-
1
-
-
84944339068
-
Gene therapy returns to centre stage
-
Naldini L. Gene therapy returns to centre stage. Nature (2015) 526(7573):351-60. doi:10.1038/nature15818
-
(2015)
Nature
, vol.526
, Issue.7573
, pp. 351-360
-
-
Naldini, L.1
-
2
-
-
85015160162
-
Clinical development of gene therapy: results and lessons from recent successes
-
Kumar SR, Markusic DM, Biswas M, High KA, Herzog RW. Clinical development of gene therapy: results and lessons from recent successes. Mol Ther Methods Clin Dev (2016) 3:16034. doi:10.1038/mtm.2016.34
-
(2016)
Mol Ther Methods Clin Dev
, vol.3
, pp. 16034
-
-
Kumar, S.R.1
Markusic, D.M.2
Biswas, M.3
High, K.A.4
Herzog, R.W.5
-
3
-
-
0034724857
-
Gene therapy of human severe combined immunodeficiency (SCID)-X1 disease
-
Cavazzana-Calvo M, Hacein-Bey S, de Saint Basile G, Gross F, Yvon E, Nusbaum P, et al. Gene therapy of human severe combined immunodeficiency (SCID)-X1 disease. Science (2000) 288(5466):669-72. doi:10.1126/science.288.5466.669
-
(2000)
Science
, vol.288
, Issue.5466
, pp. 669-672
-
-
Cavazzana-Calvo, M.1
Hacein-Bey, S.2
de Saint Basile, G.3
Gross, F.4
Yvon, E.5
Nusbaum, P.6
-
4
-
-
44249085878
-
Safety and efficacy of gene transfer for Leber's congenital amaurosis
-
Maguire AM, Simonelli F, Pierce EA, Pugh EN Jr, Mingozzi F, Bennicelli J, et al. Safety and efficacy of gene transfer for Leber's congenital amaurosis. N Engl J Med (2008) 358(21):2240-8. doi:10.1056/NEJMoa0802315
-
(2008)
N Engl J Med
, vol.358
, Issue.21
, pp. 2240-2248
-
-
Maguire, A.M.1
Simonelli, F.2
Pierce, E.A.3
Pugh E.N, Jr.4
Mingozzi, F.5
Bennicelli, J.6
-
5
-
-
59449098985
-
Gene therapy for immunodeficiency due to adenosine deaminase deficiency
-
Aiuti A, Cattaneo F, Galimberti S, Benninghoff U, Cassani B, Callegaro L, et al. Gene therapy for immunodeficiency due to adenosine deaminase deficiency. N Engl J Med (2009) 360(5):447-58. doi:10.1056/NEJMoa0805817
-
(2009)
N Engl J Med
, vol.360
, Issue.5
, pp. 447-458
-
-
Aiuti, A.1
Cattaneo, F.2
Galimberti, S.3
Benninghoff, U.4
Cassani, B.5
Callegaro, L.6
-
6
-
-
77956928344
-
Transfusion independence and HMGA2 activation after gene therapy of human beta-thalassaemia
-
Cavazzana-Calvo M, Payen E, Negre O, Wang G, Hehir K, Fusil F, et al. Transfusion independence and HMGA2 activation after gene therapy of human beta-thalassaemia. Nature (2010) 467(7313):318-22. doi:10.1038/nature09328
-
(2010)
Nature
, vol.467
, Issue.7313
, pp. 318-322
-
-
Cavazzana-Calvo, M.1
Payen, E.2
Negre, O.3
Wang, G.4
Hehir, K.5
Fusil, F.6
-
7
-
-
84911383748
-
Long-term safety and efficacy of factor IX gene therapy in hemophilia B
-
Nathwani AC, Reiss UM, Tuddenham EG, Rosales C, Chowdary P, McIntosh J, et al. Long-term safety and efficacy of factor IX gene therapy in hemophilia B. N Engl J Med (2014) 371(21):1994-2004. doi:10.1056/NEJMoa1407309
-
(2014)
N Engl J Med
, vol.371
, Issue.21
, pp. 1994-2004
-
-
Nathwani, A.C.1
Reiss, U.M.2
Tuddenham, E.G.3
Rosales, C.4
Chowdary, P.5
McIntosh, J.6
-
8
-
-
85014855434
-
Gene therapy in a patient with sickle cell disease
-
Ribeil JA, Hacein-Bey-Abina S, Payen E, Magnani A, Semeraro M, Magrin E, et al. Gene therapy in a patient with sickle cell disease. N Engl J Med (2017) 376(9):848-55. doi:10.1056/NEJMoa1609677
-
(2017)
N Engl J Med
, vol.376
, Issue.9
, pp. 848-855
-
-
Ribeil, J.A.1
Hacein-Bey-Abina, S.2
Payen, E.3
Magnani, A.4
Semeraro, M.5
Magrin, E.6
-
9
-
-
54949104686
-
Treatment of leber congenital amaurosis due to RPE65 mutations by ocular subretinal injection of adeno-associated virus gene vector: short-term results of a phase I trial
-
Hauswirth WW, Aleman TS, Kaushal S, Cideciyan AV, Schwartz SB, Wang L, et al. Treatment of leber congenital amaurosis due to RPE65 mutations by ocular subretinal injection of adeno-associated virus gene vector: short-term results of a phase I trial. Hum Gene Ther (2008) 19(10):979-90. doi:10.1089/hum.2008.107
-
(2008)
Hum Gene Ther
, vol.19
, Issue.10
, pp. 979-990
-
-
Hauswirth, W.W.1
Aleman, T.S.2
Kaushal, S.3
Cideciyan, A.V.4
Schwartz, S.B.5
Wang, L.6
-
10
-
-
0036147402
-
Assessment of adenoviral vector safety and toxicity: report of the National Institutes of Health Recombinant DNA Advisory Committee.
-
Assessment of adenoviral vector safety and toxicity: report of the National Institutes of Health Recombinant DNA Advisory Committee. Hum Gene Ther (2002) 13(1):3-13. doi:10.1089/10430340152712629
-
(2002)
Hum Gene Ther
, vol.13
, Issue.1
, pp. 3-13
-
-
-
11
-
-
34250683023
-
Safety and tolerability of gene therapy with an adeno-associated virus (AAV) borne GAD gene for Parkinson's disease: an open label, phase I trial
-
Kaplitt MG, Feigin A, Tang C, Fitzsimons HL, Mattis P, Lawlor PA, et al. Safety and tolerability of gene therapy with an adeno-associated virus (AAV) borne GAD gene for Parkinson's disease: an open label, phase I trial. Lancet (2007) 369(9579):2097-105. doi:10.1016/S0140-6736(07)60982-9
-
(2007)
Lancet
, vol.369
, Issue.9579
, pp. 2097-2105
-
-
Kaplitt, M.G.1
Feigin, A.2
Tang, C.3
Fitzsimons, H.L.4
Mattis, P.5
Lawlor, P.A.6
-
12
-
-
44249120315
-
Effect of gene therapy on visual function in Leber's congenital amaurosis
-
Bainbridge JW, Smith AJ, Barker SS, Robbie S, Henderson R, Balaggan K, et al. Effect of gene therapy on visual function in Leber's congenital amaurosis. N Engl J Med (2008) 358(21):2231-9. doi:10.1056/NEJMoa0802268
-
(2008)
N Engl J Med
, vol.358
, Issue.21
, pp. 2231-2239
-
-
Bainbridge, J.W.1
Smith, A.J.2
Barker, S.S.3
Robbie, S.4
Henderson, R.5
Balaggan, K.6
-
13
-
-
19344366672
-
Systemic protein delivery by muscle-gene transfer is limited by a local immune response
-
Wang L, Dobrzynski E, Schlachterman A, Cao O, Herzog RW. Systemic protein delivery by muscle-gene transfer is limited by a local immune response. Blood (2005) 105(11):4226-34. doi:10.1182/blood-2004-03-0848
-
(2005)
Blood
, vol.105
, Issue.11
, pp. 4226-4234
-
-
Wang, L.1
Dobrzynski, E.2
Schlachterman, A.3
Cao, O.4
Herzog, R.W.5
-
14
-
-
72149123930
-
Gene therapy. Beta-thalassemia treatment succeeds, with a caveat
-
Kaiser J. Gene therapy. Beta-thalassemia treatment succeeds, with a caveat. Science (2009) 326(5959):1468-9. doi:10.1126/science.326.5959.1468-b
-
(2009)
Science
, vol.326
, Issue.5959
, pp. 1468-1469
-
-
Kaiser, J.1
-
15
-
-
84879867061
-
Lentiviral hematopoietic stem cell gene therapy in patients with Wiskott-Aldrich syndrome
-
Aiuti A, Biasco L, Scaramuzza S, Ferrua F, Cicalese MP, Baricordi C, et al. Lentiviral hematopoietic stem cell gene therapy in patients with Wiskott-Aldrich syndrome. Science (2013) 341(6148):1233151. doi:10.1126/science.1233151
-
(2013)
Science
, vol.341
, Issue.6148
, pp. 1233151
-
-
Aiuti, A.1
Biasco, L.2
Scaramuzza, S.3
Ferrua, F.4
Cicalese, M.P.5
Baricordi, C.6
-
16
-
-
84887122632
-
Liver gene therapy by lentiviral vectors reverses anti-factor IX pre-existing immunity in haemophilic mice
-
Annoni A, Cantore A, Della Valle P, Goudy K, Akbarpour M, Russo F, et al. Liver gene therapy by lentiviral vectors reverses anti-factor IX pre-existing immunity in haemophilic mice. EMBO Mol Med (2013) 5(11):1684-97. doi:10.1002/emmm.201302857
-
(2013)
EMBO Mol Med
, vol.5
, Issue.11
, pp. 1684-1697
-
-
Annoni, A.1
Cantore, A.2
Della Valle, P.3
Goudy, K.4
Akbarpour, M.5
Russo, F.6
-
17
-
-
84929018147
-
Liver-directed lentiviral gene therapy in a dog model of hemophilia B
-
Cantore A, Ranzani M, Bartholomae CC, Volpin M, Valle PD, Sanvito F, et al. Liver-directed lentiviral gene therapy in a dog model of hemophilia B. Sci Transl Med (2015) 7(277):277ra228. doi:10.1126/scitranslmed.aaa1405
-
(2015)
Sci Transl Med
, vol.7
, Issue.277
, pp. 277ra228
-
-
Cantore, A.1
Ranzani, M.2
Bartholomae, C.C.3
Volpin, M.4
Valle, P.D.5
Sanvito, F.6
-
18
-
-
84879556481
-
Hepatic gene therapy using lentiviral vectors: has safety been established?
-
Dismuke D, Samulski RJ. Hepatic gene therapy using lentiviral vectors: has safety been established? Hepatology (2013) 58(1):13-4. doi:10.1002/hep.26460
-
(2013)
Hepatology
, vol.58
, Issue.1
, pp. 13-14
-
-
Dismuke, D.1
Samulski, R.J.2
-
19
-
-
20844463069
-
Stability of lentiviral vector-mediated transgene expression in the brain in the presence of systemic antivector immune responses
-
Abordo-Adesida E, Follenzi A, Barcia C, Sciascia S, Castro MG, Naldini L, et al. Stability of lentiviral vector-mediated transgene expression in the brain in the presence of systemic antivector immune responses. Hum Gene Ther (2005) 16(6):741-51. doi:10.1089/hum.2005.16.741
-
(2005)
Hum Gene Ther
, vol.16
, Issue.6
, pp. 741-751
-
-
Abordo-Adesida, E.1
Follenzi, A.2
Barcia, C.3
Sciascia, S.4
Castro, M.G.5
Naldini, L.6
-
20
-
-
84874360062
-
A self-deletion lentiviral vector to reduce the risk of replication-competent virus formation
-
Fang Y, Gong X, Xu M, Zeng F, Zhang J. A self-deletion lentiviral vector to reduce the risk of replication-competent virus formation. J Gene Med (2013) 15(2):102-12. doi:10.1002/jgm.2700
-
(2013)
J Gene Med
, vol.15
, Issue.2
, pp. 102-112
-
-
Fang, Y.1
Gong, X.2
Xu, M.3
Zeng, F.4
Zhang, J.5
-
21
-
-
33947583453
-
In vivo administration of lentiviral vectors triggers a type I interferon response that restricts hepatocyte gene transfer and promotes vector clearance
-
Brown BD, Sitia G, Annoni A, Hauben E, Sergi LS, Zingale A, et al. In vivo administration of lentiviral vectors triggers a type I interferon response that restricts hepatocyte gene transfer and promotes vector clearance. Blood (2007) 109(7):2797-805. doi:10.1182/blood-2006-10-049312
-
(2007)
Blood
, vol.109
, Issue.7
, pp. 2797-2805
-
-
Brown, B.D.1
Sitia, G.2
Annoni, A.3
Hauben, E.4
Sergi, L.S.5
Zingale, A.6
-
22
-
-
77951993592
-
HIV-1 lentiviral vector immunogenicity is mediated by toll-like receptor 3 (TLR3) and TLR7
-
Breckpot K, Escors D, Arce F, Lopes L, Karwacz K, Van Lint S, et al. HIV-1 lentiviral vector immunogenicity is mediated by toll-like receptor 3 (TLR3) and TLR7. J Virol (2010) 84(11):5627-36. doi:10.1128/JVI.00014-10
-
(2010)
J Virol
, vol.84
, Issue.11
, pp. 5627-5636
-
-
Breckpot, K.1
Escors, D.2
Arce, F.3
Lopes, L.4
Karwacz, K.5
Van Lint, S.6
-
23
-
-
84870594961
-
A TLR and non-TLR mediated innate response to lentiviruses restricts hepatocyte entry and can be ameliorated by pharmacological blockade
-
Agudo J, Ruzo A, Kitur K, Sachidanandam R, Blander JM, Brown BD. A TLR and non-TLR mediated innate response to lentiviruses restricts hepatocyte entry and can be ameliorated by pharmacological blockade. Mol Ther (2012) 20(12):2257-67. doi:10.1038/mt.2012.150
-
(2012)
Mol Ther
, vol.20
, Issue.12
, pp. 2257-2267
-
-
Agudo, J.1
Ruzo, A.2
Kitur, K.3
Sachidanandam, R.4
Blander, J.M.5
Brown, B.D.6
-
24
-
-
0029936764
-
Immune responses to transgene-encoded proteins limit the stability of gene expression after injection of replication-defective adenovirus vectors
-
Tripathy SK, Black HB, Goldwasser E, Leiden JM. Immune responses to transgene-encoded proteins limit the stability of gene expression after injection of replication-defective adenovirus vectors. Nat Med (1996) 2(5):545-50. doi:10.1038/nm0596-545
-
(1996)
Nat Med
, vol.2
, Issue.5
, pp. 545-550
-
-
Tripathy, S.K.1
Black, H.B.2
Goldwasser, E.3
Leiden, J.M.4
-
25
-
-
9244220682
-
Immune responses to viral antigens versus transgene product in the elimination of recombinant adenovirus-infected hepatocytes in vivo
-
Yang Y, Jooss KU, Su Q, Ertl HC, Wilson JM. Immune responses to viral antigens versus transgene product in the elimination of recombinant adenovirus-infected hepatocytes in vivo. Gene Ther (1996) 3(2):137-44.
-
(1996)
Gene Ther
, vol.3
, Issue.2
, pp. 137-144
-
-
Yang, Y.1
Jooss, K.U.2
Su, Q.3
Ertl, H.C.4
Wilson, J.M.5
-
26
-
-
11144248909
-
The innate immune response to adenovirus vectors
-
Muruve DA. The innate immune response to adenovirus vectors. Hum Gene Ther (2004) 15(12):1157-66. doi:10.1089/hum.2004.15.1157
-
(2004)
Hum Gene Ther
, vol.15
, Issue.12
, pp. 1157-1166
-
-
Muruve, D.A.1
-
27
-
-
85018193995
-
Chimpanzee adenovirus vector Ebola vaccine
-
Ledgerwood JE, DeZure AD, Stanley DA, Coates EE, Novik L, Enama ME, et al. Chimpanzee adenovirus vector Ebola vaccine. N Engl J Med (2017) 376(10):928-38. doi:10.1056/NEJMoa1410863
-
(2017)
N Engl J Med
, vol.376
, Issue.10
, pp. 928-938
-
-
Ledgerwood, J.E.1
DeZure, A.D.2
Stanley, D.A.3
Coates, E.E.4
Novik, L.5
Enama, M.E.6
-
28
-
-
27544513676
-
Gutless adenovirus: last-generation adenovirus for gene therapy
-
Alba R, Bosch A, Chillon M. Gutless adenovirus: last-generation adenovirus for gene therapy. Gene Ther (2005) 12(Suppl 1):S18-27. doi:10.1038/sj.gt.3302612
-
(2005)
Gene Ther
, vol.12
, pp. S18-27
-
-
Alba, R.1
Bosch, A.2
Chillon, M.3
-
29
-
-
2442638935
-
Helper-dependent adenovirus vectors elicit intact innate but attenuated adaptive host immune responses in vivo
-
Muruve DA, Cotter MJ, Zaiss AK, White LR, Liu Q, Chan T, et al. Helper-dependent adenovirus vectors elicit intact innate but attenuated adaptive host immune responses in vivo. J Virol (2004) 78(11):5966-72. doi:10.1128/JVI.78.11.5966-5972.2004
-
(2004)
J Virol
, vol.78
, Issue.11
, pp. 5966-5972
-
-
Muruve, D.A.1
Cotter, M.J.2
Zaiss, A.K.3
White, L.R.4
Liu, Q.5
Chan, T.6
-
30
-
-
44049083209
-
Immunity to adeno-associated virus vectors in animals and humans: a continued challenge
-
Zaiss AK, Muruve DA. Immunity to adeno-associated virus vectors in animals and humans: a continued challenge. Gene Ther (2008) 15(11):808-16. doi:10.1038/gt.2008.54
-
(2008)
Gene Ther
, vol.15
, Issue.11
, pp. 808-816
-
-
Zaiss, A.K.1
Muruve, D.A.2
-
31
-
-
68849103488
-
The TLR9-MyD88 pathway is critical for adaptive immune responses to adeno-associated virus gene therapy vectors in mice
-
Zhu J, Huang X, Yang Y. The TLR9-MyD88 pathway is critical for adaptive immune responses to adeno-associated virus gene therapy vectors in mice. J Clin Invest (2009) 119(8):2388-98. doi:10.1172/JCI37607
-
(2009)
J Clin Invest
, vol.119
, Issue.8
, pp. 2388-2398
-
-
Zhu, J.1
Huang, X.2
Yang, Y.3
-
32
-
-
85021083587
-
Plasmacytoid and conventional dendritic cells cooperate in crosspriming AAV capsid-specific CD8+ T cells
-
Rogers GL, Shirley JL, Zolotukhin I, Kumar SRP, Sherman A, Perrin GQ, et al. Plasmacytoid and conventional dendritic cells cooperate in crosspriming AAV capsid-specific CD8+ T cells. Blood (2017) 129(24):3184-95. doi:10.1182/blood-2016-11-751040
-
(2017)
Blood
, vol.129
, Issue.24
, pp. 3184-3195
-
-
Rogers, G.L.1
Shirley, J.L.2
Zolotukhin, I.3
Kumar, S.R.P.4
Sherman, A.5
Perrin, G.Q.6
-
33
-
-
33644820684
-
Successful transduction of liver in hemophilia by AAV-factor IX and limitations imposed by the host immune response
-
Manno CS, Pierce GF, Arruda VR, Glader B, Ragni M, Rasko JJ, et al. Successful transduction of liver in hemophilia by AAV-factor IX and limitations imposed by the host immune response. Nat Med (2006) 12(3):342-7. doi:10.1038/nm1358
-
(2006)
Nat Med
, vol.12
, Issue.3
, pp. 342-347
-
-
Manno, C.S.1
Pierce, G.F.2
Arruda, V.R.3
Glader, B.4
Ragni, M.5
Rasko, J.J.6
-
34
-
-
34147098413
-
CD8(+) T-cell responses to adeno-associated virus capsid in humans
-
Mingozzi F, Maus MV, Hui DJ, Sabatino DE, Murphy SL, Rasko JE, et al. CD8(+) T-cell responses to adeno-associated virus capsid in humans. Nat Med (2007) 13(4):419-22. doi:10.1038/nm1549
-
(2007)
Nat Med
, vol.13
, Issue.4
, pp. 419-422
-
-
Mingozzi, F.1
Maus, M.V.2
Hui, D.J.3
Sabatino, D.E.4
Murphy, S.L.5
Rasko, J.E.6
-
35
-
-
67651006589
-
Capsid antigen presentation flags human hepatocytes for destruction after transduction by adeno-associated viral vectors
-
Pien GC, Basner-Tschakarjan E, Hui DJ, Mentlik AN, Finn JD, Hasbrouck NC, et al. Capsid antigen presentation flags human hepatocytes for destruction after transduction by adeno-associated viral vectors. J Clin Invest (2009) 119(6):1688-95. doi:10.1172/JCI36891
-
(2009)
J Clin Invest
, vol.119
, Issue.6
, pp. 1688-1695
-
-
Pien, G.C.1
Basner-Tschakarjan, E.2
Hui, D.J.3
Mentlik, A.N.4
Finn, J.D.5
Hasbrouck, N.C.6
-
36
-
-
84855161388
-
Adenovirus-associated virus vector-mediated gene transfer in hemophilia B
-
Nathwani AC, Tuddenham EG, Rangarajan S, Rosales C, McIntosh J, Linch DC, et al. Adenovirus-associated virus vector-mediated gene transfer in hemophilia B. N Engl J Med (2011) 365(25):2357-65. doi:10.1056/NEJMoa1108046
-
(2011)
N Engl J Med
, vol.365
, Issue.25
, pp. 2357-2365
-
-
Nathwani, A.C.1
Tuddenham, E.G.2
Rangarajan, S.3
Rosales, C.4
McIntosh, J.5
Linch, D.C.6
-
37
-
-
77954141914
-
FOXP3+ regulatory T cells in the human immune system
-
Sakaguchi S, Miyara M, Costantino CM, Hafler DA. FOXP3+ regulatory T cells in the human immune system. Nat Rev Immunol (2010) 10(7):490-500. doi:10.1038/nri2785
-
(2010)
Nat Rev Immunol
, vol.10
, Issue.7
, pp. 490-500
-
-
Sakaguchi, S.1
Miyara, M.2
Costantino, C.M.3
Hafler, D.A.4
-
38
-
-
33847667225
-
The role of T helper 17 (Th17) and regulatory T cells (Treg) in human organ transplantation and autoimmune disease
-
Afzali B, Lombardi G, Lechler RI, Lord GM. The role of T helper 17 (Th17) and regulatory T cells (Treg) in human organ transplantation and autoimmune disease. Clin Exp Immunol (2007) 148(1):32-46. doi:10.1111/j.1365-2249.2007.03356.x
-
(2007)
Clin Exp Immunol
, vol.148
, Issue.1
, pp. 32-46
-
-
Afzali, B.1
Lombardi, G.2
Lechler, R.I.3
Lord, G.M.4
-
39
-
-
77951626075
-
Regulatory T cells in cancer
-
Mougiakakos D, Choudhury A, Lladser A, Kiessling R, Johansson CC. Regulatory T cells in cancer. Adv Cancer Res (2010) 107:57-117. doi:10.1016/S0065-230X(10)07003-X
-
(2010)
Adv Cancer Res
, vol.107
, pp. 57-117
-
-
Mougiakakos, D.1
Choudhury, A.2
Lladser, A.3
Kiessling, R.4
Johansson, C.C.5
-
40
-
-
85006789449
-
Regulatory T cells in cancer immunotherapy
-
Tanaka A, Sakaguchi S. Regulatory T cells in cancer immunotherapy. Cell Res (2017) 27(1):109-18. doi:10.1038/cr.2016.151
-
(2017)
Cell Res
, vol.27
, Issue.1
, pp. 109-118
-
-
Tanaka, A.1
Sakaguchi, S.2
-
41
-
-
25844504653
-
Developmental regulation of Foxp3 expression during ontogeny
-
Fontenot JD, Dooley JL, Farr AG, Rudensky AY. Developmental regulation of Foxp3 expression during ontogeny. J Exp Med (2005) 202(7):901-6. doi:10.1084/jem.20050784
-
(2005)
J Exp Med
, vol.202
, Issue.7
, pp. 901-906
-
-
Fontenot, J.D.1
Dooley, J.L.2
Farr, A.G.3
Rudensky, A.Y.4
-
42
-
-
84874141619
-
The cellular and molecular mechanisms of immuno-suppression by human type 1 regulatory T cells
-
Gregori S, Goudy KS, Roncarolo MG. The cellular and molecular mechanisms of immuno-suppression by human type 1 regulatory T cells. Front Immunol (2012) 3:30. doi:10.3389/fimmu.2012.00030
-
(2012)
Front Immunol
, vol.3
, pp. 30
-
-
Gregori, S.1
Goudy, K.S.2
Roncarolo, M.G.3
-
43
-
-
84880275285
-
Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells
-
Gagliani N, Magnani CF, Huber S, Gianolini ME, Pala M, Licona-Limon P, et al. Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells. Nat Med (2013) 19(6):739-46. doi:10.1038/nm.3179
-
(2013)
Nat Med
, vol.19
, Issue.6
, pp. 739-746
-
-
Gagliani, N.1
Magnani, C.F.2
Huber, S.3
Gianolini, M.E.4
Pala, M.5
Licona-Limon, P.6
-
44
-
-
47249119632
-
Latency-associated peptide identifies a novel CD4+CD25+ regulatory T cell subset with TGFbeta-mediated function and enhanced suppression of experimental autoimmune encephalomyelitis
-
Chen ML, Yan BS, Bando Y, Kuchroo VK, Weiner HL. Latency-associated peptide identifies a novel CD4+CD25+ regulatory T cell subset with TGFbeta-mediated function and enhanced suppression of experimental autoimmune encephalomyelitis. J Immunol (2008) 180(11):7327-37. doi:10.4049/jimmunol.180.11.7327
-
(2008)
J Immunol
, vol.180
, Issue.11
, pp. 7327-7337
-
-
Chen, M.L.1
Yan, B.S.2
Bando, Y.3
Kuchroo, V.K.4
Weiner, H.L.5
-
45
-
-
67649518909
-
Neuropilin-1 is not a marker of human Foxp3+ Treg
-
Milpied P, Renand A, Bruneau J, Mendes-da-Cruz DA, Jacquelin S, Asnafi V, et al. Neuropilin-1 is not a marker of human Foxp3+ Treg. Eur J Immunol (2009) 39(6):1466-71. doi:10.1002/eji.200839040
-
(2009)
Eur J Immunol
, vol.39
, Issue.6
, pp. 1466-1471
-
-
Milpied, P.1
Renand, A.2
Bruneau, J.3
Mendes-da-Cruz, D.A.4
Jacquelin, S.5
Asnafi, V.6
-
46
-
-
84867901322
-
Neuropilin-1 distinguishes natural and inducible regulatory T cells among regulatory T cell subsets in vivo
-
Yadav M, Louvet C, Davini D, Gardner JM, Martinez-Llordella M, Bailey-Bucktrout S, et al. Neuropilin-1 distinguishes natural and inducible regulatory T cells among regulatory T cell subsets in vivo. J Exp Med (2012) 209(10):S1-19. doi:10.1084/jem.20120822
-
(2012)
J Exp Med
, vol.209
, Issue.10
, pp. S1-19
-
-
Yadav, M.1
Louvet, C.2
Davini, D.3
Gardner, J.M.4
Martinez-Llordella, M.5
Bailey-Bucktrout, S.6
-
47
-
-
70149100480
-
CD44 costimulation promotes FoxP3+ regulatory T cell persistence and function via production of IL-2, IL-10, and TGF-beta
-
Bollyky PL, Falk BA, Long SA, Preisinger A, Braun KR, Wu RP, et al. CD44 costimulation promotes FoxP3+ regulatory T cell persistence and function via production of IL-2, IL-10, and TGF-beta. J Immunol (2009) 183(4):2232-41. doi:10.4049/jimmunol.0900191
-
(2009)
J Immunol
, vol.183
, Issue.4
, pp. 2232-2241
-
-
Bollyky, P.L.1
Falk, B.A.2
Long, S.A.3
Preisinger, A.4
Braun, K.R.5
Wu, R.P.6
-
48
-
-
79953170912
-
Differential phenotypic and genotypic characteristics of qnrS1-harboring plasmids carried by hospital and community commensal enterobacteria
-
Vien le TM, Abuoun M, Morrison V, Thomson N, Campbell JI, Woodward MJ, et al. Differential phenotypic and genotypic characteristics of qnrS1-harboring plasmids carried by hospital and community commensal enterobacteria. Antimicrob Agents Chemother (2011) 55(4):1798-802. doi:10.1128/AAC.01200-10
-
(2011)
Antimicrob Agents Chemother
, vol.55
, Issue.4
, pp. 1798-1802
-
-
Vien le, T.M.1
Abuoun, M.2
Morrison, V.3
Thomson, N.4
Campbell, J.I.5
Woodward, M.J.6
-
49
-
-
34250351459
-
Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression
-
Deaglio S, Dwyer KM, Gao W, Friedman D, Usheva A, Erat A, et al. Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression. J Exp Med (2007) 204(6):1257-65. doi:10.1084/jem.20062512
-
(2007)
J Exp Med
, vol.204
, Issue.6
, pp. 1257-1265
-
-
Deaglio, S.1
Dwyer, K.M.2
Gao, W.3
Friedman, D.4
Usheva, A.5
Erat, A.6
-
50
-
-
33847376532
-
Galectin-1: a key effector of regulation mediated by CD4+CD25+ T cells
-
Garin MI, Chu CC, Golshayan D, Cernuda-Morollon E, Wait R, Lechler RI. Galectin-1: a key effector of regulation mediated by CD4+CD25+ T cells. Blood (2007) 109(5):2058-65. doi:10.1182/blood-2006-04-016451
-
(2007)
Blood
, vol.109
, Issue.5
, pp. 2058-2065
-
-
Garin, M.I.1
Chu, C.C.2
Golshayan, D.3
Cernuda-Morollon, E.4
Wait, R.5
Lechler, R.I.6
-
51
-
-
34447330895
-
Human CD4+CD25+ regulatory T cells: proteome analysis identifies galectin-10 as a novel marker essential for their anergy and suppressive function
-
Kubach J, Lutter P, Bopp T, Stoll S, Becker C, Huter E, et al. Human CD4+CD25+ regulatory T cells: proteome analysis identifies galectin-10 as a novel marker essential for their anergy and suppressive function. Blood (2007) 110(5):1550-8. doi:10.1182/blood-2007-01-069229
-
(2007)
Blood
, vol.110
, Issue.5
, pp. 1550-1558
-
-
Kubach, J.1
Lutter, P.2
Bopp, T.3
Stoll, S.4
Becker, C.5
Huter, E.6
-
52
-
-
69449085219
-
GARP (LRRC32) is essential for the surface expression of latent TGF-beta on platelets and activated FOXP3+ regulatory T cells
-
Tran DQ, Andersson J, Wang R, Ramsey H, Unutmaz D, Shevach EM. GARP (LRRC32) is essential for the surface expression of latent TGF-beta on platelets and activated FOXP3+ regulatory T cells. Proc Natl Acad Sci U S A (2009) 106(32):13445-50. doi:10.1073/pnas.0901944106
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, Issue.32
, pp. 13445-13450
-
-
Tran, D.Q.1
Andersson, J.2
Wang, R.3
Ramsey, H.4
Unutmaz, D.5
Shevach, E.M.6
-
53
-
-
84878071516
-
Regulation of the expression of GARP/latent TGF-beta1 complexes on mouse T cells and their role in regulatory T cell and Th17 differentiation
-
Edwards JP, Fujii H, Zhou AX, Creemers J, Unutmaz D, Shevach EM. Regulation of the expression of GARP/latent TGF-beta1 complexes on mouse T cells and their role in regulatory T cell and Th17 differentiation. J Immunol (2013) 190(11):5506-15. doi:10.4049/jimmunol.1300199
-
(2013)
J Immunol
, vol.190
, Issue.11
, pp. 5506-5515
-
-
Edwards, J.P.1
Fujii, H.2
Zhou, A.X.3
Creemers, J.4
Unutmaz, D.5
Shevach, E.M.6
-
54
-
-
53749094183
-
CTLA-4 control over Foxp3+ regulatory T cell function
-
Wing K, Onishi Y, Prieto-Martin P, Yamaguchi T, Miyara M, Fehervari Z, et al. CTLA-4 control over Foxp3+ regulatory T cell function. Science (2008) 322(5899):271-5. doi:10.1126/science.1160062
-
(2008)
Science
, vol.322
, Issue.5899
, pp. 271-275
-
-
Wing, K.1
Onishi, Y.2
Prieto-Martin, P.3
Yamaguchi, T.4
Miyara, M.5
Fehervari, Z.6
-
55
-
-
65549136983
-
Mechanisms of FoxP3+ T regulatory cell-mediated suppression
-
Shevach EM. Mechanisms of FoxP3+ T regulatory cell-mediated suppression. Immunity (2009) 30(5):636-45. doi:10.1016/j.immuni.2009.04.010
-
(2009)
Immunity
, vol.30
, Issue.5
, pp. 636-645
-
-
Shevach, E.M.1
-
56
-
-
62549084354
-
Enhanced selection of FoxP3+ T-regulatory cells protects CTLA-4-deficient mice from CNS autoimmune disease
-
Verhagen J, Gabrysova L, Minaee S, Sabatos CA, Anderson G, Sharpe AH, et al. Enhanced selection of FoxP3+ T-regulatory cells protects CTLA-4-deficient mice from CNS autoimmune disease. Proc Natl Acad Sci U S A (2009) 106(9):3306-11. doi:10.1073/pnas.0803186106
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, Issue.9
, pp. 3306-3311
-
-
Verhagen, J.1
Gabrysova, L.2
Minaee, S.3
Sabatos, C.A.4
Anderson, G.5
Sharpe, A.H.6
-
57
-
-
79955529454
-
Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4
-
Qureshi OS, Zheng Y, Nakamura K, Attridge K, Manzotti C, Schmidt EM, et al. Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4. Science (2011) 332(6029):600-3. doi:10.1126/science.1202947
-
(2011)
Science
, vol.332
, Issue.6029
, pp. 600-603
-
-
Qureshi, O.S.1
Zheng, Y.2
Nakamura, K.3
Attridge, K.4
Manzotti, C.5
Schmidt, E.M.6
-
58
-
-
84918576077
-
Regulatory T cells control antigen-specific expansion of TFH cell number and humoral immune responses via the coreceptor CTLA-4
-
Wing JB, Ise W, Kurosaki T, Sakaguchi S. Regulatory T cells control antigen-specific expansion of TFH cell number and humoral immune responses via the coreceptor CTLA-4. Immunity (2014) 41(6):1013-25. doi:10.1016/j.immuni.2014.12.006
-
(2014)
Immunity
, vol.41
, Issue.6
, pp. 1013-1025
-
-
Wing, J.B.1
Ise, W.2
Kurosaki, T.3
Sakaguchi, S.4
-
59
-
-
84949673235
-
Deletion of CTLA-4 on regulatory T cells during adulthood leads to resistance to autoimmunity
-
Paterson AM, Lovitch SB, Sage PT, Juneja VR, Lee Y, Trombley JD, et al. Deletion of CTLA-4 on regulatory T cells during adulthood leads to resistance to autoimmunity. J Exp Med (2015) 212(10):1603-21. doi:10.1084/jem.20141030
-
(2015)
J Exp Med
, vol.212
, Issue.10
, pp. 1603-1621
-
-
Paterson, A.M.1
Lovitch, S.B.2
Sage, P.T.3
Juneja, V.R.4
Lee, Y.5
Trombley, J.D.6
-
60
-
-
33947118656
-
Increased expression of the FoxP3 functional marker of regulatory T cells following B cell depletion with rituximab in patients with lupus nephritis
-
Sfikakis PP, Souliotis VL, Fragiadaki KG, Moutsopoulos HM, Boletis JN, Theofilopoulos AN. Increased expression of the FoxP3 functional marker of regulatory T cells following B cell depletion with rituximab in patients with lupus nephritis. Clin Immunol (2007) 123(1):66-73. doi:10.1016/j.clim.2006.12.006
-
(2007)
Clin Immunol
, vol.123
, Issue.1
, pp. 66-73
-
-
Sfikakis, P.P.1
Souliotis, V.L.2
Fragiadaki, K.G.3
Moutsopoulos, H.M.4
Boletis, J.N.5
Theofilopoulos, A.N.6
-
61
-
-
84923313146
-
Engineered antigen-specific human regulatory T cells: immunosuppression of FVIII-specific T- and B-cell responses
-
Kim YC, Zhang AH, Su Y, Rieder SA, Rossi RJ, Ettinger RA, et al. Engineered antigen-specific human regulatory T cells: immunosuppression of FVIII-specific T- and B-cell responses. Blood (2015) 125(7):1107-15. doi:10.1182/blood-2014-04-566786
-
(2015)
Blood
, vol.125
, Issue.7
, pp. 1107-1115
-
-
Kim, Y.C.1
Zhang, A.H.2
Su, Y.3
Rieder, S.A.4
Rossi, R.J.5
Ettinger, R.A.6
-
62
-
-
85018027174
-
FVIII-specific human chimeric antigen receptor T-regulatory cells suppress T- and B-cell responses to FVIII
-
Yoon J, Schmidt A, Zhang AH, Konigs C, Kim YC, Scott DW. FVIII-specific human chimeric antigen receptor T-regulatory cells suppress T- and B-cell responses to FVIII. Blood (2017) 129(2):238-45. doi:10.1182/blood-2016-07-727834
-
(2017)
Blood
, vol.129
, Issue.2
, pp. 238-245
-
-
Yoon, J.1
Schmidt, A.2
Zhang, A.H.3
Konigs, C.4
Kim, Y.C.5
Scott, D.W.6
-
63
-
-
84978634373
-
T cell receptor signalling in the control of regulatory T cell differentiation and function
-
Li MO, Rudensky AY. T cell receptor signalling in the control of regulatory T cell differentiation and function. Nat Rev Immunol (2016) 16(4):220-33. doi:10.1038/nri.2016.26
-
(2016)
Nat Rev Immunol
, vol.16
, Issue.4
, pp. 220-233
-
-
Li, M.O.1
Rudensky, A.Y.2
-
64
-
-
36549030784
-
The inhibitory cytokine IL-35 contributes to regulatory T-cell function
-
Collison LW, Workman CJ, Kuo TT, Boyd K, Wang Y, Vignali KM, et al. The inhibitory cytokine IL-35 contributes to regulatory T-cell function. Nature (2007) 450(7169):566-9. doi:10.1038/nature06306
-
(2007)
Nature
, vol.450
, Issue.7169
, pp. 566-569
-
-
Collison, L.W.1
Workman, C.J.2
Kuo, T.T.3
Boyd, K.4
Wang, Y.5
Vignali, K.M.6
-
65
-
-
5644302161
-
Human T regulatory cells can use the perforin pathway to cause autologous target cell death
-
Grossman WJ, Verbsky JW, Barchet W, Colonna M, Atkinson JP, Ley TJ. Human T regulatory cells can use the perforin pathway to cause autologous target cell death. Immunity (2004) 21(4):589-601. doi:10.1016/j.immuni.2004.09.002
-
(2004)
Immunity
, vol.21
, Issue.4
, pp. 589-601
-
-
Grossman, W.J.1
Verbsky, J.W.2
Barchet, W.3
Colonna, M.4
Atkinson, J.P.5
Ley, T.J.6
-
66
-
-
67749091321
-
Infectious tolerance via the consumption of essential amino acids and mTOR signaling
-
Cobbold SP, Adams E, Farquhar CA, Nolan KF, Howie D, Lui KO, et al. Infectious tolerance via the consumption of essential amino acids and mTOR signaling. Proc Natl Acad Sci U S A (2009) 106(29):12055-60. doi:10.1073/pnas.0903919106
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, Issue.29
, pp. 12055-12060
-
-
Cobbold, S.P.1
Adams, E.2
Farquhar, C.A.3
Nolan, K.F.4
Howie, D.5
Lui, K.O.6
-
67
-
-
84970028297
-
Immunometabolism of regulatory T cells
-
Newton R, Priyadharshini B, Turka LA. Immunometabolism of regulatory T cells. Nat Immunol (2016) 17(6):618-25. doi:10.1038/ni.3466
-
(2016)
Nat Immunol
, vol.17
, Issue.6
, pp. 618-625
-
-
Newton, R.1
Priyadharshini, B.2
Turka, L.A.3
-
68
-
-
44449110691
-
Regulatory T cells inhibit dendritic cells by lymphocyte activation gene-3 engagement of MHC class II
-
Liang B, Workman C, Lee J, Chew C, Dale BM, Colonna L, et al. Regulatory T cells inhibit dendritic cells by lymphocyte activation gene-3 engagement of MHC class II. J Immunol (2008) 180(9):5916-26. doi:10.4049/jimmunol.180.9.5916
-
(2008)
J Immunol
, vol.180
, Issue.9
, pp. 5916-5926
-
-
Liang, B.1
Workman, C.2
Lee, J.3
Chew, C.4
Dale, B.M.5
Colonna, L.6
-
69
-
-
48249103057
-
FoxP3+ natural regulatory T cells preferentially form aggregates on dendritic cells in vitro and actively inhibit their maturation
-
Onishi Y, Fehervari Z, Yamaguchi T, Sakaguchi S. FoxP3+ natural regulatory T cells preferentially form aggregates on dendritic cells in vitro and actively inhibit their maturation. Proc Natl Acad Sci U S A (2008) 105(29):10113-8. doi:10.1073/pnas.0711106105
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, Issue.29
, pp. 10113-10118
-
-
Onishi, Y.1
Fehervari, Z.2
Yamaguchi, T.3
Sakaguchi, S.4
-
70
-
-
84938683119
-
The skeletal muscle environment and its role in immunity and tolerance to AAV vector-mediated gene transfer
-
Boisgerault F, Mingozzi F. The skeletal muscle environment and its role in immunity and tolerance to AAV vector-mediated gene transfer. Curr Gene Ther (2015) 15(4):381-94. doi:10.2174/1566523215666150630121750
-
(2015)
Curr Gene Ther
, vol.15
, Issue.4
, pp. 381-394
-
-
Boisgerault, F.1
Mingozzi, F.2
-
71
-
-
77957725001
-
Dystrophin immunity in Duchenne's muscular dystrophy
-
Mendell JR, Campbell K, Rodino-Klapac L, Sahenk Z, Shilling C, Lewis S, et al. Dystrophin immunity in Duchenne's muscular dystrophy. N Engl J Med (2010) 363(15):1429-37. doi:10.1056/NEJMoa1000228
-
(2010)
N Engl J Med
, vol.363
, Issue.15
, pp. 1429-1437
-
-
Mendell, J.R.1
Campbell, K.2
Rodino-Klapac, L.3
Sahenk, Z.4
Shilling, C.5
Lewis, S.6
-
72
-
-
78249253608
-
Sustained alpha-sarcoglycan gene expression after gene transfer in limb-girdle muscular dystrophy, type 2D
-
Mendell JR, Rodino-Klapac LR, Rosales XQ, Coley BD, Galloway G, Lewis S, et al. Sustained alpha-sarcoglycan gene expression after gene transfer in limb-girdle muscular dystrophy, type 2D. Ann Neurol (2010) 68(5):629-38. doi:10.1002/ana.22251
-
(2010)
Ann Neurol
, vol.68
, Issue.5
, pp. 629-638
-
-
Mendell, J.R.1
Rodino-Klapac, L.R.2
Rosales, X.Q.3
Coley, B.D.4
Galloway, G.5
Lewis, S.6
-
73
-
-
84879161464
-
Phase I/II trial of adeno-associated virus-mediated alpha-glucosidase gene therapy to the diaphragm for chronic respiratory failure in Pompe disease: initial safety and ventilatory outcomes
-
Smith BK, Collins SW, Conlon TJ, Mah CS, Lawson LA, Martin AD, et al. Phase I/II trial of adeno-associated virus-mediated alpha-glucosidase gene therapy to the diaphragm for chronic respiratory failure in Pompe disease: initial safety and ventilatory outcomes. Hum Gene Ther (2013) 24(6):630-40. doi:10.1089/hum.2012.250
-
(2013)
Hum Gene Ther
, vol.24
, Issue.6
, pp. 630-640
-
-
Smith, B.K.1
Collins, S.W.2
Conlon, T.J.3
Mah, C.S.4
Lawson, L.A.5
Martin, A.D.6
-
74
-
-
84907271281
-
Phase I/II trial of diaphragm delivery of recombinant adeno-associated virus acid alpha-glucosidase (rAAaV1-CMV-GAA) gene vector in patients with Pompe disease
-
Byrne PI, Collins S, Mah CC, Smith B, Conlon T, Martin SD, et al. Phase I/II trial of diaphragm delivery of recombinant adeno-associated virus acid alpha-glucosidase (rAAaV1-CMV-GAA) gene vector in patients with Pompe disease. Hum Gene Ther Clin Dev (2014) 25(3):134-63. doi:10.1089/humc.2014.2514
-
(2014)
Hum Gene Ther Clin Dev
, vol.25
, Issue.3
, pp. 134-163
-
-
Byrne, P.I.1
Collins, S.2
Mah, C.C.3
Smith, B.4
Conlon, T.5
Martin, S.D.6
-
75
-
-
13844264229
-
Impact of humoral immune response on distribution and efficacy of recombinant adeno-associated virus-derived acid alpha-glucosidase in a model of glycogen storage disease type II
-
Cresawn KO, Fraites TJ, Wasserfall C, Atkinson M, Lewis M, Porvasnik S, et al. Impact of humoral immune response on distribution and efficacy of recombinant adeno-associated virus-derived acid alpha-glucosidase in a model of glycogen storage disease type II. Hum Gene Ther (2005) 16(1):68-80. doi:10.1089/hum.2005.16.68
-
(2005)
Hum Gene Ther
, vol.16
, Issue.1
, pp. 68-80
-
-
Cresawn, K.O.1
Fraites, T.J.2
Wasserfall, C.3
Atkinson, M.4
Lewis, M.5
Porvasnik, S.6
-
76
-
-
84929918117
-
B-cell depletion is protective against anti-AAV capsid immune response: a human subject case study
-
Corti M, Elder M, Falk D, Lawson L, Smith B, Nayak S, et al. B-cell depletion is protective against anti-AAV capsid immune response: a human subject case study. Mol Ther Methods Clin Dev (2014) 1. doi:10.1038/mtm.2014.33
-
(2014)
Mol Ther Methods Clin Dev
, vol.1
-
-
Corti, M.1
Elder, M.2
Falk, D.3
Lawson, L.4
Smith, B.5
Nayak, S.6
-
77
-
-
77955886412
-
Lentiviral gene therapy of murine hematopoietic stem cells ameliorates the Pompe disease phenotype
-
van Til NP, Stok M, Aerts Kaya FS, de Waard MC, Farahbakhshian E, Visser TP, et al. Lentiviral gene therapy of murine hematopoietic stem cells ameliorates the Pompe disease phenotype. Blood (2010) 115(26):5329-37. doi:10.1182/blood-2009-11-252874
-
(2010)
Blood
, vol.115
, Issue.26
, pp. 5329-5337
-
-
van Til, N.P.1
Stok, M.2
Aerts Kaya, F.S.3
de Waard, M.C.4
Farahbakhshian, E.5
Visser, T.P.6
-
78
-
-
70349481529
-
Sustained transgene expression despite T lymphocyte responses in a clinical trial of rAAV1-AAT gene therapy
-
Brantly ML, Chulay JD, Wang L, Mueller C, Humphries M, Spencer LT, et al. Sustained transgene expression despite T lymphocyte responses in a clinical trial of rAAV1-AAT gene therapy. Proc Natl Acad Sci U S A (2009) 106(38):16363-8. doi:10.1073/pnas.0904514106
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, Issue.38
, pp. 16363-16368
-
-
Brantly, M.L.1
Chulay, J.D.2
Wang, L.3
Mueller, C.4
Humphries, M.5
Spencer, L.T.6
-
79
-
-
80155145248
-
Phase 2 clinical trial of a recombinant adeno-associated viral vector expressing alpha1-antitrypsin: interim results
-
Flotte TR, Trapnell BC, Humphries M, Carey B, Calcedo R, Rouhani F, et al. Phase 2 clinical trial of a recombinant adeno-associated viral vector expressing alpha1-antitrypsin: interim results. Hum Gene Ther (2011) 22(10):1239-47. doi:10.1089/hum.2011.053
-
(2011)
Hum Gene Ther
, vol.22
, Issue.10
, pp. 1239-1247
-
-
Flotte, T.R.1
Trapnell, B.C.2
Humphries, M.3
Carey, B.4
Calcedo, R.5
Rouhani, F.6
-
80
-
-
85013074473
-
Class I-restricted T-cell responses to a polymorphic peptide in a gene therapy clinical trial for alpha-1-antitrypsin deficiency
-
Calcedo R, Somanathan S, Qin Q, Betts MR, Rech AJ, Vonderheide RH, et al. Class I-restricted T-cell responses to a polymorphic peptide in a gene therapy clinical trial for alpha-1-antitrypsin deficiency. Proc Natl Acad Sci U S A (2017) 114(7):1655-9. doi:10.1073/pnas.1617726114
-
(2017)
Proc Natl Acad Sci U S A
, vol.114
, Issue.7
, pp. 1655-1659
-
-
Calcedo, R.1
Somanathan, S.2
Qin, Q.3
Betts, M.R.4
Rech, A.J.5
Vonderheide, R.H.6
-
81
-
-
85017403198
-
5 year expression and neutrophil defect repair after gene therapy in alpha-1 antitrypsin deficiency
-
Mueller C, Gernoux G, Gruntman AM, Borel F, Reeves EP, Calcedo R, et al. 5 year expression and neutrophil defect repair after gene therapy in alpha-1 antitrypsin deficiency. Mol Ther (2017) 25(6):1387-94. doi:10.1016/j.ymthe.2017.03.029
-
(2017)
Mol Ther
, vol.25
, Issue.6
, pp. 1387-1394
-
-
Mueller, C.1
Gernoux, G.2
Gruntman, A.M.3
Borel, F.4
Reeves, E.P.5
Calcedo, R.6
-
82
-
-
84890054617
-
Human Treg responses allow sustained recombinant adeno-associated virus-mediated transgene expression
-
Mueller C, Chulay JD, Trapnell BC, Humphries M, Carey B, Sandhaus RA, et al. Human Treg responses allow sustained recombinant adeno-associated virus-mediated transgene expression. J Clin Invest (2013) 123(12):5310-8. doi:10.1172/JCI70314
-
(2013)
J Clin Invest
, vol.123
, Issue.12
, pp. 5310-5318
-
-
Mueller, C.1
Chulay, J.D.2
Trapnell, B.C.3
Humphries, M.4
Carey, B.5
Sandhaus, R.A.6
-
83
-
-
84890050252
-
A special population of regulatory T cells potentiates muscle repair
-
Burzyn D, Kuswanto W, Kolodin D, Shadrach JL, Cerletti M, Jang Y, et al. A special population of regulatory T cells potentiates muscle repair. Cell (2013) 155(6):1282-95. doi:10.1016/j.cell.2013.10.054
-
(2013)
Cell
, vol.155
, Issue.6
, pp. 1282-1295
-
-
Burzyn, D.1
Kuswanto, W.2
Kolodin, D.3
Shadrach, J.L.4
Cerletti, M.5
Jang, Y.6
-
84
-
-
84908257266
-
Regulatory T cells suppress muscle inflammation and injury in muscular dystrophy
-
Villalta SA, Rosenthal W, Martinez L, Kaur A, Sparwasser T, Tidball JG, et al. Regulatory T cells suppress muscle inflammation and injury in muscular dystrophy. Sci Transl Med (2014) 6(258):258ra142. doi:10.1126/scitranslmed.3009925
-
(2014)
Sci Transl Med
, vol.6
, Issue.258
, pp. 258ra142
-
-
Villalta, S.A.1
Rosenthal, W.2
Martinez, L.3
Kaur, A.4
Sparwasser, T.5
Tidball, J.G.6
-
85
-
-
0344737700
-
CD4+CD25+ regulatory T cells inhibit immune-mediated transgene rejection
-
Gross DA, Leboeuf M, Gjata B, Danos O, Davoust J. CD4+CD25+ regulatory T cells inhibit immune-mediated transgene rejection. Blood (2003) 102(13):4326-8. doi:10.1182/blood-2003-05-1454
-
(2003)
Blood
, vol.102
, Issue.13
, pp. 4326-4328
-
-
Gross, D.A.1
Leboeuf, M.2
Gjata, B.3
Danos, O.4
Davoust, J.5
-
86
-
-
75149196666
-
Immune tolerance: what is unique about the liver
-
Tiegs G, Lohse AW. Immune tolerance: what is unique about the liver. J Autoimmun (2010) 34(1):1-6. doi:10.1016/j.jaut.2009.08.008
-
(2010)
J Autoimmun
, vol.34
, Issue.1
, pp. 1-6
-
-
Tiegs, G.1
Lohse, A.W.2
-
87
-
-
85006969361
-
Adeno-associated virus gene therapy for liver disease
-
Kattenhorn LM, Tipper CH, Stoica L, Geraghty DS, Wright TL, Clark KR, et al. Adeno-associated virus gene therapy for liver disease. Hum Gene Ther (2016) 27(12):947-61. doi:10.1089/hum.2016.160
-
(2016)
Hum Gene Ther
, vol.27
, Issue.12
, pp. 947-961
-
-
Kattenhorn, L.M.1
Tipper, C.H.2
Stoica, L.3
Geraghty, D.S.4
Wright, T.L.5
Clark, K.R.6
-
88
-
-
84990857883
-
A cure for hemophilia: the promise becomes a reality
-
Herzog RW. A cure for hemophilia: the promise becomes a reality. Mol Ther (2016) 24(9):1503-4. doi:10.1038/mt.2016.169
-
(2016)
Mol Ther
, vol.24
, Issue.9
, pp. 1503-1504
-
-
Herzog, R.W.1
-
89
-
-
85020938064
-
Complexity of immune responses to AAV transgene products-example of factor IX
-
Herzog RW. Complexity of immune responses to AAV transgene products-example of factor IX. Cell Immunol (2017). doi:10.1016/j.cellimm.2017.05.006
-
(2017)
Cell Immunol
-
-
Herzog, R.W.1
-
90
-
-
84974674181
-
Gene therapy for immune tolerance induction in hemophilia with inhibitors
-
Arruda VR, Samelson-Jones BJ. Gene therapy for immune tolerance induction in hemophilia with inhibitors. J Thromb Haemost (2016) 14(6):1121-34. doi:10.1111/jth.13331
-
(2016)
J Thromb Haemost
, vol.14
, Issue.6
, pp. 1121-1134
-
-
Arruda, V.R.1
Samelson-Jones, B.J.2
-
91
-
-
78650647673
-
Eradication of neutralizing antibodies to factor VIII in canine hemophilia A after liver gene therapy
-
Finn JD, Ozelo MC, Sabatino DE, Franck HW, Merricks EP, Crudele JM, et al. Eradication of neutralizing antibodies to factor VIII in canine hemophilia A after liver gene therapy. Blood (2010) 116(26):5842-8. doi:10.1182/blood-2010-06-288001
-
(2010)
Blood
, vol.116
, Issue.26
, pp. 5842-5848
-
-
Finn, J.D.1
Ozelo, M.C.2
Sabatino, D.E.3
Franck, H.W.4
Merricks, E.P.5
Crudele, J.M.6
-
92
-
-
84861369929
-
Transient B cell depletion or improved transgene expression by codon optimization promote tolerance to factor VIII in gene therapy
-
Sack BK, Merchant S, Markusic DM, Nathwani AC, Davidoff AM, Byrne BJ, et al. Transient B cell depletion or improved transgene expression by codon optimization promote tolerance to factor VIII in gene therapy. PLoS One (2012) 7(5):e37671. doi:10.1371/journal.pone.0037671
-
(2012)
PLoS One
, vol.7
, Issue.5
-
-
Sack, B.K.1
Merchant, S.2
Markusic, D.M.3
Nathwani, A.C.4
Davidoff, A.M.5
Byrne, B.J.6
-
93
-
-
84965086065
-
Translational data from AAV-mediated gene therapy of hemophilia B in dogs
-
Nichols T, Whitford MH, Arruda VR, Stedman HH, Kay MA, High KA. Translational data from AAV-mediated gene therapy of hemophilia B in dogs. Hum Gene Ther Clin Dev (2014). doi:10.1089/hum.2014.153
-
(2014)
Hum Gene Ther Clin Dev
-
-
Nichols, T.1
Whitford, M.H.2
Arruda, V.R.3
Stedman, H.H.4
Kay, M.A.5
High, K.A.6
-
94
-
-
84924997217
-
AAV liver expression of FIX-Padua prevents and eradicates FIX inhibitor without increasing thrombogenicity in hemophilia B dogs and mice
-
Crudele JM, Finn JD, Siner JI, Martin NB, Niemeyer GP, Zhou S, et al. AAV liver expression of FIX-Padua prevents and eradicates FIX inhibitor without increasing thrombogenicity in hemophilia B dogs and mice. Blood (2015) 125(10):1553-61. doi:10.1182/blood-2014-07-588194
-
(2015)
Blood
, vol.125
, Issue.10
, pp. 1553-1561
-
-
Crudele, J.M.1
Finn, J.D.2
Siner, J.I.3
Martin, N.B.4
Niemeyer, G.P.5
Zhou, S.6
-
95
-
-
84863480768
-
Pharmacological modulation of humoral immunity in a nonhuman primate model of AAV gene transfer for hemophilia B
-
Mingozzi F, Chen Y, Murphy SL, Edmonson SC, Tai A, Price SD, et al. Pharmacological modulation of humoral immunity in a nonhuman primate model of AAV gene transfer for hemophilia B. Mol Ther (2012) 20(7):1410-6. doi:10.1038/mt.2012.84
-
(2012)
Mol Ther
, vol.20
, Issue.7
, pp. 1410-1416
-
-
Mingozzi, F.1
Chen, Y.2
Murphy, S.L.3
Edmonson, S.C.4
Tai, A.5
Price, S.D.6
-
96
-
-
69249219148
-
Prophylactic immune tolerance induced by changing the ratio of antigen-specific effector to regulatory T cells
-
Nayak S, Cao O, Hoffman BE, Cooper M, Zhou S, Atkinson MA, et al. Prophylactic immune tolerance induced by changing the ratio of antigen-specific effector to regulatory T cells. J Thromb Haemost (2009) 7(9):1523-32. doi:10.1111/j.1538-7836.2009.03548.x
-
(2009)
J Thromb Haemost
, vol.7
, Issue.9
, pp. 1523-1532
-
-
Nayak, S.1
Cao, O.2
Hoffman, B.E.3
Cooper, M.4
Zhou, S.5
Atkinson, M.A.6
-
97
-
-
77955604541
-
Immunomodulation for inhibitors in hemophilia A: the important role of Treg cells
-
Miao CH. Immunomodulation for inhibitors in hemophilia A: the important role of Treg cells. Expert Rev Hematol (2010) 3(4):469-83. doi:10.1586/ehm.10.33
-
(2010)
Expert Rev Hematol
, vol.3
, Issue.4
, pp. 469-483
-
-
Miao, C.H.1
-
98
-
-
84948774220
-
Ex vivo expanded autologous polyclonal regulatory T cells suppress inhibitor formation in hemophilia
-
Sarkar D, Biswas M, Liao G, Seay HR, Perrin GQ, Markusic DM, et al. Ex vivo expanded autologous polyclonal regulatory T cells suppress inhibitor formation in hemophilia. Mol Ther Methods Clin Dev (2014) 1. doi:10.1038/mtm.2014.30
-
(2014)
Mol Ther Methods Clin Dev
, vol.1
-
-
Sarkar, D.1
Biswas, M.2
Liao, G.3
Seay, H.R.4
Perrin, G.Q.5
Markusic, D.M.6
-
99
-
-
84964698451
-
Synergy between rapamycin and FLT3 ligand enhances plasmacytoid dendritic cell-dependent induction of CD4+CD25+FoxP3+ Treg
-
Biswas M, Sarkar D, Kumar SR, Nayak S, Rogers GL, Markusic DM, et al. Synergy between rapamycin and FLT3 ligand enhances plasmacytoid dendritic cell-dependent induction of CD4+CD25+FoxP3+ Treg. Blood (2015) 125(19):2937-47. doi:10.1182/blood-2014-09-599266
-
(2015)
Blood
, vol.125
, Issue.19
, pp. 2937-2947
-
-
Biswas, M.1
Sarkar, D.2
Kumar, S.R.3
Nayak, S.4
Rogers, G.L.5
Markusic, D.M.6
-
100
-
-
33645240071
-
Prevention of cytotoxic T lymphocyte responses to factor IX-expressing hepatocytes by gene transfer-induced regulatory T cells
-
Dobrzynski E, Fitzgerald JC, Cao O, Mingozzi F, Wang L, Herzog RW. Prevention of cytotoxic T lymphocyte responses to factor IX-expressing hepatocytes by gene transfer-induced regulatory T cells. Proc Natl Acad Sci U S A (2006) 103(12):4592-7. doi:10.1073/pnas.0508685103
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, Issue.12
, pp. 4592-4597
-
-
Dobrzynski, E.1
Fitzgerald, J.C.2
Cao, O.3
Mingozzi, F.4
Wang, L.5
Herzog, R.W.6
-
101
-
-
34547498762
-
Induction and role of regulatory CD4+CD25+ T cells in tolerance to the transgene product following hepatic in vivo gene transfer
-
Cao O, Dobrzynski E, Wang L, Nayak S, Mingle B, Terhorst C, et al. Induction and role of regulatory CD4+CD25+ T cells in tolerance to the transgene product following hepatic in vivo gene transfer. Blood (2007) 110(4):1132-40. doi:10.1182/blood-2007-02-073304
-
(2007)
Blood
, vol.110
, Issue.4
, pp. 1132-1140
-
-
Cao, O.1
Dobrzynski, E.2
Wang, L.3
Nayak, S.4
Mingle, B.5
Terhorst, C.6
-
102
-
-
34948855431
-
Modulation of tolerance to the transgene product in a nonhuman primate model of AAV-mediated gene transfer to liver
-
Mingozzi F, Hasbrouck NC, Basner-Tschakarjan E, Edmonson SA, Hui DJ, Sabatino DE, et al. Modulation of tolerance to the transgene product in a nonhuman primate model of AAV-mediated gene transfer to liver. Blood (2007) 110(7):2334-41. doi:10.1182/blood-2007-03-080093
-
(2007)
Blood
, vol.110
, Issue.7
, pp. 2334-2341
-
-
Mingozzi, F.1
Hasbrouck, N.C.2
Basner-Tschakarjan, E.3
Edmonson, S.A.4
Hui, D.J.5
Sabatino, D.E.6
-
103
-
-
55849093638
-
Ectopic expression of neural autoantigen in mouse liver suppresses experimental autoimmune neuroinflammation by inducing antigen-specific Tregs
-
Luth S, Huber S, Schramm C, Buch T, Zander S, Stadelmann C, et al. Ectopic expression of neural autoantigen in mouse liver suppresses experimental autoimmune neuroinflammation by inducing antigen-specific Tregs. J Clin Invest (2008) 118(10):3403-10. doi:10.1172/JCI32132
-
(2008)
J Clin Invest
, vol.118
, Issue.10
, pp. 3403-3410
-
-
Luth, S.1
Huber, S.2
Schramm, C.3
Buch, T.4
Zander, S.5
Stadelmann, C.6
-
104
-
-
85029713288
-
Gene therapy-induced antigen-specific Tregs inhibit neuro-inflammation and reverse disease in a mouse model of multiple sclerosis
-
Keeler GD, Kumar S, Palaschak B, Silverberg EL, Markusic DM, Jones NT, et al. Gene therapy-induced antigen-specific Tregs inhibit neuro-inflammation and reverse disease in a mouse model of multiple sclerosis. Mol Ther (2017). doi:10.1016/j.ymthe.2017.09.001
-
(2017)
Mol Ther
-
-
Keeler, G.D.1
Kumar, S.2
Palaschak, B.3
Silverberg, E.L.4
Markusic, D.M.5
Jones, N.T.6
-
105
-
-
84930152813
-
Insulin B chain 9-23 gene transfer to hepatocytes protects from type 1 diabetes by inducing Ag-specific FoxP3+ Tregs
-
Akbarpour M, Goudy KS, Cantore A, Russo F, Sanvito F, Naldini L, et al. Insulin B chain 9-23 gene transfer to hepatocytes protects from type 1 diabetes by inducing Ag-specific FoxP3+ Tregs. Sci Transl Med (2015) 7(289):289ra281. doi:10.1126/scitranslmed.aaa3032
-
(2015)
Sci Transl Med
, vol.7
, Issue.289
, pp. 289ra281
-
-
Akbarpour, M.1
Goudy, K.S.2
Cantore, A.3
Russo, F.4
Sanvito, F.5
Naldini, L.6
-
106
-
-
65349159281
-
Immunoregulatory functions of mTOR inhibition
-
Thomson AW, Turnquist HR, Raimondi G. Immunoregulatory functions of mTOR inhibition. Nat Rev Immunol (2009) 9(5):324-37. doi:10.1038/nri2546
-
(2009)
Nat Rev Immunol
, vol.9
, Issue.5
, pp. 324-337
-
-
Thomson, A.W.1
Turnquist, H.R.2
Raimondi, G.3
-
107
-
-
0038036797
-
Rapamycin inhibits IL-4-induced dendritic cell maturation in vitro and dendritic cell mobilization and function in vivo
-
Hackstein H, Taner T, Zahorchak AF, Morelli AE, Logar AJ, Gessner A, et al. Rapamycin inhibits IL-4-induced dendritic cell maturation in vitro and dendritic cell mobilization and function in vivo. Blood (2003) 101(11):4457-63. doi:10.1182/blood-2002-11-3370
-
(2003)
Blood
, vol.101
, Issue.11
, pp. 4457-4463
-
-
Hackstein, H.1
Taner, T.2
Zahorchak, A.F.3
Morelli, A.E.4
Logar, A.J.5
Gessner, A.6
-
108
-
-
66949173728
-
The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment
-
Delgoffe GM, Kole TP, Zheng Y, Zarek PE, Matthews KL, Xiao B, et al. The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment. Immunity (2009) 30(6):832-44. doi:10.1016/j.immuni.2009.04.014
-
(2009)
Immunity
, vol.30
, Issue.6
, pp. 832-844
-
-
Delgoffe, G.M.1
Kole, T.P.2
Zheng, Y.3
Zarek, P.E.4
Matthews, K.L.5
Xiao, B.6
-
109
-
-
20444373376
-
Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells
-
Battaglia M, Stabilini A, Roncarolo MG. Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells. Blood (2005) 105(12):4743-8. doi:10.1182/blood-2004-10-3932
-
(2005)
Blood
, vol.105
, Issue.12
, pp. 4743-4748
-
-
Battaglia, M.1
Stabilini, A.2
Roncarolo, M.G.3
-
110
-
-
38049177784
-
Differential impact of mammalian target of rapamycin inhibition on CD4+CD25+Foxp3+ regulatory T cells compared with conventional CD4+ T cells
-
Zeiser R, Leveson-Gower DB, Zambricki EA, Kambham N, Beilhack A, Loh J, et al. Differential impact of mammalian target of rapamycin inhibition on CD4+CD25+Foxp3+ regulatory T cells compared with conventional CD4+ T cells. Blood (2008) 111(1):453-62. doi:10.1182/blood-2007-06-094482
-
(2008)
Blood
, vol.111
, Issue.1
, pp. 453-462
-
-
Zeiser, R.1
Leveson-Gower, D.B.2
Zambricki, E.A.3
Kambham, N.4
Beilhack, A.5
Loh, J.6
-
111
-
-
80051587138
-
Tilt balance towards regulation: evolving new strategy for treatment of hemophilia inhibitors
-
Miao CH. Tilt balance towards regulation: evolving new strategy for treatment of hemophilia inhibitors. J Thromb Haemost (2011) 9(8):1521-3. doi:10.1111/j.1538-7836.2011.04391.x
-
(2011)
J Thromb Haemost
, vol.9
, Issue.8
, pp. 1521-1523
-
-
Miao, C.H.1
-
112
-
-
84860916274
-
Prevention and reversal of antibody responses against factor IX in gene therapy for hemophilia B
-
Nayak S, Sarkar D, Perrin GQ, Moghimi B, Hoffman BE, Zhou S, et al. Prevention and reversal of antibody responses against factor IX in gene therapy for hemophilia B. Front Microbiol (2011) 2:244. doi:10.3389/fmicb.2011.00244
-
(2011)
Front Microbiol
, vol.2
, pp. 244
-
-
Nayak, S.1
Sarkar, D.2
Perrin, G.Q.3
Moghimi, B.4
Hoffman, B.E.5
Zhou, S.6
-
113
-
-
85006208454
-
Evaluation of readministration of a recombinant adeno-associated virus vector expressing acid alpha-glucosidase in Pompe disease: preclinical to clinical planning
-
Corti M, Cleaver B, Clement N, Conlon TJ, Faris KJ, Wang G, et al. Evaluation of readministration of a recombinant adeno-associated virus vector expressing acid alpha-glucosidase in Pompe disease: preclinical to clinical planning. Hum Gene Ther Clin Dev (2015) 26(3):185-93. doi:10.1089/humc.2015.068
-
(2015)
Hum Gene Ther Clin Dev
, vol.26
, Issue.3
, pp. 185-193
-
-
Corti, M.1
Cleaver, B.2
Clement, N.3
Conlon, T.J.4
Faris, K.J.5
Wang, G.6
-
114
-
-
85013386811
-
Oral tolerance induction in hemophilia B dogs fed with transplastomic lettuce
-
Herzog RW, Nichols TC, Su J, Zhang B, Sherman A, Merricks EP, et al. Oral tolerance induction in hemophilia B dogs fed with transplastomic lettuce. Mol Ther (2017) 25(2):512-22. doi:10.1016/j.ymthe.2016.11.009
-
(2017)
Mol Ther
, vol.25
, Issue.2
, pp. 512-522
-
-
Herzog, R.W.1
Nichols, T.C.2
Su, J.3
Zhang, B.4
Sherman, A.5
Merricks, E.P.6
-
115
-
-
34547788180
-
A functionally specialized population of mucosal CD103+ DCs induces FoxP3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism
-
Coombes JL, Siddiqui KR, Arancibia-Carcamo CV, Hall J, Sun CM, Belkaid Y, et al. A functionally specialized population of mucosal CD103+ DCs induces FoxP3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism. J Exp Med (2007) 204(8):1757-64. doi:10.1084/jem.20070590
-
(2007)
J Exp Med
, vol.204
, Issue.8
, pp. 1757-1764
-
-
Coombes, J.L.1
Siddiqui, K.R.2
Arancibia-Carcamo, C.V.3
Hall, J.4
Sun, C.M.5
Belkaid, Y.6
-
116
-
-
84878836808
-
Mechanism of oral tolerance induction to therapeutic proteins
-
Wang X, Sherman A, Liao G, Leong KW, Daniell H, Terhorst C, et al. Mechanism of oral tolerance induction to therapeutic proteins. Adv Drug Deliv Rev (2013) 65(6):759-73. doi:10.1016/j.addr.2012.10.013
-
(2013)
Adv Drug Deliv Rev
, vol.65
, Issue.6
, pp. 759-773
-
-
Wang, X.1
Sherman, A.2
Liao, G.3
Leong, K.W.4
Daniell, H.5
Terhorst, C.6
-
117
-
-
84927558531
-
Plant-based oral tolerance to hemophilia therapy employs a complex immune regulatory response including LAP+CD4+ T cells
-
Wang X, Su J, Sherman A, Rogers GL, Liao G, Hoffman BE, et al. Plant-based oral tolerance to hemophilia therapy employs a complex immune regulatory response including LAP+CD4+ T cells. Blood (2015) 125(15):2418-27. doi:10.1182/blood-2014-08-597070
-
(2015)
Blood
, vol.125
, Issue.15
, pp. 2418-2427
-
-
Wang, X.1
Su, J.2
Sherman, A.3
Rogers, G.L.4
Liao, G.5
Hoffman, B.E.6
-
118
-
-
79951772860
-
Intestinal tolerance requires gut homing and expansion of FoxP3+ regulatory T cells in the lamina propria
-
Hadis U, Wahl B, Schulz O, Hardtke-Wolenski M, Schippers A, Wagner N, et al. Intestinal tolerance requires gut homing and expansion of FoxP3+ regulatory T cells in the lamina propria. Immunity (2011) 34(2):237-46. doi:10.1016/j.immuni.2011.01.016
-
(2011)
Immunity
, vol.34
, Issue.2
, pp. 237-246
-
-
Hadis, U.1
Wahl, B.2
Schulz, O.3
Hardtke-Wolenski, M.4
Schippers, A.5
Wagner, N.6
-
119
-
-
84957842727
-
Oral-tolerization prevents immune responses and improves transgene persistence following gene transfer mediated by adeno-associated viral vector
-
Hardet R, Chevalier B, Dupaty L, Naimi Y, Riou G, Drouot L, et al. Oral-tolerization prevents immune responses and improves transgene persistence following gene transfer mediated by adeno-associated viral vector. Mol Ther (2016) 24(1):87-95. doi:10.1038/mt.2015.146
-
(2016)
Mol Ther
, vol.24
, Issue.1
, pp. 87-95
-
-
Hardet, R.1
Chevalier, B.2
Dupaty, L.3
Naimi, Y.4
Riou, G.5
Drouot, L.6
-
120
-
-
32644482551
-
Clinical application of expanded CD4+25+ cells
-
June CH, Blazar BR. Clinical application of expanded CD4+25+ cells. Semin Immunol (2006) 18(2):78-88. doi:10.1016/j.smim.2006.01.006
-
(2006)
Semin Immunol
, vol.18
, Issue.2
, pp. 78-88
-
-
June, C.H.1
Blazar, B.R.2
-
121
-
-
84897116999
-
Harnessing regulatory T cells for clinical use in transplantation: the end of the beginning
-
Juvet SC, Whatcott AG, Bushell AR, Wood KJ. Harnessing regulatory T cells for clinical use in transplantation: the end of the beginning. Am J Transplant (2014) 14(4):750-63. doi:10.1111/ajt.12647
-
(2014)
Am J Transplant
, vol.14
, Issue.4
, pp. 750-763
-
-
Juvet, S.C.1
Whatcott, A.G.2
Bushell, A.R.3
Wood, K.J.4
-
122
-
-
79956258982
-
Massive ex vivo expansion of human natural regulatory T cells (T(regs)) with minimal loss of in vivo functional activity
-
Hippen KL, Merkel SC, Schirm DK, Sieben CM, Sumstad D, Kadidlo DM, et al. Massive ex vivo expansion of human natural regulatory T cells (T(regs)) with minimal loss of in vivo functional activity. Sci Transl Med (2011) 3(83):83ra41. doi:10.1126/scitranslmed.3001809
-
(2011)
Sci Transl Med
, vol.3
, Issue.83
, pp. 83ra41
-
-
Hippen, K.L.1
Merkel, S.C.2
Schirm, D.K.3
Sieben, C.M.4
Sumstad, D.5
Kadidlo, D.M.6
-
123
-
-
84949753512
-
Generation of human alloantigen-specific regulatory T cells under good manufacturing practice-compliant conditions for cell therapy
-
Cherai M, Hamel Y, Baillou C, Touil S, Guillot-Delost M, Charlotte F, et al. Generation of human alloantigen-specific regulatory T cells under good manufacturing practice-compliant conditions for cell therapy. Cell Transplant (2015) 24(12):2527-40. doi:10.3727/096368914X683566
-
(2015)
Cell Transplant
, vol.24
, Issue.12
, pp. 2527-2540
-
-
Cherai, M.1
Hamel, Y.2
Baillou, C.3
Touil, S.4
Guillot-Delost, M.5
Charlotte, F.6
-
124
-
-
77956538422
-
Differentiation of type 1 T regulatory cells (Tr1) by tolerogenic DC-10 requires the IL-10-dependent ILT4/HLA-G pathway
-
Gregori S, Tomasoni D, Pacciani V, Scirpoli M, Battaglia M, Magnani CF, et al. Differentiation of type 1 T regulatory cells (Tr1) by tolerogenic DC-10 requires the IL-10-dependent ILT4/HLA-G pathway. Blood (2010) 116(6):935-44. doi:10.1182/blood-2009-07-234872
-
(2010)
Blood
, vol.116
, Issue.6
, pp. 935-944
-
-
Gregori, S.1
Tomasoni, D.2
Pacciani, V.3
Scirpoli, M.4
Battaglia, M.5
Magnani, C.F.6
-
125
-
-
84941209805
-
Generation of donor-specific T regulatory type 1 cells from patients on dialysis for cell therapy after kidney transplantation
-
Petrelli A, Tresoldi E, Mfarrej BG, Paganelli A, Spotti D, Caldara R, et al. Generation of donor-specific T regulatory type 1 cells from patients on dialysis for cell therapy after kidney transplantation. Transplantation (2015) 99(8):1582-9. doi:10.1097/TP.0000000000000751
-
(2015)
Transplantation
, vol.99
, Issue.8
, pp. 1582-1589
-
-
Petrelli, A.1
Tresoldi, E.2
Mfarrej, B.G.3
Paganelli, A.4
Spotti, D.5
Caldara, R.6
-
126
-
-
85013448421
-
Generation of donor-specific Tr1 cells to be used after kidney transplantation and definition of the timing of their in vivo infusion in the presence of immunosuppression
-
Mfarrej B, Tresoldi E, Stabilini A, Paganelli A, Caldara R, Secchi A, et al. Generation of donor-specific Tr1 cells to be used after kidney transplantation and definition of the timing of their in vivo infusion in the presence of immunosuppression. J Transl Med (2017) 15(1):40. doi:10.1186/s12967-017-1133-8
-
(2017)
J Transl Med
, vol.15
, Issue.1
, pp. 40
-
-
Mfarrej, B.1
Tresoldi, E.2
Stabilini, A.3
Paganelli, A.4
Caldara, R.5
Secchi, A.6
-
127
-
-
78751696183
-
Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics
-
Brunstein CG, Miller JS, Cao Q, McKenna DH, Hippen KL, Curtsinger J, et al. Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics. Blood (2011) 117(3):1061-70. doi:10.1182/blood-2010-07-293795
-
(2011)
Blood
, vol.117
, Issue.3
, pp. 1061-1070
-
-
Brunstein, C.G.1
Miller, J.S.2
Cao, Q.3
McKenna, D.H.4
Hippen, K.L.5
Curtsinger, J.6
-
128
-
-
79953809817
-
Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation
-
Di Ianni M, Falzetti F, Carotti A, Terenzi A, Castellino F, Bonifacio E, et al. Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation. Blood (2011) 117(14):3921-8. doi:10.1182/blood-2010-10-311894
-
(2011)
Blood
, vol.117
, Issue.14
, pp. 3921-3928
-
-
Di Ianni, M.1
Falzetti, F.2
Carotti, A.3
Terenzi, A.4
Castellino, F.5
Bonifacio, E.6
-
129
-
-
84904899365
-
HLA-haploidentical transplantation with regulatory and conventional T-cell adoptive immunotherapy prevents acute leukemia relapse
-
Martelli MF, Di Ianni M, Ruggeri L, Falzetti F, Carotti A, Terenzi A, et al. HLA-haploidentical transplantation with regulatory and conventional T-cell adoptive immunotherapy prevents acute leukemia relapse. Blood (2014) 124(4):638-44. doi:10.1182/blood-2014-03-564401
-
(2014)
Blood
, vol.124
, Issue.4
, pp. 638-644
-
-
Martelli, M.F.1
Di Ianni, M.2
Ruggeri, L.3
Falzetti, F.4
Carotti, A.5
Terenzi, A.6
-
130
-
-
84960337895
-
Umbilical cord blood-derived T regulatory cells to prevent GVHD: kinetics, toxicity profile, and clinical effect
-
Brunstein CG, Miller JS, McKenna DH, Hippen KL, DeFor TE, Sumstad D, et al. Umbilical cord blood-derived T regulatory cells to prevent GVHD: kinetics, toxicity profile, and clinical effect. Blood (2016) 127(8):1044-51. doi:10.1182/blood-2015-06-653667
-
(2016)
Blood
, vol.127
, Issue.8
, pp. 1044-1051
-
-
Brunstein, C.G.1
Miller, J.S.2
McKenna, D.H.3
Hippen, K.L.4
DeFor, T.E.5
Sumstad, D.6
-
131
-
-
84895561909
-
Immunological outcome in haploidentical-HSC transplanted patients treated with IL-10-anergized donor T cells
-
Bacchetta R, Lucarelli B, Sartirana C, Gregori S, Lupo Stanghellini MT, Miqueu P, et al. Immunological outcome in haploidentical-HSC transplanted patients treated with IL-10-anergized donor T cells. Front Immunol (2014) 5:16. doi:10.3389/fimmu.2014.00016
-
(2014)
Front Immunol
, vol.5
, pp. 16
-
-
Bacchetta, R.1
Lucarelli, B.2
Sartirana, C.3
Gregori, S.4
Lupo Stanghellini, M.T.5
Miqueu, P.6
-
132
-
-
84876012054
-
Low-dose interleukin-2 therapy restores regulatory T cell homeostasis in patients with chronic graft-versus-host disease
-
Matsuoka K, Koreth J, Kim HT, Bascug G, McDonough S, Kawano Y, et al. Low-dose interleukin-2 therapy restores regulatory T cell homeostasis in patients with chronic graft-versus-host disease. Sci Transl Med (2013) 5(179):179ra143. doi:10.1126/scitranslmed.3005265
-
(2013)
Sci Transl Med
, vol.5
, Issue.179
, pp. 179ra143
-
-
Matsuoka, K.1
Koreth, J.2
Kim, H.T.3
Bascug, G.4
McDonough, S.5
Kawano, Y.6
-
133
-
-
84898940914
-
Ultra low-dose IL-2 for GVHD prophylaxis after allogeneic hematopoietic stem cell transplantation mediates expansion of regulatory T cells without diminishing antiviral and antileukemic activity
-
Kennedy-Nasser AA, Ku S, Castillo-Caro P, Hazrat Y, Wu MF, Liu H, et al. Ultra low-dose IL-2 for GVHD prophylaxis after allogeneic hematopoietic stem cell transplantation mediates expansion of regulatory T cells without diminishing antiviral and antileukemic activity. Clin Cancer Res (2014) 20(8):2215-25. doi:10.1158/1078-0432.CCR-13-3205
-
(2014)
Clin Cancer Res
, vol.20
, Issue.8
, pp. 2215-2225
-
-
Kennedy-Nasser, A.A.1
Ku, S.2
Castillo-Caro, P.3
Hazrat, Y.4
Wu, M.F.5
Liu, H.6
-
134
-
-
84977609937
-
Efficacy, durability, and response predictors of low-dose interleukin-2 therapy for chronic graft-versus-host disease
-
Koreth J, Kim HT, Jones KT, Lange PB, Reynolds CG, Chammas MJ, et al. Efficacy, durability, and response predictors of low-dose interleukin-2 therapy for chronic graft-versus-host disease. Blood (2016) 128(1):130-7. doi:10.1182/blood-2016-02-702852
-
(2016)
Blood
, vol.128
, Issue.1
, pp. 130-137
-
-
Koreth, J.1
Kim, H.T.2
Jones, K.T.3
Lange, P.B.4
Reynolds, C.G.5
Chammas, M.J.6
-
135
-
-
84979047235
-
A pilot study of operational tolerance with a regulatory T-cell-based cell therapy in living donor liver transplantation
-
Todo S, Yamashita K, Goto R, Zaitsu M, Nagatsu A, Oura T, et al. A pilot study of operational tolerance with a regulatory T-cell-based cell therapy in living donor liver transplantation. Hepatology (2016) 64(2):632-43. doi:10.1002/hep.28459
-
(2016)
Hepatology
, vol.64
, Issue.2
, pp. 632-643
-
-
Todo, S.1
Yamashita, K.2
Goto, R.3
Zaitsu, M.4
Nagatsu, A.5
Oura, T.6
-
136
-
-
84880920749
-
The ONE study compares cell therapy products in organ transplantation: introduction to a review series on suppressive monocyte-derived cells
-
Geissler EK. The ONE study compares cell therapy products in organ transplantation: introduction to a review series on suppressive monocyte-derived cells. Transplant Res (2012) 1(1):11. doi:10.1186/2047-1440-1-11
-
(2012)
Transplant Res
, vol.1
, Issue.1
, pp. 11
-
-
Geissler, E.K.1
-
137
-
-
84899144218
-
Therapy of type 1 diabetes with CD4(+)CD25(high)CD127-regulatory T cells prolongs survival of pancreatic islets-results of one year follow-up
-
Marek-Trzonkowska N, Mysliwiec M, Dobyszuk A, Grabowska M, Derkowska I, Juscinska J, et al. Therapy of type 1 diabetes with CD4(+)CD25(high)CD127-regulatory T cells prolongs survival of pancreatic islets-results of one year follow-up. Clin Immunol (2014) 153(1):23-30. doi:10.1016/j.clim.2014.03.016
-
(2014)
Clin Immunol
, vol.153
, Issue.1
, pp. 23-30
-
-
Marek-Trzonkowska, N.1
Mysliwiec, M.2
Dobyszuk, A.3
Grabowska, M.4
Derkowska, I.5
Juscinska, J.6
-
138
-
-
84958206640
-
Antigen-specific regulatory T cells and low dose of IL-2 in treatment of type 1 diabetes
-
Pham MN, von Herrath MG, Vela JL. Antigen-specific regulatory T cells and low dose of IL-2 in treatment of type 1 diabetes. Front Immunol (2015) 6:651. doi:10.3389/fimmu.2015.00651
-
(2015)
Front Immunol
, vol.6
, pp. 651
-
-
Pham, M.N.1
von Herrath, M.G.2
Vela, J.L.3
-
139
-
-
84954443667
-
Type 1 diabetes immunotherapy using polyclonal regulatory T cells
-
Bluestone JA, Buckner JH, Fitch M, Gitelman SE, Gupta S, Hellerstein MK, et al. Type 1 diabetes immunotherapy using polyclonal regulatory T cells. Sci Transl Med (2015) 7(315):315ra189. doi:10.1126/scitranslmed.aad4134
-
(2015)
Sci Transl Med
, vol.7
, Issue.315
, pp. 315ra189
-
-
Bluestone, J.A.1
Buckner, J.H.2
Fitch, M.3
Gitelman, S.E.4
Gupta, S.5
Hellerstein, M.K.6
-
140
-
-
85016950516
-
The balance between CD8+ T cell-mediated clearance of AAV-encoded antigen in the liver and tolerance is dependent on the vector dose
-
Kumar SR, Hoffman BE, Terhorst C, de Jong YP, Herzog RW. The balance between CD8+ T cell-mediated clearance of AAV-encoded antigen in the liver and tolerance is dependent on the vector dose. Mol Ther (2017) 25(4):880-91. doi:10.1016/j.ymthe.2017.02.014
-
(2017)
Mol Ther
, vol.25
, Issue.4
, pp. 880-891
-
-
Kumar, S.R.1
Hoffman, B.E.2
Terhorst, C.3
de Jong, Y.P.4
Herzog, R.W.5
-
141
-
-
85019240457
-
Characterization of adeno-associated viral vector-mediated human factor VIII gene therapy in hemophilia A mice
-
Greig JA, Wang Q, Reicherter AL, Chen SJ, Hanlon AL, Tipper CH, et al. Characterization of adeno-associated viral vector-mediated human factor VIII gene therapy in hemophilia A mice. Hum Gene Ther (2017) 28(5):392-402. doi:10.1089/hum.2016.128
-
(2017)
Hum Gene Ther
, vol.28
, Issue.5
, pp. 392-402
-
-
Greig, J.A.1
Wang, Q.2
Reicherter, A.L.3
Chen, S.J.4
Hanlon, A.L.5
Tipper, C.H.6
-
142
-
-
73949157699
-
In vivo delivery of a microRNA-regulated transgene induces antigen-specific regulatory T cells and promotes immunologic tolerance
-
Annoni A, Brown BD, Cantore A, Sergi LS, Naldini L, Roncarolo MG. In vivo delivery of a microRNA-regulated transgene induces antigen-specific regulatory T cells and promotes immunologic tolerance. Blood (2009) 114(25):5152-61. doi:10.1182/blood-2009-04-214569
-
(2009)
Blood
, vol.114
, Issue.25
, pp. 5152-5161
-
-
Annoni, A.1
Brown, B.D.2
Cantore, A.3
Sergi, L.S.4
Naldini, L.5
Roncarolo, M.G.6
-
143
-
-
85019953446
-
A novel platform for immune tolerance induction in hemophilia A mice
-
Merlin S, Cannizzo ES, Borroni E, Bruscaggin V, Schinco P, Tulalamba W, et al. A novel platform for immune tolerance induction in hemophilia A mice. Mol Ther (2017) 25(8):1815-30. doi:10.1016/j.ymthe.2017.04.029
-
(2017)
Mol Ther
, vol.25
, Issue.8
, pp. 1815-1830
-
-
Merlin, S.1
Cannizzo, E.S.2
Borroni, E.3
Bruscaggin, V.4
Schinco, P.5
Tulalamba, W.6
-
144
-
-
77950384133
-
CD4+FOXP3+ regulatory T cells confer long-term regulation of factor VIII-specific immune responses in plasmid-mediated gene therapy-treated hemophilia mice
-
Miao CH, Harmeling BR, Ziegler SF, Yen BC, Torgerson T, Chen L, et al. CD4+FOXP3+ regulatory T cells confer long-term regulation of factor VIII-specific immune responses in plasmid-mediated gene therapy-treated hemophilia mice. Blood (2009) 114(19):4034-44. doi:10.1182/blood-2009-06-228155
-
(2009)
Blood
, vol.114
, Issue.19
, pp. 4034-4044
-
-
Miao, C.H.1
Harmeling, B.R.2
Ziegler, S.F.3
Yen, B.C.4
Torgerson, T.5
Chen, L.6
-
145
-
-
40449117736
-
In vitro expansion improves in vivo regulation by CD4+CD25+ regulatory T cells
-
Chai JG, Coe D, Chen D, Simpson E, Dyson J, Scott D. In vitro expansion improves in vivo regulation by CD4+CD25+ regulatory T cells. J Immunol (2008) 180(2):858-69. doi:10.4049/jimmunol.180.2.858
-
(2008)
J Immunol
, vol.180
, Issue.2
, pp. 858-869
-
-
Chai, J.G.1
Coe, D.2
Chen, D.3
Simpson, E.4
Dyson, J.5
Scott, D.6
-
146
-
-
84883754405
-
Generation and function of induced regulatory T cells
-
Schmitt EG, Williams CB. Generation and function of induced regulatory T cells. Front Immunol (2013) 4:152. doi:10.3389/fimmu.2013.00152
-
(2013)
Front Immunol
, vol.4
, pp. 152
-
-
Schmitt, E.G.1
Williams, C.B.2
-
147
-
-
2942642383
-
In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetes
-
Tang Q, Henriksen KJ, Bi M, Finger EB, Szot G, Ye J, et al. In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetes. J Exp Med (2004) 199(11):1455-65. doi:10.1084/jem.20040139
-
(2004)
J Exp Med
, vol.199
, Issue.11
, pp. 1455-1465
-
-
Tang, Q.1
Henriksen, K.J.2
Bi, M.3
Finger, E.B.4
Szot, G.5
Ye, J.6
-
148
-
-
33846214275
-
In vitro-expanded donor alloantigen-specific CD4+CD25+ regulatory T cells promote experimental transplantation tolerance
-
Golshayan D, Jiang S, Tsang J, Garin MI, Mottet C, Lechler RI. In vitro-expanded donor alloantigen-specific CD4+CD25+ regulatory T cells promote experimental transplantation tolerance. Blood (2007) 109(2):827-35. doi:10.1182/blood-2006-05-025460
-
(2007)
Blood
, vol.109
, Issue.2
, pp. 827-835
-
-
Golshayan, D.1
Jiang, S.2
Tsang, J.3
Garin, M.I.4
Mottet, C.5
Lechler, R.I.6
-
149
-
-
79956288367
-
Human regulatory T cells with alloantigen specificity are more potent inhibitors of alloimmune skin graft damage than polyclonal regulatory T cells
-
Sagoo P, Ali N, Garg G, Nestle FO, Lechler RI, Lombardi G. Human regulatory T cells with alloantigen specificity are more potent inhibitors of alloimmune skin graft damage than polyclonal regulatory T cells. Sci Transl Med (2011) 3(83):83ra42. doi:10.1126/scitranslmed.3002076
-
(2011)
Sci Transl Med
, vol.3
, Issue.83
, pp. 83ra42
-
-
Sagoo, P.1
Ali, N.2
Garg, G.3
Nestle, F.O.4
Lechler, R.I.5
Lombardi, G.6
-
150
-
-
81555214616
-
Ex vivo expansion of human Tregs specific for alloantigens presented directly or indirectly
-
Veerapathran A, Pidala J, Beato F, Yu XZ, Anasetti C. Ex vivo expansion of human Tregs specific for alloantigens presented directly or indirectly. Blood (2011) 118(20):5671-80. doi:10.1182/blood-2011-02-337097
-
(2011)
Blood
, vol.118
, Issue.20
, pp. 5671-5680
-
-
Veerapathran, A.1
Pidala, J.2
Beato, F.3
Yu, X.Z.4
Anasetti, C.5
-
151
-
-
84958817280
-
Successful expansion of functional and stable regulatory T cells for immunotherapy in liver transplantation
-
Safinia N, Vaikunthanathan T, Fraser H, Thirkell S, Lowe K, Blackmore L, et al. Successful expansion of functional and stable regulatory T cells for immunotherapy in liver transplantation. Oncotarget (2016) 7(7):7563-77. doi:10.18632/oncotarget.6927
-
(2016)
Oncotarget
, vol.7
, Issue.7
, pp. 7563-7577
-
-
Safinia, N.1
Vaikunthanathan, T.2
Fraser, H.3
Thirkell, S.4
Lowe, K.5
Blackmore, L.6
-
152
-
-
84905459752
-
Interleukin-12 (IL-12p70) promotes induction of highly potent Th1-like CD4(+)CD25(+) T regulatory cells that inhibit allograft rejection in unmodified recipients
-
Verma ND, Hall BM, Plain KM, Robinson CM, Boyd R, Tran GT, et al. Interleukin-12 (IL-12p70) promotes induction of highly potent Th1-like CD4(+)CD25(+) T regulatory cells that inhibit allograft rejection in unmodified recipients. Front Immunol (2014) 5:190. doi:10.3389/fimmu.2014.00190
-
(2014)
Front Immunol
, vol.5
, pp. 190
-
-
Verma, N.D.1
Hall, B.M.2
Plain, K.M.3
Robinson, C.M.4
Boyd, R.5
Tran, G.T.6
-
153
-
-
80051720194
-
Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia
-
Porter DL, Levine BL, Kalos M, Bagg A, June CH. Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia. N Engl J Med (2011) 365(8):725-33. doi:10.1056/NEJMoa1103849
-
(2011)
N Engl J Med
, vol.365
, Issue.8
, pp. 725-733
-
-
Porter, D.L.1
Levine, B.L.2
Kalos, M.3
Bagg, A.4
June, C.H.5
-
154
-
-
84876005284
-
CD19-targeted T cells rapidly induce molecular remissions in adults with chemotherapy-refractory acute lymphoblastic leukemia
-
Brentjens RJ, Davila ML, Riviere I, Park J, Wang X, Cowell LG, et al. CD19-targeted T cells rapidly induce molecular remissions in adults with chemotherapy-refractory acute lymphoblastic leukemia. Sci Transl Med (2013) 5(177):177ra138. doi:10.1126/scitranslmed.3005930
-
(2013)
Sci Transl Med
, vol.5
, Issue.177
, pp. 177ra138
-
-
Brentjens, R.J.1
Davila, M.L.2
Riviere, I.3
Park, J.4
Wang, X.5
Cowell, L.G.6
-
155
-
-
84908073316
-
Chimeric antigen receptor T cells for sustained remissions in leukemia
-
Maude SL, Frey N, Shaw PA, Aplenc R, Barrett DM, Bunin NJ, et al. Chimeric antigen receptor T cells for sustained remissions in leukemia. N Engl J Med (2014) 371(16):1507-17. doi:10.1056/NEJMoa1407222
-
(2014)
N Engl J Med
, vol.371
, Issue.16
, pp. 1507-1517
-
-
Maude, S.L.1
Frey, N.2
Shaw, P.A.3
Aplenc, R.4
Barrett, D.M.5
Bunin, N.J.6
-
156
-
-
84923019006
-
T cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: a phase 1 dose-escalation trial
-
Lee DW, Kochenderfer JN, Stetler-Stevenson M, Cui YK, Delbrook C, Feldman SA, et al. T cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: a phase 1 dose-escalation trial. Lancet (2015) 385(9967):517-28. doi:10.1016/S0140-6736(14)61403-3
-
(2015)
Lancet
, vol.385
, Issue.9967
, pp. 517-528
-
-
Lee, D.W.1
Kochenderfer, J.N.2
Stetler-Stevenson, M.3
Cui, Y.K.4
Delbrook, C.5
Feldman, S.A.6
-
157
-
-
84982150687
-
Gene therapy for "Bubble Boy"
-
Hoggatt J. Gene therapy for "Bubble Boy". Disease Cell (2016) 166(2):263. doi:10.1016/j.cell.2016.06.049
-
(2016)
Disease Cell
, vol.166
, Issue.2
, pp. 263
-
-
Hoggatt, J.1
-
158
-
-
0347785480
-
Control of regulatory T cell development by the transcription factor Foxp3
-
Hori S, Nomura T, Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science (2003) 299(5609):1057-61. doi:10.1126/science.1079490
-
(2003)
Science
, vol.299
, Issue.5609
, pp. 1057-1061
-
-
Hori, S.1
Nomura, T.2
Sakaguchi, S.3
-
159
-
-
56849097884
-
Specific immunosuppression with inducible FoxP3-transduced polyclonal T cells
-
Andersen KG, Butcher T, Betz AG. Specific immunosuppression with inducible FoxP3-transduced polyclonal T cells. PLoS Biol (2008) 6(11):e276. doi:10.1371/journal.pbio.0060276
-
(2008)
PLoS Biol
, vol.6
, Issue.11
-
-
Andersen, K.G.1
Butcher, T.2
Betz, A.G.3
-
160
-
-
80053637727
-
Resistance to regulatory T cell-mediated suppression in rheumatoid arthritis can be bypassed by ectopic foxp3 expression in pathogenic synovial T cells
-
Beavis PA, Gregory B, Green P, Cribbs AP, Kennedy A, Amjadi P, et al. Resistance to regulatory T cell-mediated suppression in rheumatoid arthritis can be bypassed by ectopic foxp3 expression in pathogenic synovial T cells. Proc Natl Acad Sci U S A (2011) 108(40):16717-22. doi:10.1073/pnas.1112722108
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, Issue.40
, pp. 16717-16722
-
-
Beavis, P.A.1
Gregory, B.2
Green, P.3
Cribbs, A.P.4
Kennedy, A.5
Amjadi, P.6
-
161
-
-
84891673531
-
CD4(+) T cells from IPEX patients convert into functional and stable regulatory T cells by FOXP3 gene transfer
-
Passerini L, Rossi Mel E, Sartirana C, Fousteri G, Bondanza A, Naldini L, et al. CD4(+) T cells from IPEX patients convert into functional and stable regulatory T cells by FOXP3 gene transfer. Sci Transl Med (2013) 5(215):215ra174. doi:10.1126/scitranslmed.3007320
-
(2013)
Sci Transl Med
, vol.5
, Issue.215
, pp. 215ra174
-
-
Passerini, L.1
Rossi Mel, E.2
Sartirana, C.3
Fousteri, G.4
Bondanza, A.5
Naldini, L.6
-
162
-
-
55849142632
-
Conferring indirect allospecificity on CD4+CD25+ Tregs by TCR gene transfer favors transplantation tolerance in mice
-
Tsang JY, Tanriver Y, Jiang S, Xue SA, Ratnasothy K, Chen D, et al. Conferring indirect allospecificity on CD4+CD25+ Tregs by TCR gene transfer favors transplantation tolerance in mice. J Clin Invest (2008) 118(11):3619-28. doi:10.1172/JCI33185
-
(2008)
J Clin Invest
, vol.118
, Issue.11
, pp. 3619-3628
-
-
Tsang, J.Y.1
Tanriver, Y.2
Jiang, S.3
Xue, S.A.4
Ratnasothy, K.5
Chen, D.6
-
163
-
-
73149093194
-
Adoptive therapy with redirected primary regulatory T cells results in antigen-specific suppression of arthritis
-
Wright GP, Notley CA, Xue SA, Bendle GM, Holler A, Schumacher TN, et al. Adoptive therapy with redirected primary regulatory T cells results in antigen-specific suppression of arthritis. Proc Natl Acad Sci U S A (2009) 106(45):19078-83. doi:10.1073/pnas.0907396106
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, Issue.45
, pp. 19078-19083
-
-
Wright, G.P.1
Notley, C.A.2
Xue, S.A.3
Bendle, G.M.4
Holler, A.5
Schumacher, T.N.6
-
164
-
-
77955380678
-
Human antigen-specific regulatory T cells generated by T cell receptor gene transfer
-
Brusko TM, Koya RC, Zhu S, Lee MR, Putnam AL, McClymont SA, et al. Human antigen-specific regulatory T cells generated by T cell receptor gene transfer. PLoS One (2010) 5(7):e11726. doi:10.1371/journal.pone.0011726
-
(2010)
PLoS One
, vol.5
, Issue.7
-
-
Brusko, T.M.1
Koya, R.C.2
Zhu, S.3
Lee, M.R.4
Putnam, A.L.5
McClymont, S.A.6
-
165
-
-
85009809566
-
Generation of human islet-specific regulatory T cells by TCR gene transfer
-
Hull CM, Nickolay LE, Estorninho M, Richardson MW, Riley JL, Peakman M, et al. Generation of human islet-specific regulatory T cells by TCR gene transfer. J Autoimmun (2017) 79:63-73. doi:10.1016/j.jaut.2017.01.001
-
(2017)
J Autoimmun
, vol.79
, pp. 63-73
-
-
Hull, C.M.1
Nickolay, L.E.2
Estorninho, M.3
Richardson, M.W.4
Riley, J.L.5
Peakman, M.6
-
166
-
-
14944371830
-
Immunotherapy of autoimmune encephalomyelitis with redirected CD4+CD25+ T lymphocytes
-
Mekala DJ, Geiger TL. Immunotherapy of autoimmune encephalomyelitis with redirected CD4+CD25+ T lymphocytes. Blood (2005) 105(5):2090-2. doi:10.1182/blood-2004-09-3579
-
(2005)
Blood
, vol.105
, Issue.5
, pp. 2090-2092
-
-
Mekala, D.J.1
Geiger, T.L.2
-
167
-
-
65249120858
-
Amelioration of colitis by genetically engineered murine regulatory T cells redirected by antigen-specific chimeric receptor
-
Elinav E, Adam N, Waks T, Eshhar Z. Amelioration of colitis by genetically engineered murine regulatory T cells redirected by antigen-specific chimeric receptor. Gastroenterology (2009) 136(5):1721-31. doi:10.1053/j.gastro.2009.01.049
-
(2009)
Gastroenterology
, vol.136
, Issue.5
, pp. 1721-1731
-
-
Elinav, E.1
Adam, N.2
Waks, T.3
Eshhar, Z.4
-
168
-
-
84861542408
-
CAR/FoxP3-engineered T regulatory cells target the CNS and suppress EAE upon intranasal delivery
-
Fransson M, Piras E, Burman J, Nilsson B, Essand M, Lu B, et al. CAR/FoxP3-engineered T regulatory cells target the CNS and suppress EAE upon intranasal delivery. J Neuroinflammation (2012) 9:112. doi:10.1186/1742-2094-9-112
-
(2012)
J Neuroinflammation
, vol.9
, pp. 112
-
-
Fransson, M.1
Piras, E.2
Burman, J.3
Nilsson, B.4
Essand, M.5
Lu, B.6
-
169
-
-
84899946297
-
Suppression of murine colitis and its associated cancer by carcinoembryonic antigen-specific regulatory T cells
-
Blat D, Zigmond E, Alteber Z, Waks T, Eshhar Z. Suppression of murine colitis and its associated cancer by carcinoembryonic antigen-specific regulatory T cells. Mol Ther (2014) 22(5):1018-28. doi:10.1038/mt.2014.41
-
(2014)
Mol Ther
, vol.22
, Issue.5
, pp. 1018-1028
-
-
Blat, D.1
Zigmond, E.2
Alteber, Z.3
Waks, T.4
Eshhar, Z.5
-
170
-
-
84964584324
-
Alloantigen-specific regulatory T cells generated with a chimeric antigen receptor
-
MacDonald KG, Hoeppli RE, Huang Q, Gillies J, Luciani DS, Orban PC, et al. Alloantigen-specific regulatory T cells generated with a chimeric antigen receptor. J Clin Invest (2016) 126(4):1413-24. doi:10.1172/JCI82771
-
(2016)
J Clin Invest
, vol.126
, Issue.4
, pp. 1413-1424
-
-
MacDonald, K.G.1
Hoeppli, R.E.2
Huang, Q.3
Gillies, J.4
Luciani, D.S.5
Orban, P.C.6
-
171
-
-
85044148609
-
Development of citrullinated-vimentin-specific CAR for targeting Tregs to treat autoimmune rheumatoid arthritis
-
Raffin C. Development of citrullinated-vimentin-specific CAR for targeting Tregs to treat autoimmune rheumatoid arthritis. J Immunol (2016) 196(1 Suppl):210.219.
-
(2016)
J Immunol
, vol.196
, Issue.1
, pp. 210.219
-
-
Raffin, C.1
-
172
-
-
85011340458
-
Expression of a chimeric antigen receptor specific for donor HLA class I enhances the potency of human regulatory T cells in preventing human skin transplant rejection
-
Boardman DA, Philippeos C, Fruhwirth GO, Ibrahim MA, Hannen RF, Cooper D, et al. Expression of a chimeric antigen receptor specific for donor HLA class I enhances the potency of human regulatory T cells in preventing human skin transplant rejection. Am J Transplant (2017) 17(4):931-43. doi:10.1111/ajt.14185
-
(2017)
Am J Transplant
, vol.17
, Issue.4
, pp. 931-943
-
-
Boardman, D.A.1
Philippeos, C.2
Fruhwirth, G.O.3
Ibrahim, M.A.4
Hannen, R.F.5
Cooper, D.6
-
173
-
-
85011961772
-
Prevention of allograft rejection by use of regulatory T cells with an MHC-specific chimeric antigen receptor
-
Noyan F, Zimmermann K, Hardtke-Wolenski M, Knoefel A, Schulde E, Geffers R, et al. Prevention of allograft rejection by use of regulatory T cells with an MHC-specific chimeric antigen receptor. Am J Transplant (2017) 17(4):917-30. doi:10.1111/ajt.14175
-
(2017)
Am J Transplant
, vol.17
, Issue.4
, pp. 917-930
-
-
Noyan, F.1
Zimmermann, K.2
Hardtke-Wolenski, M.3
Knoefel, A.4
Schulde, E.5
Geffers, R.6
-
174
-
-
85044103265
-
T cells expressing chimeric antigen receptor promote immune tolerance
-
Pierini A, Iliopoulou BP, Peiris H, Perez-Cruz M, Baker J, Hsu K, et al. T cells expressing chimeric antigen receptor promote immune tolerance. JCI Insight (2017) 2(20). doi:10.1172/jci.insight.92865
-
(2017)
JCI Insight
, vol.2
, Issue.20
-
-
Pierini, A.1
Iliopoulou, B.P.2
Peiris, H.3
Perez-Cruz, M.4
Baker, J.5
Hsu, K.6
-
175
-
-
84890181067
-
Design and development of therapies using chimeric antigen receptor-expressing T cells
-
Dotti G, Gottschalk S, Savoldo B, Brenner MK. Design and development of therapies using chimeric antigen receptor-expressing T cells. Immunol Rev (2014) 257(1):107-26. doi:10.1111/imr.12131
-
(2014)
Immunol Rev
, vol.257
, Issue.1
, pp. 107-126
-
-
Dotti, G.1
Gottschalk, S.2
Savoldo, B.3
Brenner, M.K.4
-
176
-
-
84897568616
-
Managing cytokine release syndrome associated with novel T cell-engaging therapies
-
Maude SL, Barrett D, Teachey DT, Grupp SA. Managing cytokine release syndrome associated with novel T cell-engaging therapies. Cancer J (2014) 20(2):119-22. doi:10.1097/PPO.0000000000000035
-
(2014)
Cancer J
, vol.20
, Issue.2
, pp. 119-122
-
-
Maude, S.L.1
Barrett, D.2
Teachey, D.T.3
Grupp, S.A.4
-
177
-
-
84976904277
-
Reengineering chimeric antigen receptor T cells for targeted therapy of autoimmune disease
-
Ellebrecht CT, Bhoj VG, Nace A, Choi EJ, Mao X, Cho MJ, et al. Reengineering chimeric antigen receptor T cells for targeted therapy of autoimmune disease. Science (2016) 353(6295):179-84. doi:10.1126/science.aaf6756
-
(2016)
Science
, vol.353
, Issue.6295
, pp. 179-184
-
-
Ellebrecht, C.T.1
Bhoj, V.G.2
Nace, A.3
Choi, E.J.4
Mao, X.5
Cho, M.J.6
-
178
-
-
85029376585
-
Targeting FVIII-specific B cells using BAR-transduced regulatory T cells
-
Zhang AH, Yoon JH, Kim YC, Scott DW. Targeting FVIII-specific B cells using BAR-transduced regulatory T cells. Blood (2016) 128(22):329.
-
(2016)
Blood
, vol.128
, Issue.22
, pp. 329
-
-
Zhang, A.H.1
Yoon, J.H.2
Kim, Y.C.3
Scott, D.W.4
-
179
-
-
0025058971
-
Specific unresponsiveness in rats with prolonged cardiac allograft survival after treatment with cyclosporine. III. Further characterization of the CD4+ suppressor cell and its mechanisms of action
-
Hall BM, Pearce NW, Gurley KE, Dorsch SE. Specific unresponsiveness in rats with prolonged cardiac allograft survival after treatment with cyclosporine. III. Further characterization of the CD4+ suppressor cell and its mechanisms of action. J Exp Med (1990) 171(1):141-57. doi:10.1084/jem.171.1.141
-
(1990)
J Exp Med
, vol.171
, Issue.1
, pp. 141-157
-
-
Hall, B.M.1
Pearce, N.W.2
Gurley, K.E.3
Dorsch, S.E.4
-
180
-
-
84960390391
-
Treg adoptive therapy: is more better?
-
Parmar S, Shpall EJ. Treg adoptive therapy: is more better? Blood (2016) 127(8):962-3. doi:10.1182/blood-2015-12-682492
-
(2016)
Blood
, vol.127
, Issue.8
, pp. 962-963
-
-
Parmar, S.1
Shpall, E.J.2
-
181
-
-
39849091800
-
Transient immunomodulation allows repeated injections of AAV1 and correction of muscular dystrophy in multiple muscles
-
Lorain S, Gross DA, Goyenvalle A, Danos O, Davoust J, Garcia L. Transient immunomodulation allows repeated injections of AAV1 and correction of muscular dystrophy in multiple muscles. Mol Ther (2008) 16(3):541-7. doi:10.1038/sj.mt.6300377
-
(2008)
Mol Ther
, vol.16
, Issue.3
, pp. 541-547
-
-
Lorain, S.1
Gross, D.A.2
Goyenvalle, A.3
Danos, O.4
Davoust, J.5
Garcia, L.6
|