HIF2α-Arginase axis is essential for the development of pulmonary hypertension

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 31, 2016, Pages 8801-8806

  Cowburn, Andrew S ^a   Crosby, Alexi ^a   Macias, David ^a   Branco, Cristina ^a   Colaço, Renato D D R ^a   Southwood, Mark ^b   Toshner, Mark ^a   Alexander, Laura E Crotty ^a   Morrell, Nicholas W ^c   Chilvers, Edwin R ^d   Johnson, Randall S ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b PAPWORTH HOSPITAL   (United Kingdom)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVIN RECEPTOR LIKE KINASE 1; ALPHA SMOOTH MUSCLE ACTIN; ARGINASE; ARGINASE 1; ARGINASE 2; CRE RECOMBINASE; ELASTIN; ENDOTHELIN 1; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 2ALPHA; INDUCIBLE NITRIC OXIDE SYNTHASE; MESSENGER RNA; NITRIC OXIDE; PLATELET DERIVED GROWTH FACTOR B; UNCLASSIFIED DRUG; ARG1 PROTEIN, MOUSE; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; ENDOTHELIAL PAS DOMAIN-CONTAINING PROTEIN 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; CONFERENCE PAPER; CONTROLLED STUDY; GENE DELETION; HEART RIGHT VENTRICLE PRESSURE; HYPOXIA; HYPOXIA-INDUCED PULMONARY HYPERTENSION; LUNG BLOOD VESSEL; LUNG ENDOTHELIUM; LUNG VASCULAR RESISTANCE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN STABILITY; SYSTOLIC BLOOD PRESSURE; UPREGULATION; VASCULAR REMODELING; ANIMAL; C57BL MOUSE; CELL CULTURE; CELL HYPOXIA; CYTOLOGY; GENETICS; HEART RIGHT VENTRICLE FUNCTION; HEART VENTRICLE PRESSURE; HUMAN; KNOCKOUT MOUSE; METABOLISM; PHYSIOLOGY; PULMONARY HYPERTENSION; TRANSGENIC MOUSE; VASCULAR ENDOTHELIUM;

ANIMALS; ARGINASE; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CELL HYPOXIA; CELLS, CULTURED; ENDOTHELIUM, VASCULAR; HUMANS; HYPERTENSION, PULMONARY; HYPOXIA; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MALE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; NITRIC OXIDE; VENTRICULAR FUNCTION, RIGHT; VENTRICULAR PRESSURE;

EID: 84982671719     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1602978113     Document Type: Article

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