-
1
-
-
84860118506
-
The delicate balance between secreted protein folding and endoplasmic reticulum-Associated degradation in human physiology
-
Guerriero, C. J., & Brodsky, J. L. The delicate balance between secreted protein folding and endoplasmic reticulum-Associated degradation in human physiology. Physiol. Rev. 92, 537-576 (2012).
-
(2012)
Physiol. Rev
, vol.92
, pp. 537-576
-
-
Guerriero, C.J.1
Brodsky, J.L.2
-
2
-
-
84870763849
-
The mammalian endoplasmic reticulum-Associated degradation system
-
Olzmann, J. A., Kopito, R. R., & Christianson, J. C. The mammalian endoplasmic reticulum-Associated degradation system. Cold Spring Harb. Perspect. Biol. 5, a013185 (2013).
-
(2013)
Cold Spring Harb. Perspect. Biol
, vol.5
, pp. a013185
-
-
Olzmann, J.A.1
Kopito, R.R.2
Christianson, J.C.3
-
3
-
-
0029811218
-
Role of 26s proteasome and hrd genes in the degradation of 3-hydroxy-3-methylglutaryl-coa reductase, an integral endoplasmic reticulum membrane protein
-
Hampton, R. Y., Gardner, R. G., & Rine, J. Role of 26S proteasome and HRD genes in the degradation of 3-hydroxy-3-methylglutaryl-CoA reductase, an integral endoplasmic reticulum membrane protein. Mol. Biol. Cell. 7, 2029-2044 (1996).
-
(1996)
Mol. Biol. Cell
, vol.7
, pp. 2029-2044
-
-
Hampton, R.Y.1
Gardner, R.G.2
Rine, J.3
-
4
-
-
84255169603
-
Defining human erad networks through an integrative mapping strategy
-
Christianson, J. C., et al. Defining human ERAD networks through an integrative mapping strategy. Nat. Cell Biol. 14, 93-105 (2012).
-
(2012)
Nat. Cell Biol
, vol.14
, pp. 93-105
-
-
Christianson, J.C.1
-
5
-
-
33750359201
-
SEL1Lfeti the homologue of yeast Hrd3p, is involved in protein dislocation from the mammalian ER
-
Mueller, B., Lilley, B. N., & Ploegh, H. L. SEL1L, the homologue of yeast Hrd3p, is involved in protein dislocation from the mammalian ER. J. Cell Biol. 175, 261-270 (2006).
-
(2006)
J. Cell Biol
, vol.175
, pp. 261-270
-
-
Mueller, B.1
Lilley, B.N.2
Ploegh, H.L.3
-
6
-
-
0034597161
-
Endoplasmic reticulum degradation requires lumen to cytosol signaling transmembrane control of hrd1p by hrd3p
-
Gardner, R. G., et al. Endoplasmic reticulum degradation requires lumen to cytosol signaling. Transmembrane control of Hrd1p by Hrd3p. J. Cell Biol. 151, 69-82 (2000).
-
(2000)
J. Cell Biol
, vol.151
, pp. 69-82
-
-
Gardner, R.G.1
-
7
-
-
0033492290
-
Genetic interactions of hrd3p and der3p/hrd1p with sec61p suggest a retro-Translocation complex mediating protein transport for er degradation
-
Plemper, R. K., et al. Genetic interactions of Hrd3p and Der3p/Hrd1p with Sec61p suggest a retro-Translocation complex mediating protein transport for ER degradation. J. Cell Sci. 112, 4123-4134 (1999).
-
(1999)
J. Cell Sci
, vol.112
, pp. 4123-4134
-
-
Plemper, R.K.1
-
8
-
-
33746228127
-
Distinct ubiquitin-ligase complexes define convergent pathways for the degradation of er proteins
-
Carvalho, P., Goder, V., & Rapoport, T. A. Distinct ubiquitin-ligase complexes define convergent pathways for the degradation of ER proteins. Cell. 126, 361-373 (2006).
-
(2006)
Cell
, vol.126
, pp. 361-373
-
-
Carvalho, P.1
Goder, V.2
Rapoport, T.A.3
-
9
-
-
50449107542
-
Sel1l nucleates a protein complex required for dislocation of misfolded glycoproteins
-
Mueller, B., Klemm, E. J., Spooner, E., Claessen, J. H., & Ploegh, H. L. SEL1L nucleates a protein complex required for dislocation of misfolded glycoproteins. Proc. Natl Acad. Sci. USA. 105, 12325-12330 (2008).
-
(2008)
Proc. Natl Acad. Sci. USA
, vol.105
, pp. 12325-12330
-
-
Mueller, B.1
Klemm, E.J.2
Spooner, E.3
Claessen, J.H.4
Ploegh, H.L.5
-
10
-
-
84893517295
-
Sel1l is indispensable for mammalian endoplasmic reticulumassociated degradation, endoplasmic reticulum homeostasis, and survival
-
Sun, S., et al. Sel1L is indispensable for mammalian endoplasmic reticulumassociated degradation, endoplasmic reticulum homeostasis, and survival. Proc. Natl Acad. Sci. USA. 111, E582-E591 (2014).
-
(2014)
Proc. Natl Acad. Sci. USA
, vol.111
, pp. E582-E591
-
-
Sun, S.1
-
11
-
-
84913536702
-
The er-Associated degradation adaptor protein sel1l regulates lpl secretion and lipid metabolism
-
Sha, H., et al. The ER-Associated degradation adaptor protein Sel1L regulates LPL secretion and lipid metabolism. Cell Metab. 20, 458-470 (2014).
-
(2014)
Cell Metab
, vol.20
, pp. 458-470
-
-
Sha, H.1
-
12
-
-
0033782015
-
Dynamic interaction of bip and er stress transducers in the unfolded-protein response
-
Bertolotti, A., Zhang, Y., Hendershot, L. M., Harding, H. P., & Ron, D. Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response. Nat. Cell Biol. 2, 326-332 (2000).
-
(2000)
Nat. Cell Biol
, vol.2
, pp. 326-332
-
-
Bertolotti, A.1
Zhang, Y.2
Hendershot, L.M.3
Harding, H.P.4
Ron, D.5
-
13
-
-
0027305620
-
A transmembrane protein with a cdc2+/cdc28-related kinase activity is required for signaling from the er to the nucleus
-
Mori, K., Ma, W., Gething, M. J., & Sambrook, J. A transmembrane protein with a cdc2+/CDC28-related kinase activity is required for signaling from the ER to the nucleus. Cell. 74, 743-756 (1993).
-
(1993)
Cell
, vol.74
, pp. 743-756
-
-
Mori, K.1
Ma, W.2
Gething, M.J.3
Sambrook, J.4
-
14
-
-
0027324844
-
Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinase
-
Cox, J. S., Shamu, C. E., & Walter, P. Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinase. Cell. 73, 1197-1206 (1993).
-
(1993)
Cell
, vol.73
, pp. 1197-1206
-
-
Cox, J.S.1
Shamu, C.E.2
Walter, P.3
-
15
-
-
82255173966
-
The unfolded protein response: From stress pathway to homeostatic regulation
-
Walter, P., & Ron, D. The unfolded protein response: from stress pathway to homeostatic regulation. Science. 334, 1081-1086 (2011).
-
(2011)
Science
, vol.334
, pp. 1081-1086
-
-
Walter, P.1
Ron, D.2
-
16
-
-
78449280687
-
Emerging roles for xbp1, a super transcription factor
-
He, Y., et al. Emerging roles for XBP1, a sUPeR transcription factor. Gene Expr. 15, 13-25 (2010).
-
(2010)
Gene Expr
, vol.15
, pp. 13-25
-
-
He, Y.1
-
17
-
-
50249086073
-
Xbp1 links er stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease
-
Kaser, A., et al. XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease. Cell. 134, 743-756 (2008).
-
(2008)
Cell
, vol.134
, pp. 743-756
-
-
Kaser, A.1
-
18
-
-
84887621906
-
Paneth cells as a site of origin for intestinal inflammation
-
Adolph, T. E., et al. Paneth cells as a site of origin for intestinal inflammation. Nature 503, 272-276 (2013).
-
(2013)
Nature
, vol.503
, pp. 272-276
-
-
Adolph, T.E.1
-
19
-
-
9144239817
-
Human hrd1 is an e3 ubiquitin ligase involved in degradation of proteins from the endoplasmic reticulum
-
Kikkert, M., et al. Human HRD1 is an E3 ubiquitin ligase involved in degradation of proteins from the endoplasmic reticulum. J. Biol. Chem. 279, 3525-3534 (2004).
-
(2004)
J. Biol. Chem
, vol.279
, pp. 3525-3534
-
-
Kikkert, M.1
-
20
-
-
24944552879
-
Yos9p detects and targets misfolded glycoproteins for er-Associated degradation
-
Kim, W., Spear, E. D., & Ng, D. T. Yos9p detects and targets misfolded glycoproteins for ER-Associated degradation. Mol. Cell. 19, 753-764 (2005).
-
(2005)
Mol. Cell
, vol.19
, pp. 753-764
-
-
Kim, W.1
Spear, E.D.2
Ng, D.T.3
-
21
-
-
24944583185
-
Exploration of the topological requirements of erad identifies yos9p as a lectin sensor of misfolded glycoproteins in the er lumen
-
Bhamidipati, A., Denic, V., Quan, E. M., & Weissman, J. S. Exploration of the topological requirements of ERAD identifies Yos9p as a lectin sensor of misfolded glycoproteins in the ER lumen. Mol. Cell. 19, 741-751 (2005).
-
(2005)
Mol. Cell
, vol.19
, pp. 741-751
-
-
Bhamidipati, A.1
Denic, V.2
Quan, E.M.3
Weissman, J.S.4
-
22
-
-
64749087257
-
Misfolded membrane proteins are specifically recognized by the transmembrane domain of the hrd1p ubiquitin ligase
-
Sato, B. K., Schulz, D., Do, P. H., & Hampton, R. Y. Misfolded membrane proteins are specifically recognized by the transmembrane domain of the Hrd1p ubiquitin ligase. Mol. Cell. 34, 212-222 (2009).
-
(2009)
Mol. Cell
, vol.34
, pp. 212-222
-
-
Sato, B.K.1
Schulz, D.2
Do, P.H.3
Hampton, R.Y.4
-
23
-
-
0033208953
-
Role and regulation of the er chaperone bip
-
Gething, M. J. Role and regulation of the ER chaperone BiP. Semin. Cell Dev. Biol. 10, 465-472 (1999).
-
(1999)
Semin. Cell Dev. Biol
, vol.10
, pp. 465-472
-
-
Gething, M.J.1
-
24
-
-
33749522548
-
Ab5 subtilase cytotoxin inactivates the endoplasmic reticulum chaperone bip
-
Paton, A. W., et al. AB5 subtilase cytotoxin inactivates the endoplasmic reticulum chaperone BiP. Nature. 443, 548-552 (2006).
-
(2006)
Nature
, vol.443
, pp. 548-552
-
-
Paton, A.W.1
-
25
-
-
33749233991
-
The crystal structure of human ire1 luminal domain reveals a conserved dimerization interface required for activation of the unfolded protein response
-
Zhou, J., et al. The crystal structure of human IRE1 luminal domain reveals a conserved dimerization interface required for activation of the unfolded protein response. Proc. Natl Acad. Sci. USA. 103, 14343-14348 (2006).
-
(2006)
Proc. Natl Acad. Sci. USA
, vol.103
, pp. 14343-14348
-
-
Zhou, J.1
-
26
-
-
80052227409
-
A conserved structural determinant located at the interdomain region of mammalian inositol-requiring enzyme 1alpha
-
Xue, Z., et al. A conserved structural determinant located at the interdomain region of mammalian inositol-requiring enzyme 1alpha. J. Biol. Chem. 286, 30859-30866 (2011).
-
(2011)
J. Biol. Chem
, vol.286
, pp. 30859-30866
-
-
Xue, Z.1
-
27
-
-
66049108823
-
The ire1-xbp1 pathway of the unfolded protein response is required for adipogenesis
-
Sha, H., et al. The IRE1-XBP1 pathway of the unfolded protein response is required for adipogenesis. Cell Metab. 9, 556-564 (2009).
-
(2009)
Cell Metab
, vol.9
, pp. 556-564
-
-
Sha, H.1
-
28
-
-
79251504265
-
Detecting and quantitating physiological endoplasmic reticulum stress
-
Qi, L., Yang, L., & Chen, H. Detecting and quantitating physiological endoplasmic reticulum stress. Methods Enzymol. 490, 137-146 (2011).
-
(2011)
Methods Enzymol
, vol.490
, pp. 137-146
-
-
Qi, L.1
Yang, L.2
Chen, H.3
-
29
-
-
77955342864
-
A phos-Tag-based method reveals the extent of physiological endoplasmic reticulum stress
-
Yang, L., et al. A Phos-Tag-based method reveals the extent of physiological endoplasmic reticulum stress. PLoS ONE. 5, e11621 (2010).
-
(2010)
PLoS ONE
, vol.5
, pp. e11621
-
-
Yang, L.1
-
30
-
-
0025181580
-
A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice
-
Okayasu, I., et al. A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice. Gastroenterology. 98, 694-702 (1990).
-
(1990)
Gastroenterology
, vol.98
, pp. 694-702
-
-
Okayasu, I.1
-
31
-
-
84925622906
-
Inflammation-Associated adherent-invasive Escherichia coli are enriched in pathways for use of propanediol and iron and m-cell translocation
-
Dogan, B., et al. Inflammation-Associated adherent-invasive Escherichia coli are enriched in pathways for use of propanediol and iron and M-cell translocation. Inflamm. Bowel Dis. 20, 1919-1932 (2014).
-
(2014)
Inflamm. Bowel Dis
, vol.20
, pp. 1919-1932
-
-
Dogan, B.1
-
32
-
-
84864366225
-
Inflammation drives dysbiosis and bacterial invasion in murine models of ileal Crohns disease
-
Craven, M., et al. Inflammation drives dysbiosis and bacterial invasion in murine models of ileal Crohns disease. PLoS ONE. 7, e41594 (2012).
-
(2012)
PLoS ONE
, vol.7
, pp. e41594
-
-
Craven, M.1
-
34
-
-
0025120211
-
Regulation of the mevalonate pathway
-
Goldstein, J. L., & Brown, M. S. Regulation of the mevalonate pathway. Nature. 343, 425-430 (1990).
-
(1990)
Nature
, vol.343
, pp. 425-430
-
-
Goldstein, J.L.1
Brown, M.S.2
-
35
-
-
84885647401
-
Glycosylation-independent erad pathway serves as a backup system under er stress
-
Ushioda, R., Hoseki, J., & Nagata, K. Glycosylation-independent ERAD pathway serves as a backup system under ER stress. Mol. Biol. Cell. 24, 3155-3163 (2013).
-
(2013)
Mol. Biol. Cell
, vol.24
, pp. 3155-3163
-
-
Ushioda, R.1
Hoseki, J.2
Nagata, K.3
-
36
-
-
84905253325
-
The final moments of misfolded proteins en route to the proteasome
-
Zhang, T., & Ye, Y. The final moments of misfolded proteins en route to the proteasome. DNA Cell Biol. 33, 477-483 (2014).
-
(2014)
DNA Cell Biol
, vol.33
, pp. 477-483
-
-
Zhang, T.1
Ye, Y.2
-
37
-
-
1842409617
-
Mutant analysis links the translocon and bip to retrograde protein transport for er degradation
-
Plemper, R. K., Bohmler, S., Bordallo, J., Sommer, T., & Wolf, D. H. Mutant analysis links the translocon and BiP to retrograde protein transport for ER degradation. Nature. 388, 891-895 (1997).
-
(1997)
Nature
, vol.388
, pp. 891-895
-
-
Plemper, R.K.1
Bohmler, S.2
Bordallo, J.3
Sommer, T.4
Wolf, D.H.5
-
38
-
-
0033525198
-
The requirement for molecular chaperones during endoplasmic reticulum-Associated protein degradation demonstrates that protein export and import are mechanistically distinct
-
Brodsky, J. L., et al. The requirement for molecular chaperones during endoplasmic reticulum-Associated protein degradation demonstrates that protein export and import are mechanistically distinct. J. Biol. Chem. 274, 3453-3460 (1999).
-
(1999)
J. Biol. Chem
, vol.274
, pp. 3453-3460
-
-
Brodsky, J.L.1
-
39
-
-
36249022750
-
Characterization of an erad pathway for nonglycosylated bip substrates, which require herp
-
Okuda-Shimizu, Y., & Hendershot, L. M. Characterization of an ERAD pathway for nonglycosylated BiP substrates, which require Herp. Mol. Cell. 28, 544-554 (2007).
-
(2007)
Mol. Cell
, vol.28
, pp. 544-554
-
-
Okuda-Shimizu, Y.1
Hendershot, L.M.2
-
40
-
-
66349091311
-
The protein disulfide isomerase agr2 is essential for production of intestinal mucus
-
Park, S. W., et al. The protein disulfide isomerase AGR2 is essential for production of intestinal mucus. Proc. Natl Acad. Sci. USA. 106, 6950-6955 (2009).
-
(2009)
Proc. Natl Acad. Sci. USA
, vol.106
, pp. 6950-6955
-
-
Park, S.W.1
-
41
-
-
74749103667
-
Disruption of paneth and goblet cell homeostasis and increased endoplasmic reticulum stress in agr2-/- mice
-
Zhao, F., et al. Disruption of Paneth and goblet cell homeostasis and increased endoplasmic reticulum stress in Agr2-/- mice. Dev. Biol. 338, 270-279 (2010).
-
(2010)
Dev. Biol
, vol.338
, pp. 270-279
-
-
Zhao, F.1
-
42
-
-
84898874270
-
Hrd1 suppresses nrf2-mediated cellular protection during liver cirrhosis
-
Wu, T., et al. Hrd1 suppresses Nrf2-mediated cellular protection during liver cirrhosis. Genes Dev. 28, 708-722 (2014).
-
(2014)
Genes Dev
, vol.28
, pp. 708-722
-
-
Wu, T.1
-
43
-
-
70349756962
-
Function of ire1 alpha in the placenta is essential for placental development and embryonic viability
-
Iwawaki, T., Akai, R., Yamanaka, S., & Kohno, K. Function of IRE1 alpha in the placenta is essential for placental development and embryonic viability. Proc. Natl Acad. Sci. USA. 106, 16657-16662 (2009).
-
(2009)
Proc. Natl Acad. Sci. USA
, vol.106
, pp. 16657-16662
-
-
Iwawaki, T.1
Akai, R.2
Yamanaka, S.3
Kohno, K.4
-
44
-
-
20044394518
-
Essential role of synoviolin in embryogenesis
-
Yagishita, N., et al. Essential role of synoviolin in embryogenesis. J. Biol. Chem. 280, 7909-7916 (2005).
-
(2005)
J. Biol. Chem
, vol.280
, pp. 7909-7916
-
-
Yagishita, N.1
-
45
-
-
0029769296
-
Transimmortalized mouse intestinal cells (m-icc12) that maintain a crypt phenotype
-
Bens, M., et al. Transimmortalized mouse intestinal cells (m-ICc12) that maintain a crypt phenotype. Am. J. Physiol. 270, C1666-C1674 (1996).
-
(1996)
Am. J. Physiol
, vol.270
, pp. C1666-C1674
-
-
Bens, M.1
-
46
-
-
80655124696
-
The muc13 cell-surface mucin protects against intestinal inflammation by inhibiting epithelial cell apoptosis
-
Sheng, Y. H., et al. The MUC13 cell-surface mucin protects against intestinal inflammation by inhibiting epithelial cell apoptosis. Gut. 60, 1661-1670 (2011).
-
(2011)
Gut
, vol.60
, pp. 1661-1670
-
-
Sheng, Y.H.1
-
47
-
-
84870808965
-
Non-muscle myosin iib links cytoskeleton to ire1 signaling during er stress
-
He, Y., et al. Non-muscle myosin IIB links cytoskeleton to IRE1 signaling during ER stress. Dev. Cell. 23, 1141-1152 (2012).
-
(2012)
Dev. Cell
, vol.23
, pp. 1141-1152
-
-
He, Y.1
-
48
-
-
0035923665
-
Sp600125, an anthrapyrazolone inhibitor of jun n-Terminal kinase
-
Bennett, B. L., et al. SP600125, an anthrapyrazolone inhibitor of Jun N-Terminal kinase. Proc. Natl Acad. Sci. USA. 98, 13681-13686 (2001).
-
(2001)
Proc. Natl Acad. Sci. USA
, vol.98
, pp. 13681-13686
-
-
Bennett, B.L.1
-
49
-
-
77951645463
-
A crucial role for rack1 in the regulation of glucose-stimulated ire1alpha activation in pancreatic beta cells
-
ra7
-
Qiu, Y., et al. A crucial role for RACK1 in the regulation of glucose-stimulated IRE1alpha activation in pancreatic beta cells. Sci. Signal. 3, ra7 (2010).
-
(2010)
Sci. Signal
, vol.3
-
-
Qiu, Y.1
-
50
-
-
34347262689
-
Chemically induced mouse models of intestinal inflammation
-
Wirtz, S., Neufert, C., Weigmann, B., & Neurath, M. F. Chemically induced mouse models of intestinal inflammation. Nat. Protoc. 2, 541-546 (2007).
-
(2007)
Nat. Protoc
, vol.2
, pp. 541-546
-
-
Wirtz, S.1
Neufert, C.2
Weigmann, B.3
Neurath, M.F.4
-
51
-
-
84904069723
-
Diet-induced alterations in gut microflora contribute to lethal pulmonary damage in tlr2/tlr4-deficient mice
-
Ji, Y., et al. Diet-induced alterations in gut microflora contribute to lethal pulmonary damage in TLR2/TLR4-deficient mice. Cell Rep. 8, 137-149 (2014).
-
(2014)
Cell Rep
, vol.8
, pp. 137-149
-
-
Ji, Y.1
-
52
-
-
79959538608
-
Gr-1+ cd11b+ myeloid-derived suppressor cells suppress inflammation and promote insulin sensitivity in obesity
-
Xia, S., et al. Gr-1+ CD11b+ myeloid-derived suppressor cells suppress inflammation and promote insulin sensitivity in obesity. J. Biol. Chem. 286, 23591-23599 (2011).
-
(2011)
J. Biol. Chem
, vol.286
, pp. 23591-23599
-
-
Xia, S.1
-
53
-
-
67349123408
-
Single lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche
-
Sato, T., et al. Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche. Nature. 459, 262-265 (2009).
-
(2009)
Nature
, vol.459
, pp. 262-265
-
-
Sato, T.1
-
54
-
-
84861869574
-
The atp-p2x7 signaling axis is dispensable for obesity-Associated inflammasome activation in adipose tissue
-
Sun, S., Xia, S., Ji, Y., Kersten, S., & Qi, L. The ATP-P2X7 signaling axis is dispensable for obesity-Associated inflammasome activation in adipose tissue. Diabetes. 61, 1471-1478 (2012).
-
(2012)
Diabetes
, vol.61
, pp. 1471-1478
-
-
Sun, S.1
Xia, S.2
Ji, Y.3
Kersten, S.4
Qi, L.5
|