메뉴 건너뛰기




Volumn 2, Issue 5, 1996, Pages 545-550

Immune responses to transgene-encoded proteins limit the stability of gene expression after injection of replication-defective adenovims vectors

Author keywords

[No Author keywords available]

Indexed keywords

ERYTHROPOIETIN;

EID: 0029936764     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm0596-545     Document Type: Article
Times cited : (625)

References (30)
  • 2
    • 0028948924 scopus 로고
    • Adenovirus and adeno-associated virus mediated gene transfer
    • Kremer, E.J. & Perricaudet, M. Adenovirus and adeno-associated virus mediated gene transfer. Br. Med. Bull. 51, 31-44 (1995).
    • (1995) Br. Med. Bull. , vol.51 , pp. 31-44
    • Kremer, E.J.1    Perricaudet, M.2
  • 3
    • 0028237365 scopus 로고
    • Adenovirus-mediated in vivo gene transfer
    • Brody, S.L. & Crystal, R.G. Adenovirus-mediated in vivo gene transfer. Ann. N.Y. Acad. Sci. 716, 90-101 (1994).
    • (1994) Ann. N.Y. Acad. Sci. , vol.716 , pp. 90-101
    • Brody, S.L.1    Crystal, R.G.2
  • 4
    • 0028934815 scopus 로고
    • Cellular and humoral immune responses to adenoviral vectors containing factor IX gene: Tolerization of factor IX and vector antigens allows for long-term expression
    • Dai, Y. et al. Cellular and humoral immune responses to adenoviral vectors containing factor IX gene: Tolerization of factor IX and vector antigens allows for long-term expression. Proc. Natl. Acad. Sci. USA 92, 1401-1405 (1995).
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 1401-1405
    • Dai, Y.1
  • 5
    • 0027521773 scopus 로고
    • Adenovirus mediated expression of therapeutic plasma levels of human factor IX in mice
    • Smith, T.A.G. et al. Adenovirus mediated expression of therapeutic plasma levels of human factor IX in mice. Nature Genet. 5, 397-402 (1993).
    • (1993) Nature Genet. , vol.5 , pp. 397-402
    • Smith, T.A.G.1
  • 6
    • 0028234357 scopus 로고
    • In vivo correction of low density lipoprotein receptor deficiency in the Watanabe heritable hyperlipidemic rabbit with recombinant adenoviruses
    • Kozarsky, K.F. et al. In vivo correction of low density lipoprotein receptor deficiency in the Watanabe heritable hyperlipidemic rabbit with recombinant adenoviruses. J. Biol. Chem. 269, 13695-13702 (1994).
    • (1994) J. Biol. Chem. , vol.269 , pp. 13695-13702
    • Kozarsky, K.F.1
  • 8
    • 0026558496 scopus 로고
    • In vivo transfer of the human cystic fibrosis transmembrane conductance regulator gene to the airway epithelium
    • Rosenfeld, M.A. et al. In vivo transfer of the human cystic fibrosis transmembrane conductance regulator gene to the airway epithelium. Cell 68, 143-155 (1992).
    • (1992) Cell , vol.68 , pp. 143-155
    • Rosenfeld, M.A.1
  • 9
    • 0028026290 scopus 로고
    • Percutaneous transluminal gene transfer into the heart using replication-defective recombinant adenovirus
    • Barr, E. et al. Percutaneous transluminal gene transfer into the heart using replication-defective recombinant adenovirus. Gene Ther. 1, 51-58 (1994).
    • (1994) Gene Ther. , vol.1 , pp. 51-58
    • Barr, E.1
  • 10
    • 0028484704 scopus 로고
    • MHC class I-restricted cytotoxic T lymphocytes to viral antigens destroy hepatocytes in mice infected with E1-deleted recombinant adenoviruses
    • Yang, Y., Ertl. J. & Wilson J.M. MHC class I-restricted cytotoxic T lymphocytes to viral antigens destroy hepatocytes in mice infected with E1-deleted recombinant adenoviruses. Immunity 1, 433-442 (1994).
    • (1994) Immunity , vol.1 , pp. 433-442
    • Yang, Y.1    Ertl, J.2    Wilson, J.M.3
  • 11
    • 0028328261 scopus 로고
    • Cellular immunity to viral antigens limits E1-deleted adenoviruses for gene therapy
    • Yang, Y., Li, Q., Ertl, H.C. & Wilson, J.M. Cellular immunity to viral antigens limits E1-deleted adenoviruses for gene therapy. Proc. Natl. Acad. Sci. USA 91, 4407-4411 (1994).
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 4407-4411
    • Yang, Y.1    Li, Q.2    Ertl, H.C.3    Wilson, J.M.4
  • 12
    • 0028937785 scopus 로고
    • Cellular and humoral immune responses to viral antigens create barriers to lung-directed gene therapy with recombinant adenoviruses
    • Yang, Y. et al. Cellular and humoral immune responses to viral antigens create barriers to lung-directed gene therapy with recombinant adenoviruses. J. Virol. 69, 2004-2015 (1995).
    • (1995) J. Virol. , vol.69 , pp. 2004-2015
    • Yang, Y.1
  • 13
    • 0028032357 scopus 로고
    • Stable delivery of physiologic levels of recombinant erythropoietin to the systemic circulation by intramuscular injection of replication-defective adenovirus
    • Tripathy, S.K. et al. Stable delivery of physiologic levels of recombinant erythropoietin to the systemic circulation by intramuscular injection of replication-defective adenovirus. Proc. Natl. Acad. Sci. USA 91, 11557-11561 (1994).
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 11557-11561
    • Tripathy, S.K.1
  • 14
    • 0022644297 scopus 로고
    • Cloning, sequencing, and evolutionary analysis of the mouse erythropoietin gene
    • McDonald, J.D., Lin, F.K. & Goldwasser, E. Cloning, sequencing, and evolutionary analysis of the mouse erythropoietin gene. Mol. Cell. Biol. 6, 842-848 (1986).
    • (1986) Mol. Cell. Biol. , vol.6 , pp. 842-848
    • McDonald, J.D.1    Lin, F.K.2    Goldwasser, E.3
  • 15
    • 0025869934 scopus 로고
    • Specificity of the mouse cytotoxic T lymphocyte response to adenovirus 5: E1A is immunodominant in H-2b, but not in H-2d or H-2k mice
    • Rawle F.C. et al. Specificity of the mouse cytotoxic T lymphocyte response to adenovirus 5: E1A is immunodominant in H-2b, but not in H-2d or H-2k mice. J. Immun. 146, 3977-3984 (1991).
    • (1991) J. Immun. , vol.146 , pp. 3977-3984
    • Rawle, F.C.1
  • 16
    • 0028914687 scopus 로고
    • Strain related variations in adenovirally mediated transgene expression from mouse hepatocytes in vivo: Comparisons between immunocompetent and immunodeficient inbred strains
    • Barr, D. et al. Strain related variations in adenovirally mediated transgene expression from mouse hepatocytes in vivo: Comparisons between immunocompetent and immunodeficient inbred strains. Gene Ther. 2, 151-155 (1995).
    • (1995) Gene Ther. , vol.2 , pp. 151-155
    • Barr, D.1
  • 18
    • 0025373873 scopus 로고
    • Virus-induced autoantibody response to a transgenic viral antigen
    • Zinkernagel, R.M. et al. Virus-induced autoantibody response to a transgenic viral antigen. Nature 345, 68-71 (1990).
    • (1990) Nature , vol.345 , pp. 68-71
    • Zinkernagel, R.M.1
  • 19
    • 0025755292 scopus 로고
    • Ablation of "tolerance" and induction of diabetes by virus infection in viral antigen transgenic mice
    • Ohashi, P.S. et al. Ablation of "tolerance" and induction of diabetes by virus infection in viral antigen transgenic mice. Cell 65, 305-317 (1991).
    • (1991) Cell , vol.65 , pp. 305-317
    • Ohashi, P.S.1
  • 20
    • 1542702523 scopus 로고
    • Termination of acquired immunological tolerance to protein antigens following immunization with altered protein antigens
    • Weigle, W.O. Termination of acquired immunological tolerance to protein antigens following immunization with altered protein antigens. J. Exp. Med. 116, 913-928 (1962).
    • (1962) J. Exp. Med. , vol.116 , pp. 913-928
    • Weigle, W.O.1
  • 21
    • 0026750296 scopus 로고
    • Breaking T cell tolerance with foreign and self co-immunogens: A study of autoimmune B and T cell epitopes of cytochrome c
    • Mamula, M.J, Lin, R.H., Janeway, C.J. & Hardin, J.A. Breaking T cell tolerance with foreign and self co-immunogens: A study of autoimmune B and T cell epitopes of cytochrome c. J. Immun. 149, 789-795 (1992).
    • (1992) J. Immun. , vol.149 , pp. 789-795
    • Mamula, M.J.1    Lin, R.H.2    Janeway, C.J.3    Hardin, J.A.4
  • 22
    • 0025762393 scopus 로고
    • Induction of autoreactive B cells allows priming of autoreactive T cells
    • Lin, R.H., Mamula, M.J., Hardin, J.A. & Janeway, C.J. Induction of autoreactive B cells allows priming of autoreactive T cells. J. Exp. Med. 173, 1433-1439 (1991).
    • (1991) J. Exp. Med. , vol.173 , pp. 1433-1439
    • Lin, R.H.1    Mamula, M.J.2    Hardin, J.A.3    Janeway, C.J.4
  • 23
    • 0027755939 scopus 로고
    • Adenovirus-mediated transfer of the CFTR gene to lung of nonhuman primates: Biological efficacy study
    • Engelhardt, J.F. et al. Adenovirus-mediated transfer of the CFTR gene to lung of nonhuman primates: Biological efficacy study. Hum. Gene Ther. 4, 759-769 (1993).
    • (1993) Hum. Gene Ther. , vol.4 , pp. 759-769
    • Engelhardt, J.F.1
  • 24
    • 0027255704 scopus 로고
    • Direct gene transfer of human CFTR into human bronchial epithelia of xenografts with E1-deleted adenoviruses
    • Engelhardt, J.F. et al. Direct gene transfer of human CFTR into human bronchial epithelia of xenografts with E1-deleted adenoviruses. Nature Genet. 4, 27-34 (1993).
    • (1993) Nature Genet. , vol.4 , pp. 27-34
    • Engelhardt, J.F.1
  • 25
    • 0027735897 scopus 로고
    • Adenovirus-mediated transfer of the CFTR gene to lung of nonhuman primates: Toxicity study
    • Simon, R.H. et al. Adenovirus-mediated transfer of the CFTR gene to lung of nonhuman primates: Toxicity study. Hum. Gene Ther. 4, 771-780 (1993).
    • (1993) Hum. Gene Ther. , vol.4 , pp. 771-780
    • Simon, R.H.1
  • 26
    • 0028246338 scopus 로고
    • Ablation of E2A in recombinant adenoviruses improves transgene persistence and decreases inflammatory response in mouse liver
    • Engelhardt, J.F., Ye, X., Doranz, B. & Wilson, J.M. Ablation of E2A in recombinant adenoviruses improves transgene persistence and decreases inflammatory response in mouse liver. Proc. Natl. Acad. Sci. USA 91, 6196-6200 (1994).
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 6196-6200
    • Engelhardt, J.F.1    Ye, X.2    Doranz, B.3    Wilson, J.M.4
  • 27
    • 0028618419 scopus 로고
    • Prolonged transgene expression in cotton rat lung with recombinant adenoviruses defective in E2a
    • Engelhardt, J.F., Litzky, L. & Wilson, J.M. Prolonged transgene expression in cotton rat lung with recombinant adenoviruses defective in E2a. Hum. Gene Ther. 5, 1217-1229 (1994).
    • (1994) Hum. Gene Ther. , vol.5 , pp. 1217-1229
    • Engelhardt, J.F.1    Litzky, L.2    Wilson, J.M.3
  • 28
    • 0028229147 scopus 로고
    • Inactivation of E2a in recombinant adenoviruses improves the prospect for gene therapy in cystic fibrosis
    • Yang, Y. et al. Inactivation of E2a in recombinant adenoviruses improves the prospect for gene therapy in cystic fibrosis. Nature Genet. 7, 362-369 (1994).
    • (1994) Nature Genet. , vol.7 , pp. 362-369
    • Yang, Y.1
  • 29
    • 0029113869 scopus 로고
    • Long-term hepatic adenovirus-mediated gene expression in mice following CTLA4Ig administration
    • Kay, M. et al. Long-term hepatic adenovirus-mediated gene expression in mice following CTLA4Ig administration. Nature Genet. 11, 191-196 (1995).
    • (1995) Nature Genet. , vol.11 , pp. 191-196
    • Kay, M.1
  • 30
    • 0019491004 scopus 로고
    • Radioimmunoassay of erythropoietin
    • Goldwasser, E. & Sherwood, J.B. Radioimmunoassay of erythropoietin. Br. J. Haematol. 48, 359-363 (1981).
    • (1981) Br. J. Haematol. , vol.48 , pp. 359-363
    • Goldwasser, E.1    Sherwood, J.B.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.