Segmentation defects of Notch pathway mutants and absence of a synergistic phenotype in Lunatic fringe/radical fringe double mutant mice

Genesis (United States)

Volumn 33, Issue 1, 2002, Pages 21-28

  Zhang, Nian ^a   Norton, Christine R ^b   Gridley, Thomas ^b  

^a VAN ANDEL RESEARCH INSTITUTE   (United States)

^b JACKSON LABORATORY   (United States)

Author keywords

Fringe genes; Presomitic mesoderm; Radical fringe knockout mice; Segmentation clock; Somite formation

Indexed keywords

GENE PRODUCT; NOTCH RECEPTOR; PROTEIN DLL1; PROTEIN DLL3; PROTEIN LFNG; PROTEIN RFNG; UNCLASSIFIED DRUG;

ARTICLE; EMBRYO; EMBRYO SEGMENTATION; GENE EXPRESSION; GENE MUTATION; HOMOZYGOTE; MOUSE; MOUSE MUTANT; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; SKELETON MALFORMATION;

ANIMALIA; VERTEBRATA;

EID: 0036267319     PISSN: 1526954X     EISSN: None     Source Type: Journal    
DOI: 10.1002/gene.10081     Document Type: Article

References (52)

1. Dynamic expression of lunatic fringe suggests a link between notch signaling and an autonomous cellular oscillator driving somite segmentation
2. Interaction between Notch signalling and lunatic fringe during somite boundary formation in the mouse
3. Dynamic expression and essential functions of Hes7 in somite segmentation
4. Glycosyltransferase activity of Fringe modulates Notch-Delta interactions
5. Fringe modulation of Jagged1-induced Notch signaling requires the action of beta 4galactosyl-transferase-1
6. Fringe boundaries coincide with Notch-dependent patterning centres in mammals and alter Notch-dependent development in Drosophila
7. Notch1 is required for the coordinate segmentation of somites
8. Conservation of the Notch signalling pathway in mammalian neurogenesis
9. Mouse Dll3: A novel divergent Delta gene which may complement the function of other Delta homologues during early pattern formation in the mouse embryo
10. Lunatic fringe is an essential mediator of somite segmentation and patterning
11. Serrate-mediated activation of Notch is specifically blocked by the product of the gene fringe in the dorsal compartment of the Drosophila wing imaginal disc
12. Waves of mouse Lunatic fringe expression, in four-hour cycles at two-hour intervals, precede somite boundary formation
13. Somitogenesis
14. Fringe differentially modulates Jagged1 and Delta1 signalling through Notch1 and Notch2
15. Somite formation and patterning
16. Maintenance of somite borders in mice requires the Delta homologue Dll1
17. Control of her1 expression during zebrafish somitogenesis by a delta-dependent oscillator and an independent wave-front activity
18. Defects in limb, craniofacial and thymic development in Jagged2 mutant mice
19. Notch signalling and the synchronization of the somite segmentation clock
20. A family of mammalian Fringe genes implicated in boundary determination and the Notch pathway
21. Notch signalling is required for cyclic expression of the hairy-like gene HES1 in the presomitic mesoderm
22. The role of presenilin 1 during somite segmentation
23. Notch signaling is essential for vascular morphogenesis in mice
24. Delta3 is disrupted in the pudgy somite patterning mutant
25. Oscillating expression of c-Hey2 in the presomitic mesoderm suggests that the segmentation clock may use combinatorial signaling through multiple interacting bHLH factors
26. Homologues of c-hairy1 (her9) and lunatic fringe in zebrafish are expressed in the developing central nervous system, but not in the presomitic mesoderm
27. Paired-related murine homeobox gene expressed in the developing sclerotome, kidney, and nervous system
28. A molecular clock involved in somite segmentation
29. Defects in development of the kidney, heart and eye vasculature in mice homozygous for a hypomorphic Notch2 mutation
30. A mouse model of Alagille syndrome: Notch2 as a genetic modifier of Jag1 haploinsufficiency
31. The lunatic Fringe gene is a target of the molecular clock linked to somite segmentation in avian embryos
32. Mouse Serrate-1 (Jagged-1): Expression in the developing tooth is regulated by epithelial-mesenchymal interactions and fibroblast growth factor-4
33. Fringe is a glycosyltransferase that modifies Notch
34. Mammalian Notch1 is modified with two unusual forms of O-linked glycosylation found on epidermal growth factor-like modules
35. The notch signalling regulator fringe acts in the Golgi apparatus and requires the glycosyltransferase signature motif DXD
36. A mouse gene of the paired-related homeobox class expressed in the caudal somite compartment and in the developing vertebral column, kidney and nervous system
37. Disruption of the mouse RBP-J kappa gene results in early embryonic death
38. Avian hairy gene expression identifies a molecular clock linked to vertebrate segmentation and somitogenesis
39. Fringe modulates Notch-ligand interactions
40. The vertebrate segmentation clock
41. Zebrafish lunatic fringe demarcates segmental boundaries
42. Mesp2: A novel mouse gene expressed in the presegmented mesoderm and essential for segmentation initiation
43. Zebrafish Mesp family genes, mesp-a and mesp-b are segmentally expressed in the presomitic mesoderm, and Mesp-b confers the anterior identity to the developing somites
44. Manic fringe and lunatic fringe modify different sites of the Notch2 extracellular region, resulting in different signaling modulation
45. Perinatal lethality and defects in hindbrain development in mice homozygous for a targeted mutation of the zinc finger gene Krox20
46. Notch1 is essential for postimplantation development in mice
47. Mesp2 initiates somite segmentation through the Notch signalling pathway
48. Presenilin 1 is required for Notch1 and Dll1 expression in the paraxial mesoderm
49. Embryonic lethality and vascular defects in mice lacking the Notch ligand Jagged1
50. Defects in somite formation in Lunatic fringe deficient mice
51. A mutation in the Lunatic fringe gene suppresses the effects of a Jagged2 mutation on inner hair cell development in the cochlea