-
1
-
-
38649125625
-
Rumi is a CAP10 domain glycosyltransferase that modifies Notch and is required for Notch signaling
-
Acar M, Jafar-Nejad H, Takeuchi H, Rajan A, Ibrani D, Rana NA, Pan H, Haltiwanger RS, Bellen HJ (2008) Rumi is a CAP10 domain glycosyltransferase that modifies Notch and is required for Notch signaling. Cell 132(2):247–258. https://doi.org/10.1016/j. cell.2007.12.016
-
(2008)
Cell
, vol.132
, Issue.2
, pp. 247-258
-
-
Acar, M.1
Jafar-Nejad, H.2
Takeuchi, H.3
Rajan, A.4
Ibrani, D.5
Rana, N.A.6
Pan, H.7
Haltiwanger, R.S.8
Bellen, H.J.9
-
2
-
-
84860811239
-
Tandem mass spectrometry identifies many mouse brain O-GlcNAcylated proteins including EGF domain-specific O-GlcNAc transferase targets
-
Alfaro JF, Gong CX, Monroe ME, Aldrich JT, Clauss TR, Purvine SO, Wang Z, Camp DG 2nd, Shabanowitz J, Stanley P, Hart GW, Hunt DF, Yang F, Smith RD (2012) Tandem mass spectrometry identifies many mouse brain O-GlcNAcylated proteins including EGF domain-specific O-GlcNAc transferase targets. Proc Natl Acad Sci U S A 109(19):7280–7285. https://doi. org/10.1073/pnas.1200425109
-
(2012)
Proc Natl Acad Sci U S A
, vol.109
, Issue.19
, pp. 7280-7285
-
-
Alfaro, J.F.1
Gong, C.X.2
Monroe, M.E.3
Aldrich, J.T.4
Clauss, T.R.5
Purvine, S.O.6
Wang, Z.7
Camp, D.G.8
Shabanowitz, J.9
Stanley, P.10
Hart, G.W.11
Hunt, D.F.12
Yang, F.13
Smith, R.D.14
-
3
-
-
84883436417
-
Intrinsic selectivity of Notch 1 for Delta-like 4 over Delta-like 1
-
Andrawes MB, Xu X, Liu H, Ficarro SB, Marto JA, Aster JC, Blacklow SC (2013) Intrinsic selectivity of Notch 1 for Delta-like 4 over Delta-like 1. J Biol Chem 288(35):25477–25489. https://doi.org/10.1074/jbc. M113.454850
-
(2013)
J Biol Chem
, vol.288
, Issue.35
, pp. 25477-25489
-
-
Andrawes, M.B.1
Xu, X.2
Liu, H.3
Ficarro, S.B.4
Marto, J.A.5
Aster, J.C.6
Blacklow, S.C.7
-
4
-
-
0030977266
-
Growth retardation and early death of beta-1,4-galactosyltransferase knockout mice with augmented proliferation and abnormal dif-ferentiation of epithelial cells
-
Asano M, Furukawa K, Kido M, Matsumoto S, Umesaki Y, Kochibe N, Iwakura Y (1997) Growth retardation and early death of beta-1,4-galactosyltransferase knockout mice with augmented proliferation and abnormal dif-ferentiation of epithelial cells. EMBO J 16(8):1850– 1857. https://doi.org/10.1093/emboj/16.8.1850
-
(1997)
EMBO J
, vol.16
, Issue.8
, pp. 1850-1857
-
-
Asano, M.1
Furukawa, K.2
Kido, M.3
Matsumoto, S.4
Umesaki, Y.5
Kochibe, N.6
Iwakura, Y.7
-
6
-
-
84891758862
-
Mutations in POGLUT1, encoding protein O-glucosyltransferase 1, cause autosomal-dominant Dowling-Degos disease
-
Basmanav FB, Oprisoreanu AM, Pasternack SM, Thiele H, Fritz G, Wenzel J, Grosser L, Wehner M, Wolf S, Fagerberg C, Bygum A, Altmuller J, Rutten A, Parmentier L, El Shabrawi-Caelen L, Hafner C, Nurnberg P, Kruse R, Schoch S, Hanneken S, Betz RC (2014) Mutations in POGLUT1, encoding protein O-glucosyltransferase 1, cause autosomal-dominant Dowling-Degos disease. Am J Hum Genet 94(1):135– 143. https://doi.org/10.1016/j.ajhg.2013.12.003
-
(2014)
Am J Hum Genet
, vol.94
, Issue.1
, pp. 135-143
-
-
Basmanav, F.B.1
Oprisoreanu, A.M.2
Pasternack, S.M.3
Thiele, H.4
Fritz, G.5
Wenzel, J.6
Grosser, L.7
Wehner, M.8
Wolf, S.9
Fagerberg, C.10
Bygum, A.11
Altmuller, J.12
Rutten, A.13
Parmentier, L.14
El Shabrawi-Caelen, L.15
Hafner, C.16
Nurnberg, P.17
Kruse, R.18
Schoch, S.19
Hanneken, S.20
Betz, R.C.21
more..
-
7
-
-
66449123068
-
The notch ligands Dll4 and Jagged1 have opposing effects on angiogenesis
-
Benedito R, Roca C, Sorensen I, Adams S, Gossler A, Fruttiger M, Adams RH (2009) The notch ligands Dll4 and Jagged1 have opposing effects on angiogenesis. Cell 137(6):1124–1135. https://doi.org/10.1016/j. cell.2009.03.025
-
(2009)
Cell
, vol.137
, Issue.6
, pp. 1124-1135
-
-
Benedito, R.1
Roca, C.2
Sorensen, I.3
Adams, S.4
Gossler, A.5
Fruttiger, M.6
Adams, R.H.7
-
8
-
-
33747623018
-
Notch signalling: A simple pathway becomes complex
-
Bray SJ (2006) Notch signalling: a simple pathway becomes complex. Nat Rev Mol Cell Biol 7(9):678– 689. https://doi.org/10.1038/nrm2009
-
(2006)
Nat Rev Mol Cell Biol
, vol.7
, Issue.9
, pp. 678-689
-
-
Bray, S.J.1
-
9
-
-
0242593940
-
Glycosyltransferase activity of Fringe modulates Notch-Delta interactions
-
Bruckner K, Perez L, Clausen H, Cohen S (2000) Glycosyltransferase activity of Fringe modulates Notch-Delta interactions. Nature 406(6794):411–415. https://doi.org/10.1038/35019075
-
(2000)
Nature
, vol.406
, Issue.6794
, pp. 411-415
-
-
Bruckner, K.1
Perez, L.2
Clausen, H.3
Cohen, S.4
-
10
-
-
0035923524
-
Fringe modulation of Jagged1-induced Notch signaling requires the action of beta 4galactosyltransferase-1
-
Chen J, Moloney DJ, Stanley P (2001) Fringe modulation of Jagged1-induced Notch signaling requires the action of beta 4galactosyltransferase-1. Proc Natl Acad Sci U S A 98(24):13716–13721. https://doi. org/10.1073/pnas.241398098
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, Issue.24
, pp. 13716-13721
-
-
Chen, J.1
Moloney, D.J.2
Stanley, P.3
-
11
-
-
33344454514
-
Expression of Notch signaling pathway genes in mouse embryos lacking beta4galactosyltransferase-1
-
Chen J, Lu L, Shi S, Stanley P (2006) Expression of Notch signaling pathway genes in mouse embryos lacking beta4galactosyltransferase-1. Gene Expr Patterns 6(4):376–382. https://doi.org/10.1016/j. modgep.2005.09.009
-
(2006)
Gene Expr Patterns
, vol.6
, Issue.4
, pp. 376-382
-
-
Chen, J.1
Lu, L.2
Shi, S.3
Stanley, P.4
-
12
-
-
84925425054
-
Analysis of POFUT1 gene mutation in a Chinese family with Dowling-Degos disease
-
Chen M, Li Y, Liu H, Fu X, Yu Y, Yu G, Wang C, Bao F, Liany H, Wang Z, Shi Z, Zhang D, Zhou G, Liu J, Zhang F (2014) Analysis of POFUT1 gene mutation in a Chinese family with Dowling-Degos disease. PLoS One 9(8):e104496. https://doi.org/10.1371/journal. pone.0104496
-
(2014)
Plos One
, vol.9
, Issue.8
-
-
Chen, M.1
Li, Y.2
Liu, H.3
Fu, X.4
Yu, Y.5
Yu, G.6
Wang, C.7
Bao, F.8
Liany, H.9
Wang, Z.10
Shi, Z.11
Zhang, D.12
Zhou, G.13
Liu, J.14
Zhang, F.15
-
13
-
-
84861995097
-
Notch receptor-ligand binding and activation: Insights from molecular studies
-
Chillakuri CR, Sheppard D, Lea SM, Handford PA (2012) Notch receptor-ligand binding and activation: insights from molecular studies. Semin Cell Dev Biol 23(4):421–428. https://doi.org/10.1016/j. semcdb.2012.01.009
-
(2012)
Semin Cell Dev Biol
, vol.23
, Issue.4
, pp. 421-428
-
-
Chillakuri, C.R.1
Sheppard, D.2
Lea, S.M.3
Handford, P.A.4
-
14
-
-
84888422328
-
Structural analysis uncovers lipid-binding properties of Notch ligands
-
Chillakuri CR, Sheppard D, Ilagan MX, Holt LR, Abbott F, Liang S, Kopan R, Handford PA, Lea SM (2013) Structural analysis uncovers lipid-binding properties of Notch ligands. Cell Rep 5(4):861–867. https://doi. org/10.1016/j.celrep.2013.10.029
-
(2013)
Cell Rep
, vol.5
, Issue.4
, pp. 861-867
-
-
Chillakuri, C.R.1
Sheppard, D.2
Ilagan, M.X.3
Holt, L.R.4
Abbott, F.5
Liang, S.6
Kopan, R.7
Handford, P.A.8
Lea, S.M.9
-
15
-
-
84894330006
-
Autosomal recessive Adams-Oliver syndrome caused by homozygous mutation in EOGT, encoding an EGF domain-specific O-GlcNAc transferase
-
Cohen I, Silberstein E, Perez Y, Landau D, Elbedour K, Langer Y, Kadir R, Volodarsky M, Sivan S, Narkis G, Birk OS (2014) Autosomal recessive Adams-Oliver syndrome caused by homozygous mutation in EOGT, encoding an EGF domain-specific O-GlcNAc transferase. Eur J Hum Genet 22(3):374–378. https://doi. org/10.1038/ejhg.2013.159
-
(2014)
Eur J Hum Genet
, vol.22
, Issue.3
, pp. 374-378
-
-
Cohen, I.1
Silberstein, E.2
Perez, Y.3
Landau, D.4
Elbedour, K.5
Langer, Y.6
Kadir, R.7
Volodarsky, M.8
Sivan, S.9
Narkis, G.10
Birk, O.S.11
-
16
-
-
49449094586
-
A conserved face of the Jagged/Serrate DSL domain is involved in Notch trans-activation and cis-inhibition
-
Cordle J, Johnson S, Tay JZ, Roversi P, Wilkin MB, de Madrid BH, Shimizu H, Jensen S, Whiteman P, Jin B, Redfield C, Baron M, Lea SM, Handford PA (2008) A conserved face of the Jagged/Serrate DSL domain is involved in Notch trans-activation and cis-inhibition. Nat Struct Mol Biol 15(8):849–857. https://doi. org/10.1038/nsmb.1457
-
(2008)
Nat Struct Mol Biol
, vol.15
, Issue.8
, pp. 849-857
-
-
Cordle, J.1
Johnson, S.2
Tay, J.Z.3
Roversi, P.4
Wilkin, M.B.5
de Madrid, B.H.6
Shimizu, H.7
Jensen, S.8
Whiteman, P.9
Jin, B.10
Redfield, C.11
Baron, M.12
Lea, S.M.13
Handford, P.A.14
-
17
-
-
84951316975
-
Sequential Notch activation regulates ventricular chamber development
-
D'Amato G, Luxan G, del Monte-Nieto G, Martinez-Poveda B, Torroja C, Walter W, Bochter MS, Benedito R, Cole S, Martinez F, Hadjantonakis AK, Uemura A, Jimenez-Borreguero LJ, de la Pompa JL (2016) Sequential Notch activation regulates ventricular chamber development. Nat Cell Biol 18(1):7–20. https://doi.org/10.1038/ncb3280
-
(2016)
Nat Cell Biol
, vol.18
, Issue.1
, pp. 7-20
-
-
D'amato, G.1
Luxan, G.2
Del Monte-Nieto, G.3
Martinez-Poveda, B.4
Torroja, C.5
Walter, W.6
Bochter, M.S.7
Benedito, R.8
Cole, S.9
Martinez, F.10
Hadjantonakis, A.K.11
Uemura, A.12
Jimenez-Borreguero, L.J.13
de la Pompa, J.L.14
-
18
-
-
0037066706
-
Absence of post-translational aspartyl beta-hydroxylation of epidermal growth factor domains in mice leads to developmental defects and an increased incidence of intestinal neoplasia
-
Dinchuk JE, Focht RJ, Kelley JA, Henderson NL, Zolotarjova NI, Wynn R, Neff NT, Link J, Huber RM, Burn TC, Rupar MJ, Cunningham MR, Selling BH, Ma J, Stern AA, Hollis GF, Stein RB, Friedman PA (2002) Absence of post-translational aspartyl beta-hydroxylation of epidermal growth factor domains in mice leads to developmental defects and an increased incidence of intestinal neoplasia. J Biol Chem 277(15):12970–12977. https://doi.org/10.1074/jbc. M110389200
-
(2002)
J Biol Chem
, vol.277
, Issue.15
, pp. 12970-12977
-
-
Dinchuk, J.E.1
Focht, R.J.2
Kelley, J.A.3
Henderson, N.L.4
Zolotarjova, N.I.5
Wynn, R.6
Neff, N.T.7
Link, J.8
Huber, R.M.9
Burn, T.C.10
Rupar, M.J.11
Cunningham, M.R.12
Selling, B.H.13
Ma, J.14
Stern, A.A.15
Hollis, G.F.16
Stein, R.B.17
Friedman, P.A.18
-
19
-
-
85008429830
-
Bioinformatics insight into glycosyltransferase gene expression in gastric cancer: POFUT1 is a potential biomarker
-
Dong S, Wang Z, Huang B, Zhang J, Ge Y, Fan Q, Wang Z (2017) Bioinformatics insight into glycosyltransferase gene expression in gastric cancer: POFUT1 is a potential biomarker. Biochem Biophys Res Commun 483(1):171–177. https://doi.org/10.1016/j. bbrc.2016.12.172
-
(2017)
Biochem Biophys Res Commun
, vol.483
, Issue.1
, pp. 171-177
-
-
Dong, S.1
Wang, Z.2
Huang, B.3
Zhang, J.4
Ge, Y.5
Fan, Q.6
Wang, Z.7
-
20
-
-
0032560814
-
Lunatic fringe is an essential mediator of somite segmentation and patterning
-
Evrard YA, Lun Y, Aulehla A, Gan L, Johnson RL (1998) Lunatic fringe is an essential mediator of somite segmentation and patterning. Nature 394(6691):377–381. https://doi.org/10.1038/28632
-
(1998)
Nature
, vol.394
, Issue.6691
, pp. 377-381
-
-
Evrard, Y.A.1
Lun, Y.2
Aulehla, A.3
Gan, L.4
Johnson, R.L.5
-
21
-
-
0025277746
-
Molecular interactions between the protein products of the neurogenic loci Notch and Delta, two EGF-homologous genes in Drosophila
-
Fehon RG, Kooh PJ, Rebay I, Regan CL, Xu T, Muskavitch MA, Artavanis-Tsakonas S (1990) Molecular interactions between the protein products of the neurogenic loci Notch and Delta, two EGF-homologous genes in Drosophila. Cell 61(3):523–534
-
(1990)
Cell
, vol.61
, Issue.3
, pp. 523-534
-
-
Fehon, R.G.1
Kooh, P.J.2
Rebay, I.3
Regan, C.L.4
Xu, T.5
Muskavitch, M.A.6
Artavanis-Tsakonas, S.7
-
22
-
-
79955561765
-
Regulation of mammalian Notch signaling and embryonic development by the protein O-glucosyltransferase Rumi
-
Fernandez-Valdivia R, Takeuchi H, Samarghandi A, Lopez M, Leonardi J, Haltiwanger RS, Jafar-Nejad H (2011) Regulation of mammalian Notch signaling and embryonic development by the protein O-glucosyltransferase Rumi. Development 138(10):1925–1934. https://doi. org/10.1242/dev.060020
-
(2011)
Development
, vol.138
, Issue.10
, pp. 1925-1934
-
-
Fernandez-Valdivia, R.1
Takeuchi, H.2
Samarghandi, A.3
Lopez, M.4
Leonardi, J.5
Haltiwanger, R.S.6
Jafar-Nejad, H.7
-
23
-
-
40349089637
-
The O-fucose glycan in the ligand-binding domain of Notch1 regulates embryogenesis and T cell development
-
Ge C, Stanley P (2008) The O-fucose glycan in the ligand-binding domain of Notch1 regulates embryogenesis and T cell development. Proc Natl Acad Sci U S A 105(5):1539–1544. https://doi.org/10.1073/pnas.0702846105
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, Issue.5
, pp. 1539-1544
-
-
Ge, C.1
Stanley, P.2
-
24
-
-
84912141672
-
The protein O-glucosyltransferase Rumi modifies eyes shut to promote rhabdomere separation in Drosophila
-
Haltom AR, Lee TV, Harvey BM, Leonardi J, Chen YJ, Hong Y, Haltiwanger RS, Jafar-Nejad H (2014) The protein O-glucosyltransferase Rumi modifies eyes shut to promote rhabdomere separation in Drosophila. PLoS Genet 10(11):e1004795. https://doi. org/10.1371/journal.pgen.1004795
-
(2014)
Plos Genet
, vol.10
, Issue.11
-
-
Haltom, A.R.1
Lee, T.V.2
Harvey, B.M.3
Leonardi, J.4
Chen, Y.J.5
Hong, Y.6
Haltiwanger, R.S.7
Jafar-Nejad, H.8
-
25
-
-
9944226224
-
Structural and functional properties of the human notch-1 ligand binding region
-
Hambleton S, Valeyev NV, Muranyi A, Knott V, Werner JM, McMichael AJ, Handford PA, Downing AK (2004) Structural and functional properties of the human notch-1 ligand binding region. Structure 12(12):2173– 2183. https://doi.org/10.1016/j.str.2004.09.012
-
(2004)
Structure
, vol.12
, Issue.12
, pp. 2173-2183
-
-
Hambleton, S.1
Valeyev, N.V.2
Muranyi, A.3
Knott, V.4
Werner, J.M.5
McMichael, A.J.6
Handford, P.A.7
Downing, A.K.8
-
26
-
-
0027205366
-
O-linked fucose and other post-translational modifications unique to EGF modules
-
Harris RJ, Spellman MW (1993) O-linked fucose and other post-translational modifications unique to EGF modules. Glycobiology 3(3):219–224
-
(1993)
Glycobiology
, vol.3
, Issue.3
, pp. 219-224
-
-
Harris, R.J.1
Spellman, M.W.2
-
27
-
-
84979781370
-
Mapping sites of O-glycosylation and fringe elongation on Drosophila Notch
-
Harvey BM, Rana NA, Moss H, Leonardi J, Jafar-Nejad H, Haltiwanger RS (2016) Mapping sites of O-glycosylation and fringe elongation on Drosophila Notch. J Biol Chem 291(31):16348–16360. https://doi.org/10.1074/jbc.M116.732537
-
(2016)
J Biol Chem
, vol.291
, Issue.31
, pp. 16348-16360
-
-
Harvey, B.M.1
Rana, N.A.2
Moss, H.3
Leonardi, J.4
Jafar-Nejad, H.5
Haltiwanger, R.S.6
-
28
-
-
0024270443
-
A new trisaccharide sugar chain linked to a serine residue in bovine blood coagulation factors VII and IX
-
Hase S, Kawabata S, Nishimura H, Takeya H, Sueyoshi T, Miyata T, Iwanaga S, Takao T, Shimonishi Y, Ikenaka T (1988) A new trisaccharide sugar chain linked to a serine residue in bovine blood coagulation factors VII and IX. J Biochem 104(6):867–868
-
(1988)
J Biochem
, vol.104
, Issue.6
, pp. 867-868
-
-
Hase, S.1
Kawabata, S.2
Nishimura, H.3
Takeya, H.4
Sueyoshi, T.5
Miyata, T.6
Iwanaga, S.7
Takao, T.8
Shimonishi, Y.9
Ikenaka, T.10
-
29
-
-
0025192470
-
The structure of (Xylose)2glucose-O-serine 53 found in the first epidermal growth factor-like domain of bovine blood clotting factor IX
-
Hase S, Nishimura H, Kawabata S, Iwanaga S, Ikenaka T (1990) The structure of (xylose)2glucose-O-serine 53 found in the first epidermal growth factor-like domain of bovine blood clotting factor IX. J Biol Chem 265(4):1858–1861
-
(1990)
J Biol Chem
, vol.265
, Issue.4
, pp. 1858-1861
-
-
Hase, S.1
Nishimura, H.2
Kawabata, S.3
Iwanaga, S.4
Ikenaka, T.5
-
30
-
-
84957922453
-
Synthetic human NOTCH1 EGF modules unraveled molecular mechanisms for the structural and functional roles of calcium ions and O-Glycans in the ligand-binding region
-
Hayakawa S, Koide R, Hinou H, Nishimura S (2016) Synthetic human NOTCH1 EGF modules unraveled molecular mechanisms for the structural and functional roles of calcium ions and O-Glycans in the ligand-binding region. Biochemistry 55(5):776–787. https://doi.org/10.1021/acs.biochem.5b01284
-
(2016)
Biochemistry
, vol.55
, Issue.5
, pp. 776-787
-
-
Hayakawa, S.1
Koide, R.2
Hinou, H.3
Nishimura, S.4
-
31
-
-
0034253589
-
Fringe differentially modulates Jagged1 and Delta1 signalling through Notch1 and Notch2
-
Hicks C, Johnston SH, diSibio G, Collazo A, Vogt TF, Weinmaster G (2000) Fringe differentially modulates Jagged1 and Delta1 signalling through Notch1 and Notch2. Nat Cell Biol 2(8):515–520. https://doi. org/10.1038/35019553
-
(2000)
Nat Cell Biol
, vol.2
, Issue.8
, pp. 515-520
-
-
Hicks, C.1
Johnston, S.H.2
Disibio, G.3
Collazo, A.4
Vogt, T.F.5
Weinmaster, G.6
-
32
-
-
77958492721
-
Chemical synthesis, folding, and structural insights into O-fucosylated epidermal growth factor-like repeat 12 of mouse Notch-1 receptor
-
Hiruma-Shimizu K, Hosoguchi K, Liu Y, Fujitani N, Ohta T, Hinou H, Matsushita T, Shimizu H, Feizi T, Nishimura S (2010) Chemical synthesis, folding, and structural insights into O-fucosylated epidermal growth factor-like repeat 12 of mouse Notch-1 receptor. J Am Chem Soc 132(42):14857–14865. https://doi.org/10.1021/ja105216u
-
(2010)
J am Chem Soc
, vol.132
, Issue.42
, pp. 14857-14865
-
-
Hiruma-Shimizu, K.1
Hosoguchi, K.2
Liu, Y.3
Fujitani, N.4
Ohta, T.5
Hinou, H.6
Matsushita, T.7
Shimizu, H.8
Feizi, T.9
Nishimura, S.10
-
33
-
-
84879870498
-
Notch signaling at a glance
-
Pt 10
-
Hori K, Sen A, Artavanis-Tsakonas S (2013) Notch signaling at a glance. J Cell Sci 126(Pt 10):2135–2140. https://doi.org/10.1242/jcs.127308
-
(2013)
J Cell Sci
, vol.126
, pp. 2135-2140
-
-
Hori, K.1
Sen, A.2
Artavanis-Tsakonas, S.3
-
34
-
-
84855290478
-
Galactose differentially modulates lunatic and manic fringe effects on Delta1-induced NOTCH signaling
-
Hou X, Tashima Y, Stanley P (2012) Galactose differentially modulates lunatic and manic fringe effects on Delta1-induced NOTCH signaling. J Biol Chem 287(1):474–483. https://doi.org/10.1074/jbc. M111.317578
-
(2012)
J Biol Chem
, vol.287
, Issue.1
, pp. 474-483
-
-
Hou, X.1
Tashima, Y.2
Stanley, P.3
-
35
-
-
0027945519
-
Fringe, a boundary-specific signaling molecule, mediates interactions between dorsal and ventral cells during Drosophila wing development
-
Irvine KD, Wieschaus E (1994) Fringe, a boundary-specific signaling molecule, mediates interactions between dorsal and ventral cells during Drosophila wing development. Cell 79(4):595–606
-
(1994)
Cell
, vol.79
, Issue.4
, pp. 595-606
-
-
Irvine, K.D.1
Wieschaus, E.2
-
36
-
-
33749526524
-
Structural insights into the Notch-modifying glycosyltransferase fringe
-
Jinek M, Chen YW, Clausen H, Cohen SM, Conti E (2006) Structural insights into the Notch-modifying glycosyltransferase fringe. Nat Struct Mol Biol 13(10):945– 946. https://doi.org/10.1038/nsmb1144
-
(2006)
Nat Struct Mol Biol
, vol.13
, Issue.10
, pp. 945-946
-
-
Jinek, M.1
Chen, Y.W.2
Clausen, H.3
Cohen, S.M.4
Conti, E.5
-
37
-
-
0030744231
-
A family of mammalian fringe genes implicated in boundary determination and the Notch pathway
-
Johnston SH, Rauskolb C, Wilson R, Prabhakaran B, Irvine KD, Vogt TF (1997) A family of mammalian fringe genes implicated in boundary determination and the Notch pathway. Development 124(11):2245–2254
-
(1997)
Development
, vol.124
, Issue.11
, pp. 2245-2254
-
-
Johnston, S.H.1
Rauskolb, C.2
Wilson, R.3
Prabhakaran, B.4
Irvine, K.D.5
Vogt, T.F.6
-
38
-
-
16044362074
-
Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia
-
Joutel A, Corpechot C, Ducros A, Vahedi K, Chabriat H, Mouton P, Alamowitch S, Domenga V, Cecillion M, Marechal E, Maciazek J, Vayssiere C, Cruaud C, Cabanis EA, Ruchoux MM, Weissenbach J, Bach JF, Bousser MG, Tournier-Lasserve E (1996) Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia. Nature 383(6602):707– 710. https://doi.org/10.1038/383707a0
-
(1996)
Nature
, vol.383
, Issue.6602
, pp. 707-710
-
-
Joutel, A.1
Corpechot, C.2
Ducros, A.3
Vahedi, K.4
Chabriat, H.5
Mouton, P.6
Alamowitch, S.7
Domenga, V.8
Cecillion, M.9
Marechal, E.10
Maciazek, J.11
Vayssiere, C.12
Cruaud, C.13
Cabanis, E.A.14
Ruchoux, M.M.15
Weissenbach, J.16
Bach, J.F.17
Bousser, M.G.18
Tournier-Lasserve, E.19
-
39
-
-
85009802398
-
Deciphering the fringe-mediated Notch code: Identification of activating and inhibiting sites allowing discrimination between ligands
-
Kakuda S, Haltiwanger RS (2017) Deciphering the fringe-mediated Notch code: identification of activating and inhibiting sites allowing discrimination between ligands. Dev Cell 40(2):193–201. https://doi. org/10.1016/j.devcel.2016.12.013
-
(2017)
Dev Cell
, vol.40
, Issue.2
, pp. 193-201
-
-
Kakuda, S.1
Haltiwanger, R.S.2
-
40
-
-
84855991075
-
NOTCH2 mutations in Alagille syndrome
-
Kamath BM, Bauer RC, Loomes KM, Chao G, Gerfen J, Hutchinson A, Hardikar W, Hirschfield G, Jara P, Krantz ID, Lapunzina P, Leonard L, Ling S, Ng VL, Hoang PL, Piccoli DA, Spinner NB (2012) NOTCH2 mutations in Alagille syndrome. J Med Genet 49(2):138–144. https://doi.org/10.1136/jmedgenet-2011-100544
-
(2012)
J Med Genet
, vol.49
, Issue.2
, pp. 138-144
-
-
Kamath, B.M.1
Bauer, R.C.2
Loomes, K.M.3
Chao, G.4
Gerfen, J.5
Hutchinson, A.6
Hardikar, W.7
Hirschfield, G.8
Jara, P.9
Krantz, I.D.10
Lapunzina, P.11
Leonard, L.12
Ling, S.13
Ng, V.L.14
Hoang, P.L.15
Piccoli, D.A.16
Spinner, N.B.17
-
41
-
-
0025083117
-
Carbohydrate composition and presence of a fucose-protein linkage in recombinant human pro-urokinase
-
Kentzer EJ, Buko A, Menon G, Sarin VK (1990) Carbohydrate composition and presence of a fucose-protein linkage in recombinant human pro-urokinase. Biochem Biophys Res Commun 171(1):401–406
-
(1990)
Biochem Biophys Res Commun
, vol.171
, Issue.1
, pp. 401-406
-
-
Kentzer, E.J.1
Buko, A.2
Menon, G.3
Sarin, V.K.4
-
42
-
-
84935018174
-
Notch ligand delta-like1: X-ray crystal structure and binding affinity
-
Kershaw NJ, Church NL, Griffin MD, Luo CS, Adams TE, Burgess AW (2015) Notch ligand delta-like1: X-ray crystal structure and binding affinity. Biochem J 468(1):159–166. https://doi.org/10.1042/BJ20150010
-
(2015)
Biochem J
, vol.468
, Issue.1
, pp. 159-166
-
-
Kershaw, N.J.1
Church, N.L.2
Griffin, M.D.3
Luo, C.S.4
Adams, T.E.5
Burgess, A.W.6
-
43
-
-
64249172203
-
The canonical Notch signaling pathway: Unfolding the activation mechanism
-
Kopan R, Ilagan MX (2009) The canonical Notch signaling pathway: unfolding the activation mechanism. Cell 137(2):216–233. https://doi.org/10.1016/j. cell.2009.03.045
-
(2009)
Cell
, vol.137
, Issue.2
, pp. 216-233
-
-
Kopan, R.1
Ilagan, M.X.2
-
44
-
-
0030959555
-
Dynamic glycosylation of nuclear and cytosolic proteins Cloning and characterization of a unique O-GlcNAc transferase with multiple tetratricopeptide repeats
-
Kreppel LK, Blomberg MA, Hart GW (1997) Dynamic glycosylation of nuclear and cytosolic proteins Cloning and characterization of a unique O-GlcNAc transferase with multiple tetratricopeptide repeats. J Biol Chem 272(14):9308–9315
-
(1997)
J Biol Chem
, vol.272
, Issue.14
, pp. 9308-9315
-
-
Kreppel, L.K.1
Blomberg, M.A.2
Hart, G.W.3
-
45
-
-
38449088811
-
Focused micro-array analysis of glyco-gene expression in human glio-blastomas
-
Kroes RA, Dawson G, Moskal JR (2007) Focused micro-array analysis of glyco-gene expression in human glio-blastomas. J Neurochem 103(Suppl 1):14–24. https://doi.org/10.1111/j.1471-4159.2007.04780.x
-
(2007)
J Neurochem
, vol.103
, pp. 14-24
-
-
Kroes, R.A.1
Dawson, G.2
Moskal, J.R.3
-
46
-
-
0029744297
-
Overexpression of human aspartyl(Asparaginyl)beta-hydroxylase in hepatocellular carcinoma and cholangiocarci-noma
-
Lavaissiere L, Jia S, Nishiyama M, de la Monte S, Stern AM, Wands JR, Friedman PA (1996) Overexpression of human aspartyl(asparaginyl)beta-hydroxylase in hepatocellular carcinoma and cholangiocarci-noma. J Clin Invest 98(6):1313–1323. https://doi. org/10.1172/JCI118918
-
(1996)
J Clin Invest
, vol.98
, Issue.6
, pp. 1313-1323
-
-
Lavaissiere, L.1
Jia, S.2
Nishiyama, M.3
de la Monte, S.4
Stern, A.M.5
Wands, J.R.6
Friedman, P.A.7
-
47
-
-
84922373656
-
Fringe proteins modulate Notch-ligand cis and trans interactions to specify signaling states
-
LeBon L, Lee TV, Sprinzak D, Jafar-Nejad H, Elowitz MB (2014) Fringe proteins modulate Notch-ligand cis and trans interactions to specify signaling states. elife 3:e02950. https://doi.org/10.7554/eLife.02950
-
(2014)
Elife
, vol.3
-
-
Lebon, L.1
Lee, T.V.2
Sprinzak, D.3
Jafar-Nejad, H.4
Elowitz, M.B.5
-
48
-
-
84879660816
-
Negative regulation of notch signaling by xylose
-
Lee TV, Sethi MK, Leonardi J, Rana NA, Buettner FF, Haltiwanger RS, Bakker H, Jafar-Nejad H (2013) Negative regulation of notch signaling by xylose. PLoS Genet 9(6):e1003547. https://doi.org/10.1371/journal.pgen.1003547
-
(2013)
Plos Genet
, vol.9
, Issue.6
-
-
Lee, T.V.1
Sethi, M.K.2
Leonardi, J.3
Rana, N.A.4
Buettner, F.F.5
Haltiwanger, R.S.6
Bakker, H.7
Jafar-Nejad, H.8
-
49
-
-
0346505185
-
An O-fucose site in the ligand binding domain inhibits Notch activation
-
Lei L, Xu A, Panin VM, Irvine KD (2003) An O-fucose site in the ligand binding domain inhibits Notch activation. Development 130(26):6411–6421. https://doi. org/10.1242/dev.00883
-
(2003)
Development
, vol.130
, Issue.26
, pp. 6411-6421
-
-
Lei, L.1
Xu, A.2
Panin, V.M.3
Irvine, K.D.4
-
50
-
-
79960763491
-
Multiple O-glucosylation sites on Notch function as a buffer against temperature-depen-dent loss of signaling
-
Leonardi J, Fernandez-Valdivia R, Li YD, Simcox AA, Jafar-Nejad H (2011) Multiple O-glucosylation sites on Notch function as a buffer against temperature-depen-dent loss of signaling. Development 138(16):3569– 3578. https://doi.org/10.1242/dev.068361
-
(2011)
Development
, vol.138
, Issue.16
, pp. 3569-3578
-
-
Leonardi, J.1
Fernandez-Valdivia, R.2
Li, Y.D.3
Simcox, A.A.4
Jafar-Nejad, H.5
-
51
-
-
84878884428
-
Mutations in POFUT1, encoding protein O-fucosyltransferase 1, cause generalized Dowling-Degos disease
-
Li M, Cheng R, Liang J, Yan H, Zhang H, Yang L, Li C, Jiao Q, Lu Z, He J, Ji J, Shen Z, Li C, Hao F, Yu H, Yao Z (2013) Mutations in POFUT1, encoding protein O-fucosyltransferase 1, cause generalized Dowling-Degos disease. Am J Hum Genet 92(6):895–903. https://doi.org/10.1016/j.ajhg.2013.04.022
-
(2013)
Am J Hum Genet
, vol.92
, Issue.6
, pp. 895-903
-
-
Li, M.1
Cheng, R.2
Liang, J.3
Yan, H.4
Zhang, H.5
Yang, L.6
Li, C.7
Jiao, Q.8
Lu, Z.9
He, J.10
Ji, J.11
Shen, Z.12
Li, C.13
Hao, F.14
Yu, H.15
Yao, Z.16
-
52
-
-
84951188094
-
Pathogenicity of POFUT1 mutations in two Chinese families with Dowling-Degos disease
-
Li CR, Brooks YS, Jia WX, Wang DG, Xiao XM, Li Q, Li M, Mao QX, Wang B (2016) Pathogenicity of POFUT1 mutations in two Chinese families with Dowling-Degos disease. J Eur Acad Dermatol Venereol 30(10):e79–e81. https://doi.org/10.1111/jdv.13323
-
(2016)
J Eur Acad Dermatol Venereol
, vol.30
, Issue.10
, pp. e79-e81
-
-
Li, C.R.1
Brooks, Y.S.2
Jia, W.X.3
Wang, D.G.4
Xiao, X.M.5
Li, Q.6
Li, M.7
Mao, Q.X.8
Wang, B.9
-
53
-
-
85021122264
-
Recognition of EGF-like domains by the notch-modifying O-fucosyltransferase POFUT1
-
Li Z, Han K, Pak JE, Satkunarajah M, Zhou D, Rini JM (2017) Recognition of EGF-like domains by the notch-modifying O-fucosyltransferase POFUT1. Nat Chem Biol 13(7):757–763. https://doi.org/10.1038/nchembio.2381
-
(2017)
Nat Chem Biol
, vol.13
, Issue.7
, pp. 757-763
-
-
Li, Z.1
Han, K.2
Pak, J.E.3
Satkunarajah, M.4
Zhou, D.5
Rini, J.M.6
-
54
-
-
0035968317
-
Molecular analysis of the epidermal growth factor-like short consensus repeat domain-mediated protein-protein interactions: Dissection of the CD97-CD55 complex
-
Lin HH, Stacey M, Saxby C, Knott V, Chaudhry Y, Evans D, Gordon S, McKnight AJ, Handford P, Lea S (2001) Molecular analysis of the epidermal growth factor-like short consensus repeat domain-mediated protein-protein interactions: dissection of the CD97-CD55 complex. J Biol Chem 276(26):24160–24169. https://doi. org/10.1074/jbc.M101770200
-
(2001)
J Biol Chem
, vol.276
, Issue.26
, pp. 24160-24169
-
-
Lin, H.H.1
Stacey, M.2
Saxby, C.3
Knott, V.4
Chaudhry, Y.5
Evans, D.6
Gordon, S.7
McKnight, A.J.8
Handford, P.9
Lea, S.10
-
55
-
-
80053157756
-
Structural insights into the mechanism of protein O-fucosylation
-
Lira-Navarrete E, Valero-Gonzalez J, Villanueva R, Martinez-Julvez M, Tejero T, Merino P, Panjikar S, Hurtado-Guerrero R (2011) Structural insights into the mechanism of protein O-fucosylation. PLoS One 6(9):e25365. https://doi.org/10.1371/journal. pone.0025365
-
(2011)
Plos One
, vol.6
, Issue.9
-
-
Lira-Navarrete, E.1
Valero-Gonzalez, J.2
Villanueva, R.3
Martinez-Julvez, M.4
Tejero, T.5
Merino, P.6
Panjikar, S.7
Hurtado-Guerrero, R.8
-
56
-
-
84879532571
-
The extracellular domain of Notch2 increases its cell-surface abundance and ligand responsiveness during kidney development
-
Liu Z, Chen S, Boyle S, Zhu Y, Zhang A, Piwnica-Worms DR, Ilagan MX, Kopan R (2013) The extracellular domain of Notch2 increases its cell-surface abundance and ligand responsiveness during kidney development. Dev Cell 25(6):585–598. https://doi.org/10.1016/j. devcel.2013.05.022
-
(2013)
Dev Cell
, vol.25
, Issue.6
, pp. 585-598
-
-
Liu, Z.1
Chen, S.2
Boyle, S.3
Zhu, Y.4
Zhang, A.5
Piwnica-Worms, D.R.6
Ilagan, M.X.7
Kopan, R.8
-
57
-
-
84875078280
-
Integrated analysis of genome-wide copy number alterations and gene expression in microsatellite stable, CpG island methylator phenotype-negative colon cancer
-
Loo LW, Tiirikainen M, Cheng I, Lum-Jones A, Seifried A, Church JM, Gryfe R, Weisenberger DJ, Lindor NM, Gallinger S, Haile RW, Duggan DJ, Thibodeau SN, Casey G, Le Marchand L (2013) Integrated analysis of genome-wide copy number alterations and gene expression in microsatellite stable, CpG island methylator phenotype-negative colon cancer. Genes Chromosom Cancer 52(5):450–466. https://doi. org/10.1002/gcc.22043
-
(2013)
Genes Chromosom Cancer
, vol.52
, Issue.5
, pp. 450-466
-
-
Loo, L.W.1
Tiirikainen, M.2
Cheng, I.3
Lum-Jones, A.4
Seifried, A.5
Church, J.M.6
Gryfe, R.7
Weisenberger, D.J.8
Lindor, N.M.9
Gallinger, S.10
Haile, R.W.11
Duggan, D.J.12
Thibodeau, S.N.13
Casey, G.14
Le Marchand, L.15
-
58
-
-
0031567823
-
Targeted mutation in beta1,4-galactosyltransferase leads to pituitary insufficiency and neonatal lethality
-
Lu Q, Hasty P, Shur BD (1997) Targeted mutation in beta1,4-galactosyltransferase leads to pituitary insufficiency and neonatal lethality. Dev Biol 181(2):257– 267. https://doi.org/10.1006/dbio.1996.8444
-
(1997)
Dev Biol
, vol.181
, Issue.2
, pp. 257-267
-
-
Lu, Q.1
Hasty, P.2
Shur, B.D.3
-
59
-
-
84923309385
-
Structural biology. Structural basis for Notch1 engagement of Delta-like 4
-
Luca VC, Jude KM, Pierce NW, Nachury MV, Fischer S, Garcia KC (2015) Structural biology. Structural basis for Notch1 engagement of Delta-like 4. Science 347(6224):847–853. https://doi.org/10.1126/science.1261093
-
(2015)
Science
, vol.347
, Issue.6224
, pp. 847-853
-
-
Luca, V.C.1
Jude, K.M.2
Pierce, N.W.3
Nachury, M.V.4
Fischer, S.5
Garcia, K.C.6
-
60
-
-
85014437670
-
Notch-Jagged complex structure implicates a catch bond in tuning ligand sensitivity
-
Luca VC, Kim BC, Ge C, Kakuda S, Wu D, Roein-Peikar M, Haltiwanger RS, Zhu C, Ha T, Garcia KC (2017) Notch-Jagged complex structure implicates a catch bond in tuning ligand sensitivity. Science 355(6331):1320–1324. https://doi.org/10.1126/sci-ence.aaf9739
-
(2017)
Science
, vol.355
, Issue.6331
, pp. 1320-1324
-
-
Luca, V.C.1
Kim, B.C.2
Ge, C.3
Kakuda, S.4
Wu, D.5
Roein-Peikar, M.6
Haltiwanger, R.S.7
Zhu, C.8
Ha, T.9
Garcia, K.C.10
-
61
-
-
15744372996
-
O-fucosylation of notch occurs in the endoplasmic reticulum
-
Luo Y, Haltiwanger RS (2005) O-fucosylation of notch occurs in the endoplasmic reticulum. J Biol Chem 280(12):11289–11294. https://doi.org/10.1074/jbc. M414574200
-
(2005)
J Biol Chem
, vol.280
, Issue.12
, pp. 11289-11294
-
-
Luo, Y.1
Haltiwanger, R.S.2
-
62
-
-
84962091296
-
Overexpression of protein O-fucosyltransferase 1 accelerates hepatocellular carcinoma progression via the Notch signaling pathway
-
Ma L, Dong P, Liu L, Gao Q, Duan M, Zhang S, Chen S, Xue R, Wang X (2016) Overexpression of protein O-fucosyltransferase 1 accelerates hepatocellular carcinoma progression via the Notch signaling pathway. Biochem Biophys Res Commun 473(2):503–510. https://doi.org/10.1016/j.bbrc.2016.03.062
-
(2016)
Biochem Biophys Res Commun
, vol.473
, Issue.2
, pp. 503-510
-
-
Ma, L.1
Dong, P.2
Liu, L.3
Gao, Q.4
Duan, M.5
Zhang, S.6
Chen, S.7
Xue, R.8
Wang, X.9
-
63
-
-
84975824446
-
Dual roles of O-glucose Glycans redundant with monosaccharide O-Fucose on Notch in Notch trafficking
-
Matsumoto K, Ayukawa T, Ishio A, Sasamura T, Yamakawa T, Matsuno K (2016) Dual roles of O-glucose Glycans redundant with monosaccharide O-Fucose on Notch in Notch trafficking. J Biol Chem 291(26):13743–13752. https://doi.org/10.1074/jbc.M115.710483
-
(2016)
J Biol Chem
, vol.291
, Issue.26
, pp. 13743-13752
-
-
Matsumoto, K.1
Ayukawa, T.2
Ishio, A.3
Sasamura, T.4
Yamakawa, T.5
Matsuno, K.6
-
64
-
-
58149091978
-
O-linked N-acetylglucosamine is present on the extracellular domain of notch receptors
-
Matsuura A, Ito M, Sakaidani Y, Kondo T, Murakami K, Furukawa K, Nadano D, Matsuda T, Okajima T (2008) O-linked N-acetylglucosamine is present on the extracellular domain of notch receptors. J Biol Chem 283(51):35486–35495. https://doi.org/10.1074/jbc.M806202200
-
(2008)
J Biol Chem
, vol.283
, Issue.51
, pp. 35486-35495
-
-
Matsuura, A.1
Ito, M.2
Sakaidani, Y.3
Kondo, T.4
Murakami, K.5
Furukawa, K.6
Nadano, D.7
Matsuda, T.8
Okajima, T.9
-
65
-
-
33745232796
-
NOTCH2 mutations cause Alagille syndrome, a heterogeneous disorder of the Notch signaling pathway
-
McDaniell R, Warthen DM, Sanchez-Lara PA, Pai A, Krantz ID, Piccoli DA, Spinner NB (2006) NOTCH2 mutations cause Alagille syndrome, a heterogeneous disorder of the Notch signaling pathway. Am J Hum Genet 79(1):169–173. https://doi.org/10.1086/505332
-
(2006)
Am J Hum Genet
, vol.79
, Issue.1
, pp. 169-173
-
-
McDaniell, R.1
Warthen, D.M.2
Sanchez-Lara, P.A.3
Pai, A.4
Krantz, I.D.5
Piccoli, D.A.6
Spinner, N.B.7
-
66
-
-
85028337622
-
Structure of human POFUT1, its requirement in ligand-independent oncogenic Notch signaling, and functional effects of Dowling-Degos mutations
-
McMillan BJ, Zimmerman B, Egan ED, Lofgren M, Xu X, Hesser A, Blacklow SC (2017) Structure of human POFUT1, its requirement in ligand-independent oncogenic Notch signaling, and functional effects of Dowling-Degos mutations. Glycobiology:1–10. https://doi.org/10.1093/glycob/cwx020
-
(2017)
Glycobiology
, pp. 1-10
-
-
McMillan, B.J.1
Zimmerman, B.2
Egan, E.D.3
Lofgren, M.4
Xu, X.5
Hesser, A.6
Blacklow, S.C.7
-
67
-
-
84941026103
-
Heterozygous loss-of-function mutations in DLL4 cause Adams-Oliver syndrome
-
Meester JA, Southgate L, Stittrich AB, Venselaar H, Beekmans SJ, den Hollander N, Bijlsma EK, Helderman-van den Enden A, Verheij JB, Glusman G, Roach JC, Lehman A, Patel MS, de Vries BB, Ruivenkamp C, Itin P, Prescott K, Clarke S, Trembath R, Zenker M, Sukalo M, Van Laer L, Loeys B, Wuyts W (2015) Heterozygous loss-of-function mutations in DLL4 cause Adams-Oliver syndrome. Am J Hum Genet 97(3):475–482. https://doi.org/10.1016/j. ajhg.2015.07.015
-
(2015)
Am J Hum Genet
, vol.97
, Issue.3
, pp. 475-482
-
-
Meester, J.A.1
Southgate, L.2
Stittrich, A.B.3
Venselaar, H.4
Beekmans, S.J.5
Den Hollander, N.6
Bijlsma, E.K.7
Helderman-Van Den Enden, A.8
Verheij, J.B.9
Glusman, G.10
Roach, J.C.11
Lehman, A.12
Patel, M.S.13
de Vries, B.B.14
Ruivenkamp, C.15
Itin, P.16
Prescott, K.17
Clarke, S.18
Trembath, R.19
Zenker, M.20
Sukalo, M.21
van Laer, L.22
Loeys, B.23
Wuyts, W.24
more..
-
68
-
-
0001395691
-
Fringe is a glycosyltransferase that modifies Notch
-
Moloney DJ, Panin VM, Johnston SH, Chen J, Shao L, Wilson R, Wang Y, Stanley P, Irvine KD, Haltiwanger RS, Vogt TF (2000a) Fringe is a glycosyltransferase that modifies Notch. Nature 406(6794):369–375. https://doi.org/10.1038/35019000
-
(2000)
Nature
, vol.406
, Issue.6794
, pp. 369-375
-
-
Moloney, D.J.1
Panin, V.M.2
Johnston, S.H.3
Chen, J.4
Shao, L.5
Wilson, R.6
Wang, Y.7
Stanley, P.8
Irvine, K.D.9
Haltiwanger, R.S.10
Vogt, T.F.11
-
69
-
-
0034737738
-
Mammalian Notch1 is modified with two unusual forms of O-linked glycosylation found on epidermal growth factor-like modules
-
Moloney DJ, Shair LH, Lu FM, Xia J, Locke R, Matta KL, Haltiwanger RS (2000b) Mammalian Notch1 is modified with two unusual forms of O-linked glycosylation found on epidermal growth factor-like modules. J Biol Chem 275(13):9604–9611
-
(2000)
J Biol Chem
, vol.275
, Issue.13
, pp. 9604-9611
-
-
Moloney, D.J.1
Shair, L.H.2
Lu, F.M.3
Xia, J.4
Locke, R.5
Matta, K.L.6
Haltiwanger, R.S.7
-
70
-
-
67649588261
-
Manic fringe is not required for embryonic development, and fringe family members do not exhibit redundant functions in the axial skeleton, limb, or hindbrain
-
Moran JL, Shifley ET, Levorse JM, Mani S, Ostmann K, Perez-Balaguer A, Walker DM, Vogt TF, Cole SE (2009) Manic fringe is not required for embryonic development, and fringe family members do not exhibit redundant functions in the axial skeleton, limb, or hindbrain. Dev Dyn 238(7):1803–1812. https://doi. org/10.1002/dvdy.21982
-
(2009)
Dev Dyn
, vol.238
, Issue.7
, pp. 1803-1812
-
-
Moran, J.L.1
Shifley, E.T.2
Levorse, J.M.3
Mani, S.4
Ostmann, K.5
Perez-Balaguer, A.6
Walker, D.M.7
Vogt, T.F.8
Cole, S.E.9
-
71
-
-
84877343228
-
The EGF repeat-specific O-GlcNAc-transferase Eogt interacts with notch signaling and pyrimidine metabolism pathways in Drosophila
-
Muller R, Jenny A, Stanley P (2013) The EGF repeat-specific O-GlcNAc-transferase Eogt interacts with notch signaling and pyrimidine metabolism pathways in Drosophila. PLoS One 8(5):e62835. https://doi. org/10.1371/journal.pone.0062835
-
(2013)
Plos One
, vol.8
, Issue.5
-
-
Muller, R.1
Jenny, A.2
Stanley, P.3
-
72
-
-
84895760653
-
O-fucosylation of the notch ligand mDLL1 by POFUT1 is dispensable for ligand function
-
Muller J, Rana NA, Serth K, Kakuda S, Haltiwanger RS, Gossler A (2014) O-fucosylation of the notch ligand mDLL1 by POFUT1 is dispensable for ligand function. PLoS One 9(2):e88571. https://doi.org/10.1371/journal.pone.0088571
-
(2014)
Plos One
, vol.9
, Issue.2
-
-
Muller, J.1
Rana, N.A.2
Serth, K.3
Kakuda, S.4
Haltiwanger, R.S.5
Gossler, A.6
-
73
-
-
0024377258
-
Identification of a disaccharide (Xyl-Glc) and a trisaccharide (Xyl2-Glc) O-glycosidically linked to a serine residue in the first epidermal growth factor-like domain of human factors VII and IX and protein Z and bovine protein Z
-
Nishimura H, Kawabata S, Kisiel W, Hase S, Ikenaka T, Takao T, Shimonishi Y, Iwanaga S (1989) Identification of a disaccharide (Xyl-Glc) and a trisaccharide (Xyl2-Glc) O-glycosidically linked to a serine residue in the first epidermal growth factor-like domain of human factors VII and IX and protein Z and bovine protein Z. J Biol Chem 264(34):20320–20325
-
(1989)
J Biol Chem
, vol.264
, Issue.34
, pp. 20320-20325
-
-
Nishimura, H.1
Kawabata, S.2
Kisiel, W.3
Hase, S.4
Ikenaka, T.5
Takao, T.6
Shimonishi, Y.7
Iwanaga, S.8
-
74
-
-
84921790705
-
Impaired O-linked N-acetylglucosaminylation in the endoplasmic reticulum by mutated epidermal growth factor (EGF) domain-specific O-linked N-acetylglucosamine transferase found in Adams-Oliver syndrome
-
Ogawa M, Sawaguchi S, Kawai T, Nadano D, Matsuda T, Yagi H, Kato K, Furukawa K, Okajima T (2015) Impaired O-linked N-acetylglucosaminylation in the endoplasmic reticulum by mutated epidermal growth factor (EGF) domain-specific O-linked N-acetylglucosamine transferase found in Adams-Oliver syndrome. J Biol Chem 290(4):2137–2149. https://doi.org/10.1074/jbc.M114.598821
-
(2015)
J Biol Chem
, vol.290
, Issue.4
, pp. 2137-2149
-
-
Ogawa, M.1
Sawaguchi, S.2
Kawai, T.3
Nadano, D.4
Matsuda, T.5
Yagi, H.6
Kato, K.7
Furukawa, K.8
Okajima, T.9
-
75
-
-
0037074006
-
Regulation of notch signaling by o-linked fucose
-
Okajima T, Irvine KD (2002) Regulation of notch signaling by o-linked fucose. Cell 111(6):893–904
-
(2002)
Cell
, vol.111
, Issue.6
, pp. 893-904
-
-
Okajima, T.1
Irvine, K.D.2
-
76
-
-
14844355836
-
Chaperone activity of protein O-fucosyltransferase 1 promotes notch receptor folding
-
Okajima T, Xu A, Lei L, Irvine KD (2005) Chaperone activity of protein O-fucosyltransferase 1 promotes notch receptor folding. Science 307(5715):1599– 1603. https://doi.org/10.1126/science.1108995
-
(2005)
Science
, vol.307
, Issue.5715
, pp. 1599-1603
-
-
Okajima, T.1
Xu, A.2
Lei, L.3
Irvine, K.D.4
-
77
-
-
47549092347
-
Pofut1 is required for the proper localization of the Notch receptor during mouse development
-
Okamura Y, Saga Y (2008) Pofut1 is required for the proper localization of the Notch receptor during mouse development. Mech Dev 125(8):663–673. https://doi. org/10.1016/j.mod.2008.04.007
-
(2008)
Mech Dev
, vol.125
, Issue.8
, pp. 663-673
-
-
Okamura, Y.1
Saga, Y.2
-
78
-
-
0030756962
-
Fringe modulates Notch-ligand interactions
-
Panin VM, Papayannopoulos V, Wilson R, Irvine KD (1997) Fringe modulates Notch-ligand interactions. Nature 387(6636):908–912. https://doi. org/10.1038/43191
-
(1997)
Nature
, vol.387
, Issue.6636
, pp. 908-912
-
-
Panin, V.M.1
Papayannopoulos, V.2
Wilson, R.3
Irvine, K.D.4
-
79
-
-
84946594140
-
Protein O-Glucosyltransferase 1 (POGLUT1) promotes mouse gastrulation through modification of the apical polarity protein CRUMBS2
-
Ramkumar N, Harvey BM, Lee JD, Alcorn HL, Silva-Gagliardi NF, McGlade CJ, Bestor TH, Wijnholds J, Haltiwanger RS, Anderson KV (2015) Protein O-Glucosyltransferase 1 (POGLUT1) promotes mouse gastrulation through modification of the apical polarity protein CRUMBS2. PLoS Genet 11(10):e1005551. https://doi.org/10.1371/journal.pgen.1005551
-
(2015)
Plos Genet
, vol.11
, Issue.10
-
-
Ramkumar, N.1
Harvey, B.M.2
Lee, J.D.3
Alcorn, H.L.4
Silva-Gagliardi, N.F.5
McGlade, C.J.6
Bestor, T.H.7
Wijnholds, J.8
Haltiwanger, R.S.9
Anderson, K.V.10
-
80
-
-
25444492595
-
Highly conserved O-fucose sites have distinct effects on Notch1 function
-
Rampal R, Arboleda-Velasquez JF, Nita-Lazar A, Kosik KS, Haltiwanger RS (2005) Highly conserved O-fucose sites have distinct effects on Notch1 function. J Biol Chem 280(37):32133–32140. https://doi. org/10.1074/jbc.M506104200
-
(2005)
J Biol Chem
, vol.280
, Issue.37
, pp. 32133-32140
-
-
Rampal, R.1
Arboleda-Velasquez, J.F.2
Nita-Lazar, A.3
Kosik, K.S.4
Haltiwanger, R.S.5
-
81
-
-
34250878429
-
Notch signaling in normal and disease states: Possible therapies related to glycosylation
-
Rampal R, Luther KB, Haltiwanger RS (2007) Notch signaling in normal and disease states: possible therapies related to glycosylation. Curr Mol Med 7(4):427–445
-
(2007)
Curr Mol Med
, vol.7
, Issue.4
, pp. 427-445
-
-
Rampal, R.1
Luther, K.B.2
Haltiwanger, R.S.3
-
82
-
-
80053570445
-
Fringe benefits: Functional and structural impacts of O-glycosylation on the extracellular domain of Notch receptors
-
Rana NA, Haltiwanger RS (2011) Fringe benefits: functional and structural impacts of O-glycosylation on the extracellular domain of Notch receptors. Curr Opin Struct Biol 21(5):583–589. https://doi.org/10.1016/j. sbi.2011.08.008
-
(2011)
Curr Opin Struct Biol
, vol.21
, Issue.5
, pp. 583-589
-
-
Rana, N.A.1
Haltiwanger, R.S.2
-
83
-
-
80052422050
-
O-glucose trisaccharide is present at high but variable stoichiometry at multiple sites on mouse Notch1
-
Rana NA, Nita-Lazar A, Takeuchi H, Kakuda S, Luther KB, Haltiwanger RS (2011) O-glucose trisaccharide is present at high but variable stoichiometry at multiple sites on mouse Notch1. J Biol Chem 286(36):31623– 31637. https://doi.org/10.1074/jbc.M111.268243
-
(2011)
J Biol Chem
, vol.286
, Issue.36
, pp. 31623-31637
-
-
Rana, N.A.1
Nita-Lazar, A.2
Takeuchi, H.3
Kakuda, S.4
Luther, K.B.5
Haltiwanger, R.S.6
-
84
-
-
0026086474
-
Specific EGF repeats of Notch mediate interactions with Delta and Serrate: Implications for Notch as a multifunctional receptor
-
Rebay I, Fleming RJ, Fehon RG, Cherbas L, Cherbas P, Artavanis-Tsakonas S (1991) Specific EGF repeats of Notch mediate interactions with Delta and Serrate: implications for Notch as a multifunctional receptor. Cell 67(4):687–699
-
(1991)
Cell
, vol.67
, Issue.4
, pp. 687-699
-
-
Rebay, I.1
Fleming, R.J.2
Fehon, R.G.3
Cherbas, L.4
Cherbas, P.5
Artavanis-Tsakonas, S.6
-
85
-
-
58149396934
-
Bile duct proliferation in Jag1/fringe heterozygous mice identifies candidate modifiers of the Alagille syndrome hepatic phenotype
-
Ryan MJ, Bales C, Nelson A, Gonzalez DM, Underkoffler L, Segalov M, Wilson-Rawls J, Cole SE, Moran JL, Russo P, Spinner NB, Kusumi K, Loomes KM (2008) Bile duct proliferation in Jag1/fringe heterozygous mice identifies candidate modifiers of the Alagille syndrome hepatic phenotype. Hepatology 48(6):1989– 1997. https://doi.org/10.1002/hep.22538
-
(2008)
Hepatology
, vol.48
, Issue.6
, pp. 1989-1997
-
-
Ryan, M.J.1
Bales, C.2
Nelson, A.3
Gonzalez, D.M.4
Underkoffler, L.5
Segalov, M.6
Wilson-Rawls, J.7
Cole, S.E.8
Moran, J.L.9
Russo, P.10
Spinner, N.B.11
Kusumi, K.12
Loomes, K.M.13
-
86
-
-
84455194250
-
O-linked-N-acetylglucosamine on extracellular protein domains mediates epithelial cell-matrix interactions
-
Sakaidani Y, Nomura T, Matsuura A, Ito M, Suzuki E, Murakami K, Nadano D, Matsuda T, Furukawa K, Okajima T (2011) O-linked-N-acetylglucosamine on extracellular protein domains mediates epithelial cell-matrix interactions. Nat Commun 2:583. https://doi. org/10.1038/ncomms1591
-
(2011)
Nat Commun
, vol.2
, pp. 583
-
-
Sakaidani, Y.1
Nomura, T.2
Matsuura, A.3
Ito, M.4
Suzuki, E.5
Murakami, K.6
Nadano, D.7
Matsuda, T.8
Furukawa, K.9
Okajima, T.10
-
87
-
-
84857658880
-
O-linked-N-acetylglucosamine modification of mammalian Notch receptors by an atypical O-GlcNAc transferase Eogt1
-
Sakaidani Y, Ichiyanagi N, Saito C, Nomura T, Ito M, Nishio Y, Nadano D, Matsuda T, Furukawa K, Okajima T (2012) O-linked-N-acetylglucosamine modification of mammalian Notch receptors by an atypical O-GlcNAc transferase Eogt1. Biochem Biophys Res Commun 419(1):14–19. https://doi. org/10.1016/j.bbrc.2012.01.098
-
(2012)
Biochem Biophys Res Commun
, vol.419
, Issue.1
, pp. 14-19
-
-
Sakaidani, Y.1
Ichiyanagi, N.2
Saito, C.3
Nomura, T.4
Ito, M.5
Nishio, Y.6
Nadano, D.7
Matsuda, T.8
Furukawa, K.9
Okajima, T.10
-
88
-
-
85017556517
-
O-GlcNAc on NOTCH1 EGF repeats regulates ligand-induced Notch signaling and vascular development in mammals
-
Sawaguchi S, Varshney S, Ogawa M, Sakaidani Y, Yagi H, Takeshita K, Murohara T, Kato K, Sundaram S, Stanley P, Okajima T (2017) O-GlcNAc on NOTCH1 EGF repeats regulates ligand-induced Notch signaling and vascular development in mammals. elife 6. https://doi.org/10.7554/eLife.24419
-
(2017)
Elife
, vol.6
-
-
Sawaguchi, S.1
Varshney, S.2
Ogawa, M.3
Sakaidani, Y.4
Yagi, H.5
Takeshita, K.6
Murohara, T.7
Kato, K.8
Sundaram, S.9
Stanley, P.10
Okajima, T.11
-
89
-
-
79952497178
-
Identification of a therapeutic strategy targeting amplified FGF19 in liver cancer by Oncogenomic screening
-
Sawey ET, Chanrion M, Cai C, Wu G, Zhang J, Zender L, Zhao A, Busuttil RW, Yee H, Stein L, French DM, Finn RS, Lowe SW, Powers S (2011) Identification of a therapeutic strategy targeting amplified FGF19 in liver cancer by Oncogenomic screening. Cancer Cell 19(3):347–358. https://doi.org/10.1016/j. ccr.2011.01.040
-
(2011)
Cancer Cell
, vol.19
, Issue.3
, pp. 347-358
-
-
Sawey, E.T.1
Chanrion, M.2
Cai, C.3
Wu, G.4
Zhang, J.5
Zender, L.6
Zhao, A.7
Busuttil, R.W.8
Yee, H.9
Stein, L.10
French, D.M.11
Finn, R.S.12
Lowe, S.W.13
Powers, S.14
-
90
-
-
85021733463
-
-
In Review
-
Schneider M, Kumar V, Nordstrom LU, Feng L, Takeuchi H, Stanley P, Wu P, Haltiwanger RS. Inhibition of Delta-induced Notch signaling using fucose analogs (In Review).
-
Inhibition of Delta-Induced Notch Signaling Using Fucose Analogs
-
-
Schneider, M.1
Kumar, V.2
Nordstrom, L.U.3
Feng, L.4
Takeuchi, H.5
Stanley, P.6
Wu, P.7
Haltiwanger, R.S.8
-
91
-
-
84990981830
-
A POGLUT1 mutation causes a muscular dystrophy with reduced Notch signaling and satellite cell loss
-
Servian-Morilla E, Takeuchi H, Lee TV, Clarimon J, Mavillard F, Area-Gomez E, Rivas E, Nieto-Gonzalez JL, Rivero MC, Cabrera-Serrano M, Gomez-Sanchez L, Martinez-Lopez JA, Estrada B, Marquez C, Morgado Y, Suarez-Calvet X, Pita G, Bigot A, Gallardo E, Fernandez-Chacon R, Hirano M, Haltiwanger RS, Jafar-Nejad H, Paradas C (2016) A POGLUT1 mutation causes a muscular dystrophy with reduced Notch signaling and satellite cell loss. EMBO Mol Med 8(11):1289–1309. https://doi.org/10.15252/emmm.201505815
-
(2016)
EMBO Mol Med
, vol.8
, Issue.11
, pp. 1289-1309
-
-
Servian-Morilla, E.1
Takeuchi, H.2
Lee, T.V.3
Clarimon, J.4
Mavillard, F.5
Area-Gomez, E.6
Rivas, E.7
Nieto-Gonzalez, J.L.8
Rivero, M.C.9
Cabrera-Serrano, M.10
Gomez-Sanchez, L.11
Martinez-Lopez, J.A.12
Estrada, B.13
Marquez, C.14
Morgado, Y.15
Suarez-Calvet, X.16
Pita, G.17
Bigot, A.18
Gallardo, E.19
Fernandez-Chacon, R.20
Hirano, M.21
Haltiwanger, R.S.22
Jafar-Nejad, H.23
Paradas, C.24
more..
-
92
-
-
76249087224
-
Identification of glycosyltransferase 8 family members as xylosyltransferases acting on O-glucosylated notch epidermal growth factor repeats
-
Sethi MK, Buettner FF, Krylov VB, Takeuchi H, Nifantiev NE, Haltiwanger RS, Gerardy-Schahn R, Bakker H (2010) Identification of glycosyltransferase 8 family members as xylosyltransferases acting on O-glucosylated notch epidermal growth factor repeats. J Biol Chem 285(3):1582–1586. https://doi. org/10.1074/jbc.C109.065409
-
(2010)
J Biol Chem
, vol.285
, Issue.3
, pp. 1582-1586
-
-
Sethi, M.K.1
Buettner, F.F.2
Krylov, V.B.3
Takeuchi, H.4
Nifantiev, N.E.5
Haltiwanger, R.S.6
Gerardy-Schahn, R.7
Bakker, H.8
-
93
-
-
84856070820
-
Molecular cloning of a xylosyltransferase that transfers the second xylose to O-glucosylated epidermal growth factor repeats of notch
-
Sethi MK, Buettner FF, Ashikov A, Krylov VB, Takeuchi H, Nifantiev NE, Haltiwanger RS, Gerardy-Schahn R, Bakker H (2012) Molecular cloning of a xylosyltransferase that transfers the second xylose to O-glucosylated epidermal growth factor repeats of notch. J Biol Chem 287(4):2739–2748. https://doi. org/10.1074/jbc.M111.302406
-
(2012)
J Biol Chem
, vol.287
, Issue.4
, pp. 2739-2748
-
-
Sethi, M.K.1
Buettner, F.F.2
Ashikov, A.3
Krylov, V.B.4
Takeuchi, H.5
Nifantiev, N.E.6
Haltiwanger, R.S.7
Gerardy-Schahn, R.8
Bakker, H.9
-
94
-
-
84875917005
-
Mutations in EOGT confirm the genetic heterogeneity of autosomal-recessive Adams-Oliver syndrome
-
Shaheen R, Aglan M, Keppler-Noreuil K, Faqeih E, Ansari S, Horton K, Ashour A, Zaki MS, Al-Zahrani F, Cueto-Gonzalez AM, Abdel-Salam G, Temtamy S, Alkuraya FS (2013) Mutations in EOGT confirm the genetic heterogeneity of autosomal-recessive Adams-Oliver syndrome. Am J Hum Genet 92(4):598–604. https://doi.org/10.1016/j.ajhg.2013.02.012
-
(2013)
Am J Hum Genet
, vol.92
, Issue.4
, pp. 598-604
-
-
Shaheen, R.1
Aglan, M.2
Keppler-Noreuil, K.3
Faqeih, E.4
Ansari, S.5
Horton, K.6
Ashour, A.7
Zaki, M.S.8
Al-Zahrani, F.9
Cueto-Gonzalez, A.M.10
Abdel-Salam, G.11
Temtamy, S.12
Alkuraya, F.S.13
-
95
-
-
0037424256
-
Fringe modifies O-fucose on mouse Notch1 at epidermal growth factor-like repeats within the ligand-binding site and the Abruptex region
-
Shao L, Moloney DJ, Haltiwanger R (2003) Fringe modifies O-fucose on mouse Notch1 at epidermal growth factor-like repeats within the ligand-binding site and the Abruptex region. J Biol Chem 278(10):7775–7782. https://doi.org/10.1074/jbc.M212221200
-
(2003)
J Biol Chem
, vol.278
, Issue.10
, pp. 7775-7782
-
-
Shao, L.1
Moloney, D.J.2
Haltiwanger, R.3
-
96
-
-
0037547158
-
Protein O-fucosyltransferase 1 is an essential component of Notch signaling pathways
-
Shi S, Stanley P (2003) Protein O-fucosyltransferase 1 is an essential component of Notch signaling pathways. Proc Natl Acad Sci U S A 100(9):5234–5239. https://doi.org/10.1073/pnas.0831126100
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, Issue.9
, pp. 5234-5239
-
-
Shi, S.1
Stanley, P.2
-
97
-
-
34547111586
-
The threonine that carries fucose, but not fucose, is required for Cripto to facilitate Nodal signaling
-
Shi S, Ge C, Luo Y, Hou X, Haltiwanger RS, Stanley P (2007) The threonine that carries fucose, but not fucose, is required for Cripto to facilitate Nodal signaling. J Biol Chem 282(28):20133–20141. https://doi.org/10.1074/jbc.M702593200
-
(2007)
J Biol Chem
, vol.282
, Issue.28
, pp. 20133-20141
-
-
Shi, S.1
Ge, C.2
Luo, Y.3
Hou, X.4
Haltiwanger, R.S.5
Stanley, P.6
-
98
-
-
84953314268
-
Lunatic, manic, and radical fringe each promote T and B cell development
-
Song Y, Kumar V, Wei HX, Qiu J, Stanley P (2016) Lunatic, manic, and radical fringe each promote T and B cell development. J Immunol 196(1):232–243. https://doi.org/10.4049/jimmunol.1402421
-
(2016)
J Immunol
, vol.196
, Issue.1
, pp. 232-243
-
-
Song, Y.1
Kumar, V.2
Wei, H.X.3
Qiu, J.4
Stanley, P.5
-
99
-
-
29244458644
-
Mutation of the LUNATIC FRINGE gene in humans causes spondylocostal dysostosis with a severe vertebral phenotype
-
Sparrow DB, Chapman G, Wouters MA, Whittock NV, Ellard S, Fatkin D, Turnpenny PD, Kusumi K, Sillence D, Dunwoodie SL (2006) Mutation of the LUNATIC FRINGE gene in humans causes spondylocostal dysostosis with a severe vertebral phenotype. Am J Hum Genet 78(1):28–37. https://doi.org/10.1086/498879
-
(2006)
Am J Hum Genet
, vol.78
, Issue.1
, pp. 28-37
-
-
Sparrow, D.B.1
Chapman, G.2
Wouters, M.A.3
Whittock, N.V.4
Ellard, S.5
Fatkin, D.6
Turnpenny, P.D.7
Kusumi, K.8
Sillence, D.9
Dunwoodie, S.L.10
-
100
-
-
44049101200
-
Roles of Pofut1 and O-fucose in mammalian notch signaling
-
Stahl M, Uemura K, Ge C, Shi S, Tashima Y, Stanley P (2008) Roles of Pofut1 and O-fucose in mammalian notch signaling. J Biol Chem 283(20):13638–13651. https://doi.org/10.1074/jbc.M802027200
-
(2008)
J Biol Chem
, vol.283
, Issue.20
, pp. 13638-13651
-
-
Stahl, M.1
Uemura, K.2
Ge, C.3
Shi, S.4
Tashima, Y.5
Stanley, P.6
-
101
-
-
84908251771
-
Mutations in NOTCH1 cause Adams-Oliver syndrome
-
Stittrich AB, Lehman A, Bodian DL, Ashworth J, Zong Z, Li H, Lam P, Khromykh A, Iyer RK, Vockley JG, Baveja R, Silva ES, Dixon J, Leon EL, Solomon BD, Glusman G, Niederhuber JE, Roach JC, Patel MS (2014) Mutations in NOTCH1 cause Adams-Oliver syndrome. Am J Hum Genet 95(3):275–284. https://doi.org/10.1016/j.ajhg.2014.07.011
-
(2014)
Am J Hum Genet
, vol.95
, Issue.3
, pp. 275-284
-
-
Stittrich, A.B.1
Lehman, A.2
Bodian, D.L.3
Ashworth, J.4
Zong, Z.5
Li, H.6
Lam, P.7
Khromykh, A.8
Iyer, R.K.9
Vockley, J.G.10
Baveja, R.11
Silva, E.S.12
Dixon, J.13
Leon, E.L.14
Solomon, B.D.15
Glusman, G.16
Niederhuber, J.E.17
Roach, J.C.18
Patel, M.S.19
-
102
-
-
64649093843
-
MFng is dispensable for mouse pancreas development and function
-
Svensson P, Bergqvist I, Norlin S, Edlund H (2009) MFng is dispensable for mouse pancreas development and function. Mol Cell Biol 29(8):2129–2138. https://doi. org/10.1128/MCB.01644-08
-
(2009)
Mol Cell Biol
, vol.29
, Issue.8
, pp. 2129-2138
-
-
Svensson, P.1
Bergqvist, I.2
Norlin, S.3
Edlund, H.4
-
103
-
-
80053634225
-
Rumi functions as both a protein O-glucosyltransferase and a protein O-xylosyltransferase
-
Takeuchi H, Fernandez-Valdivia RC, Caswell DS, Nita-Lazar A, Rana NA, Garner TP, Weldeghiorghis TK, Macnaughtan MA, Jafar-Nejad H, Haltiwanger RS (2011) Rumi functions as both a protein O-glucosyltransferase and a protein O-xylosyltransferase. Proc Natl Acad Sci U S A 108(40):16600–16605. https://doi.org/10.1073/pnas.1109696108
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, Issue.40
, pp. 16600-16605
-
-
Takeuchi, H.1
Fernandez-Valdivia, R.C.2
Caswell, D.S.3
Nita-Lazar, A.4
Rana, N.A.5
Garner, T.P.6
Weldeghiorghis, T.K.7
Macnaughtan, M.A.8
Jafar-Nejad, H.9
Haltiwanger, R.S.10
-
104
-
-
84867257213
-
Site-specific O-glucosylation of the epidermal growth factor-like (EGF) repeats of notch: Efficiency of glycosylation is affected by proper folding and amino acid sequence of individual EGF repeats
-
Takeuchi H, Kantharia J, Sethi MK, Bakker H, Haltiwanger RS (2012) Site-specific O-glucosylation of the epidermal growth factor-like (EGF) repeats of notch: efficiency of glycosylation is affected by proper folding and amino acid sequence of individual EGF repeats. J Biol Chem 287(41):33934–33944. https://doi.org/10.1074/jbc.M112.401315
-
(2012)
J Biol Chem
, vol.287
, Issue.41
, pp. 33934-33944
-
-
Takeuchi, H.1
Kantharia, J.2
Sethi, M.K.3
Bakker, H.4
Haltiwanger, R.S.5
-
105
-
-
84901045153
-
Fringe-mediated extension of O-linked fucose in the ligand-binding region of Notch1 increases binding to mammalian Notch ligands
-
Taylor P, Takeuchi H, Sheppard D, Chillakuri C, Lea SM, Haltiwanger RS, Handford PA (2014) Fringe-mediated extension of O-linked fucose in the ligand-binding region of Notch1 increases binding to mammalian Notch ligands. Proc Natl Acad Sci U S A 111(20):7290–7295. https://doi.org/10.1073/pnas.1319683111
-
(2014)
Proc Natl Acad Sci U S A
, vol.111
, Issue.20
, pp. 7290-7295
-
-
Taylor, P.1
Takeuchi, H.2
Sheppard, D.3
Chillakuri, C.4
Lea, S.M.5
Haltiwanger, R.S.6
Handford, P.A.7
-
106
-
-
84956815794
-
Jagged1 heterozygosity in mice results in a congenital cholangiopathy which is reversed by concomitant deletion of one copy of Poglut1 (Rumi)
-
Thakurdas SM, Lopez MF, Kakuda S, Fernandez-Valdivia R, Zarrin-Khameh N, Haltiwanger RS, Jafar-Nejad H (2016) Jagged1 heterozygosity in mice results in a congenital cholangiopathy which is reversed by concomitant deletion of one copy of Poglut1 (Rumi). Hepatology 63(2):550–565. https://doi.org/10.1002/hep.28024
-
(2016)
Hepatology
, vol.63
, Issue.2
, pp. 550-565
-
-
Thakurdas, S.M.1
Lopez, M.F.2
Kakuda, S.3
Fernandez-Valdivia, R.4
Zarrin-Khameh, N.5
Haltiwanger, R.S.6
Jafar-Nejad, H.7
-
107
-
-
0021280147
-
Topography and polypeptide distribution of terminal N-acetylglucosamine residues on the surfaces of intact lymphocytes. Evidence for O-linked GlcNAc
-
Torres CR, Hart GW (1984) Topography and polypeptide distribution of terminal N-acetylglucosamine residues on the surfaces of intact lymphocytes. Evidence for O-linked GlcNAc. J Biol Chem 259(5):3308–3317
-
(1984)
J Biol Chem
, vol.259
, Issue.5
, pp. 3308-3317
-
-
Torres, C.R.1
Hart, G.W.2
-
108
-
-
84926668745
-
Novel roles for O-linked glycans in protein folding
-
Vasudevan D, Haltiwanger RS (2014) Novel roles for O-linked glycans in protein folding. Glycoconj J 31(6–7):417–426. https://doi.org/10.1007/s10719-014-9556-4
-
(2014)
Glycoconj J
, vol.31
, Issue.6-7
, pp. 417-426
-
-
Vasudevan, D.1
Haltiwanger, R.S.2
-
109
-
-
84958117778
-
The many roles of Notch signaling during vertebrate somitogenesis
-
Wahi K, Bochter MS, Cole SE (2016) The many roles of Notch signaling during vertebrate somitogenesis. Semin Cell Dev Biol 49:68–75. https://doi. org/10.1016/j.semcdb.2014.11.010
-
(2016)
Semin Cell Dev Biol
, vol.49
, pp. 68-75
-
-
Wahi, K.1
Bochter, M.S.2
Cole, S.E.3
-
110
-
-
0032478730
-
Purification and characterization of a GDP-fucose:Polypeptide fucosyltransferase from Chinese hamster ovary cells
-
Wang Y, Spellman MW (1998) Purification and characterization of a GDP-fucose:polypeptide fucosyltransferase from Chinese hamster ovary cells. J Biol Chem 273(14):8112–8118
-
(1998)
J Biol Chem
, vol.273
, Issue.14
, pp. 8112-8118
-
-
Wang, Y.1
Spellman, M.W.2
-
111
-
-
0030472840
-
Identification of a GDP-L-fucose:Polypeptide fucosyltransferase and enzymatic addition of O-linked fucose to EGF domains
-
Wang Y, Lee GF, Kelley RF, Spellman MW (1996) Identification of a GDP-L-fucose:polypeptide fucosyltransferase and enzymatic addition of O-linked fucose to EGF domains. Glycobiology 6(8):837–842
-
(1996)
Glycobiology
, vol.6
, Issue.8
, pp. 837-842
-
-
Wang, Y.1
Lee, G.F.2
Kelley, R.F.3
Spellman, M.W.4
-
112
-
-
0035955684
-
Modification of epidermal growth factor-like repeats with O-fucose Molecular cloning and expression of a novel GDP-fucose protein O-fucosyltransferase
-
Wang Y, Shao L, Shi S, Harris RJ, Spellman MW, Stanley P, Haltiwanger RS (2001) Modification of epidermal growth factor-like repeats with O-fucose Molecular cloning and expression of a novel GDP-fucose protein O-fucosyltransferase. J Biol Chem 276(43):40338– 40345. https://doi.org/10.1074/jbc.M107849200
-
(2001)
J Biol Chem
, vol.276
, Issue.43
, pp. 40338-40345
-
-
Wang, Y.1
Shao, L.2
Shi, S.3
Harris, R.J.4
Spellman, M.W.5
Stanley, P.6
Haltiwanger, R.S.7
-
113
-
-
76949088829
-
Overexpression of human CAP10-like protein 46 KD in T-acute lymphoblastic leukemia and acute myelogenous leukemia
-
Wang Y, Chang N, Zhang T, Liu H, Ma W, Chu Q, Lai Q, Liu L, Wang W (2010) Overexpression of human CAP10-like protein 46 KD in T-acute lymphoblastic leukemia and acute myelogenous leukemia. Genet Test Mol Biomarkers 14(1):127–133. https://doi. org/10.1089/gtmb.2009.0145
-
(2010)
Genet Test Mol Biomarkers
, vol.14
, Issue.1
, pp. 127-133
-
-
Wang, Y.1
Chang, N.2
Zhang, T.3
Liu, H.4
Ma, W.5
Chu, Q.6
Lai, Q.7
Liu, L.8
Wang, W.9
-
114
-
-
0344824688
-
Modulation of notch signaling during somitogenesis
-
Weinmaster G, Kintner C (2003) Modulation of notch signaling during somitogenesis. Annu Rev Cell Dev Biol 19:367–395. https://doi.org/10.1146/annurev. cellbio.19.111301.115434
-
(2003)
Annu Rev Cell Dev Biol
, vol.19
, pp. 367-395
-
-
Weinmaster, G.1
Kintner, C.2
-
115
-
-
24044436824
-
Regions of Drosophila Notch that contribute to ligand binding and the modula-tory influence of Fringe
-
Xu A, Lei L, Irvine KD (2005) Regions of Drosophila Notch that contribute to ligand binding and the modula-tory influence of Fringe. J Biol Chem 280(34):30158– 30165. https://doi.org/10.1074/jbc.M505569200
-
(2005)
J Biol Chem
, vol.280
, Issue.34
, pp. 30158-30165
-
-
Xu, A.1
Lei, L.2
Irvine, K.D.3
-
116
-
-
36849042494
-
In vitro reconsti-tution of the modulation of Drosophila Notch-ligand binding by Fringe
-
Xu A, Haines N, Dlugosz M, Rana NA, Takeuchi H, Haltiwanger RS, Irvine KD (2007) In vitro reconsti-tution of the modulation of Drosophila Notch-ligand binding by Fringe. J Biol Chem 282(48):35153– 35162. https://doi.org/10.1074/jbc.M707040200
-
(2007)
J Biol Chem
, vol.282
, Issue.48
, pp. 35153-35162
-
-
Xu, A.1
Haines, N.2
Dlugosz, M.3
Rana, N.A.4
Takeuchi, H.5
Haltiwanger, R.S.6
Irvine, K.D.7
-
117
-
-
84861398396
-
Lunatic fringe deficiency cooperates with the Met/Caveolin gene amplicon to induce basal-like breast cancer
-
Xu K, Usary J, Kousis PC, Prat A, Wang DY, Adams JR, Wang W, Loch AJ, Deng T, Zhao W, Cardiff RD, Yoon K, Gaiano N, Ling V, Beyene J, Zacksenhaus E, Gridley T, Leong WL, Guidos CJ, Perou CM, Egan SE (2012) Lunatic fringe deficiency cooperates with the Met/Caveolin gene amplicon to induce basal-like breast cancer. Cancer Cell 21(5):626–641. https://doi. org/10.1016/j.ccr.2012.03.041
-
(2012)
Cancer Cell
, vol.21
, Issue.5
, pp. 626-641
-
-
Xu, K.1
Usary, J.2
Kousis, P.C.3
Prat, A.4
Wang, D.Y.5
Adams, J.R.6
Wang, W.7
Loch, A.J.8
Deng, T.9
Zhao, W.10
Cardiff, R.D.11
Yoon, K.12
Gaiano, N.13
Ling, V.14
Beyene, J.15
Zacksenhaus, E.16
Gridley, T.17
Leong, W.L.18
Guidos, C.J.19
Perou, C.M.20
Egan, S.E.21
more..
-
118
-
-
12944255642
-
Fringe glycosyltransferases differentially modulate Notch1 proteolysis induced by Delta1 and Jagged1
-
Yang LT, Nichols JT, Yao C, Manilay JO, Robey EA, Weinmaster G (2005) Fringe glycosyltransferases differentially modulate Notch1 proteolysis induced by Delta1 and Jagged1. Mol Biol Cell 16(2):927–942. https://doi.org/10.1091/mbc.E04-07-0614
-
(2005)
Mol Biol Cell
, vol.16
, Issue.2
, pp. 927-942
-
-
Yang, L.T.1
Nichols, J.T.2
Yao, C.3
Manilay, J.O.4
Robey, E.A.5
Weinmaster, G.6
-
119
-
-
79957607092
-
Protein O-fucosyltransferase 1 (Pofut1) regulates lymphoid and myeloid homeostasis through modulation of Notch receptor ligand interactions
-
Yao D, Huang Y, Huang X, Wang W, Yan Q, Wei L, Xin W, Gerson S, Stanley P, Lowe JB, Zhou L (2011) Protein O-fucosyltransferase 1 (Pofut1) regulates lymphoid and myeloid homeostasis through modulation of Notch receptor ligand interactions. Blood 117(21):5652– 5662. https://doi.org/10.1182/blood-2010-12-326074
-
(2011)
Blood
, vol.117
, Issue.21
, pp. 5652-5662
-
-
Yao, D.1
Huang, Y.2
Huang, X.3
Wang, W.4
Yan, Q.5
Wei, L.6
Xin, W.7
Gerson, S.8
Stanley, P.9
Lowe, J.B.10
Zhou, L.11
-
120
-
-
84892176142
-
Protein O-fucosyltransferase 1: A potential diagnostic marker and therapeutic target for human oral cancer
-
Yokota S, Ogawara K, Kimura R, Shimizu F, Baba T, Minakawa Y, Higo M, Kasamatsu A, Endo-Sakamoto Y, Shiiba M, Tanzawa H, Uzawa K (2013) Protein O-fucosyltransferase 1: a potential diagnostic marker and therapeutic target for human oral cancer. Int J Oncol 43(6):1864–1870. https://doi.org/10.3892/ijo.2013.2110
-
(2013)
Int J Oncol
, vol.43
, Issue.6
, pp. 1864-1870
-
-
Yokota, S.1
Ogawara, K.2
Kimura, R.3
Shimizu, F.4
Baba, T.5
Minakawa, Y.6
Higo, M.7
Kasamatsu, A.8
Endo-Sakamoto, Y.9
Shiiba, M.10
Tanzawa, H.11
Uzawa, K.12
-
121
-
-
84945290553
-
Notch-modifying xylosyltransferase structures support an SNi-like retaining mechanism
-
Yu H, Takeuchi M, LeBarron J, Kantharia J, London E, Bakker H, Haltiwanger RS, Li H, Takeuchi H (2015) Notch-modifying xylosyltransferase structures support an SNi-like retaining mechanism. Nat Chem Biol 11(11):847–854. https://doi.org/10.1038/nchembio.1927
-
(2015)
Nat Chem Biol
, vol.11
, Issue.11
, pp. 847-854
-
-
Yu, H.1
Takeuchi, M.2
Lebarron, J.3
Kantharia, J.4
London, E.5
Bakker, H.6
Haltiwanger, R.S.7
Li, H.8
Takeuchi, H.9
-
122
-
-
84978760284
-
Structural analysis of Notch-regulating Rumi reveals basis for pathogenic mutations
-
Yu H, Takeuchi H, Takeuchi M, Liu Q, Kantharia J, Haltiwanger RS, Li H (2016) Structural analysis of Notch-regulating Rumi reveals basis for pathogenic mutations. Nat Chem Biol 12(9):735–740. https://doi. org/10.1038/nchembio.2135
-
(2016)
Nat Chem Biol
, vol.12
, Issue.9
, pp. 735-740
-
-
Yu, H.1
Takeuchi, H.2
Takeuchi, M.3
Liu, Q.4
Kantharia, J.5
Haltiwanger, R.S.6
Li, H.7
-
123
-
-
0036267319
-
Segmentation defects of Notch pathway mutants and absence of a synergistic phenotype in lunatic fringe/radical fringe double mutant mice
-
Zhang N, Norton CR, Gridley T (2002) Segmentation defects of Notch pathway mutants and absence of a synergistic phenotype in lunatic fringe/radical fringe double mutant mice. Genesis 33(1):21–28. https://doi. org/10.1002/gene.10081
-
(2002)
Genesis
, vol.33
, Issue.1
, pp. 21-28
-
-
Zhang, N.1
Norton, C.R.2
Gridley, T.3
-
124
-
-
84900446105
-
Tumor-suppressive activity of Lunatic Fringe in prostate through differential modulation of Notch receptor activation
-
Zhang S, Chung WC, Wu G, Egan SE, Xu K (2014) Tumor-suppressive activity of Lunatic Fringe in prostate through differential modulation of Notch receptor activation. Neoplasia 16(2):158–167. https://doi. org/10.1593/neo.131870
-
(2014)
Neoplasia
, vol.16
, Issue.2
, pp. 158-167
-
-
Zhang, S.1
Chung, W.C.2
Wu, G.3
Egan, S.E.4
Xu, K.5
-
125
-
-
84942869368
-
Manic fringe promotes a claudin-low breast cancer phenotype through notch-mediated PIK3CG induction
-
Zhang S, Chung WC, Wu G, Egan SE, Miele L, Xu K (2015) Manic fringe promotes a claudin-low breast cancer phenotype through notch-mediated PIK3CG induction. Cancer Res 75(10):1936–1943. https://doi. org/10.1158/0008-5472.CAN-14-3303
-
(2015)
Cancer Res
, vol.75
, Issue.10
, pp. 1936-1943
-
-
Zhang, S.1
Chung, W.C.2
Wu, G.3
Egan, S.E.4
Miele, L.5
Xu, K.6
-
126
-
-
84939448511
-
Lunatic Fringe is a potent tumor suppressor in Kras-initiated pancreatic cancer
-
Zhang S, Chung WC, Xu K (2016) Lunatic Fringe is a potent tumor suppressor in Kras-initiated pancreatic cancer. Oncogene 35(19):2485–2495. https://doi. org/10.1038/onc.2015.306
-
(2016)
Oncogene
, vol.35
, Issue.19
, pp. 2485-2495
-
-
Zhang, S.1
Chung, W.C.2
Xu, K.3
|