Inhibition of the integrated stress response reverses cognitive deficits after traumatic brain injury

Proceedings of the National Academy of Sciences of the United States of America

Volumn 114, Issue 31, 2017, Pages E6420-E6426

  Chou, Austin ^a   Krukowski, Karen ^a,b   Jopson, Timothy ^a   Zhu, Ping Jun ^d   Costa Mattioli, Mauro ^c   Walter, Peter ^a,b   Rosi, Susanna ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c BAYLOR COLLEGE OF MEDICINE   (United States)

^d NONE

Author keywords

Brain trauma; EIF2 ; Hippocampus; Memory deficits; Translational control

Indexed keywords

INITIATION FACTOR 2ALPHA; 2-(4-CHLOROPHENOXY)-N-(4-(2-(4-CHLOROPHENOXY)ACETAMIDO)CYCLOHEXYL)ACETAMIDE; ACETAMIDE DERIVATIVE; CYCLOHEXYLAMINE DERIVATIVE; INITIATION FACTOR 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASSOCIATION; BRAIN CONTUSION; COGNITIVE DEFECT; CONTROLLED STUDY; INHIBITION (PSYCHOLOGY); INTRACELLULAR SIGNALING; LONG TERM POTENTIATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; STRESS; TRAUMATIC BRAIN INJURY; ANIMAL; C57BL MOUSE; DISEASE MODEL; DRUG EFFECT; EPISODIC MEMORY; HIPPOCAMPUS; MAZE TEST; MEMORY DISORDER; METABOLISM; PATHOLOGY; PHOSPHORYLATION; PHYSIOLOGICAL STRESS; PHYSIOLOGY; SPATIAL LEARNING;

ACETAMIDES; ANIMALS; BRAIN INJURIES, TRAUMATIC; COGNITIVE DYSFUNCTION; CYCLOHEXYLAMINES; DISEASE MODELS, ANIMAL; EUKARYOTIC INITIATION FACTOR-2; HIPPOCAMPUS; LONG-TERM POTENTIATION; MALE; MAZE LEARNING; MEMORY DISORDERS; MEMORY, EPISODIC; MICE; MICE, INBRED C57BL; PHOSPHORYLATION; SPATIAL LEARNING; STRESS, PHYSIOLOGICAL;

EID: 85026518794     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1707661114     Document Type: Article

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