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Volumn 17, Issue 12, 2015, Pages 1546-1555

IRE1α is an endogenous substrate of endoplasmic-reticulum-associated degradation

(26)  Sun, Shengyi a   Shi, Guojun a   Sha, Haibo a   Ji, Yewei a   Han, Xuemei b   Shu, Xin a   Ma, Hongming c   Inoue, Takamasa d   Gao, Beixue e   Kim, Hana a   Bu, Pengcheng f   Guber, Robert D a   Shen, Xiling f,g   Lee, Ann Hwee h   Iwawaki, Takao i   Paton, Adrienne W j   Paton, James C j   Fang, Deyu e   Tsai, Billy d   Yates III, John R b   more..


Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; CELL PROTEIN; GLUCOSE REGULATED PROTEIN 78; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; IRE1ALPHA PROTEIN; MULTIPROTEIN COMPLEX; OS9 PROTEIN; PROTEIN IRE1; SEL1L HRD1 ERAD COMPLEX; SEL1L PROTEIN; UNCLASSIFIED DRUG; ERN1 PROTEIN, MOUSE; HEAT SHOCK PROTEIN; LECTIN; MOLECULAR CHAPERONE GRP78; OS9 PROTEIN, MOUSE; PROTEIN; PROTEIN SERINE THREONINE KINASE; RIBONUCLEASE; SEL1H PROTEIN, MOUSE; SYVN1 PROTEIN, MOUSE; TUMOR PROTEIN; UBIQUITIN PROTEIN LIGASE;

EID: 84948712979     PISSN: 14657392     EISSN: 14764679     Source Type: Journal    
DOI: 10.1038/ncb3266     Document Type: Article
Times cited : (176)

References (54)
  • 1
    • 84860118506 scopus 로고    scopus 로고
    • The delicate balance between secreted protein folding and endoplasmic reticulum-Associated degradation in human physiology
    • Guerriero, C. J., & Brodsky, J. L. The delicate balance between secreted protein folding and endoplasmic reticulum-Associated degradation in human physiology. Physiol. Rev. 92, 537-576 (2012).
    • (2012) Physiol. Rev , vol.92 , pp. 537-576
    • Guerriero, C.J.1    Brodsky, J.L.2
  • 3
    • 0029811218 scopus 로고    scopus 로고
    • Role of 26s proteasome and hrd genes in the degradation of 3-hydroxy-3-methylglutaryl-coa reductase, an integral endoplasmic reticulum membrane protein
    • Hampton, R. Y., Gardner, R. G., & Rine, J. Role of 26S proteasome and HRD genes in the degradation of 3-hydroxy-3-methylglutaryl-CoA reductase, an integral endoplasmic reticulum membrane protein. Mol. Biol. Cell. 7, 2029-2044 (1996).
    • (1996) Mol. Biol. Cell , vol.7 , pp. 2029-2044
    • Hampton, R.Y.1    Gardner, R.G.2    Rine, J.3
  • 4
    • 84255169603 scopus 로고    scopus 로고
    • Defining human erad networks through an integrative mapping strategy
    • Christianson, J. C., et al. Defining human ERAD networks through an integrative mapping strategy. Nat. Cell Biol. 14, 93-105 (2012).
    • (2012) Nat. Cell Biol , vol.14 , pp. 93-105
    • Christianson, J.C.1
  • 5
    • 33750359201 scopus 로고    scopus 로고
    • SEL1Lfeti the homologue of yeast Hrd3p, is involved in protein dislocation from the mammalian ER
    • Mueller, B., Lilley, B. N., & Ploegh, H. L. SEL1L, the homologue of yeast Hrd3p, is involved in protein dislocation from the mammalian ER. J. Cell Biol. 175, 261-270 (2006).
    • (2006) J. Cell Biol , vol.175 , pp. 261-270
    • Mueller, B.1    Lilley, B.N.2    Ploegh, H.L.3
  • 6
    • 0034597161 scopus 로고    scopus 로고
    • Endoplasmic reticulum degradation requires lumen to cytosol signaling transmembrane control of hrd1p by hrd3p
    • Gardner, R. G., et al. Endoplasmic reticulum degradation requires lumen to cytosol signaling. Transmembrane control of Hrd1p by Hrd3p. J. Cell Biol. 151, 69-82 (2000).
    • (2000) J. Cell Biol , vol.151 , pp. 69-82
    • Gardner, R.G.1
  • 7
    • 0033492290 scopus 로고    scopus 로고
    • Genetic interactions of hrd3p and der3p/hrd1p with sec61p suggest a retro-Translocation complex mediating protein transport for er degradation
    • Plemper, R. K., et al. Genetic interactions of Hrd3p and Der3p/Hrd1p with Sec61p suggest a retro-Translocation complex mediating protein transport for ER degradation. J. Cell Sci. 112, 4123-4134 (1999).
    • (1999) J. Cell Sci , vol.112 , pp. 4123-4134
    • Plemper, R.K.1
  • 8
    • 33746228127 scopus 로고    scopus 로고
    • Distinct ubiquitin-ligase complexes define convergent pathways for the degradation of er proteins
    • Carvalho, P., Goder, V., & Rapoport, T. A. Distinct ubiquitin-ligase complexes define convergent pathways for the degradation of ER proteins. Cell. 126, 361-373 (2006).
    • (2006) Cell , vol.126 , pp. 361-373
    • Carvalho, P.1    Goder, V.2    Rapoport, T.A.3
  • 9
    • 50449107542 scopus 로고    scopus 로고
    • Sel1l nucleates a protein complex required for dislocation of misfolded glycoproteins
    • Mueller, B., Klemm, E. J., Spooner, E., Claessen, J. H., & Ploegh, H. L. SEL1L nucleates a protein complex required for dislocation of misfolded glycoproteins. Proc. Natl Acad. Sci. USA. 105, 12325-12330 (2008).
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 12325-12330
    • Mueller, B.1    Klemm, E.J.2    Spooner, E.3    Claessen, J.H.4    Ploegh, H.L.5
  • 10
    • 84893517295 scopus 로고    scopus 로고
    • Sel1l is indispensable for mammalian endoplasmic reticulumassociated degradation, endoplasmic reticulum homeostasis, and survival
    • Sun, S., et al. Sel1L is indispensable for mammalian endoplasmic reticulumassociated degradation, endoplasmic reticulum homeostasis, and survival. Proc. Natl Acad. Sci. USA. 111, E582-E591 (2014).
    • (2014) Proc. Natl Acad. Sci. USA , vol.111 , pp. E582-E591
    • Sun, S.1
  • 11
    • 84913536702 scopus 로고    scopus 로고
    • The er-Associated degradation adaptor protein sel1l regulates lpl secretion and lipid metabolism
    • Sha, H., et al. The ER-Associated degradation adaptor protein Sel1L regulates LPL secretion and lipid metabolism. Cell Metab. 20, 458-470 (2014).
    • (2014) Cell Metab , vol.20 , pp. 458-470
    • Sha, H.1
  • 12
    • 0033782015 scopus 로고    scopus 로고
    • Dynamic interaction of bip and er stress transducers in the unfolded-protein response
    • Bertolotti, A., Zhang, Y., Hendershot, L. M., Harding, H. P., & Ron, D. Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response. Nat. Cell Biol. 2, 326-332 (2000).
    • (2000) Nat. Cell Biol , vol.2 , pp. 326-332
    • Bertolotti, A.1    Zhang, Y.2    Hendershot, L.M.3    Harding, H.P.4    Ron, D.5
  • 13
    • 0027305620 scopus 로고
    • A transmembrane protein with a cdc2+/cdc28-related kinase activity is required for signaling from the er to the nucleus
    • Mori, K., Ma, W., Gething, M. J., & Sambrook, J. A transmembrane protein with a cdc2+/CDC28-related kinase activity is required for signaling from the ER to the nucleus. Cell. 74, 743-756 (1993).
    • (1993) Cell , vol.74 , pp. 743-756
    • Mori, K.1    Ma, W.2    Gething, M.J.3    Sambrook, J.4
  • 14
    • 0027324844 scopus 로고
    • Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinase
    • Cox, J. S., Shamu, C. E., & Walter, P. Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinase. Cell. 73, 1197-1206 (1993).
    • (1993) Cell , vol.73 , pp. 1197-1206
    • Cox, J.S.1    Shamu, C.E.2    Walter, P.3
  • 15
    • 82255173966 scopus 로고    scopus 로고
    • The unfolded protein response: From stress pathway to homeostatic regulation
    • Walter, P., & Ron, D. The unfolded protein response: from stress pathway to homeostatic regulation. Science. 334, 1081-1086 (2011).
    • (2011) Science , vol.334 , pp. 1081-1086
    • Walter, P.1    Ron, D.2
  • 16
    • 78449280687 scopus 로고    scopus 로고
    • Emerging roles for xbp1, a super transcription factor
    • He, Y., et al. Emerging roles for XBP1, a sUPeR transcription factor. Gene Expr. 15, 13-25 (2010).
    • (2010) Gene Expr , vol.15 , pp. 13-25
    • He, Y.1
  • 17
    • 50249086073 scopus 로고    scopus 로고
    • Xbp1 links er stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease
    • Kaser, A., et al. XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease. Cell. 134, 743-756 (2008).
    • (2008) Cell , vol.134 , pp. 743-756
    • Kaser, A.1
  • 18
    • 84887621906 scopus 로고    scopus 로고
    • Paneth cells as a site of origin for intestinal inflammation
    • Adolph, T. E., et al. Paneth cells as a site of origin for intestinal inflammation. Nature 503, 272-276 (2013).
    • (2013) Nature , vol.503 , pp. 272-276
    • Adolph, T.E.1
  • 19
    • 9144239817 scopus 로고    scopus 로고
    • Human hrd1 is an e3 ubiquitin ligase involved in degradation of proteins from the endoplasmic reticulum
    • Kikkert, M., et al. Human HRD1 is an E3 ubiquitin ligase involved in degradation of proteins from the endoplasmic reticulum. J. Biol. Chem. 279, 3525-3534 (2004).
    • (2004) J. Biol. Chem , vol.279 , pp. 3525-3534
    • Kikkert, M.1
  • 20
    • 24944552879 scopus 로고    scopus 로고
    • Yos9p detects and targets misfolded glycoproteins for er-Associated degradation
    • Kim, W., Spear, E. D., & Ng, D. T. Yos9p detects and targets misfolded glycoproteins for ER-Associated degradation. Mol. Cell. 19, 753-764 (2005).
    • (2005) Mol. Cell , vol.19 , pp. 753-764
    • Kim, W.1    Spear, E.D.2    Ng, D.T.3
  • 21
    • 24944583185 scopus 로고    scopus 로고
    • Exploration of the topological requirements of erad identifies yos9p as a lectin sensor of misfolded glycoproteins in the er lumen
    • Bhamidipati, A., Denic, V., Quan, E. M., & Weissman, J. S. Exploration of the topological requirements of ERAD identifies Yos9p as a lectin sensor of misfolded glycoproteins in the ER lumen. Mol. Cell. 19, 741-751 (2005).
    • (2005) Mol. Cell , vol.19 , pp. 741-751
    • Bhamidipati, A.1    Denic, V.2    Quan, E.M.3    Weissman, J.S.4
  • 22
    • 64749087257 scopus 로고    scopus 로고
    • Misfolded membrane proteins are specifically recognized by the transmembrane domain of the hrd1p ubiquitin ligase
    • Sato, B. K., Schulz, D., Do, P. H., & Hampton, R. Y. Misfolded membrane proteins are specifically recognized by the transmembrane domain of the Hrd1p ubiquitin ligase. Mol. Cell. 34, 212-222 (2009).
    • (2009) Mol. Cell , vol.34 , pp. 212-222
    • Sato, B.K.1    Schulz, D.2    Do, P.H.3    Hampton, R.Y.4
  • 23
    • 0033208953 scopus 로고    scopus 로고
    • Role and regulation of the er chaperone bip
    • Gething, M. J. Role and regulation of the ER chaperone BiP. Semin. Cell Dev. Biol. 10, 465-472 (1999).
    • (1999) Semin. Cell Dev. Biol , vol.10 , pp. 465-472
    • Gething, M.J.1
  • 24
    • 33749522548 scopus 로고    scopus 로고
    • Ab5 subtilase cytotoxin inactivates the endoplasmic reticulum chaperone bip
    • Paton, A. W., et al. AB5 subtilase cytotoxin inactivates the endoplasmic reticulum chaperone BiP. Nature. 443, 548-552 (2006).
    • (2006) Nature , vol.443 , pp. 548-552
    • Paton, A.W.1
  • 25
    • 33749233991 scopus 로고    scopus 로고
    • The crystal structure of human ire1 luminal domain reveals a conserved dimerization interface required for activation of the unfolded protein response
    • Zhou, J., et al. The crystal structure of human IRE1 luminal domain reveals a conserved dimerization interface required for activation of the unfolded protein response. Proc. Natl Acad. Sci. USA. 103, 14343-14348 (2006).
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , pp. 14343-14348
    • Zhou, J.1
  • 26
    • 80052227409 scopus 로고    scopus 로고
    • A conserved structural determinant located at the interdomain region of mammalian inositol-requiring enzyme 1alpha
    • Xue, Z., et al. A conserved structural determinant located at the interdomain region of mammalian inositol-requiring enzyme 1alpha. J. Biol. Chem. 286, 30859-30866 (2011).
    • (2011) J. Biol. Chem , vol.286 , pp. 30859-30866
    • Xue, Z.1
  • 27
    • 66049108823 scopus 로고    scopus 로고
    • The ire1-xbp1 pathway of the unfolded protein response is required for adipogenesis
    • Sha, H., et al. The IRE1-XBP1 pathway of the unfolded protein response is required for adipogenesis. Cell Metab. 9, 556-564 (2009).
    • (2009) Cell Metab , vol.9 , pp. 556-564
    • Sha, H.1
  • 28
    • 79251504265 scopus 로고    scopus 로고
    • Detecting and quantitating physiological endoplasmic reticulum stress
    • Qi, L., Yang, L., & Chen, H. Detecting and quantitating physiological endoplasmic reticulum stress. Methods Enzymol. 490, 137-146 (2011).
    • (2011) Methods Enzymol , vol.490 , pp. 137-146
    • Qi, L.1    Yang, L.2    Chen, H.3
  • 29
    • 77955342864 scopus 로고    scopus 로고
    • A phos-Tag-based method reveals the extent of physiological endoplasmic reticulum stress
    • Yang, L., et al. A Phos-Tag-based method reveals the extent of physiological endoplasmic reticulum stress. PLoS ONE. 5, e11621 (2010).
    • (2010) PLoS ONE , vol.5 , pp. e11621
    • Yang, L.1
  • 30
    • 0025181580 scopus 로고
    • A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice
    • Okayasu, I., et al. A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice. Gastroenterology. 98, 694-702 (1990).
    • (1990) Gastroenterology , vol.98 , pp. 694-702
    • Okayasu, I.1
  • 31
    • 84925622906 scopus 로고    scopus 로고
    • Inflammation-Associated adherent-invasive Escherichia coli are enriched in pathways for use of propanediol and iron and m-cell translocation
    • Dogan, B., et al. Inflammation-Associated adherent-invasive Escherichia coli are enriched in pathways for use of propanediol and iron and M-cell translocation. Inflamm. Bowel Dis. 20, 1919-1932 (2014).
    • (2014) Inflamm. Bowel Dis , vol.20 , pp. 1919-1932
    • Dogan, B.1
  • 32
    • 84864366225 scopus 로고    scopus 로고
    • Inflammation drives dysbiosis and bacterial invasion in murine models of ileal Crohns disease
    • Craven, M., et al. Inflammation drives dysbiosis and bacterial invasion in murine models of ileal Crohns disease. PLoS ONE. 7, e41594 (2012).
    • (2012) PLoS ONE , vol.7 , pp. e41594
    • Craven, M.1
  • 34
    • 0025120211 scopus 로고
    • Regulation of the mevalonate pathway
    • Goldstein, J. L., & Brown, M. S. Regulation of the mevalonate pathway. Nature. 343, 425-430 (1990).
    • (1990) Nature , vol.343 , pp. 425-430
    • Goldstein, J.L.1    Brown, M.S.2
  • 35
    • 84885647401 scopus 로고    scopus 로고
    • Glycosylation-independent erad pathway serves as a backup system under er stress
    • Ushioda, R., Hoseki, J., & Nagata, K. Glycosylation-independent ERAD pathway serves as a backup system under ER stress. Mol. Biol. Cell. 24, 3155-3163 (2013).
    • (2013) Mol. Biol. Cell , vol.24 , pp. 3155-3163
    • Ushioda, R.1    Hoseki, J.2    Nagata, K.3
  • 36
    • 84905253325 scopus 로고    scopus 로고
    • The final moments of misfolded proteins en route to the proteasome
    • Zhang, T., & Ye, Y. The final moments of misfolded proteins en route to the proteasome. DNA Cell Biol. 33, 477-483 (2014).
    • (2014) DNA Cell Biol , vol.33 , pp. 477-483
    • Zhang, T.1    Ye, Y.2
  • 37
    • 1842409617 scopus 로고    scopus 로고
    • Mutant analysis links the translocon and bip to retrograde protein transport for er degradation
    • Plemper, R. K., Bohmler, S., Bordallo, J., Sommer, T., & Wolf, D. H. Mutant analysis links the translocon and BiP to retrograde protein transport for ER degradation. Nature. 388, 891-895 (1997).
    • (1997) Nature , vol.388 , pp. 891-895
    • Plemper, R.K.1    Bohmler, S.2    Bordallo, J.3    Sommer, T.4    Wolf, D.H.5
  • 38
    • 0033525198 scopus 로고    scopus 로고
    • The requirement for molecular chaperones during endoplasmic reticulum-Associated protein degradation demonstrates that protein export and import are mechanistically distinct
    • Brodsky, J. L., et al. The requirement for molecular chaperones during endoplasmic reticulum-Associated protein degradation demonstrates that protein export and import are mechanistically distinct. J. Biol. Chem. 274, 3453-3460 (1999).
    • (1999) J. Biol. Chem , vol.274 , pp. 3453-3460
    • Brodsky, J.L.1
  • 39
    • 36249022750 scopus 로고    scopus 로고
    • Characterization of an erad pathway for nonglycosylated bip substrates, which require herp
    • Okuda-Shimizu, Y., & Hendershot, L. M. Characterization of an ERAD pathway for nonglycosylated BiP substrates, which require Herp. Mol. Cell. 28, 544-554 (2007).
    • (2007) Mol. Cell , vol.28 , pp. 544-554
    • Okuda-Shimizu, Y.1    Hendershot, L.M.2
  • 40
    • 66349091311 scopus 로고    scopus 로고
    • The protein disulfide isomerase agr2 is essential for production of intestinal mucus
    • Park, S. W., et al. The protein disulfide isomerase AGR2 is essential for production of intestinal mucus. Proc. Natl Acad. Sci. USA. 106, 6950-6955 (2009).
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 6950-6955
    • Park, S.W.1
  • 41
    • 74749103667 scopus 로고    scopus 로고
    • Disruption of paneth and goblet cell homeostasis and increased endoplasmic reticulum stress in agr2-/- mice
    • Zhao, F., et al. Disruption of Paneth and goblet cell homeostasis and increased endoplasmic reticulum stress in Agr2-/- mice. Dev. Biol. 338, 270-279 (2010).
    • (2010) Dev. Biol , vol.338 , pp. 270-279
    • Zhao, F.1
  • 42
    • 84898874270 scopus 로고    scopus 로고
    • Hrd1 suppresses nrf2-mediated cellular protection during liver cirrhosis
    • Wu, T., et al. Hrd1 suppresses Nrf2-mediated cellular protection during liver cirrhosis. Genes Dev. 28, 708-722 (2014).
    • (2014) Genes Dev , vol.28 , pp. 708-722
    • Wu, T.1
  • 43
    • 70349756962 scopus 로고    scopus 로고
    • Function of ire1 alpha in the placenta is essential for placental development and embryonic viability
    • Iwawaki, T., Akai, R., Yamanaka, S., & Kohno, K. Function of IRE1 alpha in the placenta is essential for placental development and embryonic viability. Proc. Natl Acad. Sci. USA. 106, 16657-16662 (2009).
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 16657-16662
    • Iwawaki, T.1    Akai, R.2    Yamanaka, S.3    Kohno, K.4
  • 44
    • 20044394518 scopus 로고    scopus 로고
    • Essential role of synoviolin in embryogenesis
    • Yagishita, N., et al. Essential role of synoviolin in embryogenesis. J. Biol. Chem. 280, 7909-7916 (2005).
    • (2005) J. Biol. Chem , vol.280 , pp. 7909-7916
    • Yagishita, N.1
  • 45
    • 0029769296 scopus 로고    scopus 로고
    • Transimmortalized mouse intestinal cells (m-icc12) that maintain a crypt phenotype
    • Bens, M., et al. Transimmortalized mouse intestinal cells (m-ICc12) that maintain a crypt phenotype. Am. J. Physiol. 270, C1666-C1674 (1996).
    • (1996) Am. J. Physiol , vol.270 , pp. C1666-C1674
    • Bens, M.1
  • 46
    • 80655124696 scopus 로고    scopus 로고
    • The muc13 cell-surface mucin protects against intestinal inflammation by inhibiting epithelial cell apoptosis
    • Sheng, Y. H., et al. The MUC13 cell-surface mucin protects against intestinal inflammation by inhibiting epithelial cell apoptosis. Gut. 60, 1661-1670 (2011).
    • (2011) Gut , vol.60 , pp. 1661-1670
    • Sheng, Y.H.1
  • 47
    • 84870808965 scopus 로고    scopus 로고
    • Non-muscle myosin iib links cytoskeleton to ire1 signaling during er stress
    • He, Y., et al. Non-muscle myosin IIB links cytoskeleton to IRE1 signaling during ER stress. Dev. Cell. 23, 1141-1152 (2012).
    • (2012) Dev. Cell , vol.23 , pp. 1141-1152
    • He, Y.1
  • 48
    • 0035923665 scopus 로고    scopus 로고
    • Sp600125, an anthrapyrazolone inhibitor of jun n-Terminal kinase
    • Bennett, B. L., et al. SP600125, an anthrapyrazolone inhibitor of Jun N-Terminal kinase. Proc. Natl Acad. Sci. USA. 98, 13681-13686 (2001).
    • (2001) Proc. Natl Acad. Sci. USA , vol.98 , pp. 13681-13686
    • Bennett, B.L.1
  • 49
    • 77951645463 scopus 로고    scopus 로고
    • A crucial role for rack1 in the regulation of glucose-stimulated ire1alpha activation in pancreatic beta cells
    • ra7
    • Qiu, Y., et al. A crucial role for RACK1 in the regulation of glucose-stimulated IRE1alpha activation in pancreatic beta cells. Sci. Signal. 3, ra7 (2010).
    • (2010) Sci. Signal , vol.3
    • Qiu, Y.1
  • 50
    • 34347262689 scopus 로고    scopus 로고
    • Chemically induced mouse models of intestinal inflammation
    • Wirtz, S., Neufert, C., Weigmann, B., & Neurath, M. F. Chemically induced mouse models of intestinal inflammation. Nat. Protoc. 2, 541-546 (2007).
    • (2007) Nat. Protoc , vol.2 , pp. 541-546
    • Wirtz, S.1    Neufert, C.2    Weigmann, B.3    Neurath, M.F.4
  • 51
    • 84904069723 scopus 로고    scopus 로고
    • Diet-induced alterations in gut microflora contribute to lethal pulmonary damage in tlr2/tlr4-deficient mice
    • Ji, Y., et al. Diet-induced alterations in gut microflora contribute to lethal pulmonary damage in TLR2/TLR4-deficient mice. Cell Rep. 8, 137-149 (2014).
    • (2014) Cell Rep , vol.8 , pp. 137-149
    • Ji, Y.1
  • 52
    • 79959538608 scopus 로고    scopus 로고
    • Gr-1+ cd11b+ myeloid-derived suppressor cells suppress inflammation and promote insulin sensitivity in obesity
    • Xia, S., et al. Gr-1+ CD11b+ myeloid-derived suppressor cells suppress inflammation and promote insulin sensitivity in obesity. J. Biol. Chem. 286, 23591-23599 (2011).
    • (2011) J. Biol. Chem , vol.286 , pp. 23591-23599
    • Xia, S.1
  • 53
    • 67349123408 scopus 로고    scopus 로고
    • Single lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche
    • Sato, T., et al. Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche. Nature. 459, 262-265 (2009).
    • (2009) Nature , vol.459 , pp. 262-265
    • Sato, T.1
  • 54
    • 84861869574 scopus 로고    scopus 로고
    • The atp-p2x7 signaling axis is dispensable for obesity-Associated inflammasome activation in adipose tissue
    • Sun, S., Xia, S., Ji, Y., Kersten, S., & Qi, L. The ATP-P2X7 signaling axis is dispensable for obesity-Associated inflammasome activation in adipose tissue. Diabetes. 61, 1471-1478 (2012).
    • (2012) Diabetes , vol.61 , pp. 1471-1478
    • Sun, S.1    Xia, S.2    Ji, Y.3    Kersten, S.4    Qi, L.5


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