Notch-Jagged complex structure implicates a catch bond in tuning ligand sensitivity

Science

Volumn 355, Issue 6331, 2017, Pages 1320-1324

  Luca, Vincent C ^a,b   Kim, Byoung Choul ^b,c   Ge, Chenghao ^d   Kakuda, Shinako ^e   Wu, Di ^a,b   Roein Peikar, Mehdi ^b,c   Haltiwanger, Robert S ^e,g   Zhu, Cheng ^d,f   Ha, Taekjip ^b,c   Garcia, K Christopher ^a,b  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

^e STONY BROOK UNIVERSITY   (United States)

^f GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

^g UNIVERSITY OF GEORGIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; GLYCAN; GLYCOSYLTRANSFERASE; NOTCH RECEPTOR; PROTEIN JAGGED 1; FUCOSE; JAG1 PROTEIN, RAT; LIGAND; MEMBRANE PROTEIN; NOTCH1 PROTEIN, RAT; NOTCH1 RECEPTOR; PROTEIN; PROTEIN BINDING; SIGNAL PEPTIDE;

CELLS AND CELL COMPONENTS; CHEMICAL BINDING; CHEMICAL BONDING; CRYSTAL STRUCTURE; GROWTH; LIGAND; PROTEIN;

ARTICLE; CRYSTAL STRUCTURE; FLOW CYTOMETRY; FORCE; GENE MUTATION; HUMAN; HYDROGEN BOND; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; RECEPTOR SENSITIVITY; SIGNAL TRANSDUCTION; SURFACE PROPERTY; TENSION; ANIMAL; CHEMISTRY; GENETIC ENGINEERING; GENETICS; RAT; SACCHAROMYCES CEREVISIAE; ULTRASTRUCTURE; X RAY CRYSTALLOGRAPHY;

ANIMALS; CRYSTALLOGRAPHY, X-RAY; FUCOSE; GENETIC ENGINEERING; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; JAGGED-1 PROTEIN; LIGANDS; MEMBRANE PROTEINS; PROTEIN BINDING; PROTEIN DOMAINS; RATS; RECEPTOR, NOTCH1; SACCHAROMYCES CEREVISIAE; SIGNAL TRANSDUCTION;

EID: 85014437670     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aaf9739     Document Type: Article

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