-
1
-
-
4644221457
-
Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization
-
Go, A.S., Chertow, G.M., Fan, D., et al. Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization. N Engl J Med 351 (2004), 1296–1305.
-
(2004)
N Engl J Med
, vol.351
, pp. 1296-1305
-
-
Go, A.S.1
Chertow, G.M.2
Fan, D.3
-
2
-
-
1642413198
-
Longitudinal follow-up and outcomes among a population with chronic kidney disease in a large managed care organization
-
Keith, D.S., Nichols, G.A., Gullion, C.M., et al. Longitudinal follow-up and outcomes among a population with chronic kidney disease in a large managed care organization. Arch Intern Med 164 (2004), 659–663.
-
(2004)
Arch Intern Med
, vol.164
, pp. 659-663
-
-
Keith, D.S.1
Nichols, G.A.2
Gullion, C.M.3
-
3
-
-
18544391171
-
The cardio-renal anaemia syndrome: does it exist?
-
Silverberg, D., Wexler, D., Blum, M., et al. The cardio-renal anaemia syndrome: does it exist?. Nephrol Dial Transplant 18:Suppl 8 (2003), viii7–viii12.
-
(2003)
Nephrol Dial Transplant
, vol.18
, pp. viii7-viii12
-
-
Silverberg, D.1
Wexler, D.2
Blum, M.3
-
4
-
-
84958920828
-
HIF prolyl hydroxylase inhibitors for the treatment of renal anaemia and beyond
-
Maxwell, P.H., Eckardt, K.U., HIF prolyl hydroxylase inhibitors for the treatment of renal anaemia and beyond. Nat Rev Nephrol 12 (2016), 157–168.
-
(2016)
Nat Rev Nephrol
, vol.12
, pp. 157-168
-
-
Maxwell, P.H.1
Eckardt, K.U.2
-
5
-
-
0345491599
-
Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation
-
Hu, C.J., Wang, L.Y., Chodosh, L.A., et al. Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation. Mol Cell Biol 23 (2003), 9361–9374.
-
(2003)
Mol Cell Biol
, vol.23
, pp. 9361-9374
-
-
Hu, C.J.1
Wang, L.Y.2
Chodosh, L.A.3
-
6
-
-
0041465022
-
HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia
-
Berra, E., Benizri, E., Ginouves, A., et al. HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia. EMBO J 22 (2003), 4082–4090.
-
(2003)
EMBO J
, vol.22
, pp. 4082-4090
-
-
Berra, E.1
Benizri, E.2
Ginouves, A.3
-
7
-
-
4644318828
-
Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor
-
Appelhoff, R.J., Tian, Y.M., Raval, R.R., et al. Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor. J Biol Chem 279 (2004), 38458–38465.
-
(2004)
J Biol Chem
, vol.279
, pp. 38458-38465
-
-
Appelhoff, R.J.1
Tian, Y.M.2
Raval, R.R.3
-
8
-
-
9444283176
-
Differentiating the functional role of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha (EPAS-1) by the use of RNA interference: erythropoietin is a HIF-2alpha target gene in Hep3B and Kelly cells
-
Warnecke, C., Zaborowska, Z., Kurreck, J., et al. Differentiating the functional role of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha (EPAS-1) by the use of RNA interference: erythropoietin is a HIF-2alpha target gene in Hep3B and Kelly cells. FASEB J 18 (2004), 1462–1464.
-
(2004)
FASEB J
, vol.18
, pp. 1462-1464
-
-
Warnecke, C.1
Zaborowska, Z.2
Kurreck, J.3
-
9
-
-
34047228387
-
Protective role of hypoxia-inducible factor-2alpha against ischemic damage and oxidative stress in the kidney
-
Kojima, I., Tanaka, T., Inagi, R., et al. Protective role of hypoxia-inducible factor-2alpha against ischemic damage and oxidative stress in the kidney. J Am Soc Nephrol 18 (2007), 1218–1226.
-
(2007)
J Am Soc Nephrol
, vol.18
, pp. 1218-1226
-
-
Kojima, I.1
Tanaka, T.2
Inagi, R.3
-
10
-
-
42449163874
-
Somatic inactivation of the PHD2 prolyl hydroxylase causes polycythemia and congestive heart failure
-
Minamishima, Y.A., Moslehi, J., Bardeesy, N., et al. Somatic inactivation of the PHD2 prolyl hydroxylase causes polycythemia and congestive heart failure. Blood 111 (2008), 3236–3244.
-
(2008)
Blood
, vol.111
, pp. 3236-3244
-
-
Minamishima, Y.A.1
Moslehi, J.2
Bardeesy, N.3
-
11
-
-
38049173572
-
A gain-of-function mutation in the HIF2A gene in familial erythrocytosis
-
Percy, M.J., Furlow, P.W., Lucas, G.S., et al. A gain-of-function mutation in the HIF2A gene in familial erythrocytosis. N Engl J Med 358 (2008), 162–168.
-
(2008)
N Engl J Med
, vol.358
, pp. 162-168
-
-
Percy, M.J.1
Furlow, P.W.2
Lucas, G.S.3
-
12
-
-
31444436640
-
A family with erythrocytosis establishes a role for prolyl hydroxylase domain protein 2 in oxygen homeostasis
-
Percy, M.J., Zhao, Q., Flores, A., et al. A family with erythrocytosis establishes a role for prolyl hydroxylase domain protein 2 in oxygen homeostasis. Proc Natl Acad Sci U S A 103 (2006), 654–659.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 654-659
-
-
Percy, M.J.1
Zhao, Q.2
Flores, A.3
-
13
-
-
85021195196
-
Prolyl hydroxylase domain inhibitors as a novel therapeutic approach against anemia in chronic kidney disease
-
Sugahara, M., Tanaka, T., Nangaku, M., Prolyl hydroxylase domain inhibitors as a novel therapeutic approach against anemia in chronic kidney disease. Kidney Int 92 (2017), 306–312.
-
(2017)
Kidney Int
, vol.92
, pp. 306-312
-
-
Sugahara, M.1
Tanaka, T.2
Nangaku, M.3
-
14
-
-
84878347460
-
Cardiovascular toxicity of epoetin-alfa in patients with chronic kidney disease
-
McCullough, P.A., Barnhart, H.X., Inrig, J.K., et al. Cardiovascular toxicity of epoetin-alfa in patients with chronic kidney disease. Am J Nephrol 37 (2013), 549–558.
-
(2013)
Am J Nephrol
, vol.37
, pp. 549-558
-
-
McCullough, P.A.1
Barnhart, H.X.2
Inrig, J.K.3
-
15
-
-
33751002326
-
Normalization of hemoglobin level in patients with chronic kidney disease and anemia
-
Drueke, T.B., Locatelli, F., Clyne, N., et al. Normalization of hemoglobin level in patients with chronic kidney disease and anemia. N Engl J Med 355 (2006), 2071–2084.
-
(2006)
N Engl J Med
, vol.355
, pp. 2071-2084
-
-
Drueke, T.B.1
Locatelli, F.2
Clyne, N.3
-
16
-
-
33750983605
-
Correction of anemia with epoetin alfa in chronic kidney disease
-
Singh, A.K., Szczech, L., Tang, K.L., et al. Correction of anemia with epoetin alfa in chronic kidney disease. N Engl J Med 355 (2006), 2085–2098.
-
(2006)
N Engl J Med
, vol.355
, pp. 2085-2098
-
-
Singh, A.K.1
Szczech, L.2
Tang, K.L.3
-
17
-
-
70949108082
-
A trial of darbepoetin alfa in type 2 diabetes and chronic kidney disease
-
Pfeffer, M.A., Burdmann, E.A., Chen, C.Y., et al. A trial of darbepoetin alfa in type 2 diabetes and chronic kidney disease. N Engl J Med 361 (2009), 2019–2032.
-
(2009)
N Engl J Med
, vol.361
, pp. 2019-2032
-
-
Pfeffer, M.A.1
Burdmann, E.A.2
Chen, C.Y.3
-
18
-
-
84884333035
-
KDIGO Clinical Practice Guideline for anemia in chronic kidney disease
-
KDIGO Clinical Practice Guideline for anemia in chronic kidney disease. Kidney Int Suppl 2 (2012), 279–335.
-
(2012)
Kidney Int Suppl
, vol.2
, pp. 279-335
-
-
-
19
-
-
28244446238
-
Hypoxia-inducible factor 1-alpha reduces infarction and attenuates progression of cardiac dysfunction after myocardial infarction in the mouse
-
Kido, M., Du, L., Sullivan, C.C., et al. Hypoxia-inducible factor 1-alpha reduces infarction and attenuates progression of cardiac dysfunction after myocardial infarction in the mouse. J Am Coll Cardiol 46 (2005), 2116–2124.
-
(2005)
J Am Coll Cardiol
, vol.46
, pp. 2116-2124
-
-
Kido, M.1
Du, L.2
Sullivan, C.C.3
-
20
-
-
47649128513
-
Hypoxia-inducible factor-1 is central to cardioprotection: a new paradigm for ischemic preconditioning
-
Eckle, T., Kohler, D., Lehmann, R., et al. Hypoxia-inducible factor-1 is central to cardioprotection: a new paradigm for ischemic preconditioning. Circulation 118 (2008), 166–175.
-
(2008)
Circulation
, vol.118
, pp. 166-175
-
-
Eckle, T.1
Kohler, D.2
Lehmann, R.3
-
21
-
-
79953179377
-
Cardiomyocyte-specific prolyl-4-hydroxylase domain 2 knock out protects from acute myocardial ischemic injury
-
Holscher, M., Silter, M., Krull, S., et al. Cardiomyocyte-specific prolyl-4-hydroxylase domain 2 knock out protects from acute myocardial ischemic injury. J Biol Chem 286 (2011), 11185–11194.
-
(2011)
J Biol Chem
, vol.286
, pp. 11185-11194
-
-
Holscher, M.1
Silter, M.2
Krull, S.3
-
22
-
-
77951552411
-
Hearts of hypoxia-inducible factor prolyl 4-hydroxylase-2 hypomorphic mice show protection against acute ischemia-reperfusion injury
-
Hyvarinen, J., Hassinen, I.E., Sormunen, R., et al. Hearts of hypoxia-inducible factor prolyl 4-hydroxylase-2 hypomorphic mice show protection against acute ischemia-reperfusion injury. J Biol Chem 285 (2010), 13646–13657.
-
(2010)
J Biol Chem
, vol.285
, pp. 13646-13657
-
-
Hyvarinen, J.1
Hassinen, I.E.2
Sormunen, R.3
-
23
-
-
84941357822
-
Pre- and post-conditional inhibition of prolyl-4-hydroxylase domain enzymes protects the heart from an ischemic insult
-
Vogler, M., Zieseniss, A., Hesse, A.R., et al. Pre- and post-conditional inhibition of prolyl-4-hydroxylase domain enzymes protects the heart from an ischemic insult. Pflugers Arch 467 (2015), 2141–2149.
-
(2015)
Pflugers Arch
, vol.467
, pp. 2141-2149
-
-
Vogler, M.1
Zieseniss, A.2
Hesse, A.R.3
-
24
-
-
77957254118
-
Loss of hypoxia-inducible factor prolyl hydroxylase activity in cardiomyocytes phenocopies ischemic cardiomyopathy
-
Moslehi, J., Minamishima, Y.A., Shi, J., et al. Loss of hypoxia-inducible factor prolyl hydroxylase activity in cardiomyocytes phenocopies ischemic cardiomyopathy. Circulation 122 (2010), 1004–1016.
-
(2010)
Circulation
, vol.122
, pp. 1004-1016
-
-
Moslehi, J.1
Minamishima, Y.A.2
Shi, J.3
-
25
-
-
43649100536
-
Hypoxia-inducible factor-dependent degeneration, failure, and malignant transformation of the heart in the absence of the von Hippel-Lindau protein
-
Lei, L., Mason, S., Liu, D., et al. Hypoxia-inducible factor-dependent degeneration, failure, and malignant transformation of the heart in the absence of the von Hippel-Lindau protein. Mol Cell Biol 28 (2008), 3790–3803.
-
(2008)
Mol Cell Biol
, vol.28
, pp. 3790-3803
-
-
Lei, L.1
Mason, S.2
Liu, D.3
-
26
-
-
66049097308
-
Activation of a HIF1alpha-PPARgamma axis underlies the integration of glycolytic and lipid anabolic pathways in pathologic cardiac hypertrophy
-
Krishnan, J., Suter, M., Windak, R., et al. Activation of a HIF1alpha-PPARgamma axis underlies the integration of glycolytic and lipid anabolic pathways in pathologic cardiac hypertrophy. Cell Metab 9 (2009), 512–524.
-
(2009)
Cell Metab
, vol.9
, pp. 512-524
-
-
Krishnan, J.1
Suter, M.2
Windak, R.3
-
27
-
-
33947520124
-
p53-induced inhibition of Hif-1 causes cardiac dysfunction during pressure overload
-
Sano, M., Minamino, T., Toko, H., et al. p53-induced inhibition of Hif-1 causes cardiac dysfunction during pressure overload. Nature 446 (2007), 444–448.
-
(2007)
Nature
, vol.446
, pp. 444-448
-
-
Sano, M.1
Minamino, T.2
Toko, H.3
-
28
-
-
84859469406
-
Endothelial expression of hypoxia-inducible factor 1 protects the murine heart and aorta from pressure overload by suppression of TGF-beta signaling
-
Wei, H., Bedja, D., Koitabashi, N., et al. Endothelial expression of hypoxia-inducible factor 1 protects the murine heart and aorta from pressure overload by suppression of TGF-beta signaling. Proc Natl Acad Sci U S A 109 (2012), E841–E850.
-
(2012)
Proc Natl Acad Sci U S A
, vol.109
, pp. E841-E850
-
-
Wei, H.1
Bedja, D.2
Koitabashi, N.3
-
29
-
-
0025286817
-
Elevated circulating levels of tumor necrosis factor in severe chronic heart failure
-
Levine, B., Kalman, J., Mayer, L., et al. Elevated circulating levels of tumor necrosis factor in severe chronic heart failure. N Engl J Med 323 (1990), 236–241.
-
(1990)
N Engl J Med
, vol.323
, pp. 236-241
-
-
Levine, B.1
Kalman, J.2
Mayer, L.3
-
30
-
-
0034687595
-
Plasma cytokine parameters and mortality in patients with chronic heart failure
-
Rauchhaus, M., Doehner, W., Francis, D.P., et al. Plasma cytokine parameters and mortality in patients with chronic heart failure. Circulation 102 (2000), 3060–3067.
-
(2000)
Circulation
, vol.102
, pp. 3060-3067
-
-
Rauchhaus, M.1
Doehner, W.2
Francis, D.P.3
-
31
-
-
36549033197
-
The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions
-
Nahrendorf, M., Swirski, F.K., Aikawa, E., et al. The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions. J Exp Med 204 (2007), 3037–3047.
-
(2007)
J Exp Med
, vol.204
, pp. 3037-3047
-
-
Nahrendorf, M.1
Swirski, F.K.2
Aikawa, E.3
-
32
-
-
0028786601
-
A hypoxia-responsive element mediates a novel pathway of activation of the inducible nitric oxide synthase promoter
-
Melillo, G., Musso, T., Sica, A., et al. A hypoxia-responsive element mediates a novel pathway of activation of the inducible nitric oxide synthase promoter. J Exp Med 182 (1995), 1683–1693.
-
(1995)
J Exp Med
, vol.182
, pp. 1683-1693
-
-
Melillo, G.1
Musso, T.2
Sica, A.3
-
33
-
-
84970028181
-
HIF-1alpha-PDK1 axis-induced active glycolysis plays an essential role in macrophage migratory capacity
-
Semba, H., Takeda, N., Isagawa, T., et al. HIF-1alpha-PDK1 axis-induced active glycolysis plays an essential role in macrophage migratory capacity. Nat Commun, 7, 2016, 11635.
-
(2016)
Nat Commun
, vol.7
, pp. 11635
-
-
Semba, H.1
Takeda, N.2
Isagawa, T.3
-
34
-
-
0037423948
-
HIF-1alpha is essential for myeloid cell-mediated inflammation
-
Cramer, T., Yamanishi, Y., Clausen, B.E., et al. HIF-1alpha is essential for myeloid cell-mediated inflammation. Cell 112 (2003), 645–657.
-
(2003)
Cell
, vol.112
, pp. 645-657
-
-
Cramer, T.1
Yamanishi, Y.2
Clausen, B.E.3
-
35
-
-
85028944616
-
Prolyl hydroxylase 2 inactivation enhances glycogen storage and promotes excessive neutrophilic responses
-
Sadiku, P., Willson, J.A., Dickinson, R.S., et al. Prolyl hydroxylase 2 inactivation enhances glycogen storage and promotes excessive neutrophilic responses. J Clin Invest 127 (2017), 3407–3420.
-
(2017)
J Clin Invest
, vol.127
, pp. 3407-3420
-
-
Sadiku, P.1
Willson, J.A.2
Dickinson, R.S.3
-
36
-
-
79958724181
-
Fibroblast growth factor 23 and risks of mortality and end-stage renal disease in patients with chronic kidney disease
-
Isakova, T., Xie, H., Yang, W., et al. Fibroblast growth factor 23 and risks of mortality and end-stage renal disease in patients with chronic kidney disease. JAMA 305 (2011), 2432–2439.
-
(2011)
JAMA
, vol.305
, pp. 2432-2439
-
-
Isakova, T.1
Xie, H.2
Yang, W.3
-
37
-
-
85020295627
-
Fibroblast growth factor 23: mineral metabolism and beyond
-
Grabner, A., Mazzaferro, S., Cianciolo, G., et al. Fibroblast growth factor 23: mineral metabolism and beyond. Contrib Nephrol 190 (2017), 83–95.
-
(2017)
Contrib Nephrol
, vol.190
, pp. 83-95
-
-
Grabner, A.1
Mazzaferro, S.2
Cianciolo, G.3
-
38
-
-
80555148939
-
FGF23 induces left ventricular hypertrophy
-
Faul, C., Amaral, A.P., Oskouei, B., et al. FGF23 induces left ventricular hypertrophy. J Clin Invest 121 (2011), 4393–4408.
-
(2011)
J Clin Invest
, vol.121
, pp. 4393-4408
-
-
Faul, C.1
Amaral, A.P.2
Oskouei, B.3
-
39
-
-
84945942478
-
Activation of cardiac fibroblast growth factor receptor 4 causes left ventricular hypertrophy
-
Grabner, A., Amaral, A.P., Schramm, K., et al. Activation of cardiac fibroblast growth factor receptor 4 causes left ventricular hypertrophy. Cell Metab 22 (2015), 1020–1032.
-
(2015)
Cell Metab
, vol.22
, pp. 1020-1032
-
-
Grabner, A.1
Amaral, A.P.2
Schramm, K.3
-
40
-
-
84946130633
-
Inflammation and functional iron deficiency regulate fibroblast growth factor 23 production
-
David, V., Martin, A., Isakova, T., et al. Inflammation and functional iron deficiency regulate fibroblast growth factor 23 production. Kidney Int 89 (2016), 135–146.
-
(2016)
Kidney Int
, vol.89
, pp. 135-146
-
-
David, V.1
Martin, A.2
Isakova, T.3
-
41
-
-
85032445513
-
FGF23 expression in rodents is directly induced via erythropoietin after inhibition of hypoxia inducible factor proline hydroxylase
-
Flamme, I., Ellinghaus, P., Urrego, D., et al. FGF23 expression in rodents is directly induced via erythropoietin after inhibition of hypoxia inducible factor proline hydroxylase. PLoS One, 12, 2017, e0186979.
-
(2017)
PLoS One
, vol.12
, pp. e0186979
-
-
Flamme, I.1
Ellinghaus, P.2
Urrego, D.3
-
42
-
-
85019043941
-
High fibroblast growth factor 23 levels are associated with decreased ferritin levels and increased intravenous iron doses in hemodialysis patients
-
Honda, H., Michihata, T., Shishido, K., et al. High fibroblast growth factor 23 levels are associated with decreased ferritin levels and increased intravenous iron doses in hemodialysis patients. PLoS One, 12, 2017, e0176984.
-
(2017)
PLoS One
, vol.12
, pp. e0176984
-
-
Honda, H.1
Michihata, T.2
Shishido, K.3
-
43
-
-
0001507064
-
The terminal portion of the pulmonary arterial tree in people native to high altitudes
-
Arias-Stella, J., Saldana, M., The terminal portion of the pulmonary arterial tree in people native to high altitudes. Circulation 28 (1963), 915–925.
-
(1963)
Circulation
, vol.28
, pp. 915-925
-
-
Arias-Stella, J.1
Saldana, M.2
-
44
-
-
50949133897
-
Autosomal dominant erythrocytosis and pulmonary arterial hypertension associated with an activating HIF2 alpha mutation
-
Gale, D.P., Harten, S.K., Reid, C.D., et al. Autosomal dominant erythrocytosis and pulmonary arterial hypertension associated with an activating HIF2 alpha mutation. Blood 112 (2008), 919–921.
-
(2008)
Blood
, vol.112
, pp. 919-921
-
-
Gale, D.P.1
Harten, S.K.2
Reid, C.D.3
-
45
-
-
85017532095
-
Cardiopulmonary phenotype associated with human PHD2 mutation
-
Talbot, N.P., Smith, T.G., Balanos, G.M., et al. Cardiopulmonary phenotype associated with human PHD2 mutation. Physiol Rep, 5, 2017, 7.
-
(2017)
Physiol Rep
, vol.5
, pp. 7
-
-
Talbot, N.P.1
Smith, T.G.2
Balanos, G.M.3
-
46
-
-
33746398489
-
Mutation of von Hippel-Lindau tumour suppressor and human cardiopulmonary physiology
-
Smith, T.G., Brooks, J.T., Balanos, G.M., et al. Mutation of von Hippel-Lindau tumour suppressor and human cardiopulmonary physiology. PLoS Med, 3, 2006, e290.
-
(2006)
PLoS Med
, vol.3
, pp. e290
-
-
Smith, T.G.1
Brooks, J.T.2
Balanos, G.M.3
-
47
-
-
84922391897
-
A genetic mechanism for Tibetan high-altitude adaptation
-
Lorenzo, F.R., Huff, C., Myllymaki, M., et al. A genetic mechanism for Tibetan high-altitude adaptation. Nat Genet 46 (2014), 951–956.
-
(2014)
Nat Genet
, vol.46
, pp. 951-956
-
-
Lorenzo, F.R.1
Huff, C.2
Myllymaki, M.3
-
48
-
-
84901217970
-
Tibetans living at sea level have a hyporesponsive hypoxia-inducible factor system and blunted physiological responses to hypoxia
-
Petousi, N., Croft, Q.P., Cavalleri, G.L., et al. Tibetans living at sea level have a hyporesponsive hypoxia-inducible factor system and blunted physiological responses to hypoxia. J Appl Physiol 116 (1985), 893–904.
-
(1985)
J Appl Physiol
, vol.116
, pp. 893-904
-
-
Petousi, N.1
Croft, Q.P.2
Cavalleri, G.L.3
-
49
-
-
85047691081
-
Heterozygous deficiency of hypoxia-inducible factor-2alpha protects mice against pulmonary hypertension and right ventricular dysfunction during prolonged hypoxia
-
Brusselmans, K., Compernolle, V., Tjwa, M., et al. Heterozygous deficiency of hypoxia-inducible factor-2alpha protects mice against pulmonary hypertension and right ventricular dysfunction during prolonged hypoxia. J Clin Invest 111 (2003), 1519–1527.
-
(2003)
J Clin Invest
, vol.111
, pp. 1519-1527
-
-
Brusselmans, K.1
Compernolle, V.2
Tjwa, M.3
-
50
-
-
84982671719
-
HIF2alpha-arginase axis is essential for the development of pulmonary hypertension
-
Cowburn, A.S., Crosby, A., Macias, D., et al. HIF2alpha-arginase axis is essential for the development of pulmonary hypertension. Proc Natl Acad Sci U S A 113 (2016), 8801–8806.
-
(2016)
Proc Natl Acad Sci U S A
, vol.113
, pp. 8801-8806
-
-
Cowburn, A.S.1
Crosby, A.2
Macias, D.3
-
51
-
-
84879037862
-
Erythrocytosis and pulmonary hypertension in a mouse model of human HIF2A gain of function mutation
-
Tan, Q., Kerestes, H., Percy, M.J., et al. Erythrocytosis and pulmonary hypertension in a mouse model of human HIF2A gain of function mutation. J Biol Chem 288 (2013), 17134–17144.
-
(2013)
J Biol Chem
, vol.288
, pp. 17134-17144
-
-
Tan, Q.1
Kerestes, H.2
Percy, M.J.3
-
52
-
-
84875227009
-
Pulmonary hypertension in CKD
-
Bolignano, D., Rastelli, S., Agarwal, R., et al. Pulmonary hypertension in CKD. Am J Kidney Dis 61 (2013), 612–622.
-
(2013)
Am J Kidney Dis
, vol.61
, pp. 612-622
-
-
Bolignano, D.1
Rastelli, S.2
Agarwal, R.3
-
54
-
-
40849086607
-
Hypoxia, hypoxia-inducible transcription factor, and macrophages in human atherosclerotic plaques are correlated with intraplaque angiogenesis
-
Sluimer, J.C., Gasc, J.M., van Wanroij, J.L., et al. Hypoxia, hypoxia-inducible transcription factor, and macrophages in human atherosclerotic plaques are correlated with intraplaque angiogenesis. J Am Coll Cardiol 51 (2008), 1258–1265.
-
(2008)
J Am Coll Cardiol
, vol.51
, pp. 1258-1265
-
-
Sluimer, J.C.1
Gasc, J.M.2
van Wanroij, J.L.3
-
55
-
-
84945477011
-
Deficiency of HIF1alpha in antigen-presenting cells aggravates atherosclerosis and type 1 T-helper cell responses in mice
-
Chaudhari, S.M., Sluimer, J.C., Koch, M., et al. Deficiency of HIF1alpha in antigen-presenting cells aggravates atherosclerosis and type 1 T-helper cell responses in mice. Arterioscler Thromb Vasc Biol 35 (2015), 2316–2325.
-
(2015)
Arterioscler Thromb Vasc Biol
, vol.35
, pp. 2316-2325
-
-
Chaudhari, S.M.1
Sluimer, J.C.2
Koch, M.3
-
56
-
-
84979662970
-
Hypoxia-inducible factor-1alpha expression in macrophages promotes development of atherosclerosis
-
Aarup, A., Pedersen, T.X., Junker, N., et al. Hypoxia-inducible factor-1alpha expression in macrophages promotes development of atherosclerosis. Arterioscler Thromb Vasc Biol 36 (2016), 1782–1790.
-
(2016)
Arterioscler Thromb Vasc Biol
, vol.36
, pp. 1782-1790
-
-
Aarup, A.1
Pedersen, T.X.2
Junker, N.3
-
57
-
-
0032528913
-
Identification of the lectin-like receptor for oxidized low-density lipoprotein in human macrophages and its potential role as a scavenger receptor
-
Yoshida, H., Kondratenko, N., Green, S., et al. Identification of the lectin-like receptor for oxidized low-density lipoprotein in human macrophages and its potential role as a scavenger receptor. Biochem J 334 (1998), 9–13.
-
(1998)
Biochem J
, vol.334
, pp. 9-13
-
-
Yoshida, H.1
Kondratenko, N.2
Green, S.3
-
58
-
-
84879421653
-
Hypoxia enhances lipid uptake in macrophages: role of the scavenger receptors Lox1, SRA, and CD36
-
Crucet, M., Wust, S.J., Spielmann, P., et al. Hypoxia enhances lipid uptake in macrophages: role of the scavenger receptors Lox1, SRA, and CD36. Atherosclerosis 229 (2013), 110–117.
-
(2013)
Atherosclerosis
, vol.229
, pp. 110-117
-
-
Crucet, M.1
Wust, S.J.2
Spielmann, P.3
-
59
-
-
0035993485
-
LOX-1, the receptor for oxidized low-density lipoprotein identified from endothelial cells: implications in endothelial dysfunction and atherosclerosis
-
Chen, M., Masaki, T., Sawamura, T., LOX-1, the receptor for oxidized low-density lipoprotein identified from endothelial cells: implications in endothelial dysfunction and atherosclerosis. Pharmacol Ther 95 (2002), 89–100.
-
(2002)
Pharmacol Ther
, vol.95
, pp. 89-100
-
-
Chen, M.1
Masaki, T.2
Sawamura, T.3
-
60
-
-
3042734510
-
Decreased number and impaired angiogenic function of endothelial progenitor cells in patients with chronic renal failure
-
Choi, J.H., Kim, K.L., Huh, W., et al. Decreased number and impaired angiogenic function of endothelial progenitor cells in patients with chronic renal failure. Arterioscler Thromb Vasc Biol 24 (2004), 1246–1252.
-
(2004)
Arterioscler Thromb Vasc Biol
, vol.24
, pp. 1246-1252
-
-
Choi, J.H.1
Kim, K.L.2
Huh, W.3
-
61
-
-
70349895636
-
The soluble VEGF receptor sFlt1 contributes to endothelial dysfunction in CKD
-
Di Marco, G.S., Reuter, S., Hillebrand, U., et al. The soluble VEGF receptor sFlt1 contributes to endothelial dysfunction in CKD. J Am Soc Nephrol 20 (2009), 2235–2245.
-
(2009)
J Am Soc Nephrol
, vol.20
, pp. 2235-2245
-
-
Di Marco, G.S.1
Reuter, S.2
Hillebrand, U.3
-
62
-
-
85008319247
-
Hypoxia inducible factor stabilization improves defective ischemia-induced angiogenesis in a rodent model of chronic kidney disease
-
Schellinger, I.N., Cordasic, N., Panesar, J., et al. Hypoxia inducible factor stabilization improves defective ischemia-induced angiogenesis in a rodent model of chronic kidney disease. Kidney Int 91 (2017), 616–627.
-
(2017)
Kidney Int
, vol.91
, pp. 616-627
-
-
Schellinger, I.N.1
Cordasic, N.2
Panesar, J.3
-
63
-
-
84973320456
-
Oral hypoxia-inducible factor prolyl hydroxylase inhibitor roxadustat (FG-4592) for the treatment of anemia in patients with CKD
-
Provenzano, R., Besarab, A., Sun, C.H., et al. Oral hypoxia-inducible factor prolyl hydroxylase inhibitor roxadustat (FG-4592) for the treatment of anemia in patients with CKD. Clin J Am Soc Nephrol 11 (2016), 982–991.
-
(2016)
Clin J Am Soc Nephrol
, vol.11
, pp. 982-991
-
-
Provenzano, R.1
Besarab, A.2
Sun, C.H.3
-
64
-
-
84956633361
-
Roxadustat (FG-4592) versus epoetin alfa for anemia in patients receiving maintenance hemodialysis: a phase 2, randomized, 6- to 19-week, open-label, active-comparator, dose-ranging, safety and exploratory efficacy study
-
Provenzano, R., Besarab, A., Wright, S., et al. Roxadustat (FG-4592) versus epoetin alfa for anemia in patients receiving maintenance hemodialysis: a phase 2, randomized, 6- to 19-week, open-label, active-comparator, dose-ranging, safety and exploratory efficacy study. Am J Kidney Dis 67 (2016), 912–924.
-
(2016)
Am J Kidney Dis
, vol.67
, pp. 912-924
-
-
Provenzano, R.1
Besarab, A.2
Wright, S.3
-
65
-
-
85008384570
-
Effects of daprodustat, a novel hypoxia-inducible factor prolyl hydroxylase inhibitor on anemia management in Japanese hemodialysis subjects
-
Akizawa, T., Tsubakihara, Y., Nangaku, M., et al. Effects of daprodustat, a novel hypoxia-inducible factor prolyl hydroxylase inhibitor on anemia management in Japanese hemodialysis subjects. Am J Nephrol 45 (2017), 127–135.
-
(2017)
Am J Nephrol
, vol.45
, pp. 127-135
-
-
Akizawa, T.1
Tsubakihara, Y.2
Nangaku, M.3
-
66
-
-
85016641947
-
Clinical trial of vadadustat in patients with anemia secondary to stage 3 or 4 chronic kidney disease
-
Martin, E.R., Smith, M.T., Maroni, B.J., et al. Clinical trial of vadadustat in patients with anemia secondary to stage 3 or 4 chronic kidney disease. Am J Nephrol 45 (2017), 380–388.
-
(2017)
Am J Nephrol
, vol.45
, pp. 380-388
-
-
Martin, E.R.1
Smith, M.T.2
Maroni, B.J.3
-
67
-
-
84907481900
-
HIF prolyl 4-hydroxylase-2 inhibition improves glucose and lipid metabolism and protects against obesity and metabolic dysfunction
-
Rahtu-Korpela, L., Karsikas, S., Horkko, S., et al. HIF prolyl 4-hydroxylase-2 inhibition improves glucose and lipid metabolism and protects against obesity and metabolic dysfunction. Diabetes 63 (2014), 3324–3333.
-
(2014)
Diabetes
, vol.63
, pp. 3324-3333
-
-
Rahtu-Korpela, L.1
Karsikas, S.2
Horkko, S.3
-
68
-
-
84878313576
-
Prolyl hydroxylase domain protein 2 plays a critical role in diet-induced obesity and glucose intolerance
-
Matsuura, H., Ichiki, T., Inoue, E., et al. Prolyl hydroxylase domain protein 2 plays a critical role in diet-induced obesity and glucose intolerance. Circulation 127 (2013), 2078–2087.
-
(2013)
Circulation
, vol.127
, pp. 2078-2087
-
-
Matsuura, H.1
Ichiki, T.2
Inoue, E.3
-
69
-
-
85020299178
-
Hypoxia-inducible factor 1alpha activates insulin-induced gene 2 (Insig-2) transcription for degradation of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase in the liver
-
Hwang, S., Nguyen, A.D., Jo, Y., et al. Hypoxia-inducible factor 1alpha activates insulin-induced gene 2 (Insig-2) transcription for degradation of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase in the liver. J Biol Chem 292 (2017), 9382–9393.
-
(2017)
J Biol Chem
, vol.292
, pp. 9382-9393
-
-
Hwang, S.1
Nguyen, A.D.2
Jo, Y.3
-
70
-
-
84994336731
-
Deficiency of the oxygen sensor prolyl hydroxylase 1 attenuates hypercholesterolaemia, atherosclerosis, and hyperglycaemia
-
Marsch, E., Demandt, J.A., Theelen, T.L., et al. Deficiency of the oxygen sensor prolyl hydroxylase 1 attenuates hypercholesterolaemia, atherosclerosis, and hyperglycaemia. Eur Heart J 37 (2016), 2993–2997.
-
(2016)
Eur Heart J
, vol.37
, pp. 2993-2997
-
-
Marsch, E.1
Demandt, J.A.2
Theelen, T.L.3
-
71
-
-
85016925358
-
Roxadustat (FG-4592): correction of anemia in incident dialysis patients
-
Besarab, A., Chernyavskaya, E., Motylev, I., et al. Roxadustat (FG-4592): correction of anemia in incident dialysis patients. J Am Soc Nephrol 27 (2016), 1225–1233.
-
(2016)
J Am Soc Nephrol
, vol.27
, pp. 1225-1233
-
-
Besarab, A.1
Chernyavskaya, E.2
Motylev, I.3
-
72
-
-
84994143390
-
Vadadustat, a novel oral HIF stabilizer, provides effective anemia treatment in nondialysis-dependent chronic kidney disease
-
Pergola, P.E., Spinowitz, B.S., Hartman, C.S., et al. Vadadustat, a novel oral HIF stabilizer, provides effective anemia treatment in nondialysis-dependent chronic kidney disease. Kidney Int 90 (2016), 1115–1122.
-
(2016)
Kidney Int
, vol.90
, pp. 1115-1122
-
-
Pergola, P.E.1
Spinowitz, B.S.2
Hartman, C.S.3
-
73
-
-
0034919301
-
Novel erythropoiesis stimulating protein for treatment of anemia in chronic renal insufficiency
-
Locatelli, F., Olivares, J., Walker, R., et al. Novel erythropoiesis stimulating protein for treatment of anemia in chronic renal insufficiency. Kidney Int 60 (2001), 741–747.
-
(2001)
Kidney Int
, vol.60
, pp. 741-747
-
-
Locatelli, F.1
Olivares, J.2
Walker, R.3
-
74
-
-
84911895497
-
Mimicking hypoxia to treat anemia: HIF-stabilizer BAY 85-3934 (Molidustat) stimulates erythropoietin production without hypertensive effects
-
Flamme, I., Oehme, F., Ellinghaus, P., et al. Mimicking hypoxia to treat anemia: HIF-stabilizer BAY 85-3934 (Molidustat) stimulates erythropoietin production without hypertensive effects. PLoS One, 9, 2014, e111838.
-
(2014)
PLoS One
, vol.9
, pp. e111838
-
-
Flamme, I.1
Oehme, F.2
Ellinghaus, P.3
-
75
-
-
84886414629
-
HIF isoforms in the skin differentially regulate systemic arterial pressure
-
Cowburn, A.S., Takeda, N., Boutin, A.T., et al. HIF isoforms in the skin differentially regulate systemic arterial pressure. Proc Natl Acad Sci U S A 110 (2013), 17570–17575.
-
(2013)
Proc Natl Acad Sci U S A
, vol.110
, pp. 17570-17575
-
-
Cowburn, A.S.1
Takeda, N.2
Boutin, A.T.3
-
76
-
-
77649177217
-
Differential activation and antagonistic function of HIF-{alpha} isoforms in macrophages are essential for NO homeostasis
-
Takeda, N., O'Dea, E.L., Doedens, A., et al. Differential activation and antagonistic function of HIF-{alpha} isoforms in macrophages are essential for NO homeostasis. Genes Dev 24 (2010), 491–501.
-
(2010)
Genes Dev
, vol.24
, pp. 491-501
-
-
Takeda, N.1
O'Dea, E.L.2
Doedens, A.3
-
77
-
-
43249108443
-
Abnormal sympathoadrenal development and systemic hypotension in PHD3-/- mice
-
Bishop, T., Gallagher, D., Pascual, A., et al. Abnormal sympathoadrenal development and systemic hypotension in PHD3-/- mice. Mol Cell Biol 28 (2008), 3386–3400.
-
(2008)
Mol Cell Biol
, vol.28
, pp. 3386-3400
-
-
Bishop, T.1
Gallagher, D.2
Pascual, A.3
-
78
-
-
79952609061
-
Hypoxia-inducible factor 2alpha (HIF-2alpha) heterozygous-null mice exhibit exaggerated carotid body sensitivity to hypoxia, breathing instability, and hypertension
-
Peng, Y.J., Nanduri, J., Khan, S.A., et al. Hypoxia-inducible factor 2alpha (HIF-2alpha) heterozygous-null mice exhibit exaggerated carotid body sensitivity to hypoxia, breathing instability, and hypertension. Proc Natl Acad Sci U S A 108 (2011), 3065–3070.
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, pp. 3065-3070
-
-
Peng, Y.J.1
Nanduri, J.2
Khan, S.A.3
-
79
-
-
77951463662
-
Hypoxia-inducible factor prolyl-hydroxylase 2 senses high-salt intake to increase hypoxia inducible factor 1alpha levels in the renal medulla
-
Wang, Z., Zhu, Q., Xia, M., et al. Hypoxia-inducible factor prolyl-hydroxylase 2 senses high-salt intake to increase hypoxia inducible factor 1alpha levels in the renal medulla. Hypertension 55 (2010), 1129–1136.
-
(2010)
Hypertension
, vol.55
, pp. 1129-1136
-
-
Wang, Z.1
Zhu, Q.2
Xia, M.3
-
80
-
-
84859042920
-
Overexpression of HIF-1alpha transgene in the renal medulla attenuated salt sensitive hypertension in Dahl S rats
-
Zhu, Q., Wang, Z., Xia, M., et al. Overexpression of HIF-1alpha transgene in the renal medulla attenuated salt sensitive hypertension in Dahl S rats. Biochim Biophys Acta 1822 (2012), 936–941.
-
(2012)
Biochim Biophys Acta
, vol.1822
, pp. 936-941
-
-
Zhu, Q.1
Wang, Z.2
Xia, M.3
-
81
-
-
84890505292
-
Silencing of HIF prolyl-hydroxylase 2 gene in the renal medulla attenuates salt-sensitive hypertension in Dahl S rats
-
Zhu, Q., Hu, J., Han, W.Q., et al. Silencing of HIF prolyl-hydroxylase 2 gene in the renal medulla attenuates salt-sensitive hypertension in Dahl S rats. Am J Hypertens 27 (2014), 107–113.
-
(2014)
Am J Hypertens
, vol.27
, pp. 107-113
-
-
Zhu, Q.1
Hu, J.2
Han, W.Q.3
-
82
-
-
84974659924
-
Correction: adipose tissue-derived mesenchymal stem cells in long-term dialysis patients display downregulation of PCAF expression and poor angiogenesis activation
-
Yamanaka, S., Yokote, S., Yamada, A., et al. Correction: adipose tissue-derived mesenchymal stem cells in long-term dialysis patients display downregulation of PCAF expression and poor angiogenesis activation. PLoS One, 11, 2016, e0157282.
-
(2016)
PLoS One
, vol.11
, pp. e0157282
-
-
Yamanaka, S.1
Yokote, S.2
Yamada, A.3
-
83
-
-
84938553872
-
Inflammation and hypoxia linked to renal injury by CCAAT/enhancer-binding protein delta
-
Yamaguchi, J., Tanaka, T., Eto, N., et al. Inflammation and hypoxia linked to renal injury by CCAAT/enhancer-binding protein delta. Kidney Int 88 (2015), 262–275.
-
(2015)
Kidney Int
, vol.88
, pp. 262-275
-
-
Yamaguchi, J.1
Tanaka, T.2
Eto, N.3
|