Chemical synthesis, folding, and structural insights into O-fucosylated epidermal growth factor-like repeat 12 of mouse notch-1 receptor

Journal of the American Chemical Society

Volumn 132, Issue 42, 2010, Pages 14857-14865

  Hiruma Shimizu, Kazumi ^a,b   Hosoguchi, Kensaku ^a   Liu, Yan ^c   Fujitani, Naoki ^a   Ohta, Takashi ^b   Hinou, Hiroshi ^a   Matsushita, Takahiko ^a,b   Shimizu, Hiroki ^b   Feizi, Ten ^c   Nishimura, Shin Ichiro ^a,b  

^a HOKKAIDO UNIVERSITY   (Japan)

^b NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY AIST   (Japan)

^c IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CELL SURFACES; CHEMICAL SYNTHESIS; CONFORMATIONAL CHANGE; DISULFIDE BONDS; EFFICIENT SYNTHESIS; ELONGATION PROCESS; EPIDERMAL GROWTH FACTOR-LIKE REPEAT; EPIDERMAL GROWTH FACTORS; EXTRACELLULAR DOMAINS; GLYCAN CHAINS; MAMMALIAN CELLS; METAZOA; METHYL GROUP; NOTCH RECEPTOR; O-FUCOSE; O-FUCOSYLATION; STRUCTURAL CHARACTERIZATION; STRUCTURAL INSIGHTS; STRUCTURAL STUDIES; TETRASACCHARIDES; TRIPEPTIDE;

CELL MEMBRANES; CONFORMATIONS; ENZYME ACTIVITY; FUNCTIONAL GROUPS; MAMMALS; PEPTIDES;

SYNTHESIS (CHEMICAL);

EPIDERMAL GROWTH FACTOR; FUCOSE; GLYCAN; GLYCOPEPTIDE; NOTCH1 RECEPTOR; TETRASACCHARIDE;

AMINO ACID SEQUENCE; ARTICLE; ENZYME ACTIVITY; FUCOSYLATION; GLYCOSYLATION; LIGAND BINDING; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN FOLDING; SIGNAL TRANSDUCTION; STRUCTURE ANALYSIS; SYNTHESIS;

AMINO ACID SEQUENCE; ANIMALS; CARBOHYDRATE SEQUENCE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FUCOSE; GLYCOSYLATION; MICE; MOLECULAR SEQUENCE DATA; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN CONFORMATION; PROTEIN FOLDING; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTOR, NOTCH1; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

EID: 77958492721     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja105216u     Document Type: Article

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