-
1
-
-
0037177592
-
Unraveling the causes of diabetes
-
Marx J: Unraveling the causes of diabetes. Science 2002, 296:686-689
-
(2002)
Science
, vol.296
, pp. 686-689
-
-
Marx, J.1
-
2
-
-
0031786344
-
Diabetes in America: Epidemiology and scope of the problem
-
Harris MI: Diabetes in America: epidemiology and scope of the problem. Diabetes Care 1998, 21(Suppl 3):C11-C14
-
(1998)
Diabetes Care
, vol.21
, Issue.SUPPL. 3
-
-
Harris, M.I.1
-
3
-
-
0035048313
-
Using beta-cell growth factors to enhance human pancreatic Islet transplantation
-
Garcia-Ocana A, Vasavada RC, Takane KK, Cebrian A, Lopez-Talavera JC, Stewart AF: Using beta-cell growth factors to enhance human pancreatic Islet transplantation. J Clin Endocrinol Metab 2001, 86:984-988
-
(2001)
J Clin Endocrinol Metab
, vol.86
, pp. 984-988
-
-
Garcia-Ocana, A.1
Vasavada, R.C.2
Takane, K.K.3
Cebrian, A.4
Lopez-Talavera, J.C.5
Stewart, A.F.6
-
4
-
-
0038711652
-
Hepatocyte growth factor preserves beta cell mass and mitigates hyperglycemia in streptozotocin-induced diabetic mice
-
Dai C, Li Y, Yang J, Liu Y: Hepatocyte growth factor preserves beta cell mass and mitigates hyperglycemia in streptozotocin-induced diabetic mice. J Biol Chem 2003, 278:27080-27087
-
(2003)
J Biol Chem
, vol.278
, pp. 27080-27087
-
-
Dai, C.1
Li, Y.2
Yang, J.3
Liu, Y.4
-
5
-
-
0037414812
-
Adenovirus-mediated hepatocyte growth factor expression in mouse islets improves pancreatic islet transplant performance and reduces beta cell death
-
Garcia-Ocana A, Takane KK, Reddy VT, Lopez-Talavera JC, Vasavada RC, Stewart AF: Adenovirus-mediated hepatocyte growth factor expression in mouse islets improves pancreatic islet transplant performance and reduces beta cell death. J Biol Chem 2003, 278:343-351
-
(2003)
J Biol Chem
, vol.278
, pp. 343-351
-
-
Garcia-Ocana, A.1
Takane, K.K.2
Reddy, V.T.3
Lopez-Talavera, J.C.4
Vasavada, R.C.5
Stewart, A.F.6
-
7
-
-
2942635909
-
Hepatocyte growth factor in kidney fibrosis: Therapeutic potential and mechanisms of action
-
Liu Y: Hepatocyte growth factor in kidney fibrosis: therapeutic potential and mechanisms of action. Am J Physiol 2004, 287:F7-F16
-
(2004)
Am J Physiol
, vol.287
-
-
Liu, Y.1
-
8
-
-
0025805633
-
Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product
-
Bottaro DP, Rubin JS, Faletto DL, Chan AM, Kmiecik TE, Vande Woude GF, Aaronson SA: Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product. Science 1991, 251:802-804
-
(1991)
Science
, vol.251
, pp. 802-804
-
-
Bottaro, D.P.1
Rubin, J.S.2
Faletto, D.L.3
Chan, A.M.4
Kmiecik, T.E.5
Vande Woude, G.F.6
Aaronson, S.A.7
-
9
-
-
0025734655
-
Hepatocyte growth factor (HGF) stimulates the tyrosine kinase activity of the receptor encoded by the proto-oncogene c-MET
-
Naldini L, Vigna E, Narsimhan RP, Gaudino G, Zarnegar R, Michalopoulos GK, Comoglio PM: Hepatocyte growth factor (HGF) stimulates the tyrosine kinase activity of the receptor encoded by the proto-oncogene c-MET. Oncogene 1991, 6:501-504
-
(1991)
Oncogene
, vol.6
, pp. 501-504
-
-
Naldini, L.1
Vigna, E.2
Narsimhan, R.P.3
Gaudino, G.4
Zarnegar, R.5
Michalopoulos, G.K.6
Comoglio, P.M.7
-
10
-
-
0028284507
-
Hepatocyte growth factor/scatter factor has insulinotropic activity in human fetal pancreatic cells
-
Otonkoski T, Beattie GM, Rubin JS, Lopez AD, Baird A, Hayek A: Hepatocyte growth factor/scatter factor has insulinotropic activity in human fetal pancreatic cells. Diabetes 1994, 43:947-953
-
(1994)
Diabetes
, vol.43
, pp. 947-953
-
-
Otonkoski, T.1
Beattie, G.M.2
Rubin, J.S.3
Lopez, A.D.4
Baird, A.5
Hayek, A.6
-
11
-
-
0030015057
-
A role for hepatocyte growth factor/scatter factor in fetal mesenchyme-induced pancreatic beta-cell growth
-
Otonkoski T, Cirulli V, Beattie M, Mally MI, Soto G, Rubin JS, Hayek A: A role for hepatocyte growth factor/scatter factor in fetal mesenchyme-induced pancreatic beta-cell growth. Endocrinology 1996, 137:3131-3139
-
(1996)
Endocrinology
, vol.137
, pp. 3131-3139
-
-
Otonkoski, T.1
Cirulli, V.2
Beattie, M.3
Mally, M.I.4
Soto, G.5
Rubin, J.S.6
Hayek, A.7
-
12
-
-
0034719348
-
Hepatocyte growth factor is essential for amelioration of hyperglycemia in streptozotocin-induced diabetic mice receiving a marginal mass of intrahepatic islet grafts
-
Nakano M, Yasunami Y, Maki T, Kodama S, Ikehara Y, Nakamura T, Tanaka M, Ikeda S: Hepatocyte growth factor is essential for amelioration of hyperglycemia in streptozotocin-induced diabetic mice receiving a marginal mass of intrahepatic islet grafts. Transplantation 2000, 69:214-221
-
(2000)
Transplantation
, vol.69
, pp. 214-221
-
-
Nakano, M.1
Yasunami, Y.2
Maki, T.3
Kodama, S.4
Ikehara, Y.5
Nakamura, T.6
Tanaka, M.7
Ikeda, S.8
-
13
-
-
0035650568
-
Transgenic overexpression of hepatocyte growth factor in the beta-cell markedly improves islet function and islet transplant outcomes in mice
-
Garcia-Ocana A, Vasavada RC, Cebrian A, Reddy V, Takane KK, Lopez-Talavera JC, Stewart AF: Transgenic overexpression of hepatocyte growth factor in the beta-cell markedly improves islet function and islet transplant outcomes in mice. Diabetes 2001, 50:2752-2762
-
(2001)
Diabetes
, vol.50
, pp. 2752-2762
-
-
Garcia-Ocana, A.1
Vasavada, R.C.2
Cebrian, A.3
Reddy, V.4
Takane, K.K.5
Lopez-Talavera, J.C.6
Stewart, A.F.7
-
14
-
-
0033954474
-
Hepatocyte growth factor overexpression in the islet of transgenic mice increases beta cell proliferation, enhances islet mass, and induces mild hypoglycemia
-
Garcia-Ocana A, Takane KK, Syed MA, Philbrick WM, Vasavada RC, Stewart AF: Hepatocyte growth factor overexpression in the islet of transgenic mice increases beta cell proliferation, enhances islet mass, and induces mild hypoglycemia. J Biol Chem 2000, 275:1226-1232
-
(2000)
J Biol Chem
, vol.275
, pp. 1226-1232
-
-
Garcia-Ocana, A.1
Takane, K.K.2
Syed, M.A.3
Philbrick, W.M.4
Vasavada, R.C.5
Stewart, A.F.6
-
15
-
-
0028899952
-
Scatter factor/hepatocyte growth factor is essential for liver development
-
Schmidt C, Bladt F, Goedecke S, Brinkmann V, Zschiesche W, Sharpe M, Gherardi E, Birchmeier C: Scatter factor/hepatocyte growth factor is essential for liver development. Nature 1995, 373:699-702
-
(1995)
Nature
, vol.373
, pp. 699-702
-
-
Schmidt, C.1
Bladt, F.2
Goedecke, S.3
Brinkmann, V.4
Zschiesche, W.5
Sharpe, M.6
Gherardi, E.7
Birchmeier, C.8
-
16
-
-
0029134104
-
Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud
-
Bladt F, Riethmacher D, Isenmann S, Aguzzi A, Birchmeier C: Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud. Nature 1995, 376:768-771
-
(1995)
Nature
, vol.376
, pp. 768-771
-
-
Bladt, F.1
Riethmacher, D.2
Isenmann, S.3
Aguzzi, A.4
Birchmeier, C.5
-
17
-
-
0028911690
-
Placental defect and embryonic lethality in mice lacking hepatocyte growth factor/scatter factor
-
Uehara Y, Minowa O, Mori C, Shiota K, Kuno J, Noda T, Kitamura N: Placental defect and embryonic lethality in mice lacking hepatocyte growth factor/scatter factor. Nature 1995, 373:702-705
-
(1995)
Nature
, vol.373
, pp. 702-705
-
-
Uehara, Y.1
Minowa, O.2
Mori, C.3
Shiota, K.4
Kuno, J.5
Noda, T.6
Kitamura, N.7
-
18
-
-
1842428601
-
Hepatocyte growth factor/c-met signaling pathway is required for efficient liver regeneration and repair
-
Huh CG, Factor VM, Sanchez A, Uchida K, Conner EA, Thorgeirsson SS: Hepatocyte growth factor/c-met signaling pathway is required for efficient liver regeneration and repair. Proc Natl Acad Sci USA 2004, 101:4477-4482
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 4477-4482
-
-
Huh, C.G.1
Factor, V.M.2
Sanchez, A.3
Uchida, K.4
Conner, E.A.5
Thorgeirsson, S.S.6
-
19
-
-
0033524937
-
Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes
-
Kulkarni RN, Bruning JC, Winnay JN, Postic C, Magnuson MA, Kahn CR: Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes. Cell 1999, 96:329-339
-
(1999)
Cell
, vol.96
, pp. 329-339
-
-
Kulkarni, R.N.1
Bruning, J.C.2
Winnay, J.N.3
Postic, C.4
Magnuson, M.A.5
Kahn, C.R.6
-
20
-
-
0032898369
-
Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase
-
Postic C, Shiota M, Niswender KD, Jetton TL, Chen Y, Moates JM, Shelton KD, Lindner J, Cherrington AD, Magnuson MA: Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase. J Biol Chem 1999, 274:305-315
-
(1999)
J Biol Chem
, vol.274
, pp. 305-315
-
-
Postic, C.1
Shiota, M.2
Niswender, K.D.3
Jetton, T.L.4
Chen, Y.5
Moates, J.M.6
Shelton, K.D.7
Lindner, J.8
Cherrington, A.D.9
Magnuson, M.A.10
-
21
-
-
0036138824
-
Blockage of tubular epithelial to myofibroblast transition by hepatocyte growth factor prevents renal interstitial fibrosis
-
Yang J, Liu Y: Blockage of tubular epithelial to myofibroblast transition by hepatocyte growth factor prevents renal interstitial fibrosis. J Am Soc Nephrol 2002, 13:96-107
-
(2002)
J Am Soc Nephrol
, vol.13
, pp. 96-107
-
-
Yang, J.1
Liu, Y.2
-
22
-
-
0036854980
-
Disruption of tissue-type plasminogen activator gene in mice reduces renal interstitial fibrosis in obstructive nephropathy
-
Yang J, Shultz RW, Mars WM, Wegner RE, Li Y, Dai C, Nejak K, Liu Y: Disruption of tissue-type plasminogen activator gene in mice reduces renal interstitial fibrosis in obstructive nephropathy. J Clin Invest 2002, 110:1525-1538
-
(2002)
J Clin Invest
, vol.110
, pp. 1525-1538
-
-
Yang, J.1
Shultz, R.W.2
Mars, W.M.3
Wegner, R.E.4
Li, Y.5
Dai, C.6
Nejak, K.7
Liu, Y.8
-
23
-
-
0036066970
-
Knockout models are useful tools to dissect the pathophysiology and genetics of insulin resistance
-
Mauvais-Jarvis F, Kulkarni RN, Kahn CR: Knockout models are useful tools to dissect the pathophysiology and genetics of insulin resistance. Clin Endocrinol (Oxf) 2002, 57:1-9
-
(2002)
Clin Endocrinol (Oxf)
, vol.57
, pp. 1-9
-
-
Mauvais-Jarvis, F.1
Kulkarni, R.N.2
Kahn, C.R.3
-
24
-
-
0041306886
-
The Gordon Wilson Lecture. Lessons about the control of glucose homeostasis and the pathogenesis of diabetes from knockout mice
-
Kahn CR: The Gordon Wilson Lecture. Lessons about the control of glucose homeostasis and the pathogenesis of diabetes from knockout mice. Trans Am Clin Climatol Assoc 2003, 114:125-148
-
(2003)
Trans Am Clin Climatol Assoc
, vol.114
, pp. 125-148
-
-
Kahn, C.R.1
-
26
-
-
0030934003
-
Mechanisms of arginine-induced increase in cytosolic calcium concentration in the beta-cell line NIT-1
-
Weinhaus AJ, Poronnik P, Tuch BE, Cook DI: Mechanisms of arginine-induced increase in cytosolic calcium concentration in the beta-cell line NIT-1. Diabetologia 1997, 40:374-382
-
(1997)
Diabetologia
, vol.40
, pp. 374-382
-
-
Weinhaus, A.J.1
Poronnik, P.2
Tuch, B.E.3
Cook, D.I.4
-
27
-
-
29744434014
-
Understanding of basic mechanisms of beta-cell function and survival: Prelude to new diabetes therapies
-
Newgard CB, Hohmeier HE, Lu D, Jensen MV, Tran W, Chen G, Burgess S, Sherry AD: Understanding of basic mechanisms of beta-cell function and survival: prelude to new diabetes therapies. Cell Biochem Biophys 2004, 40:159-168
-
(2004)
Cell Biochem Biophys
, vol.40
, pp. 159-168
-
-
Newgard, C.B.1
Hohmeier, H.E.2
Lu, D.3
Jensen, M.V.4
Tran, W.5
Chen, G.6
Burgess, S.7
Sherry, A.D.8
-
28
-
-
4043096481
-
Unlocking the secrets of the pancreatic beta cell: Man and mouse provide the key
-
Hattersley AT: Unlocking the secrets of the pancreatic beta cell: man and mouse provide the key. J Clin Invest 2004, 114:314-316
-
(2004)
J Clin Invest
, vol.114
, pp. 314-316
-
-
Hattersley, A.T.1
-
29
-
-
3242656480
-
Pancreatic beta-cell growth and survival in the onset of type 2 diabetes: A role for protein kinase B in the Akt?
-
Dickson LM, Rhodes CJ: Pancreatic beta-cell growth and survival in the onset of type 2 diabetes: a role for protein kinase B in the Akt? Am J Physiol 2004, 287:E192-E198
-
(2004)
Am J Physiol
, vol.287
-
-
Dickson, L.M.1
Rhodes, C.J.2
-
30
-
-
0348048485
-
Reduced beta-cell mass and altered glucose sensing impair insulin-secretory function in betaIRKO mice
-
Otani K, Kulkarni RN, Baldwin AC, Krutzfeldt J, Ueki K, Stoffel M, Kahn CR, Polonsky KS: Reduced beta-cell mass and altered glucose sensing impair insulin-secretory function in betaIRKO mice. Am J Physiol 2004, 286:E41-E49
-
(2004)
Am J Physiol
, vol.286
-
-
Otani, K.1
Kulkarni, R.N.2
Baldwin, A.C.3
Krutzfeldt, J.4
Ueki, K.5
Stoffel, M.6
Kahn, C.R.7
Polonsky, K.S.8
-
31
-
-
0033379267
-
Altered function of insulin receptor substrate-1-deficient mouse islets and cultured beta-cell lines
-
Kulkarni RN, Winnay JN, Daniels M, Bruning JC, Flier SN, Hanahan D, Kahn CR: Altered function of insulin receptor substrate-1-deficient mouse islets and cultured beta-cell lines. J Clin Invest 1999, 104:R69-R75
-
(1999)
J Clin Invest
, vol.104
-
-
Kulkarni, R.N.1
Winnay, J.N.2
Daniels, M.3
Bruning, J.C.4
Flier, S.N.5
Hanahan, D.6
Kahn, C.R.7
-
32
-
-
0036578921
-
Beta-cell-specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter beta-cell mass
-
Kulkarni RN, Holzenberger M, Shih DQ, Ozean U, Stoffel M, Magnuson MA, Kahn CR: Beta-cell-specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter beta-cell mass. Nat Genet 2002, 31:111-115
-
(2002)
Nat Genet
, vol.31
, pp. 111-115
-
-
Kulkarni, R.N.1
Holzenberger, M.2
Shih, D.Q.3
Ozean, U.4
Stoffel, M.5
Magnuson, M.A.6
Kahn, C.R.7
-
33
-
-
0034101423
-
Analysis of the Cre-mediated recombination driven by rat insulin promoter in embryonic and adult mouse pancreas
-
Gannon M, Shiota C, Postic C, Wright CV, Magnuson M: Analysis of the Cre-mediated recombination driven by rat insulin promoter in embryonic and adult mouse pancreas. Genesis 2000, 26:139-142
-
(2000)
Genesis
, vol.26
, pp. 139-142
-
-
Gannon, M.1
Shiota, C.2
Postic, C.3
Wright, C.V.4
Magnuson, M.5
-
34
-
-
0020063236
-
Insulin responses to nonglucose stimuli in non-insulin-dependent diabetes mellitus during a tolbutamide infusion
-
Pfeifer MA, Halter JB, Beard JC, Judzewitsch R, Porte Jr D: Insulin responses to nonglucose stimuli in non-insulin-dependent diabetes mellitus during a tolbutamide infusion. Diabetes 1982, 31:154-159
-
(1982)
Diabetes
, vol.31
, pp. 154-159
-
-
Ma, P.1
Halter, J.B.2
Beard, J.C.3
Judzewitsch, R.4
Porte Jr., D.5
-
35
-
-
0029815929
-
Formation of insulin-producing cells from pancreatic acinar AR42J cells by hepatocyte growth factor
-
Mashima H, Shibata H, Mine T, Kojima I: Formation of insulin-producing cells from pancreatic acinar AR42J cells by hepatocyte growth factor. Endocrinology 1996, 137:3969-3976
-
(1996)
Endocrinology
, vol.137
, pp. 3969-3976
-
-
Mashima, H.1
Shibata, H.2
Mine, T.3
Kojima, I.4
-
36
-
-
0025736821
-
Diabetic hyperglycemic: Link to impaired glucose transport in pancreatic beta cells
-
Unger RH: Diabetic hyperglycemic: link to impaired glucose transport in pancreatic beta cells. Science 1991, 251:1200-1205
-
(1991)
Science
, vol.251
, pp. 1200-1205
-
-
Unger, R.H.1
|