Structure of the nucleotide exchange factor eIF2B reveals mechanism of memory-enhancing molecule

Science

Volumn 359, Issue 6383, 2018, Pages

  Tsai, Jordan C ^a,b   Miller Vedam, Lakshmi E ^b,c   Anand, Aditya A ^a,b   Jaishankar, Priyadarshini ^a   Nguyen, Henry C ^b,c   Renslo, Adam R ^a   Frost, Adam ^b,c   Walter, Peter ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c CHAN ZUCKERBERG BIOHUB   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

RODENTIA;

2-(4-CHLOROPHENOXY)-N-(4-(2-(4-CHLOROPHENOXY)ACETAMIDO)CYCLOHEXYL)ACETAMIDE; ACETAMIDE DERIVATIVE; CYCLOHEXYLAMINE DERIVATIVE; GUANINE NUCLEOTIDE EXCHANGE FACTOR; NOOTROPIC AGENT; RECOMBINANT PROTEIN;

CHEMISTRY; CRYOELECTRON MICROSCOPY; DRUG EFFECT; ESCHERICHIA COLI; GENETICS; HUMAN; MEMORY; MUTATION; PHOSPHORYLATION; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN MULTIMERIZATION; PROTEIN STABILITY; ULTRASTRUCTURE;

ACETAMIDES; CRYOELECTRON MICROSCOPY; CYCLOHEXYLAMINES; ESCHERICHIA COLI; EUKARYOTIC INITIATION FACTOR-2B; HUMANS; MEMORY; MUTATION; NOOTROPIC AGENTS; PHOSPHORYLATION; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN MULTIMERIZATION; PROTEIN STABILITY; RECOMBINANT PROTEINS;

EID: 85044623356     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aaq0939     Document Type: Article

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