-
1
-
-
84879551222
-
Overview of epidemiology, pathophysiology, and diagnosis of rheumatoid arthritis
-
Gibofsky A. Overview of epidemiology, pathophysiology, and diagnosis of rheumatoid arthritis. Am J Manag Care 2012;18:S295-302.
-
(2012)
Am J Manag Care
, vol.18
, pp. S295-S302
-
-
Gibofsky, A.1
-
2
-
-
84956767541
-
American College of Rheumatology guideline for the treatment of rheumatoid arthritis
-
2015
-
Singh JA, Saag KG, Bridges SL Jr et al. 2015 American College of Rheumatology guideline for the treatment of rheumatoid arthritis. Arthritis Rheumatol 2016;68:1-26.
-
(2016)
Arthritis Rheumatol
, vol.68
, pp. 1-26
-
-
Singh, J.A.1
Saag, K.G.2
Bridges, S.L.3
-
3
-
-
77649194159
-
Excess mortality emerges after 10 years in an inception cohort of early rheumatoid arthritis
-
Radovits BJ, Fransen J, Al Shamma S et al. Excess mortality emerges after 10 years in an inception cohort of early rheumatoid arthritis. Arthritis Care Res 2010;62:362-70.
-
(2010)
Arthritis Care Res
, vol.62
, pp. 362-370
-
-
Radovits, B.J.1
Fransen, J.2
Al Shamma, S.3
-
4
-
-
84889632869
-
Prevalence of comorbidities in rheumatoid arthritis and evaluation of their monitoring: Results of an international, cross-sectional study (COMORA)
-
Dougados M, Soubrier M, Antunez A et al. Prevalence of comorbidities in rheumatoid arthritis and evaluation of their monitoring: results of an international, cross-sectional study (COMORA). Ann Rheum Dis 2014;73:62-8.
-
(2014)
Ann Rheum Dis
, vol.73
, pp. 62-68
-
-
Dougados, M.1
Soubrier, M.2
Antunez, A.3
-
5
-
-
84978063124
-
Affective disturbance in rheumatoid arthritis: Psychological and disease-related pathways
-
Sturgeon JA, Finan PH, Zautra AJ. Affective disturbance in rheumatoid arthritis: psychological and disease-related pathways. Nat Rev Rheumatol 2016;12:532-42.
-
(2016)
Nat Rev Rheumatol
, vol.12
, pp. 532-542
-
-
Sturgeon, J.A.1
Finan, P.H.2
Zautra, A.J.3
-
6
-
-
84988250032
-
Self-reported fatigue in rheumatoid arthritis. A pilot study
-
Tack BB. Self-reported fatigue in rheumatoid arthritis. A pilot study. Arthritis Care Res 1990;3:154-7.
-
(1990)
Arthritis Care Res
, vol.3
, pp. 154-157
-
-
Tack, B.B.1
-
7
-
-
4043152725
-
Impact of fatigue on health-related quality of life in rheumatoid arthritis
-
Rupp I, Boshuizen HC, Jacobi CE, Dinant HJ, van den Bos GA. Impact of fatigue on health-related quality of life in rheumatoid arthritis. Arthritis Rheum 2004;51:578-85.
-
(2004)
Arthritis Rheum
, vol.51
, pp. 578-585
-
-
Rupp, I.1
Boshuizen, H.C.2
Jacobi, C.E.3
Dinant, H.J.4
van den Bos, G.A.5
-
8
-
-
68149182498
-
Depression, inflammation, and pain in patients with rheumatoid arthritis
-
Kojima M, Kojima T, Suzuki S et al. Depression, inflammation, and pain in patients with rheumatoid arthritis. Arthritis Rheum 2009;61:1018-24.
-
(2009)
Arthritis Rheum
, vol.61
, pp. 1018-1024
-
-
Kojima, M.1
Kojima, T.2
Suzuki, S.3
-
9
-
-
49249095916
-
Comorbid depression in rheumatoid arthritis: Pathophysiology and clinical implications
-
Bruce TO. Comorbid depression in rheumatoid arthritis: pathophysiology and clinical implications. Curr Psychiatry Rep 2008;10:258-64.
-
(2008)
Curr Psychiatry Rep
, vol.10
, pp. 258-264
-
-
Bruce, T.O.1
-
10
-
-
85018193398
-
Patient-reported outcomes as end points in clinical trials in rheumatoid arthritis
-
Gossec L, Dougados M, Dixon W. Patient-reported outcomes as end points in clinical trials in rheumatoid arthritis. RMD Open 2015;1:e000019.
-
(2015)
RMD Open
, vol.1
, pp. e000019
-
-
Gossec, L.1
Dougados, M.2
Dixon, W.3
-
11
-
-
84927613610
-
Patient reported outcomes in rheumatoid arthritis clinical trials
-
Orbai A-M, Bingham CO III. Patient reported outcomes in rheumatoid arthritis clinical trials. Curr Rheumatol Rep 2015;17:28.
-
(2015)
Curr Rheumatol Rep
, vol.17
, pp. 28
-
-
Orbai, A.-M.1
Bingham, C.O.2
-
12
-
-
84863861008
-
Understanding the dynamics: Pathways involved in the pathogenesis of rheumatoid arthritis
-
Choy E. Understanding the dynamics: pathways involved in the pathogenesis of rheumatoid arthritis. Rheumatology 2012;51:v3-11.
-
(2012)
Rheumatology
, vol.51
, pp. v3-v11
-
-
Choy, E.1
-
13
-
-
84864106582
-
Role of interleukin-6 in stress, sleep, and fatigue
-
Rohleder N, Aringer M, Boentert M. Role of interleukin-6 in stress, sleep, and fatigue. Ann N Y Acad Sci 2012;1261:88-96.
-
(2012)
Ann N Y Acad Sci
, vol.1261
, pp. 88-96
-
-
Rohleder, N.1
Aringer, M.2
Boentert, M.3
-
14
-
-
84928568835
-
IL-6 as a keystone cytokine in health and disease
-
Hunter CA, Jones SA. IL-6 as a keystone cytokine in health and disease. Nat Immunol 2015;16:448-57.
-
(2015)
Nat Immunol
, vol.16
, pp. 448-457
-
-
Hunter, C.A.1
Jones, S.A.2
-
15
-
-
84869797922
-
IL-6 trans-signaling via the soluble IL-6 receptor: Importance for the pro-inflammatory activities of IL-6
-
Rose-John S. IL-6 trans-signaling via the soluble IL-6 receptor: importance for the pro-inflammatory activities of IL-6. Int J Biol Sci 2012;8:1237-47.
-
(2012)
Int J Biol Sci
, vol.8
, pp. 1237-1247
-
-
Rose-John, S.1
-
16
-
-
0027291691
-
Involvement of IL-6 signal transducer gp130 in IL-11-mediated signal transduction
-
Yin T, Taga T, Tsang ML et al. Involvement of IL-6 signal transducer gp130 in IL-11-mediated signal transduction. J Immunol 1993;151:2555-61.
-
(1993)
J Immunol
, vol.151
, pp. 2555-2561
-
-
Yin, T.1
Taga, T.2
Tsang, M.L.3
-
17
-
-
0023685762
-
Cloning and expression of the human interleukin-6 (BSF-2/IFN beta 2) receptor
-
Yamasaki K, Taga T, Hirata Y et al. Cloning and expression of the human interleukin-6 (BSF-2/IFN beta 2) receptor. Science 1988;241:825-8.
-
(1988)
Science
, vol.241
, pp. 825-828
-
-
Yamasaki, K.1
Taga, T.2
Hirata, Y.3
-
18
-
-
0028209870
-
Activation of JAK2 kinase mediated by the interleukin 6 signal transducer gp130
-
Narazaki M, Witthuhn BA, Yoshida K et al. Activation of JAK2 kinase mediated by the interleukin 6 signal transducer gp130. Proc Natl Acad Sci USA 1994;91:2285-9.
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 2285-2289
-
-
Narazaki, M.1
Witthuhn, B.A.2
Yoshida, K.3
-
20
-
-
84920285641
-
IL-6 biology: Implications for clinical targeting in rheumatic disease
-
Calabrese LH, Rose-John S. IL-6 biology: implications for clinical targeting in rheumatic disease. Nat Rev Rheumatol 2014;10:720-7.
-
(2014)
Nat Rev Rheumatol
, vol.10
, pp. 720-727
-
-
Calabrese, L.H.1
Rose-John, S.2
-
21
-
-
0028349735
-
Stat3: A STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6
-
Zhong Z, Wen Z, Darnell JE Jr. Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6. Science 1994;264:95-8.
-
(1994)
Science
, vol.264
, pp. 95-98
-
-
Zhong, Z.1
Wen, Z.2
Darnell, J.E.3
-
22
-
-
84896488117
-
Interleukin-6: From basic biology to selective blockade of pro-inflammatory activities
-
Scheller J, Garbers C, Rose-John S. Interleukin-6: from basic biology to selective blockade of pro-inflammatory activities. Semin Immunol 2014;26:2-12.
-
(2014)
Semin Immunol
, vol.26
, pp. 2-12
-
-
Scheller, J.1
Garbers, C.2
Rose-John, S.3
-
23
-
-
0036233585
-
Cytokine signaling in 2002: New surprises in the Jak/Stat pathway
-
O’Shea JJ, Gadina M, Schreiber RD. Cytokine signaling in 2002: new surprises in the Jak/Stat pathway. Cell 2002;109(Suppl):S121-31.
-
(2002)
Cell
, vol.109
, pp. S121-S131
-
-
O’Shea, J.J.1
Gadina, M.2
Schreiber, R.D.3
-
24
-
-
0032539893
-
Sympathetic neurons can produce and respond to interleukin 6
-
März P, Cheng J-G, Gadient RA et al. Sympathetic neurons can produce and respond to interleukin 6. Proc Natl Acad Sci USA 1998;95:3251-6.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 3251-3256
-
-
März, P.1
Cheng, J.-G.2
Gadient, R.A.3
-
25
-
-
0035160256
-
Soluble gp130 is the natural inhibitor of soluble interleukin-6 receptor transsignaling responses
-
Jostock T, Müllberg JG, Özbek S et al. Soluble gp130 is the natural inhibitor of soluble interleukin-6 receptor transsignaling responses. Eur J Biochem 2001;268:160-7.
-
(2001)
Eur J Biochem
, vol.268
, pp. 160-167
-
-
Jostock, T.1
Müllberg, J.G.2
Özbek, S.3
-
26
-
-
84555205600
-
IL-6/IL-6 receptor system and its role in physiological and pathological conditions
-
Mihara M, Hashizume M, Yoshida H, Suzuki M, Shiina M. IL-6/IL-6 receptor system and its role in physiological and pathological conditions. Clin Sci 2012;122:143-59.
-
(2012)
Clin Sci
, vol.122
, pp. 143-159
-
-
Mihara, M.1
Hashizume, M.2
Yoshida, H.3
Suzuki, M.4
Shiina, M.5
-
27
-
-
24944522529
-
Hypothalamic-pituitary-adrenal axis activity in patients with rheumatoid arthritis
-
Eijsbouts AM, van den Hoogen FH, Laan RF et al. Hypothalamic-pituitary-adrenal axis activity in patients with rheumatoid arthritis. Clin Exp Rheumatol 2005;23:658-64.
-
(2005)
Clin Exp Rheumatol
, vol.23
, pp. 658-664
-
-
Eijsbouts, A.M.1
van den Hoogen, F.H.2
Laan, R.F.3
-
28
-
-
84880395973
-
Fatigue in rheumatoid arthritis and its relation to interleukin-6 serum level
-
Helal AM, Shahine EM, Hassan MM, Hashad DI, Moneim RA. Fatigue in rheumatoid arthritis and its relation to interleukin-6 serum level. Egypt Rheumatol 2012;34:153-7.
-
(2012)
Egypt Rheumatol
, vol.34
, pp. 153-157
-
-
Helal, A.M.1
Shahine, E.M.2
Hassan, M.M.3
Hashad, D.I.4
Moneim, R.A.5
-
29
-
-
84920850506
-
Nociceptive neurons detect cytokines in arthritis
-
Schaible H-G. Nociceptive neurons detect cytokines in arthritis. Arthritis Res Ther 2014;16:470.
-
(2014)
Arthritis Res Ther
, vol.16
, pp. 470
-
-
Schaible, H.-G.1
-
30
-
-
0032826994
-
Neural activities of IL-6-type cytokines often depend on soluble cytokine receptors
-
März P, Otten U, Rose-John S. Neural activities of IL-6-type cytokines often depend on soluble cytokine receptors. Eur J Neurosci 1999;11:2995-3004.
-
(1999)
Eur J Neurosci
, vol.11
, pp. 2995-3004
-
-
März, P.1
Otten, U.2
Rose-John, S.3
-
31
-
-
84870439250
-
Effect and treatment of chronic pain in inflammatory arthritis
-
Lee YC. Effect and treatment of chronic pain in inflammatory arthritis. Curr Rheumatol Rep 2013;15:300.
-
(2013)
Curr Rheumatol Rep
, vol.15
, pp. 300
-
-
Lee, Y.C.1
-
32
-
-
13244290236
-
Seven year changes in health status and priorities for improvement of health in patients with rheumatoid arthritis
-
Heiberg T, Finset A, Uhlig T, Kvien TK. Seven year changes in health status and priorities for improvement of health in patients with rheumatoid arthritis. Ann Rheum Dis 2005;64:191-5.
-
(2005)
Ann Rheum Dis
, vol.64
, pp. 191-195
-
-
Heiberg, T.1
Finset, A.2
Uhlig, T.3
Kvien, T.K.4
-
33
-
-
0034833986
-
Predictors of radiographic joint damage in patients with early rheumatoid arthritis
-
Jansen LM, van der Horst-Bruinsma IE, van Schaardenburg D, Bezemer PD, Dijkmans BA. Predictors of radiographic joint damage in patients with early rheumatoid arthritis. Ann Rheum Dis 2001;60:924-7.
-
(2001)
Ann Rheum Dis
, vol.60
, pp. 924-927
-
-
Jansen, L.M.1
van der Horst-Bruinsma, I.E.2
van Schaardenburg, D.3
Bezemer, P.D.4
Dijkmans, B.A.5
-
34
-
-
84945463043
-
A mechanism-based approach to the management of osteoarthritis pain
-
Cohen E, Lee YC. A mechanism-based approach to the management of osteoarthritis pain. Curr Osteoporos Rep 2015;13:399-406.
-
(2015)
Curr Osteoporos Rep
, vol.13
, pp. 399-406
-
-
Cohen, E.1
Lee, Y.C.2
-
35
-
-
84974622435
-
Interleukin-6: An emerging regulator of pathological pain
-
Zhou Y-Q, Liu Z, Liu Z-H et al. Interleukin-6: an emerging regulator of pathological pain. J Neuroinflammation 2016;13:141.
-
(2016)
J Neuroinflammation
, vol.13
, pp. 141
-
-
Zhou, Y.-Q.1
Liu, Z.2
Liu, Z.-H.3
-
36
-
-
21344458574
-
Acute and long-term effects of IL-6 on cultured dorsal root ganglion neurones from adult rat
-
von Banchet GS, Kiehl M, Schaible H-G. Acute and long-term effects of IL-6 on cultured dorsal root ganglion neurones from adult rat. J Neurochem 2005;94:238-48.
-
(2005)
J Neurochem
, vol.94
, pp. 238-248
-
-
von Banchet, G.S.1
Kiehl, M.2
Schaible, H.-G.3
-
37
-
-
21944443712
-
Fast modulation of heat-activated ionic current by proinflammatory interleukin 6 in rat sensory neurons
-
Obreja O, Biasio W, Andratsch M et al. Fast modulation of heat-activated ionic current by proinflammatory interleukin 6 in rat sensory neurons. Brain 2005;128:1634-41.
-
(2005)
Brain
, vol.128
, pp. 1634-1641
-
-
Obreja, O.1
Biasio, W.2
Andratsch, M.3
-
38
-
-
80053345981
-
Genetic evidence for an essential role of neuronally expressed IL-6 signal transducer gp130 in the induction and maintenance of experimentally induced mechanical hypersensitivity in vivo and in vitro
-
Quarta S, Vogl C, Constantin CE et al. Genetic evidence for an essential role of neuronally expressed IL-6 signal transducer gp130 in the induction and maintenance of experimentally induced mechanical hypersensitivity in vivo and in vitro. Mol Pain 2011;7:73.
-
(2011)
Mol Pain
, vol.7
, pp. 73
-
-
Quarta, S.1
Vogl, C.2
Constantin, C.E.3
-
39
-
-
33846218186
-
Sensitization of unmyelinated sensory fibers of the joint nerve to mechanical stimuli by interleukin-6 in the rat: An inflammatory mechanism of joint pain
-
Brenn D, Richter F, Schaible H-G. Sensitization of unmyelinated sensory fibers of the joint nerve to mechanical stimuli by interleukin-6 in the rat: an inflammatory mechanism of joint pain. Arthritis Rheum 2007;56:351-9.
-
(2007)
Arthritis Rheum
, vol.56
, pp. 351-359
-
-
Brenn, D.1
Richter, F.2
Schaible, H.-G.3
-
40
-
-
77954411511
-
Differential effects of locally and systemically administered soluble glycoprotein 130 on pain and inflammation in experimental arthritis
-
Boettger MK, Leuchtweis J, Kümmel D et al. Differential effects of locally and systemically administered soluble glycoprotein 130 on pain and inflammation in experimental arthritis. Arthritis Res Ther 2010;12:R140.
-
(2010)
Arthritis Res Ther
, vol.12
, pp. R140
-
-
Boettger, M.K.1
Leuchtweis, J.2
Kümmel, D.3
-
41
-
-
70350555279
-
A key role for gp130 expressed on peripheral sensory nerves in pathological pain
-
Andratsch M, Mair N, Constantin CE et al. A key role for gp130 expressed on peripheral sensory nerves in pathological pain. J Neurosci 2009;29:13473-83.
-
(2009)
J Neurosci
, vol.29
, pp. 13473-13483
-
-
Andratsch, M.1
Mair, N.2
Constantin, C.E.3
-
42
-
-
84863197708
-
Spinal interleukin-6 is an amplifier of arthritic pain in the rat
-
Vazquez E, Kahlenbach J, Segond von Banchet G et al. Spinal interleukin-6 is an amplifier of arthritic pain in the rat. Arthritis Rheum 2012;64:2233-42.
-
(2012)
Arthritis Rheum
, vol.64
, pp. 2233-2242
-
-
Vazquez, E.1
Kahlenbach, J.2
Segond von Banchet, G.3
-
43
-
-
84929881847
-
Sarilumab plus methotrexate in patients with active rheumatoid arthritis and inadequate response to methotrexate: Results of a phase III study
-
Genovese MC, Fleischmann R, Kivitz AJ et al. Sarilumab plus methotrexate in patients with active rheumatoid arthritis and inadequate response to methotrexate: results of a phase III study. Arthritis. Rheumatol 2015;67:1424-37.
-
(2015)
Arthritis. Rheumatol
, vol.67
, pp. 1424-1437
-
-
Genovese, M.C.1
Fleischmann, R.2
Kivitz, A.J.3
-
44
-
-
85048798177
-
-
South San Francisco, CA: Genentech
-
Actemra [package insert]. South San Francisco, CA: Genentech, 2016.
-
(2016)
Actemra [Package Insert]
-
-
-
45
-
-
84989159523
-
Spotlight on sirukumab for the treatment of rheumatoid arthritis: The evidence to date
-
Lazzerini PE, Capecchi PL, Guidelli GM et al. Spotlight on sirukumab for the treatment of rheumatoid arthritis: the evidence to date. Drug Des Devel Ther 2016;10:3083-98.
-
(2016)
Drug Des Devel Ther
, vol.10
, pp. 3083-3098
-
-
Lazzerini, P.E.1
Capecchi, P.L.2
Guidelli, G.M.3
-
46
-
-
80755127065
-
Measures of adult pain: Visual Analog Scale for Pain (VAS Pain), Numeric Rating Scale for Pain (NRS Pain), McGill Pain Questionnaire (MPQ), Short-Form McGill Pain Questionnaire (SF-MPQ), Chronic Pain Grade Scale (CPGS), Short Form-36 Bodily Pain Scale (SF-36 BPS), and Measure of Intermittent and Constant Osteoarthritis Pain (ICOAP)
-
Hawker GA, Mian S, Kendzerska T, French M. Measures of adult pain: Visual Analog Scale for Pain (VAS Pain), Numeric Rating Scale for Pain (NRS Pain), McGill Pain Questionnaire (MPQ), Short-Form McGill Pain Questionnaire (SF-MPQ), Chronic Pain Grade Scale (CPGS), Short Form-36 Bodily Pain Scale (SF-36 BPS), and Measure of Intermittent and Constant Osteoarthritis Pain (ICOAP). Arthritis Care Res (Hoboken) 2011;63:S240-52.
-
(2011)
Arthritis Care Res (Hoboken)
, vol.63
, pp. S240-S252
-
-
Hawker, G.A.1
Mian, S.2
Kendzerska, T.3
French, M.4
-
47
-
-
40749114497
-
Effect of interleukin-6 receptor inhibition with tocilizumab in patients with rheumatoid arthritis (OPTION study): A double-blind, placebo-controlled, randomised trial
-
Smolen JS, Beaulieu A, Rubbert-Roth A et al. Effect of interleukin-6 receptor inhibition with tocilizumab in patients with rheumatoid arthritis (OPTION study): a double-blind, placebo-controlled, randomised trial. Lancet 2008;371:987-97.
-
(2008)
Lancet
, vol.371
, pp. 987-997
-
-
Smolen, J.S.1
Beaulieu, A.2
Rubbert-Roth, A.3
-
48
-
-
79953680176
-
Tocilizumab inhibits structural joint damage in rheumatoid arthritis patients with inadequate responses to methotrexate: Results from the double-blind treatment phase of a randomized placebo-controlled trial of tocilizumab safety and prevention of structural joint damage at one year
-
Kremer JM, Blanco R, Brzosko M et al. Tocilizumab inhibits structural joint damage in rheumatoid arthritis patients with inadequate responses to methotrexate: results from the double-blind treatment phase of a randomized placebo-controlled trial of tocilizumab safety and prevention of structural joint damage at one year. Arthritis Rheum 2011;63:609-21.
-
(2011)
Arthritis Rheum
, vol.63
, pp. 609-621
-
-
Kremer, J.M.1
Blanco, R.2
Brzosko, M.3
-
49
-
-
84873600423
-
Tocilizumab inhibits structural joint damage and improves physical function in patients with rheumatoid arthritis and inadequate responses to methotrexate: LITHE study 2-year results
-
Fleischmann RM, Halland A-M, Brzosko M et al. Tocilizumab inhibits structural joint damage and improves physical function in patients with rheumatoid arthritis and inadequate responses to methotrexate: LITHE study 2-year results. J Rheumatol 2013;40:113-26.
-
(2013)
J Rheumatol
, vol.40
, pp. 113-126
-
-
Fleischmann, R.M.1
Halland, A.-M.2
Brzosko, M.3
-
50
-
-
79953319576
-
Effectiveness and safety of the interleukin 6-receptor antagonist tocilizumab after 4 and 24 weeks in patients with active rheumatoid arthritis: The first phase IIIb real-life study (TAMARA)
-
Burmester GR, Feist E, Kellner H et al. Effectiveness and safety of the interleukin 6-receptor antagonist tocilizumab after 4 and 24 weeks in patients with active rheumatoid arthritis: the first phase IIIb real-life study (TAMARA). Ann Rheum Dis 2011;70:755-9.
-
(2011)
Ann Rheum Dis
, vol.70
, pp. 755-759
-
-
Burmester, G.R.1
Feist, E.2
Kellner, H.3
-
51
-
-
73449118587
-
Comparison of tocilizumab monotherapy versus methotrexate monotherapy in patients with moderate to severe rheumatoid arthritis: The AMBITION study
-
Jones G, Sebba A, Gu J et al. Comparison of tocilizumab monotherapy versus methotrexate monotherapy in patients with moderate to severe rheumatoid arthritis: the AMBITION study. Ann Rheum Dis 2010;69:88-96.
-
(2010)
Ann Rheum Dis
, vol.69
, pp. 88-96
-
-
Jones, G.1
Sebba, A.2
Gu, J.3
-
52
-
-
84985903427
-
Sarilumab plus methotrexate improves patient-reported outcomes in patients with active rheumatoid arthritis and inadequate responses to methotrexate: Results of a phase III trial
-
Strand V, Kosinski M, Chen C-I et al. Sarilumab plus methotrexate improves patient-reported outcomes in patients with active rheumatoid arthritis and inadequate responses to methotrexate: results of a phase III trial. Arthritis Res Ther 2016;18:198.
-
(2016)
Arthritis Res Ther
, vol.18
, pp. 198
-
-
Strand, V.1
Kosinski, M.2
Chen, C.-I.3
-
53
-
-
85035311704
-
Sarilumab improves patient-reported outcomes in rheumatoid arthritis patients with inadequate response/intolerance to tumour necrosis factor inhibitors
-
Strand V, Reaney M, Chen C-I et al. Sarilumab improves patient-reported outcomes in rheumatoid arthritis patients with inadequate response/intolerance to tumour necrosis factor inhibitors. RMD Open 2017;3:e000416.
-
(2017)
RMD Open
, vol.3
, pp. e000416
-
-
Strand, V.1
Reaney, M.2
Chen, C.-I.3
-
54
-
-
85019144284
-
Efficacy and safety of sarilumab monotherapy versus adalimumab monotherapy for the treatment of patients with active rheumatoid arthritis (MONARCH): A randomised, double-blind, parallel-group phase III trial
-
Burmester GR, Lin Y, Patel R et al. Efficacy and safety of sarilumab monotherapy versus adalimumab monotherapy for the treatment of patients with active rheumatoid arthritis (MONARCH): a randomised, double-blind, parallel-group phase III trial. Ann Rheum Dis 2017;76:840-7.
-
(2017)
Ann Rheum Dis
, vol.76
, pp. 840-847
-
-
Burmester, G.R.1
Lin, Y.2
Patel, R.3
-
55
-
-
85012898645
-
Efficacy and safety of sirukumab in patients with active rheumatoid arthritis refractory to anti-TNF therapy (SIRROUND-T): A randomised, double-blind, placebo-controlled, parallel-group, multinational, phase 3 study
-
Aletaha D, Bingham CO, III, Tanaka Y et al. Efficacy and safety of sirukumab in patients with active rheumatoid arthritis refractory to anti-TNF therapy (SIRROUND-T): a randomised, double-blind, placebo-controlled, parallel-group, multinational, phase 3 study. Lancet 2017;389:1206-17.
-
(2017)
Lancet
, vol.389
, pp. 1206-1217
-
-
Aletaha, D.1
Bingham, C.O.2
Tanaka, Y.3
-
56
-
-
26844489587
-
Patients’ perceptions of fatigue in rheumatoid arthritis: Overwhelming, uncontrollable, ignored
-
Hewlett S, Cockshott Z, Byron M et al. Patients’ perceptions of fatigue in rheumatoid arthritis: overwhelming, uncontrollable, ignored. Arthritis Rheum 2005;53:697-702.
-
(2005)
Arthritis Rheum
, vol.53
, pp. 697-702
-
-
Hewlett, S.1
Cockshott, Z.2
Byron, M.3
-
57
-
-
84866170613
-
The impact of tocilizumab on physical function and quality of life in patients with rheumatoid arthritis: A systematic literature review and interpretation
-
Townes SV, Furst DE, Thenkondar A. The impact of tocilizumab on physical function and quality of life in patients with rheumatoid arthritis: a systematic literature review and interpretation. Open Access Rheumatol 2012;4:87-92.
-
(2012)
Open Access Rheumatol
, vol.4
, pp. 87-92
-
-
Townes, S.V.1
Furst, D.E.2
Thenkondar, A.3
-
58
-
-
84879703022
-
Fatigue and factors related to fatigue in rheumatoid arthritis: A systematic review
-
Nikolaus S, Bode C, Taal E, van de Laar MA. Fatigue and factors related to fatigue in rheumatoid arthritis: a systematic review. Arthritis Care Res 2013;65:1128-46.
-
(2013)
Arthritis Care Res
, vol.65
, pp. 1128-1146
-
-
Nikolaus, S.1
Bode, C.2
Taal, E.3
van de Laar, M.A.4
-
59
-
-
0029037126
-
The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation
-
Chrousos GP. The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation. N Engl J Med 1995;332:1351-62.
-
(1995)
N Engl J Med
, vol.332
, pp. 1351-1362
-
-
Chrousos, G.P.1
-
60
-
-
17844373572
-
Immune modulation of the hypothalamic-pituitary-adrenal (HPA) axis during viral infection
-
Silverman MN, Pearce BD, Biron CA, Miller AH. Immune modulation of the hypothalamic-pituitary-adrenal (HPA) axis during viral infection. Viral Immunol 2005;18:41-78.
-
(2005)
Viral Immunol
, vol.18
, pp. 41-78
-
-
Silverman, M.N.1
Pearce, B.D.2
Biron, C.A.3
Miller, A.H.4
-
61
-
-
84864083173
-
Glucocorticoid regulation of inflammation and its functional correlates: From HPA axis to glucocorticoid receptor dysfunction
-
Silverman MN, Sternberg EM. Glucocorticoid regulation of inflammation and its functional correlates: from HPA axis to glucocorticoid receptor dysfunction. Ann N Y Acad Sci 2012;1261:55-63.
-
(2012)
Ann N Y Acad Sci
, vol.1261
, pp. 55-63
-
-
Silverman, M.N.1
Sternberg, E.M.2
-
62
-
-
84887820443
-
Hypothalamic-pituitary-adrenal axis dysfunction in chronic fatigue syndrome
-
Papadopoulos AS, Cleare AJ. Hypothalamic-pituitary-adrenal axis dysfunction in chronic fatigue syndrome. Nat Rev Endocrinol 2011;8:2232.
-
(2011)
Nat Rev Endocrinol
, vol.8
, pp. 2232
-
-
Papadopoulos, A.S.1
Cleare, A.J.2
-
63
-
-
84926611693
-
Is dysregulation of the HPA-axis a core pathophysiology mediating co-morbid depression in neurodegenerative diseases?
-
Du X, Pang TY. Is dysregulation of the HPA-axis a core pathophysiology mediating co-morbid depression in neurodegenerative diseases? Front Psychiatry 2015;6:32.
-
(2015)
Front Psychiatry
, vol.6
, pp. 32
-
-
Du, X.1
Pang, T.Y.2
-
64
-
-
0036805791
-
Hypothalamic-pituitary-adrenal axis, neuroendocrine factors and stress
-
Tsigos C, Chrousos GP. Hypothalamic-pituitary-adrenal axis, neuroendocrine factors and stress. J Psychosom Res 2002;53:865-71.
-
(2002)
J Psychosom Res
, vol.53
, pp. 865-871
-
-
Tsigos, C.1
Chrousos, G.P.2
-
65
-
-
0027131202
-
Recombinant interleukin-6 activates the hypothalamic-pituitary-adrenalaxis in humans
-
Mastorakos G, Chrousos GP, Weber JS. Recombinant interleukin-6 activates the hypothalamic-pituitary-adrenalaxis in humans. J Clin Endocrinol Metab 1993;77:1690-4.
-
(1993)
J Clin Endocrinol Metab
, vol.77
, pp. 1690-1694
-
-
Mastorakos, G.1
Chrousos, G.P.2
Weber, J.S.3
-
68
-
-
0031724942
-
Acute effects of recombinant human interleukin-6 on endocrine and central nervous sleep functions in healthy men
-
Späth-Schwalbe E, Hansen K, Schmidt F et al. Acute effects of recombinant human interleukin-6 on endocrine and central nervous sleep functions in healthy men. J Clin Endocrinol Metab 1998;83:1573-9.
-
(1998)
J Clin Endocrinol Metab
, vol.83
, pp. 1573-1579
-
-
Späth-Schwalbe, E.1
Hansen, K.2
Schmidt, F.3
-
70
-
-
0030936387
-
Circadian relationships between interleukin (IL)-6 and hypothalamic-pituitary-adrenal axis hormones: Failure of IL-6 to cause sustained hypercortisolism in patients with early untreated rheumatoid arthritis
-
Crofford LJ, Kalogeras KT, Mastorakos G et al. Circadian relationships between interleukin (IL)-6 and hypothalamic-pituitary-adrenal axis hormones: failure of IL-6 to cause sustained hypercortisolism in patients with early untreated rheumatoid arthritis. J Clin Endocrinol Metab 1997;82:1279-83.
-
(1997)
J Clin Endocrinol Metab
, vol.82
, pp. 1279-1283
-
-
Crofford, L.J.1
Kalogeras, K.T.2
Mastorakos, G.3
-
71
-
-
18744368778
-
Validation of the functional Assessment of Chronic Illness Therapy Fatigue Scale relative to other instrumentation in patients with rheumatoid arthritis
-
Cella D, Yount S, Sorensen M et al. Validation of the Functional Assessment of Chronic Illness Therapy Fatigue Scale relative to other instrumentation in patients with rheumatoid arthritis. J Rheumatol 2005;32:811-9.
-
(2005)
J Rheumatol
, vol.32
, pp. 811-819
-
-
Cella, D.1
Yount, S.2
Sorensen, M.3
-
72
-
-
84982106340
-
Biologic interventions for fatigue in rheumatoid arthritis
-
Almeida C, Choy EH, Hewlett S et al. Biologic interventions for fatigue in rheumatoid arthritis. Cochrane Database Syst Rev 2016;6;CD008334.
-
(2016)
Cochrane Database Syst Rev
, vol.6
, pp. CD008334
-
-
Almeida, C.1
Choy, E.H.2
Hewlett, S.3
-
73
-
-
84855381748
-
Sleep disturbances and interleukin 6 receptor inhibition in rheumatoid arthritis
-
Fragiadaki K, Tektonidou MG, Konsta M, Chrousos GP, Sfikakis PP. Sleep disturbances and interleukin 6 receptor inhibition in rheumatoid arthritis. J Rheumatol 2012;39:60-2.
-
(2012)
J Rheumatol
, vol.39
, pp. 60-62
-
-
Fragiadaki, K.1
Tektonidou, M.G.2
Konsta, M.3
Chrousos, G.P.4
Sfikakis, P.P.5
-
74
-
-
84877275257
-
Tocilizumab monotherapy versus adalimumab monotherapy for treatment of rheumatoid arthritis (ADACTA): A randomised, double-blind, controlled phase 4 trial
-
Gabay C, Emery P, van Vollenhoven R et al. Tocilizumab monotherapy versus adalimumab monotherapy for treatment of rheumatoid arthritis (ADACTA): a randomised, double-blind, controlled phase 4 trial. Lancet 2013;381:1541-50.
-
(2013)
Lancet
, vol.381
, pp. 1541-1550
-
-
Gabay, C.1
Emery, P.2
van Vollenhoven, R.3
-
75
-
-
84863464622
-
Anxiety and depression among US adults with arthritis: Prevalence and correlates
-
Murphy LB, Sacks JJ, Brady TJ, Hootman JM, Chapman DP. Anxiety and depression among US adults with arthritis: prevalence and correlates. Arthritis Care Res 2012;64:968-76.
-
(2012)
Arthritis Care Res
, vol.64
, pp. 968-976
-
-
Murphy, L.B.1
Sacks, J.J.2
Brady, T.J.3
Hootman, J.M.4
Chapman, D.P.5
-
76
-
-
84887659655
-
The prevalence of depression in rheumatoid arthritis: A systematic review and meta-analysis
-
Matcham F, Rayner L, Steer S, Hotopf M. The prevalence of depression in rheumatoid arthritis: a systematic review and meta-analysis. Rheumatology 2013;52:2136-48.
-
(2013)
Rheumatology
, vol.52
, pp. 2136-2148
-
-
Matcham, F.1
Rayner, L.2
Steer, S.3
Hotopf, M.4
-
77
-
-
84887338733
-
The temporal relationship between depression and rheumatoid arthritis disease activity, treatment persistence and response: A systematic review
-
Rathbun AM, Reed GW, Harrold LR. The temporal relationship between depression and rheumatoid arthritis disease activity, treatment persistence and response: a systematic review. Rheumatology 2013;52:1785-94.
-
(2013)
Rheumatology
, vol.52
, pp. 1785-1794
-
-
Rathbun, A.M.1
Reed, G.W.2
Harrold, L.R.3
-
78
-
-
84909595107
-
Individual differences in the peripheral immune system promote resilience versus susceptibility to social stress
-
Hodes GE, Pfau ML, Leboeuf M et al. Individual differences in the peripheral immune system promote resilience versus susceptibility to social stress. Proc Natl Acad Sci USA 2014;111:16136-41.
-
(2014)
Proc Natl Acad Sci USA
, vol.111
, pp. 16136-16141
-
-
Hodes, G.E.1
Pfau, M.L.2
Leboeuf, M.3
-
79
-
-
84930180545
-
Interleukin-6 as a predictor of symptom resolution in psychological distress: A cohort study
-
Virtanen M, Shipley MJ, Batty GD et al. Interleukin-6 as a predictor of symptom resolution in psychological distress: a cohort study. Psychol Med 2015;45:2137-44.
-
(2015)
Psychol Med
, vol.45
, pp. 2137-2144
-
-
Virtanen, M.1
Shipley, M.J.2
Batty, G.D.3
-
80
-
-
84940609837
-
Cumulative meta-analysis of interleukins 6 and 1β, tumour necrosis factor α and C-reactive protein in patients with major depressive disorder
-
Haapakoski R, Mathieu J, Ebmeier KP, Alenius H, Kivimäki M. Cumulative meta-analysis of interleukins 6 and 1β, tumour necrosis factor α and C-reactive protein in patients with major depressive disorder. Brain Behav Immun 2015;49:206-15.
-
(2015)
Brain Behav Immun
, vol.49
, pp. 206-215
-
-
Haapakoski, R.1
Mathieu, J.2
Ebmeier, K.P.3
Alenius, H.4
Kivimäki, M.5
-
82
-
-
0031282469
-
Increased serum IL-6 and IL-1 receptor antagonist concentrations in major depression and treatment resistant depression
-
Maes M, Bosmans E, De Jongh R et al. Increased serum IL-6 and IL-1 receptor antagonist concentrations in major depression and treatment resistant depression. Cytokine 1997;9:853-8.
-
(1997)
Cytokine
, vol.9
, pp. 853-858
-
-
Maes, M.1
Bosmans, E.2
De Jongh, R.3
-
83
-
-
84962037349
-
Integrating interleukin-6 into depression diagnosis and treatment
-
Hodes GE, Ménard C, Russo SJ. Integrating interleukin-6 into depression diagnosis and treatment. Neurobiol Stress 2016;4:15-22.
-
(2016)
Neurobiol Stress
, vol.4
, pp. 15-22
-
-
Hodes, G.E.1
Ménard, C.2
Russo, S.J.3
-
84
-
-
70449769018
-
Functional polymorphisms in the interleukin-6 and serotonin transporter genes, and depression and fatigue induced by interferon-α and ribavirin treatment
-
Bull SJ, Huezo-Diaz P, Binder EB et al. Functional polymorphisms in the interleukin-6 and serotonin transporter genes, and depression and fatigue induced by interferon-α and ribavirin treatment. Mol Psychiatry 2009;14:1095-104.
-
(2009)
Mol Psychiatry
, vol.14
, pp. 1095-1104
-
-
Bull, S.J.1
Huezo-Diaz, P.2
Binder, E.B.3
-
85
-
-
0035894157
-
Immunotherapy with interferon-alpha in patients affected by chronic hepatitis c induces an intercorrelated stimulation of the cytokine network and an increase in depressive and anxiety symptoms
-
Bonaccorso S, Puzella A, Marino V et al. Immunotherapy with interferon-alpha in patients affected by chronic hepatitis C induces an intercorrelated stimulation of the cytokine network and an increase in depressive and anxiety symptoms. Psychiatry Res 2001;105:45-55.
-
(2001)
Psychiatry Res
, vol.105
, pp. 45-55
-
-
Bonaccorso, S.1
Puzella, A.2
Marino, V.3
-
86
-
-
84877921458
-
Influence of hypothalamic IL-6/gp130 receptor signaling on the HPA axis response to chronic stress
-
Girotti M, Donegan JJ, Morilak DA. Influence of hypothalamic IL-6/gp130 receptor signaling on the HPA axis response to chronic stress. Psychoneuroendocrinology 2013;38:1158-69.
-
(2013)
Psychoneuroendocrinology
, vol.38
, pp. 1158-1169
-
-
Girotti, M.1
Donegan, J.J.2
Morilak, D.A.3
-
87
-
-
84969750167
-
Usefulness of the SF-36 health survey in screening for depressive and anxiety disorders in rheumatoid arthritis
-
Matcham F, Norton S, Steer S, Hotopf M. Usefulness of the SF-36 Health Survey in screening for depressive and anxiety disorders in rheumatoid arthritis. BMC Musculoskelet Disord 2016;17:224.
-
(2016)
BMC Musculoskelet Disord
, vol.17
, pp. 224
-
-
Matcham, F.1
Norton, S.2
Steer, S.3
Hotopf, M.4
-
88
-
-
84946486517
-
Fatigue in chronic inflammation - A link to pain pathways
-
Louati K, Berenbaum F. Fatigue in chronic inflammation - a link to pain pathways. Arthritis Res Ther 2015;17:254.
-
(2015)
Arthritis Res Ther
, vol.17
, pp. 254
-
-
Louati, K.1
Berenbaum, F.2
-
89
-
-
0034885297
-
Hypothalamic-pituitary-adrenal axis regulation of inflammation in rheumatoid arthritis
-
Morand EF, Leech M. Hypothalamic-pituitary-adrenal axis regulation of inflammation in rheumatoid arthritis. Immunol Cell Biol 2001;79:395-9.
-
(2001)
Immunol Cell Biol
, vol.79
, pp. 395-399
-
-
Morand, E.F.1
Leech, M.2
|