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Volumn 3, Issue 2, 2016, Pages 337-352

Incidence of Gastrointestinal Perforations in Patients with Rheumatoid Arthritis Treated with Tocilizumab from Clinical Trial, Postmarketing, and Real-World Data Sources

Author keywords

Gastrointestinal perforation; Rheumatoid arthritis; Tocilizumab

Indexed keywords


EID: 85034703112     PISSN: 21986576     EISSN: 21986584     Source Type: Journal    
DOI: 10.1007/s40744-016-0037-z     Document Type: Article
Times cited : (23)

References (23)
  • 1
    • 34848839947 scopus 로고    scopus 로고
    • Limited efficacy of conventional DMARDs after initial methotrexate failure in patients with recent onset rheumatoid arthritis treated according to the disease activity score
    • PID: 17293364
    • van der Kooij SM, de Vries-Bouwstra JK, Goekoop-Ruiterman YP, et al. Limited efficacy of conventional DMARDs after initial methotrexate failure in patients with recent onset rheumatoid arthritis treated according to the disease activity score. Ann Rheum Dis. 2007;66:1356–62. DOI: 10.1136/ard.2006.066662
    • (2007) Ann Rheum Dis , vol.66 , pp. 1356-1362
    • van der Kooij, S.M.1    de Vries-Bouwstra, J.K.2    Goekoop-Ruiterman, Y.P.3
  • 2
    • 31044442965 scopus 로고    scopus 로고
    • The PREMIER study: a multicenter, randomized, double-blind clinical trial of combination therapy with adalimumab plus methotrexate versus methotrexate alone or adalimumab alone in patients with early, aggressive rheumatoid arthritis who had not had previous methotrexate treatment
    • COI: 1:CAS:528:DC%2BD28XhsVens74%3D, PID: 16385520
    • Breedveld FC, Weisman MH, Kavanaugh AF, et al. The PREMIER study: a multicenter, randomized, double-blind clinical trial of combination therapy with adalimumab plus methotrexate versus methotrexate alone or adalimumab alone in patients with early, aggressive rheumatoid arthritis who had not had previous methotrexate treatment. Arthritis Rheum. 2006;54:26–37. DOI: 10.1002/art.21519
    • (2006) Arthritis Rheum , vol.54 , pp. 26-37
    • Breedveld, F.C.1    Weisman, M.H.2    Kavanaugh, A.F.3
  • 3
    • 48149100741 scopus 로고    scopus 로고
    • Comparison of methotrexate monotherapy with a combination of methotrexate and etanercept in active, early, moderate to severe rheumatoid arthritis (COMET): a randomised, double-blind, parallel treatment trial
    • COI: 1:CAS:528:DC%2BD1cXpt1GqtLY%3D, PID: 18635256
    • Emery P, Breedveld FC, Hall S, et al. Comparison of methotrexate monotherapy with a combination of methotrexate and etanercept in active, early, moderate to severe rheumatoid arthritis (COMET): a randomised, double-blind, parallel treatment trial. Lancet. 2008;372:375–82. DOI: 10.1016/S0140-6736(08)61000-4
    • (2008) Lancet , vol.372 , pp. 375-382
    • Emery, P.1    Breedveld, F.C.2    Hall, S.3
  • 4
    • 84893772728 scopus 로고    scopus 로고
    • EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2013 update
    • COI: 1:CAS:528:DC%2BC2cXmsFWkurk%3D, PID: 24161836
    • Smolen JS, Landewe R, Breedveld FC, et al. EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2013 update. Ann Rheum Dis. 2014;73:492–509. DOI: 10.1136/annrheumdis-2013-204573
    • (2014) Ann Rheum Dis , vol.73 , pp. 492-509
    • Smolen, J.S.1    Landewe, R.2    Breedveld, F.C.3
  • 5
    • 40749114497 scopus 로고    scopus 로고
    • Effect of interleukin-6 receptor inhibition with tocilizumab in patients with rheumatoid arthritis (OPTION study): a double-blind, placebo-controlled, randomised trial
    • COI: 1:CAS:528:DC%2BD1cXjs1Sltbc%3D, PID: 18358926
    • Smolen JS, Beaulieu A, Rubbert-Roth A, et al. Effect of interleukin-6 receptor inhibition with tocilizumab in patients with rheumatoid arthritis (OPTION study): a double-blind, placebo-controlled, randomised trial. Lancet. 2008;371:987–97. DOI: 10.1016/S0140-6736(08)60453-5
    • (2008) Lancet , vol.371 , pp. 987-997
    • Smolen, J.S.1    Beaulieu, A.2    Rubbert-Roth, A.3
  • 6
    • 52149099504 scopus 로고    scopus 로고
    • IL-6 receptor inhibition with tocilizumab improves treatment outcomes in patients with rheumatoid arthritis refractory to anti-tumour necrosis factor biologicals: results from a 24-week multicentre randomised placebo-controlled trial
    • COI: 1:CAS:528:DC%2BD1cXhtl2gsbbI, PID: 18625622
    • Emery P, Keystone E, Tony HP, et al. IL-6 receptor inhibition with tocilizumab improves treatment outcomes in patients with rheumatoid arthritis refractory to anti-tumour necrosis factor biologicals: results from a 24-week multicentre randomised placebo-controlled trial. Ann Rheum Dis. 2008;67:1516–23. DOI: 10.1136/ard.2008.092932
    • (2008) Ann Rheum Dis , vol.67 , pp. 1516-1523
    • Emery, P.1    Keystone, E.2    Tony, H.P.3
  • 7
    • 54949150604 scopus 로고    scopus 로고
    • Interleukin-6 receptor inhibition with tocilizumab reduces disease activity in rheumatoid arthritis with inadequate response to disease-modifying antirheumatic drugs: the tocilizumab in combination with traditional disease-modifying antirheumatic drug therapy study
    • COI: 1:CAS:528:DC%2BD1cXht12rur%2FJ, PID: 18821691
    • Genovese MC, McKay JD, Nasonov EL, et al. Interleukin-6 receptor inhibition with tocilizumab reduces disease activity in rheumatoid arthritis with inadequate response to disease-modifying antirheumatic drugs: the tocilizumab in combination with traditional disease-modifying antirheumatic drug therapy study. Arthritis Rheum. 2008;58:2968–80. DOI: 10.1002/art.23940
    • (2008) Arthritis Rheum , vol.58 , pp. 2968-2980
    • Genovese, M.C.1    McKay, J.D.2    Nasonov, E.L.3
  • 8
    • 79953680176 scopus 로고    scopus 로고
    • Tocilizumab inhibits structural joint damage in rheumatoid arthritis patients with inadequate responses to methotrexate: results from the double-blind treatment phase of a randomized placebo-controlled trial of tocilizumab safety and prevention of structural joint damage at one year
    • COI: 1:CAS:528:DC%2BC3MXksFWrsr4%3D, PID: 21360490
    • Kremer JM, Blanco R, Brzosko M, et al. Tocilizumab inhibits structural joint damage in rheumatoid arthritis patients with inadequate responses to methotrexate: results from the double-blind treatment phase of a randomized placebo-controlled trial of tocilizumab safety and prevention of structural joint damage at one year. Arthritis Rheum. 2011;63:609–21. DOI: 10.1002/art.30158
    • (2011) Arthritis Rheum , vol.63 , pp. 609-621
    • Kremer, J.M.1    Blanco, R.2    Brzosko, M.3
  • 9
    • 73449118587 scopus 로고    scopus 로고
    • Comparison of tocilizumab monotherapy versus methotrexate monotherapy in patients with moderate to severe rheumatoid arthritis: the AMBITION study
    • COI: 1:CAS:528:DC%2BC3cXhtFOls78%3D, PID: 19297346
    • Jones G, Sebba A, Gu J, et al. Comparison of tocilizumab monotherapy versus methotrexate monotherapy in patients with moderate to severe rheumatoid arthritis: the AMBITION study. Ann Rheum Dis. 2010;69:88–96. DOI: 10.1136/ard.2008.105197
    • (2010) Ann Rheum Dis , vol.69 , pp. 88-96
    • Jones, G.1    Sebba, A.2    Gu, J.3
  • 10
    • 85007277373 scopus 로고    scopus 로고
    • Subcutaneous tocilizumab versus placebo in combination with disease-modifying antirheumatic drugs in patients with rheumatoid arthritis
    • COI: 1:CAS:528:DC%2BC2cXhvVant7bP, PID: 24942540
    • Kivitz A, Olech E, Borofsky M, et al. Subcutaneous tocilizumab versus placebo in combination with disease-modifying antirheumatic drugs in patients with rheumatoid arthritis. Arthritis Care Res (Hoboken). 2014;66:1653–61. DOI: 10.1002/acr.22384
    • (2014) Arthritis Care Res (Hoboken). , vol.66 , pp. 1653-1661
    • Kivitz, A.1    Olech, E.2    Borofsky, M.3
  • 11
    • 84896689880 scopus 로고    scopus 로고
    • Phase III study of the efficacy and safety of subcutaneous versus intravenous tocilizumab monotherapy in patients with rheumatoid arthritis
    • COI: 1:CAS:528:DC%2BC2cXjtlOltbg%3D, PID: 23983039
    • Ogata A, Tanimura K, Sugimoto T, et al. Phase III study of the efficacy and safety of subcutaneous versus intravenous tocilizumab monotherapy in patients with rheumatoid arthritis. Arthritis Care Res (Hoboken). 2014;66:344–54. DOI: 10.1002/acr.22110
    • (2014) Arthritis Care Res (Hoboken). , vol.66 , pp. 344-354
    • Ogata, A.1    Tanimura, K.2    Sugimoto, T.3
  • 12
    • 84889667445 scopus 로고    scopus 로고
    • A randomised, double-blind, parallel-group study of the safety and efficacy of subcutaneous tocilizumab versus intravenous tocilizumab in combination with traditional disease-modifying antirheumatic drugs in patients with moderate to severe rheumatoid arthritis (SUMMACTA study)
    • COI: 1:CAS:528:DC%2BC2cXitValu7k%3D, PID: 23904473
    • Burmester GR, Rubbert-Roth A, Cantagrel A, et al. A randomised, double-blind, parallel-group study of the safety and efficacy of subcutaneous tocilizumab versus intravenous tocilizumab in combination with traditional disease-modifying antirheumatic drugs in patients with moderate to severe rheumatoid arthritis (SUMMACTA study). Ann Rheum Dis. 2014;73:69–74. DOI: 10.1136/annrheumdis-2013-203523
    • (2014) Ann Rheum Dis , vol.73 , pp. 69-74
    • Burmester, G.R.1    Rubbert-Roth, A.2    Cantagrel, A.3
  • 13
    • 84946887746 scopus 로고    scopus 로고
    • Tocilizumab in early progressive rheumatoid arthritis: FUNCTION, a randomised controlled trial
    • PID: 26511996
    • Burmester GR, Rigby WF, van Vollenhoven RF, et al. Tocilizumab in early progressive rheumatoid arthritis: FUNCTION, a randomised controlled trial. Ann Rheum Dis. 2016;75:1081–91. DOI: 10.1136/annrheumdis-2015-207628
    • (2016) Ann Rheum Dis , vol.75 , pp. 1081-1091
    • Burmester, G.R.1    Rigby, W.F.2    van Vollenhoven, R.F.3
  • 14
    • 84927621697 scopus 로고    scopus 로고
    • Tocilizumab in rheumatoid arthritis: a case study of safety evaluations of a large postmarketing data set from multiple data sources
    • COI: 1:CAS:528:DC%2BC2cXhslagsb%2FP, PID: 25300699
    • Curtis JR, Perez-Gutthann S, Suissa S, et al. Tocilizumab in rheumatoid arthritis: a case study of safety evaluations of a large postmarketing data set from multiple data sources. Semin Arthritis Rheum. 2015;44:381–8. DOI: 10.1016/j.semarthrit.2014.07.006
    • (2015) Semin Arthritis Rheum , vol.44 , pp. 381-388
    • Curtis, J.R.1    Perez-Gutthann, S.2    Suissa, S.3
  • 15
    • 21044442907 scopus 로고    scopus 로고
    • Peptic ulcer disease and related disorders
    • 18 edn. New York: McGraw-Hill
    • Del Valle J. Peptic ulcer disease and related disorders. Harrison’s principles of internal medicine, 18 edn. New York: McGraw-Hill; 2012. p. Ch. 293.
    • (2012) Harrison’s Principles of Internal Medicine , pp. 293
    • Del Valle, J.1
  • 16
    • 84863529243 scopus 로고    scopus 로고
    • Increased incidence and impact of upper and lower gastrointestinal events in patients with rheumatoid arthritis in Olmsted County, Minnesota: a longitudinal population-based study
    • PID: 22467929
    • Myasoedova E, Matteson EL, Talley NJ, Crowson CS. Increased incidence and impact of upper and lower gastrointestinal events in patients with rheumatoid arthritis in Olmsted County, Minnesota: a longitudinal population-based study. J Rheumatol. 2012;39:1355–62. DOI: 10.3899/jrheum.111311
    • (2012) J Rheumatol , vol.39 , pp. 1355-1362
    • Myasoedova, E.1    Matteson, E.L.2    Talley, N.J.3    Crowson, C.S.4
  • 17
    • 84870529267 scopus 로고    scopus 로고
    • Factors associated with gastrointestinal perforation in a cohort of patients with rheumatoid arthritis
    • PID: 22730417
    • Curtis JR, Lanas A, John A, Johnson DA, Schulman KL. Factors associated with gastrointestinal perforation in a cohort of patients with rheumatoid arthritis. Arthritis Care Res (Hoboken). 2012;64:1819–28. DOI: 10.1002/acr.21764
    • (2012) Arthritis Care Res (Hoboken). , vol.64 , pp. 1819-1828
    • Curtis, J.R.1    Lanas, A.2    John, A.3    Johnson, D.A.4    Schulman, K.L.5
  • 18
    • 79551657655 scopus 로고    scopus 로고
    • The incidence of gastrointestinal perforations among rheumatoid arthritis patients
    • PID: 20967860
    • Curtis JR, Xie F, Chen L, et al. The incidence of gastrointestinal perforations among rheumatoid arthritis patients. Arthritis Rheum. 2011;63:346–51. DOI: 10.1002/art.30107
    • (2011) Arthritis Rheum , vol.63 , pp. 346-351
    • Curtis, J.R.1    Xie, F.2    Chen, L.3
  • 19
    • 84925670384 scopus 로고    scopus 로고
    • Effect of interleukin-6 receptor blockade on surrogates of vascular risk in rheumatoid arthritis: MEASURE, a randomised, placebo-controlled study
    • COI: 1:CAS:528:DC%2BC2MXmsFygurw%3D, PID: 24368514
    • McInnes IB, Thompson L, Giles JT, et al. Effect of interleukin-6 receptor blockade on surrogates of vascular risk in rheumatoid arthritis: MEASURE, a randomised, placebo-controlled study. Ann Rheum Dis. 2015;74:694–702. DOI: 10.1136/annrheumdis-2013-204345
    • (2015) Ann Rheum Dis , vol.74 , pp. 694-702
    • McInnes, I.B.1    Thompson, L.2    Giles, J.T.3
  • 20
    • 84877275257 scopus 로고    scopus 로고
    • Tocilizumab monotherapy versus adalimumab monotherapy for treatment of rheumatoid arthritis (ADACTA): a randomised, double-blind, controlled phase 4 trial
    • COI: 1:CAS:528:DC%2BC3sXksFantLw%3D, PID: 23515142
    • Gabay C, Emery P, van Vollenhoven R, et al. Tocilizumab monotherapy versus adalimumab monotherapy for treatment of rheumatoid arthritis (ADACTA): a randomised, double-blind, controlled phase 4 trial. Lancet. 2013;381:1541–50. DOI: 10.1016/S0140-6736(13)60250-0
    • (2013) Lancet , vol.381 , pp. 1541-1550
    • Gabay, C.1    Emery, P.2    van Vollenhoven, R.3
  • 21
    • 80555150701 scopus 로고    scopus 로고
    • Validation of ICD-9-CM codes to identify gastrointestinal perforation events in administrative claims data among hospitalized rheumatoid arthritis patients
    • PID: 22020901
    • Curtis JR, Chen SY, Werther W, John A, Johnson DA. Validation of ICD-9-CM codes to identify gastrointestinal perforation events in administrative claims data among hospitalized rheumatoid arthritis patients. Pharmacoepidemiol Drug Saf. 2011;20:1150–8. DOI: 10.1002/pds.2215
    • (2011) Pharmacoepidemiol Drug Saf , vol.20 , pp. 1150-1158
    • Curtis, J.R.1    Chen, S.Y.2    Werther, W.3    John, A.4    Johnson, D.A.5
  • 22
    • 84992159273 scopus 로고    scopus 로고
    • Risk for gastrointestinal perforation among rheumatoid arthritis patients recieving tofacitinib, tocilizumab, or other biologics
    • Epub ahead of print
    • Xie F, Yun H, Bernatsky S, Curtis J. Risk for gastrointestinal perforation among rheumatoid arthritis patients recieving tofacitinib, tocilizumab, or other biologics. Arthritis Rheumatol. 2016. doi:10.1002/art39761 [Epub ahead of print]. DOI: 10.1002/art39761
    • (2016) Arthritis Rheumatol
    • Xie, F.1    Yun, H.2    Bernatsky, S.3    Curtis, J.4
  • 23
    • 84992560790 scopus 로고    scopus 로고
    • Risk for lower perforations in RA patients treated with tocilizumab in comparison to treatment with TNF inhibitors, rituximab, abatacept or conventional synthetic DMARDs [oral presentation]
    • Strangfeld A, Richter A, Herzer P, et al. Risk for lower perforations in RA patients treated with tocilizumab in comparison to treatment with TNF inhibitors, rituximab, abatacept or conventional synthetic DMARDs [oral presentation]. Arthritis Rheumatol. 2015;67(Suppl):S10.
    • (2015) Arthritis Rheumatol , vol.67 , pp. S10
    • Strangfeld, A.1    Richter, A.2    Herzer, P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.