메뉴 건너뛰기




Volumn 47, Issue 6, 2018, Pages 757-764

The combination of IL-6 and its soluble receptor is associated with the response of rheumatoid arthritis patients to tocilizumab

Author keywords

IL 6; Rheumatoid arthritis; sIL 6R; Tocilizumab

Indexed keywords

C REACTIVE PROTEIN; INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR; TOCILIZUMAB; ANTIRHEUMATIC AGENT; MONOCLONAL ANTIBODY;

EID: 85034055565     PISSN: 00490172     EISSN: 1532866X     Source Type: Journal    
DOI: 10.1016/j.semarthrit.2017.10.022     Document Type: Article
Times cited : (41)

References (35)
  • 1
    • 0028799973 scopus 로고
    • Regulation of the balance of cytokine production and the signal transducer and activator of transcription (STAT) transcription factor activity by cytokines and inflammatory synovial fluids
    • Wang, F., Sengupta, T.K., Zhong, Z., Ivashkiv, L.B., Regulation of the balance of cytokine production and the signal transducer and activator of transcription (STAT) transcription factor activity by cytokines and inflammatory synovial fluids. J Exp Med 182 (1995), 1825–1831.
    • (1995) J Exp Med , vol.182 , pp. 1825-1831
    • Wang, F.1    Sengupta, T.K.2    Zhong, Z.3    Ivashkiv, L.B.4
  • 2
    • 77954096689 scopus 로고    scopus 로고
    • IL-6: regulator of Treg/Th17 balance
    • Kimura, A., Kishimoto, T., IL-6: regulator of Treg/Th17 balance. Eur J Immunol 40 (2010), 1830–1835.
    • (2010) Eur J Immunol , vol.40 , pp. 1830-1835
    • Kimura, A.1    Kishimoto, T.2
  • 3
    • 84928568835 scopus 로고    scopus 로고
    • IL-6 as a keystone cytokine in health and disease
    • Hunter, C.A., Jones, S.A., IL-6 as a keystone cytokine in health and disease. Nat Immunol 16 (2015), 448–457.
    • (2015) Nat Immunol , vol.16 , pp. 448-457
    • Hunter, C.A.1    Jones, S.A.2
  • 4
    • 85028203484 scopus 로고    scopus 로고
    • Interleukin-6 and its receptors: a highly regulated and dynamic system
    • Wolf, J., Rose-John, S., Garbers, C., Interleukin-6 and its receptors: a highly regulated and dynamic system. Cytokine 70 (2014), 11–20.
    • (2014) Cytokine , vol.70 , pp. 11-20
    • Wolf, J.1    Rose-John, S.2    Garbers, C.3
  • 5
    • 33748848714 scopus 로고    scopus 로고
    • Interleukin-6 biology is coordinated by membrane-bound and soluble receptors: role in inflammation and cancer
    • Rose-John, S., Scheller, J., Elson, G., Jones, S.A., Interleukin-6 biology is coordinated by membrane-bound and soluble receptors: role in inflammation and cancer. J Leukoc Biol 80 (2006), 227–236.
    • (2006) J Leukoc Biol , vol.80 , pp. 227-236
    • Rose-John, S.1    Scheller, J.2    Elson, G.3    Jones, S.A.4
  • 6
    • 84869797922 scopus 로고    scopus 로고
    • IL-6 trans-signaling via the soluble IL-6 receptor: importance for the pro-inflammatory activities of IL-6
    • Rose-John, S., IL-6 trans-signaling via the soluble IL-6 receptor: importance for the pro-inflammatory activities of IL-6. Int J Biol Sci 8 (2012), 1237–1247.
    • (2012) Int J Biol Sci , vol.8 , pp. 1237-1247
    • Rose-John, S.1
  • 7
    • 84877275257 scopus 로고    scopus 로고
    • Tocilizumab monotherapy versus adalimumab monotherapy for treatment of rheumatoid arthritis (ADACTA): a randomised, double-blind, controlled phase 4 trial
    • Gabay, C., Emery, P., van Vollenhoven, R., Dikranian, A., Alten, R., Pavelka, K., et al. Tocilizumab monotherapy versus adalimumab monotherapy for treatment of rheumatoid arthritis (ADACTA): a randomised, double-blind, controlled phase 4 trial. Lancet 381 (2013), 1541–1550.
    • (2013) Lancet , vol.381 , pp. 1541-1550
    • Gabay, C.1    Emery, P.2    van Vollenhoven, R.3    Dikranian, A.4    Alten, R.5    Pavelka, K.6
  • 8
    • 54949150604 scopus 로고    scopus 로고
    • Interleukin-6 receptor inhibition with tocilizumab reduces disease activity in rheumatoid arthritis with inadequate response to disease-modifying antirheumatic drugs: the tocilizumab in combination with traditional disease-modifying antirheumatic drug therapy study
    • Genovese, M.C., McKay, J.D., Nasonov, E.L., Mysler, E.F., da Silva, N.A., Alecock, E., et al. Interleukin-6 receptor inhibition with tocilizumab reduces disease activity in rheumatoid arthritis with inadequate response to disease-modifying antirheumatic drugs: the tocilizumab in combination with traditional disease-modifying antirheumatic drug therapy study. Arthritis Rheum 58 (2008), 2968–2980.
    • (2008) Arthritis Rheum , vol.58 , pp. 2968-2980
    • Genovese, M.C.1    McKay, J.D.2    Nasonov, E.L.3    Mysler, E.F.4    da Silva, N.A.5    Alecock, E.6
  • 9
    • 0023945481 scopus 로고
    • The American Rheumatism Association1987 revised criteria for the classification of rheumatoid arthritis
    • Arnett, F.C., Edworthy, S.M., Bloch, D.A., McShane, D.J., Fries, J.F., Cooper, N.S., et al. The American Rheumatism Association1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 31 (1988), 315–324.
    • (1988) Arthritis Rheum , vol.31 , pp. 315-324
    • Arnett, F.C.1    Edworthy, S.M.2    Bloch, D.A.3    McShane, D.J.4    Fries, J.F.5    Cooper, N.S.6
  • 10
    • 84947035553 scopus 로고    scopus 로고
    • 2014 update of the Consensus Statement of the Spanish Society of Rheumatology on the use of biological therapies in rheumatoid arthritis
    • Sanmarti, R., Garcia-Rodriguez, S., Alvaro-Gracia, J.M., Andreu, J.L., Balsa, A., Caliz, R., et al. 2014 update of the Consensus Statement of the Spanish Society of Rheumatology on the use of biological therapies in rheumatoid arthritis. Reumatol Clin 11 (2015), 279–294.
    • (2015) Reumatol Clin , vol.11 , pp. 279-294
    • Sanmarti, R.1    Garcia-Rodriguez, S.2    Alvaro-Gracia, J.M.3    Andreu, J.L.4    Balsa, A.5    Caliz, R.6
  • 11
    • 84893772728 scopus 로고    scopus 로고
    • EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2013 update
    • Smolen, J.S., Landewe, R., Breedveld, F.C., Buch, M., Burmester, G., Dougados, M., et al. EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2013 update. Ann Rheum Dis 73 (2014), 492–509.
    • (2014) Ann Rheum Dis , vol.73 , pp. 492-509
    • Smolen, J.S.1    Landewe, R.2    Breedveld, F.C.3    Buch, M.4    Burmester, G.5    Dougados, M.6
  • 12
    • 0030068817 scopus 로고    scopus 로고
    • Development and validation of the European League Against Rheumatism response criteria for rheumatoid arthritis. Comparison with the preliminary American College of Rheumatology and the World Health Organization/International League Against Rheumatism Criteria
    • van Gestel, A.M., Prevoo, M.L., van ’t Hof, M.A., van Rijswijk, M.H., van de Putte, L.B., van Riel, P.L., Development and validation of the European League Against Rheumatism response criteria for rheumatoid arthritis. Comparison with the preliminary American College of Rheumatology and the World Health Organization/International League Against Rheumatism Criteria. Arthritis Rheum 39 (1996), 34–40.
    • (1996) Arthritis Rheum , vol.39 , pp. 34-40
    • van Gestel, A.M.1    Prevoo, M.L.2    van ’t Hof, M.A.3    van Rijswijk, M.H.4    van de Putte, L.B.5    van Riel, P.L.6
  • 13
    • 11244356734 scopus 로고    scopus 로고
    • SPSS 13.s Statistical procedures companion
    • Prentice Hall, Inc New Jersey
    • Norusis, M., SPSS 13.s Statistical procedures companion. 2004, Prentice Hall, Inc, New Jersey.
    • (2004)
    • Norusis, M.1
  • 14
    • 84879952087 scopus 로고    scopus 로고
    • Serum interleukin 6 before and after therapy with tocilizumab is a principal biomarker in patients with rheumatoid arthritis
    • Shimamoto, K., Ito, T., Ozaki, Y., Amuro, H., Tanaka, A., Nishizawa, T., et al. Serum interleukin 6 before and after therapy with tocilizumab is a principal biomarker in patients with rheumatoid arthritis. J Rheumatol 40 (2013), 1074–1081.
    • (2013) J Rheumatol , vol.40 , pp. 1074-1081
    • Shimamoto, K.1    Ito, T.2    Ozaki, Y.3    Amuro, H.4    Tanaka, A.5    Nishizawa, T.6
  • 15
    • 84898003691 scopus 로고    scopus 로고
    • Baseline levels of soluble interleukin-6 receptor predict clinical remission in patients with rheumatoid arthritis treated with tocilizumab: implications for molecular targeted therapy
    • Nishina, N., Kikuchi, J., Hashizume, M., Yoshimoto, K., Kameda, H., Takeuchi, T., Baseline levels of soluble interleukin-6 receptor predict clinical remission in patients with rheumatoid arthritis treated with tocilizumab: implications for molecular targeted therapy. Ann Rheum Dis 73 (2014), 945–947.
    • (2014) Ann Rheum Dis , vol.73 , pp. 945-947
    • Nishina, N.1    Kikuchi, J.2    Hashizume, M.3    Yoshimoto, K.4    Kameda, H.5    Takeuchi, T.6
  • 16
    • 84928253270 scopus 로고    scopus 로고
    • Low baseline interleukin-17A levels are associated with better treatment response at 12 weeks to tocilizumab therapy in rheumatoid arthritis patients
    • Lee, S.J., Park, W., Park, S.H., Shim, S.C., Baek, H.J., Yoo, D.H., et al. Low baseline interleukin-17A levels are associated with better treatment response at 12 weeks to tocilizumab therapy in rheumatoid arthritis patients. J Immunol Res, 2015, 2015, 487230.
    • (2015) J Immunol Res , vol.2015 , pp. 487230
    • Lee, S.J.1    Park, W.2    Park, S.H.3    Shim, S.C.4    Baek, H.J.5    Yoo, D.H.6
  • 17
    • 0026014522 scopus 로고
    • Correlation of serum interleukin-6 levels with joint involvement and thrombocytosis in systemic juvenile rheumatoid arthritis
    • de Benedetti, F., Massa, M., Robbioni, P., Ravelli, A., Burgio, G.R., Martini, A., Correlation of serum interleukin-6 levels with joint involvement and thrombocytosis in systemic juvenile rheumatoid arthritis. Arthritis Rheum 34 (1991), 1158–1163.
    • (1991) Arthritis Rheum , vol.34 , pp. 1158-1163
    • de Benedetti, F.1    Massa, M.2    Robbioni, P.3    Ravelli, A.4    Burgio, G.R.5    Martini, A.6
  • 18
    • 84885339903 scopus 로고    scopus 로고
    • IL-6 pathway-driven investigation of response to IL-6 receptor inhibition in rheumatoid arthritis
    • Wang, J., Platt, A., Upmanyu, R., Germer, S., Lei, G., Rabe, C., et al. IL-6 pathway-driven investigation of response to IL-6 receptor inhibition in rheumatoid arthritis. BMJ Open, 3, 2013, e003199.
    • (2013) BMJ Open , vol.3 , pp. e003199
    • Wang, J.1    Platt, A.2    Upmanyu, R.3    Germer, S.4    Lei, G.5    Rabe, C.6
  • 19
    • 79951942809 scopus 로고    scopus 로고
    • Humanized anti-interleukin-6-receptor antibody (tocilizumab) monotherapy is more effective in slowing radiographic progression in patients with rheumatoid arthritis at high baseline risk for structural damage evaluated with levels of biomarkers, radiography, and BMI: data from the SAMURAI study
    • Hashimoto, J., Garnero, P., van der Heijde, D., Miyasaka, N., Yamamoto, K., Kawai, S., et al. Humanized anti-interleukin-6-receptor antibody (tocilizumab) monotherapy is more effective in slowing radiographic progression in patients with rheumatoid arthritis at high baseline risk for structural damage evaluated with levels of biomarkers, radiography, and BMI: data from the SAMURAI study. Mod Rheumatol 21 (2011), 10–15.
    • (2011) Mod Rheumatol , vol.21 , pp. 10-15
    • Hashimoto, J.1    Garnero, P.2    van der Heijde, D.3    Miyasaka, N.4    Yamamoto, K.5    Kawai, S.6
  • 20
    • 84897569032 scopus 로고    scopus 로고
    • Drug free REmission/low disease activity after cessation of tocilizumab (Actemra) Monotherapy (DREAM) study
    • Nishimoto, N., Amano, K., Hirabayashi, Y., Horiuchi, T., Ishii, T., Iwahashi, M., et al. Drug free REmission/low disease activity after cessation of tocilizumab (Actemra) Monotherapy (DREAM) study. Mod Rheumatol 24 (2014), 17–25.
    • (2014) Mod Rheumatol , vol.24 , pp. 17-25
    • Nishimoto, N.1    Amano, K.2    Hirabayashi, Y.3    Horiuchi, T.4    Ishii, T.5    Iwahashi, M.6
  • 21
    • 0029863504 scopus 로고    scopus 로고
    • The function of the soluble interleukin 6 (IL-6) receptor in vivo: sensitization of human soluble IL-6 receptor transgenic mice towards IL-6 and prolongation of the plasma half-life of IL-6
    • Peters, M., Jacobs, S., Ehlers, M., Vollmer, P., Mullberg, J., Wolf, E., et al. The function of the soluble interleukin 6 (IL-6) receptor in vivo: sensitization of human soluble IL-6 receptor transgenic mice towards IL-6 and prolongation of the plasma half-life of IL-6. J Exp Med 183 (1996), 1399–1406.
    • (1996) J Exp Med , vol.183 , pp. 1399-1406
    • Peters, M.1    Jacobs, S.2    Ehlers, M.3    Vollmer, P.4    Mullberg, J.5    Wolf, E.6
  • 23
    • 84959552894 scopus 로고    scopus 로고
    • Predictive factors for induction of remission in patients with active rheumatoid arthritis treated with tocilizumab in clinical practice
    • Narvaez, J., Magallares, B., Diaz Torne, C., Hernandez, M.V., Reina, D., Corominas, H., et al. Predictive factors for induction of remission in patients with active rheumatoid arthritis treated with tocilizumab in clinical practice. Semin Arthritis Rheum 45 (2016), 386–390.
    • (2016) Semin Arthritis Rheum , vol.45 , pp. 386-390
    • Narvaez, J.1    Magallares, B.2    Diaz Torne, C.3    Hernandez, M.V.4    Reina, D.5    Corominas, H.6
  • 24
    • 58149154996 scopus 로고    scopus 로고
    • Mechanisms and pathologic significances in increase in serum interleukin-6 (IL-6) and soluble IL-6 receptor after administration of an anti-IL-6 receptor antibody, tocilizumab, in patients with rheumatoid arthritis and Castleman disease
    • Nishimoto, N., Terao, K., Mima, T., Nakahara, H., Takagi, N., Kakehi, T., Mechanisms and pathologic significances in increase in serum interleukin-6 (IL-6) and soluble IL-6 receptor after administration of an anti-IL-6 receptor antibody, tocilizumab, in patients with rheumatoid arthritis and Castleman disease. Blood 112 (2008), 3959–3964.
    • (2008) Blood , vol.112 , pp. 3959-3964
    • Nishimoto, N.1    Terao, K.2    Mima, T.3    Nakahara, H.4    Takagi, N.5    Kakehi, T.6
  • 25
    • 0028345082 scopus 로고
    • Serum soluble interleukin 6 (IL-6) receptor and IL-6/soluble IL-6 receptor complex in systemic juvenile rheumatoid arthritis
    • De Benedetti, F., Massa, M., Pignatti, P., Albani, S., Novick, D., Martini, A., Serum soluble interleukin 6 (IL-6) receptor and IL-6/soluble IL-6 receptor complex in systemic juvenile rheumatoid arthritis. J Clin Invest 93 (1994), 2114–2119.
    • (1994) J Clin Invest , vol.93 , pp. 2114-2119
    • De Benedetti, F.1    Massa, M.2    Pignatti, P.3    Albani, S.4    Novick, D.5    Martini, A.6
  • 26
    • 0026828552 scopus 로고
    • Isolation of an mRNA encoding a soluble form of the human interleukin-6 receptor
    • Lust, J.A., Donovan, K.A., Kline, M.P., Greipp, P.R., Kyle, R.A., Maihle, N.J., Isolation of an mRNA encoding a soluble form of the human interleukin-6 receptor. Cytokine 4 (1992), 96–100.
    • (1992) Cytokine , vol.4 , pp. 96-100
    • Lust, J.A.1    Donovan, K.A.2    Kline, M.P.3    Greipp, P.R.4    Kyle, R.A.5    Maihle, N.J.6
  • 28
    • 0028900662 scopus 로고
    • Pharmacokinetic study of anti-interleukin-6 (IL-6) therapy with monoclonal antibodies: enhancement of IL-6 clearance by cocktails of anti-IL-6 antibodies
    • Montero-Julian, F.A., Klein, B., Gautherot, E., Brailly, H., Pharmacokinetic study of anti-interleukin-6 (IL-6) therapy with monoclonal antibodies: enhancement of IL-6 clearance by cocktails of anti-IL-6 antibodies. Blood 85 (1995), 917–924.
    • (1995) Blood , vol.85 , pp. 917-924
    • Montero-Julian, F.A.1    Klein, B.2    Gautherot, E.3    Brailly, H.4
  • 29
    • 34548856204 scopus 로고    scopus 로고
    • Apoptosis is a natural stimulus of IL6R shedding and contributes to the proinflammatory trans-signaling function of neutrophils
    • Chalaris, A., Rabe, B., Paliga, K., Lange, H., Laskay, T., Fielding, C.A., et al. Apoptosis is a natural stimulus of IL6R shedding and contributes to the proinflammatory trans-signaling function of neutrophils. Blood 110 (2007), 1748–1755.
    • (2007) Blood , vol.110 , pp. 1748-1755
    • Chalaris, A.1    Rabe, B.2    Paliga, K.3    Lange, H.4    Laskay, T.5    Fielding, C.A.6
  • 30
    • 0035164602 scopus 로고    scopus 로고
    • The soluble interleukin 6 receptor: mechanisms of production and implications in disease
    • Jones, S.A., Horiuchi, S., Topley, N., Yamamoto, N., Fuller, G.M., The soluble interleukin 6 receptor: mechanisms of production and implications in disease. FASEB J 15 (2001), 43–58.
    • (2001) FASEB J , vol.15 , pp. 43-58
    • Jones, S.A.1    Horiuchi, S.2    Topley, N.3    Yamamoto, N.4    Fuller, G.M.5
  • 31
    • 0026557837 scopus 로고
    • Up-regulation of interleukin (IL)-6 receptor gene expression in vitro and in vivo in IL-6 deprived myeloma cells
    • Portier, M., Lees, D., Caron, E., Jourdan, M., Boiron, J.M., Bataille, R., et al. Up-regulation of interleukin (IL)-6 receptor gene expression in vitro and in vivo in IL-6 deprived myeloma cells. FEBS Lett 302 (1992), 35–38.
    • (1992) FEBS Lett , vol.302 , pp. 35-38
    • Portier, M.1    Lees, D.2    Caron, E.3    Jourdan, M.4    Boiron, J.M.5    Bataille, R.6
  • 32
    • 84885187505 scopus 로고    scopus 로고
    • Monitoring C-reactive protein levels to predict favourable clinical outcomes from tocilizumab treatment in patients with rheumatoid arthritis
    • Kojima, T., Yabe, Y., Kaneko, A., Hirano, Y., Ishikawa, H., Hayashi, M., et al. Monitoring C-reactive protein levels to predict favourable clinical outcomes from tocilizumab treatment in patients with rheumatoid arthritis. Mod Rheumatol 23 (2013), 977–985.
    • (2013) Mod Rheumatol , vol.23 , pp. 977-985
    • Kojima, T.1    Yabe, Y.2    Kaneko, A.3    Hirano, Y.4    Ishikawa, H.5    Hayashi, M.6
  • 33
    • 84978951824 scopus 로고    scopus 로고
    • Serum tocilizumab trough concentration can be used to monitor systemic IL-6 receptor blockade in patients with rheumatoid arthritis: a prospective observational cohort study
    • Kneepkens, E.L., van den Oever, I., Plasencia, C.H., Pascual-Salcedo, D., de Vries, A., Hart, M., et al. Serum tocilizumab trough concentration can be used to monitor systemic IL-6 receptor blockade in patients with rheumatoid arthritis: a prospective observational cohort study. Scand J Rheumatol 46 (2017), 87–94.
    • (2017) Scand J Rheumatol , vol.46 , pp. 87-94
    • Kneepkens, E.L.1    van den Oever, I.2    Plasencia, C.H.3    Pascual-Salcedo, D.4    de Vries, A.5    Hart, M.6
  • 34
    • 67650924512 scopus 로고    scopus 로고
    • Treatment-induced stable, moderate reduction in blood cell counts correlate to disease control in early rheumatoid arthritis
    • Lester, S.E., Proudman, S.M., Lee, A.T., Hall, C.A., McWilliams, L., James, M.J., et al. Treatment-induced stable, moderate reduction in blood cell counts correlate to disease control in early rheumatoid arthritis. Intern Med J 39 (2009), 296–303.
    • (2009) Intern Med J , vol.39 , pp. 296-303
    • Lester, S.E.1    Proudman, S.M.2    Lee, A.T.3    Hall, C.A.4    McWilliams, L.5    James, M.J.6
  • 35
    • 84861479861 scopus 로고    scopus 로고
    • Linking interleukin-6 receptor blockade with tocilizumab and its hematological effects using a modeling approach
    • Gibiansky, L., Frey, N., Linking interleukin-6 receptor blockade with tocilizumab and its hematological effects using a modeling approach. J Pharmacokinet Pharmacodyn 39 (2012), 5–16.
    • (2012) J Pharmacokinet Pharmacodyn , vol.39 , pp. 5-16
    • Gibiansky, L.1    Frey, N.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.