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Volumn 56, Issue 4, 2016, Pages T49-T62

From the prohormone theory to pro-opiomelanocortin and to proprotein convertases (PCSK1 to PCSK9)

Author keywords

Endoproteolysis; POMC; Prohormone; Proprotein convertases

Indexed keywords

ALPHA INTERMEDIN; BETA ENDORPHIN; BETA INTERMEDIN; BETA LIPOTROPIN; COMPLEMENTARY DNA; CORTICOTROPIN; GAMMA LIPOTROPIN; HORMONE PRECURSOR; LIPOTROPIN; PROOPIOMELANOCORTIN; PROPROTEIN CONVERTASE 1; PROPROTEIN CONVERTASE 2; PROPROTEIN CONVERTASE 3; PROPROTEIN CONVERTASE 4; PROPROTEIN CONVERTASE 5; PROPROTEIN CONVERTASE 6; PROPROTEIN CONVERTASE 7; PROPROTEIN CONVERTASE 8; PROPROTEIN CONVERTASE 9; SERINE PROTEINASE; UNCLASSIFIED DRUG; ENZYME PRECURSOR; ISOENZYME; PEPTIDE HORMONE; PROTEIN PRECURSOR;

EID: 84973316256     PISSN: 09525041     EISSN: 14796813     Source Type: Journal    
DOI: 10.1530/JME-15-0261     Document Type: Review
Times cited : (44)

References (116)
  • 1
    • 84855393059 scopus 로고    scopus 로고
    • Proprotein convertases in health and disease
    • Artenstein AW & Opal SM 2011 Proprotein convertases in health and disease. New England Journal of Medicine 365 2507-2518. (doi:10.1056/NEJMra1106700)
    • (2011) New England Journal of Medicine , vol.365 , pp. 2507-2518
    • Artenstein, A.W.1    Opal, S.M.2
  • 2
    • 0025762119 scopus 로고
    • PC1 and PC2 are proprotein convertases capable of cleaving proopiomelanocortin at distinct pairs of basic residues
    • Benjannet S, Rondeau N, Day R, Chretien M & Seidah NG 1991 PC1 and PC2 are proprotein convertases capable of cleaving proopiomelanocortin at distinct pairs of basic residues. PNAS 88 3564-3568.
    • (1991) PNAS , vol.88 , pp. 3564-3568
    • Benjannet, S.1    Rondeau, N.2    Day, R.3    Chretien, M.4    Seidah, N.G.5
  • 4
    • 78651150366 scopus 로고
    • Isolation and properties of a new, biologically active peptide from sheep pituitary glands
    • Birk Y & Li CH 1964 Isolation and properties of a new, biologically active peptide from sheep pituitary glands. Journal of Biological Chemistry 239 1048-1052.
    • (1964) Journal of Biological Chemistry , vol.239 , pp. 1048-1052
    • Birk, Y.1    Li, C.H.2
  • 5
    • 0026398206 scopus 로고
    • Prohormone-converting enzymes: Regulation and evaluation of function using antisense RNA
    • Bloomquist BT, Eipper BA & Mains RE 1991 Prohormone-converting enzymes: regulation and evaluation of function using antisense RNA. Molecular Endocrinology 5 2014-2024.
    • (1991) Molecular Endocrinology , vol.5 , pp. 2014-2024
    • Bloomquist, B.T.1    Eipper, B.A.2    Mains, R.E.3
  • 6
    • 0014411801 scopus 로고
    • Porcine proinsulin: Characterization and amino acid sequence
    • Chance RE, Ellis RM & Bromer WW 1968 Porcine proinsulin: characterization and amino acid sequence. Science 161 165-167.
    • (1968) Science , vol.161 , pp. 165-167
    • Chance, R.E.1    Ellis, R.M.2    Bromer, W.W.3
  • 7
    • 84866928259 scopus 로고    scopus 로고
    • My road to Damascus: How I converted to the prohormone theory and the proprotein convertases
    • Chretien M 2012 My road to Damascus: how I converted to the prohormone theory and the proprotein convertases. Biochemistry and Cell Biology 90 750-768. (doi:10.1139/o2012-031)
    • (2012) Biochemistry and Cell Biology , vol.90 , pp. 750-768
    • Chretien, M.1
  • 8
    • 0014107316 scopus 로고
    • Isolation, purification, and characterization of gamma-lipotropic hormone from sheep pituitary glands
    • Chretien M & Li CH 1967 Isolation, purification, and characterization of gamma-lipotropic hormone from sheep pituitary glands. Canadian Journal of Biochemistry 45 1163-1174.
    • (1967) Canadian Journal of Biochemistry , vol.45 , pp. 1163-1174
    • Chretien, M.1    Li, C.H.2
  • 13
    • 0024805307 scopus 로고
    • Functional diversity of bioactive peptides in the nervous system itself: "how the brain may understand"
    • Chretien M, Sikstrom RA, Lazure C, Mbikay M & Seidah NG 1989 Functional diversity of bioactive peptides in the nervous system itself: "how the brain may understand". Bioscience Reports 9 693-700.
    • (1989) Bioscience Reports , vol.9 , pp. 693-700
    • Chretien, M.1    Sikstrom, R.A.2    Lazure, C.3    Mbikay, M.4    Seidah, N.G.5
  • 16
    • 0017579124 scopus 로고
    • In vitro biosynthesis of beta-endorphin in pituitary glands
    • Crine P, Benjannet S, Seidah NG, Lis M & Chretien M 1977 In vitro biosynthesis of beta-endorphin in pituitary glands. PNAS 74 1403-1406.
    • (1977) PNAS , vol.74 , pp. 1403-1406
    • Crine, P.1    Benjannet, S.2    Seidah, N.G.3    Lis, M.4    Chretien, M.5
  • 17
    • 0018189453 scopus 로고
    • Biosynthesis of beta-endorphin from betalipotropin and a larger molecular weight precursor in rat pars intermedia
    • Crine P, Gianoulakis C, Seidah NG, Gossard F, Pezalla PD, Lis M & Chretien M 1978 Biosynthesis of beta-endorphin from betalipotropin and a larger molecular weight precursor in rat pars intermedia. PNAS 75 4719-4723.
    • (1978) PNAS , vol.75 , pp. 4719-4723
    • Crine, P.1    Gianoulakis, C.2    Seidah, N.G.3    Gossard, F.4    Pezalla, P.D.5    Lis, M.6    Chretien, M.7
  • 18
    • 0000156413 scopus 로고
    • The basophil adenomas of the pituitary body and their clinical manifestations
    • Cushing H 1932 The basophil adenomas of the pituitary body and their clinical manifestations. Bulletin of the Johns Hopkins Hospital 30 137-195.
    • (1932) Bulletin of the Johns Hopkins Hospital , vol.30 , pp. 137-195
    • Cushing, H.1
  • 19
    • 0023408598 scopus 로고
    • Proteolytic conversion of proinsulin into insulin. Identification of a Ca2+-dependent acidic endopeptidase in isolated insulin-secretory granules
    • Davidson HW, Peshavaria M & Hutton JC 1987 Proteolytic conversion of proinsulin into insulin. Identification of a Ca2+-dependent acidic endopeptidase in isolated insulin-secretory granules. Biochemical Journal 246 279-286.
    • (1987) Biochemical Journal , vol.246 , pp. 279-286
    • Davidson, H.W.1    Peshavaria, M.2    Hutton, J.C.3
  • 20
    • 0026609102 scopus 로고
    • Distribution and regulation of the prohormone convertases PC1 and PC2 in the rat pituitary
    • Day R, Schafer MK, Watson SJ, Chretien M & Seidah NG 1992 Distribution and regulation of the prohormone convertases PC1 and PC2 in the rat pituitary. Molecular Endocrinology 6 485-497.
    • (1992) Molecular Endocrinology , vol.6 , pp. 485-497
    • Day, R.1    Schafer, M.K.2    Watson, S.J.3    Chretien, M.4    Seidah, N.G.5
  • 22
    • 0021196999 scopus 로고
    • Polyprotein gene expression: Generation of diversity of neuroendocrine peptides
    • Douglass J, Civelli O & Herbert E 1984 Polyprotein gene expression: generation of diversity of neuroendocrine peptides. Annual Review of Biochemistry 53 665-715. (doi:10.1146/annurev.bi.53.070184.003313)
    • (1984) Annual Review of Biochemistry , vol.53 , pp. 665-715
    • Douglass, J.1    Civelli, O.2    Herbert, E.3
  • 23
    • 0019180771 scopus 로고
    • Most of the coding region of rat ACTH beta-LPH precursor gene lacks intervening sequences
    • Drouin J & Goodman HM 1980 Most of the coding region of rat ACTH beta-LPH precursor gene lacks intervening sequences. Nature 288 610-613.
    • (1980) Nature , vol.288 , pp. 610-613
    • Drouin, J.1    Goodman, H.M.2
  • 24
    • 0001433809 scopus 로고
    • Method for determination of the amino acid sequence in peptides
    • Edman P 1950 Method for determination of the amino acid sequence in peptides. Acta Chemica Scandinavica 4 283-293.
    • (1950) Acta Chemica Scandinavica , vol.4 , pp. 283-293
    • Edman, P.1
  • 25
    • 0019268826 scopus 로고
    • Structure and biosynthesis of proadrenocorticotropin/ endorphin and related peptides
    • Eipper BA & Mains RE 1980 Structure and biosynthesis of proadrenocorticotropin/ endorphin and related peptides. Endocrine Reviews 1 1-27. (doi:10.1210/edrv-1-1-1)
    • (1980) Endocrine Reviews , vol.1 , pp. 1-27
    • Eipper, B.A.1    Mains, R.E.2
  • 26
    • 0017127902 scopus 로고
    • High molecular weight forms of adrenocorticotropic hormone are glycoproteins
    • Eipper BA, Mains RE & Guenzi D 1976 High molecular weight forms of adrenocorticotropic hormone are glycoproteins. Journal of Biological Chemistry 251 4121-4126.
    • (1976) Journal of Biological Chemistry , vol.251 , pp. 4121-4126
    • Eipper, B.A.1    Mains, R.E.2    Guenzi, D.3
  • 27
    • 0026514908 scopus 로고
    • The biosynthesis of neuropeptides: Peptide alpha-amidation
    • Eipper BA, Stoffers DA & Mains RE 1992 The biosynthesis of neuropeptides: peptide alpha-amidation. Annual Review of Neuroscience 15 57-85. (doi:10.1146/annurev.ne.15.030192.000421).
    • (1992) Annual Review of Neuroscience , vol.15 , pp. 57-85
    • Eipper, B.A.1    Stoffers, D.A.2    Mains, R.E.3
  • 29
    • 0000611868 scopus 로고
    • Yeast prohormone processing enzyme (KEX2 gene product) is a Ca2+-dependent serine protease
    • Fuller RS, Brake A & Thorner J 1989a Yeast prohormone processing enzyme (KEX2 gene product) is a Ca2+-dependent serine protease. PNAS 86 1434-1438.
    • (1989) PNAS , vol.86 , pp. 1434-1438
    • Fuller, R.S.1    Brake, A.2    Thorner, J.3
  • 30
    • 0024425494 scopus 로고
    • Intracellular targeting and structural conservation of a prohormone-processing endoprotease
    • Fuller RS, Brake AJ & Thorner J 1989b Intracellular targeting and structural conservation of a prohormone-processing endoprotease. Science 246 482-486.
    • (1989) Science , vol.246 , pp. 482-486
    • Fuller, R.S.1    Brake, A.J.2    Thorner, J.3
  • 32
    • 0039825737 scopus 로고
    • Isolation and structure of melancyte-stimulating hormone from porcine pituitary gland
    • Geschwind II, Li CH & Barnafi L 1956 Isolation and structure of melancyte-stimulating hormone from porcine pituitary gland. Journal of the American Chemical Society 78 4494-4495.
    • (1956) Journal of the American Chemical Society , vol.78 , pp. 4494-4495
    • Geschwind, I.I.1    Li, C.H.2    Barnafi, L.3
  • 33
    • 0018182334 scopus 로고
    • Peptides in the brain: The new endocrinology of the neuron
    • Guillemin R 1978 Peptides in the brain: the new endocrinology of the neuron. Science 202 390-402.
    • (1978) Science , vol.202 , pp. 390-402
    • Guillemin, R.1
  • 34
    • 0000902061 scopus 로고
    • Amino-acid sequence of the alphamelanocyte-stimulating hormone
    • Harris JI & Lerner AB 1957 Amino-acid sequence of the alphamelanocyte-stimulating hormone. Nature 179 1346-1347.
    • (1957) Nature , vol.179 , pp. 1346-1347
    • Harris, J.I.1    Lerner, A.B.2
  • 35
    • 0041011299 scopus 로고
    • Amino-acid sequence of a melanophorestimulating peptide
    • Harris JI & Roos P 1956 Amino-acid sequence of a melanophorestimulating peptide. Nature 178 90.
    • (1956) Nature , vol.178 , pp. 90
    • Harris, J.I.1    Roos, P.2
  • 36
    • 0013583237 scopus 로고
    • Discovery of pro-opiomelanocortin-a cellular polyprotein
    • Herbert E 1981 Discovery of pro-opiomelanocortin-a cellular polyprotein. Trends in Biochemical Sciences 6 184-188.
    • (1981) Trends in Biochemical Sciences , vol.6 , pp. 184-188
    • Herbert, E.1
  • 38
    • 81155144367 scopus 로고
    • Chemistry and function of polypeptide hormones
    • Hofmann K 1962 Chemistry and function of polypeptide hormones. Annual Review of Biochemistry 31 213-246. (doi:10.1146/annurev. bi.31.070162.001241).
    • (1962) Annual Review of Biochemistry , vol.31 , pp. 213-246
    • Hofmann, K.1
  • 39
  • 40
    • 0016701344 scopus 로고
    • Identification of two related pentapeptides from the brain with potent opiate agonist activity
    • Hughes J, Smith TW, Kosterlitz HW, Fothergill LA, Morgan BA & Morris HR 1975 Identification of two related pentapeptides from the brain with potent opiate agonist activity. Nature 258 577-580.
    • (1975) Nature , vol.258 , pp. 577-580
    • Hughes, J.1    Smith, T.W.2    Kosterlitz, H.W.3    Fothergill, L.A.4    Morgan, B.A.5    Morris, H.R.6
  • 43
    • 0017345956 scopus 로고
    • Mouse pituitary tumor mRNA directed cell-free synthesis of polypeptides that are crossreactive with adrenocorticotropic hormone antiserum
    • Jones RE, Pulkrabek P & Grunberger D 1977 Mouse pituitary tumor mRNA directed cell-free synthesis of polypeptides that are crossreactive with adrenocorticotropic hormone antiserum. Biochemical and Biophysical Research Communications 74 1490-1495.
    • (1977) Biochemical and Biophysical Research Communications , vol.74 , pp. 1490-1495
    • Jones, R.E.1    Pulkrabek, P.2    Grunberger, D.3
  • 45
    • 0014786571 scopus 로고
    • The biological and immunological properties of pork and beef insulin, proinsulin, and connecting peptides
    • Kitabchi AE 1970 The biological and immunological properties of pork and beef insulin, proinsulin, and connecting peptides. Journal of Clinical Investigation 49 979-987. (doi:10.1172/JCI106317)
    • (1970) Journal of Clinical Investigation , vol.49 , pp. 979-987
    • Kitabchi, A.E.1
  • 46
    • 0017113432 scopus 로고
    • Beta-Lipotropin as a prohormone for the morphinomimetic peptides endorphins and enkephalins
    • Lazarus LH, Ling N & Guillemin R 1976 beta-Lipotropin as a prohormone for the morphinomimetic peptides endorphins and enkephalins. PNAS 73 2156-2159.
    • (1976) PNAS , vol.73 , pp. 2156-2159
    • Lazarus, L.H.1    Ling, N.2    Guillemin, R.3
  • 49
    • 0013846483 scopus 로고
    • Isolation and amino-acid sequence of beta-LPH from sheep pituitary glands
    • Li CH, Barnafi L, Chretien M & Chung D 1965 Isolation and amino-acid sequence of beta-LPH from sheep pituitary glands. Nature 208 1093-1094.
    • (1965) Nature , vol.208 , pp. 1093-1094
    • Li, C.H.1    Barnafi, L.2    Chretien, M.3    Chung, D.4
  • 51
    • 0016751822 scopus 로고
    • Molecular weights of adrenocorticotropic hormone in extracts of anterior and intermediate-posterior lobes of mouse pituitary
    • Mains RE & Eipper BA 1975 Molecular weights of adrenocorticotropic hormone in extracts of anterior and intermediate-posterior lobes of mouse pituitary. PNAS 72 3565-3569.
    • (1975) PNAS , vol.72 , pp. 3565-3569
    • Mains, R.E.1    Eipper, B.A.2
  • 52
    • 0017165051 scopus 로고
    • Biosynthesis of adrenocorticotropic hormone in mouse pituitary tumor cells
    • Mains RE & Eipper BA 1976 Biosynthesis of adrenocorticotropic hormone in mouse pituitary tumor cells. Journal of Biological Chemistry 251 4115-4120.
    • (1976) Journal of Biological Chemistry , vol.251 , pp. 4115-4120
    • Mains, R.E.1    Eipper, B.A.2
  • 53
    • 0000011578 scopus 로고
    • Common precursor to corticotropins and endorphins
    • Mains RE, Eipper BA & Ling N 1977 Common precursor to corticotropins and endorphins. PNAS 74 3014-3018.
    • (1977) PNAS , vol.74 , pp. 3014-3018
    • Mains, R.E.1    Eipper, B.A.2    Ling, N.3
  • 54
    • 0008261096 scopus 로고
    • A new method for sequencing DNA
    • Maxam AM & Gilbert W 1977 A new method for sequencing DNA. PNAS 74 560-564.
    • (1977) PNAS , vol.74 , pp. 560-564
    • Maxam, A.M.1    Gilbert, W.2
  • 55
    • 80053432726 scopus 로고    scopus 로고
    • Novel loss-of-function PCSK9 variant is associated with low plasma LDL cholesterol in a French-Canadian family and with impaired processing and secretion in cell culture
    • Mayne J, Dewpura T, Raymond A, Bernier L, Cousins M, Ooi TC, Davignon J, Seidah NG, Mbikay M & Chretien M 2011 Novel loss-of-function PCSK9 variant is associated with low plasma LDL cholesterol in a French-Canadian family and with impaired processing and secretion in cell culture. Clinical Chemistry 57 1415-1423. (doi:10.1373/clinchem.2011.165191)
    • (2011) Clinical Chemistry , vol.57 , pp. 1415-1423
    • Mayne, J.1    Dewpura, T.2    Raymond, A.3    Bernier, L.4    Cousins, M.5    Ooi, T.C.6    Davignon, J.7    Seidah, N.G.8    Mbikay, M.9    Chretien, M.10
  • 56
    • 0030909584 scopus 로고    scopus 로고
    • Comparative analysis of expression of the proprotein convertases furin, PACE4, PC1 and PC2 in human lung tumours
    • Mbikay M, Sirois F, Yao J, Seidah NG & Chretien M 1997 Comparative analysis of expression of the proprotein convertases furin, PACE4, PC1 and PC2 in human lung tumours. British Journal of Cancer 75 1509-1514.
    • (1997) British Journal of Cancer , vol.75 , pp. 1509-1514
    • Mbikay, M.1    Sirois, F.2    Yao, J.3    Seidah, N.G.4    Chretien, M.5
  • 57
    • 0035878968 scopus 로고    scopus 로고
    • Neuroendocrine secretory protein 7B2: Structure, expression and functions
    • Mbikay M, Seidah NG & Chretien M 2001 Neuroendocrine secretory protein 7B2: structure, expression and functions. Biochemical Journal 357 329-342.
    • (2001) Biochemical Journal , vol.357 , pp. 329-342
    • Mbikay, M.1    Seidah, N.G.2    Chretien, M.3
  • 59
    • 84887018396 scopus 로고    scopus 로고
    • Proprotein convertases subtilisin/kexin type 9, an enzyme turned escort protein: Hepatic and extra hepatic functions
    • Mbikay M, Mayne J & Chretien M 2013 Proprotein convertases subtilisin/kexin type 9, an enzyme turned escort protein: hepatic and extra hepatic functions. Journal of Diabetes 5 391-405.
    • (2013) Journal of Diabetes , vol.5 , pp. 391-405
    • Mbikay, M.1    Mayne, J.2    Chretien, M.3
  • 60
    • 0041302361 scopus 로고    scopus 로고
    • Obliteration of alpha-melanocyte-stimulating hormone derived from POMC in pituitary and brains of PC2-deficient mice
    • Miller R, Aaron W, Toneff T, Vishnuvardhan D, Beinfeld MC & Hook VY 2003 Obliteration of alpha-melanocyte-stimulating hormone derived from POMC in pituitary and brains of PC2-deficient mice. Journal of Neurochemistry 86 556-563.
    • (2003) Journal of Neurochemistry , vol.86 , pp. 556-563
    • Miller, R.1    Aaron, W.2    Toneff, T.3    Vishnuvardhan, D.4    Beinfeld, M.C.5    Hook, V.Y.6
  • 61
    • 0021183904 scopus 로고
    • A novel protease from yeast with specificity towards paired basic residues
    • Mizuno K & Matsuo H 1984 A novel protease from yeast with specificity towards paired basic residues. Nature 309 558-560.
    • (1984) Nature , vol.309 , pp. 558-560
    • Mizuno, K.1    Matsuo, H.2
  • 62
    • 0028107656 scopus 로고
    • Intracellular trafficking and activation of the furin proprotein convertase: Localization to the TGN and recycling from the cell surface
    • Molloy SS, Thomas L, VanSlyke JK, Stenberg PE & Thomas G 1994 Intracellular trafficking and activation of the furin proprotein convertase: localization to the TGN and recycling from the cell surface. EMBO Journal 13 18-33.
    • (1994) EMBO Journal , vol.13 , pp. 18-33
    • Molloy, S.S.1    Thomas, L.2    VanSlyke, J.K.3    Stenberg, P.E.4    Thomas, G.5
  • 63
    • 0017047851 scopus 로고
    • A large product of cell-free translation of messenger RNA coding for corticotropin
    • Nakanishi S, Taii S, Hirata Y, Matsukura S & Imura H 1976 A large product of cell-free translation of messenger RNA coding for corticotropin. PNAS 73 4319-4323.
    • (1976) PNAS , vol.73 , pp. 4319-4323
    • Nakanishi, S.1    Taii, S.2    Hirata, Y.3    Matsukura, S.4    Imura, H.5
  • 64
    • 0017643585 scopus 로고
    • Cell-free translation product containing corticotropin and beta-endorphin encoded by messenger RNA from anterior lobe and intermediate lobe of bovine pituitary
    • Nakanishi S, Inoue A, Taii S & Numa S 1977 Cell-free translation product containing corticotropin and beta-endorphin encoded by messenger RNA from anterior lobe and intermediate lobe of bovine pituitary. FEBS Letters 84 105-109.
    • (1977) FEBS Letters , vol.84 , pp. 105-109
    • Nakanishi, S.1    Inoue, A.2    Taii, S.3    Numa, S.4
  • 65
    • 0018346407 scopus 로고
    • Nucleotide sequence of cloned cDNA for bovine corticotropin-beta-lipotropin precursor
    • Nakanishi S, Inoue A, Kita T, Nakamura M, Chang AC, Cohen SN & Numa S 1979 Nucleotide sequence of cloned cDNA for bovine corticotropin-beta-lipotropin precursor. Nature 278 423-427.
    • (1979) Nature , vol.278 , pp. 423-427
    • Nakanishi, S.1    Inoue, A.2    Kita, T.3    Nakamura, M.4    Chang, A.C.5    Cohen, S.N.6    Numa, S.7
  • 66
    • 84930456827 scopus 로고    scopus 로고
    • Contribution of common non-synonymous variants in PCSK1 to body mass index variation and risk of obesity: A systematic review and meta-analysis with evidence from up to 331 175 individuals
    • Nead KT, Li A, Wehner MR, Neupane B, Gustafsson S, Butterworth A, Engert JC, Davis AD, Hegele RA, Miller R, et al. 2015 Contribution of common non-synonymous variants in PCSK1 to body mass index variation and risk of obesity: a systematic review and meta-analysis with evidence from up to 331 175 individuals. Human Molecular Genetics 24 3582-3594. (doi:10.1093/hmg/ddv097)
    • (2015) Human Molecular Genetics , vol.24 , pp. 3582-3594
    • Nead, K.T.1    Li, A.2    Wehner, M.R.3    Neupane, B.4    Gustafsson, S.5    Butterworth, A.6    Engert, J.C.7    Davis, A.D.8    Hegele, R.A.9    Miller, R.10
  • 69
  • 70
    • 84930021340 scopus 로고    scopus 로고
    • Emerging PCSK9 inhibitors for treating dyslipidaemia: Buttressing the gaps in coronary prevention
    • Page MM & Watts GF 2015 Emerging PCSK9 inhibitors for treating dyslipidaemia: buttressing the gaps in coronary prevention. Expert Opinion on Emerging Drugs 20 299-312. (doi:10.1517/14728214.2015. 1035709).
    • (2015) Expert Opinion on Emerging Drugs , vol.20 , pp. 299-312
    • Page, M.M.1    Watts, G.F.2
  • 72
    • 0017326743 scopus 로고
    • Immunohistochemical localization of beta-lipotropic hormone in the pituitary gland
    • Pelletier G, Leclerc R, Labrie F, Cote J, Chretien M & Lis M 1977 Immunohistochemical localization of beta-lipotropic hormone in the pituitary gland. Endocrinology 100 770-776.
    • (1977) Endocrinology , vol.100 , pp. 770-776
    • Pelletier, G.1    Leclerc, R.2    Labrie, F.3    Cote, J.4    Chretien, M.5    Lis, M.6
  • 73
    • 0014868976 scopus 로고
    • Specific demonstration of the human hypophyseal cells which produce adrenocorticotropic hormone
    • Phifer RF, Spicer SS & Orth DN 1970 Specific demonstration of the human hypophyseal cells which produce adrenocorticotropic hormone. Journal of Clinical Endocrinology and Metabolism 31 347-361. (doi:10.1210/jcem-31-4-347)
    • (1970) Journal of Clinical Endocrinology and Metabolism , vol.31 , pp. 347-361
    • Phifer, R.F.1    Spicer, S.S.2    Orth, D.N.3
  • 74
    • 0016291184 scopus 로고
    • Specific demonstration of the human hypophyseal adrenocortico-melanotropic (ACTH-MSH) cell
    • Phifer RF, Orth DN & Spicer SS 1974 Specific demonstration of the human hypophyseal adrenocortico-melanotropic (ACTH-MSH) cell. Journal of Clinical Endocrinology and Metabolism 39 684-692. (doi:10.1210/jcem-39-4-684)
    • (1974) Journal of Clinical Endocrinology and Metabolism , vol.39 , pp. 684-692
    • Phifer, R.F.1    Orth, D.N.2    Spicer, S.S.3
  • 76
    • 0019447259 scopus 로고
    • Evidence for a signal sequence at the N terminus of the common precursor to adrenocorticothrophin and betalipotropin in mouse pituitary cells
    • Policastro P, Phillips M, Oates E, Herbert E, Roberts JL, Seidah N & Chretien M 1981 Evidence for a signal sequence at the N terminus of the common precursor to adrenocorticothrophin and betalipotropin in mouse pituitary cells. European Journal of Biochemistry 116 255-259.
    • (1981) European Journal of Biochemistry , vol.116 , pp. 255-259
    • Policastro, P.1    Phillips, M.2    Oates, E.3    Herbert, E.4    Roberts, J.L.5    Seidah, N.6    Chretien, M.7
  • 77
    • 0015524282 scopus 로고
    • Revised amino-acid sequences for porcine and human adrenocorticotrophic hormone
    • Riniker B, Sieber P, Rittel W & Zuber H 1972 Revised amino-acid sequences for porcine and human adrenocorticotrophic hormone. Nature: New Biology 235 114-115.
    • (1972) Nature: New Biology , vol.235 , pp. 114-115
    • Riniker, B.1    Sieber, P.2    Rittel, W.3    Zuber, H.4
  • 78
    • 0017721394 scopus 로고
    • Characterization of a common precursor to corticotropin and beta-lipotropin: Identification of betalipotropin peptides and their arrangement relative to corticotropin in the precursor synthesized in a cell-free system
    • Roberts JL & Herbert E 1977 Characterization of a common precursor to corticotropin and beta-lipotropin: identification of betalipotropin peptides and their arrangement relative to corticotropin in the precursor synthesized in a cell-free system. PNAS 74 5300-5304.
    • (1977) PNAS , vol.74 , pp. 5300-5304
    • Roberts, J.L.1    Herbert, E.2
  • 79
    • 0018184836 scopus 로고
    • Steps involved in the processing of common precursor forms of adrenocorticotropin and endorphin in cultures of mouse pituitary cells
    • Roberts JL, Phillips M, Rosa PA & Herbert E 1978 Steps involved in the processing of common precursor forms of adrenocorticotropin and endorphin in cultures of mouse pituitary cells. Biochemistry 17 3609-3618.
    • (1978) Biochemistry , vol.17 , pp. 3609-3618
    • Roberts, J.L.1    Phillips, M.2    Rosa, P.A.3    Herbert, E.4
  • 80
    • 0006127553 scopus 로고
    • Corticotropin and beta-endorphin: Construction and analysis of recombinant DNA complementary to mRNA for the common precursor
    • Roberts JL, Seeburg PH, Shine J, Herbert E, Baxter JD & Goodman HM 1979 Corticotropin and beta-endorphin: construction and analysis of recombinant DNA complementary to mRNA for the common precursor. PNAS 76 2153-2157.
    • (1979) PNAS , vol.76 , pp. 2153-2157
    • Roberts, J.L.1    Seeburg, P.H.2    Shine, J.3    Herbert, E.4    Baxter, J.D.5    Goodman, H.M.6
  • 81
    • 0022779175 scopus 로고
    • Evolutionary conserved close linkage of the c-fes/fps proto-oncogene and genetic sequences encoding a receptor-like protein
    • Roebroek AJ, Schalken JA, Leunissen JA, Onnekink C, Bloemers HP & Van de Ven WJ 1986 Evolutionary conserved close linkage of the c-fes/fps proto-oncogene and genetic sequences encoding a receptor-like protein. EMBO Journal 5 2197-2202.
    • (1986) EMBO Journal , vol.5 , pp. 2197-2202
    • Roebroek, A.J.1    Schalken, J.A.2    Leunissen, J.A.3    Onnekink, C.4    Bloemers, H.P.5    Van de Ven, W.J.6
  • 82
    • 77949342702 scopus 로고
    • The free amino groups of insulin
    • Sanger F 1945 The free amino groups of insulin. Biochemical Journal 39 507-515.
    • (1945) Biochemical Journal , vol.39 , pp. 507-515
    • Sanger, F.1
  • 83
    • 37049241552 scopus 로고
    • Chemistry of insulin; determination of the structure of insulin opens the way to greater understanding of life processes
    • Sanger F 1959 Chemistry of insulin; determination of the structure of insulin opens the way to greater understanding of life processes. Science 129 1340-1344.
    • (1959) Science , vol.129 , pp. 1340-1344
    • Sanger, F.1
  • 84
    • 0023916658 scopus 로고
    • Sequences, sequences, and sequences
    • Sanger F 1988 Sequences, sequences, and sequences. Annual Review of Biochemistry 57 1-28. (doi:10.1146/annurev.bi.57.070188.000245)
    • (1988) Annual Review of Biochemistry , vol.57 , pp. 1-28
    • Sanger, F.1
  • 85
    • 0017681196 scopus 로고
    • DNA sequencing with chainterminating inhibitors
    • Sanger F, Nicklen S & Coulson AR 1977 DNA sequencing with chainterminating inhibitors. PNAS 74 5463-5467.
    • (1977) PNAS , vol.74 , pp. 5463-5467
    • Sanger, F.1    Nicklen, S.2    Coulson, A.R.3
  • 87
    • 0016194254 scopus 로고
    • Purification and characterization of porcine corticotrophin-like intermediate lobe peptide
    • Scott AP, Lowry PJ, Bennett HP, McMartin C & Ratcliffe JG 1974 Purification and characterization of porcine corticotrophin-like intermediate lobe peptide. Journal of Endocrinology 61 369-380. (doi:10.1677/joe.0.0610369)
    • (1974) Journal of Endocrinology , vol.61 , pp. 369-380
    • Scott, A.P.1    Lowry, P.J.2    Bennett, H.P.3    McMartin, C.4    Ratcliffe, J.G.5
  • 88
    • 80054752024 scopus 로고    scopus 로고
    • The proprotein convertases, 20 years later
    • Seidah NG 2011 The proprotein convertases, 20 years later. Methods in Molecular Biology 768 23-57. (doi:10.1007/978-1-61779-204-5_3)
    • (2011) Methods in Molecular Biology , vol.768 , pp. 23-57
    • Seidah, N.G.1
  • 89
    • 0026742108 scopus 로고
    • Proprotein and prohormone convertases of the subtilisin family Recent developments and future perspectives
    • Seidah NG & Chretien M 1992 Proprotein and prohormone convertases of the subtilisin family Recent developments and future perspectives. Trends in Endocrinology and Metabolism 3 133-140.
    • (1992) Trends in Endocrinology and Metabolism , vol.3 , pp. 133-140
    • Seidah, N.G.1    Chretien, M.2
  • 90
    • 0033452452 scopus 로고    scopus 로고
    • Proprotein and prohormone convertases: A family of subtilases generating diverse bioactive polypeptides
    • Seidah NG & Chretien M 1999 Proprotein and prohormone convertases: a family of subtilases generating diverse bioactive polypeptides. Brain Research 848 45-62.
    • (1999) Brain Research , vol.848 , pp. 45-62
    • Seidah, N.G.1    Chretien, M.2
  • 91
    • 84860383419 scopus 로고    scopus 로고
    • The biology and therapeutic targeting of the proprotein convertases
    • Seidah NG & Prat A 2012 The biology and therapeutic targeting of the proprotein convertases. Nature Reviews: Drug Discovery 11 367-383.
    • (2012) Nature Reviews: Drug Discovery , vol.11 , pp. 367-383
    • Seidah, N.G.1    Prat, A.2
  • 92
    • 0025622849 scopus 로고
    • cDNA sequence of two distinct pituitary proteins homologous to Kex2 and furin gene products: Tissue-specific mRNAs encoding candidates for pro-hormone processing proteinases
    • Seidah NG, Gaspar L, Mion P, Marcinkiewicz M, Mbikay M & Chretien M 1990 cDNA sequence of two distinct pituitary proteins homologous to Kex2 and furin gene products: tissue-specific mRNAs encoding candidates for pro-hormone processing proteinases. DNA and Cell Biology 9 789.
    • (1990) DNA and Cell Biology , vol.9 , pp. 789
    • Seidah, N.G.1    Gaspar, L.2    Mion, P.3    Marcinkiewicz, M.4    Mbikay, M.5    Chretien, M.6
  • 93
    • 0025214491 scopus 로고
    • Identification of a human insulinoma cDNA encoding a novel mammalian protein structurally related to the yeast dibasic processing protease Kex2
    • Smeekens SP & Steiner DF 1990 Identification of a human insulinoma cDNA encoding a novel mammalian protein structurally related to the yeast dibasic processing protease Kex2. Journal of Biological Chemistry 265 2997-3000.
    • (1990) Journal of Biological Chemistry , vol.265 , pp. 2997-3000
    • Smeekens, S.P.1    Steiner, D.F.2
  • 94
    • 0026088633 scopus 로고
    • Identification of a cDNA encoding a second putative prohormone convertase related to PC2 in AtT20 cells and islets of Langerhans
    • Smeekens SP, Avruch AS, LaMendola J, Chan SJ & Steiner DF 1991 Identification of a cDNA encoding a second putative prohormone convertase related to PC2 in AtT20 cells and islets of Langerhans. PNAS 88 340-344.
    • (1991) PNAS , vol.88 , pp. 340-344
    • Smeekens, S.P.1    Avruch, A.S.2    LaMendola, J.3    Chan, S.J.4    Steiner, D.F.5
  • 95
    • 84941368607 scopus 로고    scopus 로고
    • Proprotein convertases in atherogenesis
    • Stawowy P 2015 Proprotein convertases in atherogenesis. Current Opinion in Lipidology 26 338-344. (doi:10.1097/MOL.0000000000000182)
    • (2015) Current Opinion in Lipidology , vol.26 , pp. 338-344
    • Stawowy, P.1
  • 96
    • 80054739248 scopus 로고    scopus 로고
    • The molecular biology of furin-like proprotein convertases in vascular remodelling
    • Stawowy P & Kappert K 2011 The molecular biology of furin-like proprotein convertases in vascular remodelling. Methods in Molecular Biology 768 191-206. (doi:10.1007/978-1-61779-204-5_9)
    • (2011) Methods in Molecular Biology , vol.768 , pp. 191-206
    • Stawowy, P.1    Kappert, K.2
  • 98
    • 84938258457 scopus 로고    scopus 로고
    • PCSK9 inhibitors and neurocognitive adverse events: Exploring the FDA directive and a proposal for N-of-1 trials
    • Swiger KJ & Martin SS 2015 PCSK9 inhibitors and neurocognitive adverse events: exploring the FDA directive and a proposal for N-of-1 trials. Drug Safety 38 519-526. (doi:10.1007/s40264-015-0296-6)
    • (2015) Drug Safety , vol.38 , pp. 519-526
    • Swiger, K.J.1    Martin, S.S.2
  • 99
    • 0016410236 scopus 로고
    • Methods for the assessment of peptide precursors. Studies insulin biosynthesis
    • Tager HS, Rubenstein AH & Steiner DF 1975 Methods for the assessment of peptide precursors. Studies insulin biosynthesis. Methods in Enzymology 37 326-345.
    • (1975) Methods in Enzymology , vol.37 , pp. 326-345
    • Tager, H.S.1    Rubenstein, A.H.2    Steiner, D.F.3
  • 100
    • 0031951875 scopus 로고    scopus 로고
    • Localization of prohormone convertases 1/3 and 2 in the human pituitary gland and pituitary adenomas: Analysis by immunohistochemistry, immunoelectron microscopy, and laser scanning microscopy
    • Takumi I, Steiner DF, Sanno N, Teramoto A & Osamura RY 1998 Localization of prohormone convertases 1/3 and 2 in the human pituitary gland and pituitary adenomas: analysis by immunohistochemistry, immunoelectron microscopy, and laser scanning microscopy. Modern Pathology 11 232-238.
    • (1998) Modern Pathology , vol.11 , pp. 232-238
    • Takumi, I.1    Steiner, D.F.2    Sanno, N.3    Teramoto, A.4    Osamura, R.Y.5
  • 101
    • 79955776778 scopus 로고    scopus 로고
    • Differential gene expression profiles of POMC-related enzymes, transcription factors and receptors between non-pituitary and pituitary ACTH-secreting tumors
    • Tani Y, Sugiyama T, Izumiyama H, Yoshimoto T, Yamada S & Hirata Y 2011 Differential gene expression profiles of POMC-related enzymes, transcription factors and receptors between non-pituitary and pituitary ACTH-secreting tumors. Endocrine Journal 58 297-303.
    • (2011) Endocrine Journal , vol.58 , pp. 297-303
    • Tani, Y.1    Sugiyama, T.2    Izumiyama, H.3    Yoshimoto, T.4    Yamada, S.5    Hirata, Y.6
  • 103
    • 0036791359 scopus 로고    scopus 로고
    • Furin at the cutting edge: From protein traffic to embryogenesis and disease
    • Thomas G 2002 Furin at the cutting edge: from protein traffic to embryogenesis and disease. Nature Reviews: Molecular Cell Biology 3 753-766. (doi:10.1038/nrm934)
    • (2002) Nature Reviews: Molecular Cell Biology , vol.3 , pp. 753-766
    • Thomas, G.1
  • 104
  • 106
    • 0026772528 scopus 로고
    • Biosynthesis of the prohormone convertase mPC1 in AtT-20 cells
    • Vindrola O & Lindberg I 1992 Biosynthesis of the prohormone convertase mPC1 in AtT-20 cells. Molecular Endocrinology 6 1088-1094. (doi:10.1210/mend.6.7.1508222)
    • (1992) Molecular Endocrinology , vol.6 , pp. 1088-1094
    • Vindrola, O.1    Lindberg, I.2
  • 108
    • 80054727597 scopus 로고    scopus 로고
    • Quantitative peptidomics of mice lacking peptide-processing enzymes
    • Wardman J & Fricker LD 2011 Quantitative peptidomics of mice lacking peptide-processing enzymes. Methods in Molecular Biology 768 307-323. (doi:10.1007/978-1-61779-204-5_17)
    • (2011) Methods in Molecular Biology , vol.768 , pp. 307-323
    • Wardman, J.1    Fricker, L.D.2
  • 110
    • 0019956615 scopus 로고
    • The carboxy terminus of the precursor to vasopressin and neurophysin: Immunocytochemistry in rat brain
    • Watson SJ, Seidah NG & Chretien M 1982 The carboxy terminus of the precursor to vasopressin and neurophysin: immunocytochemistry in rat brain. Science 217 853-855.
    • (1982) Science , vol.217 , pp. 853-855
    • Watson, S.J.1    Seidah, N.G.2    Chretien, M.3
  • 111
    • 0018135025 scopus 로고
    • Concomitant storage of ACTHand endorphin-like immunoreactivity in the secretory granules of anterior pituitary corticotrophs
    • Weber E, Voigt KH & Martin R 1978 Concomitant storage of ACTHand endorphin-like immunoreactivity in the secretory granules of anterior pituitary corticotrophs. Brain Research 157 385-390.
    • (1978) Brain Research , vol.157 , pp. 385-390
    • Weber, E.1    Voigt, K.H.2    Martin, R.3
  • 112
    • 84896694715 scopus 로고    scopus 로고
    • PCSK9 gene mutations and low-density lipoprotein cholesterol
    • Wu NQ & Li JJ 2014 PCSK9 gene mutations and low-density lipoprotein cholesterol. Clinica Chimica Acta 431 148-153. (doi:10.1016/ j.cca.2014.01.043).
    • (2014) Clinica Chimica Acta , vol.431 , pp. 148-153
    • Wu, N.Q.1    Li, J.J.2
  • 113
    • 84937758043 scopus 로고    scopus 로고
    • Update of clinical trials of anti-PCSK9 antibodies
    • Wu NQ, Li S & Li JJ 2015 Update of clinical trials of anti-PCSK9 antibodies. Cardiovascular Drugs and Therapy 29 159-169. (doi:10.1007/s10557-015-6582-9)
    • (2015) Cardiovascular Drugs and Therapy , vol.29 , pp. 159-169
    • Wu, N.Q.1    Li, S.2    Li, J.J.3
  • 114
    • 0015595436 scopus 로고
    • Characteristics of "big ACTH" in human plasma and pituitary extracts
    • Yalow RS & Berson SA 1973 Characteristics of "big ACTH" in human plasma and pituitary extracts. Journal of Clinical Endocrinology and Metabolism 36 415-423. (doi:10.1210/jcem-36-3-415)
    • (1973) Journal of Clinical Endocrinology and Metabolism , vol.36 , pp. 415-423
    • Yalow, R.S.1    Berson, S.A.2
  • 115
    • 84855186825 scopus 로고    scopus 로고
    • Association of type 2 diabetes susceptibility genes (TCF7L2, SLC30A8, PCSK1 and PCSK2) and proinsulin conversion in a Chinese population
    • Zheng X, Ren W, Zhang S, Liu J, Li S, Li J, Yang P, He J, Su S & Li P 2012 Association of type 2 diabetes susceptibility genes (TCF7L2, SLC30A8, PCSK1 and PCSK2) and proinsulin conversion in a Chinese population. Molecular Biology Reports 39 17-23. (doi:10.1007/s11033-011-0705-6)
    • (2012) Molecular Biology Reports , vol.39 , pp. 17-23
    • Zheng, X.1    Ren, W.2    Zhang, S.3    Liu, J.4    Li, S.5    Li, J.6    Yang, P.7    He, J.8    Su, S.9    Li, P.10
  • 116
    • 0036679173 scopus 로고    scopus 로고
    • Disruption of PC1/3 expression in mice causes dwarfism and multiple neuroendocrine peptide processing defects
    • Zhu X, Zhou A, Dey A, Norrbom C, Carroll R, Zhang C, Laurent V, Lindberg I, Ugleholdt R, Holst JJ, et al. 2002 Disruption of PC1/3 expression in mice causes dwarfism and multiple neuroendocrine peptide processing defects. PNAS 99 10293-10298. (doi:10.1073/ pnas.162352599)
    • (2002) PNAS , vol.99 , pp. 10293-10298
    • Zhu, X.1    Zhou, A.2    Dey, A.3    Norrbom, C.4    Carroll, R.5    Zhang, C.6    Laurent, V.7    Lindberg, I.8    Ugleholdt, R.9    Holst, J.J.10


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