandara J ^a   Valentao P ^b   Carrasco Pancorbo, A ^d   Andrade, P B ^b   Cancho Grande, B ^a  

^a UNIVERSITY OF VIGO   (Spain)

^b UNIVERSITY OF PORTO   (Portugal)

^c UNIVERSITÀ POLITECNICA DELLE MARCHE   (Italy)

^d UNIVERSITY OF GRANADA   (Spain)

Author keywords

Cornicabra cv.; Diabetes mellitus; Extra virgin olive oil; Neuroprotection; Phenols; Picual cv.

Indexed keywords

ENZYMES; NEURODEGENERATIVE DISEASES; PHENOLS;

CORNICABRA CV; DIABETES MELLITUS; EXTRA VIRGIN OLIVE OIL; NEUROPROTECTION; PICUAL CV;

OLIVE OIL;

ACETYLCHOLINESTERASE; ALPHA GLUCOSIDASE; AMINE OXIDASE (FLAVIN CONTAINING); AMYLASE; ANTIDEPRESSANT AGENT; ANTIOXIDANT; ANTIPARKINSON AGENT; ARACHIDONATE 5 LIPOXYGENASE; CHOLINESTERASE; CHOLINESTERASE INHIBITOR; GLYCOSIDASE INHIBITOR; LIPOXYGENASE INHIBITOR; MONOAMINE OXIDASE A, HUMAN; MONOAMINE OXIDASE INHIBITOR; NEUROPROTECTIVE AGENT; OLIVE OIL; PHENOL DERIVATIVE;

CHEMISTRY; CLASSIFICATION; COMPARATIVE STUDY; DOSE RESPONSE; ISOLATION AND PURIFICATION; METABOLISM;

ACETYLCHOLINESTERASE; ALPHA-AMYLASES; ALPHA-GLUCOSIDASES; ANTIDEPRESSIVE AGENTS; ANTIOXIDANTS; ANTIPARKINSON AGENTS; ARACHIDONATE 5-LIPOXYGENASE; BUTYRYLCHOLINESTERASE; CHOLINESTERASE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; GLYCOSIDE HYDROLASE INHIBITORS; LIPOXYGENASE INHIBITORS; MONOAMINE OXIDASE; MONOAMINE OXIDASE INHIBITORS; NEUROPROTECTIVE AGENTS; OLIVE OIL; PHENOLS;

EID: 85041442733     PISSN: 09639969     EISSN: 18737145     Source Type: Journal    
DOI: 10.1016/j.foodres.2018.01.026     Document Type: Article

References (45)

1. Bajoub, A., Fernández-Gutierrez, A., Carrasco-Pancorbo, A., Evaluating the potential of phenolic profiles as discriminant features among extra virgin olives oils form Moroccan controlled designations of origin. Food Research International 84 (2016), 41–51.
2. Bajoub, A., Medina-Rodríguez, S., Olmo-García, L., Ajal, E.A., Monasterio, R., Hanine, H., Carrasco-Pancorbo, A., In-depth two-year study of phenolic profile variability among olive oils from autochthonous and Mediterranean varieties in Morocci, as revealed by a LC-MS chemometric profiling approach. International Journal of Molecular Sciences 18 (2017), 52–74.
3. Bandaruk, Y., Mukai, R., Kawamura, T., Nemoto, H., Terao, J., Evaluation of the inhibitory effects of quercetin-related flavonoids and tea catechins on the monoamine oxidase reaction in mouse brain mitochondria. Journal of Agricultural and Food Chemistry 60 (2012), 10270–10277.
4. Bekir, J., Mars, M., Souchard, J.P., Bouajila, J., Assessment of antioxidant, anti-inflammatory, anti-cholinesterase and cytotoxic activities of pomegranate (Punica granatum) leaves. Food and Chemical Toxicology 55 (2013), 470–475.
5. Bendini, A., Cerretani, L., Carrasco-Pancorbo, A., Gómez-Caravaca, A.M., Segura-Carretero, A., Fernández-Gutiérrez, A., Lercker, G., Phenolic molecules in virgin olive oils: A survey of their sensory properties, health effects, antioxidant activity and analytical methods. An overview of the last decade. Molecules 12 (2007), 1679–1719.
6. Bernardo, J., Ferreres, F., Gil-Izquierdo, A., Valentão, P., Andrade, P.B., Medicinal species as MTDLs: Turnera diffusa Willd. Ex Schult inhibits CNS-enzymes and delays glutamate excitotoxicity in SH-SY5Y cells via oxidative damage. Food and Chemical Toxicology 106 (2017), 466–476.
7. Brenes, M., Hidalgo, F.J., García, A., Rios, J.J., García, P., Zamora, R., Garrido, A., Pinoresinol and 1-acetoxypinoresinol, two new phenolic compounds identified in olive oil. Journal of the American Oil Chemists’ Society 77 (2000), 715–720.
8. Bulotta, S., Celano, M., Lepore, S.M., Montalcini, T., Pujia, A., Russo, D., Beneficial effects of the olive oil phenolic components oleuropein and hydroxytyrosol: Focus on protection against cardiovascular and metabolic diseases. Journal of Translational Medicine 12 (2014), 219–241.
9. Casas, R., Sacanella, E., Urpí-Sardà M., Chiva-Blanch, G., Ros, E., Martínez-González, M.A., Estruch, R., The effects of the Mediterranean diet on biomarkers of vascular wall inflammation and plaque vulnerability in subjects with high risk for cardiovascular disease. A randomized trial. PLoS One, 9, 2014, e100084.
10. Chaurasiya, N.D., Ibrahim, M.A., Muhammad, I., Walker, L.A., Tekwani, B.L., Monoamine oxidase inhibitory constituents of Propolis: Kinetics and mechanism of inhibition of recombinant human MAO-A and MAO-B. Molecules 19 (2014), 18936–18952.
11. Collado-González, J., Grosso, C., Valentão, P., Andrade, P.B., Ferreres, F., Durand, T., Gil-Izquierdo, Á., Inhibition of α-glucosidase and α-amylase by Spanish extra virgin olive oils: The involvement of bioactive compounds other than oleuropein and hydroxytyrosol. Food Chemistry 235 (2017), 298–307.
12. Commission Regulation, (EU) No 432/2012 of 16 May 2012 establishing a list of permitted health claims made on foods, other than those referring to the reduction of disease risk and to children's development and health. 2012.
13. Conforti, F., Rigano, D., Formisano, C., Bruno, M., Loizzo, M.R., Menichini, F., Senatore, F., Metabolite profile and in vitro activities of Phagnalon saxatile (L.) Cass. relevant to treatment of Alzheimer's disease. Journal of Enzyme Inhibition and Medicinal Chemistry 25 (2010), 97–104.
14. Czapski, G.A., Czubowicz, K., Strosznajder, J.B., Strosznajder, R.P., The lipoxygenases: Their regulation and implication in Alzheimer's disease. Neurochemical Research 41 (2016), 243–257.
15. Dzoyem, J.P., Eloff, J.N., Anti-inflammatory, anticholinesterase and antioxidant activity of leaf extracts of twelve plants used traditionally to alleviate pain and inflammation in South Africa. Journal of Ethnopharmacology 160 (2015), 194–201.
16. El-Hassan, A., El-Sayed, M., Hamed, A.I., Rhee, I.K., Ahmen, A.A., Zeller, K.P., Verpoorte, R., Bioactive constituents of Leptadenia arborea. Fitoterapia 74 (2003), 184–187.
17. Etxeberria, U., de la Garza, A.L., Campion, J., Martinez, J.A., Milagro, F.I., Antidiabetic effects of natural plant extracts via inhibition of carbohydrate hydrolysis enzymes with emphasis on pancreatic alpha amylase. Expert Opinion on Therapeutic Targets 16 (2012), 269–297.
18. Figueiredo-González, M., Grosso, C., Valentão, P., Andrade, P.B., α-Glucosidase and α-amylase inhibitors from Myrcia spp.: A stronger alternative to acarbose?. Journal of Pharmaceutical and Biomedical Analysis 118 (2016), 322–327.
19. Finberg, J.P.M., Rabey, J.M., Inhibitors of MAO-A and MAO-B in psychiatry and neurology. Frontiers in Pharmacology, 7(340), 2016.
20. Giacobini, E., Cholinesterases: New roles in brain function and in Alzheimer's disease. Neurochemical Research 28 (2004), 515–522.
21. Gorinstein, S., Martín-Belloso, O., Katrich, E., Lojek, A., Cíz, M., Gligelmo-Miguel, N., Trakhtenberg, S., Comparison of the contents of the main biochemical compounds and the antioxidant activity of some Spanish olive oils as determind by four different radical scavening tests. Journal of Nutritional Biochemistry 14 (2003), 154–159.
22. Hadrich, F., Bouallagui, Z., Junkyu, H., Isoda, H., Sayadi, S., The α-glucosidase and α- amylase enzyme inhibitory of hydroxytyrosol and oleuropein. Journal of Oleo Science 64 (2015), 835–843.
23. Hervert-Hernández, D., García, O.P., Rosado, J.L., Goñi, I., The contribution of fruits and vegetables to dietary intake of polyphenols and antioxidant capacity in a Mexican rural diet: Importance of fruit and vegetable variety. Food Research International 44 (2011), 1182–1189.
24. Jung, H.A., Roy, A., Choi, J.S., In vitro monoamine oxidase A and B inhibitory activity and molecular docking simulations of fucoxanthin. Fisheries Science 83 (2017), 123–132.
25. Kulshreshtha, A., Piplani, P., Current pharmacotherapy and putative disease-modifying therapy for Alzheimer's disease. Neurological Sciences 37 (2016), 1403–1435.
26. Laddomada, B., Colella, G., Tufariello, M., Durante, M., Angiuli, M., Salvetti, G., Mita, G., Application of a simplified calorimetric assay for the evaluation of extra virgin olive oil quality. Food Research International 54 (2013), 2062–2068.
27. Lee, E.J., Kim, J.S., Kim, H.P., Lee, J.H., Kang, S.S., Phenolic constituents from the flower buds of Lonicera japonica and their 5-lipoxygenase inhibitory activities. Food Chemistry 120 (2010), 134–139.
28. Leyen, V.K., Arai, K., Jin, G., Kenyon, V., Gerstner, B., Rosenberg, P.A., Lo, E.H., Novel lipoxygenase inhibitors as neuroprotective reagents. Journal of Neuroscience Research 86 (2008), 904–909.
29. Loizzo, M.R., Di Lecce, G., Boselli, E., Menichini, F., Frega, N.G., Inhibitory activity of phenolic compounds from extra virgin olive oils on the enzymes involved in diabetes, obesity and hypertension. Journal of Food Biochemistry 35 (2011), 381–399.
30. Mayneris-Perxachs, J., Sala-Vila, A., Chisaguano, M., Castellote, A.I., Estruch, R., Covas, M.I., López-Sabater, M.C., Effects of 1-year intervention with a Mediterranean diet on plasma fatty acid composition and metabolic syndrome in a population at high cardiovascular risk. PLoS One, 9, 2014, e85202.
31. Menichini, F., Tundis, R., Bonesi, M., Loizzo, M.R., Conforti, F., Statti, G., Menichini, F., The influence of fruit ripening on the phytochemical content and biological activity of Capsicum chinense Jacq. cv. Habanero. Food Chemistry 114 (2009), 553–560.
32. Olesen, J., Gustavsson, A., Svensson, M., Wittchen, H.U., Jӧnsson, B. et al., The economic cost of brain disorders in Europe. European Journal of Neurology 19 (2012), 155–162.
33. Parkinson, L., Keast, R., Oleocanthal, a phenolic derived from virgin olive oil: A review of the beneficial effects on inflammatory disease. International Journal of Molecular Sciences 5 (2014), 12323–12334.
34. Pereira, R.B., Taveira, M., Valentão, P., Sousa, C., Andrade, P.B., Fatty acids from edible sea hares: Anti-inflammatory capacity in LPS-stimulated RAW 264.7 cells involves iNOS modulation. RSC Advances 5 (2015), 8981–8987.
35. Reboredo-Rodríguez, P., Figueiredo-González, M., González-Barreiro, C., Simal-Gándara, J., Salvador, M.D., Cancho-Grande, B., Fregapane, G., State-of-the-art on functional virgin olive oils enriched with bioactive compounds and their properties. International Journal of Molecular Sciences, 18, 2017 668–195.
36. Reboredo-Rodríguez, P., Rey-Salgueiro, L., Regueiro, J., González-Barreiro, C., Cancho-Grande, B., Simal-Gándara, J., Ultrasound-assisted emulsification–microextraction for the determination of phenolic compounds in olive oils. Food Chemistry 150 (2014), 128–136.
37. Reboredo-Rodríguez, P., Valli, E., Bendini, A., Di Lecce, G., Simal-Gandara, J., Gallina Toschi, T., A widely used spectrophotometric assay to quantify olive oil biophenols according to the health claim (EU Reg. 432/2012). European Journal of Lipid Science and Technology 118 (2016), 1593–1599.
38. Samaniego Sánchez, C., Troncoso González, A.M., García-Parrilla, M.C., Quesada Granados, J.J., López García de la Serrana, H., López Martínez, M.C., Different radical scavenging tests in virgin olive oil and their relation to the total phenol content. Analytica Chimica Acta 593 (2007), 103–107.
39. Szwajgier, D., Borowiec, K., Phenolic acids from malt are efficient acetylcholinesterase and butyrylcholinesterase inhibitors. Journal of the Institute of Brewing 118 (2012), 40–48.
40. Tadera, K., Minami, Y., Takamatsu, K., Matsuoka, T., Inhibition of α-glucosidase and α-amylase by flavonoids. Journal of Nutritional Science and Vitaminology 52 (2006), 149–153.
41. Tang, H.Y., Bai, M.M., Tian, J.M., Pescitelli, G., Ivšić T., Huang, X.H., Gao, J.M., Chemical components from the seeds of Catalpa bungei and their inhibitions of soluble epoxide hydrolase, cholinesterase and nuclear factor kappa B activities. RSC Advances 6 (2016), 40706–40716.
42. Taveira, M., Sousa, C., Valentão, P., Ferreres, F., Teixeira, J.P., Andrade, P.B., Neuroprotective effect of steroidal alkaloids on glutamate-induced toxicity by preserving mitochondrial membrane potential and reducing oxidative stress. Journal of Steroid Biochemistry and Molecular Biology 140 (2014), 106–115.
43. Tovar, M.J., Romero, M.P., Alegre, S., Girona, J., Motilva, M.J., Composition and organoleptic characteristics of oil from Arbequina olive (Olea europea L) trees under deficit irrigation. Journal of the Science of Food and Agriculture 82 (2002), 1755–1763.
44. Vinholes, J., Grosso, C., Andrade, P.B., Gil-Izquierdo, A., Valentão, P., de Pinho, P.G., Ferreres, F., In vitro studies to assess the antidiabetic, anti-cholinesterase and antioxidant potential of Spergularia rubra. Food Chemistry 129 (2011), 454–462.
45. Voss, C., Sepulveda-Boza, S., Zilliken, F.W., New isoflavonoids as inhibitors of porcine 5-lipoxygenase. Biochemical Pharmacology 44 (1992), 157–162.