Structure-Activity Studies of Bis-O-Arylglycolamides: Inhibitors of the Integrated Stress Response

ChemMedChem

Volumn 11, Issue 8, 2016, Pages 870-880

  Hearn, Brian R ^a   Jaishankar, Priyadarshini ^a   Sidrauski, Carmela ^b   Tsai, Jordan C ^b   Vedantham, Punitha ^a   Fontaine, Shaun D ^a   Walter, Peter ^b   Renslo, Adam R ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

integrated stress response; ISRIB; protein protein interactions; structure activity relationships; unfolded protein response

Indexed keywords

(4 CHLOROPHENYL)METHYL N [4 [2 (4 CHLOROPHENOXY)ACETAMIDO]CYCLOHEXYL]CARBAMATE; (4 CHLOROPHENYL)METHYL N [4 [[[(4 CHLOROPHENYL)METHOXY]CARBONYL]AMINO]CYCLOHEXYL]CARBAMATE; 2 (4 CHLOROPHENOXY) N [4 [2 (4 CHLORO 3 ETHYNYLPHENOXY)ACETAMIDO]CYCLOHEXYL]ACETAMIDE; 2 (4 CHLOROPHENOXY) N [4 [2 (4 CHLOROBENZENESULFINYL)ACETAMIDO]CYCLOHEXYL]ACETAMIDE; 2 (4 CHLOROPHENOXY) N [4 [2 (4 CHLOROPHENOXY)ACETAMIDO]BUT 2 YN 1 YL]ACETAMIDE; 2 (4 CHLOROPHENOXY) N [4 [2 (4 CHLOROPHENOXY)ACETAMIDO]CYCLOHEXYL]PROPANAMIDE; 2 (4 CHLOROPHENOXY) N [4 [2 (4 CHLOROPHENOXY)ETHANIMIDAMIDO]CYCLOHEXYL]ACETAMIDE; 2 (4 CHLOROPHENOXY) N [4 [2 [(4 CHLOROPHENOXY)SULFANYL]ACETAMIDO]CYCLOHEXYL]ACETAMIDE; 2 (4 CHLOROPHENOXY) N [4 [3 (4 CHLOROPHENOXY)PROPANAMIDO]CYCLOHEXYL]PROPANAMIDE; 2 (4 CHLOROPHENOXY) N [4 [[2 (4 CHLOROPHENOXY)ETHYL]AMINO]CYCLOHEXYL]ACETAMIDE; 2 (4 CHLOROPHENOXY) N [4 [[2 (4 CHLOROPHENYL)ACETAMIDO]METHYL]CYCLOHEXYL]ACETAMIDE; 2 (4 ETHYNYLPHENOXY) N [4 [2 (4 CHLOROPHENOXY)ACETAMIDO]CYCLOHEXYL]ACETAMIDE; 2 (4 ETHYNYLPHENOXY) N [4 [2 (4 ETHYNYLPHENOXY)ACETAMIDO]CYCLOHEXYL]ACETAMIDE; 2 (4 IODOPHENOXY) N [4 [2 (4 CHLOROPHENOXY)ACETAMIDO]CYCLOHEXYL]ACETAMIDE; 2 (4 IODOPHENOXY) N [4 [2 (4 IODOPHENOXY)ACETAMIDO]CYCLOHEXYL]ACETAMIDE; 2 (4 METHOXYLPHENOXY) N [4 [2 (4 METHOXYPHENOXY)ACETAMIDO]CYCLOHEXYL]ACETAMIDE; 2 (4 METHOXYLPHENOXY) N [4 [2 (4 METHYLPHENOXY)ACETAMIDO]CYCLOHEXYL]ACETAMIDE; 2 [(4 CHLOROPHENYL)AMINO] N [4 [2 (4 CHLOROPHENOX)ACETAMIDO]CYCLOHEXYL]ACETAMIDE; 4 CHLOROPHENYL N [4 [2 (4 CHLOROPHENOXY)ACETAMIDO]CYCLOHEXYL]METHYL]CARBAMATE; 4 CHLOROPHENYL N [[4 [[(4 CHLOROPHENOXYCARBONYL)AMINO]METHYL]CYCLOHEXYL]METYL]CARBAMATE; ACETAMIDE DERIVATIVE; ACTIVATING TRANSCRIPTION FACTOR 4; ALDEHYDE; BIS O ARYLGLYCOLAMIDE; GUANINE NUCLEOTIDE EXCHANGE FACTOR; INITIATION FACTOR 2ALPHA; MESSENGER RNA; N [4 [2 (4 CHLOROPHENOXY)ACETAMIDO]CYCLOHEXYL] 2 [4 (TRIFLUOROMETHYL)PHENOXY[ACETAMIDE; N [4 [2 (4 TRIFLUOROMETHYL)PHENOXY]ACETAMIDO]CYCLOHEXYL] 2 [4 (TRIFLUOROMETHYL)PHENOXY]ACETAMIDE; PROTEIN INHIBITOR; UNCLASSIFIED DRUG; GLYCOLIC ACID DERIVATIVE; INITIATION FACTOR 2; PROTEIN BINDING;

ARTICLE; ENDOPLASMIC RETICULUM STRESS; HEK293 CELL LINE; HUMAN; HUMAN CELL; LUMINESCENCE; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS; STRUCTURE ACTIVITY RELATION; AGONISTS; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; METABOLISM; PHOSPHORYLATION; PHYSIOLOGICAL STRESS; SYNTHESIS;

DOSE-RESPONSE RELATIONSHIP, DRUG; EUKARYOTIC INITIATION FACTOR-2; GLYCOLATES; HEK293 CELLS; HUMANS; MOLECULAR STRUCTURE; PHOSPHORYLATION; PROTEIN BINDING; STRESS, PHYSIOLOGICAL; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84954553597     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201500483     Document Type: Article

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