MAGE-RING protein complexes comprise a family of E3 ubiquitin ligases

Molecular Cell

Volumn 39, Issue 6, 2010, Pages 963-974

  Doyle, Jennifer M ^a   Gao, Jinlan ^b   Wang, Jiawei ^b   Yang, Maojun ^b   Potts, Patrick Ryan ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b TSINGHUA UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

MELANOMA ANTIGEN; PROTEIN P53; RING FINGER PROTEIN; UBIQUITIN PROTEIN LIGASE E3;

ARTICLE; BIOCHEMISTRY; CELL ASSAY; CELL FUNCTION; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVITY; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN STRUCTURE; SENSITIVITY AND SPECIFICITY;

ANTIGENS, NEOPLASM; BIOCATALYSIS; CARRIER PROTEINS; CELL LINE; CELL LINE, TUMOR; CELL NUCLEUS; CRYSTALLOGRAPHY, X-RAY; CYTOPLASM; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MELANOMA-SPECIFIC ANTIGENS; MODELS, MOLECULAR; NEOPLASM PROTEINS; PROTEIN BINDING; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN STRUCTURE, QUATERNARY; RECOMBINANT PROTEINS; REPRESSOR PROTEINS; RING FINGER DOMAINS; TRANSFECTION; TUMOR SUPPRESSOR PROTEIN P53; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

EID: 77956936946     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molcel.2010.08.029     Document Type: Article

References (42)

1. Allton K., Jain A.K., Herz H.M., Tsai W.W., Jung S.Y., Qin J., Bergmann A., Johnson R.L., Barton M.C. Trim24 targets endogenous p53 for degradation. Proc. Natl. Acad. Sci. USA 2009, 106:11612-11616.
2. Barker P.A., Salehi A. The MAGE proteins: emerging roles in cell cycle progression, apoptosis, and neurogenetic disease. J. Neurosci. Res. 2002, 67:705-712.
3. Bolli M., Kocher T., Adamina M., Guller U., Dalquen P., Haas P., Mirlacher M., Gambazzi F., Harder F., Heberer M., et al. Tissue microarray evaluation of Melanoma antigen E (MAGE) tumor-associated antigen expression: potential indications for specific immunotherapy and prognostic relevance in squamous cell lung carcinoma. Ann. Surg. 2002, 236:785-793. discussion 793.
4. Borden K.L. RING domains: master builders of molecular scaffolds?. J. Mol. Biol. 2000, 295:1103-1112.
5. Brasseur F., Rimoldi D., Liénard D., Lethé B., Carrel S., Arienti F., Suter L., Vanwijck R., Bourlond A., Humblet Y., et al. Expression of MAGE genes in primary and metastatic cutaneous melanoma. Int. J. Cancer 1995, 63:375-380.
6. Brichard V.G., Lejeune D. GSK's antigen-specific cancer immunotherapy programme: pilot results leading to Phase III clinical development. Vaccine 2007, 25(Suppl 2):B61-B71.
7. Chomez P., De Backer O., Bertrand M., De Plaen E., Boon T., Lucas S. An overview of the MAGE gene family with the identification of all human members of the family. Cancer Res. 2001, 61:5544-5551.
8. Cilensek Z.M., Yehiely F., Kular R.K., Deiss L.P. A member of the GAGE family of tumor antigens is an anti-apoptotic gene that confers resistance to Fas/CD95/APO-1, Interferon-gamma, taxol and gamma-irradiation. Cancer Biol. Ther. 2002, 1:380-387.
9. De Smet C., Courtois S.J., Faraoni I., Lurquin C., Szikora J.P., De Backer O., Boon T. Involvement of two Ets binding sites in the transcriptional activation of the MAGE1 gene. Immunogenetics 1995, 42:282-290.
10. De Smet C., Lurquin C., Lethé B., Martelange V., Boon T. DNA methylation is the primary silencing mechanism for a set of germ line- and tumor-specific genes with a CpG-rich promoter. Mol. Cell. Biol. 1999, 19:7327-7335.
11. Dhodapkar M.V., Osman K., Teruya-Feldstein J., Filippa D., Hedvat C.V., Iversen K., Kolb D., Geller M.D., Hassoun H., Kewalramani T., et al. Expression of cancer/testis (CT) antigens MAGE-A1, MAGE-A3, MAGE-A4, CT-7, and NY-ESO-1 in malignant gammopathies is heterogeneous and correlates with site, stage and risk status of disease. Cancer Immun. 2003, 3:9.
12. Duan Z., Duan Y., Lamendola D.E., Yusuf R.Z., Naeem R., Penson R.T., Seiden M.V. Overexpression of MAGE/GAGE genes in paclitaxel/doxorubicin-resistant human cancer cell lines. Clin. Cancer Res. 2003, 9:2778-2785.
13. Flørenes V.A., Oyjord T., Holm R., Skrede M., Børresen A.L., Nesland J.M., Fodstad O. TP53 allele loss, mutations and expression in malignant melanoma. Br. J. Cancer 1994, 69:253-259.
14. Gérard M., Hernandez L., Wevrick R., Stewart C.L. Disruption of the mouse necdin gene results in early post-natal lethality. Nat. Genet. 1999, 23:199-202.
15. Goldman B., DeFrancesco L. The cancer vaccine roller coaster. Nat. Biotechnol. 2009, 27:129-139.
16. Jay P., Rougeulle C., Massacrier A., Moncla A., Mattei M.G., Malzac P., Roëckel N., Taviaux S., Lefranc J.L., Cau P., et al. The human necdin gene, NDN, is maternally imprinted and located in the Prader-Willi syndrome chromosomal region. Nat. Genet. 1997, 17:357-361.
17. Jungbluth A.A., Stockert E., Chen Y.T., Kolb D., Iversen K., Coplan K., Williamson B., Altorki N., Busam K.J., Old L.J. Monoclonal antibody MA454 reveals a heterogeneous expression pattern of MAGE-1 antigen in formalin-fixed paraffin embedded lung tumours. Br. J. Cancer 2000, 83:493-497.
18. Kozlov S.V., Bogenpohl J.W., Howell M.P., Wevrick R., Panda S., Hogenesch J.B., Muglia L.J., Van Gelder R.N., Herzog E.D., Stewart C.L. The imprinted gene Magel2 regulates normal circadian output. Nat. Genet. 2007, 39:1266-1272.
19. Liu W., Cheng S., Asa S.L., Ezzat S. The melanoma-associated antigen A3 mediates fibronectin-controlled cancer progression and metastasis. Cancer Res. 2008, 68:8104-8112.
20. López-Sánchez N., González-Fernández Z., Niinobe M., Yoshikawa K., Frade J.M. Single mage gene in the chicken genome encodes CMage, a protein with functional similarities to mammalian type II Mage proteins. Physiol. Genomics 2007, 30:156-171.
21. Lorick K.L., Jensen J.P., Fang S., Ong A.M., Hatakeyama S., Weissman A.M. RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination. Proc. Natl. Acad. Sci. USA 1999, 96:11364-11369.
22. Mishra L., Tully R.E., Monga S.P., Yu P., Cai T., Makalowski W., Mezey E., Pavan W.J., Mishra B. Praja1, a novel gene encoding a RING-H2 motif in mouse development. Oncogene 1997, 15:2361-2368.
23. Ohman Forslund K., Nordqvist K. The melanoma antigen genes-any clues to their functions in normal tissues?. Exp. Cell Res. 2001, 265:185-194.
24. Okamoto K., Kitabayashi I., Taya Y. KAP1 dictates p53 response induced by chemotherapeutic agents via Mdm2 interaction. Biochem. Biophys. Res. Commun. 2006, 351:216-222.
25. Ozato K., Shin D.M., Chang T.H., Morse H.C. TRIM family proteins and their emerging roles in innate immunity. Nat. Rev. Immunol. 2008, 8:849-860.
26. Park J.H., Kong G.H., Lee S.W. hMAGE-A1 overexpression reduces TNF-alpha cytotoxicity in ME-180 cells. Mol. Cells 2002, 14:122-129.
27. Patard J.J., Brasseur F., Gil-Diez S., Radvanyi F., Marchand M., François P., Abi-Aad A., Van Cangh P., Abbou C.C., Chopin D., et al. Expression of MAGE genes in transitional-cell carcinomas of the urinary bladder. Int. J. Cancer 1995, 64:60-64.
28. Pebernard S., McDonald W.H., Pavlova Y., Yates J.R., Boddy M.N. Nse1, Nse2, and a novel subunit of the Smc5-Smc6 complex, Nse3, play a crucial role in meiosis. Mol. Biol. Cell 2004, 15:4866-4876.
29. Pebernard S., Perry J.J., Tainer J.A., Boddy M.N. Nse1 RING-like domain supports functions of the Smc5-Smc6 holocomplex in genome stability. Mol. Biol. Cell 2008, 19:4099-4109.
30. Potts P.R. The Yin and Yang of the MMS21-SMC5/6 SUMO ligase complex in homologous recombination. DNA Repair (Amst.) 2009, 8:499-506.
31. Potts P.R., Porteus M.H., Yu H. Human SMC5/6 complex promotes sister chromatid homologous recombination by recruiting the SMC1/3 cohesin complex to double-strand breaks. EMBO J. 2006, 25:3377-3388.
32. Potts P.R., Yu H. Human MMS21/NSE2 is a SUMO ligase required for DNA repair. Mol. Cell. Biol. 2005, 25:7021-7032.
33. Potts P.R., Yu H. The SMC5/6 complex maintains telomere length in ALT cancer cells through SUMOylation of telomere-binding proteins. Nat. Struct. Mol. Biol. 2007, 14:581-590.
34. Scanlan M.J., Gure A.O., Jungbluth A.A., Old L.J., Chen Y.T. Cancer/testis antigens: an expanding family of targets for cancer immunotherapy. Immunol. Rev. 2002, 188:22-32.
35. Scanlan M.J., Simpson A.J., Old L.J. The cancer/testis genes: review, standardization, and commentary. Cancer Immun. 2004, 4:1.
36. Simpson A.J., Caballero O.L., Jungbluth A., Chen Y.T., Old L.J. Cancer/testis antigens, gametogenesis and cancer. Nat. Rev. Cancer 2005, 5:615-625.
37. van der Bruggen P., Traversari C., Chomez P., Lurquin C., De Plaen E., Van den Eynde B., Knuth A., Boon T. A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma. Science 1991, 254:1643-1647.
38. Wang C., Ivanov A., Chen L., Fredericks W.J., Seto E., Rauscher F.J., Chen J. MDM2 interaction with nuclear corepressor KAP1 contributes to p53 inactivation. EMBO J. 2005, 24:3279-3290.
39. Yang B., O'Herrin S.M., Wu J., Reagan-Shaw S., Ma Y., Bhat K.M., Gravekamp C., Setaluri V., Peters N., Hoffmann F.M., et al. MAGE-A, mMage-b, and MAGE-C proteins form complexes with KAP1 and suppress p53-dependent apoptosis in MAGE-positive cell lines. Cancer Res. 2007, 67:9954-9962.
40. Yokoe T., Toiyama Y., Okugawa Y., Tanaka K., Ohi M., Inoue Y., Mohri Y., Miki C., Kusunoki M. KAP1 is associated with peritoneal carcinomatosis in gastric cancer. Ann. Surg. Oncol. 2010, 17:821-828.
41. Zhao G.Y., Sonoda E., Barber L.J., Oka H., Murakawa Y., Yamada K., Ikura T., Wang X., Kobayashi M., Yamamoto K., et al. A critical role for the ubiquitin-conjugating enzyme Ubc13 in initiating homologous recombination. Mol. Cell 2007, 25:663-675.
42. Zhuang R., Zhu Y., Fang L., Liu X.S., Tian Y., Chen L.H., Ouyang W.M., Xu X.G., Jian J.L., Güre A.O., et al. Generation of monoclonal antibodies to cancer/testis (CT) antigen CT10/MAGE-C2. Cancer Immun. 2006, 6:7.