Profile of sarilumab and its potential in the treatment of rheumatoid arthritis

Drug Design, Development and Therapy

Volumn 11, Issue , 2017, Pages 1593-1603

  Raimondo, Maria Gabriella ^a   Biggioggero, Martina ^a   Crotti, Chiara ^a   Becciolini, Andrea ^b   Favalli, Ennio Giulio ^b  

^a UNIVERSITY OF MILAN   (Italy)

^b ISTITUTO ORTOPEDICO GAETANO PINI   (Italy)

Author keywords

Biologic drugs; Interleukin 6; Monoclonal antibody; Rheumatoid arthritis; Sarilumab

Indexed keywords

ADALIMUMAB; ALANINE AMINOTRANSFERASE; C REACTIVE PROTEIN; CLAZAKIZUMAB; GLYCOPROTEIN GP 130; INTERLEUKIN 17; INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR; JANUS KINASE; METHOTREXATE; OLOKIZUMAB; PROTEIN TYROSINE PHOSPHATASE SHP 2; SARILUMAB; SIRUKUMAB; STAT PROTEIN; TOCILIZUMAB; VOBARILIZUMAB; ANTIRHEUMATIC AGENT; IL6 PROTEIN, HUMAN; IL6R PROTEIN, HUMAN; MONOCLONAL ANTIBODY;

ABSENCE OF SIDE EFFECTS; ALANINE AMINOTRANSFERASE BLOOD LEVEL; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DAS28; DISEASE COURSE; DRUG EFFICACY; DRUG HALF LIFE; DRUG SAFETY; DRUG TOLERABILITY; ENZYME ACTIVATION; HUMAN; INFECTION; LIVER TOXICITY; MULTICENTER STUDY (TOPIC); NEUTROPENIA; NEUTROPHIL COUNT; OBSERVATIONAL STUDY; OPEN STUDY; OPPORTUNISTIC INFECTION; PATHOGENESIS; PHASE 1 CLINICAL TRIAL (TOPIC); PHASE 2 CLINICAL TRIAL (TOPIC); PHASE 3 CLINICAL TRIAL (TOPIC); PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; RANDOMIZED CONTROLLED TRIAL (TOPIC); REMISSION; REVIEW; RHEUMATOID ARTHRITIS; SIDE EFFECT; SIGNAL TRANSDUCTION; TH17 CELL; THROMBOCYTE COUNT; TREATMENT RESPONSE; ANTAGONISTS AND INHIBITORS; COMBINATION DRUG THERAPY; DRUG EFFECTS; IMMUNOLOGY; TREATMENT OUTCOME;

ANTIBODIES, MONOCLONAL, HUMANIZED; ANTIRHEUMATIC AGENTS; ARTHRITIS, RHEUMATOID; DRUG THERAPY, COMBINATION; HUMANS; INTERLEUKIN-6; RECEPTORS, INTERLEUKIN-6; SIGNAL TRANSDUCTION; TREATMENT OUTCOME;

EID: 85019664560     PISSN: None     EISSN: 11778881     Source Type: Journal    
DOI: 10.2147/DDDT.S100302     Document Type: Review

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