메뉴 건너뛰기




Volumn 13, Issue 9, 2017, Pages 509-520

Hepatokines: Linking nonalcoholic fatty liver disease and insulin resistance

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOPOIETIN; ANGIOPOIETIN 4; CELL PROTEIN; CYCLIC AMP DEPENDENT PROTEIN KINASE; FATTY ACID; FETUIN A; FETUIN B; FIBROBLAST GROWTH FACTOR 21; GLUCOSE; HEPASSOCIN; HEPATOKINES; LIVER PROTEIN; PHOSPHOPROTEIN PHOSPHATASE 2A; PROTEIN KINASE C EPSILON; PROTEIN LECT2; RETINOL BINDING PROTEIN 4; SELENOPROTEIN P; SEX HORMONE BINDING PROTEIN; TRANSCRIPTION FACTOR FKHR; TRIACYLGLYCEROL LIPASE; UNCLASSIFIED DRUG; PLASMA PROTEIN; PLASMA RETINOL BINDING PROTEIN; RBP4 PROTEIN, HUMAN;

EID: 85028589380     PISSN: 17595029     EISSN: 17595037     Source Type: Journal    
DOI: 10.1038/nrendo.2017.56     Document Type: Review
Times cited : (462)

References (100)
  • 1
    • 20044374023 scopus 로고    scopus 로고
    • Design and validation of a histological scoring system for nonalcoholic fatty liver disease
    • Kleiner, D. E., et al. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology 41, 1313-1321 (2005).
    • (2005) Hepatology , vol.41 , pp. 1313-1321
    • Kleiner, D.E.1
  • 2
    • 84976479130 scopus 로고    scopus 로고
    • Global epidemiology of nonalcoholic fatty liver disease-meta-analytic assessment of prevalence, incidence, and outcomes
    • Younossi, Z. M., et al. Global epidemiology of nonalcoholic fatty liver disease-meta-analytic assessment of prevalence, incidence, and outcomes. Hepatology 64, 73-84 (2016).
    • (2016) Hepatology , vol.64 , pp. 73-84
    • Younossi, Z.M.1
  • 3
    • 10644220306 scopus 로고    scopus 로고
    • Prevalence of hepatic steatosis in an urban population in the United States: Impact of ethnicity
    • Browning, J. D., et al. Prevalence of hepatic steatosis in an urban population in the United States: Impact of ethnicity. Hepatology 40, 1387-1395 (2004).
    • (2004) Hepatology , vol.40 , pp. 1387-1395
    • Browning, J.D.1
  • 4
    • 0033982172 scopus 로고    scopus 로고
    • Prevalence of and risk factors for hepatic steatosis in Northern Italy
    • Bellentani, S., et al. Prevalence of and risk factors for hepatic steatosis in Northern Italy. Ann. Intern. Med. 132, 112-117 (2000).
    • (2000) Ann. Intern. Med. , vol.132 , pp. 112-117
    • Bellentani, S.1
  • 5
    • 0031913573 scopus 로고    scopus 로고
    • Liver abnormalities in severely obese subjects: Effect of drastic weight loss after gastroplasty
    • Luyckx, F. H., et al. Liver abnormalities in severely obese subjects: Effect of drastic weight loss after gastroplasty. Int. J. Obes. Relat. Metab. Disord. 22, 222-226 (1998).
    • (1998) Int. J. Obes. Relat. Metab. Disord. , vol.22 , pp. 222-226
    • Luyckx, F.H.1
  • 6
    • 0025002079 scopus 로고
    • Liver pathology in morbidly obese patients with and without diabetes
    • Silverman, J. F., et al. Liver pathology in morbidly obese patients with and without diabetes. Am. J. Gastroenterol. 85, 1349-1355 (1990).
    • (1990) Am. J. Gastroenterol. , vol.85 , pp. 1349-1355
    • Silverman, J.F.1
  • 7
    • 57749183469 scopus 로고    scopus 로고
    • Prevalence and associated factors of non-alcoholic fatty liver disease in patients with type-2 diabetes mellitus
    • Leite, N. C., Salles, G. F., Araujo, A. L., Villela-Nogueira, C. A. & Cardoso, C. R. Prevalence and associated factors of non-alcoholic fatty liver disease in patients with type-2 diabetes mellitus. Liver Int. 29, 113-119 (2009).
    • (2009) Liver Int. , vol.29 , pp. 113-119
    • Leite, N.C.1    Salles, G.F.2    Araujo, A.L.3    Villela-Nogueira, C.A.4    Cardoso, C.R.5
  • 8
    • 0019152816 scopus 로고
    • Nonalcoholic steatohepatitis: Mayo Clinic experiences with a hitherto unnamed disease
    • Ludwig, J., Viggiano, T. R., McGill, D. B. & Oh, B. J. Nonalcoholic steatohepatitis: Mayo Clinic experiences with a hitherto unnamed disease. Mayo Clin. Proc. 55, 434-438 (1980).
    • (1980) Mayo Clin. Proc. , vol.55 , pp. 434-438
    • Ludwig, J.1    Viggiano, T.R.2    McGill, D.B.3    Oh, B.J.4
  • 9
    • 84862082712 scopus 로고    scopus 로고
    • Metabolic consequences of hepatic steatosis in overweight and obese adolescents
    • Wicklow, B. A., et al. Metabolic consequences of hepatic steatosis in overweight and obese adolescents. Diabetes Care 35, 905-910 (2012).
    • (2012) Diabetes Care , vol.35 , pp. 905-910
    • Wicklow, B.A.1
  • 10
    • 84923239473 scopus 로고    scopus 로고
    • Hepatokines as a link between obesity and cardiovascular diseases
    • Yoo, H. J. & Choi, K. M. Hepatokines as a link between obesity and cardiovascular diseases. Diabetes Metab. J. 39, 10-15 (2015).
    • (2015) Diabetes Metab. J. , vol.39 , pp. 10-15
    • Yoo, H.J.1    Choi, K.M.2
  • 11
    • 84884508163 scopus 로고    scopus 로고
    • A systematic review: Burden and severity of subclinical cardiovascular disease among those with nonalcoholic fatty liver; Should we care
    • Oni, E. T., et al. A systematic review: Burden and severity of subclinical cardiovascular disease among those with nonalcoholic fatty liver; should we care Atherosclerosis 230, 258-267 (2013).
    • (2013) Atherosclerosis , vol.230 , pp. 258-267
    • Oni, E.T.1
  • 12
    • 50549084740 scopus 로고    scopus 로고
    • Increased overall mortality and liver-related mortality in non-alcoholic fatty liver disease
    • Ong, J. P., Pitts, A. & Younossi, Z. M. Increased overall mortality and liver-related mortality in non-alcoholic fatty liver disease. J. Hepatol. 49, 608-612 (2008).
    • (2008) J. Hepatol. , vol.49 , pp. 608-612
    • Ong, J.P.1    Pitts, A.2    Younossi, Z.M.3
  • 13
    • 79961235988 scopus 로고    scopus 로고
    • Serum selenoprotein P levels in patients with type 2 diabetes and prediabetes: Implications for insulin resistance, inflammation, and atherosclerosis
    • Yang, S. J., et al. Serum selenoprotein P levels in patients with type 2 diabetes and prediabetes: Implications for insulin resistance, inflammation, and atherosclerosis. J. Clin. Endocrinol. Metab. 96, E1325-E1329 (2011).
    • (2011) J. Clin. Endocrinol. Metab. , vol.96 , pp. E1325-E1329
    • Yang, S.J.1
  • 14
    • 52049125433 scopus 로고    scopus 로고
    • Sex hormones, sex hormone binding globulin, and abdominal aortic calcification in women and men in the multi-ethnic study of atherosclerosis (MESA)
    • Michos, E. D., et al. Sex hormones, sex hormone binding globulin, and abdominal aortic calcification in women and men in the multi-ethnic study of atherosclerosis (MESA). Atherosclerosis 200, 432-438 (2008).
    • (2008) Atherosclerosis , vol.200 , pp. 432-438
    • Michos, E.D.1
  • 15
    • 85003758672 scopus 로고    scopus 로고
    • Association between serum fibroblast growth factor 21 and mortality among patients with coronary artery disease
    • Li, Q., et al. Association between serum fibroblast growth factor 21 and mortality among patients with coronary artery disease. J. Clin. Endocrinol. Metab. 101, 4886-4894 (2016).
    • (2016) J. Clin. Endocrinol. Metab. , vol.101 , pp. 4886-4894
    • Li, Q.1
  • 16
    • 84942197808 scopus 로고    scopus 로고
    • Serum adropin level in patients with stable coronary artery disease
    • Zhao, L. P., et al. Serum adropin level in patients with stable coronary artery disease. Heart Lung Circ. 24, 975-979 (2015).
    • (2015) Heart Lung Circ. , vol.24 , pp. 975-979
    • Zhao, L.P.1
  • 17
    • 84906882822 scopus 로고    scopus 로고
    • Global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013: A systematic analysis for the Global Burden of Disease Study 2013
    • Ng, M., et al. Global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013: A systematic analysis for the Global Burden of Disease Study 2013. Lancet 384, 766-781 (2014).
    • (2014) Lancet , vol.384 , pp. 766-781
    • Ng, M.1
  • 18
    • 18244382304 scopus 로고    scopus 로고
    • Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease
    • Donnelly, K. L., et al. Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease. J. Clin. Invest. 115, 1343-1351 (2005).
    • (2005) J. Clin. Invest. , vol.115 , pp. 1343-1351
    • Donnelly, K.L.1
  • 19
    • 84899489259 scopus 로고    scopus 로고
    • Lipolysis in lipid turnover, cancer cachexia, and obesity-induced insulin resistance
    • Arner, P. & Langin, D. Lipolysis in lipid turnover, cancer cachexia, and obesity-induced insulin resistance. Trends Endocrinol. Metab. 25, 255-262 (2014).
    • (2014) Trends Endocrinol. Metab. , vol.25 , pp. 255-262
    • Arner, P.1    Langin, D.2
  • 20
    • 0025257224 scopus 로고
    • Insulin regulation of glucose and lipid metabolism in massive obesity
    • Del Prato, S., et al. Insulin regulation of glucose and lipid metabolism in massive obesity. Diabetologia 33, 228-236 (1990).
    • (1990) Diabetologia , vol.33 , pp. 228-236
    • Del Prato, S.1
  • 21
    • 38649111018 scopus 로고    scopus 로고
    • Alterations in adipose tissue and hepatic lipid kinetics in obese men and women with nonalcoholic fatty liver disease
    • Fabbrini, E., et al. Alterations in adipose tissue and hepatic lipid kinetics in obese men and women with nonalcoholic fatty liver disease. Gastroenterology 134, 424-431 (2008).
    • (2008) Gastroenterology , vol.134 , pp. 424-431
    • Fabbrini, E.1
  • 22
    • 33845348168 scopus 로고    scopus 로고
    • Alterations in regulation of energy homeostasis in cyclic nucleotide phosphodiesterase 3B-null mice
    • Choi, Y. H., et al. Alterations in regulation of energy homeostasis in cyclic nucleotide phosphodiesterase 3B-null mice. J. Clin. Invest. 116, 3240-3251 (2006).
    • (2006) J. Clin. Invest. , vol.116 , pp. 3240-3251
    • Choi, Y.H.1
  • 23
    • 84865420340 scopus 로고    scopus 로고
    • Identification and functional characterization of protein kinase A phosphorylation sites in the major lipolytic protein, adipose triglyceride lipase
    • Pagnon, J., et al. Identification and functional characterization of protein kinase A phosphorylation sites in the major lipolytic protein, adipose triglyceride lipase. Endocrinology 153, 4278-4289 (2012).
    • (2012) Endocrinology , vol.153 , pp. 4278-4289
    • Pagnon, J.1
  • 24
    • 67649403606 scopus 로고    scopus 로고
    • FoxO1 controls insulin-dependent adipose triglyceride lipase (ATGL) expression and lipolysis in adipocytes
    • Chakrabarti, P. & Kandror, K. V. FoxO1 controls insulin-dependent adipose triglyceride lipase (ATGL) expression and lipolysis in adipocytes. J. Biol. Chem. 284, 13296-13300 (2009).
    • (2009) J. Biol. Chem. , vol.284 , pp. 13296-13300
    • Chakrabarti, P.1    Kandror, K.V.2
  • 25
    • 84919609004 scopus 로고    scopus 로고
    • Proton magnetic resonance spectroscopy reveals increased hepatic lipid content after a single high-fat meal with no additional modulation by added protein
    • Lindeboom, L., et al. Proton magnetic resonance spectroscopy reveals increased hepatic lipid content after a single high-fat meal with no additional modulation by added protein. Am. J. Clin. Nutr. 101, 65-71 (2015).
    • (2015) Am. J. Clin. Nutr. , vol.101 , pp. 65-71
    • Lindeboom, L.1
  • 26
    • 84878871217 scopus 로고    scopus 로고
    • Distinct patterns of tissue-specific lipid accumulation during the induction of insulin resistance in mice by high-fat feeding
    • Turner, N., et al. Distinct patterns of tissue-specific lipid accumulation during the induction of insulin resistance in mice by high-fat feeding. Diabetologia 56, 1638-1648 (2013).
    • (2013) Diabetologia , vol.56 , pp. 1638-1648
    • Turner, N.1
  • 27
    • 79953905691 scopus 로고    scopus 로고
    • Three weeks on a high-fat diet increases intrahepatic lipid accumulation and decreases metabolic flexibility in healthy overweight men
    • van Herpen, N. A., Schrauwen-Hinderling, V. B., Schaart, G., Mensink, R. P. & Schrauwen, P. Three weeks on a high-fat diet increases intrahepatic lipid accumulation and decreases metabolic flexibility in healthy overweight men. J. Clin. Endocrinol. Metab. 96, E691-E695 (2011).
    • (2011) J. Clin. Endocrinol. Metab. , vol.96 , pp. E691-E695
    • Van Herpen, N.A.1    Schrauwen-Hinderling, V.B.2    Schaart, G.3    Mensink, R.P.4    Schrauwen, P.5
  • 28
    • 0017189350 scopus 로고
    • Lipid composition of plasma obtained from various parts of the vascular system of the rabbit
    • Madry, K., Lut, W., Lepert, R., Borkowska, M. & Papiernik, E. Lipid composition of plasma obtained from various parts of the vascular system of the rabbit. Acta Physiol. Pol. 27, 485-492 (1976).
    • (1976) Acta Physiol. Pol. , vol.27 , pp. 485-492
    • Madry, K.1    Lut, W.2    Lepert, R.3    Borkowska, M.4    Papiernik, E.5
  • 29
    • 85055597575 scopus 로고    scopus 로고
    • Quantum coherence spectroscopy to measure dietary fat retention in the liver
    • Lindeboom, L., et al. Quantum coherence spectroscopy to measure dietary fat retention in the liver. JCI Insight 1, e84671 (2016).
    • (2016) JCI Insight , vol.1 , pp. e84671
    • Lindeboom, L.1
  • 30
    • 79959517565 scopus 로고    scopus 로고
    • Human fatty liver disease: Old questions and new insights
    • Cohen, J. C., Horton, J. D. & Hobbs, H. H. Human fatty liver disease: Old questions and new insights. Science 332, 1519-1523 (2011).
    • (2011) Science , vol.332 , pp. 1519-1523
    • Cohen, J.C.1    Horton, J.D.2    Hobbs, H.H.3
  • 31
    • 0029846701 scopus 로고    scopus 로고
    • Regulation of hepatic de novo lipogenesis in humans
    • Hellerstein, M. K., Schwarz, J. M. & Neese, R. A. Regulation of hepatic de novo lipogenesis in humans. Annu. Rev. Nutr. 16, 523-557 (1996).
    • (1996) Annu. Rev. Nutr. , vol.16 , pp. 523-557
    • Hellerstein, M.K.1    Schwarz, J.M.2    Neese, R.A.3
  • 33
    • 0036251153 scopus 로고    scopus 로고
    • SREBPs: Activators of the complete program of cholesterol and fatty acid synthesis in the liver
    • Horton, J. D., Goldstein, J. L. & Brown, M. S. SREBPs: Activators of the complete program of cholesterol and fatty acid synthesis in the liver. J. Clin. Invest. 109, 1125-1131 (2002).
    • (2002) J. Clin. Invest. , vol.109 , pp. 1125-1131
    • Horton, J.D.1    Goldstein, J.L.2    Brown, M.S.3
  • 34
    • 0037098291 scopus 로고    scopus 로고
    • Carbohydrate responsive element-binding protein (ChREBP): A key regulator of glucose metabolism and fat storage
    • Uyeda, K., Yamashita, H. & Kawaguchi, T. Carbohydrate responsive element-binding protein (ChREBP): A key regulator of glucose metabolism and fat storage. Biochem. Pharmacol. 63, 2075-2080 (2002).
    • (2002) Biochem. Pharmacol. , vol.63 , pp. 2075-2080
    • Uyeda, K.1    Yamashita, H.2    Kawaguchi, T.3
  • 35
    • 13744263104 scopus 로고    scopus 로고
    • Temporal pattern of de novo lipogenesis in the postprandial state in healthy men
    • Timlin, M. T. & Parks, E. J. Temporal pattern of de novo lipogenesis in the postprandial state in healthy men. Am. J. Clin. Nutr. 81, 35-42 (2005).
    • (2005) Am. J. Clin. Nutr. , vol.81 , pp. 35-42
    • Timlin, M.T.1    Parks, E.J.2
  • 36
    • 84863707554 scopus 로고    scopus 로고
    • Mitochondrial roles and cytoprotection in chronic liver injury
    • Degli Esposti, D., et al. Mitochondrial roles and cytoprotection in chronic liver injury. Biochem. Res. Int. 2012, 387626 (2012).
    • (2012) Biochem. Res. Int. , vol.2012 , pp. 387626
    • Degli Esposti, D.1
  • 37
    • 77951632831 scopus 로고    scopus 로고
    • Mitochondrial dysfunction precedes insulin resistance and hepatic steatosis and contributes to the natural history of non-alcoholic fatty liver disease in an obese rodent model
    • Rector, R. S., et al. Mitochondrial dysfunction precedes insulin resistance and hepatic steatosis and contributes to the natural history of non-alcoholic fatty liver disease in an obese rodent model. J. Hepatol. 52, 727-736 (2010).
    • (2010) J. Hepatol. , vol.52 , pp. 727-736
    • Rector, R.S.1
  • 38
    • 70350043496 scopus 로고    scopus 로고
    • Abnormal hepatic energy homeostasis in type 2 diabetes
    • Szendroedi, J., et al. Abnormal hepatic energy homeostasis in type 2 diabetes. Hepatology 50, 1079-1086 (2009).
    • (2009) Hepatology , vol.50 , pp. 1079-1086
    • Szendroedi, J.1
  • 39
    • 21044438592 scopus 로고    scopus 로고
    • Mice heterozygous for a defect in mitochondrial trifunctional protein develop hepatic steatosis and insulin resistance
    • Ibdah, J. A., et al. Mice heterozygous for a defect in mitochondrial trifunctional protein develop hepatic steatosis and insulin resistance. Gastroenterology 128, 1381-1390 (2005).
    • (2005) Gastroenterology , vol.128 , pp. 1381-1390
    • Ibdah, J.A.1
  • 40
    • 84943227450 scopus 로고    scopus 로고
    • Quercetin reduces obesity-induced hepatosteatosis by enhancing mitochondrial oxidative metabolism via heme oxygenase-1
    • Kim, C. S., et al. Quercetin reduces obesity-induced hepatosteatosis by enhancing mitochondrial oxidative metabolism via heme oxygenase-1. Nutr. Metab. (Lond.) 12, 33 (2015).
    • (2015) Nutr. Metab. (Lond.) , vol.12 , pp. 33
    • Kim, C.S.1
  • 41
    • 37549067407 scopus 로고    scopus 로고
    • Fenofibrate modulates cardiac and hepatic metabolism and increases ischemic tolerance in diet-induced obese mice
    • Aasum, E., et al. Fenofibrate modulates cardiac and hepatic metabolism and increases ischemic tolerance in diet-induced obese mice. J. Mol. Cell. Cardiol. 44, 201-209 (2008).
    • (2008) J. Mol. Cell. Cardiol. , vol.44 , pp. 201-209
    • Aasum, E.1
  • 42
    • 84994860563 scopus 로고    scopus 로고
    • Statins increase mitochondrial and peroxisomal fatty acid oxidation in the liver and prevent non-alcoholic steatohepatitis in mice
    • Park, H. S., et al. Statins increase mitochondrial and peroxisomal fatty acid oxidation in the liver and prevent non-alcoholic steatohepatitis in mice. Diabetes Metab. J. 40, 376-385 (2016).
    • (2016) Diabetes Metab. J. , vol.40 , pp. 376-385
    • Park, H.S.1
  • 43
    • 0036788329 scopus 로고    scopus 로고
    • Impaired adaptive resynthesis and prolonged depletion of hepatic mitochondrial DNA after repeated alcohol binges in mice
    • Demeilliers, C., et al. Impaired adaptive resynthesis and prolonged depletion of hepatic mitochondrial DNA after repeated alcohol binges in mice. Gastroenterology 123, 1278-1290 (2002).
    • (2002) Gastroenterology , vol.123 , pp. 1278-1290
    • Demeilliers, C.1
  • 44
    • 79955473343 scopus 로고    scopus 로고
    • Increased mitochondrial oxidative phosphorylation in the liver is associated with obesity and insulin resistance
    • Buchner, D. A., et al. Increased mitochondrial oxidative phosphorylation in the liver is associated with obesity and insulin resistance. Obesity (Silver Spring) 19, 917-924 (2011).
    • (2011) Obesity (Silver Spring) , vol.19 , pp. 917-924
    • Buchner, D.A.1
  • 45
    • 84937738375 scopus 로고    scopus 로고
    • Adaptation of hepatic mitochondrial function in humans with non-alcoholic fatty liver is lost in steatohepatitis
    • Koliaki, C., et al. Adaptation of hepatic mitochondrial function in humans with non-alcoholic fatty liver is lost in steatohepatitis. Cell Metab. 21, 739-746 (2015).
    • (2015) Cell Metab. , vol.21 , pp. 739-746
    • Koliaki, C.1
  • 46
    • 82955239838 scopus 로고    scopus 로고
    • Excessive hepatic mitochondrial TCA cycle and gluconeogenesis in humans with nonalcoholic fatty liver disease
    • Sunny, N. E., Parks, E. J., Browning, J. D. & Burgess, S. C. Excessive hepatic mitochondrial TCA cycle and gluconeogenesis in humans with nonalcoholic fatty liver disease. Cell Metab. 14, 804-810 (2011).
    • (2011) Cell Metab. , vol.14 , pp. 804-810
    • Sunny, N.E.1    Parks, E.J.2    Browning, J.D.3    Burgess, S.C.4
  • 47
    • 84945321040 scopus 로고    scopus 로고
    • Genetics of nonalcoholic fatty liver disease
    • Dongiovanni, P. & Valenti, L. Genetics of nonalcoholic fatty liver disease. Metabolism 65, 1026-1037 (2016).
    • (2016) Metabolism , vol.65 , pp. 1026-1037
    • Dongiovanni, P.1    Valenti, L.2
  • 48
    • 0037244002 scopus 로고    scopus 로고
    • Microsomal triglyceride transfer protein and its role in apoB-lipoprotein assembly
    • Hussain, M. M., Shi, J. & Dreizen, P. Microsomal triglyceride transfer protein and its role in apoB-lipoprotein assembly. J. Lipid Res. 44, 22-32 (2003).
    • (2003) J. Lipid Res. , vol.44 , pp. 22-32
    • Hussain, M.M.1    Shi, J.2    Dreizen, P.3
  • 49
    • 0034693047 scopus 로고    scopus 로고
    • A targeted apolipoprotein B-38.9-producing mutation causes fatty livers in mice due to the reduced ability of apolipoprotein B-38.9 to transport triglycerides
    • Chen, Z., Fitzgerald, R. L., Averna, M. R. & Schonfeld, G. A targeted apolipoprotein B-38.9-producing mutation causes fatty livers in mice due to the reduced ability of apolipoprotein B-38.9 to transport triglycerides. J. Biol. Chem. 275, 32807-32815 (2000).
    • (2000) J. Biol. Chem. , vol.275 , pp. 32807-32815
    • Chen, Z.1    Fitzgerald, R.L.2    Averna, M.R.3    Schonfeld, G.4
  • 50
    • 84881025772 scopus 로고    scopus 로고
    • A novel APOB mutation identified by exome sequencing cosegregates with steatosis, liver cancer, and hypocholesterolemia
    • Cefalu, A. B., et al. A novel APOB mutation identified by exome sequencing cosegregates with steatosis, liver cancer, and hypocholesterolemia. Arterioscler. Thromb. Vasc. Biol. 33, 2021-2025 (2013).
    • (2013) Arterioscler. Thromb. Vasc. Biol. , vol.33 , pp. 2021-2025
    • Cefalu, A.B.1
  • 51
    • 84944061167 scopus 로고    scopus 로고
    • MTTP-297H polymorphism reduced serum cholesterol but increased risk of non-alcoholic fatty liver disease-a cross-sectional study
    • Hsiao, P. J., et al. MTTP-297H polymorphism reduced serum cholesterol but increased risk of non-alcoholic fatty liver disease-a cross-sectional study. BMC Med. Genet. 16, 93 (2015).
    • (2015) BMC Med. Genet. , vol.16 , pp. 93
    • Hsiao, P.J.1
  • 52
    • 33644700376 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease and risk of future cardiovascular events among type 2 diabetic patients
    • Targher, G., et al. Nonalcoholic fatty liver disease and risk of future cardiovascular events among type 2 diabetic patients. Diabetes 54, 3541-3546 (2005).
    • (2005) Diabetes , vol.54 , pp. 3541-3546
    • Targher, G.1
  • 53
    • 84883778461 scopus 로고    scopus 로고
    • MRI measurement of liver fat content predicts the metabolic syndrome
    • Ducluzeau, P. H., et al. MRI measurement of liver fat content predicts the metabolic syndrome. Diabetes Metab. 39, 314-321 (2013).
    • (2013) Diabetes Metab. , vol.39 , pp. 314-321
    • Ducluzeau, P.H.1
  • 54
    • 84879841596 scopus 로고    scopus 로고
    • Fatty liver score and 15-year incidence of type 2 diabetes
    • Kotronen, A., et al. Fatty liver score and 15-year incidence of type 2 diabetes. Hepatol. Int. 7, 610-621 (2013).
    • (2013) Hepatol. Int. , vol.7 , pp. 610-621
    • Kotronen, A.1
  • 55
    • 84876105171 scopus 로고    scopus 로고
    • Clinical availability of nonalcoholic fatty liver disease as an early predictor of type 2 diabetes mellitus in Korean men: 5-year prospective cohort study
    • Park, S. K., Seo, M. H., Shin, H. C. & Ryoo, J. H. Clinical availability of nonalcoholic fatty liver disease as an early predictor of type 2 diabetes mellitus in Korean men: 5-year prospective cohort study. Hepatology 57, 1378-1383 (2013).
    • (2013) Hepatology , vol.57 , pp. 1378-1383
    • Park, S.K.1    Seo, M.H.2    Shin, H.C.3    Ryoo, J.H.4
  • 56
    • 84883763886 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease independently predicts prediabetes during a 7-year prospective follow-up
    • Zelber-Sagi, S., et al. Non-alcoholic fatty liver disease independently predicts prediabetes during a 7-year prospective follow-up. Liver Int. 33, 1406-1412 (2013).
    • (2013) Liver Int. , vol.33 , pp. 1406-1412
    • Zelber-Sagi, S.1
  • 57
    • 84864007967 scopus 로고    scopus 로고
    • Global variability in diabetes mellitus and its association with body weight and primary healthcare support in 49 low-A nd middle-income developing countries
    • Liu, L., Yin, X. & Morrissey, S. Global variability in diabetes mellitus and its association with body weight and primary healthcare support in 49 low-A nd middle-income developing countries. Diabet. Med. 29, 995-1002 (2012).
    • (2012) Diabet. Med. , vol.29 , pp. 995-1002
    • Liu, L.1    Yin, X.2    Morrissey, S.3
  • 58
    • 0035487317 scopus 로고    scopus 로고
    • Intramyocellular lipid is associated with resistance to in vivo insulin actions on glucose uptake, antilipolysis, and early insulin signaling pathways in human skeletal muscle
    • Virkamaki, A., et al. Intramyocellular lipid is associated with resistance to in vivo insulin actions on glucose uptake, antilipolysis, and early insulin signaling pathways in human skeletal muscle. Diabetes 50, 2337-2343 (2001).
    • (2001) Diabetes , vol.50 , pp. 2337-2343
    • Virkamaki, A.1
  • 59
    • 0032934826 scopus 로고    scopus 로고
    • Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: A 1H NMR spectroscopy study
    • Krssak, M., et al. Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: A 1H NMR spectroscopy study. Diabetologia 42, 113-116 (1999).
    • (1999) Diabetologia , vol.42 , pp. 113-116
    • Krssak, M.1
  • 60
    • 0032960890 scopus 로고    scopus 로고
    • Association of increased intramyocellular lipid content with insulin resistance in lean nondiabetic offspring of type 2 diabetic subjects
    • Jacob, S., et al. Association of increased intramyocellular lipid content with insulin resistance in lean nondiabetic offspring of type 2 diabetic subjects. Diabetes 48, 1113-1119 (1999).
    • (1999) Diabetes , vol.48 , pp. 1113-1119
    • Jacob, S.1
  • 61
    • 0030765908 scopus 로고    scopus 로고
    • Subcutaneous abdominal fat and thigh muscle composition predict insulin sensitivity independently of visceral fat
    • Goodpaster, B. H., Thaete, F. L., Simoneau, J. A. & Kelley, D. E. Subcutaneous abdominal fat and thigh muscle composition predict insulin sensitivity independently of visceral fat. Diabetes 46, 1579-1585 (1997).
    • (1997) Diabetes , vol.46 , pp. 1579-1585
    • Goodpaster, B.H.1    Thaete, F.L.2    Simoneau, J.A.3    Kelley, D.E.4
  • 63
    • 0345374579 scopus 로고    scopus 로고
    • Minireview: Weapons of lean body mass destruction: The role of ectopic lipids in the metabolic syndrome
    • Unger, R. H. Minireview: Weapons of lean body mass destruction: The role of ectopic lipids in the metabolic syndrome. Endocrinology 144, 5159-5165 (2003).
    • (2003) Endocrinology , vol.144 , pp. 5159-5165
    • Unger, R.H.1
  • 64
    • 70349326750 scopus 로고    scopus 로고
    • Intrahepatic fat, not visceral fat, is linked with metabolic complications of obesity
    • Fabbrini, E., et al. Intrahepatic fat, not visceral fat, is linked with metabolic complications of obesity. Proc. Natl Acad. Sci. USA 106, 15430-15435 (2009).
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 15430-15435
    • Fabbrini, E.1
  • 65
    • 42949178538 scopus 로고    scopus 로고
    • Liver muscle, and adipose tissue insulin action is directly related to intrahepatic triglyceride content in obese subjects
    • Korenblat, K. M., Fabbrini, E., Mohammed, B. S. & Klein, S. Liver, muscle, and adipose tissue insulin action is directly related to intrahepatic triglyceride content in obese subjects. Gastroenterology 134, 1369-1375 (2008).
    • (2008) Gastroenterology , vol.134 , pp. 1369-1375
    • Korenblat, K.M.1    Fabbrini, E.2    Mohammed, B.S.3    Klein, S.4
  • 66
    • 77958180000 scopus 로고    scopus 로고
    • Central role of fatty liver in the pathogenesis of insulin resistance in obese adolescents
    • D'Adamo, E., et al. Central role of fatty liver in the pathogenesis of insulin resistance in obese adolescents. Diabetes Care 33, 1817-1822 (2010).
    • (2010) Diabetes Care , vol.33 , pp. 1817-1822
    • D'Adamo, E.1
  • 67
    • 84899974579 scopus 로고    scopus 로고
    • Relationships of body composition and liver fat content with insulin resistance in obesity-matched adolescents and adults
    • Linder, K., et al. Relationships of body composition and liver fat content with insulin resistance in obesity-matched adolescents and adults. Obesity (Silver Spring) 22, 1325-1331 (2014).
    • (2014) Obesity (Silver Spring) , vol.22 , pp. 1325-1331
    • Linder, K.1
  • 68
    • 34547514221 scopus 로고    scopus 로고
    • Relationship between hepatic/visceral fat and hepatic insulin resistance in nondiabetic and type 2 diabetic subjects
    • Gastaldelli, A., et al. Relationship between hepatic/visceral fat and hepatic insulin resistance in nondiabetic and type 2 diabetic subjects. Gastroenterology 133, 496-506 (2007).
    • (2007) Gastroenterology , vol.133 , pp. 496-506
    • Gastaldelli, A.1
  • 69
    • 38949192017 scopus 로고    scopus 로고
    • Increased fat accumulation in liver may link insulin resistance with subcutaneous abdominal adipocyte enlargement, visceral adiposity, and hypoadiponectinemia in obese individuals
    • Koska, J., et al. Increased fat accumulation in liver may link insulin resistance with subcutaneous abdominal adipocyte enlargement, visceral adiposity, and hypoadiponectinemia in obese individuals. Am. J. Clin. Nutr. 87, 295-302 (2008).
    • (2008) Am. J. Clin. Nutr. , vol.87 , pp. 295-302
    • Koska, J.1
  • 70
    • 49449092403 scopus 로고    scopus 로고
    • Identification and characterization of metabolically benign obesity in humans
    • Stefan, N., et al. Identification and characterization of metabolically benign obesity in humans. Arch. Intern. Med. 168, 1609-1616 (2008).
    • (2008) Arch. Intern. Med. , vol.168 , pp. 1609-1616
    • Stefan, N.1
  • 71
    • 84959114791 scopus 로고    scopus 로고
    • Hepatic fat content is a determinant of metabolic phenotypes and increased carotid intima-media thickness in obese adults
    • Zhang, H., et al. Hepatic fat content is a determinant of metabolic phenotypes and increased carotid intima-media thickness in obese adults. Sci. Rep. 6, 21894 (2016).
    • (2016) Sci. Rep. , vol.6 , pp. 21894
    • Zhang, H.1
  • 72
    • 0029073613 scopus 로고
    • Weight-reducing effects of the plasma protein encoded by the obese gene
    • Halaas, J. L., et al. Weight-reducing effects of the plasma protein encoded by the obese gene. Science 269, 543-546 (1995).
    • (1995) Science , vol.269 , pp. 543-546
    • Halaas, J.L.1
  • 73
    • 0033636780 scopus 로고    scopus 로고
    • Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice
    • Shimomura, I., et al. Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice. Mol. Cell 6, 77-86 (2000).
    • (2000) Mol. Cell , vol.6 , pp. 77-86
    • Shimomura, I.1
  • 74
    • 0030689043 scopus 로고    scopus 로고
    • Mechanisms of liver and muscle insulin resistance induced by chronic high-fat feeding
    • Oakes, N. D., Cooney, G. J., Camilleri, S., Chisholm, D. J. & Kraegen, E. W. Mechanisms of liver and muscle insulin resistance induced by chronic high-fat feeding. Diabetes 46, 1768-1774 (1997).
    • (1997) Diabetes , vol.46 , pp. 1768-1774
    • Oakes, N.D.1    Cooney, G.J.2    Camilleri, S.3    Chisholm, D.J.4    Kraegen, E.W.5
  • 75
    • 3543029821 scopus 로고    scopus 로고
    • Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease
    • Samuel, V. T., et al. Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease. J. Biol. Chem. 279, 32345-32353 (2004).
    • (2004) J. Biol. Chem. , vol.279 , pp. 32345-32353
    • Samuel, V.T.1
  • 76
    • 0026040907 scopus 로고
    • Development of muscle insulin resistance after liver insulin resistance in high-fat-fed rats
    • Kraegen, E. W., et al. Development of muscle insulin resistance after liver insulin resistance in high-fat-fed rats. Diabetes 40, 1397-1403 (1991).
    • (1991) Diabetes , vol.40 , pp. 1397-1403
    • Kraegen, E.W.1
  • 77
    • 77954274018 scopus 로고    scopus 로고
    • Early hepatic insulin resistance precedes the onset of diabetes in obese C57BLKS-db/db mice
    • Davis, R. C., et al. Early hepatic insulin resistance precedes the onset of diabetes in obese C57BLKS-db/db mice. Diabetes 59, 1616-1625 (2010).
    • (2010) Diabetes , vol.59 , pp. 1616-1625
    • Davis, R.C.1
  • 78
    • 0035912744 scopus 로고    scopus 로고
    • Tissue-specific overexpression of lipoprotein lipase causes tissue-specific insulin resistance
    • Kim, J. K., et al. Tissue-specific overexpression of lipoprotein lipase causes tissue-specific insulin resistance. Proc. Natl Acad. Sci. USA 98, 7522-7527 (2001).
    • (2001) Proc. Natl Acad. Sci. USA , vol.98 , pp. 7522-7527
    • Kim, J.K.1
  • 79
    • 33645820583 scopus 로고    scopus 로고
    • Liver-directed overexpression of mitochondrial glycerol-3-phosphate acyltransferase results in hepatic steatosis, increased triacylglycerol secretion and reduced fatty acid oxidation
    • Linden, D., et al. Liver-directed overexpression of mitochondrial glycerol-3-phosphate acyltransferase results in hepatic steatosis, increased triacylglycerol secretion and reduced fatty acid oxidation. FASEB J. 20, 434-443 (2006).
    • (2006) FASEB J. , vol.20 , pp. 434-443
    • Linden, D.1
  • 80
    • 27244440736 scopus 로고    scopus 로고
    • Prevention of hepatic steatosis and hepatic insulin resistance in mitochondrial acyl-CoA:glycerol-sn-3-phosphate acyltransferase 1 knockout mice
    • Neschen, S., et al. Prevention of hepatic steatosis and hepatic insulin resistance in mitochondrial acyl-CoA:glycerol-sn-3-phosphate acyltransferase 1 knockout mice. Cell Metab. 2, 55-65 (2005).
    • (2005) Cell Metab. , vol.2 , pp. 55-65
    • Neschen, S.1
  • 81
    • 2342509057 scopus 로고    scopus 로고
    • Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistance
    • An, J., et al. Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistance. Nat. Med. 10, 268-274 (2004).
    • (2004) Nat. Med. , vol.10 , pp. 268-274
    • An, J.1
  • 82
    • 79953787445 scopus 로고    scopus 로고
    • Adipose triacylglycerol lipase is a major regulator of hepatic lipid metabolism but not insulin sensitivity in mice
    • Turpin, S. M., et al. Adipose triacylglycerol lipase is a major regulator of hepatic lipid metabolism but not insulin sensitivity in mice. Diabetologia 54, 146-156 (2011).
    • (2011) Diabetologia , vol.54 , pp. 146-156
    • Turpin, S.M.1
  • 83
    • 33644654777 scopus 로고    scopus 로고
    • Reversal of diet-induced hepatic steatosis and hepatic insulin resistance by antisense oligonucleotide inhibitors of acetyl-CoA carboxylases 1 and 2
    • Savage, D. B., et al. Reversal of diet-induced hepatic steatosis and hepatic insulin resistance by antisense oligonucleotide inhibitors of acetyl-CoA carboxylases 1 and 2. J. Clin. Invest. 116, 817-824 (2006).
    • (2006) J. Clin. Invest. , vol.116 , pp. 817-824
    • Savage, D.B.1
  • 84
    • 34547946930 scopus 로고    scopus 로고
    • Suppression of diacylglycerol acyltransferase-2 (DGAT2), but not DGAT1, with antisense oligonucleotides reverses diet-induced hepatic steatosis and insulin resistance
    • Choi, C. S., et al. Suppression of diacylglycerol acyltransferase-2 (DGAT2), but not DGAT1, with antisense oligonucleotides reverses diet-induced hepatic steatosis and insulin resistance. J. Biol. Chem. 282, 22678-22688 (2007).
    • (2007) J. Biol. Chem. , vol.282 , pp. 22678-22688
    • Choi, C.S.1
  • 85
    • 34347235098 scopus 로고    scopus 로고
    • Dissociation of hepatic steatosis and insulin resistance in mice overexpressing DGAT in the liver
    • Monetti, M., et al. Dissociation of hepatic steatosis and insulin resistance in mice overexpressing DGAT in the liver. Cell Metab. 6, 69-78 (2007).
    • (2007) Cell Metab. , vol.6 , pp. 69-78
    • Monetti, M.1
  • 86
    • 79959550724 scopus 로고    scopus 로고
    • Deficiency of liver adipose triglyceride lipase in mice causes progressive hepatic steatosis
    • Wu, J. W., et al. Deficiency of liver adipose triglyceride lipase in mice causes progressive hepatic steatosis. Hepatology 54, 122-132 (2011).
    • (2011) Hepatology , vol.54 , pp. 122-132
    • Wu, J.W.1
  • 87
    • 77954575279 scopus 로고    scopus 로고
    • Impaired de novo choline synthesis explains why phosphatidylethanolamine N-methyltransferase-deficient mice are protected from diet-induced obesity
    • Jacobs, R. L., et al. Impaired de novo choline synthesis explains why phosphatidylethanolamine N-methyltransferase-deficient mice are protected from diet-induced obesity. J. Biol. Chem. 285, 22403-22413 (2010).
    • (2010) J. Biol. Chem. , vol.285 , pp. 22403-22413
    • Jacobs, R.L.1
  • 88
    • 84871655682 scopus 로고    scopus 로고
    • Dissociating fatty liver and diabetes
    • Sun, Z. & Lazar, M. A. Dissociating fatty liver and diabetes. Trends Endocrinol. Metab. 24, 4-12 (2013).
    • (2013) Trends Endocrinol. Metab. , vol.24 , pp. 4-12
    • Sun, Z.1    Lazar, M.A.2
  • 89
    • 66349088529 scopus 로고    scopus 로고
    • Hepatic triacylglycerol accumulation and insulin resistance
    • Nagle, C. A., Klett, E. L. & Coleman, R. A. Hepatic triacylglycerol accumulation and insulin resistance. J. Lipid Res. 50 (Suppl.), S74-S79 (2009).
    • (2009) J. Lipid Res. , vol.50 , pp. S74-S79
    • Nagle, C.A.1    Klett, E.L.2    Coleman, R.A.3
  • 90
    • 0036312905 scopus 로고    scopus 로고
    • Fat accumulation in the liver is associated with defects in insulin suppression of glucose production and serum free fatty acids independent of obesity in normal men
    • Seppala-Lindroos, A., et al. Fat accumulation in the liver is associated with defects in insulin suppression of glucose production and serum free fatty acids independent of obesity in normal men. J. Clin. Endocrinol. Metab. 87, 3023-3028 (2002).
    • (2002) J. Clin. Endocrinol. Metab. , vol.87 , pp. 3023-3028
    • Seppala-Lindroos, A.1
  • 91
    • 33845490856 scopus 로고    scopus 로고
    • Review: The role of insulin resistance in nonalcoholic fatty liver disease
    • Utzschneider, K. M. & Kahn, S. E. Review: The role of insulin resistance in nonalcoholic fatty liver disease. J. Clin. Endocrinol. Metab. 91, 4753-4761 (2006).
    • (2006) J. Clin. Endocrinol. Metab. , vol.91 , pp. 4753-4761
    • Utzschneider, K.M.1    Kahn, S.E.2
  • 92
    • 84901944641 scopus 로고    scopus 로고
    • The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes
    • Perry, R. J., Samuel, V. T., Petersen, K. F. & Shulman, G. I. The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes. Nature 510, 84-91 (2014).
    • (2014) Nature , vol.510 , pp. 84-91
    • Perry, R.J.1    Samuel, V.T.2    Petersen, K.F.3    Shulman, G.I.4
  • 93
    • 36349024819 scopus 로고    scopus 로고
    • A lipidomic analysis of nonalcoholic fatty liver disease
    • Puri, P., et al. A lipidomic analysis of nonalcoholic fatty liver disease. Hepatology 46, 1081-1090 (2007).
    • (2007) Hepatology , vol.46 , pp. 1081-1090
    • Puri, P.1
  • 94
    • 80053627289 scopus 로고    scopus 로고
    • Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease
    • Kumashiro, N., et al. Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease. Proc. Natl Acad. Sci. USA 108, 16381-16385 (2011).
    • (2011) Proc. Natl Acad. Sci. USA , vol.108 , pp. 16381-16385
    • Kumashiro, N.1
  • 95
    • 84861647226 scopus 로고    scopus 로고
    • Intrahepatic diacylglycerol content is associated with hepatic insulin resistance in obese subjects
    • e2
    • Magkos, F., et al. Intrahepatic diacylglycerol content is associated with hepatic insulin resistance in obese subjects. Gastroenterology 142, 1444-1446.e2 (2012).
    • (2012) Gastroenterology , vol.142 , pp. 1444-1446
    • Magkos, F.1
  • 96
    • 84942103324 scopus 로고    scopus 로고
    • Ceramides-lipotoxic inducers of metabolic disorders
    • Chaurasia, B. & Summers, S. A. Ceramides-lipotoxic inducers of metabolic disorders. Trends Endocrinol. Metab. 26, 538-550 (2015).
    • (2015) Trends Endocrinol. Metab. , vol.26 , pp. 538-550
    • Chaurasia, B.1    Summers, S.A.2
  • 97
    • 84949627236 scopus 로고    scopus 로고
    • Regulation of metabolism by the innate immune system
    • Lackey, D. E. & Olefsky, J. M. Regulation of metabolism by the innate immune system. Nat. Rev. Endocrinol. 12, 15-28 (2016).
    • (2016) Nat. Rev. Endocrinol. , vol.12 , pp. 15-28
    • Lackey, D.E.1    Olefsky, J.M.2
  • 98
    • 5644231992 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes
    • Ozcan, U., et al. Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science 306, 457-461 (2004).
    • (2004) Science , vol.306 , pp. 457-461
    • Ozcan, U.1
  • 99
    • 33748069813 scopus 로고    scopus 로고
    • Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes
    • Ozcan, U., et al. Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes. Science 313, 1137-1140 (2006).
    • (2006) Science , vol.313 , pp. 1137-1140
    • Ozcan, U.1
  • 100
    • 84855305763 scopus 로고    scopus 로고
    • Alcohol disrupts endoplasmic reticulum function and protein secretion in hepatocytes
    • Howarth, D. L., et al. Alcohol disrupts endoplasmic reticulum function and protein secretion in hepatocytes. Alcohol Clin. Exp. Res. 36, 14-23 (2012).
    • (2012) Alcohol Clin. Exp. Res. , vol.36 , pp. 14-23
    • Howarth, D.L.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.