메뉴 건너뛰기




Volumn 38, Issue 3, 2018, Pages 267-276

HIF Activation Against CVD in CKD: Novel Treatment Opportunities

Author keywords

CKD; CVD; HIF; PHD inhibitor

Indexed keywords

ANTIANEMIC AGENT; FIBROBLAST GROWTH FACTOR 23; HEMOGLOBIN; HYPOXIA INDUCIBLE FACTOR; HYPOXIA INDUCIBLE FACTOR 1; HYPOXIA INDUCIBLE FACTOR 2; INSULIN INDUCED GENE 2 PROTEIN; MEMBRANE PROTEIN; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE; PROLYL HYDROXYLASE INHIBITOR; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; VON HIPPEL LINDAU PROTEIN; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; ENDOTHELIAL PAS DOMAIN-CONTAINING PROTEIN 1; FIBROBLAST GROWTH FACTOR; HIF3A PROTEIN, HUMAN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 1BETA;

EID: 85046665675     PISSN: 02709295     EISSN: 15584488     Source Type: Journal    
DOI: 10.1016/j.semnephrol.2018.02.006     Document Type: Review
Times cited : (34)

References (83)
  • 1
    • 4644221457 scopus 로고    scopus 로고
    • Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization
    • Go, A.S., Chertow, G.M., Fan, D., et al. Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization. N Engl J Med 351 (2004), 1296–1305.
    • (2004) N Engl J Med , vol.351 , pp. 1296-1305
    • Go, A.S.1    Chertow, G.M.2    Fan, D.3
  • 2
    • 1642413198 scopus 로고    scopus 로고
    • Longitudinal follow-up and outcomes among a population with chronic kidney disease in a large managed care organization
    • Keith, D.S., Nichols, G.A., Gullion, C.M., et al. Longitudinal follow-up and outcomes among a population with chronic kidney disease in a large managed care organization. Arch Intern Med 164 (2004), 659–663.
    • (2004) Arch Intern Med , vol.164 , pp. 659-663
    • Keith, D.S.1    Nichols, G.A.2    Gullion, C.M.3
  • 3
    • 18544391171 scopus 로고    scopus 로고
    • The cardio-renal anaemia syndrome: does it exist?
    • Silverberg, D., Wexler, D., Blum, M., et al. The cardio-renal anaemia syndrome: does it exist?. Nephrol Dial Transplant 18:Suppl 8 (2003), viii7–viii12.
    • (2003) Nephrol Dial Transplant , vol.18 , pp. viii7-viii12
    • Silverberg, D.1    Wexler, D.2    Blum, M.3
  • 4
    • 84958920828 scopus 로고    scopus 로고
    • HIF prolyl hydroxylase inhibitors for the treatment of renal anaemia and beyond
    • Maxwell, P.H., Eckardt, K.U., HIF prolyl hydroxylase inhibitors for the treatment of renal anaemia and beyond. Nat Rev Nephrol 12 (2016), 157–168.
    • (2016) Nat Rev Nephrol , vol.12 , pp. 157-168
    • Maxwell, P.H.1    Eckardt, K.U.2
  • 5
    • 0345491599 scopus 로고    scopus 로고
    • Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation
    • Hu, C.J., Wang, L.Y., Chodosh, L.A., et al. Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation. Mol Cell Biol 23 (2003), 9361–9374.
    • (2003) Mol Cell Biol , vol.23 , pp. 9361-9374
    • Hu, C.J.1    Wang, L.Y.2    Chodosh, L.A.3
  • 6
    • 0041465022 scopus 로고    scopus 로고
    • HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia
    • Berra, E., Benizri, E., Ginouves, A., et al. HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia. EMBO J 22 (2003), 4082–4090.
    • (2003) EMBO J , vol.22 , pp. 4082-4090
    • Berra, E.1    Benizri, E.2    Ginouves, A.3
  • 7
    • 4644318828 scopus 로고    scopus 로고
    • Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor
    • Appelhoff, R.J., Tian, Y.M., Raval, R.R., et al. Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor. J Biol Chem 279 (2004), 38458–38465.
    • (2004) J Biol Chem , vol.279 , pp. 38458-38465
    • Appelhoff, R.J.1    Tian, Y.M.2    Raval, R.R.3
  • 8
    • 9444283176 scopus 로고    scopus 로고
    • Differentiating the functional role of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha (EPAS-1) by the use of RNA interference: erythropoietin is a HIF-2alpha target gene in Hep3B and Kelly cells
    • Warnecke, C., Zaborowska, Z., Kurreck, J., et al. Differentiating the functional role of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha (EPAS-1) by the use of RNA interference: erythropoietin is a HIF-2alpha target gene in Hep3B and Kelly cells. FASEB J 18 (2004), 1462–1464.
    • (2004) FASEB J , vol.18 , pp. 1462-1464
    • Warnecke, C.1    Zaborowska, Z.2    Kurreck, J.3
  • 9
    • 34047228387 scopus 로고    scopus 로고
    • Protective role of hypoxia-inducible factor-2alpha against ischemic damage and oxidative stress in the kidney
    • Kojima, I., Tanaka, T., Inagi, R., et al. Protective role of hypoxia-inducible factor-2alpha against ischemic damage and oxidative stress in the kidney. J Am Soc Nephrol 18 (2007), 1218–1226.
    • (2007) J Am Soc Nephrol , vol.18 , pp. 1218-1226
    • Kojima, I.1    Tanaka, T.2    Inagi, R.3
  • 10
    • 42449163874 scopus 로고    scopus 로고
    • Somatic inactivation of the PHD2 prolyl hydroxylase causes polycythemia and congestive heart failure
    • Minamishima, Y.A., Moslehi, J., Bardeesy, N., et al. Somatic inactivation of the PHD2 prolyl hydroxylase causes polycythemia and congestive heart failure. Blood 111 (2008), 3236–3244.
    • (2008) Blood , vol.111 , pp. 3236-3244
    • Minamishima, Y.A.1    Moslehi, J.2    Bardeesy, N.3
  • 11
    • 38049173572 scopus 로고    scopus 로고
    • A gain-of-function mutation in the HIF2A gene in familial erythrocytosis
    • Percy, M.J., Furlow, P.W., Lucas, G.S., et al. A gain-of-function mutation in the HIF2A gene in familial erythrocytosis. N Engl J Med 358 (2008), 162–168.
    • (2008) N Engl J Med , vol.358 , pp. 162-168
    • Percy, M.J.1    Furlow, P.W.2    Lucas, G.S.3
  • 12
    • 31444436640 scopus 로고    scopus 로고
    • A family with erythrocytosis establishes a role for prolyl hydroxylase domain protein 2 in oxygen homeostasis
    • Percy, M.J., Zhao, Q., Flores, A., et al. A family with erythrocytosis establishes a role for prolyl hydroxylase domain protein 2 in oxygen homeostasis. Proc Natl Acad Sci U S A 103 (2006), 654–659.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 654-659
    • Percy, M.J.1    Zhao, Q.2    Flores, A.3
  • 13
    • 85021195196 scopus 로고    scopus 로고
    • Prolyl hydroxylase domain inhibitors as a novel therapeutic approach against anemia in chronic kidney disease
    • Sugahara, M., Tanaka, T., Nangaku, M., Prolyl hydroxylase domain inhibitors as a novel therapeutic approach against anemia in chronic kidney disease. Kidney Int 92 (2017), 306–312.
    • (2017) Kidney Int , vol.92 , pp. 306-312
    • Sugahara, M.1    Tanaka, T.2    Nangaku, M.3
  • 14
    • 84878347460 scopus 로고    scopus 로고
    • Cardiovascular toxicity of epoetin-alfa in patients with chronic kidney disease
    • McCullough, P.A., Barnhart, H.X., Inrig, J.K., et al. Cardiovascular toxicity of epoetin-alfa in patients with chronic kidney disease. Am J Nephrol 37 (2013), 549–558.
    • (2013) Am J Nephrol , vol.37 , pp. 549-558
    • McCullough, P.A.1    Barnhart, H.X.2    Inrig, J.K.3
  • 15
    • 33751002326 scopus 로고    scopus 로고
    • Normalization of hemoglobin level in patients with chronic kidney disease and anemia
    • Drueke, T.B., Locatelli, F., Clyne, N., et al. Normalization of hemoglobin level in patients with chronic kidney disease and anemia. N Engl J Med 355 (2006), 2071–2084.
    • (2006) N Engl J Med , vol.355 , pp. 2071-2084
    • Drueke, T.B.1    Locatelli, F.2    Clyne, N.3
  • 16
    • 33750983605 scopus 로고    scopus 로고
    • Correction of anemia with epoetin alfa in chronic kidney disease
    • Singh, A.K., Szczech, L., Tang, K.L., et al. Correction of anemia with epoetin alfa in chronic kidney disease. N Engl J Med 355 (2006), 2085–2098.
    • (2006) N Engl J Med , vol.355 , pp. 2085-2098
    • Singh, A.K.1    Szczech, L.2    Tang, K.L.3
  • 17
    • 70949108082 scopus 로고    scopus 로고
    • A trial of darbepoetin alfa in type 2 diabetes and chronic kidney disease
    • Pfeffer, M.A., Burdmann, E.A., Chen, C.Y., et al. A trial of darbepoetin alfa in type 2 diabetes and chronic kidney disease. N Engl J Med 361 (2009), 2019–2032.
    • (2009) N Engl J Med , vol.361 , pp. 2019-2032
    • Pfeffer, M.A.1    Burdmann, E.A.2    Chen, C.Y.3
  • 18
    • 84884333035 scopus 로고    scopus 로고
    • KDIGO Clinical Practice Guideline for anemia in chronic kidney disease
    • KDIGO Clinical Practice Guideline for anemia in chronic kidney disease. Kidney Int Suppl 2 (2012), 279–335.
    • (2012) Kidney Int Suppl , vol.2 , pp. 279-335
  • 19
    • 28244446238 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1-alpha reduces infarction and attenuates progression of cardiac dysfunction after myocardial infarction in the mouse
    • Kido, M., Du, L., Sullivan, C.C., et al. Hypoxia-inducible factor 1-alpha reduces infarction and attenuates progression of cardiac dysfunction after myocardial infarction in the mouse. J Am Coll Cardiol 46 (2005), 2116–2124.
    • (2005) J Am Coll Cardiol , vol.46 , pp. 2116-2124
    • Kido, M.1    Du, L.2    Sullivan, C.C.3
  • 20
    • 47649128513 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1 is central to cardioprotection: a new paradigm for ischemic preconditioning
    • Eckle, T., Kohler, D., Lehmann, R., et al. Hypoxia-inducible factor-1 is central to cardioprotection: a new paradigm for ischemic preconditioning. Circulation 118 (2008), 166–175.
    • (2008) Circulation , vol.118 , pp. 166-175
    • Eckle, T.1    Kohler, D.2    Lehmann, R.3
  • 21
    • 79953179377 scopus 로고    scopus 로고
    • Cardiomyocyte-specific prolyl-4-hydroxylase domain 2 knock out protects from acute myocardial ischemic injury
    • Holscher, M., Silter, M., Krull, S., et al. Cardiomyocyte-specific prolyl-4-hydroxylase domain 2 knock out protects from acute myocardial ischemic injury. J Biol Chem 286 (2011), 11185–11194.
    • (2011) J Biol Chem , vol.286 , pp. 11185-11194
    • Holscher, M.1    Silter, M.2    Krull, S.3
  • 22
    • 77951552411 scopus 로고    scopus 로고
    • Hearts of hypoxia-inducible factor prolyl 4-hydroxylase-2 hypomorphic mice show protection against acute ischemia-reperfusion injury
    • Hyvarinen, J., Hassinen, I.E., Sormunen, R., et al. Hearts of hypoxia-inducible factor prolyl 4-hydroxylase-2 hypomorphic mice show protection against acute ischemia-reperfusion injury. J Biol Chem 285 (2010), 13646–13657.
    • (2010) J Biol Chem , vol.285 , pp. 13646-13657
    • Hyvarinen, J.1    Hassinen, I.E.2    Sormunen, R.3
  • 23
    • 84941357822 scopus 로고    scopus 로고
    • Pre- and post-conditional inhibition of prolyl-4-hydroxylase domain enzymes protects the heart from an ischemic insult
    • Vogler, M., Zieseniss, A., Hesse, A.R., et al. Pre- and post-conditional inhibition of prolyl-4-hydroxylase domain enzymes protects the heart from an ischemic insult. Pflugers Arch 467 (2015), 2141–2149.
    • (2015) Pflugers Arch , vol.467 , pp. 2141-2149
    • Vogler, M.1    Zieseniss, A.2    Hesse, A.R.3
  • 24
    • 77957254118 scopus 로고    scopus 로고
    • Loss of hypoxia-inducible factor prolyl hydroxylase activity in cardiomyocytes phenocopies ischemic cardiomyopathy
    • Moslehi, J., Minamishima, Y.A., Shi, J., et al. Loss of hypoxia-inducible factor prolyl hydroxylase activity in cardiomyocytes phenocopies ischemic cardiomyopathy. Circulation 122 (2010), 1004–1016.
    • (2010) Circulation , vol.122 , pp. 1004-1016
    • Moslehi, J.1    Minamishima, Y.A.2    Shi, J.3
  • 25
    • 43649100536 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-dependent degeneration, failure, and malignant transformation of the heart in the absence of the von Hippel-Lindau protein
    • Lei, L., Mason, S., Liu, D., et al. Hypoxia-inducible factor-dependent degeneration, failure, and malignant transformation of the heart in the absence of the von Hippel-Lindau protein. Mol Cell Biol 28 (2008), 3790–3803.
    • (2008) Mol Cell Biol , vol.28 , pp. 3790-3803
    • Lei, L.1    Mason, S.2    Liu, D.3
  • 26
    • 66049097308 scopus 로고    scopus 로고
    • Activation of a HIF1alpha-PPARgamma axis underlies the integration of glycolytic and lipid anabolic pathways in pathologic cardiac hypertrophy
    • Krishnan, J., Suter, M., Windak, R., et al. Activation of a HIF1alpha-PPARgamma axis underlies the integration of glycolytic and lipid anabolic pathways in pathologic cardiac hypertrophy. Cell Metab 9 (2009), 512–524.
    • (2009) Cell Metab , vol.9 , pp. 512-524
    • Krishnan, J.1    Suter, M.2    Windak, R.3
  • 27
    • 33947520124 scopus 로고    scopus 로고
    • p53-induced inhibition of Hif-1 causes cardiac dysfunction during pressure overload
    • Sano, M., Minamino, T., Toko, H., et al. p53-induced inhibition of Hif-1 causes cardiac dysfunction during pressure overload. Nature 446 (2007), 444–448.
    • (2007) Nature , vol.446 , pp. 444-448
    • Sano, M.1    Minamino, T.2    Toko, H.3
  • 28
    • 84859469406 scopus 로고    scopus 로고
    • Endothelial expression of hypoxia-inducible factor 1 protects the murine heart and aorta from pressure overload by suppression of TGF-beta signaling
    • Wei, H., Bedja, D., Koitabashi, N., et al. Endothelial expression of hypoxia-inducible factor 1 protects the murine heart and aorta from pressure overload by suppression of TGF-beta signaling. Proc Natl Acad Sci U S A 109 (2012), E841–E850.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. E841-E850
    • Wei, H.1    Bedja, D.2    Koitabashi, N.3
  • 29
    • 0025286817 scopus 로고
    • Elevated circulating levels of tumor necrosis factor in severe chronic heart failure
    • Levine, B., Kalman, J., Mayer, L., et al. Elevated circulating levels of tumor necrosis factor in severe chronic heart failure. N Engl J Med 323 (1990), 236–241.
    • (1990) N Engl J Med , vol.323 , pp. 236-241
    • Levine, B.1    Kalman, J.2    Mayer, L.3
  • 30
    • 0034687595 scopus 로고    scopus 로고
    • Plasma cytokine parameters and mortality in patients with chronic heart failure
    • Rauchhaus, M., Doehner, W., Francis, D.P., et al. Plasma cytokine parameters and mortality in patients with chronic heart failure. Circulation 102 (2000), 3060–3067.
    • (2000) Circulation , vol.102 , pp. 3060-3067
    • Rauchhaus, M.1    Doehner, W.2    Francis, D.P.3
  • 31
    • 36549033197 scopus 로고    scopus 로고
    • The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions
    • Nahrendorf, M., Swirski, F.K., Aikawa, E., et al. The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions. J Exp Med 204 (2007), 3037–3047.
    • (2007) J Exp Med , vol.204 , pp. 3037-3047
    • Nahrendorf, M.1    Swirski, F.K.2    Aikawa, E.3
  • 32
    • 0028786601 scopus 로고
    • A hypoxia-responsive element mediates a novel pathway of activation of the inducible nitric oxide synthase promoter
    • Melillo, G., Musso, T., Sica, A., et al. A hypoxia-responsive element mediates a novel pathway of activation of the inducible nitric oxide synthase promoter. J Exp Med 182 (1995), 1683–1693.
    • (1995) J Exp Med , vol.182 , pp. 1683-1693
    • Melillo, G.1    Musso, T.2    Sica, A.3
  • 33
    • 84970028181 scopus 로고    scopus 로고
    • HIF-1alpha-PDK1 axis-induced active glycolysis plays an essential role in macrophage migratory capacity
    • Semba, H., Takeda, N., Isagawa, T., et al. HIF-1alpha-PDK1 axis-induced active glycolysis plays an essential role in macrophage migratory capacity. Nat Commun, 7, 2016, 11635.
    • (2016) Nat Commun , vol.7 , pp. 11635
    • Semba, H.1    Takeda, N.2    Isagawa, T.3
  • 34
    • 0037423948 scopus 로고    scopus 로고
    • HIF-1alpha is essential for myeloid cell-mediated inflammation
    • Cramer, T., Yamanishi, Y., Clausen, B.E., et al. HIF-1alpha is essential for myeloid cell-mediated inflammation. Cell 112 (2003), 645–657.
    • (2003) Cell , vol.112 , pp. 645-657
    • Cramer, T.1    Yamanishi, Y.2    Clausen, B.E.3
  • 35
    • 85028944616 scopus 로고    scopus 로고
    • Prolyl hydroxylase 2 inactivation enhances glycogen storage and promotes excessive neutrophilic responses
    • Sadiku, P., Willson, J.A., Dickinson, R.S., et al. Prolyl hydroxylase 2 inactivation enhances glycogen storage and promotes excessive neutrophilic responses. J Clin Invest 127 (2017), 3407–3420.
    • (2017) J Clin Invest , vol.127 , pp. 3407-3420
    • Sadiku, P.1    Willson, J.A.2    Dickinson, R.S.3
  • 36
    • 79958724181 scopus 로고    scopus 로고
    • Fibroblast growth factor 23 and risks of mortality and end-stage renal disease in patients with chronic kidney disease
    • Isakova, T., Xie, H., Yang, W., et al. Fibroblast growth factor 23 and risks of mortality and end-stage renal disease in patients with chronic kidney disease. JAMA 305 (2011), 2432–2439.
    • (2011) JAMA , vol.305 , pp. 2432-2439
    • Isakova, T.1    Xie, H.2    Yang, W.3
  • 37
    • 85020295627 scopus 로고    scopus 로고
    • Fibroblast growth factor 23: mineral metabolism and beyond
    • Grabner, A., Mazzaferro, S., Cianciolo, G., et al. Fibroblast growth factor 23: mineral metabolism and beyond. Contrib Nephrol 190 (2017), 83–95.
    • (2017) Contrib Nephrol , vol.190 , pp. 83-95
    • Grabner, A.1    Mazzaferro, S.2    Cianciolo, G.3
  • 38
    • 80555148939 scopus 로고    scopus 로고
    • FGF23 induces left ventricular hypertrophy
    • Faul, C., Amaral, A.P., Oskouei, B., et al. FGF23 induces left ventricular hypertrophy. J Clin Invest 121 (2011), 4393–4408.
    • (2011) J Clin Invest , vol.121 , pp. 4393-4408
    • Faul, C.1    Amaral, A.P.2    Oskouei, B.3
  • 39
    • 84945942478 scopus 로고    scopus 로고
    • Activation of cardiac fibroblast growth factor receptor 4 causes left ventricular hypertrophy
    • Grabner, A., Amaral, A.P., Schramm, K., et al. Activation of cardiac fibroblast growth factor receptor 4 causes left ventricular hypertrophy. Cell Metab 22 (2015), 1020–1032.
    • (2015) Cell Metab , vol.22 , pp. 1020-1032
    • Grabner, A.1    Amaral, A.P.2    Schramm, K.3
  • 40
    • 84946130633 scopus 로고    scopus 로고
    • Inflammation and functional iron deficiency regulate fibroblast growth factor 23 production
    • David, V., Martin, A., Isakova, T., et al. Inflammation and functional iron deficiency regulate fibroblast growth factor 23 production. Kidney Int 89 (2016), 135–146.
    • (2016) Kidney Int , vol.89 , pp. 135-146
    • David, V.1    Martin, A.2    Isakova, T.3
  • 41
    • 85032445513 scopus 로고    scopus 로고
    • FGF23 expression in rodents is directly induced via erythropoietin after inhibition of hypoxia inducible factor proline hydroxylase
    • Flamme, I., Ellinghaus, P., Urrego, D., et al. FGF23 expression in rodents is directly induced via erythropoietin after inhibition of hypoxia inducible factor proline hydroxylase. PLoS One, 12, 2017, e0186979.
    • (2017) PLoS One , vol.12 , pp. e0186979
    • Flamme, I.1    Ellinghaus, P.2    Urrego, D.3
  • 42
    • 85019043941 scopus 로고    scopus 로고
    • High fibroblast growth factor 23 levels are associated with decreased ferritin levels and increased intravenous iron doses in hemodialysis patients
    • Honda, H., Michihata, T., Shishido, K., et al. High fibroblast growth factor 23 levels are associated with decreased ferritin levels and increased intravenous iron doses in hemodialysis patients. PLoS One, 12, 2017, e0176984.
    • (2017) PLoS One , vol.12 , pp. e0176984
    • Honda, H.1    Michihata, T.2    Shishido, K.3
  • 43
    • 0001507064 scopus 로고
    • The terminal portion of the pulmonary arterial tree in people native to high altitudes
    • Arias-Stella, J., Saldana, M., The terminal portion of the pulmonary arterial tree in people native to high altitudes. Circulation 28 (1963), 915–925.
    • (1963) Circulation , vol.28 , pp. 915-925
    • Arias-Stella, J.1    Saldana, M.2
  • 44
    • 50949133897 scopus 로고    scopus 로고
    • Autosomal dominant erythrocytosis and pulmonary arterial hypertension associated with an activating HIF2 alpha mutation
    • Gale, D.P., Harten, S.K., Reid, C.D., et al. Autosomal dominant erythrocytosis and pulmonary arterial hypertension associated with an activating HIF2 alpha mutation. Blood 112 (2008), 919–921.
    • (2008) Blood , vol.112 , pp. 919-921
    • Gale, D.P.1    Harten, S.K.2    Reid, C.D.3
  • 45
    • 85017532095 scopus 로고    scopus 로고
    • Cardiopulmonary phenotype associated with human PHD2 mutation
    • Talbot, N.P., Smith, T.G., Balanos, G.M., et al. Cardiopulmonary phenotype associated with human PHD2 mutation. Physiol Rep, 5, 2017, 7.
    • (2017) Physiol Rep , vol.5 , pp. 7
    • Talbot, N.P.1    Smith, T.G.2    Balanos, G.M.3
  • 46
    • 33746398489 scopus 로고    scopus 로고
    • Mutation of von Hippel-Lindau tumour suppressor and human cardiopulmonary physiology
    • Smith, T.G., Brooks, J.T., Balanos, G.M., et al. Mutation of von Hippel-Lindau tumour suppressor and human cardiopulmonary physiology. PLoS Med, 3, 2006, e290.
    • (2006) PLoS Med , vol.3 , pp. e290
    • Smith, T.G.1    Brooks, J.T.2    Balanos, G.M.3
  • 47
    • 84922391897 scopus 로고    scopus 로고
    • A genetic mechanism for Tibetan high-altitude adaptation
    • Lorenzo, F.R., Huff, C., Myllymaki, M., et al. A genetic mechanism for Tibetan high-altitude adaptation. Nat Genet 46 (2014), 951–956.
    • (2014) Nat Genet , vol.46 , pp. 951-956
    • Lorenzo, F.R.1    Huff, C.2    Myllymaki, M.3
  • 48
    • 84901217970 scopus 로고
    • Tibetans living at sea level have a hyporesponsive hypoxia-inducible factor system and blunted physiological responses to hypoxia
    • Petousi, N., Croft, Q.P., Cavalleri, G.L., et al. Tibetans living at sea level have a hyporesponsive hypoxia-inducible factor system and blunted physiological responses to hypoxia. J Appl Physiol 116 (1985), 893–904.
    • (1985) J Appl Physiol , vol.116 , pp. 893-904
    • Petousi, N.1    Croft, Q.P.2    Cavalleri, G.L.3
  • 49
    • 85047691081 scopus 로고    scopus 로고
    • Heterozygous deficiency of hypoxia-inducible factor-2alpha protects mice against pulmonary hypertension and right ventricular dysfunction during prolonged hypoxia
    • Brusselmans, K., Compernolle, V., Tjwa, M., et al. Heterozygous deficiency of hypoxia-inducible factor-2alpha protects mice against pulmonary hypertension and right ventricular dysfunction during prolonged hypoxia. J Clin Invest 111 (2003), 1519–1527.
    • (2003) J Clin Invest , vol.111 , pp. 1519-1527
    • Brusselmans, K.1    Compernolle, V.2    Tjwa, M.3
  • 50
    • 84982671719 scopus 로고    scopus 로고
    • HIF2alpha-arginase axis is essential for the development of pulmonary hypertension
    • Cowburn, A.S., Crosby, A., Macias, D., et al. HIF2alpha-arginase axis is essential for the development of pulmonary hypertension. Proc Natl Acad Sci U S A 113 (2016), 8801–8806.
    • (2016) Proc Natl Acad Sci U S A , vol.113 , pp. 8801-8806
    • Cowburn, A.S.1    Crosby, A.2    Macias, D.3
  • 51
    • 84879037862 scopus 로고    scopus 로고
    • Erythrocytosis and pulmonary hypertension in a mouse model of human HIF2A gain of function mutation
    • Tan, Q., Kerestes, H., Percy, M.J., et al. Erythrocytosis and pulmonary hypertension in a mouse model of human HIF2A gain of function mutation. J Biol Chem 288 (2013), 17134–17144.
    • (2013) J Biol Chem , vol.288 , pp. 17134-17144
    • Tan, Q.1    Kerestes, H.2    Percy, M.J.3
  • 53
  • 54
    • 40849086607 scopus 로고    scopus 로고
    • Hypoxia, hypoxia-inducible transcription factor, and macrophages in human atherosclerotic plaques are correlated with intraplaque angiogenesis
    • Sluimer, J.C., Gasc, J.M., van Wanroij, J.L., et al. Hypoxia, hypoxia-inducible transcription factor, and macrophages in human atherosclerotic plaques are correlated with intraplaque angiogenesis. J Am Coll Cardiol 51 (2008), 1258–1265.
    • (2008) J Am Coll Cardiol , vol.51 , pp. 1258-1265
    • Sluimer, J.C.1    Gasc, J.M.2    van Wanroij, J.L.3
  • 55
    • 84945477011 scopus 로고    scopus 로고
    • Deficiency of HIF1alpha in antigen-presenting cells aggravates atherosclerosis and type 1 T-helper cell responses in mice
    • Chaudhari, S.M., Sluimer, J.C., Koch, M., et al. Deficiency of HIF1alpha in antigen-presenting cells aggravates atherosclerosis and type 1 T-helper cell responses in mice. Arterioscler Thromb Vasc Biol 35 (2015), 2316–2325.
    • (2015) Arterioscler Thromb Vasc Biol , vol.35 , pp. 2316-2325
    • Chaudhari, S.M.1    Sluimer, J.C.2    Koch, M.3
  • 56
    • 84979662970 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1alpha expression in macrophages promotes development of atherosclerosis
    • Aarup, A., Pedersen, T.X., Junker, N., et al. Hypoxia-inducible factor-1alpha expression in macrophages promotes development of atherosclerosis. Arterioscler Thromb Vasc Biol 36 (2016), 1782–1790.
    • (2016) Arterioscler Thromb Vasc Biol , vol.36 , pp. 1782-1790
    • Aarup, A.1    Pedersen, T.X.2    Junker, N.3
  • 57
    • 0032528913 scopus 로고    scopus 로고
    • Identification of the lectin-like receptor for oxidized low-density lipoprotein in human macrophages and its potential role as a scavenger receptor
    • Yoshida, H., Kondratenko, N., Green, S., et al. Identification of the lectin-like receptor for oxidized low-density lipoprotein in human macrophages and its potential role as a scavenger receptor. Biochem J 334 (1998), 9–13.
    • (1998) Biochem J , vol.334 , pp. 9-13
    • Yoshida, H.1    Kondratenko, N.2    Green, S.3
  • 58
    • 84879421653 scopus 로고    scopus 로고
    • Hypoxia enhances lipid uptake in macrophages: role of the scavenger receptors Lox1, SRA, and CD36
    • Crucet, M., Wust, S.J., Spielmann, P., et al. Hypoxia enhances lipid uptake in macrophages: role of the scavenger receptors Lox1, SRA, and CD36. Atherosclerosis 229 (2013), 110–117.
    • (2013) Atherosclerosis , vol.229 , pp. 110-117
    • Crucet, M.1    Wust, S.J.2    Spielmann, P.3
  • 59
    • 0035993485 scopus 로고    scopus 로고
    • LOX-1, the receptor for oxidized low-density lipoprotein identified from endothelial cells: implications in endothelial dysfunction and atherosclerosis
    • Chen, M., Masaki, T., Sawamura, T., LOX-1, the receptor for oxidized low-density lipoprotein identified from endothelial cells: implications in endothelial dysfunction and atherosclerosis. Pharmacol Ther 95 (2002), 89–100.
    • (2002) Pharmacol Ther , vol.95 , pp. 89-100
    • Chen, M.1    Masaki, T.2    Sawamura, T.3
  • 60
    • 3042734510 scopus 로고    scopus 로고
    • Decreased number and impaired angiogenic function of endothelial progenitor cells in patients with chronic renal failure
    • Choi, J.H., Kim, K.L., Huh, W., et al. Decreased number and impaired angiogenic function of endothelial progenitor cells in patients with chronic renal failure. Arterioscler Thromb Vasc Biol 24 (2004), 1246–1252.
    • (2004) Arterioscler Thromb Vasc Biol , vol.24 , pp. 1246-1252
    • Choi, J.H.1    Kim, K.L.2    Huh, W.3
  • 61
    • 70349895636 scopus 로고    scopus 로고
    • The soluble VEGF receptor sFlt1 contributes to endothelial dysfunction in CKD
    • Di Marco, G.S., Reuter, S., Hillebrand, U., et al. The soluble VEGF receptor sFlt1 contributes to endothelial dysfunction in CKD. J Am Soc Nephrol 20 (2009), 2235–2245.
    • (2009) J Am Soc Nephrol , vol.20 , pp. 2235-2245
    • Di Marco, G.S.1    Reuter, S.2    Hillebrand, U.3
  • 62
    • 85008319247 scopus 로고    scopus 로고
    • Hypoxia inducible factor stabilization improves defective ischemia-induced angiogenesis in a rodent model of chronic kidney disease
    • Schellinger, I.N., Cordasic, N., Panesar, J., et al. Hypoxia inducible factor stabilization improves defective ischemia-induced angiogenesis in a rodent model of chronic kidney disease. Kidney Int 91 (2017), 616–627.
    • (2017) Kidney Int , vol.91 , pp. 616-627
    • Schellinger, I.N.1    Cordasic, N.2    Panesar, J.3
  • 63
    • 84973320456 scopus 로고    scopus 로고
    • Oral hypoxia-inducible factor prolyl hydroxylase inhibitor roxadustat (FG-4592) for the treatment of anemia in patients with CKD
    • Provenzano, R., Besarab, A., Sun, C.H., et al. Oral hypoxia-inducible factor prolyl hydroxylase inhibitor roxadustat (FG-4592) for the treatment of anemia in patients with CKD. Clin J Am Soc Nephrol 11 (2016), 982–991.
    • (2016) Clin J Am Soc Nephrol , vol.11 , pp. 982-991
    • Provenzano, R.1    Besarab, A.2    Sun, C.H.3
  • 64
    • 84956633361 scopus 로고    scopus 로고
    • Roxadustat (FG-4592) versus epoetin alfa for anemia in patients receiving maintenance hemodialysis: a phase 2, randomized, 6- to 19-week, open-label, active-comparator, dose-ranging, safety and exploratory efficacy study
    • Provenzano, R., Besarab, A., Wright, S., et al. Roxadustat (FG-4592) versus epoetin alfa for anemia in patients receiving maintenance hemodialysis: a phase 2, randomized, 6- to 19-week, open-label, active-comparator, dose-ranging, safety and exploratory efficacy study. Am J Kidney Dis 67 (2016), 912–924.
    • (2016) Am J Kidney Dis , vol.67 , pp. 912-924
    • Provenzano, R.1    Besarab, A.2    Wright, S.3
  • 65
    • 85008384570 scopus 로고    scopus 로고
    • Effects of daprodustat, a novel hypoxia-inducible factor prolyl hydroxylase inhibitor on anemia management in Japanese hemodialysis subjects
    • Akizawa, T., Tsubakihara, Y., Nangaku, M., et al. Effects of daprodustat, a novel hypoxia-inducible factor prolyl hydroxylase inhibitor on anemia management in Japanese hemodialysis subjects. Am J Nephrol 45 (2017), 127–135.
    • (2017) Am J Nephrol , vol.45 , pp. 127-135
    • Akizawa, T.1    Tsubakihara, Y.2    Nangaku, M.3
  • 66
    • 85016641947 scopus 로고    scopus 로고
    • Clinical trial of vadadustat in patients with anemia secondary to stage 3 or 4 chronic kidney disease
    • Martin, E.R., Smith, M.T., Maroni, B.J., et al. Clinical trial of vadadustat in patients with anemia secondary to stage 3 or 4 chronic kidney disease. Am J Nephrol 45 (2017), 380–388.
    • (2017) Am J Nephrol , vol.45 , pp. 380-388
    • Martin, E.R.1    Smith, M.T.2    Maroni, B.J.3
  • 67
    • 84907481900 scopus 로고    scopus 로고
    • HIF prolyl 4-hydroxylase-2 inhibition improves glucose and lipid metabolism and protects against obesity and metabolic dysfunction
    • Rahtu-Korpela, L., Karsikas, S., Horkko, S., et al. HIF prolyl 4-hydroxylase-2 inhibition improves glucose and lipid metabolism and protects against obesity and metabolic dysfunction. Diabetes 63 (2014), 3324–3333.
    • (2014) Diabetes , vol.63 , pp. 3324-3333
    • Rahtu-Korpela, L.1    Karsikas, S.2    Horkko, S.3
  • 68
    • 84878313576 scopus 로고    scopus 로고
    • Prolyl hydroxylase domain protein 2 plays a critical role in diet-induced obesity and glucose intolerance
    • Matsuura, H., Ichiki, T., Inoue, E., et al. Prolyl hydroxylase domain protein 2 plays a critical role in diet-induced obesity and glucose intolerance. Circulation 127 (2013), 2078–2087.
    • (2013) Circulation , vol.127 , pp. 2078-2087
    • Matsuura, H.1    Ichiki, T.2    Inoue, E.3
  • 69
    • 85020299178 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1alpha activates insulin-induced gene 2 (Insig-2) transcription for degradation of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase in the liver
    • Hwang, S., Nguyen, A.D., Jo, Y., et al. Hypoxia-inducible factor 1alpha activates insulin-induced gene 2 (Insig-2) transcription for degradation of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase in the liver. J Biol Chem 292 (2017), 9382–9393.
    • (2017) J Biol Chem , vol.292 , pp. 9382-9393
    • Hwang, S.1    Nguyen, A.D.2    Jo, Y.3
  • 70
    • 84994336731 scopus 로고    scopus 로고
    • Deficiency of the oxygen sensor prolyl hydroxylase 1 attenuates hypercholesterolaemia, atherosclerosis, and hyperglycaemia
    • Marsch, E., Demandt, J.A., Theelen, T.L., et al. Deficiency of the oxygen sensor prolyl hydroxylase 1 attenuates hypercholesterolaemia, atherosclerosis, and hyperglycaemia. Eur Heart J 37 (2016), 2993–2997.
    • (2016) Eur Heart J , vol.37 , pp. 2993-2997
    • Marsch, E.1    Demandt, J.A.2    Theelen, T.L.3
  • 71
    • 85016925358 scopus 로고    scopus 로고
    • Roxadustat (FG-4592): correction of anemia in incident dialysis patients
    • Besarab, A., Chernyavskaya, E., Motylev, I., et al. Roxadustat (FG-4592): correction of anemia in incident dialysis patients. J Am Soc Nephrol 27 (2016), 1225–1233.
    • (2016) J Am Soc Nephrol , vol.27 , pp. 1225-1233
    • Besarab, A.1    Chernyavskaya, E.2    Motylev, I.3
  • 72
    • 84994143390 scopus 로고    scopus 로고
    • Vadadustat, a novel oral HIF stabilizer, provides effective anemia treatment in nondialysis-dependent chronic kidney disease
    • Pergola, P.E., Spinowitz, B.S., Hartman, C.S., et al. Vadadustat, a novel oral HIF stabilizer, provides effective anemia treatment in nondialysis-dependent chronic kidney disease. Kidney Int 90 (2016), 1115–1122.
    • (2016) Kidney Int , vol.90 , pp. 1115-1122
    • Pergola, P.E.1    Spinowitz, B.S.2    Hartman, C.S.3
  • 73
    • 0034919301 scopus 로고    scopus 로고
    • Novel erythropoiesis stimulating protein for treatment of anemia in chronic renal insufficiency
    • Locatelli, F., Olivares, J., Walker, R., et al. Novel erythropoiesis stimulating protein for treatment of anemia in chronic renal insufficiency. Kidney Int 60 (2001), 741–747.
    • (2001) Kidney Int , vol.60 , pp. 741-747
    • Locatelli, F.1    Olivares, J.2    Walker, R.3
  • 74
    • 84911895497 scopus 로고    scopus 로고
    • Mimicking hypoxia to treat anemia: HIF-stabilizer BAY 85-3934 (Molidustat) stimulates erythropoietin production without hypertensive effects
    • Flamme, I., Oehme, F., Ellinghaus, P., et al. Mimicking hypoxia to treat anemia: HIF-stabilizer BAY 85-3934 (Molidustat) stimulates erythropoietin production without hypertensive effects. PLoS One, 9, 2014, e111838.
    • (2014) PLoS One , vol.9 , pp. e111838
    • Flamme, I.1    Oehme, F.2    Ellinghaus, P.3
  • 75
    • 84886414629 scopus 로고    scopus 로고
    • HIF isoforms in the skin differentially regulate systemic arterial pressure
    • Cowburn, A.S., Takeda, N., Boutin, A.T., et al. HIF isoforms in the skin differentially regulate systemic arterial pressure. Proc Natl Acad Sci U S A 110 (2013), 17570–17575.
    • (2013) Proc Natl Acad Sci U S A , vol.110 , pp. 17570-17575
    • Cowburn, A.S.1    Takeda, N.2    Boutin, A.T.3
  • 76
    • 77649177217 scopus 로고    scopus 로고
    • Differential activation and antagonistic function of HIF-{alpha} isoforms in macrophages are essential for NO homeostasis
    • Takeda, N., O'Dea, E.L., Doedens, A., et al. Differential activation and antagonistic function of HIF-{alpha} isoforms in macrophages are essential for NO homeostasis. Genes Dev 24 (2010), 491–501.
    • (2010) Genes Dev , vol.24 , pp. 491-501
    • Takeda, N.1    O'Dea, E.L.2    Doedens, A.3
  • 77
    • 43249108443 scopus 로고    scopus 로고
    • Abnormal sympathoadrenal development and systemic hypotension in PHD3-/- mice
    • Bishop, T., Gallagher, D., Pascual, A., et al. Abnormal sympathoadrenal development and systemic hypotension in PHD3-/- mice. Mol Cell Biol 28 (2008), 3386–3400.
    • (2008) Mol Cell Biol , vol.28 , pp. 3386-3400
    • Bishop, T.1    Gallagher, D.2    Pascual, A.3
  • 78
    • 79952609061 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 2alpha (HIF-2alpha) heterozygous-null mice exhibit exaggerated carotid body sensitivity to hypoxia, breathing instability, and hypertension
    • Peng, Y.J., Nanduri, J., Khan, S.A., et al. Hypoxia-inducible factor 2alpha (HIF-2alpha) heterozygous-null mice exhibit exaggerated carotid body sensitivity to hypoxia, breathing instability, and hypertension. Proc Natl Acad Sci U S A 108 (2011), 3065–3070.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 3065-3070
    • Peng, Y.J.1    Nanduri, J.2    Khan, S.A.3
  • 79
    • 77951463662 scopus 로고    scopus 로고
    • Hypoxia-inducible factor prolyl-hydroxylase 2 senses high-salt intake to increase hypoxia inducible factor 1alpha levels in the renal medulla
    • Wang, Z., Zhu, Q., Xia, M., et al. Hypoxia-inducible factor prolyl-hydroxylase 2 senses high-salt intake to increase hypoxia inducible factor 1alpha levels in the renal medulla. Hypertension 55 (2010), 1129–1136.
    • (2010) Hypertension , vol.55 , pp. 1129-1136
    • Wang, Z.1    Zhu, Q.2    Xia, M.3
  • 80
    • 84859042920 scopus 로고    scopus 로고
    • Overexpression of HIF-1alpha transgene in the renal medulla attenuated salt sensitive hypertension in Dahl S rats
    • Zhu, Q., Wang, Z., Xia, M., et al. Overexpression of HIF-1alpha transgene in the renal medulla attenuated salt sensitive hypertension in Dahl S rats. Biochim Biophys Acta 1822 (2012), 936–941.
    • (2012) Biochim Biophys Acta , vol.1822 , pp. 936-941
    • Zhu, Q.1    Wang, Z.2    Xia, M.3
  • 81
    • 84890505292 scopus 로고    scopus 로고
    • Silencing of HIF prolyl-hydroxylase 2 gene in the renal medulla attenuates salt-sensitive hypertension in Dahl S rats
    • Zhu, Q., Hu, J., Han, W.Q., et al. Silencing of HIF prolyl-hydroxylase 2 gene in the renal medulla attenuates salt-sensitive hypertension in Dahl S rats. Am J Hypertens 27 (2014), 107–113.
    • (2014) Am J Hypertens , vol.27 , pp. 107-113
    • Zhu, Q.1    Hu, J.2    Han, W.Q.3
  • 82
    • 84974659924 scopus 로고    scopus 로고
    • Correction: adipose tissue-derived mesenchymal stem cells in long-term dialysis patients display downregulation of PCAF expression and poor angiogenesis activation
    • Yamanaka, S., Yokote, S., Yamada, A., et al. Correction: adipose tissue-derived mesenchymal stem cells in long-term dialysis patients display downregulation of PCAF expression and poor angiogenesis activation. PLoS One, 11, 2016, e0157282.
    • (2016) PLoS One , vol.11 , pp. e0157282
    • Yamanaka, S.1    Yokote, S.2    Yamada, A.3
  • 83
    • 84938553872 scopus 로고    scopus 로고
    • Inflammation and hypoxia linked to renal injury by CCAAT/enhancer-binding protein delta
    • Yamaguchi, J., Tanaka, T., Eto, N., et al. Inflammation and hypoxia linked to renal injury by CCAAT/enhancer-binding protein delta. Kidney Int 88 (2015), 262–275.
    • (2015) Kidney Int , vol.88 , pp. 262-275
    • Yamaguchi, J.1    Tanaka, T.2    Eto, N.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.