HIF prolyl 4-hydroxylase-2 inhibition improves glucose and lipid metabolism and protects against obesity and metabolic dysfunction

Diabetes

Volumn 63, Issue 10, 2014, Pages 3324-3333

  Rahtu Korpela, Lea ^a   Karsikas, Sara ^a   Hörkkö, Sohvi ^a,b   Sequeiros, Roberto Blanco ^b   Lammentausta, Eveliina ^b   Mäkelä, Kari A ^a   Herzig, Karl Heinz ^a   Walkinshaw, Gail ^c   Kivirikko, Kari I ^a   Myllyharju, Johanna ^a   Serpi, Raisa ^a   Koivunen, Peppi ^a  

^a UNIVERSITY OF OULU   (Finland)

^b OULU UNIVERSITY HOSPITAL   (Finland)

^c FIBROGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYL COENZYME A; ADIPONECTIN; CHOLESTEROL; ENZYME INHIBITOR; FG 4497; GLUCOSE; GLUCOSE TRANSPORTER; GLYCOLYTIC ENZYME; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 2ALPHA; HYPOXIA INDUCIBLE FACTOR PROLINE DIOXYGENASE; HYPOXIA INDUCIBLE FACTOR PROLINE DIOXYGENASE 2; INSULIN; INSULIN RECEPTOR SUBSTRATE 2; LEPTIN; LIPID; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; PYRUVATE DEHYDROGENASE KINASE; PYRUVATE DEHYDROGENASE KINASE 1; UNCLASSIFIED DRUG; VERY LOW DENSITY LIPOPROTEIN CHOLESTEROL;

ADIPOCYTE; ADIPOSE TISSUE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL SIZE; CHOLESTEROL BLOOD LEVEL; COMPARATIVE STUDY; CONTROLLED STUDY; ENZYME INHIBITION; FATTY ACID SYNTHESIS; FATTY LIVER; GENOTYPE; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; GLUCOSE TOLERANCE; GLYCOLYSIS; HEART; INFLAMMATION; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; INSULIN SENSITIVITY; KIDNEY; LIPID METABOLISM; LIPOGENESIS; LIVER; MACROPHAGE; METABOLIC DISORDER; MOUSE; NONHUMAN; OBESITY; SKELETAL MUSCLE; TISSUE LEVEL; WILD TYPE; ANIMAL; CARBOHYDRATE METABOLISM; DIET; GENETICS; KNOCKOUT MOUSE; METABOLIC SYNDROME X; METABOLISM; PHYSIOLOGY;

ADIPOCYTES; ANIMALS; CARBOHYDRATE METABOLISM; DIET; GLUCOSE; HYPOXIA-INDUCIBLE FACTOR-PROLINE DIOXYGENASES; INFLAMMATION; LIPID METABOLISM; LIVER; METABOLIC SYNDROME X; MICE; MICE, KNOCKOUT; OBESITY;

EID: 84907481900     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db14-0472     Document Type: Article

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