Absence of post-translational aspartyl β-hydroxylation of epidermal growth factor domains in mice leads to developmental defects and an increased incidence of intestinal neoplasia

Journal of Biological Chemistry

Volumn 277, Issue 15, 2002, Pages 12970-12977

  Dinchuk, Joseph E ^a   Focht, Richard J ^a   Kelley, Jennifer A ^a   Henderson, Nancy L ^a   Zolotarjova, Nina I ^a   Wynn, Richard ^a   Neff, Nicola T ^a   Link, John ^a   Huber, Reid M ^a   Burn, Timothy C ^a   Rupar, Mark J ^a   Cunningham, Mark R ^a   Selling, Bernard H ^a   Ma, Jianhong ^a   Stern, Andrew A ^a   Hollis, Gregory F ^a   Stein, Robert B ^a   Friedman, Paul A ^a  

^a BRISTOL MYERS SQUIBB PHARMACEUTICAL RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROXYLATION; TISSUE; TUMORS;

LIGANDS;

PROTEINS;

ASPARTIC ACID; BLOOD CLOTTING FACTOR 10; EPIDERMAL GROWTH FACTOR; LIGAND; NOTCH RECEPTOR; OXYGENASE;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARCINOGENESIS; CONGENITAL MALFORMATION; CONTROLLED STUDY; ENZYME ACTIVITY; FACE DYSMORPHIA; GENE DISRUPTION; GLYCOSYLATION; HYDROXYLATION; INTESTINE CANCER; INTESTINE POLYP; KNOCKOUT MOUSE; LIVER; MODULATION; MOUSE; MULTIGENE FAMILY; NONHUMAN; PALATE MALFORMATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROCESSING; SIGNAL TRANSDUCTION; SUBFERTILITY; SYNDACTYLY; TUMOR MODEL; TUMOR VOLUME;

AMINO ACID SEQUENCE; ANIMALS; CATALYTIC DOMAIN; EPIDERMAL GROWTH FACTOR; EXONS; FEMALE; HYDROXYLATION; INCIDENCE; INTESTINAL NEOPLASMS; MALE; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; MIXED FUNCTION OXYGENASES; PROTEIN PROCESSING, POST-TRANSLATIONAL; RECEPTORS, NOTCH;

ANIMALIA;

EID: 0037066706     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M110389200     Document Type: Article

References (34)