메뉴 건너뛰기




Volumn 53, Issue 2, 2009, Pages 213-226

Epidemiological and molecular mechanisms aspects linking obesity and cancer;Mecanismos epidemiológicos e moleculares que associam obesidade e câncer

Author keywords

Insulin resistance; Neoplasms; Obesity; Overweight

Indexed keywords


EID: 67649413362     PISSN: 00042730     EISSN: 16779487     Source Type: Journal    
DOI: 10.1590/S0004-27302009000200013     Document Type: Review
Times cited : (58)

References (116)
  • 2
    • 33744482612 scopus 로고    scopus 로고
    • Insulin resistance/hyperinsulinemia associated diseases not included in the metabolic syndrome, Epub 2006 May 23, Review, Portuguese
    • Carvalheira JB, Saad MJ. [Insulin resistance/hyperinsulinemia associated diseases not included in the metabolic syndrome]. Arq Bras Endocrinol Metabol. 2006;50(2):360-7. Epub 2006 May 23. Review. Portuguese.
    • (2006) Arq Bras Endocrinol Metabol , vol.50 , Issue.2 , pp. 360-367
    • Carvalheira, J.B.1    Saad, M.J.2
  • 4
    • 0005313671 scopus 로고    scopus 로고
    • IARC - International Agency for Research on Cancer Working Group on the Evaluation of Cancer-Preventive Strategies, Lyon, France: IARC Press
    • IARC - International Agency for Research on Cancer Working Group on the Evaluation of Cancer-Preventive Strategies. Weight control and physical activity. Lyon, France: IARC Press; 2002.
    • (2002) Weight Control and Physical Activity
  • 6
    • 37049013701 scopus 로고    scopus 로고
    • Cancer incidence and mortality in relation to body mass index in the Million Women Study: Cohort study
    • Epub 2007 Nov 6
    • Reeves GK, Pirie K, Beral V, Green J, Spencer E, Bull D. Cancer incidence and mortality in relation to body mass index in the Million Women Study: cohort study. BMJ. 2007;335(7634):1134. Epub 2007 Nov 6.
    • (2007) BMJ , vol.335 , Issue.7634 , pp. 1134
    • Reeves, G.K.1    Pirie, K.2    Beral, V.3    Green, J.4    Spencer, E.5    Bull, D.6
  • 7
    • 38949108241 scopus 로고    scopus 로고
    • Body mass index and incidence of cancer: A systematic review and meta-analysis of prospective observational studies
    • Review
    • Renehan AG, Tyson M, Egger M, Heller RF, Zwahlen M. Body mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies. Lancet. 2008;371(9612):569-78. Review.
    • (2008) Lancet , vol.371 , Issue.9612 , pp. 569-578
    • Renehan, A.G.1    Tyson, M.2    Egger, M.3    Heller, R.F.4    Zwahlen, M.5
  • 8
    • 47349129465 scopus 로고    scopus 로고
    • Obesity and cancer: Pathophysiological and biological mechanisms
    • Review
    • Renehan AG, Roberts DL, Dive C. Obesity and cancer: pathophysiological and biological mechanisms. Arch Physiol Biochem. 2008;114(1):71-83. Review.
    • (2008) Arch Physiol Biochem , vol.114 , Issue.1 , pp. 71-83
    • Renehan, A.G.1    Roberts, D.L.2    Dive, C.3
  • 9
    • 0037464510 scopus 로고    scopus 로고
    • Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults
    • Calle EE, Rodriguez C, Walker-Thurmond K, Thun MJ. Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. N Engl J Med. 2003;348(17):1625-38.
    • (2003) N Engl J Med , vol.348 , Issue.17 , pp. 1625-1638
    • Calle, E.E.1    Rodriguez, C.2    Walker-Thurmond, K.3    Thun, M.J.4
  • 10
    • 33751509395 scopus 로고    scopus 로고
    • Increased tumor growth in mice with diet-induced obesity: Impact of ovarian hormones
    • Epub 2006 Sep 7
    • Yakar S, Nunez NP, Pennisi P, Brodt P, Sun H, Fallavollita L, et al. Increased tumor growth in mice with diet-induced obesity: impact of ovarian hormones. Endocrinology. 2006;147 (12):5826-34. Epub 2006 Sep 7.
    • (2006) Endocrinology , vol.147 , Issue.12 , pp. 5826-5834
    • Yakar, S.1    Nunez, N.P.2    Pennisi, P.3    Brodt, P.4    Sun, H.5    Fallavollita, L.6
  • 12
    • 0034597647 scopus 로고    scopus 로고
    • Obesity, hypertension, and the risk of kidney cancer in men
    • Chow WH, Gridley G, Fraumeni JF Jr, Järvholm B. Obesity, hypertension, and the risk of kidney cancer in men. N Engl J Med. 2000;343(18):1305-11.
    • (2000) N Engl J Med , vol.343 , Issue.18 , pp. 1305-1311
    • Chow, W.H.1    Gridley, G.2    Fraumeni Jr., J.F.3    Järvholm, B.4
  • 13
    • 33947191596 scopus 로고    scopus 로고
    • Body mass index and pancreatic cancer risk: A meta-analysis of prospective studies
    • Larsson SC, Orsini N, Wolk A. Body mass index and pancreatic cancer risk: a meta-analysis of prospective studies. Int J Cancer. 2007;120(9):1993-8.
    • (2007) Int J Cancer , vol.120 , Issue.9 , pp. 1993-1998
    • Larsson, S.C.1    Orsini, N.2    Wolk, A.3
  • 14
    • 33745774113 scopus 로고    scopus 로고
    • Body size and risk of colon and rectal cancer in the European Prospective Investigation Into Cancer and Nutrition (EPIC)
    • Pischon T, Lahmann PH, Boeing H, Friedenreich C, Norat T, Tjønneland A, et al. Body size and risk of colon and rectal cancer in the European Prospective Investigation Into Cancer and Nutrition (EPIC). J Natl Cancer Inst. 2006;98(13):920-31.
    • (2006) J Natl Cancer Inst , vol.98 , Issue.13 , pp. 920-931
    • Pischon, T.1    Lahmann, P.H.2    Boeing, H.3    Friedenreich, C.4    Norat, T.5    Tjønneland, A.6
  • 15
    • 34250321324 scopus 로고    scopus 로고
    • Serum C-peptide, IGFBP-1 and IGFBP-2 and risk of colon and rectal cancers in the European Prospective Investigation into Cancer and Nutrition
    • Jenab M, Riboli E, Cleveland RJ, Norat T, Rinaldi S, Nieters A, et al. Serum C-peptide, IGFBP-1 and IGFBP-2 and risk of colon and rectal cancers in the European Prospective Investigation into Cancer and Nutrition. Int J Cancer. 2007;121(2):368-76.
    • (2007) Int J Cancer , vol.121 , Issue.2 , pp. 368-376
    • Jenab, M.1    Riboli, E.2    Cleveland, R.J.3    Norat, T.4    Rinaldi, S.5    Nieters, A.6
  • 16
    • 0037014743 scopus 로고    scopus 로고
    • Insulin, insulin-like growth factor-I (IGF-I), IGF binding proteins, their biologic interactions, and colorectal cancer
    • Sandhu MS, Dunger DB, Giovannucci EL. Insulin, insulin-like growth factor-I (IGF-I), IGF binding proteins, their biologic interactions, and colorectal cancer. J Natl Cancer Inst. 2002;94(136):972-80.
    • (2002) J Natl Cancer Inst , vol.94 , Issue.136 , pp. 972-980
    • Sandhu, M.S.1    Dunger, D.B.2    Giovannucci, E.L.3
  • 17
    • 1942436958 scopus 로고    scopus 로고
    • Insulin-like growth factor (IGF)-I, IGF binding protein-3, and cancer risk: Systematic review and meta-regression analysis
    • Renehan AG, Zwahlen M, Minder C, O'Dwyer ST, Shalet SM, Egger M. Insulin-like growth factor (IGF)-I, IGF binding protein-3, and cancer risk: systematic review and meta-regression analysis. Lancet. 2004;363(9418):1346-53.
    • (2004) Lancet , vol.363 , Issue.9418 , pp. 1346-1353
    • Renehan, A.G.1    Zwahlen, M.2    Minder, C.3    O'Dwyer, S.T.4    Shalet, S.M.5    Egger, M.6
  • 18
    • 0033531765 scopus 로고    scopus 로고
    • Prospective study of colorectal cancer risk in men and plasma levels of insulin-like growth factor (IGF)-I and IGF-binding protein-3
    • Ma J, Pollak MN, Giovannucci E, Chan JM, Tao Y, Hennekens CH, et al. Prospective study of colorectal cancer risk in men and plasma levels of insulin-like growth factor (IGF)-I and IGF-binding protein-3. J Natl Cancer Inst. 1999;91(7):620-5.
    • (1999) J Natl Cancer Inst , vol.91 , Issue.7 , pp. 620-625
    • Ma, J.1    Pollak, M.N.2    Giovannucci, E.3    Chan, J.M.4    Tao, Y.5    Hennekens, C.H.6
  • 19
    • 58249092146 scopus 로고    scopus 로고
    • Insulin, the insulin-like growth factor axis, and mortality in patients with nonmetastatic colorectal cancer
    • Epub 2008 Dec 8
    • Wolpin BM, Meyerhardt JA, Chan AT, Ng K, Chan JA, Wu K, et al. Insulin, the insulin-like growth factor axis, and mortality in patients with nonmetastatic colorectal cancer. J Clin Oncol. 2009;27(2):176-85. Epub 2008 Dec 8.
    • (2009) J Clin Oncol , vol.27 , Issue.2 , pp. 176-185
    • Wolpin, B.M.1    Meyerhardt, J.A.2    Chan, A.T.3    Ng, K.4    Chan, J.A.5    Wu, K.6
  • 20
    • 0026316096 scopus 로고
    • Growth factors and cancer
    • Review
    • Aaronson SA. Growth factors and cancer. Science. 1991;254(5035):1146-53. Review.
    • (1991) Science , vol.254 , Issue.5035 , pp. 1146-1153
    • Aaronson, S.A.1
  • 21
    • 0035123520 scopus 로고    scopus 로고
    • Energy balance and cancer: The role of insulin and insulin-like growth factor-I
    • Review
    • Kaaks R, Lukanova A. Energy balance and cancer: the role of insulin and insulin-like growth factor-I. Proc Nutr Soc. 2001;60(1):91-106. Review.
    • (2001) Proc Nutr Soc , vol.60 , Issue.1 , pp. 91-106
    • Kaaks, R.1    Lukanova, A.2
  • 24
    • 0039379120 scopus 로고    scopus 로고
    • Obesity
    • Björntorp P. Obesity. Lancet. 1997;350(9075):423-6.
    • (1997) Lancet , vol.350 , Issue.9075 , pp. 423-426
    • Björntorp, P.1
  • 25
    • 0029948025 scopus 로고    scopus 로고
    • Physical activity, obesity, and risk of colorectal adenoma in women (United States)
    • Giovannucci E, Colditz GA, Stampfer MJ, Willett WC. Physical activity, obesity, and risk of colorectal adenoma in women (United States). Cancer Causes Control. 1996;7(2):253-63.
    • (1996) Cancer Causes Control , vol.7 , Issue.2 , pp. 253-263
    • Giovannucci, E.1    Colditz, G.A.2    Stampfer, M.J.3    Willett, W.C.4
  • 26
    • 0742277837 scopus 로고    scopus 로고
    • Plasma leptin and colorectal cancer risk: A prospective study in Northern Sweden
    • Stattin P, Palmqvist R, Söderberg S, Biessy C, Ardnor B, Hallmans G, et al. Plasma leptin and colorectal cancer risk: a prospective study in Northern Sweden. Oncol Rep. 2003;10(6):2015-21.
    • (2003) Oncol Rep , vol.10 , Issue.6 , pp. 2015-2021
    • Stattin, P.1    Palmqvist, R.2    Söderberg, S.3    Biessy, C.4    Ardnor, B.5    Hallmans, G.6
  • 27
    • 27944506001 scopus 로고    scopus 로고
    • Low plasma adiponectin levels and risk of colorectal cancer in men: A prospective study
    • Wei EK, Giovannucci E, Fuchs CS, Willett WC, Mantzoros CS. Low plasma adiponectin levels and risk of colorectal cancer in men: a prospective study. J Natl Cancer Inst. 2005;97(22):1688-94.
    • (2005) J Natl Cancer Inst , vol.97 , Issue.22 , pp. 1688-1694
    • Wei, E.K.1    Giovannucci, E.2    Fuchs, C.S.3    Willett, W.C.4    Mantzoros, C.S.5
  • 30
    • 0041825575 scopus 로고    scopus 로고
    • Oestrogen exposure and breast cancer risk
    • Travis RC, Key TJ. Oestrogen exposure and breast cancer risk. Breast Cancer Res. 2003;5(5):239-47.
    • (2003) Breast Cancer Res , vol.5 , Issue.5 , pp. 239-247
    • Travis, R.C.1    Key, T.J.2
  • 31
    • 0346655244 scopus 로고    scopus 로고
    • Serum concentrations of IGF-I, IGFBP-3 and c-peptide and risk of hyperplasia and cancer of the breast in postmenopausal women
    • Schairer C, Hill D, Sturgeon SR, Fears T, Pollak M, Mies C, et al. Serum concentrations of IGF-I, IGFBP-3 and c-peptide and risk of hyperplasia and cancer of the breast in postmenopausal women. Int J Cancer. 2004;108(5):773-9.
    • (2004) Int J Cancer , vol.108 , Issue.5 , pp. 773-779
    • Schairer, C.1    Hill, D.2    Sturgeon, S.R.3    Fears, T.4    Pollak, M.5    Mies, C.6
  • 33
    • 0035173953 scopus 로고    scopus 로고
    • Population-based, case-control study of blood C-peptide level and breast cancer risk
    • Yang G, Lu G, Jin F, Dai Q, Best R, Shu XO, et al. Population-based, case-control study of blood C-peptide level and breast cancer risk. Cancer Epidemiol Biomarkers Prev. 2001;10(11):1207-11.
    • (2001) Cancer Epidemiol Biomarkers Prev , vol.10 , Issue.11 , pp. 1207-1211
    • Yang, G.1    Lu, G.2    Jin, F.3    Dai, Q.4    Best, R.5    Shu, X.O.6
  • 35
    • 0032499440 scopus 로고    scopus 로고
    • Circulating concentrations of insulin-like growth factor-I and risk of breast cancer
    • Hankinson SE, Willett WC, Colditz GA, Hunter DJ, Michaud DS, Deroo B, et al. Circulating concentrations of insulin-like growth factor-I and risk of breast cancer. Lancet. 1998;351(9113):1393-6.
    • (1998) Lancet , vol.351 , Issue.9113 , pp. 1393-1396
    • Hankinson, S.E.1    Willett, W.C.2    Colditz, G.A.3    Hunter, D.J.4    Michaud, D.S.5    Deroo, B.6
  • 37
    • 34547741589 scopus 로고    scopus 로고
    • Adipokines as endocrine, paracrine, and autocrine factors in breast cancer risk and progression
    • Vona-Davis L, Rose DP. Adipokines as endocrine, paracrine, and autocrine factors in breast cancer risk and progression. Endocr Relat Cancer. 2007;14(2):189-206.
    • (2007) Endocr Relat Cancer , vol.14 , Issue.2 , pp. 189-206
    • Vona-Davis, L.1    Rose, D.P.2
  • 40
    • 0036907571 scopus 로고    scopus 로고
    • Obesity, endogenous hormones, and endometrial cancer risk: A synthetic review
    • Review
    • Kaaks R, Lukanova A, Kurzer MS. Obesity, endogenous hormones, and endometrial cancer risk: a synthetic review. Cancer Epidemiol Biomarkers Prev. 2002;11(12):1531-43. Review.
    • (2002) Cancer Epidemiol Biomarkers Prev , vol.11 , Issue.12 , pp. 1531-1543
    • Kaaks, R.1    Lukanova, A.2    Kurzer, M.S.3
  • 41
    • 10744223927 scopus 로고    scopus 로고
    • Circulating levels of sex steroid hormones and risk of endometrial cancer in postmenopausal women
    • Lukanova A, Lundin E, Micheli A, Arslan A, Ferrari P, Rinaldi S, et al. Circulating levels of sex steroid hormones and risk of endometrial cancer in postmenopausal women. Int J Cancer. 2004;108(3):425-32.
    • (2004) Int J Cancer , vol.108 , Issue.3 , pp. 425-432
    • Lukanova, A.1    Lundin, E.2    Micheli, A.3    Arslan, A.4    Ferrari, P.5    Rinaldi, S.6
  • 42
  • 43
    • 0344825116 scopus 로고    scopus 로고
    • Evaluation of dietary, medical and lifestyle risk factors for incident kidney cancer in postmenopausal women
    • Nicodemus KK, Sweeney C, Folsom AR. Evaluation of dietary, medical and lifestyle risk factors for incident kidney cancer in postmenopausal women. Int J Cancer. 2004;108(1):115-21.
    • (2004) Int J Cancer , vol.108 , Issue.1 , pp. 115-121
    • Nicodemus, K.K.1    Sweeney, C.2    Folsom, A.R.3
  • 45
    • 30444438015 scopus 로고    scopus 로고
    • Body size and risk of renal cell carcinoma in the European Prospective Investigation into Cancer and Nutrition (EPIC)
    • Pischon T, Lahmann PH, Boeing H, Tjonneland A, Halkjaer J, Overvad K, et al. Body size and risk of renal cell carcinoma in the European Prospective Investigation into Cancer and Nutrition (EPIC). Int J Cancer. 2006;118(3):728-38.
    • (2006) Int J Cancer , vol.118 , Issue.3 , pp. 728-738
    • Pischon, T.1    Lahmann, P.H.2    Boeing, H.3    Tjonneland, A.4    Halkjaer, J.5    Overvad, K.6
  • 48
    • 28844487120 scopus 로고    scopus 로고
    • Epidemiology of esophageal adenocarcinoma
    • Pera M, Manterola C, Vidal O, Grande L. Epidemiology of esophageal adenocarcinoma. J Surg Oncol. 2005;92(3):151-9.
    • (2005) J Surg Oncol , vol.92 , Issue.3 , pp. 151-159
    • Pera, M.1    Manterola, C.2    Vidal, O.3    Grande, L.4
  • 49
    • 33744732468 scopus 로고    scopus 로고
    • Body mass index and adenocarcinomas of the esophagus or gastric cardia: A systematic review and metaanalysis
    • Kubo A, Corley DA. Body mass index and adenocarcinomas of the esophagus or gastric cardia: a systematic review and metaanalysis. Cancer Epidemiol Biomarkers Prev. 2006;15(5):872-8.
    • (2006) Cancer Epidemiol Biomarkers Prev , vol.15 , Issue.5 , pp. 872-878
    • Kubo, A.1    Corley, D.A.2
  • 51
    • 39449136419 scopus 로고    scopus 로고
    • Abdominal obesity and the risk of esophageal and gastric cardia carcinomas
    • Corley DA, Kubo A, Zhao W. Abdominal obesity and the risk of esophageal and gastric cardia carcinomas. Cancer Epidemiol Biomarkers Prev. 2008;17(2):352-8.
    • (2008) Cancer Epidemiol Biomarkers Prev , vol.17 , Issue.2 , pp. 352-358
    • Corley, D.A.1    Kubo, A.2    Zhao, W.3
  • 52
    • 23044493202 scopus 로고    scopus 로고
    • Meta-analysis: Obesity and the risk for gastroesophageal reflux disease and its complications
    • Hampel H, Abraham NS, El-Serag HB. Meta-analysis: obesity and the risk for gastroesophageal reflux disease and its complications. Ann Intern Med. 2005;143(3):199-211.
    • (2005) Ann Intern Med , vol.143 , Issue.3 , pp. 199-211
    • Hampel, H.1    Abraham, N.S.2    El-Serag, H.B.3
  • 53
    • 34247869042 scopus 로고    scopus 로고
    • The role of obesity and related metabolic disturbances in cancers of the colon, prostate, and pancreas
    • Giovannucci E, Michaud D. The role of obesity and related metabolic disturbances in cancers of the colon, prostate, and pancreas. Gastroenterology. 2007;132(6):2208-25.
    • (2007) Gastroenterology , vol.132 , Issue.6 , pp. 2208-2225
    • Giovannucci, E.1    Michaud, D.2
  • 55
    • 48349136530 scopus 로고    scopus 로고
    • Obesity and risk of pancreatic cancer among postmenopausal women: The Women's Health Initiative (United States)
    • Epub 2008 Jul 15
    • Luo J, Margolis KL, Adami HO, LaCroix A, Ye W. Obesity and risk of pancreatic cancer among postmenopausal women: the Women's Health Initiative (United States). Br J Cancer. 2008;99(3):527-31. Epub 2008 Jul 15.
    • (2008) Br J Cancer , vol.99 , Issue.3 , pp. 527-531
    • Luo, J.1    Margolis, K.L.2    Adami, H.O.3    laCroix, A.4    Ye, W.5
  • 56
    • 0034679058 scopus 로고    scopus 로고
    • Abnormal glucose metabolism and pancreatic cancer mortality
    • Gapstur SM, Gann PH, Lowe W, Liu K, Colangelo L, Dyer A. Abnormal glucose metabolism and pancreatic cancer mortality. JAMA. 2000;283(19):2552-8.
    • (2000) JAMA , vol.283 , Issue.19 , pp. 2552-2558
    • Gapstur, S.M.1    Gann, P.H.2    Lowe, W.3    Liu, K.4    Colangelo, L.5    Dyer, A.6
  • 57
    • 34347325203 scopus 로고    scopus 로고
    • Circulating insulin-like growth factor axis and the risk of pancreatic cancer in four prospective cohort
    • Epub 2007 May 29
    • Wolpin BM, Michaud DS, Giovannucci EL, Schernhammer ES, Stampfer MJ, Manson JE, et al. Circulating insulin-like growth factor axis and the risk of pancreatic cancer in four prospective cohort. Br J Cancer. 2007;97(1):98-104. Epub 2007 May 29.
    • (2007) Br J Cancer , vol.97 , Issue.1 , pp. 98-104
    • Wolpin, B.M.1    Michaud, D.S.2    Giovannucci, E.L.3    Schernhammer, E.S.4    Stampfer, M.J.5    Manson, J.E.6
  • 58
    • 33747883049 scopus 로고    scopus 로고
    • Body size and composition and prostate cancer risk: Systematic review and meta-regression analysis
    • MacInnis RJ, English DR. Body size and composition and prostate cancer risk: systematic review and meta-regression analysis. Cancer Causes Control. 2006;17(8):989-1003.
    • (2006) Cancer Causes Control , vol.17 , Issue.8 , pp. 989-1003
    • MacInnis, R.J.1    English, D.R.2
  • 59
    • 0029882353 scopus 로고    scopus 로고
    • Reversal of relation between body mass and endogenous estrogen concentrations with menopausal status
    • Potischman N, Swanson CA, Siiteri P, Hoover RN. Reversal of relation between body mass and endogenous estrogen concentrations with menopausal status. J Natl Cancer Inst. 1996;88(11):756-8.
    • (1996) J Natl Cancer Inst , vol.88 , Issue.11 , pp. 756-758
    • Potischman, N.1    Swanson, C.A.2    Siiteri, P.3    Hoover, R.N.4
  • 60
    • 0032559272 scopus 로고    scopus 로고
    • Plasma insulin-like growth factor-I and prostate cancer risk: A prospective study
    • Chan JM, Stampfer MJ, Giovannucci E, Gann PH, Ma J, Wilkinson P, et al. Plasma insulin-like growth factor-I and prostate cancer risk: a prospective study. Science. 1998;279(5350):563-6.
    • (1998) Science , vol.279 , Issue.5350 , pp. 563-566
    • Chan, J.M.1    Stampfer, M.J.2    Giovannucci, E.3    Gann, P.H.4    Ma, J.5    Wilkinson, P.6
  • 61
    • 34247578216 scopus 로고    scopus 로고
    • Obesity and the risk of gallbladder cancer: A meta-analysis
    • Larsson SC, Wolk A. Obesity and the risk of gallbladder cancer: a meta-analysis. Br J Cancer. 2007;96(9):1457-61.
    • (2007) Br J Cancer , vol.96 , Issue.9 , pp. 1457-1461
    • Larsson, S.C.1    Wolk, A.2
  • 64
    • 4043139452 scopus 로고    scopus 로고
    • Body size and breast cancer risk: Findings from the European Prospective Investigation into Cancer and Nutrition (EPIC)
    • Lahmann PH, Hoffmann K, Allen N, van Gils CH, Khaw KT, Tehard B, et al. Body size and breast cancer risk: findings from the European Prospective Investigation into Cancer and Nutrition (EPIC). Int J Cancer. 2004;111(5):762-71.
    • (2004) Int J Cancer , vol.111 , Issue.5 , pp. 762-771
    • Lahmann, P.H.1    Hoffmann, K.2    Allen, N.3    van Gils, C.H.4    Khaw, K.T.5    Tehard, B.6
  • 65
    • 33947704799 scopus 로고    scopus 로고
    • Obesity and the risk of epithelial ovarian cancer: A systematic review and meta-analysis
    • Epub 2007 Jan 12
    • Olsen CM, Green AC, Whiteman DC, Sadeghi S, Kolahdooz F, Webb PM. Obesity and the risk of epithelial ovarian cancer: a systematic review and meta-analysis. Eur J Cancer. 2007;43(4):690-709. Epub 2007 Jan 12.
    • (2007) Eur J Cancer , vol.43 , Issue.4 , pp. 690-709
    • Olsen, C.M.1    Green, A.C.2    Whiteman, D.C.3    Sadeghi, S.4
  • 66
    • 44949133008 scopus 로고    scopus 로고
    • Body size and risk of epithelial ovarian and related cancers: A population-based case-control study
    • Olsen CM, Nagle CM, Whiteman DC, Purdie DM, Green AC, Webb PM. Body size and risk of epithelial ovarian and related cancers: a population-based case-control study. Int J Cancer. 2008;123(2):450-6.
    • (2008) Int J Cancer , vol.123 , Issue.2 , pp. 450-456
    • Olsen, C.M.1    Nagle, C.M.2    Whiteman, D.C.3    Purdie, D.M.4    Green, A.C.5    Webb, P.M.6
  • 67
    • 33845885799 scopus 로고    scopus 로고
    • Height and body mass index and risk of lymphohematopoietic malignancies in two million Norwegian men and women
    • Epub 2006 Oct 13
    • Engeland A, Tretli S, Hansen S, Bjørge T. Height and body mass index and risk of lymphohematopoietic malignancies in two million Norwegian men and women. Am J Epidemiol. 2007;165(1):44-52. Epub 2006 Oct 13.
    • (2007) Am J Epidemiol , vol.165 , Issue.1 , pp. 44-52
    • Engeland, A.1    Tretli, S.2    Hansen, S.3    Bjørge, T.4
  • 68
    • 35648967485 scopus 로고    scopus 로고
    • Body mass index and risk of multiple myeloma: A meta-analysis
    • Larsson SC, Wolk A. Body mass index and risk of multiple myeloma: a meta-analysis. Int J Cancer. 2007;121(11):2512-6.
    • (2007) Int J Cancer , vol.121 , Issue.11 , pp. 2512-2516
    • Larsson, S.C.1    Wolk, A.2
  • 69
    • 4344623889 scopus 로고    scopus 로고
    • Imatinib as a paradigm of targeted therapies
    • Druker BJ. Imatinib as a paradigm of targeted therapies. Adv Cancer Res. 2004;91:1-30.
    • (2004) Adv Cancer Res , vol.91 , pp. 1-30
    • Druker, B.J.1
  • 70
    • 0028113617 scopus 로고
    • Epidemiology of colorectal cancer revisited: Are serum triglycerides and/or plasma glucose associated with risk?
    • McKeown-Eyssen G. Epidemiology of colorectal cancer revisited: are serum triglycerides and/or plasma glucose associated with risk? Cancer Epidemiol Biomarkers Prev. 1994;3(8):687-95.
    • (1994) Cancer Epidemiol Biomarkers Prev , vol.3 , Issue.8 , pp. 687-695
    • McKeown-Eyssen, G.1
  • 71
    • 0028987002 scopus 로고
    • Insulin and colon cancer
    • Review
    • Giovannucci E. Insulin and colon cancer. Cancer Causes Control. 1995;6(2):164-79. Review.
    • (1995) Cancer Causes Control , vol.6 , Issue.2 , pp. 164-179
    • Giovannucci, E.1
  • 72
    • 0346725867 scopus 로고    scopus 로고
    • Nutrition, insulin, insulin-like growth factors and cancer
    • Giovannucci E. Nutrition, insulin, insulin-like growth factors and cancer. Horm Metab Res. 2003;35(11-12):694-704.
    • (2003) Horm Metab Res , vol.35 , Issue.11-12 , pp. 694-704
    • Giovannucci, E.1
  • 73
    • 3543072186 scopus 로고    scopus 로고
    • Overweight, obesity and cancer: Epidemiological evidence and proposed mechanisms
    • Calle EE, Kaaks R. Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms. Nat Rev Cancer.2004;4(8):579-91.
    • (2004) Nat Rev Cancer , vol.4 , Issue.8 , pp. 579-591
    • Calle, E.E.1    Kaaks, R.2
  • 74
    • 0037305130 scopus 로고    scopus 로고
    • Lifestyle determinants of serum insulin-like growth-factor-I (IGF-I), C-peptide and hormone binding protein levels in British women
    • Allen NE, Appleby PN, Kaaks R, Rinaldi S, Davey GK, Key TJ. Lifestyle determinants of serum insulin-like growth-factor-I (IGF-I), C-peptide and hormone binding protein levels in British women. Cancer Causes Control. 2003;14(1):65-74.
    • (2003) Cancer Causes Control , vol.14 , Issue.1 , pp. 65-74
    • Allen, N.E.1    Appleby, P.N.2    Kaaks, R.3    Rinaldi, S.4    Davey, G.K.5    Key, T.J.6
  • 75
    • 0036716967 scopus 로고    scopus 로고
    • Lifestyle correlates of plasma insulin-like growth factor I and insulin-like growth factor binding protein 3 concentrations
    • Holmes MD, Pollak MN, Hankinson SE. Lifestyle correlates of plasma insulin-like growth factor I and insulin-like growth factor binding protein 3 concentrations. Cancer Epidemiol Biomarkers Prev. 2002;11(9):862-7.
    • (2002) Cancer Epidemiol Biomarkers Prev , vol.11 , Issue.9 , pp. 862-867
    • Holmes, M.D.1    Pollak, M.N.2    Hankinson, S.E.3
  • 76
    • 0021718287 scopus 로고
    • Receptor binding and growth-promoting activity of insulin-like growth factors in human breast cancer cells (T-47D) in culture
    • Myal Y, Shiu RP, Bhaumick B, Bala M. Receptor binding and growth-promoting activity of insulin-like growth factors in human breast cancer cells (T-47D) in culture. Cancer Res. 1984;44(12 Pt 1):5486-90.
    • (1984) Cancer Res , vol.44 , Issue.12 PART. 1 , pp. 5486-5490
    • Myal, Y.1    Shiu, R.P.2    Bhaumick, B.3    Bala, M.4
  • 77
    • 0042090507 scopus 로고    scopus 로고
    • Reduced circulating insulin-like growth factor I levels delay the onset of chemically and genetically induced mammary tumors
    • Wu Y, Cui K, Miyoshi K, Hennighausen L, Green JE, Setser J, et al. Reduced circulating insulin-like growth factor I levels delay the onset of chemically and genetically induced mammary tumors. Cancer Res. 2003;63(15):4384-8.
    • (2003) Cancer Res , vol.63 , Issue.15 , pp. 4384-4388
    • Wu, Y.1    Cui, K.2    Miyoshi, K.3    Hennighausen, L.4    Green, J.E.5    Setser, J.6
  • 78
    • 0035800512 scopus 로고    scopus 로고
    • Reduced mammary gland carcinogenesis in transgenic mice expressing a growth hormone antagonist
    • Pollak M, Blouin MJ, Zhang JC, Kopchick JJ. Reduced mammary gland carcinogenesis in transgenic mice expressing a growth hormone antagonist. Br J Cancer. 2001;85(3):428-30.
    • (2001) Br J Cancer , vol.85 , Issue.3 , pp. 428-430
    • Pollak, M.1    Blouin, M.J.2    Zhang, J.C.3    Kopchick, J.J.4
  • 79
    • 51649091930 scopus 로고    scopus 로고
    • Insulin-like growth factor-I activates gene transcription programs strongly associated with poor breast cancer prognosis
    • Creighton CJ, Casa A, Lazard Z, Huang S, Tsimelzon A, Hilsenbeck SG, et al. Insulin-like growth factor-I activates gene transcription programs strongly associated with poor breast cancer prognosis. J Clin Oncol. 2008;26:4078-85.
    • (2008) J Clin Oncol , vol.26 , pp. 4078-4085
    • Creighton, C.J.1    Casa, A.2    Lazard, Z.3    Huang, S.4    Tsimelzon, A.5    Hilsenbeck, S.G.6
  • 81
    • 56549109059 scopus 로고    scopus 로고
    • Dietary energy balance modulates signaling through the akt/mammalian target of rapamycin pathways in multiple epithelial tissues
    • Epub 2008 Mar 31
    • Moore T, Beltran L, Carbajal S, Strom S, Traag J, Hursting SD, et al. Dietary energy balance modulates signaling through the akt/mammalian target of rapamycin pathways in multiple epithelial tissues. Cancer Prev Res. 2008;1(1):65-76. Epub 2008 Mar 31.
    • (2008) Cancer Prev Res , vol.1 , Issue.1 , pp. 65-76
    • Moore, T.1    Beltran, L.2    Carbajal, S.3    Strom, S.4    Traag, J.5    Hursting, S.D.6
  • 82
    • 0037205048 scopus 로고    scopus 로고
    • The phosphoinositide 3-kinase pathway
    • Cantley LC. The phosphoinositide 3-kinase pathway. Science.2002;296(5573):1655-7.
    • (2002) Science , vol.296 , Issue.5573 , pp. 1655-1657
    • Cantley, L.C.1
  • 83
    • 0036713778 scopus 로고    scopus 로고
    • TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
    • Inoki K, Li Y, Zhu T, Wu J, Guan KL. TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat Cell Biol. 2002;4(9):648-57.
    • (2002) Nat Cell Biol , vol.4 , Issue.9 , pp. 648-657
    • Inoki, K.1    li, Y.2    Zhu, T.3    Wu, J.4    Guan, K.L.5
  • 84
    • 0038433304 scopus 로고    scopus 로고
    • Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2
    • Garami A, Zwartkruis FJ, Nobukuni T, Joaquin M, Roccio M, Stocker H, et al. Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2. Mol Cell. 2003;11(6):1457-66.
    • (2003) Mol Cell , vol.11 , Issue.6 , pp. 1457-1466
    • Garami, A.1    Zwartkruis, F.J.2    Nobukuni, T.3    Joaquin, M.4    Roccio, M.5    Stocker, H.6
  • 85
    • 4043171462 scopus 로고    scopus 로고
    • Upstream and downstream of mTOR
    • Hay N, Sonenberg N. Upstream and downstream of mTOR. Genes Dev. 2004;18(16):1926-45.
    • (2004) Genes Dev , vol.18 , Issue.16 , pp. 1926-1945
    • Hay, N.1    Sonenberg, N.2
  • 86
    • 0036712741 scopus 로고    scopus 로고
    • TSC1-TSC2: A complex tale of PKB-mediated S6K regulation
    • McManus EJ, Alessi DR. TSC1-TSC2: a complex tale of PKB-mediated S6K regulation. Nat Cell Biol. 2002;4(9):E214-6.
    • (2002) Nat Cell Biol , vol.4 , Issue.9
    • McManus, E.J.1    Alessi, D.R.2
  • 87
    • 4544384577 scopus 로고    scopus 로고
    • Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase
    • Epub 2004 Sep 1
    • Roux PP, Ballif BA, Anjum R, Gygi SP, Blenis J. Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase. Proc Natl Acad Sci U S A. 2004;101(37):13489-94. Epub 2004 Sep 1.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , Issue.37 , pp. 13489-13494
    • Roux, P.P.1    Ballif, B.A.2    Anjum, R.3    Gygi, S.P.4    Blenis, J.5
  • 88
    • 0345167800 scopus 로고    scopus 로고
    • TSC2 mediates cellular energy response to control cell growth and survival
    • Inoki K, Zhu T, Guan KL. TSC2 mediates cellular energy response to control cell growth and survival. Cell. 2003;115(5):577-90.
    • (2003) Cell , vol.115 , Issue.5 , pp. 577-590
    • Inoki, K.1    Zhu, T.2    Guan, K.L.3
  • 89
    • 11844304072 scopus 로고    scopus 로고
    • Restraining PI3K: MTOR signalling goes back to the membrane
    • Harrington LS, Findlay GM, Lamb RF. Restraining PI3K: mTOR signalling goes back to the membrane. Trends Biochem Sci. 2005;30(1):35-42.
    • (2005) Trends Biochem Sci , vol.30 , Issue.1 , pp. 35-42
    • Harrington, L.S.1    Findlay, G.M.2    Lamb, R.F.3
  • 91
    • 85047695528 scopus 로고    scopus 로고
    • Hsp-90-associated oncoproteins: Multiple targets of geldanamycin and its analogs
    • Blagosklonny MV. Hsp-90-associated oncoproteins: multiple targets of geldanamycin and its analogs. Leukemia. 2002;16(4):455-62.
    • (2002) Leukemia , vol.16 , Issue.4 , pp. 455-462
    • Blagosklonny, M.V.1
  • 93
    • 30944447568 scopus 로고    scopus 로고
    • The extracellular signal-regulated kinase: Multiple substrates regulate diverse cellular functions
    • Yoon S, Seger R. The extracellular signal-regulated kinase: multiple substrates regulate diverse cellular functions. Growth Factors. 2006;24(1):21-44.
    • (2006) Growth Factors , vol.24 , Issue.1 , pp. 21-44
    • Yoon, S.1    Seger, R.2
  • 94
    • 33646336602 scopus 로고    scopus 로고
    • MAPK signal specificity: The right place at the right time
    • Epub 2006 Apr 17
    • Murphy LO, Blenis J. MAPK signal specificity: the right place at the right time. Trends Biochem Sci. 2006;31(5):268-75. Epub 2006 Apr 17.
    • (2006) Trends Biochem Sci , vol.31 , Issue.5 , pp. 268-275
    • Murphy, L.O.1    Blenis, J.2
  • 98
    • 0032839757 scopus 로고    scopus 로고
    • Estradiol induction of cAMP in breast cancer cells is mediated by foetal calf serum (FCS) and sex hormone-binding globulin (SHBG)
    • Fortunati N, Fissore F, Fazzari A, Piovano F, Catalano MG, Becchis M, et al. Estradiol induction of cAMP in breast cancer cells is mediated by foetal calf serum (FCS) and sex hormone-binding globulin (SHBG). J Steroid Biochem Mol Biol. 1999;70(1-3):73-80.
    • (1999) J Steroid Biochem Mol Biol , vol.70 , Issue.1-3 , pp. 73-80
    • Fortunati, N.1    Fissore, F.2    Fazzari, A.3    Piovano, F.4    Catalano, M.G.5    Becchis, M.6
  • 99
    • 0030071520 scopus 로고    scopus 로고
    • Sex steroid binding protein exerts a negative control on estradiol action in MCF-7 cells (human breast cancer) through cyclic adenosine 3′,5′-monophosphate and protein kinase A
    • Fortunati N, Fissore F, Fazzari A, Becchis M, Comba A, Catalano MG, et al. Sex steroid binding protein exerts a negative control on estradiol action in MCF-7 cells (human breast cancer) through cyclic adenosine 3′,5′-monophosphate and protein kinase A. Endocrinology. 1996;137(2):686-92.
    • (1996) Endocrinology , vol.137 , Issue.2 , pp. 686-692
    • Fortunati, N.1    Fissore, F.2    Fazzari, A.3    Becchis, M.4    Comba, A.5    Catalano, M.G.6
  • 100
    • 12344265008 scopus 로고    scopus 로고
    • Sex hormone-binding globulin antagonizes the anti-apoptotic effect of estradiol in breast cancer cells
    • Catalano MG, Frairia R, Boccuzzi G, Fortunati N. Sex hormone-binding globulin antagonizes the anti-apoptotic effect of estradiol in breast cancer cells. Mol Cell Endocrinol. 2005;230(1-2):31-7.
    • (2005) Mol Cell Endocrinol , vol.230 , Issue.1-2 , pp. 31-37
    • Catalano, M.G.1    Frairia, R.2    Boccuzzi, G.3    Fortunati, N.4
  • 101
    • 0033305004 scopus 로고    scopus 로고
    • Enhancement of insulin-like growth factor signaling in human breast cancer: Estrogen regulation of insulin receptor substrate-1 expression in vitro and in vivo
    • Lee AV, Jackson JG, Gooch JL, Hilsenbeck SG, Coronado-Heinsohn E, Osborne CK, et al. Enhancement of insulin-like growth factor signaling in human breast cancer: estrogen regulation of insulin receptor substrate-1 expression in vitro and in vivo. Mol Endocrinol. 1999;13(5):787-96.
    • (1999) Mol Endocrinol , vol.13 , Issue.5 , pp. 787-796
    • Lee, A.V.1    Jackson, J.G.2    Gooch, J.L.3    Hilsenbeck, S.G.4    Coronado-Heinsohn, E.5    Osborne, C.K.6
  • 102
    • 0031456016 scopus 로고    scopus 로고
    • Insulin resistance and the polycystic ovary syndrome: Mechanism and implications for pathogenesis
    • Dunaif A. Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis. Endocr Rev. 1997;18(6):774-800.
    • (1997) Endocr Rev , vol.18 , Issue.6 , pp. 774-800
    • Dunaif, A.1
  • 103
    • 85047696604 scopus 로고
    • Polycystic ovary syndrome as a form of functional ovarian hyperandrogenism due to dysregulation of androgen secretion
    • Review
    • Ehrmann DA, Barnes RB, Rosenfield RL. Polycystic ovary syndrome as a form of functional ovarian hyperandrogenism due to dysregulation of androgen secretion. Endocr Rev. 1995;16(3):322-53. Review.
    • (1995) Endocr Rev , vol.16 , Issue.3 , pp. 322-353
    • Ehrmann, D.A.1    Barnes, R.B.2    Rosenfield, R.L.3
  • 104
    • 0037090527 scopus 로고    scopus 로고
    • IGF-1 in gynaecology and obstetrics: Update 2002
    • Druckmann R, Rohr UD. IGF-1 in gynaecology and obstetrics: update 2002. Maturitas. 2002;41 Suppl 1:S65-83.
    • (2002) Maturitas , vol.41 , Issue.SUPPL. 1
    • Druckmann, R.1    Rohr, U.D.2
  • 106
    • 9144256614 scopus 로고    scopus 로고
    • Cross-talk between estrogen receptor and growth factor pathways as a molecular target for overcoming endocrine resistance
    • Schiff R, Massarweh SA, Shou J, Bharwani L, Mohsin SK, Osborne CK. Cross-talk between estrogen receptor and growth factor pathways as a molecular target for overcoming endocrine resistance. Clin Cancer Res. 2004;10(1 Pt2):S331-6.
    • (2004) Clin Cancer Res , vol.10 , Issue.1 PART. 2
    • Schiff, R.1    Massarweh, S.A.2    Shou, J.3    Bharwani, L.4    Mohsin, S.K.5    Osborne, C.K.6
  • 107
    • 0035901090 scopus 로고    scopus 로고
    • Inflammation and cancer: Back to Virchow?
    • Balkwill F, Mantovani A. Inflammation and cancer: back to Virchow? Lancet. 2001;357(9255):539-45.
    • (2001) Lancet , vol.357 , Issue.9255 , pp. 539-545
    • Balkwill, F.1    Mantovani, A.2
  • 108
    • 0037569704 scopus 로고    scopus 로고
    • The epidemiology of gastric cancer
    • Roder DM. The epidemiology of gastric cancer. Gastric Cancer. 2002;5 Suppl 1:5-11.
    • (2002) Gastric Cancer , vol.5 , Issue.SUPPL. 1 , pp. 5-11
    • Roder, D.M.1
  • 109
    • 0032107143 scopus 로고    scopus 로고
    • Risk of cancer in ulcerative colitis
    • Review
    • Ekbom A. Risk of cancer in ulcerative colitis. J Gastrointest Surg. 1998;2(4):312-3. Review.
    • (1998) J Gastrointest Surg , vol.2 , Issue.4 , pp. 312-313
    • Ekbom, A.1
  • 110
    • 4644359517 scopus 로고    scopus 로고
    • Respiratory health consequences of environmental tobacco smoke
    • Dhala A, Pinsker K, Prezant DJ. Respiratory health consequences of environmental tobacco smoke. Med Clin North Am. 2004;88(6):1535-52, xi.
    • (2004) Med Clin North Am , vol.88 , Issue.6
    • Dhala, A.1    Pinsker, K.2    Prezant, D.J.3
  • 111
    • 0027459878 scopus 로고
    • Adipose expression of tumor necrosis factor-alpha: Direct role in obesity-linked insulin resistance
    • Hotamisligil GS, Shargill NS, Spiegelman BM. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science. 1993;259(5091):87-91.
    • (1993) Science , vol.259 , Issue.5091 , pp. 87-91
    • Hotamisligil, G.S.1    Shargill, N.S.2    Spiegelman, B.M.3
  • 112
    • 34547602916 scopus 로고    scopus 로고
    • Loss-of-function mutation in Toll-like receptor 4 prevents diet-induced obesity and insulin resistance
    • Epub 2007 May 22
    • Tsukumo DM, Carvalho-Filho MA, Carvalheira JB, Prada PO, Hirabara SM, Schenka AA, et al. Loss-of-function mutation in Toll-like receptor 4 prevents diet-induced obesity and insulin resistance.Diabetes. 2007;56(8):1986-98. Epub 2007 May 22.
    • (2007) Diabetes , vol.56 , Issue.8 , pp. 1986-1998
    • Tsukumo, D.M.1    Carvalho-Filho, M.A.2    Carvalheira, J.B.3    Prada, P.O.4    Hirabara, S.M.5    Schenka, A.A.6
  • 113
    • 0037424466 scopus 로고    scopus 로고
    • Modulation of insulin-stimulated degradation of human insulin receptor substrate-1 by Serine 312 phosphorylation
    • Epub 2003 Jan 1
    • Greene MW, Sakaue H, Wang L, Alessi DR, Roth RA. Modulation of insulin-stimulated degradation of human insulin receptor substrate-1 by Serine 312 phosphorylation. J Biol Chem. 2003;278(10):8199-211. Epub 2003 Jan 1.
    • (2003) J Biol Chem , vol.278 , Issue.10 , pp. 8199-8211
    • Greene, M.W.1    Sakaue, H.2    Wang, L.3    Alessi, D.R.4    Roth, R.A.5
  • 114
    • 0037059330 scopus 로고    scopus 로고
    • Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action
    • Epub 2001 Oct 17
    • Aguirre V, Werner ED, Giraud J, Lee YH, Shoelson SE, White MF. Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action. J Biol Chem. 2002;277(2):1531-7. Epub 2001 Oct 17.
    • (2002) J Biol Chem , vol.277 , Issue.2 , pp. 1531-1537
    • Aguirre, V.1    Werner, E.D.2    Giraud, J.3    Lee, Y.H.4    Shoelson, S.E.5    White, M.F.6
  • 115
    • 4043088499 scopus 로고    scopus 로고
    • IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer
    • Greten FR, Eckmann L, Greten TF, Park JM, Li ZW, Egan LJ, et al. IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer. Cell. 2004;118(3):285-96.
    • (2004) Cell , vol.118 , Issue.3 , pp. 285-296
    • Greten, F.R.1    Eckmann, L.2    Greten, T.F.3    Park, J.M.4    li, Z.W.5    Egan, L.J.6
  • 116
    • 21244472975 scopus 로고    scopus 로고
    • IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis
    • Maeda S, Kamata H, Luo JL, Leffert H, Karin M. IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis. Cell. 2005;121(7):977-90.
    • (2005) Cell , vol.121 , Issue.7 , pp. 977-990
    • Maeda, S.1    Kamata, H.2    Luo, J.L.3    Leffert, H.4    Karin, M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.