Interleukin-12 (IL-12p70) promotes induction of highly potent Th1-like CD4+CD25+ T regulatory cells that inhibit allograft rejection in unmodified recipients

Frontiers in Immunology

Volumn 5, Issue MAY, 2014, Pages

  Verma, Nirupama Darshan ^a,c   Hall, Bruce Milne ^a   Plain, Karren Michelle ^a,d   Robinson, Catherine M ^a   Boyd, Rochelle ^a,e   Tran, Giang T ^a   Wang, Chuanmin ^b   Bishop, G Alex ^a   Hodgkinson, Suzanne J ^a  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

^b ROYAL PRINCE ALFRED HOSPITAL   (Australia)

^c ANZAC RESEARCH INSTITUTE   (Australia)

^d UNIVERSITY OF SYDNEY   (Australia)

^e MACQUARIE UNIVERSITY   (Australia)

Author keywords

Allograft rejection; Antigen specific treg; I 12p70; T regulatory cells; Th1 like treg

Indexed keywords

ALLOANTIGEN; CD4 ANTIBODY; CD45RA ANTIGEN; GAMMA INTERFERON RECEPTOR; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 12; INTERLEUKIN 12P70; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 5; MESSENGER RNA; OKT 8; TRANSCRIPTION FACTOR FOXP3;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CD4+ CD25+ T LYMPHOCYTE; CELL PROLIFERATION; CONTROLLED STUDY; GENE DOSAGE; GRAFT REJECTION; GRAFT SURVIVAL; IMMUNOFLUORESCENCE; IMMUNOSUPPRESSIVE TREATMENT; NONHUMAN; PHENOTYPE; PROTEIN EXPRESSION; RAT; REGULATORY T LYMPHOCYTE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TH1 CELL;

EID: 84905459752     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2014.00190     Document Type: Article

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