C-Met is a marker of pancreatic cancer stem cells and therapeutic target

Gastroenterology

Volumn 141, Issue 6, 2011, Pages

  Li, Chenwei ^a   Wu, Jingjiang ^a   Hynes, Mark ^a   Dosch, Joseph ^a   Sarkar, Bedabrata ^a   Welling, Theodore H ^a   Pasca Di Magliano, Marina ^a,b   Simeone, Diane M ^a,c  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

^c UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

Author keywords

Mouse Model; Oncogene; shRNA; Tumorigenesis

Indexed keywords

GEMCITABINE; HERMES ANTIGEN; SCATTER FACTOR RECEPTOR; SHORT HAIRPIN RNA; XL 184;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER COMBINATION CHEMOTHERAPY; CANCER STEM CELL; CARCINOGENESIS; CARCINOGENICITY; CONTROLLED STUDY; DRUG TARGETING; HUMAN; HUMAN CELL; MONOTHERAPY; MOUSE; NONHUMAN; PANCREAS CANCER; PRIORITY JOURNAL; TUMOR GROWTH; TUMOR XENOGRAFT;

EID: 81855194258     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2011.08.009     Document Type: Article

References (35)

1. H.C. Kung, D.L. Hoyert, and J. Xu Deaths: final data for 2005 Natl Vital Stat Rep 56 2008 1 120
2. D. Bonnet, and J.E. Dick Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell Nat Med 3 1997 730 737 (Pubitemid 27298715)
3. M. Al-Hajj, M.S. Wicha, and A. Benito-Hernandez Prospective identification of tumorigenic breast cancer cells Proc Natl Acad Sci U S A 100 2003 3983 3988 (Pubitemid 36418143)
4. C. Li, D.G. Heidt, and P. Dalerba Identification of pancreatic cancer stem cells Cancer Res 67 2007 1030 1037
5. C.S. Cooper, M. Park, and D.G. Blair Molecular cloning of a new transforming gene from a chemically transformed human cell line Nature 311 1984 29 33 (Pubitemid 14065275)
6. M.F. Di Renzo, R.P. Narsimhan, and M. Olivero Expression of the Met/HGF receptor in normal and neoplastic human tissues Oncogene 6 1991 1997 2003 (Pubitemid 21924039)
7. P.M. Comoglio Structure, biosynthesis and biochemical properties of the HGF receptor in normal and malignant cells EXS 65 1993 131 165
8. S. Corso, P.M. Comoglio, and S. Giordano Cancer therapy: can the challenge be MET? Trends Mol Med 6 2005 284 292 (Pubitemid 40804792)
9. M. Ebert, M. Yokoyama, and H. Friess Coexpression of the c-met proto-oncogene and hepatocyte growth factor in human pancreatic cancer Cancer Res 54 1994 5775 5778 (Pubitemid 24375202)
10. M.F. Di Renzo, R. Poulsom, and M. Olivero Expression of the Met/hepatocyte growth factor receptor in human pancreatic cancer Cancer Res 55 1995 1129 1138
11. T. Furukawa, W.P. Duguid, and M. Kobari Hepatocyte growth factor and Met receptor expression in human pancreatic carcinogenesis Am J Pathol 147 1995 889 895
12. A. Suzuki, H. Nakauchi, and H. Taniguchi Prospective isolation of multipotent pancreatic progenitors using flow-cytometric cell sorting Diabetes 53 2004 2143 2152 (Pubitemid 38970768)
13. Y. Oshima, A. Suzuki, and K. Kawashimo Isolation of mouse pancreatic ductal progenitor cells expressing CD133 and c-Met by flow cytometric cell sorting Gastroenterology 132 2007 720 732 (Pubitemid 46274661)
14. F. Bladt, S. D. Riethmacher, and A. Isenmann Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud Nature 376 1995 768 771
15. C. Nicoleau, O. Benzakour, and F. Agasse Endogenous hepatocyte growth factor is a niche signal for subventricular zone neural stem cell amplification and self-renewal Stem Cells 27 2009 408 419
16. E. Charafe-Jauffret, C. Ginestier, and F. Iovino Breast cancer cell lines contain functional cancer stem cells with metastatic capacity and a distinct molecular signature Cancer Res 69 2009 1302 1313
17. L. Zhang, C.J. Duan, and C. Binkley A transforming growth factor beta-induced Smad3/Smad4 complex directly activates protein kinase A Mol Cell Biol 5 2004 2169 2180 (Pubitemid 38248954)
18. P.C. Hermann, S.L. Huber, and T. Herrler Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer Cell Stem Cell 1 2007 313 323 (Pubitemid 47355323)
19. L. Li, and W.B. Neaves Normal stem cells and cancer stem cells: the niche matters Cancer Res 66 2006 4553 4557
20. S.K. Singh, C. Hawkins, and I.D. Clarke Identification of human brain tumour initiating cells Nature 432 2004 396 401 (Pubitemid 39551674)
21. C. Ginestier, M.H. Hur, and E. Charafe-Jauffret ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome Cell Stem Cell 5 2007 555 567 (Pubitemid 350056407)
22. C.J. Lee, C. Li, and D.M. Simeone Human pancreatic cancer stem cells: implications for how we treat pancreatic cancer Transl Oncol 1 2008 14 18
23. Y. Zhang, F. Guessous, and A. Kofman XL-184, a MET, VEGFR-2 and RET kinase inhibitor for the treatment of thyroid cancer, glioblastoma multiforme and NSCLC IDrugs 13 2010 112 121
24. R. Salgia, D.S. Hong, and L.H. Camacho A phase I dose-escalation study of the safety and pharmacokinetics (PK) of XL184 a VEGFR and MET kinase inhibitor administered orally to patients with advanced malignancies J Clin Oncol 25 2007 14031
25. J.M. Rosen, and C.T. Jordan The increasing complexity of the cancer stem cell paradigm Science 324 2009 1670 1673
26. A.N. Shah, J.M. Summy, and J. Zhang Development and characterization of gemcitabine-resistant pancreatic tumor cells Ann Surg Oncol 14 2007 3629 3637 (Pubitemid 350160137)
27. C. Birchmeier, W. Birchmeier, and E. Gherardi Met, metastasis, motility and more Nat Rev Mol Cell Biol 4 2003 915 925 (Pubitemid 37493640)
28. E. Sonnenberg, D. Meyer, and K.M. Weidner Scatter factor/hepatocyte growth factor and its receptor, the c-met tyrosine kinase, can mediate a signal exchange between mesenchyme and epithelia during mouse development J Cell Biol 123 1993 223 235 (Pubitemid 23284877)
29. J.M. Otte, K. Kiehne, and F. Schmitz C-met protooncogene expression and its regulation by cytokines in the regenerating pancreas and in pancreatic cancer cells Scand J Gastroenterol 35 2000 90 95 (Pubitemid 30066778)
30. K. Kiehne, K.H. Herzig, and U.R. Fölsch c-Met expression in pancreatic cancer and effects of hepatocyte growth factor on pancreatic cancer cell growth Pancreas 15 1997 35 40 (Pubitemid 27527357)
31. L.W. Qian, K. Mizumoto, and N. Maehara Co-cultivation of pancreatic cancer cells with orthotopic tumor-derived fibroblasts: fibroblasts stimulate tumor cell invasion via HGF secretion whereas cancer cells exert a minor regulative effect on fibroblasts HGF production Cancer Lett 190 2003 105 112 (Pubitemid 36106561)
32. V. Orian-Rousseau, L. Chen, and J.P. Sleeman CD44 is required for two consecutive steps in HGF/c-Met signaling Genes Dev 16 2002 3074 3086 (Pubitemid 35424194)
33. E.R. Camp, A. Yang, and M.J. Gray Tyrosine kinase receptor RON in human pancreatic cancer: expression, function, and validation as a target Cancer 109 2007 1030 1039 (Pubitemid 46435380)
34. R. Abounader, B. Lal, and C. Luddy In vivo targeting of SF/HGF and c-met expression via U1snRNA/ribozymes inhibits glioma growth and angiogenesis and promotes apoptosis FASEB J 16 2002 108 110
35. J.G. Christensen, R. Schreck, and J. Burrows A selective small molecule inhibitor of c-Met kinase inhibits c-Met-dependent phenotypes in vitro and exhibits cytoreductive antitumor activity in vivo Cancer Res 63 2003 7345 7355 (Pubitemid 37413476)