Prolyl hydroxylase 2 inactivation enhances glycogen storage and promotes excessive neutrophilic responses

Journal of Clinical Investigation

Volumn 127, Issue 9, 2017, Pages 3407-3420

  Sadiku, Pranvera ^a,b   Willson, Joseph A ^a   Dickinson, Rebecca S ^a   Murphy, Fiona ^a   Harris, Alison J ^a   Lewis, Amy ^c   Sammut, David ^c   Mirchandani, Ananda S ^a   Ryan, Eilise ^a   Watts, Emily R ^a   Thompson, A A Roger ^c   Marriott, Helen M ^d   Dockrell, David H ^d   Taylor, Cormac T ^e   Schneider, Martin ^f   Maxwell, Patrick H ^g   Chilvers, Edwin R ^g   Mazzone, Massimilliano ^h   Moral, Veronica ^b   Pugh, Chris W ⁱ   Ratcliffe, Peter J ⁱ   Schofield, Christopher J ^j   Ghesquiere, Bart ^b   Carmeliet, Peter ^b   Whyte, Moira K B ^a   Walmsley, Sarah R ^a   more..

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b Vesalius Research Center   (Belgium)

^c Academic Unit of Respiratory Medicine   (United Kingdom)

^d UNIVERSITY OF SHEFFIELD   (United Kingdom)

^e UNIVERSITY COLLEGE DUBLIN   (Ireland)

^f UNIVERSITY OF HEIDELBERG   (Germany)

^g UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^h KU Leuven and University Hospitals Leuven and Leuven Cancer Institute   (Belgium)

ⁱ UNIVERSITY OF OXFORD   (United Kingdom)

^j UNIVERSITY OF OXFORD   (United Kingdom)

more..

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOGEN; HYPOXIA INDUCIBLE FACTOR PROLYL HYDROXYLASE INHIBITOR; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE; EGLN1 PROTEIN, HUMAN; EGLN1 PROTEIN, MOUSE; HYPOXIA INDUCIBLE FACTOR PROLINE DIOXYGENASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL FUNCTION; CELL MOTILITY; CELL SURVIVAL; CONTROLLED STUDY; ENZYME INACTIVATION; GLYCOLYSIS; INFLAMMATION; INNATE IMMUNITY; MOUSE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; STREPTOCOCCUS PNEUMONIA; ACUTE DISEASE; ANIMAL; C57BL MOUSE; COLITIS; CYTOLOGY; HUMAN; IMMUNOLOGY; LEUKOCYTE; LUNG INJURY; LUNG LAVAGE; METABOLISM; PHENOTYPE; PNEUMOCOCCAL INFECTION; SIGNAL TRANSDUCTION;

ACUTE DISEASE; ANIMALS; BRONCHOALVEOLAR LAVAGE; COLITIS; GLYCOGEN; GLYCOLYSIS; HUMANS; HYPOXIA-INDUCIBLE FACTOR-PROLINE DIOXYGENASES; IMMUNITY, INNATE; INFLAMMATION; LEUKOCYTES; LUNG INJURY; MICE; MICE, INBRED C57BL; NEUTROPHILS; PHENOTYPE; PNEUMOCOCCAL INFECTIONS; SIGNAL TRANSDUCTION;

EID: 85028944616     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI90848     Document Type: Article

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