메뉴 건너뛰기




Volumn 13, Issue , 2019, Pages 57-70

Tocilizumab in the treatment of rheumatoid arthritis: An evidence-based review and patient selection

Author keywords

Clinical trials; Efficacy; IL 6; Profiling; Real life

Indexed keywords

ABATACEPT; ADALIMUMAB; ETANERCEPT; INFLIXIMAB; INTERLEUKIN 6; LIPID; METHOTREXATE; PLACEBO; RITUXIMAB; TOCILIZUMAB; TOFACITINIB; ANTIRHEUMATIC AGENT; IL6R PROTEIN, HUMAN; INTERLEUKIN 6 RECEPTOR; MONOCLONAL ANTIBODY;

EID: 85059242042     PISSN: None     EISSN: 11778881     Source Type: Journal    
DOI: 10.2147/DDDT.S150580     Document Type: Review
Times cited : (111)

References (138)
  • 1
    • 84855172814 scopus 로고    scopus 로고
    • The pathogenesis of rheumatoid arthritis
    • McInnes IB, Schett G. The pathogenesis of rheumatoid arthritis. N Engl J Med Overseas Ed. 2011;365(23):2205–2219.
    • (2011) N Engl J Med Overseas Ed , vol.365 , Issue.23 , pp. 2205-2219
    • McInnes, I.B.1    Schett, G.2
  • 2
    • 84964773927 scopus 로고    scopus 로고
    • Rheumatoid arthritis
    • Smolen JS, Aletaha D, McInnes IB. Rheumatoid arthritis. Lancet. 2016;388(10055):2023–2038.
    • (2016) Lancet , vol.388 , Issue.10055 , pp. 2023-2038
    • Smolen, J.S.1    Aletaha, D.2    McInnes, I.B.3
  • 3
    • 84930607509 scopus 로고    scopus 로고
    • Treating rheumatoid arthritis to target: 2014 update of the recommendations of an international task force
    • Smolen JS, Breedveld FC, Burmester GR, et al. Treating rheumatoid arthritis to target: 2014 update of the recommendations of an international task force. Ann Rheum Dis. 2016;75(1):3–15.
    • (2016) Ann Rheum Dis , vol.75 , Issue.1 , pp. 3-15
    • Smolen, J.S.1    Breedveld, F.C.2    Burmester, G.R.3
  • 4
    • 84859438199 scopus 로고    scopus 로고
    • The pathogenesis of rheumatoid arthritis: New insights from old clinical data?
    • Smolen JS, Aletaha D, Redlich K. The pathogenesis of rheumatoid arthritis: new insights from old clinical data? Nat Rev Rheumatol. 2012; 8(4):235–243.
    • (2012) Nat Rev Rheumatol , vol.8 , Issue.4 , pp. 235-243
    • Smolen, J.S.1    Aletaha, D.2    Redlich, K.3
  • 5
    • 84954197348 scopus 로고    scopus 로고
    • Cytokines in rheumatoid arthritis – shaping the immunological landscape
    • McInnes IB, Buckley CD, Isaacs JD. Cytokines in rheumatoid arthritis – shaping the immunological landscape. Nat Rev Rheumatol. 2016;12(1):63–68.
    • (2016) Nat Rev Rheumatol , vol.12 , Issue.1 , pp. 63-68
    • McInnes, I.B.1    Buckley, C.D.2    Isaacs, J.D.3
  • 6
    • 85019702082 scopus 로고    scopus 로고
    • EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2016 update
    • Smolen JS, Landewé R, Bijlsma J, et al. EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2016 update. Ann Rheum Dis. 2017;76(6):960–977.
    • (2017) Ann Rheum Dis , vol.76 , Issue.6 , pp. 960-977
    • Smolen, J.S.1    Landewé, R.2    Bijlsma, J.3
  • 7
    • 84956767541 scopus 로고    scopus 로고
    • American College of Rheumatology guideline for the treatment of rheumatoid arthritis
    • Singh JA, Saag KG, Bridges SL, et al. American College of Rheumatology guideline for the treatment of rheumatoid arthritis. Arthritis Rheumatol. 2016;68(1):1–26.
    • (2016) Arthritis Rheumatol , vol.68 , Issue.1 , pp. 1-26
    • Singh, J.A.1    Saag, K.G.2    Bridges, S.L.3
  • 8
    • 85019208873 scopus 로고    scopus 로고
    • Efficacy of biological disease-modifying antirheumatic drugs: A systematic literature review informing the 2016 update of the EULAR recommendations for the management of rheumatoid arthritis
    • Nam JL, Takase-Minegishi K, Ramiro S, et al. Efficacy of biological disease-modifying antirheumatic drugs: a systematic literature review informing the 2016 update of the EULAR recommendations for the management of rheumatoid arthritis. Ann Rheum Dis. 2017; 76(6):1113–1136.
    • (2017) Ann Rheum Dis , vol.76 , Issue.6 , pp. 1113-1136
    • Nam, J.L.1    Takase-Minegishi, K.2    Ramiro, S.3
  • 9
    • 70049109275 scopus 로고    scopus 로고
    • TNF-α antagonist survival rate in a cohort of rheumatoid arthritis patients observed under conditions of standard clinical practice
    • Marchesoni A, Zaccara E, Gorla R, et al. TNF-α antagonist survival rate in a cohort of rheumatoid arthritis patients observed under conditions of standard clinical practice. Ann N Y Acad Sci. 2009;1173(1):837–846.
    • (2009) Ann N Y Acad Sci , vol.1173 , Issue.1 , pp. 837-846
    • Marchesoni, A.1    Zaccara, E.2    Gorla, R.3
  • 10
    • 84961880621 scopus 로고    scopus 로고
    • Twelve-year retention rate of first-line tumor necrosis factor inhibitors in rheumatoid arthritis: Real-life data from a local registry
    • Favalli EG, Pregnolato F, Biggioggero M, et al. Twelve-year retention rate of first-line tumor necrosis factor inhibitors in rheumatoid arthritis: real-life data from a local registry. Arthritis Care Res. 2016;68(4): 432–439.
    • (2016) Arthritis Care Res , vol.68 , Issue.4 , pp. 432-439
    • Favalli, E.G.1    Pregnolato, F.2    Biggioggero, M.3
  • 11
    • 85031754826 scopus 로고    scopus 로고
    • The management of first-line biologic therapy failures in rheumatoid arthritis: Current practice and future perspectives
    • Favalli EG, Raimondo MG, Becciolini A, Crotti C, Biggioggero M, Caporali R. The management of first-line biologic therapy failures in rheumatoid arthritis: current practice and future perspectives. Autoimmun Rev. 2017;16(12):1185–1195.
    • (2017) Autoimmun Rev , vol.16 , Issue.12 , pp. 1185-1195
    • Favalli, E.G.1    Raimondo, M.G.2    Becciolini, A.3    Crotti, C.4    Biggioggero, M.5    Caporali, R.6
  • 12
    • 84863861008 scopus 로고    scopus 로고
    • Understanding the dynamics: Pathways involved in the pathogenesis of rheumatoid arthritis
    • Choy E. Understanding the dynamics: pathways involved in the pathogenesis of rheumatoid arthritis. Rheumatology. 2012;51(Suppl 5): v3–v11.
    • (2012) Rheumatology , vol.51 , pp. v3-v11
    • Choy, E.1
  • 13
    • 77955096184 scopus 로고    scopus 로고
    • Therapeutic targets in rheumatoid arthritis: The interleukin-6 receptor
    • Dayer J-M, Choy E. Therapeutic targets in rheumatoid arthritis: the interleukin-6 receptor. Rheumatology. 2010;49(1):15–24.
    • (2010) Rheumatology , vol.49 , Issue.1 , pp. 15-24
    • Dayer, J.-M.1    Choy, E.2
  • 15
    • 85021014942 scopus 로고    scopus 로고
    • The role of IL-6 in host defence against infections: Immunobiology and clinical implications
    • Rose-John S, Winthrop K, Calabrese L. The role of IL-6 in host defence against infections: immunobiology and clinical implications. Nat Rev Rheumatol. 2017;13(7):399–409.
    • (2017) Nat Rev Rheumatol , vol.13 , Issue.7 , pp. 399-409
    • Rose-John, S.1    Winthrop, K.2    Calabrese, L.3
  • 16
    • 85028203484 scopus 로고    scopus 로고
    • Interleukin-6 and its receptors: A highly regulated and dynamic system
    • Wolf J, Rose-John S, Garbers C. Interleukin-6 and its receptors: a highly regulated and dynamic system. Cytokine. 2014;70(1):11–20.
    • (2014) Cytokine , vol.70 , Issue.1 , pp. 11-20
    • Wolf, J.1    Rose-John, S.2    Garbers, C.3
  • 17
    • 85044065443 scopus 로고    scopus 로고
    • Targeting the IL-6/JAK/ STAT3 signalling axis in cancer
    • Johnson DE, O’Keefe RA, Grandis JR. Targeting the IL-6/JAK/ STAT3 signalling axis in cancer. Nat Rev Clin Oncol. 2018;15(4): 234–248.
    • (2018) Nat Rev Clin Oncol , vol.15 , Issue.4 , pp. 234-248
    • Johnson, D.E.1    O’Keefe, R.A.2    Grandis, J.R.3
  • 19
    • 85041950348 scopus 로고    scopus 로고
    • How advances in personalized medicine will change rheumatology
    • Selmi C, Kon E, Santis MD, et al. How advances in personalized medicine will change rheumatology. Per Med. 2018;15(2):75–78.
    • (2018) Per Med , vol.15 , Issue.2 , pp. 75-78
    • Selmi, C.1    Kon, E.2    Santis, M.D.3
  • 20
    • 84965036066 scopus 로고    scopus 로고
    • Biologic efficacy optimization – a step towards personalized medicine
    • Kiely PDW. Biologic efficacy optimization – a step towards personalized medicine. Rheumatology. 2016;55(5):780–788.
    • (2016) Rheumatology , vol.55 , Issue.5 , pp. 780-788
    • Kiely, P.D.W.1
  • 21
    • 84961613409 scopus 로고    scopus 로고
    • Tailored first-line biologic therapy in patients with rheumatoid arthritis, spondyloarthritis, and psoriatic arthritis
    • Cantini F, Niccoli L, Nannini C, et al. Tailored first-line biologic therapy in patients with rheumatoid arthritis, spondyloarthritis, and psoriatic arthritis. Semin Arthritis Rheum. 2016;45(5):519–532.
    • (2016) Semin Arthritis Rheum , vol.45 , Issue.5 , pp. 519-532
    • Cantini, F.1    Niccoli, L.2    Nannini, C.3
  • 22
    • 85017457055 scopus 로고    scopus 로고
    • Second-line biologic therapy optimization in rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis
    • Cantini F, Niccoli L, Nannini C, et al. Second-line biologic therapy optimization in rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis. Semin Arthritis Rheum. 2017;47(2):183–192.
    • (2017) Semin Arthritis Rheum , vol.47 , Issue.2 , pp. 183-192
    • Cantini, F.1    Niccoli, L.2    Nannini, C.3
  • 23
    • 67349104400 scopus 로고    scopus 로고
    • Interleukin-6 as a key player in systemic inflammation and joint destruction
    • Fonseca JE, Santos MJ, Canhão H, Choy E. Interleukin-6 as a key player in systemic inflammation and joint destruction. Autoimmun Rev. 2009;8(7):538–542.
    • (2009) Autoimmun Rev , vol.8 , Issue.7 , pp. 538-542
    • Fonseca, J.E.1    Santos, M.J.2    Canhão, H.3    Choy, E.4
  • 24
    • 84944391205 scopus 로고    scopus 로고
    • Fatigue in rheumatoid arthritis: Quantitative findings on the efficacy of tocilizumab and on factors associated with fatigue. The French multicentre prospective PEPS Study
    • Gossec L, Steinberg G, Rouanet S, Combe B. Fatigue in rheumatoid arthritis: quantitative findings on the efficacy of tocilizumab and on factors associated with fatigue. The French multicentre prospective PEPS Study. Clin Exp Rheumatol. 2015;33(5):664–670.
    • (2015) Clin Exp Rheumatol , vol.33 , Issue.5 , pp. 664-670
    • Gossec, L.1    Steinberg, G.2    Rouanet, S.3    Combe, B.4
  • 25
    • 78149324897 scopus 로고    scopus 로고
    • Down-regulation of hepcidin resulting from long-term treatment with an anti-IL-6 receptor antibody (Tocilizumab) improves anemia of inflammation in multicentric Castleman disease
    • Song S-NJ, Tomosugi N, Kawabata H, Ishikawa T, Nishikawa T, Yoshizaki K. Down-regulation of hepcidin resulting from long-term treatment with an anti-IL-6 receptor antibody (tocilizumab) improves anemia of inflammation in multicentric Castleman disease. Blood. 2010;116(18):3627–3634.
    • (2010) Blood , vol.116 , Issue.18 , pp. 3627-3634
    • Song, S.-N.1    Tomosugi, N.2    Kawabata, H.3    Ishikawa, T.4    Nishikawa, T.5    Yoshizaki, K.6
  • 26
    • 84878134773 scopus 로고    scopus 로고
    • Relation of interleukin-6 in rheumatoid arthritis patients to systemic bone loss and structural bone damage
    • Abdel Meguid MH, Hamad YH, Swilam RS, Barakat MS. Relation of interleukin-6 in rheumatoid arthritis patients to systemic bone loss and structural bone damage. Rheumatol Int. 2013;33(3):697–703.
    • (2013) Rheumatol Int , vol.33 , Issue.3 , pp. 697-703
    • Abdel Meguid, M.H.1    Hamad, Y.H.2    Swilam, R.S.3    Barakat, M.S.4
  • 27
    • 85050267008 scopus 로고    scopus 로고
    • Neuroendocrine and neurophysiological effects of interleukin 6 in rheumatoid arthritis
    • Choy EHS, Calabrese LH. Neuroendocrine and neurophysiological effects of interleukin 6 in rheumatoid arthritis. Rheumatology. 2018; 57(11):1885–1895.
    • (2018) Rheumatology , vol.57 , Issue.11 , pp. 1885-1895
    • Choy, E.H.S.1    Calabrese, L.H.2
  • 28
    • 68549130286 scopus 로고    scopus 로고
    • The role of interleukins in insulin resistance and type 2 diabetes mellitus
    • Fève B, Bastard J-P. The role of interleukins in insulin resistance and type 2 diabetes mellitus. Nat Rev Endocrinol. 2009;5(6):305–311.
    • (2009) Nat Rev Endocrinol , vol.5 , Issue.6 , pp. 305-311
    • Fève, B.1    Bastard, J.-P.2
  • 29
    • 43249118045 scopus 로고    scopus 로고
    • Long-term interleukin-6 levels and subsequent risk of coronary heart disease: Two new prospective studies and a systematic review
    • Danesh J, Kaptoge S, Mann AG, et al. Long-term interleukin-6 levels and subsequent risk of coronary heart disease: two new prospective studies and a systematic review. PLoS Med. 2008;5(4):e78.
    • (2008) Plos Med , vol.5 , Issue.4 , pp. e78
    • Danesh, J.1    Kaptoge, S.2    Mann, A.G.3
  • 30
    • 0034681920 scopus 로고    scopus 로고
    • Plasma concentration of interleukin-6 and the risk of future myocardial infarction among apparently healthy men
    • Ridker PM, Rifai N, Stampfer MJ, Hennekens CH. Plasma concentration of interleukin-6 and the risk of future myocardial infarction among apparently healthy men. Circulation. 2000;101(15):1767–1772.
    • (2000) Circulation , vol.101 , Issue.15 , pp. 1767-1772
    • Ridker, P.M.1    Rifai, N.2    Stampfer, M.J.3    Hennekens, C.H.4
  • 31
    • 84877275257 scopus 로고    scopus 로고
    • Tocilizumab monotherapy versus adalimumab monotherapy for treatment of rheumatoid arthritis (ADACTA): A randomised, double-blind, controlled phase 4 trial
    • Gabay C, Emery P, van Vollenhoven R, et al. Tocilizumab monotherapy versus adalimumab monotherapy for treatment of rheumatoid arthritis (ADACTA): a randomised, double-blind, controlled phase 4 trial. Lancet. 2013;381(9877):1541–1550.
    • (2013) Lancet , vol.381 , Issue.9877 , pp. 1541-1550
    • Gabay, C.1    Emery, P.2    van Vollenhoven, R.3
  • 32
    • 85019144284 scopus 로고    scopus 로고
    • Efficacy and safety of sarilumab monotherapy versus adalimumab monotherapy for the treatment of patients with active rheumatoid arthritis (MONARCH): A randomised, double-blind, parallel-group phase III trial
    • Burmester GR, Lin Y, Patel R, et al. Efficacy and safety of sarilumab monotherapy versus adalimumab monotherapy for the treatment of patients with active rheumatoid arthritis (MONARCH): a randomised, double-blind, parallel-group phase III trial. Ann Rheum Dis. 2017; 76(5):840–847.
    • (2017) Ann Rheum Dis , vol.76 , Issue.5 , pp. 840-847
    • Burmester, G.R.1    Lin, Y.2    Patel, R.3
  • 33
    • 23944483417 scopus 로고    scopus 로고
    • IL-6: From laboratory to bedside
    • Kishimoto T. IL-6: from laboratory to bedside. Clin Rev Allergy Immunol. 2005;28(3):177–186.
    • (2005) Clin Rev Allergy Immunol , vol.28 , Issue.3 , pp. 177-186
    • Kishimoto, T.1
  • 34
    • 84904617950 scopus 로고    scopus 로고
    • The biology and medical implications of interleukin-6
    • Tanaka T, Kishimoto T. The biology and medical implications of interleukin-6. Cancer Immunol Res. 2014;2(4):288–294.
    • (2014) Cancer Immunol Res , vol.2 , Issue.4 , pp. 288-294
    • Tanaka, T.1    Kishimoto, T.2
  • 35
    • 0023851809 scopus 로고
    • The essential role of B cell stimulatory factor 2 (BSF-2/IL-6) for the terminal differentiation of B cells
    • Muraguchi A, Hirano T, Tang B, et al. The essential role of B cell stimulatory factor 2 (BSF-2/IL-6) for the terminal differentiation of B cells. J Exp Med. 1988;167(2):332–344.
    • (1988) J Exp Med , vol.167 , Issue.2 , pp. 332-344
    • Muraguchi, A.1    Hirano, T.2    Tang, B.3
  • 36
    • 0035869281 scopus 로고    scopus 로고
    • Interleukin-6 is a growth factor for nonmalignant human plasmablasts
    • Jego G, Bataille R, Pellat-Deceunynck C. Interleukin-6 is a growth factor for nonmalignant human plasmablasts. Blood. 2001;97(6): 1817–1822.
    • (2001) Blood , vol.97 , Issue.6 , pp. 1817-1822
    • Jego, G.1    Bataille, R.2    Pellat-Deceunynck, C.3
  • 37
    • 77954096689 scopus 로고    scopus 로고
    • IL-6: Regulator of Treg/Th17 balance
    • Kimura A, Kishimoto T. IL-6: regulator of Treg/Th17 balance. Eur J Immunol. 2010;40(7):1830–1835.
    • (2010) Eur J Immunol , vol.40 , Issue.7 , pp. 1830-1835
    • Kimura, A.1    Kishimoto, T.2
  • 38
    • 33646577466 scopus 로고    scopus 로고
    • Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
    • Bettelli E, Carrier Y, Gao W, et al. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature. 2006;441(7090):235–238.
    • (2006) Nature , vol.441 , Issue.7090 , pp. 235-238
    • Bettelli, E.1    Carrier, Y.2    Gao, W.3
  • 39
    • 32244442562 scopus 로고    scopus 로고
    • TGFβ in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T Cells
    • Veldhoen M, Hocking RJ, Atkins CJ, Locksley RM, Stockinger B. TGFβ in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T Cells. Immunity. 2006;24(2): 179–189.
    • (2006) Immunity , vol.24 , Issue.2 , pp. 179-189
    • Veldhoen, M.1    Hocking, R.J.2    Atkins, C.J.3    Locksley, R.M.4    Stockinger, B.5
  • 40
    • 0025228036 scopus 로고
    • Acute-phase response of human hepatocytes: Regulation of acute-phase protein synthesis by interleukin-6
    • Castell JV, Gómez-Lechón MJ, David M, Fabra R, Trullenque R, Heinrich PC. Acute-phase response of human hepatocytes: regulation of acute-phase protein synthesis by interleukin-6. Hepatology. 1990; 12(5):1179–1186.
    • (1990) Hepatology , vol.12 , Issue.5 , pp. 1179-1186
    • Castell, J.V.1    Gómez-Lechón, M.J.2    David, M.3    Fabra, R.4    Trullenque, R.5    Heinrich, P.C.6
  • 41
    • 0025190892 scopus 로고
    • Interleukin-6 and the acute phase response
    • Heinrich PC, Castell JV, Andus T. Interleukin-6 and the acute phase response. Biochem J. 1990;265(3):621–636.
    • (1990) Biochem J , vol.265 , Issue.3 , pp. 621-636
    • Heinrich, P.C.1    Castell, J.V.2    Andus, T.3
  • 42
    • 73249125200 scopus 로고    scopus 로고
    • Fibroblast-like synoviocytes: Key effector cells in rheumatoid arthritis
    • Bartok B, Firestein GS. Fibroblast-like synoviocytes: key effector cells in rheumatoid arthritis. Immunol Rev. 2010;233(1):233–255.
    • (2010) Immunol Rev , vol.233 , Issue.1 , pp. 233-255
    • Bartok, B.1    Firestein, G.S.2
  • 43
    • 33748121115 scopus 로고    scopus 로고
    • Interleukin-6 and chronic inflammation
    • Gabay C. Interleukin-6 and chronic inflammation. Arthritis Res Ther. 2006;8(Suppl 2):S3.
    • (2006) Arthritis Res Ther , vol.8
    • Gabay, C.1
  • 44
    • 28844485738 scopus 로고    scopus 로고
    • The advanced glycation end product pentosidine correlates to IL-6 and other relevant inflammatory markers in rheumatoid arthritis
    • Hein GE, Köhler M, Oelzner P, Stein G, Franke S. The advanced glycation end product pentosidine correlates to IL-6 and other relevant inflammatory markers in rheumatoid arthritis. Rheumatol Int. 2005; 26(2):137–141.
    • (2005) Rheumatol Int , vol.26 , Issue.2 , pp. 137-141
    • Hein, G.E.1    Köhler, M.2    Oelzner, P.3    Stein, G.4    Franke, S.5
  • 45
    • 84890941016 scopus 로고    scopus 로고
    • Synovial joint fluid cytokine levels in hip disease
    • Abe H, Sakai T, Ando W, et al. Synovial joint fluid cytokine levels in hip disease. Rheumatology. 2014;53(1):165–172.
    • (2014) Rheumatology , vol.53 , Issue.1 , pp. 165-172
    • Abe, H.1    Sakai, T.2    Ando, W.3
  • 46
    • 0030760235 scopus 로고    scopus 로고
    • Concentrations and origins of soluble interleukin 6 receptor-alpha in serum and synovial fluid
    • Desgeorges A, Gabay C, Silacci P, et al. Concentrations and origins of soluble interleukin 6 receptor-alpha in serum and synovial fluid. J Rheumatol. 1997;24(8):1510–1516.
    • (1997) J Rheumatol , vol.24 , Issue.8 , pp. 1510-1516
    • Desgeorges, A.1    Gabay, C.2    Silacci, P.3
  • 47
    • 0026537579 scopus 로고
    • Serial estimation of interleukin 6 as a measure of systemic disease in rheumatoid arthritis
    • Dasgupta B, Corkill M, Kirkham B, Gibson T, Panayi G. Serial estimation of interleukin 6 as a measure of systemic disease in rheumatoid arthritis. J Rheumatol. 1992;19(1):22–25.
    • (1992) J Rheumatol , vol.19 , Issue.1 , pp. 22-25
    • Dasgupta, B.1    Corkill, M.2    Kirkham, B.3    Gibson, T.4    Panayi, G.5
  • 48
    • 17644368573 scopus 로고    scopus 로고
    • Interleukin-6: From basic science to medicine – 40 years in immunology
    • Kishimoto T. Interleukin-6: from basic science to medicine – 40 years in immunology. Annu Rev Immunol. 2005;23(1):1–21.
    • (2005) Annu Rev Immunol , vol.23 , Issue.1 , pp. 1-21
    • Kishimoto, T.1
  • 49
    • 27744470765 scopus 로고    scopus 로고
    • A novel mechanism of neutrophil recruitment in a coculture model of the rheumatoid synovium
    • Lally F, Smith E, Filer A, et al. A novel mechanism of neutrophil recruitment in a coculture model of the rheumatoid synovium. Arthritis Rheum. 2005;52(11):3460–3469.
    • (2005) Arthritis Rheum , vol.52 , Issue.11 , pp. 3460-3469
    • Lally, F.1    Smith, E.2    Filer, A.3
  • 50
    • 0037213682 scopus 로고    scopus 로고
    • IL-6: A regulator of the transition from neutrophil to monocyte recruitment during inflammation
    • Kaplanski G, Marin V, Montero-Julian F, Mantovani A, Farnarier C. IL-6: a regulator of the transition from neutrophil to monocyte recruitment during inflammation. Trends Immunol. 2003;24(1):25–29.
    • (2003) Trends Immunol , vol.24 , Issue.1 , pp. 25-29
    • Kaplanski, G.1    Marin, V.2    Montero-Julian, F.3    Mantovani, A.4    Farnarier, C.5
  • 51
    • 54449101331 scopus 로고    scopus 로고
    • IL-6 trans-signalling directly induces RANKL on fibroblast-like synovial cells and is involved in RANKL induction by TNF-and IL-17
    • Hashizume M, Hayakawa N, Mihara M. IL-6 trans-signalling directly induces RANKL on fibroblast-like synovial cells and is involved in RANKL induction by TNF-and IL-17. Rheumatology. 2008;47(11):1635–1640.
    • (2008) Rheumatology , vol.47 , Issue.11 , pp. 1635-1640
    • Hashizume, M.1    Hayakawa, N.2    Mihara, M.3
  • 52
    • 84869797922 scopus 로고    scopus 로고
    • IL-6 trans-signaling via the soluble IL-6 receptor: Importance for the pro-inflammatory activities of IL-6
    • Rose-John S. IL-6 trans-signaling via the soluble IL-6 receptor: importance for the pro-inflammatory activities of IL-6. Int J Biol Sci. 2012;8(9):1237–1247.
    • (2012) Int J Biol Sci , vol.8 , Issue.9 , pp. 1237-1247
    • Rose-John, S.1
  • 53
    • 33748848714 scopus 로고    scopus 로고
    • Interleukin-6 biology is coordinated by membrane-bound and soluble receptors: Role in inflammation and cancer
    • Rose-John S, Scheller J, Elson G, Jones SA. Interleukin-6 biology is coordinated by membrane-bound and soluble receptors: role in inflammation and cancer. J Leukoc Biol. 2006;80(2):227–236.
    • (2006) J Leukoc Biol , vol.80 , Issue.2 , pp. 227-236
    • Rose-John, S.1    Scheller, J.2    Elson, G.3    Jones, S.A.4
  • 54
    • 0032539893 scopus 로고    scopus 로고
    • Sympathetic neurons can produce and respond to interleukin 6
    • März P, Cheng J-G, Gadient RA, et al. Sympathetic neurons can produce and respond to interleukin 6. Proc Natl Acad Sci U S A. 1998; 95(6):3251–3256.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , Issue.6 , pp. 3251-3256
    • März, P.1    Cheng, J.-G.2    Gadient, R.A.3
  • 55
    • 21944443712 scopus 로고    scopus 로고
    • Fast modulation of heat-activated ionic current by proinflammatory interleukin 6 in rat sensory neurons
    • Obreja O, Biasio W, Andratsch M, et al. Fast modulation of heat-activated ionic current by proinflammatory interleukin 6 in rat sensory neurons. Brain. 2005;128(7):1634–1641.
    • (2005) Brain , vol.128 , Issue.7 , pp. 1634-1641
    • Obreja, O.1    Biasio, W.2    Andratsch, M.3
  • 56
    • 0027131202 scopus 로고
    • Recombinant interleukin-6 activates the hypothalamic-pituitary-adrenal axis in humans
    • Mastorakos G, Chrousos GP, Weber JS. Recombinant interleukin-6 activates the hypothalamic-pituitary-adrenal axis in humans. J Clin Endocrinol Metab. 1993;77(6):1690–1694.
    • (1993) J Clin Endocrinol Metab , vol.77 , Issue.6 , pp. 1690-1694
    • Mastorakos, G.1    Chrousos, G.P.2    Weber, J.S.3
  • 60
    • 10844258104 scopus 로고    scopus 로고
    • Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization
    • Nemeth E, Tuttle MS, Powelson J, et al. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science. 2004;306(5704):2090–2093.
    • (2004) Science , vol.306 , Issue.5704 , pp. 2090-2093
    • Nemeth, E.1    Tuttle, M.S.2    Powelson, J.3
  • 61
    • 84876409224 scopus 로고    scopus 로고
    • Anaemia in inflammatory rheumatic diseases
    • Weiss G, Schett G. Anaemia in inflammatory rheumatic diseases. Nat Rev Rheumatol. 2013;9(4):205–215.
    • (2013) Nat Rev Rheumatol , vol.9 , Issue.4 , pp. 205-215
    • Weiss, G.1    Schett, G.2
  • 62
    • 84987896973 scopus 로고    scopus 로고
    • Cardiovascular risk in rheumatoid arthritis: Recent advances in the understanding of the pivotal role of inflammation, risk predictors and the impact of treatment
    • Choy E, Ganeshalingam K, Semb AG, Szekanecz Z, Nurmohamed M. Cardiovascular risk in rheumatoid arthritis: recent advances in the understanding of the pivotal role of inflammation, risk predictors and the impact of treatment. Rheumatology. 2014;53(12):2143–2154.
    • (2014) Rheumatology , vol.53 , Issue.12 , pp. 2143-2154
    • Choy, E.1    Ganeshalingam, K.2    Semb, A.G.3    Szekanecz, Z.4    Nurmohamed, M.5
  • 63
    • 0034704893 scopus 로고    scopus 로고
    • C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women
    • Ridker PM, Hennekens CH, Buring JE, Rifai N. C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. N Engl J Med Overseas Ed. 2000;342(12):836–843.
    • (2000) N Engl J Med Overseas Ed , vol.342 , Issue.12 , pp. 836-843
    • Ridker, P.M.1    Hennekens, C.H.2    Buring, J.E.3    Rifai, N.4
  • 64
    • 85059502198 scopus 로고    scopus 로고
    • RoActemra 20 mg/ml Concentrate for Solution for Infusion
    • Welwynn Garden City: Roche Registration Ltd
    • Roche Registration Ltd. RoActemra 20 mg/ml Concentrate for Solution for Infusion. Welwynn Garden City: Roche Registration Ltd; 2014.
    • (2014)
  • 66
    • 79953680176 scopus 로고    scopus 로고
    • Tocilizumab inhibits structural joint damage in rheumatoid arthritis patients with inadequate responses to methotrexate: Results from the double-blind treatment phase of a randomized placebo-controlled trial of tocilizumab safety and prevention of structu
    • Kremer JM, Blanco R, Brzosko M, et al. Tocilizumab inhibits structural joint damage in rheumatoid arthritis patients with inadequate responses to methotrexate: results from the double-blind treatment phase of a randomized placebo-controlled trial of tocilizumab safety and prevention of structu. Arthritis Rheum. 2011;63(3):609–621.
    • (2011) Arthritis Rheum , vol.63 , Issue.3 , pp. 609-621
    • Kremer, J.M.1    Blanco, R.2    Brzosko, M.3
  • 67
    • 73449118587 scopus 로고    scopus 로고
    • Comparison of tocilizumab monotherapy versus methotrexate monotherapy in patients with moderate to severe rheumatoid arthritis: The AMBITION study
    • Jones G, Sebba A, Gu J, et al. Comparison of tocilizumab monotherapy versus methotrexate monotherapy in patients with moderate to severe rheumatoid arthritis: the AMBITION study. Ann Rheum Dis. 2010; 69(01):88–96.
    • (2010) Ann Rheum Dis , vol.69 , Issue.1 , pp. 88-96
    • Jones, G.1    Sebba, A.2    Gu, J.3
  • 68
    • 52149099504 scopus 로고    scopus 로고
    • IL-6 receptor inhibition with tocilizumab improves treatment outcomes in patients with rheumatoid arthritis refractory to anti-tumour necrosis factor biologicals: Results from a 24-week multicentre randomised placebo-controlled trial
    • Emery P, Keystone E, Tony HP, et al. IL-6 receptor inhibition with tocilizumab improves treatment outcomes in patients with rheumatoid arthritis refractory to anti-tumour necrosis factor biologicals: results from a 24-week multicentre randomised placebo-controlled trial. Ann Rheum Dis. 2008;67(11):1516–1523.
    • (2008) Ann Rheum Dis , vol.67 , Issue.11 , pp. 1516-1523
    • Emery, P.1    Keystone, E.2    Tony, H.P.3
  • 69
    • 54949150604 scopus 로고    scopus 로고
    • Interleukin-6 receptor inhibition with tocilizumab reduces disease activity in rheumatoid arthritis with inadequate response to disease-modifying antirheumatic drugs: The tocilizumab in combination with traditional disease-modifying antirheumatic drug therapy study
    • Genovese MC, McKay JD, Nasonov EL, et al. Interleukin-6 receptor inhibition with tocilizumab reduces disease activity in rheumatoid arthritis with inadequate response to disease-modifying antirheumatic drugs: the tocilizumab in combination with traditional disease-modifying antirheumatic drug therapy study. Arthritis Rheum. 2008; 58(10):2968–2980.
    • (2008) Arthritis Rheum , vol.58 , Issue.10 , pp. 2968-2980
    • Genovese, M.C.1    McKay, J.D.2    Nasonov, E.L.3
  • 70
    • 40749114497 scopus 로고    scopus 로고
    • Effect of interleukin-6 receptor inhibition with tocilizumab in patients with rheumatoid arthritis (OPTION study): A double-blind, placebo-controlled, randomised trial
    • Smolen JS, Beaulieu A, Rubbert-Roth A, et al. Effect of interleukin-6 receptor inhibition with tocilizumab in patients with rheumatoid arthritis (OPTION study): a double-blind, placebo-controlled, randomised trial. Lancet. 2008;371(9617):987–997.
    • (2008) Lancet , vol.371 , Issue.9617 , pp. 987-997
    • Smolen, J.S.1    Beaulieu, A.2    Rubbert-Roth, A.3
  • 71
    • 85007277373 scopus 로고    scopus 로고
    • Subcutaneous tocilizumab versus placebo in combination with disease-modifying antirheumatic drugs in patients with rheumatoid arthritis
    • Kivitz A, Olech E, Borofsky M, et al. Subcutaneous tocilizumab versus placebo in combination with disease-modifying antirheumatic drugs in patients with rheumatoid arthritis. Arthritis Care Res. 2014; 66(11):1653–1661.
    • (2014) Arthritis Care Res , vol.66 , Issue.11 , pp. 1653-1661
    • Kivitz, A.1    Olech, E.2    Borofsky, M.3
  • 72
    • 84889667445 scopus 로고    scopus 로고
    • A randomised, double-blind, parallel-group study of the safety and efficacy of subcutaneous tocilizumab versus intravenous tocilizumab in combination with traditional disease-modifying antirheumatic drugs in patients with moderate to severe rheumatoid arthritis (SUMMACTA study)
    • Burmester GR, Rubbert-Roth A, Cantagrel A, et al. A randomised, double-blind, parallel-group study of the safety and efficacy of subcutaneous tocilizumab versus intravenous tocilizumab in combination with traditional disease-modifying antirheumatic drugs in patients with moderate to severe rheumatoid arthritis (SUMMACTA study). Ann Rheum Dis. 2014;73(1):69–74.
    • (2014) Ann Rheum Dis , vol.73 , Issue.1 , pp. 69-74
    • Burmester, G.R.1    Rubbert-Roth, A.2    Cantagrel, A.3
  • 73
    • 84941695386 scopus 로고    scopus 로고
    • Effectiveness of tocilizumab with and without synthetic disease-modifying antirheumatic drugs in rheumatoid arthritis: Results from a European collaborative study
    • Gabay C, Riek M, Hetland ML, et al. Effectiveness of tocilizumab with and without synthetic disease-modifying antirheumatic drugs in rheumatoid arthritis: results from a European collaborative study. Ann Rheum Dis. 2016;75(7):1336–1342.
    • (2016) Ann Rheum Dis , vol.75 , Issue.7 , pp. 1336-1342
    • Gabay, C.1    Riek, M.2    Hetland, M.L.3
  • 74
    • 85049037392 scopus 로고    scopus 로고
    • Comparative effectiveness of tocilizumab versus TNF inhibitors as monotherapy or in combination with conventional synthetic disease-modifying antirheumatic drugs in patients with rheumatoid arthritis after the use of at least one biologic disease-modifying antirheumatic drug: Analyses from the pan-European TOCERRA register collaboration
    • Lauper K, Nordström DC, Pavelka K, et al. Comparative effectiveness of tocilizumab versus TNF inhibitors as monotherapy or in combination with conventional synthetic disease-modifying antirheumatic drugs in patients with rheumatoid arthritis after the use of at least one biologic disease-modifying antirheumatic drug: analyses from the pan-European TOCERRA register collaboration. Ann Rheum Dis. 2018; 77(9):1276–1282.
    • (2018) Ann Rheum Dis , vol.77 , Issue.9 , pp. 1276-1282
    • Lauper, K.1    Nordström, D.C.2    Pavelka, K.3
  • 75
    • 85030536637 scopus 로고    scopus 로고
    • Real-world experience of tocilizumab in rheumatoid arthritis: Sub-analysis of data from the Italian biologics’ register GISEA
    • Iannone F, Ferraccioli G, Sinigaglia L, et al. Real-world experience of tocilizumab in rheumatoid arthritis: sub-analysis of data from the Italian biologics’ register GISEA. Clin Rheumatol. 2018;37(2):315–321.
    • (2018) Clin Rheumatol , vol.37 , Issue.2 , pp. 315-321
    • Iannone, F.1    Ferraccioli, G.2    Sinigaglia, L.3
  • 76
    • 85047090285 scopus 로고    scopus 로고
    • Tocilizumab after a first-line with anti-TNF in rheumatoid arthritis: A cost-consequence analysis in the Italian setting
    • Iannazzo S, Benucci M, Favalli EG. Tocilizumab after a first-line with anti-TNF in rheumatoid arthritis: a cost-consequence analysis in the Italian setting. Clin Exp Rheumatol. 2018;36(3):479–485.
    • (2018) Clin Exp Rheumatol , vol.36 , Issue.3 , pp. 479-485
    • Iannazzo, S.1    Benucci, M.2    Favalli, E.G.3
  • 77
    • 2642558925 scopus 로고    scopus 로고
    • Treatment of rheumatoid arthritis with humanized anti-interleukin-6 receptor antibody: A multicenter, double-blind, placebo-controlled trial
    • Nishimoto N, Yoshizaki K, Miyasaka N, et al. Treatment of rheumatoid arthritis with humanized anti-interleukin-6 receptor antibody: a multicenter, double-blind, placebo-controlled trial. Arthritis Rheum. 2004;50(6):1761–1769.
    • (2004) Arthritis Rheum , vol.50 , Issue.6 , pp. 1761-1769
    • Nishimoto, N.1    Yoshizaki, K.2    Miyasaka, N.3
  • 78
    • 84855351178 scopus 로고    scopus 로고
    • Efficacy of tocilizumab in patients with moderate to severe active rheumatoid arthritis and a previous inadequate response to disease-modifying antirheumatic drugs: The ROSE study
    • Yazici Y, Curtis JR, Ince A, et al. Efficacy of tocilizumab in patients with moderate to severe active rheumatoid arthritis and a previous inadequate response to disease-modifying antirheumatic drugs: the ROSE study. Ann Rheum Dis. 2012;71(2):198–205.
    • (2012) Ann Rheum Dis , vol.71 , Issue.2 , pp. 198-205
    • Yazici, Y.1    Curtis, J.R.2    Ince, A.3
  • 79
    • 78650907772 scopus 로고    scopus 로고
    • Tocilizumab for rheumatoid arthritis: A Cochrane systematic review
    • Singh JA, Beg S, Lopez-Olivo MA. Tocilizumab for rheumatoid arthritis: a Cochrane systematic review. J Rheumatol. 2011;38(1): 10–20.
    • (2011) J Rheumatol , vol.38 , Issue.1 , pp. 10-20
    • Singh, J.A.1    Beg, S.2    Lopez-Olivo, M.A.3
  • 80
    • 77953122551 scopus 로고    scopus 로고
    • Indirect comparison of tocilizumab and other biologic agents in patients with rheumatoid arthritis and inadequate response to disease-modifying antirheumatic drugs
    • Bergman GJD, Hochberg MC, Boers M, Wintfeld N, Kielhorn A, Jansen JP. Indirect comparison of tocilizumab and other biologic agents in patients with rheumatoid arthritis and inadequate response to disease-modifying antirheumatic drugs. Semin Arthritis Rheum. 2010; 39(6):425–441.
    • (2010) Semin Arthritis Rheum , vol.39 , Issue.6 , pp. 425-441
    • Bergman, G.J.D.1    Hochberg, M.C.2    Boers, M.3    Wintfeld, N.4    Kielhorn, A.5    Jansen, J.P.6
  • 81
    • 84868484220 scopus 로고    scopus 로고
    • Tocilizumab in patients with active rheumatoid arthritis and inadequate responses to DMARDs and/or TNF inhibitors: A large, open-label study close to clinical practice
    • Bykerk VP, Östör AJK, Alvaro-Gracia J, et al. Tocilizumab in patients with active rheumatoid arthritis and inadequate responses to DMARDs and/or TNF inhibitors: a large, open-label study close to clinical practice. Ann Rheum Dis. 2012;71(12):1950–1954.
    • (2012) Ann Rheum Dis , vol.71 , Issue.12 , pp. 1950-1954
    • Bykerk, V.P.1    Östör, A.J.K.2    Alvaro-Gracia, J.3
  • 82
    • 84963741145 scopus 로고    scopus 로고
    • ROUTINE – a prospective, multicentre, non-interventional, observational study to evaluate the safety and effectiveness of intravenous tocilizumab for the treatment of active rheumatoid arthritis in daily practice in Germany
    • Iking-Konert C, von Hinüber U, Richter C, et al. ROUTINE – a prospective, multicentre, non-interventional, observational study to evaluate the safety and effectiveness of intravenous tocilizumab for the treatment of active rheumatoid arthritis in daily practice in Germany. Rheumatology. 2016;55(4):624–635.
    • (2016) Rheumatology , vol.55 , Issue.4 , pp. 624-635
    • Iking-Konert, C.1    von Hinüber, U.2    Richter, C.3
  • 83
    • 84939465460 scopus 로고    scopus 로고
    • Patterns of use and dosing of tocilizumab in the treatment of patients with rheumatoid arthritis in routine clinical practice: The ACT-LIFE study
    • Balsa A, Tovar Beltrán JV, Cáliz Cáliz R, et al. Patterns of use and dosing of tocilizumab in the treatment of patients with rheumatoid arthritis in routine clinical practice: the ACT-LIFE study. Rheumatol Int. 2015;35(9):1525–1534.
    • (2015) Rheumatol Int , vol.35 , Issue.9 , pp. 1525-1534
    • Balsa, A.1    Tovar Beltrán, J.V.2    Cáliz Cáliz, R.3
  • 84
    • 85000995849 scopus 로고    scopus 로고
    • Use and effectiveness of tocilizumab among patients with rheumatoid arthritis: An observational study from the British Society for Rheumatology Biologics Register for rheumatoid arthritis
    • Kihara M, Davies R, Kearsley-Fleet L, et al. Use and effectiveness of tocilizumab among patients with rheumatoid arthritis: an observational study from the British Society for Rheumatology Biologics Register for rheumatoid arthritis. Clin Rheumatol. 2017;36(2):241–250.
    • (2017) Clin Rheumatol , vol.36 , Issue.2 , pp. 241-250
    • Kihara, M.1    Davies, R.2    Kearsley-Fleet, L.3
  • 85
    • 84925491789 scopus 로고    scopus 로고
    • Comparison of tocilizumab and tumour necrosis factor inhibitors in rheumatoid arthritis: A retrospective analysis of 1603 patients managed in routine clinical practice
    • Backhaus M, Kaufmann J, Richter C, et al. Comparison of tocilizumab and tumour necrosis factor inhibitors in rheumatoid arthritis: a retrospective analysis of 1603 patients managed in routine clinical practice. Clin Rheumatol. 2015;34(4):673–681.
    • (2015) Clin Rheumatol , vol.34 , Issue.4 , pp. 673-681
    • Backhaus, M.1    Kaufmann, J.2    Richter, C.3
  • 86
    • 85028929150 scopus 로고    scopus 로고
    • Treatment of rheumatoid arthritis with anti-tumor necrosis factor or tocilizumab therapy as first biologic agent in a global comparative observational Study
    • Choy EH, Bernasconi C, Aassi M, Molina JF, Epis OM. Treatment of rheumatoid arthritis with anti-tumor necrosis factor or tocilizumab therapy as first biologic agent in a global comparative observational Study. Arthritis Care Res. 2017;69(10):1484–1494.
    • (2017) Arthritis Care Res , vol.69 , Issue.10 , pp. 1484-1494
    • Choy, E.H.1    Bernasconi, C.2    Aassi, M.3    Molina, J.F.4    Epis, O.M.5
  • 87
    • 84897146058 scopus 로고    scopus 로고
    • Synovial phenotypes in rheumatoid arthritis correlate with response to biologic therapeutics
    • Dennis G, Holweg CTJ, Kummerfeld SK, et al. Synovial phenotypes in rheumatoid arthritis correlate with response to biologic therapeutics. Arthritis Res Ther. 2014;16(2):R90.
    • (2014) Arthritis Res Ther , vol.16 , Issue.2 , pp. 90
    • Dennis, G.1    Holweg, C.T.J.2    Kummerfeld, S.K.3
  • 88
    • 84871821443 scopus 로고    scopus 로고
    • Obesity and reduction of the response rate to anti-tumor necrosis factor α in rheumatoid arthritis: An approach to a personalized medicine
    • Gremese E, Carletto A, Padovan M, et al. Obesity and reduction of the response rate to anti-tumor necrosis factor α in rheumatoid arthritis: an approach to a personalized medicine. Arthritis Care Res. 2013;65(1): 94–100.
    • (2013) Arthritis Care Res , vol.65 , Issue.1 , pp. 94-100
    • Gremese, E.1    Carletto, A.2    Padovan, M.3
  • 89
    • 33751416149 scopus 로고    scopus 로고
    • Predictors of response to anti-TNF-alpha therapy among patients with rheumatoid arthritis: Results from the British Society for Rheumatology Biologics Register
    • Hyrich KL, Watson KD, Silman AJ, Symmons DP; The BSR Biologics Register. Predictors of response to anti-TNF-alpha therapy among patients with rheumatoid arthritis: results from the British Society for Rheumatology Biologics Register. Rheumatology. 2006;45(12): 1558–1565.
    • (2006) Rheumatology , vol.45 , Issue.12 , pp. 1558-1565
    • Hyrich, K.L.1    Watson, K.D.2    Silman, A.J.3    Symmons, D.P.4
  • 90
    • 84941662740 scopus 로고    scopus 로고
    • Impact of baseline anti-cyclic citrullinated peptide-2 antibody concentration on efficacy outcomes following treatment with subcutaneous abatacept or adalimumab: 2-year results from the AMPLE trial
    • Sokolove J, Schiff M, Fleischmann R, et al. Impact of baseline anti-cyclic citrullinated peptide-2 antibody concentration on efficacy outcomes following treatment with subcutaneous abatacept or adalimumab: 2-year results from the AMPLE trial. Ann Rheum Dis. 2016;75(4):709–714.
    • (2016) Ann Rheum Dis , vol.75 , Issue.4 , pp. 709-714
    • Sokolove, J.1    Schiff, M.2    Fleischmann, R.3
  • 91
    • 84873736397 scopus 로고    scopus 로고
    • Effect of baseline rheumatoid factor and anticitrullinated peptide antibody serotype on rituximab clinical response: A meta-analysis
    • Isaacs JD, Cohen SB, Emery P, et al. Effect of baseline rheumatoid factor and anticitrullinated peptide antibody serotype on rituximab clinical response: a meta-analysis. Ann Rheum Dis. 2013;72(3):329–336.
    • (2013) Ann Rheum Dis , vol.72 , Issue.3 , pp. 329-336
    • Isaacs, J.D.1    Cohen, S.B.2    Emery, P.3
  • 92
    • 84978416108 scopus 로고    scopus 로고
    • Anti-citrullinated peptide antibodies and their value for predicting responses to biologic agents: A review
    • Martin-Mola E, Balsa A, García-Vicuna R, et al. Anti-citrullinated peptide antibodies and their value for predicting responses to biologic agents: a review. Rheumatol Int. 2016;36(8):1043–1063.
    • (2016) Rheumatol Int , vol.36 , Issue.8 , pp. 1043-1063
    • Martin-Mola, E.1    Balsa, A.2    García-Vicuna, R.3
  • 93
    • 84940560142 scopus 로고    scopus 로고
    • Response to tocilizumab in rheumatoid arthritis is not influenced by the body mass index of the patient
    • Pers Y-M, Godfrin-Valnet M, Lambert J, et al. Response to tocilizumab in rheumatoid arthritis is not influenced by the body mass index of the patient. J Rheumatol. 2015;42(4):580–584.
    • (2015) J Rheumatol , vol.42 , Issue.4 , pp. 580-584
    • Pers, Y.-M.1    Godfrin-Valnet, M.2    Lambert, J.3
  • 94
    • 85044396948 scopus 로고    scopus 로고
    • FRI0163 smoking status does not seem to affect tocilizumab efficacy in RA patients
    • Theander E, Proven A, Fallang A, Svelander L, Trollmo T. FRI0163 smoking status does not seem to affect tocilizumab efficacy in RA patients. Ann Rheum Dis. 2015;74(Suppl 2):482.
    • (2015) Ann Rheum Dis , vol.74 , pp. 482
    • Theander, E.1    Proven, A.2    Fallang, A.3    Svelander, L.4    Trollmo, T.5
  • 95
    • 84959552894 scopus 로고    scopus 로고
    • Predictive factors for induction of remission in patients with active rheumatoid arthritis treated with tocilizumab in clinical practice
    • Narváez J, Magallares B, Díaz Torné C, et al. Predictive factors for induction of remission in patients with active rheumatoid arthritis treated with tocilizumab in clinical practice. Semin Arthritis Rheum. 2016; 45(4):386–390.
    • (2016) Semin Arthritis Rheum , vol.45 , Issue.4 , pp. 386-390
    • Narváez, J.1    Magallares, B.2    Díaz Torné, C.3
  • 96
    • 84969959750 scopus 로고    scopus 로고
    • Relationship between baseline and early changes in c-reactive protein and interleukin-6 levels and clinical response to tocilizumab in rheumatoid arthritis
    • Wang J, Devenport J, Low JM, Yu D, Hitraya E. Relationship between baseline and early changes in c-reactive protein and interleukin-6 levels and clinical response to tocilizumab in rheumatoid arthritis. Arthritis Care Res. 2016;68(6):882–885.
    • (2016) Arthritis Care Res , vol.68 , Issue.6 , pp. 882-885
    • Wang, J.1    Devenport, J.2    Low, J.M.3    Yu, D.4    Hitraya, E.5
  • 97
    • 85034055565 scopus 로고    scopus 로고
    • The combination of IL-6 and its soluble receptor is associated with the response of rheumatoid arthritis patients to tocilizumab
    • Diaz-Torne C, Ortiz MDA, Moya P, et al. The combination of IL-6 and its soluble receptor is associated with the response of rheumatoid arthritis patients to tocilizumab. Semin Arthritis Rheum. 2018; 47(6):757–764.
    • (2018) Semin Arthritis Rheum , vol.47 , Issue.6 , pp. 757-764
    • Diaz-Torne, C.1    Ortiz, M.D.A.2    Moya, P.3
  • 98
    • 85037988617 scopus 로고    scopus 로고
    • A novel scoring system based on common laboratory tests predicts the efficacy of TNF-inhibitor and IL-6 targeted therapy in patients with rheumatoid arthritis: A retrospective, multicenter observational study
    • Nakagawa J, Koyama Y, Kawakami A, et al. A novel scoring system based on common laboratory tests predicts the efficacy of TNF-inhibitor and IL-6 targeted therapy in patients with rheumatoid arthritis: a retrospective, multicenter observational study. Arthritis Res Ther. 2017;19(1):185.
    • (2017) Arthritis Res Ther , vol.19 , Issue.1 , pp. 185
    • Nakagawa, J.1    Koyama, Y.2    Kawakami, A.3
  • 99
    • 85026289180 scopus 로고    scopus 로고
    • International consensus: What else can we do to improve diagnosis and therapeutic strategies in patients affected by autoimmune rheumatic diseases (rheumatoid arthritis, spondyloarthritides, systemic sclerosis, systemic lupus erythematosus, antiphospholipid syndrome and Sjogren’s syndrome)?
    • Giacomelli R, Afeltra A, Alunno A, et al. International consensus: what else can we do to improve diagnosis and therapeutic strategies in patients affected by autoimmune rheumatic diseases (rheumatoid arthritis, spondyloarthritides, systemic sclerosis, systemic lupus erythematosus, antiphospholipid syndrome and Sjogren’s syndrome)? Autoimmun Rev. 2017;16(9):911–924.
    • (2017) Autoimmun Rev , vol.16 , Issue.9 , pp. 911-924
    • Giacomelli, R.1    Afeltra, A.2    Alunno, A.3
  • 100
    • 85008428237 scopus 로고    scopus 로고
    • Factors influencing the choice of first-and second-line biologic therapy for the treatment of rheumatoid arthritis: Real-life data from the Italian LORHEN Registry
    • Monti S, Klersy C, Gorla R, et al. Factors influencing the choice of first-and second-line biologic therapy for the treatment of rheumatoid arthritis: real-life data from the Italian LORHEN Registry. Clin Rheumatol. 2017;36(4):753–761.
    • (2017) Clin Rheumatol , vol.36 , Issue.4 , pp. 753-761
    • Monti, S.1    Klersy, C.2    Gorla, R.3
  • 101
    • 84946887746 scopus 로고    scopus 로고
    • Tocilizumab in early progressive rheumatoid arthritis: FUNCTION, a randomised controlled trial
    • Burmester GR, Rigby WF, van Vollenhoven RF, et al. Tocilizumab in early progressive rheumatoid arthritis: FUNCTION, a randomised controlled trial. Ann Rheum Dis. 2016;75(6):1081–1091.
    • (2016) Ann Rheum Dis , vol.75 , Issue.6 , pp. 1081-1091
    • Burmester, G.R.1    Rigby, W.F.2    van Vollenhoven, R.F.3
  • 102
    • 85020718307 scopus 로고    scopus 로고
    • Tocilizumab combination therapy or monotherapy or methotrexate monotherapy in methotrexate-naive patients with early rheumatoid arthritis: 2-year clinical and radiographic results from the randomised, placebo-controlled FUNCTION trial
    • Burmester GR, Rigby WF, van Vollenhoven RF, et al. Tocilizumab combination therapy or monotherapy or methotrexate monotherapy in methotrexate-naive patients with early rheumatoid arthritis: 2-year clinical and radiographic results from the randomised, placebo-controlled FUNCTION trial. Ann Rheum Dis. 2017;76(7): 1279–1284.
    • (2017) Ann Rheum Dis , vol.76 , Issue.7 , pp. 1279-1284
    • Burmester, G.R.1    Rigby, W.F.2    van Vollenhoven, R.F.3
  • 103
    • 84973539391 scopus 로고    scopus 로고
    • Early rheumatoid arthritis treated with tocilizumab, methotrexate, or their combination (U-Act-Early): A multicentre, randomised, double-blind, double-dummy, strategy trial
    • Bijlsma JWJ, Welsing PMJ, Woodworth TG, et al. Early rheumatoid arthritis treated with tocilizumab, methotrexate, or their combination (U-Act-Early): a multicentre, randomised, double-blind, double-dummy, strategy trial. Lancet. 2016;388(10042): 343–355.
    • (2016) Lancet , vol.388 , Issue.10042 , pp. 343-355
    • Bijlsma, J.W.J.1    Welsing, P.M.J.2    Woodworth, T.G.3
  • 104
    • 84908546592 scopus 로고    scopus 로고
    • Methotrexate for the treatment of rheumatoid arthritis in the biologic era: Still an “anchor” drug?
    • Favalli EG, Biggioggero M, Meroni PL. Methotrexate for the treatment of rheumatoid arthritis in the biologic era: still an “anchor” drug? Autoimmun Rev. 2014;13(11):1102–1108.
    • (2014) Autoimmun Rev , vol.13 , Issue.11 , pp. 1102-1108
    • Favalli, E.G.1    Biggioggero, M.2    Meroni, P.L.3
  • 105
    • 85047835185 scopus 로고    scopus 로고
    • The role of concomitant methotrexate dosage and maintenance over time in the therapy of rheumatoid arthritis patients treated with adalimumab or etanercept: Retrospective analysis of a local registry
    • Favalli EG, Becciolini A, Biggioggero M, et al. The role of concomitant methotrexate dosage and maintenance over time in the therapy of rheumatoid arthritis patients treated with adalimumab or etanercept: retrospective analysis of a local registry. Drug Des Devel Ther. 2018; 12:1421–1429.
    • (2018) Drug Des Devel Ther , vol.12 , pp. 1421-1429
    • Favalli, E.G.1    Becciolini, A.2    Biggioggero, M.3
  • 106
    • 85034760402 scopus 로고    scopus 로고
    • Immunogenicity and loss of response to TNF inhibitors: Implications for rheumatoid arthritis treatment
    • Kalden JR, Schulze-Koops H. Immunogenicity and loss of response to TNF inhibitors: implications for rheumatoid arthritis treatment. Nat Rev Rheumatol. 2017;13(12):707–718.
    • (2017) Nat Rev Rheumatol , vol.13 , Issue.12 , pp. 707-718
    • Kalden, J.R.1    Schulze-Koops, H.2
  • 107
    • 84887426711 scopus 로고    scopus 로고
    • Biologic and oral disease-modifying antirheumatic drug monotherapy in rheumatoid arthritis
    • Emery P, Sebba A, Huizinga TW. Biologic and oral disease-modifying antirheumatic drug monotherapy in rheumatoid arthritis. Ann Rheum Dis. 2013;72(12):1897–1904.
    • (2013) Ann Rheum Dis , vol.72 , Issue.12 , pp. 1897-1904
    • Emery, P.1    Sebba, A.2    Huizinga, T.W.3
  • 108
    • 85019765125 scopus 로고    scopus 로고
    • Monotherapy with biologic disease-modifying anti-rheumatic drugs in rheumatoid arthritis
    • Choy E, Aletaha D, Behrens F, et al. Monotherapy with biologic disease-modifying anti-rheumatic drugs in rheumatoid arthritis. Rheumatology. 2017;56(5):689–697.
    • (2017) Rheumatology , vol.56 , Issue.5 , pp. 689-697
    • Choy, E.1    Aletaha, D.2    Behrens, F.3
  • 109
    • 85011661276 scopus 로고    scopus 로고
    • Five-year efficacy and safety of tocilizumab monotherapy in patients with rheumatoid arthritis who were methotrexate-and biologic-naive or free of methotrexate for 6 months: The AMBITION Study
    • Jones G, Wallace T, Mcintosh MJ, Brockwell L, Gómez-Reino JJ, Sebba A. Five-year efficacy and safety of tocilizumab monotherapy in patients with rheumatoid arthritis who were methotrexate-and biologic-naive or free of methotrexate for 6 months: the AMBITION Study. J Rheumatol. 2017;44(2):142–146.
    • (2017) J Rheumatol , vol.44 , Issue.2 , pp. 142-146
    • Jones, G.1    Wallace, T.2    McIntosh, M.J.3    Brockwell, L.4    Gómez-Reino, J.J.5    Sebba, A.6
  • 110
    • 84897971056 scopus 로고    scopus 로고
    • Clinical, radiographic and immunogenic effects after 1 year of tocilizumab-based treatment strategies in rheumatoid arthritis: The ACT-RAY study
    • Dougados M, Kissel K, Conaghan PG, et al. Clinical, radiographic and immunogenic effects after 1 year of tocilizumab-based treatment strategies in rheumatoid arthritis: the ACT-RAY study. Ann Rheum Dis. 2014;73(5):803–809.
    • (2014) Ann Rheum Dis , vol.73 , Issue.5 , pp. 803-809
    • Dougados, M.1    Kissel, K.2    Conaghan, P.G.3
  • 111
    • 85043325180 scopus 로고    scopus 로고
    • Subcutaneous tocilizumab in rheumatoid arthritis: Findings from the common-framework phase 4 study programme TOZURA conducted in 22 countries
    • Choy E, Caporali R, Xavier R, et al. Subcutaneous tocilizumab in rheumatoid arthritis: findings from the common-framework phase 4 study programme TOZURA conducted in 22 countries. Rheumatology. 2018;57(6):1129.
    • (2018) Rheumatology , vol.57 , Issue.6 , pp. 1129
    • Choy, E.1    Caporali, R.2    Xavier, R.3
  • 112
    • 85048307092 scopus 로고    scopus 로고
    • Discriminating phenotypic signatures identified for tocilizumab, adalimumab, and tofacitinib monotherapy and their combinations with methotrexate
    • O’Mahony A, John MR, Cho H, Hashizume M, Choy EH. Discriminating phenotypic signatures identified for tocilizumab, adalimumab, and tofacitinib monotherapy and their combinations with methotrexate. J Transl Med. 2018;16(1):156.
    • (2018) J Transl Med , vol.16 , Issue.1 , pp. 156
    • O’Mahony, A.1    John, M.R.2    Cho, H.3    Hashizume, M.4    Choy, E.H.5
  • 113
    • 26444457711 scopus 로고    scopus 로고
    • Incorporating the patient perspective into outcome assessment in rheumatoid arthritis – progress at OMERACT 7
    • Kirwan JR, Hewlett SE, Heiberg T, et al. Incorporating the patient perspective into outcome assessment in rheumatoid arthritis – progress at OMERACT 7. J Rheumatol. 2005;32(11):2250–2256.
    • (2005) J Rheumatol , vol.32 , Issue.11 , pp. 2250-2256
    • Kirwan, J.R.1    Hewlett, S.E.2    Heiberg, T.3
  • 115
    • 85034612687 scopus 로고    scopus 로고
    • Impact of tocilizumab monotherapy on patient-reported outcomes in patients with rheumatoid arthritis from two randomised controlled trials
    • Strand V, Michalska M, Birchwood C, et al. Impact of tocilizumab monotherapy on patient-reported outcomes in patients with rheumatoid arthritis from two randomised controlled trials. RMD Open. 2017;3(2):e000496.
    • (2017) RMD Open , vol.3 , Issue.2 , pp. e000496
    • Strand, V.1    Michalska, M.2    Birchwood, C.3
  • 116
    • 85048829973 scopus 로고    scopus 로고
    • Impact of tocilizumab administered intravenously or subcutaneously on patient-reported quality-of-life outcomes in patients with rheumatoid arthritis
    • Strand V, Michalska M, Birchwood C, et al. Impact of tocilizumab administered intravenously or subcutaneously on patient-reported quality-of-life outcomes in patients with rheumatoid arthritis. RMD Open. 2018;4(1):e000602.
    • (2018) RMD Open , vol.4 , Issue.1 , pp. e000602
    • Strand, V.1    Michalska, M.2    Birchwood, C.3
  • 117
    • 79953319576 scopus 로고    scopus 로고
    • Effectiveness and safety of the interleukin 6-receptor antagonist tocilizumab after 4 and 24 weeks in patients with active rheumatoid arthritis: The first phase IIIb real-life study (TAMARA)
    • Burmester GR, Feist E, Kellner H, Braun J, Iking-Konert C, Rubbert-Roth A. Effectiveness and safety of the interleukin 6-receptor antagonist tocilizumab after 4 and 24 weeks in patients with active rheumatoid arthritis: the first phase IIIb real-life study (TAMARA). Ann Rheum Dis. 2011;70(5):755–759.
    • (2011) Ann Rheum Dis , vol.70 , Issue.5 , pp. 755-759
    • Burmester, G.R.1    Feist, E.2    Kellner, H.3    Braun, J.4    Iking-Konert, C.5    Rubbert-Roth, A.6
  • 118
    • 84888590842 scopus 로고    scopus 로고
    • Effect of tocilizumab on haematological markers implicates interleukin-6 signalling in the anaemia of rheumatoid arthritis
    • Isaacs JD, Harari O, Kobold U, Lee JS, Bernasconi C. Effect of tocilizumab on haematological markers implicates interleukin-6 signalling in the anaemia of rheumatoid arthritis. Arthritis Res Ther. 2013; 15(6):R204.
    • (2013) Arthritis Res Ther , vol.15 , Issue.6 , pp. R204
    • Isaacs, J.D.1    Harari, O.2    Kobold, U.3    Lee, J.S.4    Bernasconi, C.5
  • 119
    • 85029718857 scopus 로고    scopus 로고
    • Effectiveness of biologic and non-biologic antirheumatic drugs on anaemia markers in 153,788 patients with rheumatoid arthritis: New evidence from real-world data
    • Paul SK, Montvida O, Best JH, Gale S, Pethoe-Schramm A, Sarsour K. Effectiveness of biologic and non-biologic antirheumatic drugs on anaemia markers in 153,788 patients with rheumatoid arthritis: new evidence from real-world data. Semin Arthritis Rheum. 2018;47(4): 478–484.
    • (2018) Semin Arthritis Rheum , vol.47 , Issue.4 , pp. 478-484
    • Paul, S.K.1    Montvida, O.2    Best, J.H.3    Gale, S.4    Pethoe-Schramm, A.5    Sarsour, K.6
  • 121
    • 64949111191 scopus 로고    scopus 로고
    • Interpreting lipid levels in the context of high-grade inflammatory states with a focus on rheumatoid arthritis: A challenge to conventional cardiovascular risk actions
    • Choy E, Sattar N. Interpreting lipid levels in the context of high-grade inflammatory states with a focus on rheumatoid arthritis: a challenge to conventional cardiovascular risk actions. Ann Rheum Dis. 2009; 68(4):460–469.
    • (2009) Ann Rheum Dis , vol.68 , Issue.4 , pp. 460-469
    • Choy, E.1    Sattar, N.2
  • 122
    • 77956646068 scopus 로고    scopus 로고
    • Safety and efficacy profiles of tocilizumab monotherapy in Japanese patients with rheumatoid arthritis: Meta-analysis of six initial trials and five long-term extensions
    • Nishimoto N, Ito K, Takagi N. Safety and efficacy profiles of tocilizumab monotherapy in Japanese patients with rheumatoid arthritis: meta-analysis of six initial trials and five long-term extensions. Mod Rheumatol. 2010;20(3):222–232.
    • (2010) Mod Rheumatol , vol.20 , Issue.3 , pp. 222-232
    • Nishimoto, N.1    Ito, K.2    Takagi, N.3
  • 123
    • 84922780682 scopus 로고    scopus 로고
    • An evaluation of risk factors for major adverse cardiovascular events during tocilizumab therapy
    • Rao VU, Pavlov A, Klearman M, et al. An evaluation of risk factors for major adverse cardiovascular events during tocilizumab therapy. Arthritis Rheumatol. 2015;67(2):372–380.
    • (2015) Arthritis Rheumatol , vol.67 , Issue.2 , pp. 372-380
    • Rao, V.U.1    Pavlov, A.2    Klearman, M.3
  • 124
    • 85026803404 scopus 로고    scopus 로고
    • Comparative cardiovascular safety of tocilizumab vs etanercept in rheumatoid arthritis: Results of a randomized, parallel-group, multicenter, noninferiority, phase 4 clinical trial
    • Giles JT, Sattar N, Gabriel SE, et al. Comparative cardiovascular safety of tocilizumab vs etanercept in rheumatoid arthritis: results of a randomized, parallel-group, multicenter, noninferiority, phase 4 clinical trial. Arthritis Rheumatol. 2016;68(Suppl 10):4357–4359.
    • (2016) Arthritis Rheumatol , vol.68 , pp. 4357-4359
    • Giles, J.T.1    Sattar, N.2    Gabriel, S.E.3
  • 125
    • 85045642431 scopus 로고    scopus 로고
    • Comparison of the risks of hospitalisation for cardiovascular events in patients with rheumatoid arthritis treated with tocilizumab and etanercept
    • Generali E, Carrara G, Selmi C, et al. Comparison of the risks of hospitalisation for cardiovascular events in patients with rheumatoid arthritis treated with tocilizumab and etanercept. Clin Exp Rheumatol. 2018;36(2):310–313.
    • (2018) Clin Exp Rheumatol , vol.36 , Issue.2 , pp. 310-313
    • Generali, E.1    Carrara, G.2    Selmi, C.3
  • 126
    • 85018971196 scopus 로고    scopus 로고
    • Cardiovascular safety of tocilizumab versus tumor necrosis factor inhibitors in patients with rheumatoid arthritis: A multi-database cohort study
    • Kim SC, Solomon DH, Rogers JR, et al. Cardiovascular safety of tocilizumab versus tumor necrosis factor inhibitors in patients with rheumatoid arthritis: a multi-database cohort study. Arthritis Rheumatol. 2017;69(6):1154–1164.
    • (2017) Arthritis Rheumatol , vol.69 , Issue.6 , pp. 1154-1164
    • Kim, S.C.1    Solomon, D.H.2    Rogers, J.R.3
  • 127
    • 85045477366 scopus 로고    scopus 로고
    • No difference in cardiovascular risk of tocilizumab versus abatacept for rheumatoid arthritis: A multi-database cohort study
    • Epub March 22, 2018
    • Kim SC, Solomon DH, Rogers JR, et al. No difference in cardiovascular risk of tocilizumab versus abatacept for rheumatoid arthritis: a multi-database cohort study. Semin Arthritis Rheum. 2018. Epub March 22, 2018.
    • (2018) Semin Arthritis Rheum
    • Kim, S.C.1    Solomon, D.H.2    Rogers, J.R.3
  • 128
    • 85042202027 scopus 로고    scopus 로고
    • IL-6 receptor blockade ameliorates diabetic nephropathy via inhibiting inflammasome in mice
    • Wu R, Liu X, Yin J, et al. IL-6 receptor blockade ameliorates diabetic nephropathy via inhibiting inflammasome in mice. Metabolism. 2018;83:18–24.
    • (2018) Metabolism , vol.83 , pp. 18-24
    • Wu, R.1    Liu, X.2    Yin, J.3
  • 129
    • 84926337175 scopus 로고    scopus 로고
    • Significant effects of biologic therapy on lipid profiles and insulin resistance in patients with rheumatoid arthritis
    • Chen DY, Chen YM, Hsieh TY, Hsieh CW, Lin CC, Lan JL. Significant effects of biologic therapy on lipid profiles and insulin resistance in patients with rheumatoid arthritis. Arthritis Res Ther. 2015; 17:52.
    • (2015) Arthritis Res Ther , vol.17 , pp. 52
    • Chen, D.Y.1    Chen, Y.M.2    Hsieh, T.Y.3    Hsieh, C.W.4    Lin, C.C.5    Lan, J.L.6
  • 130
    • 78650781728 scopus 로고    scopus 로고
    • Effects of inhibition of interleukin-6 signalling on insulin sensitivity and lipoprotein (A) levels in human subjects with rheumatoid diseases
    • Schultz O, Oberhauser F, Saech J, et al. Effects of inhibition of interleukin-6 signalling on insulin sensitivity and lipoprotein (a) levels in human subjects with rheumatoid diseases. PLoS One. 2010;5(12):e14328.
    • (2010) Plos One , vol.5 , Issue.12
    • Schultz, O.1    Oberhauser, F.2    Saech, J.3
  • 131
    • 84954317028 scopus 로고    scopus 로고
    • Efficacy and safety of subcutaneous tocilizumab versus intravenous tocilizumab in combination with traditional DMARDs in patients with RA at week 97 (SUMMACTA)
    • Burmester GR, Rubbert-Roth A, Cantagrel A, et al. Efficacy and safety of subcutaneous tocilizumab versus intravenous tocilizumab in combination with traditional DMARDs in patients with RA at week 97 (SUMMACTA). Ann Rheum Dis. 2016;75(1):68–74.
    • (2016) Ann Rheum Dis , vol.75 , Issue.1 , pp. 68-74
    • Burmester, G.R.1    Rubbert-Roth, A.2    Cantagrel, A.3
  • 132
    • 84876259815 scopus 로고    scopus 로고
    • Longterm safety and efficacy of tocilizumab in patients with rheumatoid arthritis: A cumulative analysis of up to 4.6 years of exposure
    • Genovese MC, Rubbert-Roth A, Smolen JS, et al. Longterm safety and efficacy of tocilizumab in patients with rheumatoid arthritis: a cumulative analysis of up to 4.6 years of exposure. J Rheumatol. 2013;40(6): 768–780.
    • (2013) J Rheumatol , vol.40 , Issue.6 , pp. 768-780
    • Genovese, M.C.1    Rubbert-Roth, A.2    Smolen, J.S.3
  • 133
    • 84988417747 scopus 로고    scopus 로고
    • Malignancy rates in patients with rheumatoid arthritis treated with tocilizumab
    • Rubbert-Roth A, Sebba A, Brockwell L, et al. Malignancy rates in patients with rheumatoid arthritis treated with tocilizumab. RMD Open. 2016;2(1):e000213.
    • (2016) RMD Open , vol.2 , Issue.1
    • Rubbert-Roth, A.1    Sebba, A.2    Brockwell, L.3
  • 134
    • 79953018875 scopus 로고    scopus 로고
    • Adverse effects of biologics: A network meta-analysis and Cochrane overview
    • Singh JA, Wells GA, Christensen R, et al. Adverse effects of biologics: a network meta-analysis and Cochrane overview. Cochrane Database Syst Rev. 2011;(2):CD008794.
    • (2011) Cochrane Database Syst Rev , Issue.2
    • Singh, J.A.1    Wells, G.A.2    Christensen, R.3
  • 135
    • 85020229162 scopus 로고    scopus 로고
    • Biologic disease-modifying antirheumatic drug (BDMARD)-induced neutropenia: A registry from a retrospective cohort of patients with rheumatic diseases treated with 3 classes of intravenous bDMARD
    • Espinoza F, Le Blay P, Combe B. Biologic disease-modifying antirheumatic drug (bDMARD)-induced neutropenia: a registry from a retrospective cohort of patients with rheumatic diseases treated with 3 classes of intravenous bDMARD. J Rheumatol. 2017;44(6): 844–849.
    • (2017) J Rheumatol , vol.44 , Issue.6 , pp. 844-849
    • Espinoza, F.1    Le Blay, P.2    Combe, B.3
  • 136
    • 84978805792 scopus 로고    scopus 로고
    • Risk for lower intestinal perforations in patients with rheumatoid arthritis treated with tocilizumab in comparison to treatment with other biologic or conventional synthetic DMARDs
    • Strangfeld A, Richter A, Siegmund B, et al. Risk for lower intestinal perforations in patients with rheumatoid arthritis treated with tocilizumab in comparison to treatment with other biologic or conventional synthetic DMARDs. Ann Rheum Dis. 2017;76(3):504–510.
    • (2017) Ann Rheum Dis , vol.76 , Issue.3 , pp. 504-510
    • Strangfeld, A.1    Richter, A.2    Siegmund, B.3
  • 137
    • 84992623468 scopus 로고    scopus 로고
    • Brief report: Risk of gastrointestinal perforation among rheumatoid arthritis patients receiving tofacitinib, tocilizumab, or other biologic treatments
    • Xie F, Yun H, Bernatsky S, Curtis JR. Brief report: risk of gastrointestinal perforation among rheumatoid arthritis patients receiving tofacitinib, tocilizumab, or other biologic treatments. Arthritis Rheumatol. 2016;68(11):2612–2617.
    • (2016) Arthritis Rheumatol , vol.68 , Issue.11 , pp. 2612-2617
    • Xie, F.1    Yun, H.2    Bernatsky, S.3    Curtis, J.R.4
  • 138
    • 85034703112 scopus 로고    scopus 로고
    • Incidence of gastrointestinal perforations in patients with rheumatoid arthritis treated with tocilizumab from clinical trial, postmarketing, and real-world data sources
    • Monemi S, Berber E, Sarsour K, et al. Incidence of gastrointestinal perforations in patients with rheumatoid arthritis treated with tocilizumab from clinical trial, postmarketing, and real-world data sources. Rheumatol Ther. 2016;3(2):337–352.
    • (2016) Rheumatol Ther , vol.3 , Issue.2 , pp. 337-352
    • Monemi, S.1    Berber, E.2    Sarsour, K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.