CD4+ T cells from IPEX patients convert into functional and stable regulatory T cells by FOXP3 gene transfer

Science Translational Medicine

Volumn 5, Issue 215, 2013, Pages

  Passerini, Laura ^a   Mel, Eva Rossi ^a,b   Sartirana, Claudia ^a   Fousteri, Georgia ^c   Bondanza, Attilio ^c   Naldini, Luigi ^a,d   Roncarolo, Maria Grazia ^a,d   Bacchetta, Rosa ^a  

^a SAN RAFFAELE SCIENTIFIC INSTITUTE   (Italy)

^b UNIVERSITY OF ROME TOR VERGATA   (Italy)

^c SAN RAFFAELE HOSPITAL   (Italy)

^d VITA SALUTE SAN RAFFAELE UNIVERSITY   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 17; INTERLEUKIN 2; INTERLEUKIN 5; TRANSCRIPTION FACTOR FOXP3;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CD4+ T LYMPHOCYTE; CELLULAR IMMUNITY; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE SEVERITY; FEMALE; FOXP3 GENE; GENE EXPRESSION; GENE TRANSFER; GENETIC ENGINEERING; GRAFT VERSUS HOST REACTION; HUMAN; HUMAN CELL; IPEX SYNDROME; LYMPHOCYTE SUBPOPULATION; MEMORY T LYMPHOCYTE; MOUSE; NONHUMAN; PHENOTYPE; PHYSICAL TOLERANCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CELL PROLIFERATION; CYTOKINES; FEMALE; FLOW CYTOMETRY; FORKHEAD TRANSCRIPTION FACTORS; GENE TRANSFER TECHNIQUES; GENETIC DISEASES, X-LINKED; GENETIC ENGINEERING; GRAFT VS HOST DISEASE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; IMMUNOLOGIC MEMORY; INFLAMMATION; LEUKOCYTES, MONONUCLEAR; MICE; MICE, INBRED NOD; MICE, SCID; NEOPLASM TRANSPLANTATION; PHENOTYPE; T-LYMPHOCYTES, REGULATORY;

EID: 84891673531     PISSN: 19466234     EISSN: 19466242     Source Type: Journal    
DOI: 10.1126/scitranslmed.3007320     Document Type: Article

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