메뉴 건너뛰기




Volumn 25, Issue 11, 2018, Pages 1327-1339

Immune checkpoint inhibitors and cardiac toxicity: An emerging issue

Author keywords

Cancer; Cardiac toxicity; Checkpoints; CTLA 4; Melanoma; Myocarditis; PD 1; PD L1

Indexed keywords

ATEZOLIZUMAB; AVELUMAB; BMS 946559; BTLA ANTIBODY; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; DURVALUMAB; IMMUNE CHECKPOINT INHIBITOR; IMMUNOLOGICAL ANTINEOPLASTIC AGENT; IPILIMUMAB; LAG 3 ANTIBODY; NIVOLUMAB; PEMBROLIZUMAB; PROGRAMMED DEATH 1 LIGAND 1; TIGIT ANTIBODY; TIM 3 ANTIBODY; UNCLASSIFIED DRUG; VISTA ANTIBODY; ANTINEOPLASTIC AGENT; MONOCLONAL ANTIBODY; T LYMPHOCYTE RECEPTOR;

EID: 85047796335     PISSN: 09298673     EISSN: 1875533X     Source Type: Journal    
DOI: 10.2174/0929867324666170407125017     Document Type: Review
Times cited : (99)

References (114)
  • 1
    • 84992187004 scopus 로고    scopus 로고
    • 2016 ESC Position Paper on cancer treatments and cardiovascular toxicity developed under the auspices of the ESC Committee for Practice Guidelines: The Task Force for cancer treatments and cardiovascular toxicity of the European Society of Cardiology (ESC)
    • Authors/Task Force Members; ESC Committee for Practice Guidelines (CPG)
    • Zamorano, J.L.; Lancellotti, P.; Rodriguez Muñoz, D.; Aboyans, V.; Asteggiano, R.; Galderisi, M.; Habib, G.; Lenihan, D.J.; Lip, G.Y.; Lyon, A.R.; Lopez Fernandez, T.; Mohty, D.; Piepoli, M.F.; Tamargo, J.; Torbicki, A.; Suter, T.M. Authors/Task Force Members; ESC Committee for Practice Guidelines (CPG). 2016 ESC Position Paper on cancer treatments and cardiovascular toxicity developed under the auspices of the ESC Committee for Practice Guidelines: The Task Force for cancer treatments and cardiovascular toxicity of the European Society of Cardiology (ESC). Eur. Heart J., 2016, 37(36), 2768-2801.
    • (2016) Eur. Heart J , vol.37 , Issue.36 , pp. 2768-2801
    • Zamorano, J.L.1    Lancellotti, P.2    Rodriguez Muñoz, D.3    Aboyans, V.4    Asteggiano, R.5    Galderisi, M.6    Habib, G.7    Lenihan, D.J.8    Lip, G.Y.9    Lyon, A.R.10    Lopez Fernandez, T.11    Mohty, D.12    Piepoli, M.F.13    Tamargo, J.14    Torbicki, A.15    Suter, T.M.16
  • 2
    • 84883592712 scopus 로고    scopus 로고
    • Emerging paradigms in cardiomyopathies associated with cancer therapies
    • Ky, B.; Vejpongsa, P.; Yeh, E.T.; Force, T.; Moslehi, J.J. Emerging paradigms in cardiomyopathies associated with cancer therapies. Circ. Res., 2013, 113(6), 754-764.
    • (2013) Circ. Res , vol.113 , Issue.6 , pp. 754-764
    • Ky, B.1    Vejpongsa, P.2    Yeh, E.T.3    Force, T.4    Moslehi, J.J.5
  • 4
    • 84991219713 scopus 로고    scopus 로고
    • Cardiovascular Toxic Effects of Targeted Cancer Therapies
    • Moslehi, J.J. Cardiovascular Toxic Effects of Targeted Cancer Therapies. N. Engl. J. Med., 2016, 375(15), 1457-1467.
    • (2016) N. Engl. J. Med , vol.375 , Issue.15 , pp. 1457-1467
    • Moslehi, J.J.1
  • 5
    • 84876526107 scopus 로고    scopus 로고
    • Cancer drugs and the heart: Importance and management
    • Suter, T.M.; Ewer, M.S. Cancer drugs and the heart: importance and management. Eur. Heart J., 2013, 34(15), 1102-1111.
    • (2013) Eur. Heart J , vol.34 , Issue.15 , pp. 1102-1111
    • Suter, T.M.1    Ewer, M.S.2
  • 7
    • 85007452454 scopus 로고    scopus 로고
    • Cancer immunotherapy innovator James Allison receives the 2015 Lasker~DeBakey Clinical Medical Research Award
    • Hurst, J.H. Cancer immunotherapy innovator James Allison receives the 2015 Lasker~DeBakey Clinical Medical Research Award. J. Clin. Invest., 2015, 125(10), 3732-3736.
    • (2015) J. Clin. Invest , vol.125 , Issue.10 , pp. 3732-3736
    • Hurst, J.H.1
  • 19
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan, D.; Weinberg, R.A. Hallmarks of cancer: The next generation. Cell, 2011, 144(5), 646-674.
    • (2011) Cell , vol.144 , Issue.5 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 20
    • 84928771999 scopus 로고    scopus 로고
    • T cell exclusion, immune privilege, and the tumor microenvironment
    • Joyce, J.A.; Fearon, D.T. T cell exclusion, immune privilege, and the tumor microenvironment. Science, 2015, 348(6230), 74-80.
    • (2015) Science , vol.348 , Issue.6230 , pp. 74-80
    • Joyce, J.A.1    Fearon, D.T.2
  • 21
    • 79953151458 scopus 로고    scopus 로고
    • Cancer immunoediting: Integrating immunitys roles in cancer suppression and promotion
    • Schreiber, R.D.; Old, L.J.; Smyth, M.J. Cancer immunoediting: integrating immunitys roles in cancer suppression and promotion. Science, 2011, 331(6024), 1565-1570.
    • (2011) Science , vol.331 , Issue.6024 , pp. 1565-1570
    • Schreiber, R.D.1    Old, L.J.2    Smyth, M.J.3
  • 22
    • 84925545111 scopus 로고    scopus 로고
    • Clinical blockade of PD1 and LAG3potential mechanisms of action
    • Nguyen, L.T.; Ohashi, P.S. Clinical blockade of PD1 and LAG3potential mechanisms of action. Nat. Rev. Immunol., 2015, 15(1), 45-56.
    • (2015) Nat. Rev. Immunol , vol.15 , Issue.1 , pp. 45-56
    • Nguyen, L.T.1    Ohashi, P.S.2
  • 23
    • 84928774156 scopus 로고    scopus 로고
    • The future of immune checkpoint therapy
    • Sharma, P.; Allison, J.P. The future of immune checkpoint therapy. Science, 2015, 348(6230), 56-61.
    • (2015) Science , vol.348 , Issue.6230 , pp. 56-61
    • Sharma, P.1    Allison, J.P.2
  • 24
    • 84941280057 scopus 로고    scopus 로고
    • Beyond CTLA-4 and PD-1, the Generation Z of Negative Checkpoint Regulators
    • Le Mercier, I.; Lines, J.L.; Noelle, R.J. Beyond CTLA-4 and PD-1, the Generation Z of Negative Checkpoint Regulators. Front. Immunol., 2015, 6, 418.
    • (2015) Front. Immunol , vol.6 , pp. 418
    • Le Mercier, I.1    Lines, J.L.2    Noelle, R.J.3
  • 25
    • 84941711371 scopus 로고    scopus 로고
    • Anti-PD-1/PD-L1 therapy of human cancer: Past, present, and future
    • Chen, L.; Han, X. Anti-PD-1/PD-L1 therapy of human cancer: past, present, and future. J. Clin. Invest., 2015, 125(9), 3384-3391.
    • (2015) J. Clin. Invest , vol.125 , Issue.9 , pp. 3384-3391
    • Chen, L.1    Han, X.2
  • 26
    • 84994120928 scopus 로고    scopus 로고
    • PD-1-PD-L1 immune-checkpoint blockade in B-cell lymphomas. Nat
    • Goodman, A.; Patel, S.P.; Kurzrock, R. PD-1-PD-L1 immune-checkpoint blockade in B-cell lymphomas. Nat. Rev. Clin. Oncol., 2017, 14(4), 203-220.
    • (2017) Rev. Clin. Oncol , vol.14 , Issue.4 , pp. 203-220
    • Goodman, A.1    Patel, S.P.2    Kurzrock, R.3
  • 29
    • 0022632220 scopus 로고
    • A 44 kilodalton cell surface homodimer regulates interleukin 2 production by activated human T lymphocytes
    • Martin, P.J.; Ledbetter, J.A.; Morishita, Y.; June, C.H.; Beatty, P.G.; Hansen, J.A. A 44 kilodalton cell surface homodimer regulates interleukin 2 production by activated human T lymphocytes. J. Immunol., 1986, 136(9), 3282-3287.
    • (1986) J. Immunol , vol.136 , Issue.9 , pp. 3282-3287
    • Martin, P.J.1    Ledbetter, J.A.2    Morishita, Y.3    June, C.H.4    Beatty, P.G.5    Hansen, J.A.6
  • 30
    • 0027761138 scopus 로고
    • Identification of an alternative CTLA-4 ligand costimulatory for T cell activation
    • Hathcock, K.S.; Laszlo, G.; Dickler, H.B.; Bradshaw, J.; Linsley, P.; Hodes, R.J. Identification of an alternative CTLA-4 ligand costimulatory for T cell activation. Science, 1993, 262(5135), 905-907.
    • (1993) Science , vol.262 , Issue.5135 , pp. 905-907
    • Hathcock, K.S.1    Laszlo, G.2    Dickler, H.B.3    Bradshaw, J.4    Linsley, P.5    Hodes, R.J.6
  • 33
    • 0025322552 scopus 로고
    • T-cell antigen CD28 mediates adhesion with B cells by interacting with activation antigen B7/BB-1
    • Linsley, P.S.; Clark, E.A.; Ledbetter, J.A. T-cell antigen CD28 mediates adhesion with B cells by interacting with activation antigen B7/BB-1. Proc. Natl. Acad. Sci. USA, 1990, 87(13), 5031-5035.
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , Issue.13 , pp. 5031-5035
    • Linsley, P.S.1    Clark, E.A.2    Ledbetter, J.A.3
  • 34
    • 0028867420 scopus 로고
    • Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4
    • Tivol, E.A.; Borriello, F.; Schweitzer, A.N.; Lynch, W.P.; Bluestone, J.A.; Sharpe, A.H. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4. Immunity, 1995, 3(5), 541-547.
    • (1995) Immunity , vol.3 , Issue.5 , pp. 541-547
    • Tivol, E.A.1    Borriello, F.2    Schweitzer, A.N.3    Lynch, W.P.4    Bluestone, J.A.5    Sharpe, A.H.6
  • 37
    • 68149155982 scopus 로고    scopus 로고
    • Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor activity of anti-CTLA-4 antibodies
    • Peggs, K.S.; Quezada, S.A.; Chambers, C.A.; Korman, A.J.; Allison, J.P. Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor activity of anti-CTLA-4 antibodies. J. Exp. Med., 2009, 206(8), 1717-1725.
    • (2009) J. Exp. Med , vol.206 , Issue.8 , pp. 1717-1725
    • Peggs, K.S.1    Quezada, S.A.2    Chambers, C.A.3    Korman, A.J.4    Allison, J.P.5
  • 38
    • 0029947568 scopus 로고    scopus 로고
    • Enhancement of antitumor immunity by CTLA-4 blockade
    • Leach, D.R.; Krummel, M.F.; Allison, J.P. Enhancement of antitumor immunity by CTLA-4 blockade. Science, 1996, 271(5256), 1734-1736.
    • (1996) Science , vol.271 , Issue.5256 , pp. 1734-1736
    • Leach, D.R.1    Krummel, M.F.2    Allison, J.P.3
  • 39
    • 0033180181 scopus 로고    scopus 로고
    • Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor
    • Nishimura, H.; Nose, M.; Hiai, H.; Minato, N.; Honjo, T. Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor. Immunity, 1999, 11(2), 141-151.
    • (1999) Immunity , vol.11 , Issue.2 , pp. 141-151
    • Nishimura, H.1    Nose, M.2    Hiai, H.3    Minato, N.4    Honjo, T.5
  • 41
    • 84994104553 scopus 로고    scopus 로고
    • Molecular and Biochemical Aspects of the PD-1 Checkpoint Pathway
    • Boussiotis, V.A. Molecular and Biochemical Aspects of the PD-1 Checkpoint Pathway. N. Engl. J. Med., 2016, 375(18), 1767-1778.
    • (2016) N. Engl. J. Med , vol.375 , Issue.18 , pp. 1767-1778
    • Boussiotis, V.A.1
  • 42
    • 34547794178 scopus 로고    scopus 로고
    • PD-1 and PD-1 ligands: From discovery to clinical application
    • Okazaki, T.; Honjo, T. PD-1 and PD-1 ligands: from discovery to clinical application. Int. Immunol., 2007, 19(7), 813-824.
    • (2007) Int. Immunol , vol.19 , Issue.7 , pp. 813-824
    • Okazaki, T.1    Honjo, T.2
  • 43
    • 84930615422 scopus 로고    scopus 로고
    • Upregulation of Programmed Death-1 and Its Ligand in Cardiac Injury Models: Interaction with GADD153
    • Baban, B.; Liu, J.Y.; Qin, X.; Weintraub, N.L.; Mozaffari, M.S. Upregulation of Programmed Death-1 and Its Ligand in Cardiac Injury Models: Interaction with GADD153. PLoS One, 2015, 10(4), e0124059.
    • (2015) Plos One , vol.10 , Issue.4
    • Baban, B.1    Liu, J.Y.2    Qin, X.3    Weintraub, N.L.4    Mozaffari, M.S.5
  • 45
    • 84864324543 scopus 로고    scopus 로고
    • Programmed cell death 1 forms negative costimulatory microclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2
    • Yokosuka, T.; Takamatsu, M.; Kobayashi-Imanishi, W.; Hashimoto-Tane, A.; Azuma, M.; Saito, T. Programmed cell death 1 forms negative costimulatory microclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2. J. Exp. Med., 2012, 209(6), 1201-1217.
    • (2012) J. Exp. Med , vol.209 , Issue.6 , pp. 1201-1217
    • Yokosuka, T.1    Takamatsu, M.2    Kobayashi-Imanishi, W.3    Hashimoto-Tane, A.4    Azuma, M.5    Saito, T.6
  • 48
    • 77953747963 scopus 로고    scopus 로고
    • The PD-1 pathway in tolerance and autoimmunity
    • Francisco, L.M.; Sage, P.T.; Sharpe, A.H. The PD-1 pathway in tolerance and autoimmunity. Immunol. Rev., 2010, 236, 219-242.
    • (2010) Immunol. Rev , vol.236 , pp. 219-242
    • Francisco, L.M.1    Sage, P.T.2    Sharpe, A.H.3
  • 50
    • 0029117828 scopus 로고
    • Tumor necrosis factor soluble receptors in patients with various degrees of congestive heart failure
    • Ferrari, R.; Bachetti, T.; Confortini, R.; Opasich, C.; Febo, O.; Corti, A.; Cassani, G.; Visioli, O. Tumor necrosis factor soluble receptors in patients with various degrees of congestive heart failure. Circulation, 1995, 92(6), 1479-1486.
    • (1995) Circulation , vol.92 , Issue.6 , pp. 1479-1486
    • Ferrari, R.1    Bachetti, T.2    Confortini, R.3    Opasich, C.4    Febo, O.5    Corti, A.6    Cassani, G.7    Visioli, O.8
  • 53
    • 0037126021 scopus 로고    scopus 로고
    • Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade
    • Iwai, Y.; Ishida, M.; Tanaka, Y.; Okazaki, T.; Honjo, T.; Minato, N. Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade. Proc. Natl. Acad. Sci. USA, 2002, 99(19), 12293-12297.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , Issue.19 , pp. 12293-12297
    • Iwai, Y.1    Ishida, M.2    Tanaka, Y.3    Okazaki, T.4    Honjo, T.5    Minato, N.6
  • 54
    • 43549115533 scopus 로고    scopus 로고
    • B7-H1 is a ubiquitous antiapoptotic receptor on cancer cells
    • Azuma, T.; Yao, S.; Zhu, G.; Flies, A.S.; Flies, S.J.; Chen, L. B7-H1 is a ubiquitous antiapoptotic receptor on cancer cells. Blood, 2008, 111(7), 3635-3643.
    • (2008) Blood , vol.111 , Issue.7 , pp. 3635-3643
    • Azuma, T.1    Yao, S.2    Zhu, G.3    Flies, A.S.4    Flies, S.J.5    Chen, L.6
  • 55
    • 84959865627 scopus 로고    scopus 로고
    • Regulation of PD-L1: A novel role of pro-survival signalling in cancer
    • Chen, J.; Jiang, C.C.; Jin, L.; Zhang, X.D. Regulation of PD-L1: a novel role of pro-survival signalling in cancer. Ann. Oncol., 2016, 27(3), 409-416.
    • (2016) Ann. Oncol , vol.27 , Issue.3 , pp. 409-416
    • Chen, J.1    Jiang, C.C.2    Jin, L.3    Zhang, X.D.4
  • 56
    • 44349150012 scopus 로고    scopus 로고
    • Inhibitory B7-family molecules in the tumour microenvironment
    • Zou, W.; Chen, L. Inhibitory B7-family molecules in the tumour microenvironment. Nat. Rev. Immunol., 2008, 8(6), 467-477.
    • (2008) Nat. Rev. Immunol , vol.8 , Issue.6 , pp. 467-477
    • Zou, W.1    Chen, L.2
  • 67
    • 84874635440 scopus 로고    scopus 로고
    • Tim-3 expression defines regulatory T cells in human tumors
    • Yan, J.; Zhang, Y.; Zhang, J.P.; Liang, J.; Li, L.; Zheng, L. Tim-3 expression defines regulatory T cells in human tumors. PLoS One, 2013, 8(3), e58006.
    • (2013) Plos One , vol.8 , Issue.3
    • Yan, J.1    Zhang, Y.2    Zhang, J.P.3    Liang, J.4    Li, L.5    Zheng, L.6
  • 77
    • 2442477456 scopus 로고    scopus 로고
    • An inhibitory Ig superfamily protein expressed by lymphocytes and APCs is also an early marker of thymocyte positive selection
    • Han, P.; Goularte, O.D.; Rufner, K.; Wilkinson, B.; Kaye, J. An inhibitory Ig superfamily protein expressed by lymphocytes and APCs is also an early marker of thymocyte positive selection. J. Immunol., 2004, 172(10), 5931-5939.
    • (2004) J. Immunol , vol.172 , Issue.10 , pp. 5931-5939
    • Han, P.1    Goularte, O.D.2    Rufner, K.3    Wilkinson, B.4    Kaye, J.5
  • 81
    • 84895904745 scopus 로고    scopus 로고
    • Mitigating the toxic effects of anticancer immunotherapy
    • Gangadhar, T.C.; Vonderheide, R.H. Mitigating the toxic effects of anticancer immunotherapy. Nat. Rev. Clin. Oncol., 2014, 11(2), 91-99.
    • (2014) Nat. Rev. Clin. Oncol , vol.11 , Issue.2 , pp. 91-99
    • Gangadhar, T.C.1    Vonderheide, R.H.2
  • 83
    • 84957839638 scopus 로고    scopus 로고
    • CTLA-4 and PD-1 Pathways: Similarities, Differences, and Implications of Their Inhibition
    • Buchbinder, E.I.; Desai, A. CTLA-4 and PD-1 Pathways: Similarities, Differences, and Implications of Their Inhibition. Am. J. Clin. Oncol., 2016, 39(1), 98-106.
    • (2016) Am. J. Clin. Oncol , vol.39 , Issue.1 , pp. 98-106
    • Buchbinder, E.I.1    Desai, A.2
  • 87
    • 84864052441 scopus 로고    scopus 로고
    • Management of immune-related adverse events and kinetics of response with ipilimumab
    • Weber, J.S.; Kähler, K.C.; Hauschild, A. Management of immune-related adverse events and kinetics of response with ipilimumab. J. Clin. Oncol., 2012, 30(21), 2691-2697.
    • (2012) J. Clin. Oncol , vol.30 , Issue.21 , pp. 2691-2697
    • Weber, J.S.1    Kähler, K.C.2    Hauschild, A.3
  • 96
    • 34548359396 scopus 로고    scopus 로고
    • CTLA-4 ablation and interleukin-12 driven differentiation synergistically augment cardiac pathogenicity of cytotoxic T lymphocytes
    • Love, V.A.; Grabie, N.; Duramad, P.; Stavrakis, G.; Sharpe, A.; Lichtman, A. CTLA-4 ablation and interleukin-12 driven differentiation synergistically augment cardiac pathogenicity of cytotoxic T lymphocytes. Circ. Res., 2007, 101(3), 248-257.
    • (2007) Circ. Res , vol.101 , Issue.3 , pp. 248-257
    • Love, V.A.1    Grabie, N.2    Duramad, P.3    Stavrakis, G.4    Sharpe, A.5    Lichtman, A.6
  • 98
    • 84997637224 scopus 로고    scopus 로고
    • Acute heart failure due to autoimmune myocarditis under pembrolizumab treatment for metastatic melanoma
    • Läubli, H.; Balmelli, C.; Bossard, M.; Pfister, O.; Glatz, K.; Zippelius, A. Acute heart failure due to autoimmune myocarditis under pembrolizumab treatment for metastatic melanoma. J. Immunother. Cancer, 2015, 3, 11.
    • (2015) J. Immunother. Cancer , vol.3 , pp. 11
    • Läubli, H.1    Balmelli, C.2    Bossard, M.3    Pfister, O.4    Glatz, K.5    Zippelius, A.6
  • 99
    • 84977156516 scopus 로고    scopus 로고
    • Apical ballooning and cardiomyopathy in a melanoma patient treated with ipilimumab: A case of takotsubo-like syndrome
    • Geisler, B.P.; Raad, R.A.; Esaian, D.; Sharon, E.; Schwartz, D.R. Apical ballooning and cardiomyopathy in a melanoma patient treated with ipilimumab: a case of takotsubo-like syndrome. J. Immunother. Cancer, 2015, 3, 4.
    • (2015) J. Immunother. Cancer , vol.3 , pp. 4
    • Geisler, B.P.1    Raad, R.A.2    Esaian, D.3    Sharon, E.4    Schwartz, D.R.5
  • 100
    • 84980509873 scopus 로고    scopus 로고
    • Late onset ipilimumab-induced pericarditis and pericardial effusion: A rare but life threatening complication
    • Yun, S.; Vincelette, N. D.; Mansour, I.; Hariri, D.; Motamed, S. Late onset ipilimumab-induced pericarditis and pericardial effusion: a rare but life threatening complication. Case. Rep. Oncol. Med., 2015, 2015, 794842.
    • (2015) Case. Rep. Oncol. Med , vol.2015
    • Yun, S.1    Vincelette, N.D.2    Mansour, I.3    Hariri, D.4    Motamed, S.5
  • 105
    • 85010960752 scopus 로고    scopus 로고
    • Myocarditis with Immune Checkpoint Blockade
    • Caio, G. Myocarditis with Immune Checkpoint Blockade. N. Engl. J. Med., 2017, 376(3), 291-292.
    • (2017) N. Engl. J. Med , vol.376 , Issue.3 , pp. 291-292
    • Caio, G.1
  • 108
    • 84861109547 scopus 로고    scopus 로고
    • PD-1 protects against inflammation and myocyte damage in T cell-mediated myocarditis
    • Tarrio, M.L.; Grabie, N.; Bu, D.X.; Sharpe, A.H.; Lichtman, A.H. PD-1 protects against inflammation and myocyte damage in T cell-mediated myocarditis. J. Immunol., 2012, 188(10), 4876-4884.
    • (2012) J. Immunol , vol.188 , Issue.10 , pp. 4876-4884
    • Tarrio, M.L.1    Grabie, N.2    Bu, D.X.3    Sharpe, A.H.4    Lichtman, A.H.5
  • 109
    • 53149113444 scopus 로고    scopus 로고
    • Programmed death ligand 1 regulates a critical checkpoint for autoimmune myocarditis and pneumonitis in MRL mice
    • Lucas, J.A.; Menke, J.; Rabacal, W.A.; Schoen, F.J.; Sharpe, A.H.; Kelley, V.R. Programmed death ligand 1 regulates a critical checkpoint for autoimmune myocarditis and pneumonitis in MRL mice. J. Immunol., 2008, 181(4), 2513-2521.
    • (2008) J. Immunol , vol.181 , Issue.4 , pp. 2513-2521
    • Lucas, J.A.1    Menke, J.2    Rabacal, W.A.3    Schoen, F.J.4    Sharpe, A.H.5    Kelley, V.R.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.