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Volumn 9, Issue AUG, 2018, Pages

The role of Hepatocyte Growth Factor (HGF) in insulin resistance and diabetes

Author keywords

Beta cells; Diabetes; Hepatocyte growth factor; HGF; Inflammation; Insulin resistance; Obesity

Indexed keywords

ADENOSINE TRIPHOSPHATE; ANGIOTENSIN II; EPIDERMAL GROWTH FACTOR RECEPTOR; GLUCOSE TRANSPORTER 2; GLUCOSE TRANSPORTER 4; GLUCOSE TRANSPORTER 5; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 10; INTERLEUKIN 6; MAGNESIUM; MONOCYTE CHEMOTACTIC PROTEIN 1; PHOSPHATIDYLINOSITOL 3 KINASE; SCATTER FACTOR;

EID: 85052834782     PISSN: None     EISSN: 16642392     Source Type: Journal    
DOI: 10.3389/fendo.2018.00503     Document Type: Review
Times cited : (77)

References (119)
  • 1
    • 4444228888 scopus 로고    scopus 로고
    • WHO. Obesity and Overweight (2012), p. 311. Available online at: http://www.who.int/mediacentre/factsheets/fs311/en/
    • (2012) Obesity and Overweight , pp. 311
  • 2
    • 84900831302 scopus 로고    scopus 로고
    • Physiology in perspective: the burden of obesity
    • Sieck G. Physiology in perspective: the burden of obesity. Physiology (Bethesda) (2014) 29:86-7. doi: 10.1152/physiol.00004.2014
    • (2014) Physiology (Bethesda) , vol.29 , pp. 86-87
    • Sieck, G.1
  • 3
    • 84924066289 scopus 로고    scopus 로고
    • Obesity, inflammation, and the gut microbiota
    • Cox AJ, West NP, Cripps AW. Obesity, inflammation, and the gut microbiota. Lancet Diabet. Endocrinol. (2015) 3:207-15. doi: 10.1016/S2213-8587(14)70134-2
    • (2015) Lancet Diabet. Endocrinol , vol.3 , pp. 207-215
    • Cox, A.J.1    West, N.P.2    Cripps, A.W.3
  • 4
    • 0026438979 scopus 로고
    • Regulation of insulin receptor substrate-1 in liver and muscle of animal models of insulin resistance
    • Saad MJ, Araki E, Miralpeix M, Rothenberg PL, White MF, Kahn CR. Regulation of insulin receptor substrate-1 in liver and muscle of animal models of insulin resistance. J Clin Invest. (1992) 90:1839-49. doi: 10.1172/JCI116060
    • (1992) J Clin Invest , vol.90 , pp. 1839-1849
    • Saad, M.J.1    Araki, E.2    Miralpeix, M.3    Rothenberg, P.L.4    White, M.F.5    Kahn, C.R.6
  • 5
    • 0033913213 scopus 로고    scopus 로고
    • Signaling pathways in insulin action: molecular targets of insulin resistance
    • Pessin JE, Saltiel AR. Signaling pathways in insulin action: molecular targets of insulin resistance. J Clin Invest. (2000) 106:165-9. doi: 10.1172/JCI10582
    • (2000) J Clin Invest , vol.106 , pp. 165-169
    • Pessin, J.E.1    Saltiel, A.R.2
  • 6
    • 79953046341 scopus 로고    scopus 로고
    • Inflammatory mechanisms in obesity
    • Gregor MF, Hotamisligil GS. Inflammatory mechanisms in obesity. Ann Rev Immunol. (2011) 29:415-45. doi: 10.1146/annurev-immunol-031210-101322
    • (2011) Ann Rev Immunol , vol.29 , pp. 415-445
    • Gregor, M.F.1    Hotamisligil, G.S.2
  • 7
    • 65649098029 scopus 로고    scopus 로고
    • Phosphorylation of IRS proteins, insulin action, and insulin resistance
    • Boura-Halfon S, Zick Y. Phosphorylation of IRS proteins, insulin action, and insulin resistance. Am J Physiol Endocrinol Metab. (2009) 296:E581-91. doi: 10.1152/ajpendo.90437.2008
    • (2009) Am J Physiol Endocrinol Metab , vol.296 , pp. E581-E91
    • Boura-Halfon, S.1    Zick, Y.2
  • 8
    • 79151478555 scopus 로고    scopus 로고
    • Type 2 diabetes as an inflammatory disease
    • Donath MY, Shoelson SE. Type 2 diabetes as an inflammatory disease. Nat Rev Immunol. (2011) 11:98-107. doi: 10.1038/nri2925
    • (2011) Nat Rev Immunol , vol.11 , pp. 98-107
    • Donath, M.Y.1    Shoelson, S.E.2
  • 9
    • 77955806634 scopus 로고    scopus 로고
    • JNK1 and IKKbeta: molecular links between obesity and metabolic dysfunction
    • Solinas G, Karin M. JNK1 and IKKbeta: molecular links between obesity and metabolic dysfunction. FASEB J. (2010) 24:2596-611. doi: 10.1096/fj.09-151340
    • (2010) FASEB J , vol.24 , pp. 2596-2611
    • Solinas, G.1    Karin, M.2
  • 10
    • 84938420461 scopus 로고    scopus 로고
    • The economic costs of type 2 diabetes: a global systematic review
    • Seuring T, Archangelidi O, Suhrcke M. The economic costs of type 2 diabetes: a global systematic review. Pharm Econ. (2015) 33:811-31. doi: 10.1007/s40273-015-0268-9
    • (2015) Pharm Econ , vol.33 , pp. 811-831
    • Seuring, T.1    Archangelidi, O.2    Suhrcke, M.3
  • 11
    • 84975856269 scopus 로고    scopus 로고
    • in 2012
    • Economic costs of diabetes in the U.S. in 2012. Diabetes Care (2013) 36:1033-46. doi: 10.2337/dc12-2625
    • (2013) Diabetes Care , vol.36 , pp. 1033-1046
  • 12
    • 33845881411 scopus 로고    scopus 로고
    • Mechanisms linking obesity to insulin resistance and type 2 diabetes
    • Kahn SE, Hull RL, Utzschneider KM. Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature (2006) 444, 840-6. doi: 10.1038/nature05482
    • (2006) Nature , vol.444 , pp. 840-846
    • Kahn, S.E.1    Hull, R.L.2    Utzschneider, K.M.3
  • 13
    • 33745861300 scopus 로고    scopus 로고
    • Inflammation and insulin resistance
    • Shoelson SE, Lee J, Goldfine AB. Inflammation and insulin resistance. J Clin Invest. (2006) 116:1793-801. doi: 10.1172/JCI29069
    • (2006) J Clin Invest , vol.116 , pp. 1793-1801
    • Shoelson, S.E.1    Lee, J.2    Goldfine, A.B.3
  • 14
    • 84875549943 scopus 로고    scopus 로고
    • The role of hepatokines in metabolism
    • Stefan N, Haring HU. The role of hepatokines in metabolism. Nat Rev Endocrinol. (2013) 9:144-52. doi: 10.1038/nrendo.2012.258
    • (2013) Nat Rev Endocrinol , vol.9 , pp. 144-152
    • Stefan, N.1    Haring, H.U.2
  • 15
    • 79959517565 scopus 로고    scopus 로고
    • Human fatty liver disease: old questions and new insights
    • Cohen JC, Horton JD, Hobbs HH. Human fatty liver disease: old questions and new insights. Science (2011) 332:1519-23. doi: 10.1126/science.1204265
    • (2011) Science , vol.332 , pp. 1519-1523
    • Cohen, J.C.1    Horton, J.D.2    Hobbs, H.H.3
  • 16
    • 0032797852 scopus 로고    scopus 로고
    • Regulation of glucose production by the liver
    • Nordlie RC, Foster JD, Lange AJ. Regulation of glucose production by the liver. Ann Rev Nutr. (1999) 19:379-406. doi: 10.1146/annurev.nutr.19.1.379
    • (1999) Ann Rev Nutr , vol.19 , pp. 379-406
    • Nordlie, R.C.1    Foster, J.D.2    Lange, A.J.3
  • 17
    • 85028589380 scopus 로고    scopus 로고
    • Hepatokines: linking nonalcoholic fatty liver disease and insulin resistance
    • Meex RCR, Watt MJ. Hepatokines: linking nonalcoholic fatty liver disease and insulin resistance. Nat. Rev. Endocrinol. (2017) 13:509-20. doi: 10.1038/nrendo.2017.56
    • (2017) Nat. Rev. Endocrinol , vol.13 , pp. 509-520
    • Meex, R.C.R.1    Watt, M.J.2
  • 18
    • 85003758672 scopus 로고    scopus 로고
    • Association between serum fibroblast growth factor 21 and mortality among patients with coronary artery disease
    • Li Q, Zhang Y, Ding D, Yang Y, Chen Q, Su D, et al. Association between serum fibroblast growth factor 21 and mortality among patients with coronary artery disease. J Clin Endocrinol Metab. (2016) 101:4886-94. doi: 10.1210/jc.2016-2308
    • (2016) J Clin Endocrinol Metab , vol.101 , pp. 4886-4894
    • Li, Q.1    Zhang, Y.2    Ding, D.3    Yang, Y.4    Chen, Q.5    Su, D.6
  • 19
    • 84878592678 scopus 로고    scopus 로고
    • Independent association of elevated serum hepatocyte growth factor levels with development of insulin resistance in a 10-year prospective study
    • Tsukagawa E, Adachi H, Hirai Y, Enomoto M, Fukami A, Ogata K, et al. Independent association of elevated serum hepatocyte growth factor levels with development of insulin resistance in a 10-year prospective study. Clin Endocrinol. (Oxf.) (2013) 79:43-8. doi: 10.1111/j.1365-2265.2012.04496.x
    • (2013) Clin Endocrinol. (Oxf.) , vol.79 , pp. 43-48
    • Tsukagawa, E.1    Adachi, H.2    Hirai, Y.3    Enomoto, M.4    Fukami, A.5    Ogata, K.6
  • 20
    • 0028558775 scopus 로고
    • Role of hepatocyte growth factor in breast cancer: a novel mitogenic factor secreted by adipocytes
    • Rahimi N, Saulnier R, Nakamura T, Park M, Elliott B. Role of hepatocyte growth factor in breast cancer: a novel mitogenic factor secreted by adipocytes. DNA Cell Biol. (1994) 13:1189-97
    • (1994) DNA Cell Biol , vol.13 , pp. 1189-1197
    • Rahimi, N.1    Saulnier, R.2    Nakamura, T.3    Park, M.4    Elliott, B.5
  • 21
    • 2042480671 scopus 로고    scopus 로고
    • Comparison of the release of adipokines by adipose tissue, adipose tissue matrix, and adipocytes from visceral and subcutaneous abdominal adipose tissues of obese humans
    • Fain JN, Madan AK, Hiler ML, Cheema P, Bahouth SW. Comparison of the release of adipokines by adipose tissue, adipose tissue matrix, and adipocytes from visceral and subcutaneous abdominal adipose tissues of obese humans. Endocrinology (2004) 145:2273-82. doi: 10.1210/en.2003-1336
    • (2004) Endocrinology , vol.145 , pp. 2273-2282
    • Fain, J.N.1    Madan, A.K.2    Hiler, M.L.3    Cheema, P.4    Bahouth, S.W.5
  • 24
    • 39349090237 scopus 로고    scopus 로고
    • Genetic and environmental determinants of hepatocyte growth factor levels and their association with obesity and blood pressure
    • Vistoropsky Y, Trofimov S, Malkin I, Kobyliansky E, Livshits G. Genetic and environmental determinants of hepatocyte growth factor levels and their association with obesity and blood pressure. Ann Hum Biol. (2008) 35:93-103. doi: 10.1080/03014460701822003
    • (2008) Ann Hum Biol , vol.35 , pp. 93-103
    • Vistoropsky, Y.1    Trofimov, S.2    Malkin, I.3    Kobyliansky, E.4    Livshits, G.5
  • 25
    • 34249847369 scopus 로고    scopus 로고
    • Hepatocyte growth factor induces glucose uptake in 3T3-L1 adipocytes through A Gab1/phosphatidylinositol 3-kinase/Glut4 pathway
    • Bertola A, Bonnafous S, Cormont M, Anty R, Tanti JF, Tran A, et al. Hepatocyte growth factor induces glucose uptake in 3T3-L1 adipocytes through A Gab1/phosphatidylinositol 3-kinase/Glut4 pathway. J Biol Chem. (2007) 282:10325-32. doi: 10.1074/jbc.M611770200
    • (2007) J Biol Chem , vol.282 , pp. 10325-10332
    • Bertola, A.1    Bonnafous, S.2    Cormont, M.3    Anty, R.4    Tanti, J.F.5    Tran, A.6
  • 26
    • 84862564234 scopus 로고    scopus 로고
    • The secretion pattern of perivascular fat cells is different from that of subcutaneous and visceral fat cells
    • Rittig K, Dolderer JH, Balletshofer B, Machann J, Schick F, Meile T, et al. The secretion pattern of perivascular fat cells is different from that of subcutaneous and visceral fat cells. Diabetologia (2012) 55:1514-25. doi: 10.1007/s00125-012-2481-9
    • (2012) Diabetologia , vol.55 , pp. 1514-1525
    • Rittig, K.1    Dolderer, J.H.2    Balletshofer, B.3    Machann, J.4    Schick, F.5    Meile, T.6
  • 27
    • 0344406152 scopus 로고    scopus 로고
    • Obesity is associated with increased levels of circulating hepatocyte growth factor
    • Rehman J, Considine RV, Bovenkerk JE, Li J, Slavens CA, Jones RM, et al. Obesity is associated with increased levels of circulating hepatocyte growth factor. J Am Coll Cardiol. (2003) 41:1408-13. doi: 10.1016/S0735-1097(03)00231-6
    • (2003) J Am Coll Cardiol , vol.41 , pp. 1408-1413
    • Rehman, J.1    Considine, R.V.2    Bovenkerk, J.E.3    Li, J.4    Slavens, C.A.5    Jones, R.M.6
  • 28
    • 21344468811 scopus 로고    scopus 로고
    • Serum hepatocyte growth factor concentration in obese women decreases after vertical banded gastroplasty
    • Swierczynski J, Korczynska J, Goyke E, Adrych K, Raczynska S, Sledzinski Z. Serum hepatocyte growth factor concentration in obese women decreases after vertical banded gastroplasty. Obes Surg. (2005) 15:803-8. doi: 10.1381/0960892054222678
    • (2005) Obes Surg , vol.15 , pp. 803-808
    • Swierczynski, J.1    Korczynska, J.2    Goyke, E.3    Adrych, K.4    Raczynska, S.5    Sledzinski, Z.6
  • 29
    • 84900037462 scopus 로고    scopus 로고
    • Visceral adiposity index (VAI) is predictive of an altered adipokine profile in patients with type 2 diabetes
    • Amato MC, Pizzolanti G, Torregrossa V, Misiano G, Milano S, Giordano C. Visceral adiposity index (VAI) is predictive of an altered adipokine profile in patients with type 2 diabetes. PLoS ONE (2014) 9:e91969. doi: 10.1371/journal.pone.0091969
    • (2014) PLoS ONE , vol.9
    • Amato, M.C.1    Pizzolanti, G.2    Torregrossa, V.3    Misiano, G.4    Milano, S.5    Giordano, C.6
  • 31
    • 84856113332 scopus 로고    scopus 로고
    • A hepatocyte growth factor receptor (Met)-insulin receptor hybrid governs hepatic glucose metabolism
    • Fafalios A, Ma J, Tan X, Stoops J, Luo J, Defrances MC, et al. A hepatocyte growth factor receptor (Met)-insulin receptor hybrid governs hepatic glucose metabolism. Nat Med. (2011) 17:1577-84. doi: 10.1038/nm.2531
    • (2011) Nat Med , vol.17 , pp. 1577-1584
    • Fafalios, A.1    Ma, J.2    Tan, X.3    Stoops, J.4    Luo, J.5    Defrances, M.C.6
  • 32
    • 0035650568 scopus 로고    scopus 로고
    • Transgenic overexpression of hepatocyte growth factor in the β-cell markedly improves islet function and islet transplant outcomes in mice
    • Garcia-Ocana A, Vasavada RC, Cebrian A, Reddy V, Takane KK, Lopez-Talavera JC, et al. Transgenic overexpression of hepatocyte growth factor in the β-cell markedly improves islet function and islet transplant outcomes in mice. Diabetes (2001) 50:2752-62. doi: 10.2337/diabetes.50.12.2752
    • (2001) Diabetes , vol.50 , pp. 2752-2762
    • Garcia-Ocana, A.1    Vasavada, R.C.2    Cebrian, A.3    Reddy, V.4    Takane, K.K.5    Lopez-Talavera, J.C.6
  • 33
    • 21344442148 scopus 로고    scopus 로고
    • Targeted inactivation of hepatocyte growth factor receptor c-met in beta-cells leads to defective insulin secretion and GLUT-2 downregulation without alteration of β-cell mass
    • Roccisana J, Reddy V, Vasavada RC, Gonzalez-Pertusa JA, Magnuson MA, Garcia-Ocana A. Targeted inactivation of hepatocyte growth factor receptor c-met in beta-cells leads to defective insulin secretion and GLUT-2 downregulation without alteration of β-cell mass. Diabetes (2005) 54:2090-102. doi: 10.2337/diabetes.54.7.2090
    • (2005) Diabetes , vol.54 , pp. 2090-2102
    • Roccisana, J.1    Reddy, V.2    Vasavada, R.C.3    Gonzalez-Pertusa, J.A.4    Magnuson, M.A.5    Garcia-Ocana, A.6
  • 34
    • 0031985941 scopus 로고    scopus 로고
    • Hepatocyte growth factor up-regulates SGLT1 and GLUT5 gene expression after massive small bowel resection
    • Kato Y, Yu D, Schwartz MZ. Hepatocyte growth factor up-regulates SGLT1 and GLUT5 gene expression after massive small bowel resection. J Pediatr Surg. (1998) 33:13-5
    • (1998) J Pediatr Surg , vol.33 , pp. 13-15
    • Kato, Y.1    Yu, D.2    Schwartz, M.Z.3
  • 35
    • 46649121742 scopus 로고    scopus 로고
    • Hepatocyte growth factor is a novel stimulator of glucose uptake and metabolism in skeletal muscle cells
    • Perdomo G, Martinez-Brocca MA, Bhatt BA, Brown NF, O'Doherty RM, Garcia-Ocana A. Hepatocyte growth factor is a novel stimulator of glucose uptake and metabolism in skeletal muscle cells. J Biol Chem. (2008) 283:13700-6. doi: 10.1074/jbc.M707551200
    • (2008) J Biol Chem , vol.283 , pp. 13700-13706
    • Perdomo, G.1    Martinez-Brocca, M.A.2    Bhatt, B.A.3    Brown, N.F.4    O'Doherty, R.M.5    Garcia-Ocana, A.6
  • 36
    • 84949319409 scopus 로고    scopus 로고
    • Targeted delivery of HGF to the skeletal muscle improves glucose homeostasis in diet-induced obese mice
    • Sanchez-Encinales V, Cozar-Castellano I, Garcia-Ocana A, Perdomo G. Targeted delivery of HGF to the skeletal muscle improves glucose homeostasis in diet-induced obese mice. J Physiol Biochem. (2015) 71:795-805. doi: 10.1007/s13105-015-0444-6
    • (2015) J Physiol Biochem , vol.71 , pp. 795-805
    • Sanchez-Encinales, V.1    Cozar-Castellano, I.2    Garcia-Ocana, A.3    Perdomo, G.4
  • 37
    • 84870169776 scopus 로고    scopus 로고
    • Hepatocyte growth factor plays a key role in insulin resistance-associated compensatory mechanisms
    • Araujo TG, Oliveira AG, Carvalho BM, Guadagnini D, Protzek AO, Carvalheira JB, et al. Hepatocyte growth factor plays a key role in insulin resistance-associated compensatory mechanisms. Endocrinology (2012) 153:5760-9. doi: 10.1210/en.2012-1496
    • (2012) Endocrinology , vol.153 , pp. 5760-5769
    • Araujo, T.G.1    Oliveira, A.G.2    Carvalho, B.M.3    Guadagnini, D.4    Protzek, A.O.5    Carvalheira, J.B.6
  • 38
    • 84860585020 scopus 로고    scopus 로고
    • Loss of HGF/c-Met signaling in pancreatic beta-cells leads to incomplete maternal beta-cell adaptation and gestational diabetes mellitus
    • Demirci C, Ernst S, Alvarez-Perez JC, Rosa T, Valle S, Shridhar V, et al. Loss of HGF/c-Met signaling in pancreatic beta-cells leads to incomplete maternal beta-cell adaptation and gestational diabetes mellitus. Diabetes (2012) 61:1143-52. doi: 10.2337/db11-1154
    • (2012) Diabetes , vol.61 , pp. 1143-1152
    • Demirci, C.1    Ernst, S.2    Alvarez-Perez, J.C.3    Rosa, T.4    Valle, S.5    Shridhar, V.6
  • 39
    • 84893045655 scopus 로고    scopus 로고
    • Insulin-resistance-associated compensatory mechanisms of pancreatic Beta cells: a current opinion
    • Araujo TG, Oliveira AG, Saad MJ. Insulin-resistance-associated compensatory mechanisms of pancreatic Beta cells: a current opinion. Front Endocrinol. (2013) 4:146. doi: 10.3389/fendo.2013.00146
    • (2013) Front Endocrinol , vol.4 , pp. 146
    • Araujo, T.G.1    Oliveira, A.G.2    Saad, M.J.3
  • 40
    • 0028284507 scopus 로고
    • Hepatocyte growth factor/scatter factor has insulinotropic activity in human fetal pancreatic cells
    • Otonkoski T, Beattie GM, Rubin JS, Lopez AD, Baird A, Hayek A. Hepatocyte growth factor/scatter factor has insulinotropic activity in human fetal pancreatic cells. Diabetes (1994) 43:947-53
    • (1994) Diabetes , vol.43 , pp. 947-953
    • Otonkoski, T.1    Beattie, G.M.2    Rubin, J.S.3    Lopez, A.D.4    Baird, A.5    Hayek, A.6
  • 41
    • 0030015057 scopus 로고    scopus 로고
    • A role for hepatocyte growth factor/scatter factor in fetal mesenchyme-induced pancreatic beta-cell growth
    • Otonkoski T, Cirulli V, Beattie M, Mally MI, Soto G, Rubin JS, et al. A role for hepatocyte growth factor/scatter factor in fetal mesenchyme-induced pancreatic beta-cell growth. Endocrinology (1996) 137:3131-9
    • (1996) Endocrinology , vol.137 , pp. 3131-3139
    • Otonkoski, T.1    Cirulli, V.2    Beattie, M.3    Mally, M.I.4    Soto, G.5    Rubin, J.S.6
  • 43
    • 25144464664 scopus 로고    scopus 로고
    • Beta-cell-specific ablation of the hepatocyte growth factor receptor results in reduced islet size, impaired insulin secretion, and glucose intolerance
    • Dai C, Huh CG, Thorgeirsson SS, Liu Y. Beta-cell-specific ablation of the hepatocyte growth factor receptor results in reduced islet size, impaired insulin secretion, and glucose intolerance. Am J Pathol. (2005) 167:429-36. doi: 10.1016/S0002-9440(10)62987-2
    • (2005) Am J Pathol , vol.167 , pp. 429-436
    • Dai, C.1    Huh, C.G.2    Thorgeirsson, S.S.3    Liu, Y.4
  • 44
    • 84914148587 scopus 로고    scopus 로고
    • Hepatocyte growth factor ameliorates hyperglycemia and corrects beta-cell mass in IRS2-deficient mice
    • Alvarez-Perez JC, Rosa TC, Casinelli GP, Valle SR, Lakshmipathi J, Rosselot C, et al. Hepatocyte growth factor ameliorates hyperglycemia and corrects beta-cell mass in IRS2-deficient mice. Mol Endocrinol. (2014) 28:2038-48. doi: 10.1210/me.2014-1207
    • (2014) Mol Endocrinol , vol.28 , pp. 2038-2048
    • Alvarez-Perez, J.C.1    Rosa, T.C.2    Casinelli, G.P.3    Valle, S.R.4    Lakshmipathi, J.5    Rosselot, C.6
  • 46
    • 79551576937 scopus 로고    scopus 로고
    • Disruption of hepatocyte growth factor/c-Met signaling enhances pancreatic beta-cell death and accelerates the onset of diabetes
    • Mellado-Gil J, Rosa TC, Demirci C, Gonzalez-Pertusa JA, Velazquez-Garcia S, Ernst S, et al. Disruption of hepatocyte growth factor/c-Met signaling enhances pancreatic beta-cell death and accelerates the onset of diabetes. Diabetes (2011) 60:525-36. doi: 10.2337/db09-1305
    • (2011) Diabetes , vol.60 , pp. 525-536
    • Mellado-Gil, J.1    Rosa, T.C.2    Demirci, C.3    Gonzalez-Pertusa, J.A.4    Velazquez-Garcia, S.5    Ernst, S.6
  • 47
    • 0033954474 scopus 로고    scopus 로고
    • Hepatocyte growth factor overexpression in the islet of transgenic mice increases beta cell proliferation, enhances islet mass, and induces mild hypoglycemia
    • Garcia-Ocana A, Takane KK, Syed MA, Philbrick WM, Vasavada RC, Stewart AF. Hepatocyte growth factor overexpression in the islet of transgenic mice increases beta cell proliferation, enhances islet mass, and induces mild hypoglycemia. J Biol Chem. (2000) 275:1226-32. doi: 10.1074/jbc.275.2.1226
    • (2000) J Biol Chem , vol.275 , pp. 1226-1232
    • Garcia-Ocana, A.1    Takane, K.K.2    Syed, M.A.3    Philbrick, W.M.4    Vasavada, R.C.5    Stewart, A.F.6
  • 48
    • 78149492010 scopus 로고    scopus 로고
    • Hepatocyte growth factor modulates interleukin-6 production in bone marrow derived macrophages: implications for inflammatory mediated diseases
    • Coudriet GM, He J, Trucco M, Mars WM, Piganelli JD. Hepatocyte growth factor modulates interleukin-6 production in bone marrow derived macrophages: implications for inflammatory mediated diseases. PLoS ONE (2010) 5:e15384. doi: 10.1371/journal.pone.0015384
    • (2010) PLoS ONE , vol.5
    • Coudriet, G.M.1    He, J.2    Trucco, M.3    Mars, W.M.4    Piganelli, J.D.5
  • 49
    • 84866364363 scopus 로고    scopus 로고
    • Hepatocyte growth factor gene therapy enhances infiltration of macrophages and may induce kidney repair in db/db mice as a model of diabetes
    • Flaquer M, Franquesa M, Vidal A, Bolanos N, Torras J, Lloberas N, et al. Hepatocyte growth factor gene therapy enhances infiltration of macrophages and may induce kidney repair in db/db mice as a model of diabetes. Diabetologia (2012). doi: 10.1007/s00125-012-2535-z
    • (2012) Diabetologia
    • Flaquer, M.1    Franquesa, M.2    Vidal, A.3    Bolanos, N.4    Torras, J.5    Lloberas, N.6
  • 50
    • 84871884475 scopus 로고    scopus 로고
    • Hepatocyte growth factor inhibits lipopolysaccharide-induced oxidative stress via epithelial growth factor receptor degradation
    • Shimizu K, Taniyama Y, Sanada F, Azuma J, Iwabayashi M, Iekushi K, et al. Hepatocyte growth factor inhibits lipopolysaccharide-induced oxidative stress via epithelial growth factor receptor degradation. Arterioscler Thromb Vasc Biol. (2012) 32:2687-93. doi: 10.1161/ATVBAHA.112.300041
    • (2012) Arterioscler Thromb Vasc Biol , vol.32 , pp. 2687-2693
    • Shimizu, K.1    Taniyama, Y.2    Sanada, F.3    Azuma, J.4    Iwabayashi, M.5    Iekushi, K.6
  • 51
    • 84901983235 scopus 로고    scopus 로고
    • Anti-inflammatory effects of hepatocyte growth factor on the vicious cycle of macrophages and adipocytes
    • Kusunoki H, Taniyama Y, Otsu R, Rakugi H, Morishita R. Anti-inflammatory effects of hepatocyte growth factor on the vicious cycle of macrophages and adipocytes. Hypertens Res. (2014) 37:500-6. doi: 10.1038/hr.2014.41
    • (2014) Hypertens Res , vol.37 , pp. 500-506
    • Kusunoki, H.1    Taniyama, Y.2    Otsu, R.3    Rakugi, H.4    Morishita, R.5
  • 52
    • 0024427178 scopus 로고
    • Molecular cloning and expression of human hepatocyte growth factor
    • Nakamura T, Nishizawa T, Hagiya M, Seki T, Shimonishi M, Sugimura A, et al. Molecular cloning and expression of human hepatocyte growth factor. Nature (1989) 342:440-3. doi: 10.1038/342440a0
    • (1989) Nature , vol.342 , pp. 440-443
    • Nakamura, T.1    Nishizawa, T.2    Hagiya, M.3    Seki, T.4    Shimonishi, M.5    Sugimura, A.6
  • 53
    • 78650770246 scopus 로고    scopus 로고
    • Hepatocyte growth factor twenty years on: Much more than a growth factor
    • Nakamura T, Sakai K, Matsumoto K. Hepatocyte growth factor twenty years on: Much more than a growth factor. J Gastroenterol Hepatol. (2011) 26(Suppl. 1):188-202. doi: 10.1111/j.1440-1746.2010.06549.x
    • (2011) J Gastroenterol Hepatol , vol.26 , pp. 188-202
    • Nakamura, T.1    Sakai, K.2    Matsumoto, K.3
  • 54
    • 85047685412 scopus 로고    scopus 로고
    • Hepatocyte growth factor (HGF) enhances engraftment and function of non-human primate islets
    • Fiaschi-Taesch NM, Berman DM, Sicari BM, Takane KK, Garcia-Ocana A, Ricordi C, et al. Hepatocyte growth factor (HGF) enhances engraftment and function of non-human primate islets. Diabetes (2008) 57: 2745-54. doi: 10.2337/db07-1085
    • (2008) Diabetes , vol.57 , pp. 2745-2754
    • Fiaschi-Taesch, N.M.1    Berman, D.M.2    Sicari, B.M.3    Takane, K.K.4    Garcia-Ocana, A.5    Ricordi, C.6
  • 55
    • 0025862023 scopus 로고
    • Organization of the human hepatocyte growth factor-encoding gene
    • Seki T, Hagiya M, Shimonishi M, Nakamura T, Shimizu S. Organization of the human hepatocyte growth factor-encoding gene. Gene (1991) 102:213-9
    • (1991) Gene , vol.102 , pp. 213-219
    • Seki, T.1    Hagiya, M.2    Shimonishi, M.3    Nakamura, T.4    Shimizu, S.5
  • 56
    • 0032730169 scopus 로고    scopus 로고
    • HGF: a multifunctional growth factor controlling cell scattering
    • Stella MC, Comoglio PM. HGF: a multifunctional growth factor controlling cell scattering. Int J Biochem Cell Biol. (1999) 31:1357-62
    • (1999) Int J Biochem Cell Biol , vol.31 , pp. 1357-1362
    • Stella, M.C.1    Comoglio, P.M.2
  • 57
    • 0026699904 scopus 로고
    • Activation of hepatocyte growth factor by proteolytic conversion of a single chain form to a heterodimer
    • Naka D, Ishii T, Yoshiyama Y, Miyazawa K, Hara H, Hishida T, et al. Activation of hepatocyte growth factor by proteolytic conversion of a single chain form to a heterodimer. J Biol Chem. (1992) 267:20114-9
    • (1992) J Biol Chem , vol.267 , pp. 20114-20119
    • Naka, D.1    Ishii, T.2    Yoshiyama, Y.3    Miyazawa, K.4    Hara, H.5    Hishida, T.6
  • 58
    • 0028305195 scopus 로고
    • Proteolytic activation of hepatocyte growth factor in response to tissue injury
    • Miyazawa K, Shimomura T, Naka D, Kitamura N. Proteolytic activation of hepatocyte growth factor in response to tissue injury. J Biol Chem. (1994) 269:8966-70
    • (1994) J Biol Chem , vol.269 , pp. 8966-8970
    • Miyazawa, K.1    Shimomura, T.2    Naka, D.3    Kitamura, N.4
  • 59
    • 0028912994 scopus 로고
    • Activation of hepatocyte growth factor by two homologous proteases, blood-coagulation factor XIIa and hepatocyte growth factor activator
    • Shimomura T, Miyazawa K, Komiyama Y, Hiraoka H, Naka D, Morimoto Y, et al. Activation of hepatocyte growth factor by two homologous proteases, blood-coagulation factor XIIa and hepatocyte growth factor activator. Eur J Biochem. (1995) 229:257-61
    • (1995) Eur J Biochem , vol.229 , pp. 257-261
    • Shimomura, T.1    Miyazawa, K.2    Komiyama, Y.3    Hiraoka, H.4    Naka, D.5    Morimoto, Y.6
  • 60
    • 0034712902 scopus 로고    scopus 로고
    • Mouse hepatocyte growth factor activator gene: its expression not only in the liver but also in the gastrointestinal tract
    • Itoh H, Hamasuna R, Kataoka H, Yamauchi M, Miyazawa K, Kitamura N, et al. Mouse hepatocyte growth factor activator gene: its expression not only in the liver but also in the gastrointestinal tract. Biochim Biophys Acta (2000) 1491:295-302. doi: 10.1016/S0167-4781(00)00029-4
    • (2000) Biochim Biophys Acta , vol.1491 , pp. 295-302
    • Itoh, H.1    Hamasuna, R.2    Kataoka, H.3    Yamauchi, M.4    Miyazawa, K.5    Kitamura, N.6
  • 61
    • 29744452649 scopus 로고    scopus 로고
    • Administration of rhHGF-activator via portal vein stimulates the regeneration of cirrhotic liver after partial hepatectomy in rats
    • Yanagida H, Kaibori M, Hijikawa T, Kwon AH, Kamiyama Y, Okumura T. Administration of rhHGF-activator via portal vein stimulates the regeneration of cirrhotic liver after partial hepatectomy in rats. J Surg Res. (2006) 130:38-44. doi: 10.1016/j.jss.2005.08.002
    • (2006) J Surg Res , vol.130 , pp. 38-44
    • Yanagida, H.1    Kaibori, M.2    Hijikawa, T.3    Kwon, A.H.4    Kamiyama, Y.5    Okumura, T.6
  • 62
    • 0027373246 scopus 로고
    • Activation of the zymogen of hepatocyte growth factor activator by thrombin
    • Shimomura T, Kondo J, Ochiai M, Naka D, Miyazawa K, Morimoto Y, et al. Activation of the zymogen of hepatocyte growth factor activator by thrombin. J Biol Chem. (1993) 268:22927-32
    • (1993) J Biol Chem , vol.268 , pp. 22927-22932
    • Shimomura, T.1    Kondo, J.2    Ochiai, M.3    Naka, D.4    Miyazawa, K.5    Morimoto, Y.6
  • 63
    • 34250749673 scopus 로고    scopus 로고
    • Protein C inhibitor directly and potently inhibits activated hepatocyte growth factor activator
    • Hayashi T, Nishioka J, Nakagawa N, Kamada H, Gabazza EC, Kobayashi T, et al. Protein C inhibitor directly and potently inhibits activated hepatocyte growth factor activator. J Thromb Haemost. (2007) 5:1477-85. doi: 10.1111/j.1538-7836.2007.02594.x
    • (2007) J Thromb Haemost , vol.5 , pp. 1477-1485
    • Hayashi, T.1    Nishioka, J.2    Nakagawa, N.3    Kamada, H.4    Gabazza, E.C.5    Kobayashi, T.6
  • 64
    • 0026485023 scopus 로고
    • A functional domain in the heavy chain of scatter factor/hepatocyte growth factor binds the c-Met receptor and induces cell dissociation but not mitogenesis
    • Hartmann G, Naldini L, Weidner KM, Sachs M, Vigna E, Comoglio PM, et al. A functional domain in the heavy chain of scatter factor/hepatocyte growth factor binds the c-Met receptor and induces cell dissociation but not mitogenesis. Proc Natl Acad Sci USA (1992) 89:11574-8
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 11574-11578
    • Hartmann, G.1    Naldini, L.2    Weidner, K.M.3    Sachs, M.4    Vigna, E.5    Comoglio, P.M.6
  • 65
    • 10844223660 scopus 로고    scopus 로고
    • Insulin and its receptor: structure, function and evolution
    • De Meyts P. Insulin and its receptor: structure, function and evolution. Bioessays (2004) 26:1351-62. doi: 10.1002/bies.20151
    • (2004) Bioessays , vol.26 , pp. 1351-1362
    • De Meyts, P.1
  • 66
    • 0038697632 scopus 로고    scopus 로고
    • How to make tubes: signaling by the Met receptor tyrosine kinase
    • Rosario M, Birchmeier W. How to make tubes: signaling by the Met receptor tyrosine kinase. Trends Cell Biol. (2003) 13:328-35. doi: 10.1016/S0962-8924(03)00104-1
    • (2003) Trends Cell Biol , vol.13 , pp. 328-335
    • Rosario, M.1    Birchmeier, W.2
  • 70
    • 33645860514 scopus 로고    scopus 로고
    • Islet endothelial cells and pancreatic beta-cell proliferation: studies in vitro and during pregnancy in adult rats
    • Johansson M, Mattsson G, Andersson A, Jansson L, Carlsson PO. Islet endothelial cells and pancreatic beta-cell proliferation: studies in vitro and during pregnancy in adult rats. Endocrinology (2006) 147:2315-24. doi: 10.1210/en.2005-0997
    • (2006) Endocrinology , vol.147 , pp. 2315-2324
    • Johansson, M.1    Mattsson, G.2    Andersson, A.3    Jansson, L.4    Carlsson, P.O.5
  • 71
    • 33746051766 scopus 로고    scopus 로고
    • Metabolic syndrome in the acute care setting
    • Selig PM. Metabolic syndrome in the acute care setting. AACN Clin Issues (2006) 17:79-85
    • (2006) AACN Clin Issues , vol.17 , pp. 79-85
    • Selig, P.M.1
  • 72
    • 0029549107 scopus 로고
    • Hepatocyte growth factor and acute phase proteins in patients with chronic liver diseases
    • Shiota G, Umeki K, Okano J, Kawasaki H. Hepatocyte growth factor and acute phase proteins in patients with chronic liver diseases. J Med. (1995) 26:295-308
    • (1995) J Med , vol.26 , pp. 295-308
    • Shiota, G.1    Umeki, K.2    Okano, J.3    Kawasaki, H.4
  • 73
    • 0037382786 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome
    • Marchesini G, Bugianesi E, Forlani G, Cerrelli F, Lenzi M, Manini R, et al. Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome. Hepatology (2003) 37:917-23. doi: 10.1053/jhep.2003.50161
    • (2003) Hepatology , vol.37 , pp. 917-923
    • Marchesini, G.1    Bugianesi, E.2    Forlani, G.3    Cerrelli, F.4    Lenzi, M.5    Manini, R.6
  • 74
    • 0034890103 scopus 로고    scopus 로고
    • Physiological role of adipose tissue: white adipose tissue as an endocrine and secretory organ
    • Trayhurn P, Beattie JH. Physiological role of adipose tissue: white adipose tissue as an endocrine and secretory organ. Proc Nutr Soc. (2001) 60:329-39
    • (2001) Proc Nutr Soc , vol.60 , pp. 329-339
    • Trayhurn, P.1    Beattie, J.H.2
  • 76
    • 84958225691 scopus 로고    scopus 로고
    • Circulating level of hepatocyte growth factor predicts incidence of type 2 diabetes mellitus: the Multi-Ethnic Study of Atherosclerosis (MESA)
    • Bancks MP, Bielinski SJ, Decker PA, Hanson NQ, Larson NB, Sicotte H, et al. Circulating level of hepatocyte growth factor predicts incidence of type 2 diabetes mellitus: the Multi-Ethnic Study of Atherosclerosis (MESA). Metabolism (2016) 65:64-72. doi: 10.1016/j.metabol.2015.10.023
    • (2016) Metabolism , vol.65 , pp. 64-72
    • Bancks, M.P.1    Bielinski, S.J.2    Decker, P.A.3    Hanson, N.Q.4    Larson, N.B.5    Sicotte, H.6
  • 77
    • 18244370762 scopus 로고    scopus 로고
    • Inflammation, stress, and diabetes
    • Wellen KE, Hotamisligil GS. Inflammation, stress, and diabetes. J Clin Invest. (2005) 115:1111-9. doi: 10.1172/JCI25102
    • (2005) J Clin Invest , vol.115 , pp. 1111-1119
    • Wellen, K.E.1    Hotamisligil, G.S.2
  • 78
    • 9144223683 scopus 로고    scopus 로고
    • Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
    • Xu H, Barnes GT, Yang Q, Tan G, Yang D, Chou CJ, et al. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest. (2003) 112:1821-30. doi: 10.1172/JCI19451
    • (2003) J Clin Invest , vol.112 , pp. 1821-1830
    • Xu, H.1    Barnes, G.T.2    Yang, Q.3    Tan, G.4    Yang, D.5    Chou, C.J.6
  • 79
    • 0033849777 scopus 로고    scopus 로고
    • Obesity and insulin resistance
    • Kahn BB, Flier JS. Obesity and insulin resistance. J Clin Invest. (2000) 106:473-81. doi: 10.1172/JCI10842
    • (2000) J Clin Invest , vol.106 , pp. 473-481
    • Kahn, B.B.1    Flier, J.S.2
  • 80
    • 1442275317 scopus 로고    scopus 로고
    • Inflammation and activated innate immunity in the pathogenesis of type 2 diabetes
    • Pickup JC. Inflammation and activated innate immunity in the pathogenesis of type 2 diabetes. Diabetes Care (2004) 27:813-23. doi: 10.2337/diacare.27.3.813
    • (2004) Diabetes Care , vol.27 , pp. 813-823
    • Pickup, J.C.1
  • 81
    • 33745216724 scopus 로고    scopus 로고
    • MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity
    • Kanda H, Tateya S, Tamori Y, Kotani K, Hiasa K, Kitazawa R, et al. MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity. J Clin Invest. (2006) 116:1494-505. doi: 10.1172/JCI26498
    • (2006) J Clin Invest , vol.116 , pp. 1494-1505
    • Kanda, H.1    Tateya, S.2    Tamori, Y.3    Kotani, K.4    Hiasa, K.5    Kitazawa, R.6
  • 82
    • 33748750917 scopus 로고    scopus 로고
    • Overexpression of monocyte chemoattractant protein-1 in adipose tissues causes macrophage recruitment and insulin resistance
    • Kamei N, Tobe K, Suzuki R, Ohsugi M, Watanabe T, Kubota N, et al. Overexpression of monocyte chemoattractant protein-1 in adipose tissues causes macrophage recruitment and insulin resistance. J Biol Chem. (2006) 281:26602-14. doi: 10.1074/jbc.M601284200
    • (2006) J Biol Chem , vol.281 , pp. 26602-26614
    • Kamei, N.1    Tobe, K.2    Suzuki, R.3    Ohsugi, M.4    Watanabe, T.5    Kubota, N.6
  • 83
    • 44349161098 scopus 로고    scopus 로고
    • Alternative M2 activation of Kupffer cells by PPARdelta ameliorates obesity-induced insulin resistance
    • Odegaard JI, Ricardo-Gonzalez RR, Red Eagle A, Vats D, Morel CR, Goforth MH, et al. Alternative M2 activation of Kupffer cells by PPARdelta ameliorates obesity-induced insulin resistance. Cell Metab (2008) 7:496-507. doi: 10.1016/j.cmet.2008.04.003
    • (2008) Cell Metab , vol.7 , pp. 496-507
    • Odegaard, J.I.1    Ricardo-Gonzalez, R.R.2    Red Eagle, A.3    Vats, D.4    Morel, C.R.5    Goforth, M.H.6
  • 84
    • 85038569442 scopus 로고    scopus 로고
    • Hepatocyte growth factor prevented high-fat diet-induced obesity and improved insulin resistance in mice
    • Muratsu J, Iwabayashi M, Sanada F, Taniyama Y, Otsu R, Rakugi H, et al. Hepatocyte growth factor prevented high-fat diet-induced obesity and improved insulin resistance in mice. Sci Rep. (2017) 7:130. doi: 10.1038/s41598-017-00199-4
    • (2017) Sci Rep , vol.7 , pp. 130
    • Muratsu, J.1    Iwabayashi, M.2    Sanada, F.3    Taniyama, Y.4    Otsu, R.5    Rakugi, H.6
  • 85
    • 0037464510 scopus 로고    scopus 로고
    • Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults
    • Calle EE, Rodriguez C, Walker-Thurmond K, Thun MJ. Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. N Engl J Med. (2003) 348:1625-38. doi: 10.1056/NEJMoa021423
    • (2003) N Engl J Med , vol.348 , pp. 1625-1638
    • Calle, E.E.1    Rodriguez, C.2    Walker-Thurmond, K.3    Thun, M.J.4
  • 86
    • 75949102926 scopus 로고    scopus 로고
    • Biological mechanisms linking obesity and cancer risk: new perspectives
    • Roberts DL, Dive C, Renehan AG. Biological mechanisms linking obesity and cancer risk: new perspectives. Ann Rev Med. (2010) 61:301-16. doi: 10.1146/annurev.med.080708.082713
    • (2010) Ann Rev Med , vol.61 , pp. 301-316
    • Roberts, D.L.1    Dive, C.2    Renehan, A.G.3
  • 87
    • 67649413362 scopus 로고    scopus 로고
    • Epidemiological and molecular mechanisms aspects linking obesity and cancer
    • Osorio-Costa F, Rocha GZ, Dias MM, Carvalheira JB. Epidemiological and molecular mechanisms aspects linking obesity and cancer. Arq Bras Endocrinol Metabol. (2009) 53:213-26. doi: 10.1590/S0004-27302009000200013
    • (2009) Arq Bras Endocrinol Metabol , vol.53 , pp. 213-226
    • Osorio-Costa, F.1    Rocha, G.Z.2    Dias, M.M.3    Carvalheira, J.B.4
  • 88
    • 63049104211 scopus 로고    scopus 로고
    • Microenvironmental regulation of metastasis
    • Joyce JA, Pollard JW. Microenvironmental regulation of metastasis. Nat Rev Cancer (2009) 9:239-52. doi: 10.1038/nrc2618
    • (2009) Nat Rev Cancer , vol.9 , pp. 239-252
    • Joyce, J.A.1    Pollard, J.W.2
  • 89
    • 84862313154 scopus 로고    scopus 로고
    • Cancer-associated-fibroblasts and tumour cells: a diabolic liaison driving cancer progression
    • Cirri P, Chiarugi P. Cancer-associated-fibroblasts and tumour cells: a diabolic liaison driving cancer progression. Cancer Metast Rev. (2012) 31:195-208. doi: 10.1007/s10555-011-9340-x
    • (2012) Cancer Metast Rev , vol.31 , pp. 195-208
    • Cirri, P.1    Chiarugi, P.2
  • 90
    • 0022891340 scopus 로고
    • Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing
    • Dvorak HF. Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing. N Engl J Med. (1986) 315:1650-9. doi: 10.1056/NEJM198612253152606
    • (1986) N Engl J Med , vol.315 , pp. 1650-1659
    • Dvorak, H.F.1
  • 91
    • 84984694266 scopus 로고    scopus 로고
    • The biology and function of fibroblasts in cancer
    • Kalluri R. The biology and function of fibroblasts in cancer. Nat Rev Cancer (2016) 16:582-98. doi: 10.1038/nrc.2016.73
    • (2016) Nat Rev Cancer , vol.16 , pp. 582-598
    • Kalluri, R.1
  • 93
    • 0025771101 scopus 로고
    • Scatter factor and hepatocyte growth factor are indistinguishable ligands for the MET receptor
    • Naldini L, Weidner KM, Vigna E, Gaudino G, Bardelli A, Ponzetto C, et al. Scatter factor and hepatocyte growth factor are indistinguishable ligands for the MET receptor. EMBO J. (1991) 10:2867-78
    • (1991) EMBO J , vol.10 , pp. 2867-2878
    • Naldini, L.1    Weidner, K.M.2    Vigna, E.3    Gaudino, G.4    Bardelli, A.5    Ponzetto, C.6
  • 94
    • 0023661693 scopus 로고
    • Scatter factor is a fibroblast-derived modulator of epithelial cell mobility
    • Stoker M, Gherardi E, Perryman M, Gray J. Scatter factor is a fibroblast-derived modulator of epithelial cell mobility. Nature (1987) 327:239-42. doi: 10.1038/327239a0
    • (1987) Nature , vol.327 , pp. 239-242
    • Stoker, M.1    Gherardi, E.2    Perryman, M.3    Gray, J.4
  • 95
    • 84997909291 scopus 로고    scopus 로고
    • c-MET as a potential therapeutic target and biomarker in cancer
    • Sierra JR, Tsao MS. c-MET as a potential therapeutic target and biomarker in cancer. Therap Adv Med Oncol. (2011) 3(1 Suppl):S21-35. doi: 10.1177/1758834011422557
    • (2011) Therap Adv Med Oncol , vol.3 , Issue.1 , pp. S21-S35
    • Sierra, J.R.1    Tsao, M.S.2
  • 96
    • 44449151030 scopus 로고    scopus 로고
    • Drug development of MET inhibitors: targeting oncogene addiction and expedience
    • Comoglio PM, Giordano S, Trusolino L. Drug development of MET inhibitors: targeting oncogene addiction and expedience. Nat Rev Drug Discov. (2008) 7:504-16. doi: 10.1038/nrd2530
    • (2008) Nat Rev Drug Discov , vol.7 , pp. 504-516
    • Comoglio, P.M.1    Giordano, S.2    Trusolino, L.3
  • 97
    • 84922923725 scopus 로고    scopus 로고
    • Genomic instability causes HGF gene activation in colon cancer cells, promoting their resistance to necroptosis
    • Seneviratne D, Ma J, Tan X, Kwon YK, Muhammad E, Melhem M, et al. Genomic instability causes HGF gene activation in colon cancer cells, promoting their resistance to necroptosis. Gastroenterology (2015) 148:181-91 e17. doi: 10.1053/j.gastro.2014.09.019
    • (2015) Gastroenterology , vol.148
    • Seneviratne, D.1    Ma, J.2    Tan, X.3    Kwon, Y.K.4    Muhammad, E.5    Melhem, M.6
  • 98
    • 0031858674 scopus 로고    scopus 로고
    • Serum hepatocyte growth factor as an index of disease status of patients with colorectal carcinoma
    • Fukuura T, Miki C, Inoue T, Matsumoto K, Suzuki H. Serum hepatocyte growth factor as an index of disease status of patients with colorectal carcinoma. Br J Cancer (1998) 78:454-9
    • (1998) Br J Cancer , vol.78 , pp. 454-459
    • Fukuura, T.1    Miki, C.2    Inoue, T.3    Matsumoto, K.4    Suzuki, H.5
  • 99
    • 68549118762 scopus 로고    scopus 로고
    • Serum hepatocyte growth factor as a prognostic marker for stage II or III colorectal cancer patients
    • Toiyama Y, Miki C, Inoue Y, Okugawa Y, Tanaka K, Kusunoki M. Serum hepatocyte growth factor as a prognostic marker for stage II or III colorectal cancer patients. Int J Cancer (2009) 125:1657-62. doi: 10.1002/ijc.24554
    • (2009) Int J Cancer , vol.125 , pp. 1657-1662
    • Toiyama, Y.1    Miki, C.2    Inoue, Y.3    Okugawa, Y.4    Tanaka, K.5    Kusunoki, M.6
  • 100
    • 0031899266 scopus 로고    scopus 로고
    • Significance of circulating hepatocyte growth factor level as a prognostic indicator in primary breast cancer
    • Toi M, Taniguchi T, Ueno T, Asano M, Funata N, Sekiguchi K, et al. Significance of circulating hepatocyte growth factor level as a prognostic indicator in primary breast cancer. Clin Cancer Res. (1998) 4:659-64
    • (1998) Clin Cancer Res , vol.4 , pp. 659-664
    • Toi, M.1    Taniguchi, T.2    Ueno, T.3    Asano, M.4    Funata, N.5    Sekiguchi, K.6
  • 102
    • 0032006829 scopus 로고    scopus 로고
    • Elevated serum concentrations of hepatocyte growth factor in patients with multiple myeloma. The Nordic Myeloma Study Group
    • Seidel C, Borset M, Turesson I, Abildgaard N, Sundan A, Waage A. Elevated serum concentrations of hepatocyte growth factor in patients with multiple myeloma. The Nordic Myeloma Study Group. Blood (1998) 91:806-12
    • (1998) Blood , vol.91 , pp. 806-812
    • Seidel, C.1    Borset, M.2    Turesson, I.3    Abildgaard, N.4    Sundan, A.5    Waage, A.6
  • 103
    • 17944362260 scopus 로고    scopus 로고
    • Plasma hepatocyte growth factor is a prognostic factor in patients with acute myeloid leukemia but not in patients with myelodysplastic syndrome
    • Verstovsek S, Kantarjian H, Estey E, Aguayo A, Giles FJ, Manshouri T, et al. Plasma hepatocyte growth factor is a prognostic factor in patients with acute myeloid leukemia but not in patients with myelodysplastic syndrome. Leukemia (2001) 15:1165-70
    • (2001) Leukemia , vol.15 , pp. 1165-1170
    • Verstovsek, S.1    Kantarjian, H.2    Estey, E.3    Aguayo, A.4    Giles, F.J.5    Manshouri, T.6
  • 104
    • 84864285794 scopus 로고    scopus 로고
    • Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion
    • Straussman R, Morikawa T, Shee K, Barzily-Rokni M, Qian ZR, Du J, et al. Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion. Nature (2012) 487:500-4. doi: 10.1038/nature11183
    • (2012) Nature , vol.487 , pp. 500-504
    • Straussman, R.1    Morikawa, T.2    Shee, K.3    Barzily-Rokni, M.4    Qian, Z.R.5    Du, J.6
  • 105
    • 84969888715 scopus 로고    scopus 로고
    • Inhibition of pro-HGF activation by SRI31215, a novel approach to block oncogenic HGF/MET signaling
    • Owusu BY, Bansal N, Venukadasula PK, Ross LJ, Messick TE, Goel S, et al. Inhibition of pro-HGF activation by SRI31215, a novel approach to block oncogenic HGF/MET signaling. Oncotarget (2016) 7:29492-506. doi: 10.18632/oncotarget.8785
    • (2016) Oncotarget , vol.7 , pp. 29492-29506
    • Owusu, B.Y.1    Bansal, N.2    Venukadasula, P.K.3    Ross, L.J.4    Messick, T.E.5    Goel, S.6
  • 106
    • 84956913971 scopus 로고    scopus 로고
    • IKKbeta acts as a tumor suppressor in cancer-associated fibroblasts during intestinal tumorigenesis
    • Pallangyo CK, Ziegler PK, Greten FR. IKKbeta acts as a tumor suppressor in cancer-associated fibroblasts during intestinal tumorigenesis. J Exp Med. (2015) 212:2253-66. doi: 10.1084/jem.20150576
    • (2015) J Exp Med , vol.212 , pp. 2253-2266
    • Pallangyo, C.K.1    Ziegler, P.K.2    Greten, F.R.3
  • 107
    • 84896532797 scopus 로고    scopus 로고
    • MET signaling in colon cancer stem-like cells blunts the therapeutic response to EGFR inhibitors
    • Luraghi P, Reato G, Cipriano E, Sassi F, Orzan F, Bigatto V, et al. MET signaling in colon cancer stem-like cells blunts the therapeutic response to EGFR inhibitors. Cancer Res. (2014) 74:1857-69. doi: 10.1158/0008-5472.CAN-13-2340-T
    • (2014) Cancer Res , vol.74 , pp. 1857-1869
    • Luraghi, P.1    Reato, G.2    Cipriano, E.3    Sassi, F.4    Orzan, F.5    Bigatto, V.6
  • 108
    • 84877114747 scopus 로고    scopus 로고
    • Cancer-associated fibroblasts from hepatocellular carcinoma promote malignant cell proliferation by HGF secretion
    • Jia CC, Wang TT, Liu W, Fu BS, Hua X, Wang GY, et al. Cancer-associated fibroblasts from hepatocellular carcinoma promote malignant cell proliferation by HGF secretion. PLoS ONE (2013) 8:e63243. doi: 10.1371/journal.pone.0063243
    • (2013) PLoS ONE , vol.8
    • Jia, C.C.1    Wang, T.T.2    Liu, W.3    Fu, B.S.4    Hua, X.5    Wang, G.Y.6
  • 109
    • 85114270629 scopus 로고    scopus 로고
    • Role of EMT in metastasis and therapy resistance
    • Smith BN, Bhowmick NA. Role of EMT in metastasis and therapy resistance. J Clin Med. (2016) 5:17. doi: 10.3390/jcm5020017
    • (2016) J Clin Med , vol.5 , pp. 17
    • Smith, B.N.1    Bhowmick, N.A.2
  • 110
    • 84938099381 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition and drug resistance in breast cancer (Review)
    • Huang J, Li H, Ren G. Epithelial-mesenchymal transition and drug resistance in breast cancer (Review). Int J Oncol. (2015) 47:840-8. doi: 10.3892/ijo.2015.3084
    • (2015) Int J Oncol , vol.47 , pp. 840-848
    • Huang, J.1    Li, H.2    Ren, G.3
  • 111
    • 85029804762 scopus 로고    scopus 로고
    • Targeting the tumor-promoting microenvironment in MET-amplified NSCLC cells with a novel inhibitor of pro-HGF activation
    • Owusu BY, Thomas S, Venukadasula P, Han Z, Janetka JW, Galemmo RA Jr., et al. Targeting the tumor-promoting microenvironment in MET-amplified NSCLC cells with a novel inhibitor of pro-HGF activation. Oncotarget (2017) 8:63014-25. doi: 10.18632/oncotarget.18260
    • (2017) Oncotarget , vol.8 , pp. 63014-63025
    • Owusu, B.Y.1    Thomas, S.2    Venukadasula, P.3    Han, Z.4    Janetka, J.W.5    Jr Galemmo, R.A.6
  • 112
    • 84885735554 scopus 로고    scopus 로고
    • Mutational landscape and significance across 12 major cancer types
    • Kandoth C, McLellan MD, Vandin F, Ye K, Niu B, Lu C, et al. Mutational landscape and significance across 12 major cancer types. Nature (2013) 502:333-9. doi: 10.1038/nature12634
    • (2013) Nature , vol.502 , pp. 333-339
    • Kandoth, C.1    McLellan, M.D.2    Vandin, F.3    Ye, K.4    Niu, B.5    Lu, C.6
  • 114
    • 84962699438 scopus 로고    scopus 로고
    • MET inhibition overcomes radiation resistance of glioblastoma stem-like cells
    • De Bacco F, D'Ambrosio A, Casanova E, Orzan F, Neggia R, Albano R, et al. MET inhibition overcomes radiation resistance of glioblastoma stem-like cells. EMBO Mol Med. (2016) 8:550-68. doi: 10.15252/emmm.201505890
    • (2016) EMBO Mol Med , vol.8 , pp. 550-568
    • De Bacco, F.1    D'Ambrosio, A.2    Casanova, E.3    Orzan, F.4    Neggia, R.5    Albano, R.6
  • 115
    • 84878540077 scopus 로고    scopus 로고
    • The MET oncogene in glioblastoma stem cells: implications as a diagnostic marker and a therapeutic target
    • Boccaccio C, Comoglio PM. The MET oncogene in glioblastoma stem cells: implications as a diagnostic marker and a therapeutic target. Cancer Res. (2013) 73:3193-9. doi: 10.1158/0008-5472.CAN-12-4039
    • (2013) Cancer Res , vol.73 , pp. 3193-3199
    • Boccaccio, C.1    Comoglio, P.M.2
  • 116
    • 84917691199 scopus 로고    scopus 로고
    • Targeting the c-Met/FZD8 signaling axis eliminates patient-derived cancer stem-like cells in head and neck squamous carcinomas
    • Sun S, Liu S, Duan SZ, Zhang L, Zhou H, Hu Y, et al. Targeting the c-Met/FZD8 signaling axis eliminates patient-derived cancer stem-like cells in head and neck squamous carcinomas. Cancer Res. (2014) 74:7546-59. doi: 10.1158/0008-5472.CAN-14-0826
    • (2014) Cancer Res , vol.74 , pp. 7546-7559
    • Sun, S.1    Liu, S.2    Duan, S.Z.3    Zhang, L.4    Zhou, H.5    Hu, Y.6
  • 118
    • 81855194258 scopus 로고    scopus 로고
    • c-Met is a marker of pancreatic cancer stem cells and therapeutic target
    • Li C, Wu JJ, Hynes M, Dosch J, Sarkar B, Welling TH, et al. c-Met is a marker of pancreatic cancer stem cells and therapeutic target. Gastroenterology (2011) 141:2218-27 e5. doi: 10.1053/j.gastro.2011.08.009
    • (2011) Gastroenterology , vol.141
    • Li, C.1    Wu, J.J.2    Hynes, M.3    Dosch, J.4    Sarkar, B.5    Welling, T.H.6
  • 119
    • 84937522427 scopus 로고    scopus 로고
    • Hepatokines: unlocking the multi-organ network in metabolic diseases
    • Iroz A, Couty JP, Postic C. Hepatokines: unlocking the multi-organ network in metabolic diseases. Diabetologia (2015) 58:1699-703. doi: 10.1007/s00125-015-3634-4
    • (2015) Diabetologia , vol.58 , pp. 1699-1703
    • Iroz, A.1    Couty, J.P.2    Postic, C.3


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