Hypothalamic ER-associated degradation regulates POMC maturation, feeding, and age-associated obesity

Journal of Clinical Investigation

Volumn 128, Issue 3, 2018, Pages 1125-1140

  Kim, Geun Hyang ^a   Shi, Guojun ^a   Somlo, Diane R M ^b,e   Haataja, Leena ^a   Song, Soobin ^b   Long, Qiaoming ^c   Nillni, Eduardo A ^d   Low, Malcolm J ^a   Arvan, Peter ^a   Myers, Martin G ^a   Qi, Ling ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b Department of Molecular Biology and Genetics   (United States)

^c SOOCHOW UNIVERSITY   (China)

^d BROWN UNIVERSITY   (United States)

^e YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA ENDORPHIN; CORTICOTROPIN; CYSTEINE; DISULFIDE; HEAT SHOCK PROTEIN 90; HORMONE PRECURSOR; INSULIN; LEPTIN; MESSENGER RNA; PROOPIOMELANOCORTIN; PROTEIN P46; PROTEIN P54; STAT3 PROTEIN; GREEN FLUORESCENT PROTEIN; PHENYLALANINE; PROTEIN; SEL1H PROTEIN, MOUSE; SYVN1 PROTEIN, MOUSE; THIOL DERIVATIVE; UBIQUITIN; UBIQUITIN PROTEIN LIGASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARCUATE NUCLEUS; ARTICLE; AXON; BROWN ADIPOSE TISSUE; DISULFIDE BOND; ENDOPLASMIC RETICULUM ASSOCIATED DEGRADATION; FEEDING BEHAVIOR; FEMALE; FOOD INTAKE; HYPERLEPTINEMIA; HYPOTHALAMUS; INSULIN BLOOD LEVEL; LIVER; MALE; METABOLIC RATE; MOUSE; MUTATION; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN PROCESSING; UBIQUITINATION; WHITE ADIPOSE TISSUE; ZONA INCERTA; ANIMAL; BLOOD; C57BL MOUSE; CHEMISTRY; ENDOPLASMIC RETICULUM; GENETICS; HUMAN; INFLAMMATION; METABOLISM; NERVE CELL; PATHOLOGY;

ANIMALS; AXONS; CYSTEINE; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM-ASSOCIATED DEGRADATION; FEEDING BEHAVIOR; FEMALE; GREEN FLUORESCENT PROTEINS; HUMANS; HYPOTHALAMUS; INFLAMMATION; LEPTIN; MALE; MICE; MICE, INBRED C57BL; MUTATION; NEURONS; OBESITY; PHENYLALANINE; PRO-OPIOMELANOCORTIN; PROTEINS; SULFHYDRYL COMPOUNDS; UBIQUITIN; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

EID: 85042789551     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI96420     Document Type: Article

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