Molecular mechanism of influenza A NS1-mediated TRIM25 recognition and inhibition

Nature Communications

Volumn 9, Issue 1, 2018, Pages

  Koliopoulos, Marios G ^a   Lethier, Mathilde ^b   Van Der Veen, Annemarthe G ^a   Haubrich, Kevin ^c   Hennig, Janosch ^c   Kowalinski, Eva ^b   Stevens, Rebecca V ^a   Martin, Stephen R ^a   Reis E Sousa, Caetano ^a   Cusack, Stephen ^b   Rittinger, Katrin ^a  

^a THE FRANCIS CRICK INSTITUTE   (United Kingdom)

^b EUROPEAN MOLECULAR BIOLOGY LABORATORY   (France)

^c EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DIMER; HOMODIMER; MONOMER; NONSTRUCTURAL PROTEIN 1; TRIM25 PROTEIN; UNCLASSIFIED DRUG; DDX58 PROTEIN, HUMAN; INS1 PROTEIN, INFLUENZA VIRUS; INTERFERON; PROTEIN BINDING; RETINOIC ACID INDUCIBLE PROTEIN I; TRANSCRIPTION FACTOR; TRIM25 PROTEIN, HUMAN; TRIPARTITE MOTIF PROTEIN; UBIQUITIN PROTEIN LIGASE; VIRAL PROTEIN; VIRUS RNA;

GENE; HOST; IMMUNE RESPONSE; INFLUENZA; INHIBITION; MOLECULAR ANALYSIS; PROTEIN; RNA; SUBSTRATE; VIRUS;

ARTICLE; BINDING SITE; CATALYSIS; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DIMERIZATION; INFLUENZA A; MUTATIONAL ANALYSIS; NONHUMAN; OLIGOMERIZATION; PROTEIN BINDING; PROTEIN STRUCTURE; PRY-SPRY DOMAIN; RING FINGER MOTIF; SIGNAL TRANSDUCTION; SURFACE AREA; UBIQUITINATION; AMINO ACID SEQUENCE; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; CELL CULTURE; CHEMISTRY; HEK293 CELL LINE; HUMAN; IMMUNOLOGY; PROTEIN DOMAIN; PROTEIN MULTIMERIZATION;

INFLUENZA A VIRUS;

AMINO ACID SEQUENCE; CELLS, CULTURED; DEAD BOX PROTEIN 58; HEK293 CELLS; HUMANS; INTERFERONS; PROTEIN BINDING; PROTEIN DOMAINS; PROTEIN MULTIMERIZATION; RNA, VIRAL; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; TRIPARTITE MOTIF PROTEINS; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION; VIRAL NONSTRUCTURAL PROTEINS;

EID: 85046850124     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/s41467-018-04214-8     Document Type: Article

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