The ER-associated degradation adaptor protein sel1l regulates LPL secretion and lipid metabolism

Cell Metabolism

Volumn 20, Issue 3, 2014, Pages 458-470

  Sha, Haibo ^a   Sun, Shengyi ^a   Francisco, Adam B ^a   Ehrhardt, Nicole ^b   Xue, Zhen ^a   Liu, Lei ^a   Lawrence, Peter ^a   Mattijssen, Frits ^c   Guber, Robert D ^a   Panhwar, Muhammad S ^d   Brenna, J Thomas ^a   Shi, Hang ^e   Xue, Bingzhong ^e   Kersten, Sander ^a,c   Bensadoun, André ^a   Péterfy, Miklós ^b,f   Long, Qiaoming ^g   Qi, Ling ^a  

^a Department of Obstetrics Gynecology   (United States)

^b CEDARS SINAI MEDICAL CENTER   (United States)

^c WAGENINGEN UNIVERSITY   (Netherlands)

^d WEILL CORNELL MEDICAL COLLEGE   (Qatar)

^e GEORGIA STATE UNIVERSITY   (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

^g MEDICAL COLLEGE OF SOOCHOW UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; LIPASE MATURATION FACTOR 1; LIPID; LIPOPROTEIN LIPASE; MEMBRANE PROTEIN; SEL 1 SUPPRESSOR OF LIN 12 LIKE PROTEIN; UNCLASSIFIED DRUG; LMF1 PROTEIN, MOUSE; PROTEIN; PROTEIN AGGREGATE; SEL1H PROTEIN, MOUSE;

ADIPOCYTE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; AUTOPHAGY; CONTROLLED STUDY; ENDOPLASMIC RETICULUM ASSOCIATED DEGRADATION; ENDOPLASMIC RETICULUM HOMEOSTASIS; ENZYME RELEASE; EXPERIMENTAL OBESITY; FEMALE; HEART MUSCLE CELL; HOMEOSTASIS; HYPERTRIGLYCERIDEMIA; LIPID METABOLISM; MACROPHAGE; MOUSE; NONHUMAN; PROTEIN AGGREGATION; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; REGULATORY MECHANISM; ADVERSE EFFECTS; ANIMAL; C57BL MOUSE; CELL CULTURE; CHEMISTRY; GENE DELETION; GENETICS; HYPERGLYCEMIA; LIPID DIET; MALE; METABOLISM; OBESITY; PROTEIN MULTIMERIZATION;

ADIPOCYTES; ANIMALS; CELLS, CULTURED; DIET, HIGH-FAT; ENDOPLASMIC RETICULUM-ASSOCIATED DEGRADATION; FEMALE; GENE DELETION; HYPERGLYCEMIA; LIPID METABOLISM; LIPOPROTEIN LIPASE; MALE; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; OBESITY; PROTEIN AGGREGATES; PROTEIN MULTIMERIZATION; PROTEINS;

EID: 84913536702     PISSN: 15504131     EISSN: 19327420     Source Type: Journal    
DOI: 10.1016/j.cmet.2014.06.015     Document Type: Article

References (47)

1. O. Ben-Zeev, M.H. Doolittle, R.C. Davis, J. Elovson, and M.C. Schotz Maturation of lipoprotein lipase. Expression of full catalytic activity requires glucose trimming but not translocation to the cis-Golgi compartment J. Biol. Chem. 267 1992 6219 6227
2. O. Ben-Zeev, H.Z. Mao, and M.H. Doolittle Maturation of lipoprotein lipase in the endoplasmic reticulum. Concurrent formation of functional dimers and inactive aggregates J. Biol. Chem. 277 2002 10727 10738
3. R. Bernasconi, C. Galli, V. Calanca, T. Nakajima, and M. Molinari Stringent requirement for HRD1, SEL1L, and OS-9/XTP3-B for disposal of ERAD-LS substrates J. Cell Biol. 188 2010 223 235
4. V. Briquet-Laugier, O. Ben-Zeev, and M.H. Doolittle Determining lipoprotein lipase and hepatic lipase activity using radiolabeled substrates Methods Mol. Biol. 109 1999 81 94
5. D.C. Chan, J. Pang, G. Romic, and G.F. Watts Postprandial hypertriglyceridemia and cardiovascular disease: current and future therapies Curr. Atheroscler. Rep. 15 2013 309
6. F. Chiti, and C.M. Dobson Protein misfolding, functional amyloid, and human disease Annu. Rev. Biochem. 75 2006 333 366
7. W. Dijk, and S. Kersten Regulation of lipoprotein lipase by Angptl4 Trends Endocrinol. Metab. 25 2014 146 155
8. M.H. Doolittle, and M. Peterfy Mechanisms of lipase maturation Clin. Lipidol. 5 2010 71 85
9. J. Eguchi, X. Wang, S. Yu, E.E. Kershaw, P.C. Chiu, J. Dushay, J.L. Estall, U. Klein, E. Maratos-Flier, and E.D. Rosen Transcriptional control of adipose lipid handling by IRF4 Cell Metab. 13 2011 249 259
10. A.B. Francisco, R. Singh, S. Li, A.K. Vani, L. Yang, R.J. Munroe, G. Diaferia, M. Cardano, I. Biunno, and L. Qi Deficiency of suppressor enhancer Lin12 1 like (SEL1L) in mice leads to systemic endoplasmic reticulum stress and embryonic lethality J. Biol. Chem. 285 2010 13694 13703
11. E. Fujita, Y. Kouroku, A. Isoai, H. Kumagai, A. Misutani, C. Matsuda, Y.K. Hayashi, and T. Momoi Two endoplasmic reticulum-associated degradation (ERAD) systems for the novel variant of the mutant dysferlin: ubiquitin/proteasome ERAD(I) and autophagy/lysosome ERAD(II) Hum. Mol. Genet. 16 2007 618 629
12. I. Garcia-Arcos, Y. Hiyama, K. Drosatos, K.G. Bharadwaj, Y. Hu, N.H. Son, S.M. O'Byrne, C.L. Chang, R.J. Deckelbaum, and M. Takahashi Adipose-specific lipoprotein lipase deficiency more profoundly affects brown than white fat biology J. Biol. Chem. 288 2013 14046 14058
13. R.G. Gardner, G.M. Swarbrick, N.W. Bays, S.R. Cronin, S. Wilhovsky, L. Seelig, C. Kim, and R.Y. Hampton Endoplasmic reticulum degradation requires lumen to cytosol signaling. Transmembrane control of Hrd1p by Hrd3p J. Cell Biol. 151 2000 69 82
14. B. Grant, and I. Greenwald The Caenorhabditis elegans sel-1 gene, a negative regulator of lin-12 and glp-1, encodes a predicted extracellular protein Genetics 143 1996 237 247
15. R.Y. Hampton, R.G. Gardner, and J. Rine Role of 26S proteasome and HRD genes in the degradation of 3-hydroxy-3-methylglutaryl-CoA reductase, an integral endoplasmic reticulum membrane protein Mol. Biol. Cell 7 1996 2029 2044
16. M.G. Hartman, D. Lu, M.L. Kim, G.J. Kociba, T. Shukri, J. Buteau, X. Wang, W.L. Frankel, D. Guttridge, and M. Prentki Role for activating transcription factor 3 in stress-induced beta-cell apoptosis Mol. Cell. Biol. 24 2004 5721 5732
17. C. Hetz The unfolded protein response: controlling cell fate decisions under ER stress and beyond Nat. Rev. Mol. Cell Biol. 13 2012 89 102
18. T. Hidvegi, M. Ewing, P. Hale, C. Dippold, C. Beckett, C. Kemp, N. Maurice, A. Mukherjee, C. Goldbach, and S. Watkins An autophagy-enhancing drug promotes degradation of mutant alpha1-antitrypsin Z and reduces hepatic fibrosis Science 329 2010 229 232
19. G.S. Hotamisligil Endoplasmic reticulum stress and the inflammatory basis of metabolic disease Cell 140 2010 900 917
20. S.A. Houck, S. Singh, and D.M. Cyr Cellular responses to misfolded proteins and protein aggregates Methods Mol. Biol. 832 2012 455 461
21. S.A. Houck, H.Y. Ren, V.J. Madden, J.N. Bonner, M.P. Conlin, J.A. Janovick, P.M. Conn, and D.M. Cyr Quality control autophagy degrades soluble ERAD-resistant conformers of the misfolded membrane protein GnRHR Mol. Cell 54 2014 166 179
22. L. Lichtenstein, J.F. Berbée, S.J. van Dijk, K.W. van Dijk, A. Bensadoun, I.P. Kema, P.J. Voshol, M. Müller, P.C. Rensen, and S. Kersten Angptl4 upregulates cholesterol synthesis in liver via inhibition of LPL- and HL-dependent hepatic cholesterol uptake Arterioscler. Thromb. Vasc. Biol. 27 2007 2420 2427
23. G. Liu, G. Bengtsson-Olivecrona, and T. Olivecrona Assembly of lipoprotein lipase in perfused guinea-pig hearts Biochem. J. 292 1993 277 282
24. T.F. Liu, J.J. Tang, P.S. Li, Y. Shen, J.G. Li, H.H. Miao, B.L. Li, and B.L. Song Ablation of gp78 in liver improves hyperlipidemia and insulin resistance by inhibiting SREBP to decrease lipid biosynthesis Cell Metab. 16 2012 213 225
25. B. Mueller, B.N. Lilley, and H.L. Ploegh SEL1L, the homologue of yeast Hrd3p, is involved in protein dislocation from the mammalian ER J. Cell Biol. 175 2006 261 270
26. B. Mueller, E.J. Klemm, E. Spooner, J.H. Claessen, and H.L. Ploegh SEL1L nucleates a protein complex required for dislocation of misfolded glycoproteins Proc. Natl. Acad. Sci. USA 105 2008 12325 12330
27. Y. Ohsaki, J. Cheng, A. Fujita, T. Tokumoto, and T. Fujimoto Cytoplasmic lipid droplets are sites of convergence of proteasomal and autophagic degradation of apolipoprotein B Mol. Biol. Cell 17 2006 2674 2683
28. J.A. Olzmann, R.R. Kopito, and J.C. Christianson The mammalian endoplasmic reticulum-associated degradation system Cold Spring Harb. Perspect. Biol. 5 2013 5
29. M. Péterfy Lipase maturation factor 1: a lipase chaperone involved in lipid metabolism Biochim. Biophys. Acta 1821 2012 790 794
30. M. Péterfy, O. Ben-Zeev, H.Z. Mao, D. Weissglas-Volkov, B.E. Aouizerat, C.R. Pullinger, P.H. Frost, J.P. Kane, M.J. Malloy, and K. Reue Mutations in LMF1 cause combined lipase deficiency and severe hypertriglyceridemia Nat. Genet. 39 2007 1483 1487
31. W. Qiu, J. Zhang, M.J. Dekker, H. Wang, J. Huang, J.H. Brumell, and K. Adeli Hepatic autophagy mediates endoplasmic reticulum stress-induced degradation of misfolded apolipoprotein B Hepatology 53 2011 1515 1525
32. D.T. Rutkowski, and R.J. Kaufman That which does not kill me makes me stronger: adapting to chronic ER stress Trends Biochem. Sci. 32 2007 469 476
33. A. Sakakibara, M. Furuse, M. Saitou, Y. Ando-Akatsuka, and S. Tsukita Possible involvement of phosphorylation of occludin in tight junction formation J. Cell Biol. 137 1997 1393 1401
34. H. Sha, L. Yang, M. Liu, S. Xia, Y. Liu, F. Liu, S. Kersten, and L. Qi Adipocyte spliced form of X-box-binding protein 1 promotes adiponectin multimerization and systemic glucose homeostasis Diabetes 63 2014 867 879
35. R. Singh, and A.M. Cuervo Lipophagy: connecting autophagy and lipid metabolism Int. J. Cell Biol. 2012 2012 282041
36. M.H. Smith, H.L. Ploegh, and J.S. Weissman Road to ruin: targeting proteins for degradation in the endoplasmic reticulum Science 334 2011 1086 1090
37. S. Sun, S. Xia, Y. Ji, S. Kersten, and L. Qi The ATP-P2X7 signaling axis is dispensable for obesity-associated inflammasome activation in adipose tissue Diabetes 61 2012 1471 1478
38. S. Sun, G. Shi, X. Han, A.B. Francisco, Y. Ji, N. Mendonça, X. Liu, J.W. Locasale, K.W. Simpson, and G.E. Duhamel Sel1L is indispensable for mammalian endoplasmic reticulum-associated degradation, endoplasmic reticulum homeostasis, and survival Proc. Natl. Acad. Sci. USA 111 2014 E582 E591
39. M. Sundaram, and I. Greenwald Suppressors of a lin-12 hypomorph define genes that interact with both lin-12 and glp-1 in Caenorhabditis elegans Genetics 135 1993 765 783
40. J.H. Teckman, and D.H. Perlmutter Retention of mutant alpha(1)-antitrypsin Z in endoplasmic reticulum is associated with an autophagic response Am. J. Physiol. Gastrointest. Liver Physiol. 279 2000 G961 G974
41. C. Vannier, and G. Ailhaud Biosynthesis of lipoprotein lipase in cultured mouse adipocytes. II. Processing, subunit assembly, and intracellular transport J. Biol. Chem. 264 1989 13206 13216
42. H. Wang, and R.H. Eckel Lipoprotein lipase: from gene to obesity Am. J. Physiol. Endocrinol. Metab. 297 2009 E271 E288
43. Q. Wang, Y. Liu, N. Soetandyo, K. Baek, R. Hegde, and Y. Ye A ubiquitin ligase-associated chaperone holdase maintains polypeptides in soluble states for proteasome degradation Mol. Cell 42 2011 758 770
44. M.M. Weinstein, L. Yin, A.P. Beigneux, B.S. Davies, P. Gin, K. Estrada, K. Melford, J.R. Bishop, J.D. Esko, and G.M. Dallinga-Thie Abnormal patterns of lipoprotein lipase release into the plasma in GPIHBP1-deficient mice J. Biol. Chem. 283 2008 34511 34518
45. K.J. Williams Molecular processes that handle - and mishandle - dietary lipids J. Clin. Invest. 118 2008 3247 3259
46. T. Wu, F. Zhao, B. Gao, C. Tan, N. Yagishita, T. Nakajima, P.K. Wong, E. Chapman, D. Fang, and D.D. Zhang Hrd1 suppresses Nrf2-mediated cellular protection during liver cirrhosis Genes Dev. 28 2014 708 722
47. R. Ye, D.Y. Jung, J.Y. Jun, J. Li, S. Luo, H.J. Ko, J.K. Kim, and A.S. Lee Grp78 heterozygosity promotes adaptive unfolded protein response and attenuates diet-induced obesity and insulin resistance Diabetes 59 2010 6 16