Synthetic Human NOTCH1 EGF Modules Unraveled Molecular Mechanisms for the Structural and Functional Roles of Calcium Ions and O-Glycans in the Ligand-Binding Region

Biochemistry

Volumn 55, Issue 5, 2016, Pages 776-787

  Hayakawa, Shun ^a   Koide, Ryosuke ^a   Hinou, Hiroshi ^a,b   Nishimura, Shin Ichiro ^a,b  

^a HOKKAIDO UNIVERSITY   (Japan)

^b Hokkaido University and Medicinal Chemistry Pharmaceuticals LLC   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BINS; CELL CULTURE; CELLS; CYTOLOGY; DISEASES; ENZYME ACTIVITY; LIGANDS; NUCLEAR MAGNETIC RESONANCE; POLYSACCHARIDES; TISSUE HOMEOSTASIS;

GLYCOSYLATION SITES; HUMAN BREAST CANCER CELLS; MOLECULAR MECHANISM; MULTICELLULAR ORGANISMS; NOTCH SIGNALING PATHWAYS; NUCLEAR MAGNETIC RESONANCE STUDIES; NUCLEAR OVERHAUSER EFFECTS; TRANSMEMBRANE RECEPTORS;

CELL SIGNALING;

AMINO ACID; CALCIUM ION; EPIDERMAL GROWTH FACTOR; GLYCAN; NOTCH1 RECEPTOR; SUGAR; CALCIUM; LIGAND; NOTCH1 PROTEIN, HUMAN; POLYSACCHARIDE; PROTEIN BINDING;

A549 CELL LINE; ADENOCARCINOMA CELL LINE; ARTICLE; BETA SHEET; BREAST CANCER CELL LINE; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME MECHANISM; GLYCOSYLATION; HUMAN; HUMAN CELL; LIGAND BINDING; LUNG ADENOCARCINOMA; MCF 7 CELL LINE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEAR OVERHAUSER EFFECT; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN STABILITY; PROTEIN STRUCTURE; PROTEIN SYNTHESIS; STRUCTURE ACTIVITY RELATION; AMINO ACID SEQUENCE; CHEMISTRY; METABOLISM; MOLECULAR GENETICS; PROTEIN PROCESSING;

AMINO ACID SEQUENCE; CALCIUM; EPIDERMAL GROWTH FACTOR; GLYCOSYLATION; HUMANS; LIGANDS; MCF-7 CELLS; MOLECULAR SEQUENCE DATA; POLYSACCHARIDES; PROTEIN BINDING; PROTEIN FOLDING; PROTEIN PROCESSING, POST-TRANSLATIONAL; RECEPTOR, NOTCH1;

EID: 84957922453     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/acs.biochem.5b01284     Document Type: Article

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