A Deletion in the Canine POMC Gene Is Associated with Weight and Appetite in Obesity-Prone Labrador Retriever Dogs

Cell Metabolism

Volumn 23, Issue 5, 2016, Pages 893-900

  Raffan, Eleanor ^a   Dennis, Rowena J ^a   O'Donovan, Conor J ^a   Becker, Julia M ^a   Scott, Robert A ^b   Smith, Stephen P ^c   Withers, David J ^a   Wood, Claire J ^a   Conci, Elena ^a   Clements, Dylan N ^d,e   Summers, Kim M ^d   German, Alexander J ^f   Mellersh, Cathryn S ^g   Arendt, Maja L ^h   Iyemere, Valentine P ^a   Withers, Elaine ^a   Söder, Josefin ⁱ   Wernersson, Sara ⁱ   Andersson, Göran ⁱ   Lindblad Toh, Kerstin ^j,k   Yeo, Giles S H ^a   O'Rahilly, Stephen ^a   more..

^a MEDICAL RESEARCH COUNCIL   (United Kingdom)

^b MRC EPIDEMIOLOGY UNIT   (United Kingdom)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^d UNIVERSITY OF EDINBURGH   (United Kingdom)

^e UNIVERSITY OF EDINBURGH   (United Kingdom)

^f UNIVERSITY OF LIVERPOOL   (United Kingdom)

^g ANIMAL HEALTH TRUST   (United Kingdom)

^h UPPSALA UNIVERSITY   (Sweden)

ⁱ SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES   (Sweden)

^j BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^k SCIENCE FOR LIFE LABORATORY   (Sweden)

more..

Author keywords

[No Author keywords available]

Indexed keywords

BETA ENDORPHIN; BETA INTERMEDIN; MELANOCORTIN RECEPTOR; PROOPIOMELANOCORTIN;

APPETITE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; ENERGY; FOOD; GENE ACTIVATION; GENE DELETION; GENE FREQUENCY; GENETIC ASSOCIATION; HOMEOSTASIS; LABRADOR RETRIEVER; MOTIVATION; NONHUMAN; OBESITY; PRIORITY JOURNAL; AMINO ACID SEQUENCE; ANIMAL; BASE PAIRING; CHEMISTRY; CHLOROCEBUS AETHIOPS; COS CELL LINE; DOG; FEEDING BEHAVIOR; GENETICS; GENOTYPE; METABOLISM; NUCLEOTIDE SEQUENCE;

ADIPOSITY; AMINO ACID SEQUENCE; ANIMALS; APPETITE; BASE PAIRING; BASE SEQUENCE; BETA-MSH; BODY WEIGHT; CERCOPITHECUS AETHIOPS; COS CELLS; DOGS; FEEDING BEHAVIOR; GENE DELETION; GENOTYPE; OBESITY; PRO-OPIOMELANOCORTIN; RECEPTORS, MELANOCORTIN;

EID: 84964809696     PISSN: 15504131     EISSN: 19327420     Source Type: Journal    
DOI: 10.1016/j.cmet.2016.04.012     Document Type: Article

References (33)

1. S.M. Appleyard, M. Hayward, J.I. Young, A.A. Butler, R.D. Cone, M. Rubinstein, and M.J. Low A role for the endogenous opioid beta-endorphin in energy homeostasis Endocrinology 144 2003 1753 1760
2. B.G. Challis, L.E. Pritchard, J.W. Creemers, J. Delplanque, J.M. Keogh, J. Luan, N.J. Wareham, G.S. Yeo, S. Bhattacharyya, P. Froguel, and et al. A missense mutation disrupting a dibasic prohormone processing site in pro-opiomelanocortin (POMC) increases susceptibility to early-onset obesity through a novel molecular mechanism Hum. Mol. Genet. 11 2002 1997 2004
3. L. Colliard, J. Ancel, J.J. Benet, B.M. Paragon, and G. Blanchard Risk factors for obesity in dogs in France J. Nutr. 136 Suppl 7 2006 1951S 1954S
4. E.A. Courcier, R.M. Thomson, D.J. Mellor, and P.S. Yam An epidemiological study of environmental factors associated with canine obesity J. Small Anim. Pract. 51 2010 362 367
5. J.E.L. Day, S. Kergoat, and K. Kotrschal Do pets influence the quantity and choice of food offered to them by their owners: lessons from other animals and the pre-verbal human infant? CAB Reviews: Perspectives in Agriculture, Veterinary Science, Nutrition and Natural Resources. 4 2009 10.1079/PAVSNNR20094042
6. A.T. Edney, and P.M. Smith Study of obesity in dogs visiting veterinary practices in the United Kingdom Vet. Rec. 118 1986 391 396
7. A.J. German The growing problem of obesity in dogs and cats J. Nutr. 136 Suppl 7 2006 1940S 1946S
8. D.P. Laflamme Development and validation of a body condition score system for dogs Canine Pract. 22 1997 10 15
9. D.F. Lawler, B.T. Larson, J.M. Ballam, G.K. Smith, D.N. Biery, R.H. Evans, E.H. Greeley, M. Segre, H.D. Stowe, and R.D. Kealy Diet restriction and ageing in the dog: major observations over two decades Br. J. Nutr. 99 2008 793 805
10. Y.S. Lee, B.G. Challis, D.A. Thompson, G.S. Yeo, J.M. Keogh, M.E. Madonna, V. Wraight, M. Sims, V. Vatin, D. Meyre, and et al. A POMC variant implicates beta-melanocyte-stimulating hormone in the control of human energy balance Cell Metab. 3 2006 135 140
11. A.E. Locke, B. Kahali, S.I. Berndt, A.E. Justice, T.H. Pers, F.R. Day, C. Powell, S. Vedantam, M.L. Buchkovich, J. Yang, et al. LifeLines Cohort Study ADIPOGen Consortium AGEN-BMI Working Group CARDIOGRAMplusC4D Consortium CKDGen Consortium GLGC ICBP MAGIC Investigators MuTHER Consortium MIGen Consortium PAGE Consortium ReproGen Consortium GENIE Consortium International Endogene Consortium Genetic studies of body mass index yield new insights for obesity biology Nature 518 2015 197 206
12. E.M. Lund, P.J. Armstrong, C.A. Kirk, and J.S. Klausner Prevalence and risk factors for obesity in adult dogs from private US veterinary practices Intern J Appl Res Vet Med 4 2006 177 186
13. M. Mankowska, M. Stachowiak, A. Graczyk, P. Ciazynska, M. Gogulski, W. Nizanski, and M. Switonski Sequence analysis of three canine adipokine genes revealed an association between TNF polymorphisms and obesity in Labrador dogs Anim. Genet. 47 2016 245 249 10.1111/age.12390 Published online December 22, 2015
14. E. Mason Obesity in pet dogs Vet. Rec. 86 1970 612 616
15. D.I. Mawby, J.W. Bartges, A. d'Avignon, D.P. Laflamme, T.D. Moyers, and T. Cottrell Comparison of various methods for estimating body fat in dogs J. Am. Anim. Hosp. Assoc. 40 2004 109 114
16. P.D. McGreevy, P.C. Thomson, C. Pride, A. Fawcett, T. Grassi, and B. Jones Prevalence of obesity in dogs examined by Australian veterinary practices and the risk factors involved Vet. Rec. 156 2005 695 702
17. I.A. Mendez, S.B. Ostlund, N.T. Maidment, and N.P. Murphy Involvement of endogenous enkephalins and β-endorphin in feeding and diet-induced obesity Neuropsychopharmacology 40 2015 2103 2112
18. D.G. O Neill, D.B. Church, P.D. McGreevy, P.C. Thomson, and D.C. Brodbelt Prevalence of disorders recorded in dogs attending primary-care veterinary practices in England PLoS ONE 9 2014 e90501
19. C.A. Pugh, B.M. Bronsvoort, I.G. Handel, K.M. Summers, and D.N. Clements Dogslife: a cohort study of Labrador retrievers in the UK Prev. Vet. Med. 122 2015 426 435
20. E. Raffan The big problem: battling companion animal obesity Vet. Rec. 173 2013 287 291
21. E. Raffan, S.P. Smith, S. O'Rahilly, and J. Wardle Development, factor structure and application of the dog obesity risk and appetite (DORA) questionnaire PeerJ 3 2015 e1278
22. I.D. Robertson The association of exercise, diet and other factors with owner-perceived obesity in privately owned dogs from metropolitan Perth, WA Prev. Vet. Med. 58 2003 75 83
23. M. Sallander, M. Hagberg, A. Hedhammar, M. Rundgren, and J.E. Lindberg Energy-intake and activity risk factors for owner-perceived obesity in a defined population of Swedish dogs Prev. Vet. Med. 96 2010 132 141
24. F. Sievers, A. Wilm, D. Dineen, T.J. Gibson, K. Karplus, W. Li, R. Lopez, H. McWilliam, M. Remmert, J. Söding, and et al. Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega Mol. Syst. Biol. 7 2011 539
25. StataCorp. (2015). Stata statistical software: release 14 (StataCorp LP).
26. L. Ste Marie, G.I. Miura, D.J. Marsh, K. Yagaloff, and R.D. Palmiter A metabolic defect promotes obesity in mice lacking melanocortin-4 receptors Proc. Natl. Acad. Sci. USA 97 2000 12339 12344
27. N.B. Sutter, and E.A. Ostrander Dog star rising: the canine genetic system Nat. Rev. Genet. 5 2004 900 910
28. Y.C. Tung, G.S. Yeo, S. O'Rahilly, and A.P. Coll Obesity and FTO: changing focus at a complex locus Cell Metab. 20 2014 710 718
29. B.M. Vonholdt, J.P. Pollinger, K.E. Lohmueller, E. Han, H.G. Parker, P. Quignon, J.D. Degenhardt, A.R. Boyko, D.A. Earl, A. Auton, and et al. Genome-wide SNP and haplotype analyses reveal a rich history underlying dog domestication Nature 464 2010 898 902
30. A.K. Wong, and M.W. Neff DOGSET: pre-designed primer sets for fine-scale mapping and DNA sequence interrogation in the dog Anim. Genet. 40 2009 569 571
31. G.S. Yeo, and L.K. Heisler Unraveling the brain regulation of appetite: lessons from genetics Nat. Neurosci. 15 2012 1343 1349
32. G.S. Yeo, E.J. Lank, I.S. Farooqi, J. Keogh, B.G. Challis, and S. O'Rahilly Mutations in the human melanocortin-4 receptor gene associated with severe familial obesity disrupts receptor function through multiple molecular mechanisms Hum. Mol. Genet. 12 2003 561 574
33. D.L. Zoran Obesity in dogs and cats: a metabolic and endocrine disorder Vet. Clin. North Am. Small Anim. Pract. 40 2010 221 239