Meat and fiber intake and interaction with pattern recognition receptors (TLR1, TLR2, TLR4, and TLR10) in relation to colorectal cancer in a Danish prospective, case-cohort study

American Journal of Clinical Nutrition

Volumn 107, Issue 3, 2018, Pages 465-479

  Kopp, Tine Iskov ^a,b   Vogel, Ulla ^c   Tjonneland, Anne ^b   Andersen, Vibeke ^d,e,f  

^a Rigshospitalet   (Denmark)

^b DANISH CANCER SOCIETY RESEARCH CENTER   (Denmark)

^c NATIONAL RESEARCH CENTRE FOR THE WORKING ENVIRONMENT   (Denmark)

^d Hospital of Southern Jutland   (Denmark)

^e Institute of Regional Health Research Center Sønderjylland   (Denmark)

^f UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

Author keywords

candidate gene; colorectal cancer; gene environment interaction; Toll like receptors; Western style diet

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; TOLL LIKE RECEPTOR 1; TOLL LIKE RECEPTOR 10; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; PATTERN RECOGNITION RECEPTOR; TLR1 PROTEIN, HUMAN; TLR10 PROTEIN, HUMAN; TLR2 PROTEIN, HUMAN; TLR4 PROTEIN, HUMAN;

ADULT; ARTICLE; CANCER DIAGNOSIS; CANCER INCIDENCE; CANCER RISK; CASE CONTROL STUDY; COHORT ANALYSIS; COLORECTAL CANCER; CONTROLLED STUDY; DIETARY FIBER; DISEASE ASSOCIATION; FEMALE; GENE FREQUENCY; GENOTYPE ENVIRONMENT INTERACTION; HUMAN; LIFESTYLE; MAJOR CLINICAL STUDY; MALE; MEAT; PROCESSED MEAT; PROSPECTIVE STUDY; PROTEIN INTERACTION; RANDOMIZED CONTROLLED TRIAL; RED MEAT; SINGLE NUCLEOTIDE POLYMORPHISM; ADMINISTRATION AND DOSAGE; BIOASSAY; BODY MASS; COLORECTAL TUMOR; DENMARK; DIET; FOLLOW UP; GENETICS; METABOLISM; MIDDLE AGED; RISK FACTOR;

BODY MASS INDEX; COLORECTAL NEOPLASMS; DENMARK; DIET; DIETARY FIBER; ENDPOINT DETERMINATION; FEMALE; FOLLOW-UP STUDIES; HUMANS; MALE; MEAT; MIDDLE AGED; NF-KAPPA B; POLYMORPHISM, SINGLE NUCLEOTIDE; PROSPECTIVE STUDIES; RECEPTORS, PATTERN RECOGNITION; RISK FACTORS; TOLL-LIKE RECEPTOR 1; TOLL-LIKE RECEPTOR 10; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4;

EID: 85044229694     PISSN: 00029165     EISSN: 19383207     Source Type: Journal    
DOI: 10.1093/ajcn/nqx011     Document Type: Article

References (100)

1. Lichtenstein P, Holm NV, Verkasalo PK, Iliadou A, Kaprio J, Koskenvuo M, Pukkala E, Skytthe A, Hemminki K. Environmental and heritable factors in the causation of cancer-analyses of cohorts of twins from Sweden, Denmark, and Finland. N Engl J Med 2000;343:78-85.
2. Ferlay J, Soerjomataram I, Ervik M, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D, Bray F. GLOBOCAN 2012 v1.0, Cancer incidence and mortality worldwide: IARC CancerBase No. 11. 2013. Available from: http://globocan.iarc.fr
3. Huxley RR, Ansary-MoghaddamA, Clifton P, CzernichowS, Parr CL, Woodward M. The impact of dietary and lifestyle risk factors on risk of colorectal cancer: a quantitative overview of the epidemiological evidence. Int J Cancer 2009;125:171-80.
4. Durko L, Malecka-Panas E. Lifestyle modifications and colorectal cancer. Curr Colorectal Cancer Rep 2014;10:45-54.
5. Cogliano VJ, Baan R, Straif K, Grosse Y, Lauby-Secretan B, El Ghissassi F, Bouvard V, Benbrahim-Tallaa L, Guha N, Freeman C, et al. Preventable exposures associated with human cancers. J Natl Cancer Inst 2011;103:1827-39.
6. World Cancer Research Fund/American Institute for Cancer Research. Continuous update project report. Food, nutrition, physical activity, and the prevention of colorectal cancer. 2011.
7. Santarelli RL, Pierre F, Corpet DE. Processed meat and colorectal cancer: a review of epidemiologic and experimental evidence. Nutr Cancer 2008;60:131-44.
8. Santarelli RL, Vendeuvre JL, Naud N, Tache S, Gueraud F, Viau M, Genot C, Corpet DE, Pierre FH. Meat processing and colon carcinogenesis: cooked, nitrite-treated, and oxidized high-heme cured meat promotes mucin-depleted foci in rats. Cancer Prev Res (Phila) 2010;3:852-64.
9. Oates PS, West AR. Heme in intestinal epithelial cell turnover, differentiation, detoxification, inflammation, carcinogenesis, absorption and motility. World J Gastroenterol 2006;12: 4281-95.
10. Le Leu RK, Young GP, Hu Y, Winter J, Conlon MA. Dietary red meat aggravates dextran sulfate sodium-induced colitis in mice whereas resistant starch attenuates inflammation. Dig Dis Sci 2013; 58:3475-82.
11. Murphy N, Norat T, Ferrari P, Jenab M, Bueno-de-Mesquita B, Skeie G, Dahm CC, Overvad K, Olsen A, Tjonneland A, et al. Dietary fibre intake and risks of cancers of the colon and rectum in the European prospective investigation into cancer and nutrition (EPIC). PLoS One 2012;7:e39361.
12. Bingham SA. Mechanisms and experimental and epidemiological evidence relating dietary fibre (non-starch polysaccharides) and starch to protection against large bowel cancer. Proc Nutr Soc 1990; 49:153-71.
13. De Preter V, Rutgeerts P, Schuit F, Verbeke K, Arijs I. Impaired expression of genes involved in the butyrate oxidation pathway in Crohn's disease patients. Inflamm Bowel Dis 2013;19:E43-4.
14. Whitehead RH, Young GP, Bhathal PS. Effects of short chain fatty acids on a new human colon carcinoma cell line (LIM1215). Gut 1986;27:1457-63.
15. Heerdt BG, Houston MA, Augenlicht LH. Short-chain fatty acidinitiated cell cycle arrest and apoptosis of colonic epithelial cells is linked to mitochondrial function. Cell Growth Differ 1997;8: 523-32.
16. Segain JP, Raingeard de la Bletiere D, Bourreille A, Leray V, Gervois N, Rosales C, Ferrier L, Bonnet C, Blottiere HM, Galmiche JP. Butyrate inhibits inflammatory responses through NFkappaB inhibition: implications for Crohn's disease. Gut 2000;47: 397-403.
17. Andersen V, Holst R, Vogel U. Systematic review: diet-gene interactions and the risk of colorectal cancer. Aliment Pharmacol Ther 2013;37:383-91.
18. Chan AT, Tranah GJ, Giovannucci EL, Willett WC, Hunter DJ, Fuchs CS. Prospective study of N-acetyltransferase-2 genotypes, meat intake, smoking and risk of colorectal cancer. Int J Cancer 2005;115:648-52.
19. Shin A, Kim J. Effect modification of meat intake by genetic polymorphisms on colorectal neoplasia susceptibility. Asian Pac J Cancer Prev 2010;11:281-7.
20. Tiemersma EW, Kampman E, Bueno de Mesquita HB, Bunschoten A, van Schothorst EM, Kok FJ, Kromhout D. Meat consumption, cigarette smoking, and genetic susceptibility in the etiology of colorectal cancer: results from a Dutch prospective study. Cancer Causes Control 2002;13:383-93.
21. Chen J, Stampfer MJ, Hough HL, Garcia-Closas M, Willett WC, Hennekens CH, Kelsey KT, Hunter DJ. A prospective study of Nacetyltransferase genotype, red meat intake, and risk of colorectal cancer. Cancer Res 1998;58:3307-11.
22. Sørensen M, Autrup H, OlsenA, TjønnelandA,Overvad K, Raaschou-Nielsen O. Prospective study of NAT1 and NAT2 polymorphisms, tobacco smoking and meat consumption and risk of colorectal cancer. Cancer Lett 2008;266:186-93.
23. Nothlings U, Yamamoto JF, Wilkens LR, Murphy SP, Park SY, Henderson BE, Kolonel LN, Le Marchand L. Meat and heterocyclic amine intake, smoking, NAT1 and NAT2 polymorphisms, and colorectal cancer risk in the multiethnic cohort study. Cancer Epidemiol Biomarkers Prev 2009;18:2098-106.
24. Kopp TI, Andersen V, Tjonneland A, Vogel U. Polymorphisms in ATP-binding cassette transporter genes and interaction with diet and life style factors in relation to colorectal cancer in a Danish prospective case-cohort study. Scand J Gastroenterol 2015;50:1469-81.
25. Andersen V, Kopp T, Tjønneland A, Vogel U. No association between HMOX1 and risk of colorectal cancer and no interaction with diet and lifestyle factors in a prospective Danish case-cohort study. Int J Mol Sci 2015;16:1375-84.
26. Loh YH, Mitrou PN, Bowman R, Wood A, Jeffery H, Luben RN, Lentjes MAH, Khaw K-T, Rodwell SA. MGMT Ile143Val polymorphism, dietary factors and the risk of breast, colorectal and prostate cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Norfolk study. DNA Repair (Amst) 2010; 9:421-8.
27. Brevik A, Joshi AD, Corral R, Onland-Moret NC, Siegmund KD, Le Marchand L, Baron JA, Martinez ME, Haile RW, Ahnen DJ, et al. Polymorphisms in base excision repair genes as colorectal cancer risk factors and modifiers of the effect of diets high in red meat. Cancer Epidemiol Biomarkers Prev 2010;19:3167-73.
28. Andersen V, Holst R, Kopp TI, Tjonneland A, Vogel U. Interactions between diet, lifestyle and IL10, IL1B, and PTGS2/COX-2 gene polymorphisms in relation to risk of colorectal cancer in a prospective Danish case-cohort study. PLoS One 2013;8:e78366.
29. Kopp TI, Andersen V, Tjonneland A, Vogel U. Polymorphisms in NFKB1 and TLR4 and interaction with dietary and life style factors in relation to colorectal cancer in a Danish prospective case-cohort study. PLoS One 2015;10:e0116394.
30. Abreu MT. Toll-like receptor signalling in the intestinal epithelium: how bacterial recognition shapes intestinal function. Nat Rev 2010;10:131-44.
31. Akira S, Takeda K. Toll-like receptor signalling. Nat Rev 2004;4:499-511.
32. Paul G, Khare V, Gasche C. Inflamed gut mucosa: downstream of interleukin-10. Eur J Clin Invest 2012;42:95-109.
33. Tjonneland A, Olsen A, Boll K, Stripp C, Christensen J, Engholm G, Overvad K. Study design, exposure variables, and socioeconomic determinants of participation in Diet, Cancer and Health: a populationbased prospective cohort study of 57,053 men andwomen inDenmark. Scand J Public Health 2007;35:432-41.
34. Barlow WE, Ichikawa L, Rosner D, Izumi S. Analysis of case-cohort designs. J Clin Epidemiol 1999;52:1165-72.
35. Andersen V, Egeberg R, Tjonneland A, Vogel U. Interaction between interleukin-10 (IL-10) polymorphisms and dietary fibre in relation to risk of colorectal cancer in a Danish case-cohort study. BMC Cancer 2012;12:183.
36. Andersen V, Christensen J, Ernst A, Jacobsen BA, Tjonneland A, Krarup HB, Vogel U. Polymorphisms in NF-kappaB, PXR, LXR, PPARgamma and risk of inflammatory bowel disease. World J Gastroenterol 2011;17:197-206.
37. Tjonneland A, Overvad K, Haraldsdottir J, Bang S, Ewertz M, Jensen OM. Validation of a semiquantitative food frequency questionnaire developed in Denmark. Int J Epidemiol 1991;20:906-12.
38. Prosky L, Asp NG, Schweizer TF, DeVries JW, Furda I, Lee SC. Determination of soluble dietary fiber in foods and food products: collaborative study. J AOAC Int 1994;77:690-4.
39. Miller SA, Dykes DD, Polesky HF. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res 1988;16:1215.
40. Gast A, Bermejo JL, Claus R, Brandt A, Weires M, Weber A, Plass C, Sucker A, Hemminki K, Schadendorf D, et al. Association of inherited variation in Toll-like receptor genes with malignant melanoma susceptibility and survival. PLoS One 2011;6:e24370.
41. Consortium IH. The international HapMap project. Nature 2003;426:789-96.
42. Luan JA,Wong MY,Day NE,Wareham NJ. Sample size determination for studies of gene-environment interaction. Int J Epidemiol. 2001;30:1035-40.
43. Barlow WE. Robust variance estimation for the case-cohort design. Biometrics 1994;50:1064-72.
44. Overby NC, Sonestedt E, LaaksonenDE, Birgisdottir BE.Dietary fiber and the glycemic index: a background paper for the Nordic Nutrition Recommendations 2012. Food Nutr Res 2013;57:20709.
45. Astrup AV, Andersen NL, Stender S, Trolle E. [Dietary Recommendations 2005]. Ugeskr Laeger 2005;167:2296-9.
46. Andersen V,VogelU. Systematic review: interactions between aspirin, and other nonsteroidal anti-inflammatory drugs, and polymorphisms in relation to colorectal cancer. Aliment Pharmacol Ther 2014;40:147-59.
47. Kopp TI, Jensen DM, Ravn-Haren G, Cohen A, Sommer HM, Dragsted LO, Tjonneland A, Hougarard DM, Vogel U. Alcoholrelated breast cancer in postmenopausal women-effect of CYP19A1, PPARG and PPARGC1A polymorphisms on female sex-hormone levels and interaction with alcohol consumption and NSAID usage in a nested case-control study and a randomised controlled tr. BMCCancer 2016;16:283.
48. de Kivit S, Tobin MC, Forsyth CB, Keshavarzian A, Landay AL. Regulation of intestinal immune responses through TLR activation: implications for pro-and prebiotics. Front Immunol 2014;5:60.
49. Regan T, Nally K, Carmody R, Houston A, Shanahan F, Macsharry J, Brint E. Identification of TLR10 as a key mediator of the inflammatory response to Listeria monocytogenes in intestinal epithelial cells and macrophages. J Immunol. 2013;191:6084-92.
50. Law JW-F, Ab Mutalib N-S, Chan K-G, Lee L-H. An insight into the isolation, enumeration, and molecular detection of Listeria monocytogenes in food. Front Microbiol 2015;6:1227.
51. Henriques AR, Gama LT, Fraqueza MJ. Tracking Listeria monocytogenes contamination and virulence-associated characteristics in the ready-to-eat meat-based food products industry according to the hygiene level. Int J Food Microbiol 2017;242: 101-6.
52. Silva DAL da, Dias MR, Cossi MVC, Castilho NPA de, Camargo AC, Nero LA. Hygiene and safety in the meat processing environment from butcher shops: microbiological contamination and Listeria monocytogenes. J Food Prot 2016;79:628-34.
53. Salvat G, Fravalo P. Risk assessment strategies for Europe: integrated safety strategy or final product control: example of Listeria monocytogenes in processed products from pork meat industry. Dtsch Tierarztl Wochenschr 2004;111:331-4.
54. Sofos JN, Geornaras I. Overview of current meat hygiene and safety risks and summary of recent studies on biofilms, and control of Escherichia coli O157:H7 in nonintact, and Listeria monocytogenes in ready-to-eat, meat products. Meat Sci 2010;86:2-14.
55. Rocourt J, BenEmbarek P, Toyofuku H, Schlundt J. Quantitative risk assessment of Listeria monocytogenes in ready-to-eat foods: the FAO/WHO approach. FEMS Immunol Med Microbiol 2003; 35:263-7.
56. Heinrich V, ZunabovicM, Varzakas T, Bergmair J, Kneifel W. Pulsed light treatment of different food types with a special focus on meat: a critical review. Crit Rev Food Sci Nutr 2016;56:591-613.
57. Alarcon-Rojo AD, Janacua H, Rodriguez JC, Paniwnyk L, Mason TJ. Power ultrasound in meat processing. Meat Sci 2015;107: 86-93.
58. Bajovic B, Bolumar T, Heinz V. Quality considerations with high pressure processing of fresh and value added meat products. Meat Sci 2012;92:280-9.
59. Erridge C. Accumulation of stimulants of Toll-like receptor (TLR)-2 and TLR4 in meat products stored at 5 degrees C. J Food Sci 2011;76:H72-9.
60. Capitán-Cañadas F, Ortega-González M, Guadix E, Zarzuelo A, Suárez MD, de Medina FS, Martínez-Augustin O. Prebiotic oligosaccharides directly modulate proinflammatory cytokine production in monocytes via activation of TLR4. Mol Nutr Food Res 2014;58:1098-110.
61. Lehmann S, Hiller J, van Bergenhenegouwen J, Knippels LMJ, Garssen J, Traidl-Hoffmann C. In vitro evidence for immunemodulatory properties of non-digestible oligosaccharides: direct effect on human monocyte derived dendritic cells. PLoS One 2015;10:e0132304.
62. Ortega-González M, Ocón B, Romero-Calvo I, Anzola A, Guadix E, Zarzuelo A, Suárez MD, Sánchez de Medina F, Martínez-Augustin O. Nondigestible oligosaccharides exert nonprebiotic effects on intestinal epithelial cells enhancing the immune response via activation of TLR4-NFκB. Mol Nutr Food Res 2014;58:384-93.
63. Merga Y, Campbell BJ, Rhodes JM. Mucosal barrier, bacteria and inflammatory bowel disease: possibilities for therapy. Dig Dis 2014;32:475-83.
64. Desai MS, Seekatz AM, Koropatkin NM, Kamada N, Hickey CA, Wolter M, Pudlo NA, Kitamoto S, Terrapon N, Muller A, et al. A dietary fiber-deprived gut microbiota degrades the colonic mucus barrier and enhances pathogen susceptibility. Cell. 2016;167:1339-53. e21.
65. Andersen V, Hansen AK, Heitmann BL. Potential impact of diet on treatment effect from anti-TNF drugs in inflammatory bowel disease. Nutrients 2017;9:286.
66. Windey K, De Preter V, Louat T, Schuit F, Herman J, Vansant G, Verbeke K. Modulation of protein fermentation does not affect fecal water toxicity: a randomized cross-over study in healthy subjects. PLoS One 2012;7:e52387.
67. Yao CK, Muir JG, Gibson PR. Review article: insights into colonic protein fermentation, its modulation and potential health implications. Aliment Pharmacol Ther 2016;43:181-96.
68. Gibson GR, Macfarlane GT, Cummings JH. Sulphate reducing bacteria and hydrogen metabolism in the human large intestine. Gut 1993;34:437-9.
69. Ijssennagger N, van der Meer R, van Mil SWC. Sulfide as a mucus barrier-breaker in inflammatory bowel disease? Trends Mol Med 2016;22:190-9.
70. Karban AS, Okazaki T, Panhuysen CI, Gallegos T, Potter JJ, Bailey-Wilson JE, Silverberg MS, Duerr RH, Cho JH, Gregersen PK, et al. Functional annotation of a novel NFKB1 promoter polymorphism that increases risk for ulcerative colitis. Hum Mol Genet 2004;13: 35-45.
71. Pereira SG, Oakley F. Nuclear factor-kappaB1: regulation and function. Int J Biochem Cell Biol 2008;40:1425-30.
72. Chen H, Wilkins LM, Aziz N, Cannings C, Wyllie DH, Bingle C, Rogus J, Beck JD, Offenbacher S, Cork MJ, et al. Single nucleotide polymorphisms in the human interleukin-1B gene affect transcription according to haplotype context. Hum Mol Genet 2006;15:519-29.
73. Imler J-L, Hoffmann Ja. Toll signaling: the TIReless quest for specificity. Nat Immunol 2003;4:105-6.
74. Xu Y, Tao X, Shen B, Horng T, Medzhitov R, Manley JL, Tong L. Structural basis for signal transduction by the Toll/interleukin-1 receptor domains. Nature 2000;408:111-5.
75. Mikacenic C, Reiner AP, Holden TD, Nickerson DA, Wurfel MM. Variation in the TLR10/TLR1/TLR6 locus is the major genetic determinant of interindividual difference in TLR1/2-mediated responses. Genes Immun 2013;14:52-7.
76. Perneger TV. What's wrong with Bonferroni adjustments. BMJ 1998;316:1236-8.
77. Tang F-B, Li Z-X, Wang Y-M, Zhang L, Ma J-L, Zhou T, Zhang Y, Gao J-J, Wu S, Yang T, et al. Toll-like receptor 1 and 10 polymorphisms, Helicobacter pylori susceptibility and risk of gastric lesions in a high-risk Chinese population. Infect Genet Evol 2015;31:263-9.
78. Omueti KO, Mazur DJ, Thompson KS, Lyle EA, Tapping RI. The polymorphism P315L of human toll-like receptor 1 impairs innate immune sensing of microbial cell wall components. J Immunol 2007;178:6387-94.
79. Plantinga TS, Johnson MD, Scott WK, van de Vosse E, Velez Edwards DR, Smith PB, Alexander BD, Yang JC, Kremer D, Laird GM, et al. Toll-like receptor 1 polymorphisms increase susceptibility to candidemia. J Infect Dis 2012;205:934-43.
80. Zhang F, Gao X-D, Wu W-W, Gao Y, Zhang Y-W, Wang S-P. Polymorphisms in toll-like receptors 2, 4 and 5 are associated with Legionella pneumophila infection. Infection 2013;41: 941-8.
81. Bank S, SkyttAndersen P, Burisch J, PedersenN, Roug S, Galsgaard J, Ydegaard Turino S, Broder Brodersen J, Rashid S, Kaiser Rasmussen B, et al. Polymorphisms in the inflammatory pathway genes TLR2, TLR4, TLR9, LY96, NFKBIA, NFKB1, TNFA, TNFRSF1A, IL6R, IL10, IL23R, PTPN22, and PPARG are associated with susceptibility of inflammatory bowel disease in a Danish cohort. PLoS One 2014;9:e98815.
82. Liu J, Rädler D, Illi S, Klucker E, Turan E, vonMutius E, Kabesch M, Schaub B. TLR2 polymorphisms influence neonatal regulatory T cells depending on maternal atopy. Allergy 2011;66:1020-9.
83. Bielinski SJ, Hall JL, Pankow JS, Boerwinkle E, Matijevic-Aleksic N, He M, Chambless L, Folsom AR. Genetic variants in TLR2 and TLR4 are associated with markers of monocyte activation: the Atherosclerosis Risk in Communities MRI Study. Hum Genet 2011;129:655-62.
84. Choe J, Kelker MS, Wilson IA. Crystal structure of human toll-like receptor 3 (TLR3) ectodomain. Science 2005;309:581-5.
85. Sironi M, Biasin M, Cagliani R, Forni D, De Luca M, Saulle I, Lo Caputo S, Mazzotta F, Macias J, Pineda JA, et al. A common polymorphism in TLR3 confers natural resistance to HIV-1 infection J Immunol. 2012;188:818-23.
86. Ryckman KK, Williams SM, Krohn MA, Simhan HN. Genetic association of Toll-like receptor 4 with cervical cytokine concentrations during pregnancy. Genes Immun 2009;10: 636-40.
87. Hawn TR, Verbon A, Lettinga KD, Zhao LP, Li SS, Laws RJ, Skerrett SJ, Beutler B, Schroeder L, Nachman A, et al. A common dominant TLR5 stop codon polymorphism abolishes flagellin signaling and is associated with susceptibility to legionnaires' disease. J Exp Med 2003;198:1563-72.
88. Merx S, Zimmer W, Neumaier M, Ahmad-Nejad P. Characterization and functional investigation of single nucleotide polymorphisms (SNPs) in the human TLR5 gene. Hum Mutat 2006;27:293.
89. Gewirtz AT, Vijay-Kumar M, Brant SR, Duerr RH, Nicolae DL, Cho JH. Dominant-negative TLR5 polymorphism reduces adaptive immune response to flagellin and negatively associates with Crohn's disease. Am J Physiol Gastrointest Liver Physiol 2006;290: G1157-63.
90. Requena T, Gazquez I, Moreno A, Batuecas A, Aran I, Soto-Varela A, Santos-Perez S, Perez N, Perez-Garrigues H, Lopez-Nevot A, et al. Allelic variants in TLR10 gene may influence bilateral affectation and clinical course of Meniere's disease. Immunogenetics 2013;65:345-55.
91. Langsenlehner U, Yazdani-Biuki B, Eder T, Renner W, Wascher TC, Paulweber B,Weitzer W, Samonigg H, Krippl P. The cyclooxygenase-2 (PTGS2) 8473TC polymorphism is associated with breast cancer risk. Clin Cancer Res 2006;12:1392-4.
92. Sanak M, Szczeklik W, Szczeklik A. Association of COX-2 gene haplotypes with prostaglandins production in bronchial asthma. J Allergy Clin Immunol 2005;116:221-3.
93. Papafili A, Hill MR, Brull DJ, McAnulty RJ, Marshall RP, Humphries SE, Laurent GJ. Common promoter variant in cyclooxygenase-2 represses gene expression: evidence of role in acute-phase inflammatory response. Arterioscler Thromb Vasc Biol 2002;22:1631-6.
94. Franke A, Balschun T, Karlsen TH, Sventoraityte J, Nikolaus S, Mayr G, Domingues FS, Albrecht M, Nothnagel M, Ellinghaus D, et al. Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility. Nat Genet 2008;40:1319-23.
95. Andersen V, Ernst A, Christensen J, Ostergaard M, Jacobsen BA, Tjonneland A, Krarup HB, Vogel U. The polymorphism rs3024505 proximal to IL-10 is associated with risk of ulcerative colitis and Crohns disease in a Danish case-control study. BMC Med Genet 2010;11:82.
96. Mohd Suzairi MS, Tan SC, Ahmad Aizat AA, Mohd Aminudin M, Siti Nurfatimah MS, Andee ZD, Ankathil R. The functional-94 insertion/deletion ATTG polymorphism in the promoter region of NFKB1 gene increases the risk of sporadic colorectal cancer. Cancer Epidemiol 2013;37:634-8.
97. Andersen V, Christensen J, Overvad K, Tjonneland A, Vogel U. Polymorphisms in NFkB, PXR, LXR and risk of colorectal cancer in a prospective study of Danes. BMC Cancer 2010;10:484.
98. Lewander A, Butchi AK, Gao J, He LJ, Lindblom A, Arbman G, Carstensen J, Zhang ZY, Sun XF, Group SL-RCCS. Polymorphism in the promoter region of the NFKB1 gene increases the risk of sporadic colorectal cancer in Swedish but not in Chinese populations. Scand J Gastroenterol 2007;42:1332-8.
99. Borm ME, van Bodegraven AA, Mulder CJ, Kraal G, Bouma G. A NFKB1 promoter polymorphism is involved in susceptibility to ulcerative colitis. Int J Immunogenet 2005;32:401-5.
100. Bank S, Andersen PS, Burisch J, Pedersen N, Roug S, Galsgaard J, Turino SY, Brodersen JB, Rashid S, Rasmussen BK, et al. Associations between functional polymorphisms in the NFkappaB signaling pathway and response to anti-TNF treatment in Danish patients with inflammatory bowel disease. Pharmacogenomics J 2014;14:526-34.