Binding of ISRIB reveals a regulatory site in the nucleotide exchange factor eIF2B

Science

Volumn 359, Issue 6383, 2018, Pages 1533-1536

  Zyryanova, Alisa F ^a   Weis, Félix ^a,b,c   Faille, Alexandre ^a,b   Abo Alard, Akeel ^d   Crespillo Casado, Ana ^a   Sekine, Yusuke ^a   Harding, Heather P ^a   Allen, Felicity ^e   Parts, Leopold ^e   Fromont, Christophe ^d   Fischer, Peter M ^d   Warren, Alan J ^a,b,c   Ron, David ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

^d UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^e WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; ARGININE; GENOMIC DNA; GLUTAMINE; GLYCINE; GREEN FLUORESCENT PROTEIN; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; GUANINE NUCLEOTIDE EXCHANGE FACTOR; HEAT SHOCK PROTEIN; HISTIDINE; HISTIDINOL; INITIATION FACTOR 2; ISRIB PROTEIN; LEUCINE; LYSINE; METHIONINE; PHENYLALANINE; SERINE; THREONINE; TRYPTOPHAN; TYROSINE; UNCLASSIFIED DRUG; 2-(4-CHLOROPHENOXY)-N-(4-(2-(4-CHLOROPHENOXY)ACETAMIDO)CYCLOHEXYL)ACETAMIDE; ACETAMIDE DERIVATIVE; CYCLOHEXYLAMINE DERIVATIVE; PROTEIN BINDING;

BRAIN; CELL; CHEMICAL BINDING; IMMUNITY; INHIBITOR; MEMORY; METABOLISM; MUTATION; RODENT;

ALLOSTERISM; AMINO ACID SUBSTITUTION; ARTICLE; CELL METABOLISM; CELL SELECTION; CRISPR-CAS9 SYSTEM; CRYOELECTRON MICROSCOPY; DNA PROTEIN COMPLEX; DRUG BINDING SITE; DRUG DNA BINDING; DRUG SENSITIVITY; EC50; FLUORESCENCE POLARIZATION; GENE SEQUENCE; HELA CELL LINE; HUMAN; HYDROGEN BOND; IN VITRO STUDY; IN VIVO STUDY; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN STRUCTURE; SCHIZOSACCHAROMYCES POMBE; TARGET CELL; WILD TYPE; ANIMAL; CHEMISTRY; DRUG EFFECT; GENETICS; MOUSE; PHOSPHORYLATION; PHYSIOLOGICAL STRESS; PROTEIN CONFORMATION; PROTEIN SYNTHESIS;

EUKARYOTA; MUS;

ACETAMIDES; ANIMALS; CRYOELECTRON MICROSCOPY; CYCLOHEXYLAMINES; EUKARYOTIC INITIATION FACTOR-2B; HELA CELLS; HUMANS; MICE; MUTAGENESIS; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN BIOSYNTHESIS; PROTEIN CONFORMATION; STRESS, PHYSIOLOGICAL;

EID: 85044640883     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aar5129     Document Type: Article

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