-
1
-
-
84855393059
-
Proprotein convertases in health and disease
-
Artenstein AW & Opal SM 2011 Proprotein convertases in health and disease. New England Journal of Medicine 365 2507-2518. (doi:10.1056/NEJMra1106700)
-
(2011)
New England Journal of Medicine
, vol.365
, pp. 2507-2518
-
-
Artenstein, A.W.1
Opal, S.M.2
-
2
-
-
0025762119
-
PC1 and PC2 are proprotein convertases capable of cleaving proopiomelanocortin at distinct pairs of basic residues
-
Benjannet S, Rondeau N, Day R, Chretien M & Seidah NG 1991 PC1 and PC2 are proprotein convertases capable of cleaving proopiomelanocortin at distinct pairs of basic residues. PNAS 88 3564-3568.
-
(1991)
PNAS
, vol.88
, pp. 3564-3568
-
-
Benjannet, S.1
Rondeau, N.2
Day, R.3
Chretien, M.4
Seidah, N.G.5
-
4
-
-
78651150366
-
Isolation and properties of a new, biologically active peptide from sheep pituitary glands
-
Birk Y & Li CH 1964 Isolation and properties of a new, biologically active peptide from sheep pituitary glands. Journal of Biological Chemistry 239 1048-1052.
-
(1964)
Journal of Biological Chemistry
, vol.239
, pp. 1048-1052
-
-
Birk, Y.1
Li, C.H.2
-
5
-
-
0026398206
-
Prohormone-converting enzymes: Regulation and evaluation of function using antisense RNA
-
Bloomquist BT, Eipper BA & Mains RE 1991 Prohormone-converting enzymes: regulation and evaluation of function using antisense RNA. Molecular Endocrinology 5 2014-2024.
-
(1991)
Molecular Endocrinology
, vol.5
, pp. 2014-2024
-
-
Bloomquist, B.T.1
Eipper, B.A.2
Mains, R.E.3
-
6
-
-
0014411801
-
Porcine proinsulin: Characterization and amino acid sequence
-
Chance RE, Ellis RM & Bromer WW 1968 Porcine proinsulin: characterization and amino acid sequence. Science 161 165-167.
-
(1968)
Science
, vol.161
, pp. 165-167
-
-
Chance, R.E.1
Ellis, R.M.2
Bromer, W.W.3
-
7
-
-
84866928259
-
My road to Damascus: How I converted to the prohormone theory and the proprotein convertases
-
Chretien M 2012 My road to Damascus: how I converted to the prohormone theory and the proprotein convertases. Biochemistry and Cell Biology 90 750-768. (doi:10.1139/o2012-031)
-
(2012)
Biochemistry and Cell Biology
, vol.90
, pp. 750-768
-
-
Chretien, M.1
-
8
-
-
0014107316
-
Isolation, purification, and characterization of gamma-lipotropic hormone from sheep pituitary glands
-
Chretien M & Li CH 1967 Isolation, purification, and characterization of gamma-lipotropic hormone from sheep pituitary glands. Canadian Journal of Biochemistry 45 1163-1174.
-
(1967)
Canadian Journal of Biochemistry
, vol.45
, pp. 1163-1174
-
-
Chretien, M.1
Li, C.H.2
-
9
-
-
0017102311
-
Isolation of peptides with opiate activity from sheep and human pituitaries: Relationship to beta-lipotropin
-
Chretien M, Benjannet S, Dragon N, Seidah NG & Lis M 1976a Isolation of peptides with opiate activity from sheep and human pituitaries: relationship to beta-lipotropin. Biochemical and Biophysical Research Communications 72 472-478.
-
(1976)
Biochemical and Biophysical Research Communications
, vol.72
, pp. 472-478
-
-
Chretien, M.1
Benjannet, S.2
Dragon, N.3
Seidah, N.G.4
Lis, M.5
-
11
-
-
0018571281
-
From beta-lipotropin to beta-endorphin and 'pro-opio-melanocortin'
-
Chretien M, Benjannet S, Gossard F, Gianoulakis C, Crine P, Lis M & Seidah NG 1979 From beta-lipotropin to beta-endorphin and 'pro-opio-melanocortin'. Canadian Journal of Biochemistry 57 1111-1121.
-
(1979)
Canadian Journal of Biochemistry
, vol.57
, pp. 1111-1121
-
-
Chretien, M.1
Benjannet, S.2
Gossard, F.3
Gianoulakis, C.4
Crine, P.5
Lis, M.6
Seidah, N.G.7
-
13
-
-
0024805307
-
Functional diversity of bioactive peptides in the nervous system itself: "how the brain may understand"
-
Chretien M, Sikstrom RA, Lazure C, Mbikay M & Seidah NG 1989 Functional diversity of bioactive peptides in the nervous system itself: "how the brain may understand". Bioscience Reports 9 693-700.
-
(1989)
Bioscience Reports
, vol.9
, pp. 693-700
-
-
Chretien, M.1
Sikstrom, R.A.2
Lazure, C.3
Mbikay, M.4
Seidah, N.G.5
-
15
-
-
0028861480
-
Endoproteolytic cleavage of its propeptide is a prerequisite for efficient transport of furin out of the endoplasmic reticulum
-
Creemers JW, Vey M, Schafer W, Ayoubi TA, Roebroek AJ, Klenk HD, Garten W & Van de Ven WJ 1995 Endoproteolytic cleavage of its propeptide is a prerequisite for efficient transport of furin out of the endoplasmic reticulum. Journal of Biological Chemistry 270 2695-2702.
-
(1995)
Journal of Biological Chemistry
, vol.270
, pp. 2695-2702
-
-
Creemers, J.W.1
Vey, M.2
Schafer, W.3
Ayoubi, T.A.4
Roebroek, A.J.5
Klenk, H.D.6
Garten, W.7
Van de Ven, W.J.8
-
16
-
-
0017579124
-
In vitro biosynthesis of beta-endorphin in pituitary glands
-
Crine P, Benjannet S, Seidah NG, Lis M & Chretien M 1977 In vitro biosynthesis of beta-endorphin in pituitary glands. PNAS 74 1403-1406.
-
(1977)
PNAS
, vol.74
, pp. 1403-1406
-
-
Crine, P.1
Benjannet, S.2
Seidah, N.G.3
Lis, M.4
Chretien, M.5
-
17
-
-
0018189453
-
Biosynthesis of beta-endorphin from betalipotropin and a larger molecular weight precursor in rat pars intermedia
-
Crine P, Gianoulakis C, Seidah NG, Gossard F, Pezalla PD, Lis M & Chretien M 1978 Biosynthesis of beta-endorphin from betalipotropin and a larger molecular weight precursor in rat pars intermedia. PNAS 75 4719-4723.
-
(1978)
PNAS
, vol.75
, pp. 4719-4723
-
-
Crine, P.1
Gianoulakis, C.2
Seidah, N.G.3
Gossard, F.4
Pezalla, P.D.5
Lis, M.6
Chretien, M.7
-
18
-
-
0000156413
-
The basophil adenomas of the pituitary body and their clinical manifestations
-
Cushing H 1932 The basophil adenomas of the pituitary body and their clinical manifestations. Bulletin of the Johns Hopkins Hospital 30 137-195.
-
(1932)
Bulletin of the Johns Hopkins Hospital
, vol.30
, pp. 137-195
-
-
Cushing, H.1
-
19
-
-
0023408598
-
Proteolytic conversion of proinsulin into insulin. Identification of a Ca2+-dependent acidic endopeptidase in isolated insulin-secretory granules
-
Davidson HW, Peshavaria M & Hutton JC 1987 Proteolytic conversion of proinsulin into insulin. Identification of a Ca2+-dependent acidic endopeptidase in isolated insulin-secretory granules. Biochemical Journal 246 279-286.
-
(1987)
Biochemical Journal
, vol.246
, pp. 279-286
-
-
Davidson, H.W.1
Peshavaria, M.2
Hutton, J.C.3
-
20
-
-
0026609102
-
Distribution and regulation of the prohormone convertases PC1 and PC2 in the rat pituitary
-
Day R, Schafer MK, Watson SJ, Chretien M & Seidah NG 1992 Distribution and regulation of the prohormone convertases PC1 and PC2 in the rat pituitary. Molecular Endocrinology 6 485-497.
-
(1992)
Molecular Endocrinology
, vol.6
, pp. 485-497
-
-
Day, R.1
Schafer, M.K.2
Watson, S.J.3
Chretien, M.4
Seidah, N.G.5
-
22
-
-
0021196999
-
Polyprotein gene expression: Generation of diversity of neuroendocrine peptides
-
Douglass J, Civelli O & Herbert E 1984 Polyprotein gene expression: generation of diversity of neuroendocrine peptides. Annual Review of Biochemistry 53 665-715. (doi:10.1146/annurev.bi.53.070184.003313)
-
(1984)
Annual Review of Biochemistry
, vol.53
, pp. 665-715
-
-
Douglass, J.1
Civelli, O.2
Herbert, E.3
-
23
-
-
0019180771
-
Most of the coding region of rat ACTH beta-LPH precursor gene lacks intervening sequences
-
Drouin J & Goodman HM 1980 Most of the coding region of rat ACTH beta-LPH precursor gene lacks intervening sequences. Nature 288 610-613.
-
(1980)
Nature
, vol.288
, pp. 610-613
-
-
Drouin, J.1
Goodman, H.M.2
-
24
-
-
0001433809
-
Method for determination of the amino acid sequence in peptides
-
Edman P 1950 Method for determination of the amino acid sequence in peptides. Acta Chemica Scandinavica 4 283-293.
-
(1950)
Acta Chemica Scandinavica
, vol.4
, pp. 283-293
-
-
Edman, P.1
-
25
-
-
0019268826
-
Structure and biosynthesis of proadrenocorticotropin/ endorphin and related peptides
-
Eipper BA & Mains RE 1980 Structure and biosynthesis of proadrenocorticotropin/ endorphin and related peptides. Endocrine Reviews 1 1-27. (doi:10.1210/edrv-1-1-1)
-
(1980)
Endocrine Reviews
, vol.1
, pp. 1-27
-
-
Eipper, B.A.1
Mains, R.E.2
-
26
-
-
0017127902
-
High molecular weight forms of adrenocorticotropic hormone are glycoproteins
-
Eipper BA, Mains RE & Guenzi D 1976 High molecular weight forms of adrenocorticotropic hormone are glycoproteins. Journal of Biological Chemistry 251 4121-4126.
-
(1976)
Journal of Biological Chemistry
, vol.251
, pp. 4121-4126
-
-
Eipper, B.A.1
Mains, R.E.2
Guenzi, D.3
-
27
-
-
0026514908
-
The biosynthesis of neuropeptides: Peptide alpha-amidation
-
Eipper BA, Stoffers DA & Mains RE 1992 The biosynthesis of neuropeptides: peptide alpha-amidation. Annual Review of Neuroscience 15 57-85. (doi:10.1146/annurev.ne.15.030192.000421).
-
(1992)
Annual Review of Neuroscience
, vol.15
, pp. 57-85
-
-
Eipper, B.A.1
Stoffers, D.A.2
Mains, R.E.3
-
29
-
-
0000611868
-
Yeast prohormone processing enzyme (KEX2 gene product) is a Ca2+-dependent serine protease
-
Fuller RS, Brake A & Thorner J 1989a Yeast prohormone processing enzyme (KEX2 gene product) is a Ca2+-dependent serine protease. PNAS 86 1434-1438.
-
(1989)
PNAS
, vol.86
, pp. 1434-1438
-
-
Fuller, R.S.1
Brake, A.2
Thorner, J.3
-
30
-
-
0024425494
-
Intracellular targeting and structural conservation of a prohormone-processing endoprotease
-
Fuller RS, Brake AJ & Thorner J 1989b Intracellular targeting and structural conservation of a prohormone-processing endoprotease. Science 246 482-486.
-
(1989)
Science
, vol.246
, pp. 482-486
-
-
Fuller, R.S.1
Brake, A.J.2
Thorner, J.3
-
31
-
-
12644253798
-
Defective prohormone processing and altered pancreatic islet morphology in mice lacking active SPC2
-
Furuta M, Yano H, Zhou A, Rouille Y, Holst JJ, Carroll R, Ravazzola M, Orci L, Furuta H & Steiner DF 1997 Defective prohormone processing and altered pancreatic islet morphology in mice lacking active SPC2. PNAS 94 6646-6651.
-
(1997)
PNAS
, vol.94
, pp. 6646-6651
-
-
Furuta, M.1
Yano, H.2
Zhou, A.3
Rouille, Y.4
Holst, J.J.5
Carroll, R.6
Ravazzola, M.7
Orci, L.8
Furuta, H.9
Steiner, D.F.10
-
32
-
-
0039825737
-
Isolation and structure of melancyte-stimulating hormone from porcine pituitary gland
-
Geschwind II, Li CH & Barnafi L 1956 Isolation and structure of melancyte-stimulating hormone from porcine pituitary gland. Journal of the American Chemical Society 78 4494-4495.
-
(1956)
Journal of the American Chemical Society
, vol.78
, pp. 4494-4495
-
-
Geschwind, I.I.1
Li, C.H.2
Barnafi, L.3
-
33
-
-
0018182334
-
Peptides in the brain: The new endocrinology of the neuron
-
Guillemin R 1978 Peptides in the brain: the new endocrinology of the neuron. Science 202 390-402.
-
(1978)
Science
, vol.202
, pp. 390-402
-
-
Guillemin, R.1
-
34
-
-
0000902061
-
Amino-acid sequence of the alphamelanocyte-stimulating hormone
-
Harris JI & Lerner AB 1957 Amino-acid sequence of the alphamelanocyte-stimulating hormone. Nature 179 1346-1347.
-
(1957)
Nature
, vol.179
, pp. 1346-1347
-
-
Harris, J.I.1
Lerner, A.B.2
-
35
-
-
0041011299
-
Amino-acid sequence of a melanophorestimulating peptide
-
Harris JI & Roos P 1956 Amino-acid sequence of a melanophorestimulating peptide. Nature 178 90.
-
(1956)
Nature
, vol.178
, pp. 90
-
-
Harris, J.I.1
Roos, P.2
-
36
-
-
0013583237
-
Discovery of pro-opiomelanocortin-a cellular polyprotein
-
Herbert E 1981 Discovery of pro-opiomelanocortin-a cellular polyprotein. Trends in Biochemical Sciences 6 184-188.
-
(1981)
Trends in Biochemical Sciences
, vol.6
, pp. 184-188
-
-
Herbert, E.1
-
38
-
-
81155144367
-
Chemistry and function of polypeptide hormones
-
Hofmann K 1962 Chemistry and function of polypeptide hormones. Annual Review of Biochemistry 31 213-246. (doi:10.1146/annurev. bi.31.070162.001241).
-
(1962)
Annual Review of Biochemistry
, vol.31
, pp. 213-246
-
-
Hofmann, K.1
-
39
-
-
0027365466
-
Immunocytochemical localization of the neuropeptidesynthesizing enzyme PC1 in AtT-20 cells
-
Hornby PJ, Rosenthal SD, Mathis JP, Vindrola O & Lindberg I 1993 Immunocytochemical localization of the neuropeptidesynthesizing enzyme PC1 in AtT-20 cells. Neuroendocrinology 58 555-563.
-
(1993)
Neuroendocrinology
, vol.58
, pp. 555-563
-
-
Hornby, P.J.1
Rosenthal, S.D.2
Mathis, J.P.3
Vindrola, O.4
Lindberg, I.5
-
40
-
-
0016701344
-
Identification of two related pentapeptides from the brain with potent opiate agonist activity
-
Hughes J, Smith TW, Kosterlitz HW, Fothergill LA, Morgan BA & Morris HR 1975 Identification of two related pentapeptides from the brain with potent opiate agonist activity. Nature 258 577-580.
-
(1975)
Nature
, vol.258
, pp. 577-580
-
-
Hughes, J.1
Smith, T.W.2
Kosterlitz, H.W.3
Fothergill, L.A.4
Morgan, B.A.5
Morris, H.R.6
-
41
-
-
77949429060
-
Genetic variation at the proprotein convertase subtilisin/kexin type 5 gene modulates high-density lipoprotein cholesterol levels
-
Iatan I, Dastani Z, Do R, Weissglas-Volkov D, Ruel I, Lee JC, Huertas-Vazquez A, Taskinen MR, Prat A, Seidah NG, et al. 2009 Genetic variation at the proprotein convertase subtilisin/kexin type 5 gene modulates high-density lipoprotein cholesterol levels. Circulation: Cardiovascular Genetics 2 467-475. (doi:10.1161/ CIRCGENETICS.109.877811).
-
(2009)
Circulation: Cardiovascular Genetics
, vol.2
, pp. 467-475
-
-
Iatan, I.1
Dastani, Z.2
Do, R.3
Weissglas-Volkov, D.4
Ruel, I.5
Lee, J.C.6
Huertas-Vazquez, A.7
Taskinen, M.R.8
Prat, A.9
Seidah, N.G.10
-
42
-
-
0030949271
-
Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene
-
Jackson RS, Creemers JW, Ohagi S, Raffin-Sanson ML, Sanders L, Montague CT, Hutton JC & O'Rahilly S 1997 Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene. Nature Genetics 16 303-306. (doi:10.1038/ng0797-303)
-
(1997)
Nature Genetics
, vol.16
, pp. 303-306
-
-
Jackson, R.S.1
Creemers, J.W.2
Ohagi, S.3
Raffin-Sanson, M.L.4
Sanders, L.5
Montague, C.T.6
Hutton, J.C.7
O'Rahilly, S.8
-
43
-
-
0017345956
-
Mouse pituitary tumor mRNA directed cell-free synthesis of polypeptides that are crossreactive with adrenocorticotropic hormone antiserum
-
Jones RE, Pulkrabek P & Grunberger D 1977 Mouse pituitary tumor mRNA directed cell-free synthesis of polypeptides that are crossreactive with adrenocorticotropic hormone antiserum. Biochemical and Biophysical Research Communications 74 1490-1495.
-
(1977)
Biochemical and Biophysical Research Communications
, vol.74
, pp. 1490-1495
-
-
Jones, R.E.1
Pulkrabek, P.2
Grunberger, D.3
-
44
-
-
0036083664
-
Proprotein convertases in tumor progression and malignancy-novel targets in cancer therapy
-
Khatib AM, Siegfried G, Chretien M, Metrakos P & Seidah NG 2002 Proprotein convertases in tumor progression and malignancy-novel targets in cancer therapy. American Journal of Pathology 160 1921-1935.
-
(2002)
American Journal of Pathology
, vol.160
, pp. 1921-1935
-
-
Khatib, A.M.1
Siegfried, G.2
Chretien, M.3
Metrakos, P.4
Seidah, N.G.5
-
45
-
-
0014786571
-
The biological and immunological properties of pork and beef insulin, proinsulin, and connecting peptides
-
Kitabchi AE 1970 The biological and immunological properties of pork and beef insulin, proinsulin, and connecting peptides. Journal of Clinical Investigation 49 979-987. (doi:10.1172/JCI106317)
-
(1970)
Journal of Clinical Investigation
, vol.49
, pp. 979-987
-
-
Kitabchi, A.E.1
-
46
-
-
0017113432
-
Beta-Lipotropin as a prohormone for the morphinomimetic peptides endorphins and enkephalins
-
Lazarus LH, Ling N & Guillemin R 1976 beta-Lipotropin as a prohormone for the morphinomimetic peptides endorphins and enkephalins. PNAS 73 2156-2159.
-
(1976)
PNAS
, vol.73
, pp. 2156-2159
-
-
Lazarus, L.H.1
Ling, N.2
Guillemin, R.3
-
48
-
-
36949089288
-
Amino-acid sequence of alpha-corticotropin
-
Li CH, Geschwind II, Cole RD, Raacke ID, Harris JI & Dixon JS 1955 Amino-acid sequence of alpha-corticotropin. Nature 176 687-689.
-
(1955)
Nature
, vol.176
, pp. 687-689
-
-
Li, C.H.1
Geschwind, I.I.2
Cole, R.D.3
Raacke, I.D.4
Harris, J.I.5
Dixon, J.S.6
-
49
-
-
0013846483
-
Isolation and amino-acid sequence of beta-LPH from sheep pituitary glands
-
Li CH, Barnafi L, Chretien M & Chung D 1965 Isolation and amino-acid sequence of beta-LPH from sheep pituitary glands. Nature 208 1093-1094.
-
(1965)
Nature
, vol.208
, pp. 1093-1094
-
-
Li, C.H.1
Barnafi, L.2
Chretien, M.3
Chung, D.4
-
51
-
-
0016751822
-
Molecular weights of adrenocorticotropic hormone in extracts of anterior and intermediate-posterior lobes of mouse pituitary
-
Mains RE & Eipper BA 1975 Molecular weights of adrenocorticotropic hormone in extracts of anterior and intermediate-posterior lobes of mouse pituitary. PNAS 72 3565-3569.
-
(1975)
PNAS
, vol.72
, pp. 3565-3569
-
-
Mains, R.E.1
Eipper, B.A.2
-
52
-
-
0017165051
-
Biosynthesis of adrenocorticotropic hormone in mouse pituitary tumor cells
-
Mains RE & Eipper BA 1976 Biosynthesis of adrenocorticotropic hormone in mouse pituitary tumor cells. Journal of Biological Chemistry 251 4115-4120.
-
(1976)
Journal of Biological Chemistry
, vol.251
, pp. 4115-4120
-
-
Mains, R.E.1
Eipper, B.A.2
-
53
-
-
0000011578
-
Common precursor to corticotropins and endorphins
-
Mains RE, Eipper BA & Ling N 1977 Common precursor to corticotropins and endorphins. PNAS 74 3014-3018.
-
(1977)
PNAS
, vol.74
, pp. 3014-3018
-
-
Mains, R.E.1
Eipper, B.A.2
Ling, N.3
-
54
-
-
0008261096
-
A new method for sequencing DNA
-
Maxam AM & Gilbert W 1977 A new method for sequencing DNA. PNAS 74 560-564.
-
(1977)
PNAS
, vol.74
, pp. 560-564
-
-
Maxam, A.M.1
Gilbert, W.2
-
55
-
-
80053432726
-
Novel loss-of-function PCSK9 variant is associated with low plasma LDL cholesterol in a French-Canadian family and with impaired processing and secretion in cell culture
-
Mayne J, Dewpura T, Raymond A, Bernier L, Cousins M, Ooi TC, Davignon J, Seidah NG, Mbikay M & Chretien M 2011 Novel loss-of-function PCSK9 variant is associated with low plasma LDL cholesterol in a French-Canadian family and with impaired processing and secretion in cell culture. Clinical Chemistry 57 1415-1423. (doi:10.1373/clinchem.2011.165191)
-
(2011)
Clinical Chemistry
, vol.57
, pp. 1415-1423
-
-
Mayne, J.1
Dewpura, T.2
Raymond, A.3
Bernier, L.4
Cousins, M.5
Ooi, T.C.6
Davignon, J.7
Seidah, N.G.8
Mbikay, M.9
Chretien, M.10
-
56
-
-
0030909584
-
Comparative analysis of expression of the proprotein convertases furin, PACE4, PC1 and PC2 in human lung tumours
-
Mbikay M, Sirois F, Yao J, Seidah NG & Chretien M 1997 Comparative analysis of expression of the proprotein convertases furin, PACE4, PC1 and PC2 in human lung tumours. British Journal of Cancer 75 1509-1514.
-
(1997)
British Journal of Cancer
, vol.75
, pp. 1509-1514
-
-
Mbikay, M.1
Sirois, F.2
Yao, J.3
Seidah, N.G.4
Chretien, M.5
-
57
-
-
0035878968
-
Neuroendocrine secretory protein 7B2: Structure, expression and functions
-
Mbikay M, Seidah NG & Chretien M 2001 Neuroendocrine secretory protein 7B2: structure, expression and functions. Biochemical Journal 357 329-342.
-
(2001)
Biochemical Journal
, vol.357
, pp. 329-342
-
-
Mbikay, M.1
Seidah, N.G.2
Chretien, M.3
-
58
-
-
77649274263
-
PCSK9-deficient mice exhibit impaired glucose tolerance and pancreatic islet abnormalities
-
Mbikay M, Sirois F, Mayne J, Wang GS, Chen A, Dewpura T, Prat A, Seidah NG, Chretien M & Scott FW 2010 PCSK9-deficient mice exhibit impaired glucose tolerance and pancreatic islet abnormalities. FEBS Letters 584 701-706. (doi:10.1016/j.febslet.2009.12.018)
-
(2010)
FEBS Letters
, vol.584
, pp. 701-706
-
-
Mbikay, M.1
Sirois, F.2
Mayne, J.3
Wang, G.S.4
Chen, A.5
Dewpura, T.6
Prat, A.7
Seidah, N.G.8
Chretien, M.9
Scott, F.W.10
-
59
-
-
84887018396
-
Proprotein convertases subtilisin/kexin type 9, an enzyme turned escort protein: Hepatic and extra hepatic functions
-
Mbikay M, Mayne J & Chretien M 2013 Proprotein convertases subtilisin/kexin type 9, an enzyme turned escort protein: hepatic and extra hepatic functions. Journal of Diabetes 5 391-405.
-
(2013)
Journal of Diabetes
, vol.5
, pp. 391-405
-
-
Mbikay, M.1
Mayne, J.2
Chretien, M.3
-
60
-
-
0041302361
-
Obliteration of alpha-melanocyte-stimulating hormone derived from POMC in pituitary and brains of PC2-deficient mice
-
Miller R, Aaron W, Toneff T, Vishnuvardhan D, Beinfeld MC & Hook VY 2003 Obliteration of alpha-melanocyte-stimulating hormone derived from POMC in pituitary and brains of PC2-deficient mice. Journal of Neurochemistry 86 556-563.
-
(2003)
Journal of Neurochemistry
, vol.86
, pp. 556-563
-
-
Miller, R.1
Aaron, W.2
Toneff, T.3
Vishnuvardhan, D.4
Beinfeld, M.C.5
Hook, V.Y.6
-
61
-
-
0021183904
-
A novel protease from yeast with specificity towards paired basic residues
-
Mizuno K & Matsuo H 1984 A novel protease from yeast with specificity towards paired basic residues. Nature 309 558-560.
-
(1984)
Nature
, vol.309
, pp. 558-560
-
-
Mizuno, K.1
Matsuo, H.2
-
62
-
-
0028107656
-
Intracellular trafficking and activation of the furin proprotein convertase: Localization to the TGN and recycling from the cell surface
-
Molloy SS, Thomas L, VanSlyke JK, Stenberg PE & Thomas G 1994 Intracellular trafficking and activation of the furin proprotein convertase: localization to the TGN and recycling from the cell surface. EMBO Journal 13 18-33.
-
(1994)
EMBO Journal
, vol.13
, pp. 18-33
-
-
Molloy, S.S.1
Thomas, L.2
VanSlyke, J.K.3
Stenberg, P.E.4
Thomas, G.5
-
63
-
-
0017047851
-
A large product of cell-free translation of messenger RNA coding for corticotropin
-
Nakanishi S, Taii S, Hirata Y, Matsukura S & Imura H 1976 A large product of cell-free translation of messenger RNA coding for corticotropin. PNAS 73 4319-4323.
-
(1976)
PNAS
, vol.73
, pp. 4319-4323
-
-
Nakanishi, S.1
Taii, S.2
Hirata, Y.3
Matsukura, S.4
Imura, H.5
-
64
-
-
0017643585
-
Cell-free translation product containing corticotropin and beta-endorphin encoded by messenger RNA from anterior lobe and intermediate lobe of bovine pituitary
-
Nakanishi S, Inoue A, Taii S & Numa S 1977 Cell-free translation product containing corticotropin and beta-endorphin encoded by messenger RNA from anterior lobe and intermediate lobe of bovine pituitary. FEBS Letters 84 105-109.
-
(1977)
FEBS Letters
, vol.84
, pp. 105-109
-
-
Nakanishi, S.1
Inoue, A.2
Taii, S.3
Numa, S.4
-
65
-
-
0018346407
-
Nucleotide sequence of cloned cDNA for bovine corticotropin-beta-lipotropin precursor
-
Nakanishi S, Inoue A, Kita T, Nakamura M, Chang AC, Cohen SN & Numa S 1979 Nucleotide sequence of cloned cDNA for bovine corticotropin-beta-lipotropin precursor. Nature 278 423-427.
-
(1979)
Nature
, vol.278
, pp. 423-427
-
-
Nakanishi, S.1
Inoue, A.2
Kita, T.3
Nakamura, M.4
Chang, A.C.5
Cohen, S.N.6
Numa, S.7
-
66
-
-
84930456827
-
Contribution of common non-synonymous variants in PCSK1 to body mass index variation and risk of obesity: A systematic review and meta-analysis with evidence from up to 331 175 individuals
-
Nead KT, Li A, Wehner MR, Neupane B, Gustafsson S, Butterworth A, Engert JC, Davis AD, Hegele RA, Miller R, et al. 2015 Contribution of common non-synonymous variants in PCSK1 to body mass index variation and risk of obesity: a systematic review and meta-analysis with evidence from up to 331 175 individuals. Human Molecular Genetics 24 3582-3594. (doi:10.1093/hmg/ddv097)
-
(2015)
Human Molecular Genetics
, vol.24
, pp. 3582-3594
-
-
Nead, K.T.1
Li, A.2
Wehner, M.R.3
Neupane, B.4
Gustafsson, S.5
Butterworth, A.6
Engert, J.C.7
Davis, A.D.8
Hegele, R.A.9
Miller, R.10
-
67
-
-
0001215657
-
ACTH-producing tumor of the pituitary gland
-
Nelson DH, Meakin JW, Dealy JB Jr, Matson DD, Emerson K Jr & Thorn GW 1958 ACTH-producing tumor of the pituitary gland. New England Journal of Medicine 259 161-164. (doi:10.1056/ NEJM195807242590403).
-
(1958)
New England Journal of Medicine
, vol.259
, pp. 161-164
-
-
Nelson, D.H.1
Meakin, J.W.2
Dealy, J.B.3
Matson, D.D.4
Emerson, K.5
Thorn, G.W.6
-
68
-
-
79551586854
-
Novel association to the proprotein convertase PCSK7 gene locus revealed by analysing soluble transferrin receptor (sTfR) levels
-
Oexle K, Ried JS, Hicks AA, Tanaka T, Hayward C, Bruegel M, Gogele M, Lichtner P, Muller-Myhsok B, Doring A, et al. 2011 Novel association to the proprotein convertase PCSK7 gene locus revealed by analysing soluble transferrin receptor (sTfR) levels. Human Molecular Genetics 20 1042-1047. (doi:10.1093/hmg/ddq538)
-
(2011)
Human Molecular Genetics
, vol.20
, pp. 1042-1047
-
-
Oexle, K.1
Ried, J.S.2
Hicks, A.A.3
Tanaka, T.4
Hayward, C.5
Bruegel, M.6
Gogele, M.7
Lichtner, P.8
Muller-Myhsok, B.9
Doring, A.10
-
70
-
-
84930021340
-
Emerging PCSK9 inhibitors for treating dyslipidaemia: Buttressing the gaps in coronary prevention
-
Page MM & Watts GF 2015 Emerging PCSK9 inhibitors for treating dyslipidaemia: buttressing the gaps in coronary prevention. Expert Opinion on Emerging Drugs 20 299-312. (doi:10.1517/14728214.2015. 1035709).
-
(2015)
Expert Opinion on Emerging Drugs
, vol.20
, pp. 299-312
-
-
Page, M.M.1
Watts, G.F.2
-
71
-
-
84878237040
-
Viral envelope glycoprotein processing by proprotein convertases
-
Pasquato A, Ramos da Palma J, Galan C, Seidah NG & Kunz S 2013 Viral envelope glycoprotein processing by proprotein convertases. Antiviral Research 99 49-60. (doi:10.1016/j.antiviral.2013.04.013)
-
(2013)
Antiviral Research
, vol.99
, pp. 49-60
-
-
Pasquato, A.1
Ramos da Palma, J.2
Galan, C.3
Seidah, N.G.4
Kunz, S.5
-
72
-
-
0017326743
-
Immunohistochemical localization of beta-lipotropic hormone in the pituitary gland
-
Pelletier G, Leclerc R, Labrie F, Cote J, Chretien M & Lis M 1977 Immunohistochemical localization of beta-lipotropic hormone in the pituitary gland. Endocrinology 100 770-776.
-
(1977)
Endocrinology
, vol.100
, pp. 770-776
-
-
Pelletier, G.1
Leclerc, R.2
Labrie, F.3
Cote, J.4
Chretien, M.5
Lis, M.6
-
73
-
-
0014868976
-
Specific demonstration of the human hypophyseal cells which produce adrenocorticotropic hormone
-
Phifer RF, Spicer SS & Orth DN 1970 Specific demonstration of the human hypophyseal cells which produce adrenocorticotropic hormone. Journal of Clinical Endocrinology and Metabolism 31 347-361. (doi:10.1210/jcem-31-4-347)
-
(1970)
Journal of Clinical Endocrinology and Metabolism
, vol.31
, pp. 347-361
-
-
Phifer, R.F.1
Spicer, S.S.2
Orth, D.N.3
-
74
-
-
0016291184
-
Specific demonstration of the human hypophyseal adrenocortico-melanotropic (ACTH-MSH) cell
-
Phifer RF, Orth DN & Spicer SS 1974 Specific demonstration of the human hypophyseal adrenocortico-melanotropic (ACTH-MSH) cell. Journal of Clinical Endocrinology and Metabolism 39 684-692. (doi:10.1210/jcem-39-4-684)
-
(1974)
Journal of Clinical Endocrinology and Metabolism
, vol.39
, pp. 684-692
-
-
Phifer, R.F.1
Orth, D.N.2
Spicer, S.S.3
-
75
-
-
84922657340
-
A nonsense loss-of-function mutation in PCSK1 contributes to dominantly inherited human obesity
-
Philippe J, Stijnen P, Meyre D, De Graeve F, Thuillier D, Delplanque J, Gyapay G, Sand O, Creemers JW, Froguel P et al. 2015 A nonsense loss-of-function mutation in PCSK1 contributes to dominantly inherited human obesity. International Journal of Obesity 39 295-302. (doi:10.1038/ijo.2014.96)
-
(2015)
International Journal of Obesity
, vol.39
, pp. 295-302
-
-
Philippe, J.1
Stijnen, P.2
Meyre, D.3
De Graeve, F.4
Thuillier, D.5
Delplanque, J.6
Gyapay, G.7
Sand, O.8
Creemers, J.W.9
Froguel, P.10
-
76
-
-
0019447259
-
Evidence for a signal sequence at the N terminus of the common precursor to adrenocorticothrophin and betalipotropin in mouse pituitary cells
-
Policastro P, Phillips M, Oates E, Herbert E, Roberts JL, Seidah N & Chretien M 1981 Evidence for a signal sequence at the N terminus of the common precursor to adrenocorticothrophin and betalipotropin in mouse pituitary cells. European Journal of Biochemistry 116 255-259.
-
(1981)
European Journal of Biochemistry
, vol.116
, pp. 255-259
-
-
Policastro, P.1
Phillips, M.2
Oates, E.3
Herbert, E.4
Roberts, J.L.5
Seidah, N.6
Chretien, M.7
-
77
-
-
0015524282
-
Revised amino-acid sequences for porcine and human adrenocorticotrophic hormone
-
Riniker B, Sieber P, Rittel W & Zuber H 1972 Revised amino-acid sequences for porcine and human adrenocorticotrophic hormone. Nature: New Biology 235 114-115.
-
(1972)
Nature: New Biology
, vol.235
, pp. 114-115
-
-
Riniker, B.1
Sieber, P.2
Rittel, W.3
Zuber, H.4
-
78
-
-
0017721394
-
Characterization of a common precursor to corticotropin and beta-lipotropin: Identification of betalipotropin peptides and their arrangement relative to corticotropin in the precursor synthesized in a cell-free system
-
Roberts JL & Herbert E 1977 Characterization of a common precursor to corticotropin and beta-lipotropin: identification of betalipotropin peptides and their arrangement relative to corticotropin in the precursor synthesized in a cell-free system. PNAS 74 5300-5304.
-
(1977)
PNAS
, vol.74
, pp. 5300-5304
-
-
Roberts, J.L.1
Herbert, E.2
-
79
-
-
0018184836
-
Steps involved in the processing of common precursor forms of adrenocorticotropin and endorphin in cultures of mouse pituitary cells
-
Roberts JL, Phillips M, Rosa PA & Herbert E 1978 Steps involved in the processing of common precursor forms of adrenocorticotropin and endorphin in cultures of mouse pituitary cells. Biochemistry 17 3609-3618.
-
(1978)
Biochemistry
, vol.17
, pp. 3609-3618
-
-
Roberts, J.L.1
Phillips, M.2
Rosa, P.A.3
Herbert, E.4
-
80
-
-
0006127553
-
Corticotropin and beta-endorphin: Construction and analysis of recombinant DNA complementary to mRNA for the common precursor
-
Roberts JL, Seeburg PH, Shine J, Herbert E, Baxter JD & Goodman HM 1979 Corticotropin and beta-endorphin: construction and analysis of recombinant DNA complementary to mRNA for the common precursor. PNAS 76 2153-2157.
-
(1979)
PNAS
, vol.76
, pp. 2153-2157
-
-
Roberts, J.L.1
Seeburg, P.H.2
Shine, J.3
Herbert, E.4
Baxter, J.D.5
Goodman, H.M.6
-
81
-
-
0022779175
-
Evolutionary conserved close linkage of the c-fes/fps proto-oncogene and genetic sequences encoding a receptor-like protein
-
Roebroek AJ, Schalken JA, Leunissen JA, Onnekink C, Bloemers HP & Van de Ven WJ 1986 Evolutionary conserved close linkage of the c-fes/fps proto-oncogene and genetic sequences encoding a receptor-like protein. EMBO Journal 5 2197-2202.
-
(1986)
EMBO Journal
, vol.5
, pp. 2197-2202
-
-
Roebroek, A.J.1
Schalken, J.A.2
Leunissen, J.A.3
Onnekink, C.4
Bloemers, H.P.5
Van de Ven, W.J.6
-
82
-
-
77949342702
-
The free amino groups of insulin
-
Sanger F 1945 The free amino groups of insulin. Biochemical Journal 39 507-515.
-
(1945)
Biochemical Journal
, vol.39
, pp. 507-515
-
-
Sanger, F.1
-
83
-
-
37049241552
-
Chemistry of insulin; determination of the structure of insulin opens the way to greater understanding of life processes
-
Sanger F 1959 Chemistry of insulin; determination of the structure of insulin opens the way to greater understanding of life processes. Science 129 1340-1344.
-
(1959)
Science
, vol.129
, pp. 1340-1344
-
-
Sanger, F.1
-
84
-
-
0023916658
-
Sequences, sequences, and sequences
-
Sanger F 1988 Sequences, sequences, and sequences. Annual Review of Biochemistry 57 1-28. (doi:10.1146/annurev.bi.57.070188.000245)
-
(1988)
Annual Review of Biochemistry
, vol.57
, pp. 1-28
-
-
Sanger, F.1
-
85
-
-
0017681196
-
DNA sequencing with chainterminating inhibitors
-
Sanger F, Nicklen S & Coulson AR 1977 DNA sequencing with chainterminating inhibitors. PNAS 74 5463-5467.
-
(1977)
PNAS
, vol.74
, pp. 5463-5467
-
-
Sanger, F.1
Nicklen, S.2
Coulson, A.R.3
-
86
-
-
0015420640
-
Corticotrophin-like intermediate lobe peptide--a new pituitary and tumour peptide
-
Scott AP, Bennett HP, Lowry PJ, McMartin C & Ratcliffe JG 1972 Corticotrophin-like intermediate lobe peptide--a new pituitary and tumour peptide. Journal of Endocrinology 55 xxxvi-xxxv.
-
(1972)
Journal of Endocrinology
, vol.55
, pp. xxxvi-xxxxv
-
-
Scott, A.P.1
Bennett, H.P.2
Lowry, P.J.3
McMartin, C.4
Ratcliffe, J.G.5
-
87
-
-
0016194254
-
Purification and characterization of porcine corticotrophin-like intermediate lobe peptide
-
Scott AP, Lowry PJ, Bennett HP, McMartin C & Ratcliffe JG 1974 Purification and characterization of porcine corticotrophin-like intermediate lobe peptide. Journal of Endocrinology 61 369-380. (doi:10.1677/joe.0.0610369)
-
(1974)
Journal of Endocrinology
, vol.61
, pp. 369-380
-
-
Scott, A.P.1
Lowry, P.J.2
Bennett, H.P.3
McMartin, C.4
Ratcliffe, J.G.5
-
88
-
-
80054752024
-
The proprotein convertases, 20 years later
-
Seidah NG 2011 The proprotein convertases, 20 years later. Methods in Molecular Biology 768 23-57. (doi:10.1007/978-1-61779-204-5_3)
-
(2011)
Methods in Molecular Biology
, vol.768
, pp. 23-57
-
-
Seidah, N.G.1
-
89
-
-
0026742108
-
Proprotein and prohormone convertases of the subtilisin family Recent developments and future perspectives
-
Seidah NG & Chretien M 1992 Proprotein and prohormone convertases of the subtilisin family Recent developments and future perspectives. Trends in Endocrinology and Metabolism 3 133-140.
-
(1992)
Trends in Endocrinology and Metabolism
, vol.3
, pp. 133-140
-
-
Seidah, N.G.1
Chretien, M.2
-
90
-
-
0033452452
-
Proprotein and prohormone convertases: A family of subtilases generating diverse bioactive polypeptides
-
Seidah NG & Chretien M 1999 Proprotein and prohormone convertases: a family of subtilases generating diverse bioactive polypeptides. Brain Research 848 45-62.
-
(1999)
Brain Research
, vol.848
, pp. 45-62
-
-
Seidah, N.G.1
Chretien, M.2
-
91
-
-
84860383419
-
The biology and therapeutic targeting of the proprotein convertases
-
Seidah NG & Prat A 2012 The biology and therapeutic targeting of the proprotein convertases. Nature Reviews: Drug Discovery 11 367-383.
-
(2012)
Nature Reviews: Drug Discovery
, vol.11
, pp. 367-383
-
-
Seidah, N.G.1
Prat, A.2
-
92
-
-
0025622849
-
cDNA sequence of two distinct pituitary proteins homologous to Kex2 and furin gene products: Tissue-specific mRNAs encoding candidates for pro-hormone processing proteinases
-
Seidah NG, Gaspar L, Mion P, Marcinkiewicz M, Mbikay M & Chretien M 1990 cDNA sequence of two distinct pituitary proteins homologous to Kex2 and furin gene products: tissue-specific mRNAs encoding candidates for pro-hormone processing proteinases. DNA and Cell Biology 9 789.
-
(1990)
DNA and Cell Biology
, vol.9
, pp. 789
-
-
Seidah, N.G.1
Gaspar, L.2
Mion, P.3
Marcinkiewicz, M.4
Mbikay, M.5
Chretien, M.6
-
93
-
-
0025214491
-
Identification of a human insulinoma cDNA encoding a novel mammalian protein structurally related to the yeast dibasic processing protease Kex2
-
Smeekens SP & Steiner DF 1990 Identification of a human insulinoma cDNA encoding a novel mammalian protein structurally related to the yeast dibasic processing protease Kex2. Journal of Biological Chemistry 265 2997-3000.
-
(1990)
Journal of Biological Chemistry
, vol.265
, pp. 2997-3000
-
-
Smeekens, S.P.1
Steiner, D.F.2
-
94
-
-
0026088633
-
Identification of a cDNA encoding a second putative prohormone convertase related to PC2 in AtT20 cells and islets of Langerhans
-
Smeekens SP, Avruch AS, LaMendola J, Chan SJ & Steiner DF 1991 Identification of a cDNA encoding a second putative prohormone convertase related to PC2 in AtT20 cells and islets of Langerhans. PNAS 88 340-344.
-
(1991)
PNAS
, vol.88
, pp. 340-344
-
-
Smeekens, S.P.1
Avruch, A.S.2
LaMendola, J.3
Chan, S.J.4
Steiner, D.F.5
-
95
-
-
84941368607
-
Proprotein convertases in atherogenesis
-
Stawowy P 2015 Proprotein convertases in atherogenesis. Current Opinion in Lipidology 26 338-344. (doi:10.1097/MOL.0000000000000182)
-
(2015)
Current Opinion in Lipidology
, vol.26
, pp. 338-344
-
-
Stawowy, P.1
-
96
-
-
80054739248
-
The molecular biology of furin-like proprotein convertases in vascular remodelling
-
Stawowy P & Kappert K 2011 The molecular biology of furin-like proprotein convertases in vascular remodelling. Methods in Molecular Biology 768 191-206. (doi:10.1007/978-1-61779-204-5_9)
-
(2011)
Methods in Molecular Biology
, vol.768
, pp. 191-206
-
-
Stawowy, P.1
Kappert, K.2
-
98
-
-
84938258457
-
PCSK9 inhibitors and neurocognitive adverse events: Exploring the FDA directive and a proposal for N-of-1 trials
-
Swiger KJ & Martin SS 2015 PCSK9 inhibitors and neurocognitive adverse events: exploring the FDA directive and a proposal for N-of-1 trials. Drug Safety 38 519-526. (doi:10.1007/s40264-015-0296-6)
-
(2015)
Drug Safety
, vol.38
, pp. 519-526
-
-
Swiger, K.J.1
Martin, S.S.2
-
99
-
-
0016410236
-
Methods for the assessment of peptide precursors. Studies insulin biosynthesis
-
Tager HS, Rubenstein AH & Steiner DF 1975 Methods for the assessment of peptide precursors. Studies insulin biosynthesis. Methods in Enzymology 37 326-345.
-
(1975)
Methods in Enzymology
, vol.37
, pp. 326-345
-
-
Tager, H.S.1
Rubenstein, A.H.2
Steiner, D.F.3
-
100
-
-
0031951875
-
Localization of prohormone convertases 1/3 and 2 in the human pituitary gland and pituitary adenomas: Analysis by immunohistochemistry, immunoelectron microscopy, and laser scanning microscopy
-
Takumi I, Steiner DF, Sanno N, Teramoto A & Osamura RY 1998 Localization of prohormone convertases 1/3 and 2 in the human pituitary gland and pituitary adenomas: analysis by immunohistochemistry, immunoelectron microscopy, and laser scanning microscopy. Modern Pathology 11 232-238.
-
(1998)
Modern Pathology
, vol.11
, pp. 232-238
-
-
Takumi, I.1
Steiner, D.F.2
Sanno, N.3
Teramoto, A.4
Osamura, R.Y.5
-
101
-
-
79955776778
-
Differential gene expression profiles of POMC-related enzymes, transcription factors and receptors between non-pituitary and pituitary ACTH-secreting tumors
-
Tani Y, Sugiyama T, Izumiyama H, Yoshimoto T, Yamada S & Hirata Y 2011 Differential gene expression profiles of POMC-related enzymes, transcription factors and receptors between non-pituitary and pituitary ACTH-secreting tumors. Endocrine Journal 58 297-303.
-
(2011)
Endocrine Journal
, vol.58
, pp. 297-303
-
-
Tani, Y.1
Sugiyama, T.2
Izumiyama, H.3
Yoshimoto, T.4
Yamada, S.5
Hirata, Y.6
-
102
-
-
38349061561
-
Differential gene expression in ACTH-secreting and non-functioning pituitary tumors
-
Tateno T, Izumiyama H, Doi M, Yoshimoto T, Shichiri M, Inoshita N, Oyama K, Yamada S & Hirata Y 2007 Differential gene expression in ACTH-secreting and non-functioning pituitary tumors. European Journal of Endocrinology 157 717-724. (doi:10.1530/EJE-07-0428)
-
(2007)
European Journal of Endocrinology
, vol.157
, pp. 717-724
-
-
Tateno, T.1
Izumiyama, H.2
Doi, M.3
Yoshimoto, T.4
Shichiri, M.5
Inoshita, N.6
Oyama, K.7
Yamada, S.8
Hirata, Y.9
-
103
-
-
0036791359
-
Furin at the cutting edge: From protein traffic to embryogenesis and disease
-
Thomas G 2002 Furin at the cutting edge: from protein traffic to embryogenesis and disease. Nature Reviews: Molecular Cell Biology 3 753-766. (doi:10.1038/nrm934)
-
(2002)
Nature Reviews: Molecular Cell Biology
, vol.3
, pp. 753-766
-
-
Thomas, G.1
-
104
-
-
0024281623
-
Yeast KEX2 endopeptidase correctly cleaves a neuroendocrine prohormone in mammalian cells
-
Thomas G, Thorne BA, Thomas L, Allen RG, Hruby DE, Fuller R & Thorner J 1988 Yeast KEX2 endopeptidase correctly cleaves a neuroendocrine prohormone in mammalian cells. Science 241 226-230.
-
(1988)
Science
, vol.241
, pp. 226-230
-
-
Thomas, G.1
Thorne, B.A.2
Thomas, L.3
Allen, R.G.4
Hruby, D.E.5
Fuller, R.6
Thorner, J.7
-
105
-
-
82955232396
-
Proprotein convertases in human atherosclerotic plaques: The overexpression of FURIN and its substrate cytokines BAFF and APRIL
-
Turpeinen H, Raitoharju E, Oksanen A, Oksala N, Levula M, Lyytikainen LP, Jarvinen O, Creemers JW, Kahonen M, Laaksonen R, et al. 2011 Proprotein convertases in human atherosclerotic plaques: the overexpression of FURIN and its substrate cytokines BAFF and APRIL. Atherosclerosis 219 799-806. (doi:10.1016/j. atherosclerosis.2011.08.011).
-
(2011)
Atherosclerosis
, vol.219
, pp. 799-806
-
-
Turpeinen, H.1
Raitoharju, E.2
Oksanen, A.3
Oksala, N.4
Levula, M.5
Lyytikainen, L.P.6
Jarvinen, O.7
Creemers, J.W.8
Kahonen, M.9
Laaksonen, R.10
-
106
-
-
0026772528
-
Biosynthesis of the prohormone convertase mPC1 in AtT-20 cells
-
Vindrola O & Lindberg I 1992 Biosynthesis of the prohormone convertase mPC1 in AtT-20 cells. Molecular Endocrinology 6 1088-1094. (doi:10.1210/mend.6.7.1508222)
-
(1992)
Molecular Endocrinology
, vol.6
, pp. 1088-1094
-
-
Vindrola, O.1
Lindberg, I.2
-
107
-
-
84908229451
-
PCSK9 is a critical regulator of the innate immune response and septic shock outcome
-
258ra143
-
Walley KR, Thain KR, Russell JA, Reilly MP, Meyer NJ, Ferguson JF, Christie JD, Nakada TA, Fjell CD, Thair SA, et al. 2014 PCSK9 is a critical regulator of the innate immune response and septic shock outcome. Science Translational Medicine 6 258ra143. (doi:10.1126/ scitranslmed.3008782).
-
(2014)
Science Translational Medicine
, vol.6
-
-
Walley, K.R.1
Thain, K.R.2
Russell, J.A.3
Reilly, M.P.4
Meyer, N.J.5
Ferguson, J.F.6
Christie, J.D.7
Nakada, T.A.8
Fjell, C.D.9
Thair, S.A.10
-
108
-
-
80054727597
-
Quantitative peptidomics of mice lacking peptide-processing enzymes
-
Wardman J & Fricker LD 2011 Quantitative peptidomics of mice lacking peptide-processing enzymes. Methods in Molecular Biology 768 307-323. (doi:10.1007/978-1-61779-204-5_17)
-
(2011)
Methods in Molecular Biology
, vol.768
, pp. 307-323
-
-
Wardman, J.1
Fricker, L.D.2
-
109
-
-
84941421913
-
The apoB-to-PCSK9 ratio: A new index for metabolic risk in humans
-
Wassef H, Bissonnette S, Saint-Pierre N, Lamantia V, Cyr Y, Chretien M & Faraj M 2015 The apoB-to-PCSK9 ratio: a new index for metabolic risk in humans. Journal of Clinical Lipidology 9 664-675. (doi:10.1016/j.jacl.2015.06.012)
-
(2015)
Journal of Clinical Lipidology
, vol.9
, pp. 664-675
-
-
Wassef, H.1
Bissonnette, S.2
Saint-Pierre, N.3
Lamantia, V.4
Cyr, Y.5
Chretien, M.6
Faraj, M.7
-
110
-
-
0019956615
-
The carboxy terminus of the precursor to vasopressin and neurophysin: Immunocytochemistry in rat brain
-
Watson SJ, Seidah NG & Chretien M 1982 The carboxy terminus of the precursor to vasopressin and neurophysin: immunocytochemistry in rat brain. Science 217 853-855.
-
(1982)
Science
, vol.217
, pp. 853-855
-
-
Watson, S.J.1
Seidah, N.G.2
Chretien, M.3
-
111
-
-
0018135025
-
Concomitant storage of ACTHand endorphin-like immunoreactivity in the secretory granules of anterior pituitary corticotrophs
-
Weber E, Voigt KH & Martin R 1978 Concomitant storage of ACTHand endorphin-like immunoreactivity in the secretory granules of anterior pituitary corticotrophs. Brain Research 157 385-390.
-
(1978)
Brain Research
, vol.157
, pp. 385-390
-
-
Weber, E.1
Voigt, K.H.2
Martin, R.3
-
112
-
-
84896694715
-
PCSK9 gene mutations and low-density lipoprotein cholesterol
-
Wu NQ & Li JJ 2014 PCSK9 gene mutations and low-density lipoprotein cholesterol. Clinica Chimica Acta 431 148-153. (doi:10.1016/ j.cca.2014.01.043).
-
(2014)
Clinica Chimica Acta
, vol.431
, pp. 148-153
-
-
Wu, N.Q.1
Li, J.J.2
-
113
-
-
84937758043
-
Update of clinical trials of anti-PCSK9 antibodies
-
Wu NQ, Li S & Li JJ 2015 Update of clinical trials of anti-PCSK9 antibodies. Cardiovascular Drugs and Therapy 29 159-169. (doi:10.1007/s10557-015-6582-9)
-
(2015)
Cardiovascular Drugs and Therapy
, vol.29
, pp. 159-169
-
-
Wu, N.Q.1
Li, S.2
Li, J.J.3
-
114
-
-
0015595436
-
Characteristics of "big ACTH" in human plasma and pituitary extracts
-
Yalow RS & Berson SA 1973 Characteristics of "big ACTH" in human plasma and pituitary extracts. Journal of Clinical Endocrinology and Metabolism 36 415-423. (doi:10.1210/jcem-36-3-415)
-
(1973)
Journal of Clinical Endocrinology and Metabolism
, vol.36
, pp. 415-423
-
-
Yalow, R.S.1
Berson, S.A.2
-
115
-
-
84855186825
-
Association of type 2 diabetes susceptibility genes (TCF7L2, SLC30A8, PCSK1 and PCSK2) and proinsulin conversion in a Chinese population
-
Zheng X, Ren W, Zhang S, Liu J, Li S, Li J, Yang P, He J, Su S & Li P 2012 Association of type 2 diabetes susceptibility genes (TCF7L2, SLC30A8, PCSK1 and PCSK2) and proinsulin conversion in a Chinese population. Molecular Biology Reports 39 17-23. (doi:10.1007/s11033-011-0705-6)
-
(2012)
Molecular Biology Reports
, vol.39
, pp. 17-23
-
-
Zheng, X.1
Ren, W.2
Zhang, S.3
Liu, J.4
Li, S.5
Li, J.6
Yang, P.7
He, J.8
Su, S.9
Li, P.10
-
116
-
-
0036679173
-
Disruption of PC1/3 expression in mice causes dwarfism and multiple neuroendocrine peptide processing defects
-
Zhu X, Zhou A, Dey A, Norrbom C, Carroll R, Zhang C, Laurent V, Lindberg I, Ugleholdt R, Holst JJ, et al. 2002 Disruption of PC1/3 expression in mice causes dwarfism and multiple neuroendocrine peptide processing defects. PNAS 99 10293-10298. (doi:10.1073/ pnas.162352599)
-
(2002)
PNAS
, vol.99
, pp. 10293-10298
-
-
Zhu, X.1
Zhou, A.2
Dey, A.3
Norrbom, C.4
Carroll, R.5
Zhang, C.6
Laurent, V.7
Lindberg, I.8
Ugleholdt, R.9
Holst, J.J.10
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