-
1
-
-
79951962147
-
CREB and the CRTC co-activators: sensors for hormonal and metabolic signals
-
Altarejos J.Y., Montminy M. CREB and the CRTC co-activators: sensors for hormonal and metabolic signals. Nat. Rev. Mol. Cell Biol. 2011, 12:141-151.
-
(2011)
Nat. Rev. Mol. Cell Biol.
, vol.12
, pp. 141-151
-
-
Altarejos, J.Y.1
Montminy, M.2
-
2
-
-
84863267488
-
Direct leptin action on POMC neurons regulates glucose homeostasis and hepatic insulin sensitivity in mice
-
Berglund E.D., Vianna C.R., Donato J., Kim M.H., Chuang J.C., Lee C.E., Lauzon D.A., Lin P., Brule L.J., Scott M.M., et al. Direct leptin action on POMC neurons regulates glucose homeostasis and hepatic insulin sensitivity in mice. J.Clin. Invest. 2012, 122:1000-1009.
-
(2012)
J.Clin. Invest.
, vol.122
, pp. 1000-1009
-
-
Berglund, E.D.1
Vianna, C.R.2
Donato, J.3
Kim, M.H.4
Chuang, J.C.5
Lee, C.E.6
Lauzon, D.A.7
Lin, P.8
Brule, L.J.9
Scott, M.M.10
-
3
-
-
84890109255
-
Serotonin 2C receptors in pro-opiomelanocortin neurons regulate energy and glucose homeostasis
-
Berglund E.D., Liu C., Sohn J.W., Liu T., Kim M.H., Lee C.E., Vianna C.R., Williams K.W., Xu Y., Elmquist J.K. Serotonin 2C receptors in pro-opiomelanocortin neurons regulate energy and glucose homeostasis. J.Clin. Invest. 2013, 123:5061-5070.
-
(2013)
J.Clin. Invest.
, vol.123
, pp. 5061-5070
-
-
Berglund, E.D.1
Liu, C.2
Sohn, J.W.3
Liu, T.4
Kim, M.H.5
Lee, C.E.6
Vianna, C.R.7
Williams, K.W.8
Xu, Y.9
Elmquist, J.K.10
-
4
-
-
84903381007
-
Melanocortin 4 receptors in autonomic neurons regulate thermogenesis and glycemia
-
Berglund E.D., Liu T., Kong X., Sohn J.W., Vong L., Deng Z., Lee C.E., Lee S., Williams K.W., Olson D.P., et al. Melanocortin 4 receptors in autonomic neurons regulate thermogenesis and glycemia. Nat. Neurosci. 2014, 17:911-913.
-
(2014)
Nat. Neurosci.
, vol.17
, pp. 911-913
-
-
Berglund, E.D.1
Liu, T.2
Kong, X.3
Sohn, J.W.4
Vong, L.5
Deng, Z.6
Lee, C.E.7
Lee, S.8
Williams, K.W.9
Olson, D.P.10
-
5
-
-
84962845347
-
Autonomic regulation of hepatic glucose production
-
Bisschop P.H., Fliers E., Kalsbeek A. Autonomic regulation of hepatic glucose production. Compr. Physiol. 2015, 5:147-165.
-
(2015)
Compr. Physiol.
, vol.5
, pp. 147-165
-
-
Bisschop, P.H.1
Fliers, E.2
Kalsbeek, A.3
-
6
-
-
84879065487
-
Obesity induces hypothalamic endoplasmic reticulum stress and impairs proopiomelanocortin (POMC) post-translational processing
-
Cakir I., Cyr N.E., Perello M., Litvinov B.P., Romero A., Stuart R.C., Nillni E.A. Obesity induces hypothalamic endoplasmic reticulum stress and impairs proopiomelanocortin (POMC) post-translational processing. J.Biol. Chem. 2013, 288:17675-17688.
-
(2013)
J.Biol. Chem.
, vol.288
, pp. 17675-17688
-
-
Cakir, I.1
Cyr, N.E.2
Perello, M.3
Litvinov, B.P.4
Romero, A.5
Stuart, R.C.6
Nillni, E.A.7
-
7
-
-
79952399495
-
Deletion of Lkb1 in pro-opiomelanocortin neurons impairs peripheral glucose homeostasis in mice
-
Claret M., Smith M.A., Knauf C., Al-Qassab H., Woods A., Heslegrave A., Piipari K., Emmanuel J.J., Colom A., Valet P., et al. Deletion of Lkb1 in pro-opiomelanocortin neurons impairs peripheral glucose homeostasis in mice. Diabetes 2011, 60:735-745.
-
(2011)
Diabetes
, vol.60
, pp. 735-745
-
-
Claret, M.1
Smith, M.A.2
Knauf, C.3
Al-Qassab, H.4
Woods, A.5
Heslegrave, A.6
Piipari, K.7
Emmanuel, J.J.8
Colom, A.9
Valet, P.10
-
8
-
-
84907970671
-
Central ceramide-induced hypothalamic lipotoxicity and ER stress regulate energy balance
-
Contreras C., González-García I., Martínez-Sánchez N., Seoane-Collazo P., Jacas J., Morgan D.A., Serra D., Gallego R., Gonzalez F., Casals N., et al. Central ceramide-induced hypothalamic lipotoxicity and ER stress regulate energy balance. Cell Rep. 2014, 9:366-377.
-
(2014)
Cell Rep.
, vol.9
, pp. 366-377
-
-
Contreras, C.1
González-García, I.2
Martínez-Sánchez, N.3
Seoane-Collazo, P.4
Jacas, J.5
Morgan, D.A.6
Serra, D.7
Gallego, R.8
Gonzalez, F.9
Casals, N.10
-
9
-
-
57349100367
-
Mitofusin 2 tethers endoplasmic reticulum to mitochondria
-
de Brito O.M., Scorrano L. Mitofusin 2 tethers endoplasmic reticulum to mitochondria. Nature 2008, 456:605-610.
-
(2008)
Nature
, vol.456
, pp. 605-610
-
-
de Brito, O.M.1
Scorrano, L.2
-
10
-
-
0024507794
-
Fasting hyperglycemia in non-insulin-dependent diabetes mellitus: contributions of excessive hepatic glucose production and impaired tissue glucose uptake
-
DeFronzo R.A., Ferrannini E., Simonson D.C. Fasting hyperglycemia in non-insulin-dependent diabetes mellitus: contributions of excessive hepatic glucose production and impaired tissue glucose uptake. Metabolism 1989, 38:387-395.
-
(1989)
Metabolism
, vol.38
, pp. 387-395
-
-
DeFronzo, R.A.1
Ferrannini, E.2
Simonson, D.C.3
-
11
-
-
0022558913
-
Inhibition of hepatic gluconeogenesis by the Rp-diastereomer of adenosine cyclic 3',5'-phosphorothioate
-
Dragland-Meserve C.J., Olivieri M.C., Botelho L.H. Inhibition of hepatic gluconeogenesis by the Rp-diastereomer of adenosine cyclic 3',5'-phosphorothioate. Biochem. J. 1986, 237:463-468.
-
(1986)
Biochem. J.
, vol.237
, pp. 463-468
-
-
Dragland-Meserve, C.J.1
Olivieri, M.C.2
Botelho, L.H.3
-
12
-
-
70449927254
-
Prevention of hepatic steatosis and hepatic insulin resistance by knockdown of cAMP response element-binding protein
-
Erion D.M., Ignatova I.D., Yonemitsu S., Nagai Y., Chatterjee P., Weismann D., Hsiao J.J., Zhang D., Iwasaki T., Stark R., et al. Prevention of hepatic steatosis and hepatic insulin resistance by knockdown of cAMP response element-binding protein. Cell Metab. 2009, 10:499-506.
-
(2009)
Cell Metab.
, vol.10
, pp. 499-506
-
-
Erion, D.M.1
Ignatova, I.D.2
Yonemitsu, S.3
Nagai, Y.4
Chatterjee, P.5
Weismann, D.6
Hsiao, J.J.7
Zhang, D.8
Iwasaki, T.9
Stark, R.10
-
13
-
-
84871442771
-
Wired on sugar: the role of the CNS in the regulation of glucose homeostasis
-
Grayson B.E., Seeley R.J., Sandoval D.A. Wired on sugar: the role of the CNS in the regulation of glucose homeostasis. Nat. Rev. Neurosci. 2013, 14:24-37.
-
(2013)
Nat. Rev. Neurosci.
, vol.14
, pp. 24-37
-
-
Grayson, B.E.1
Seeley, R.J.2
Sandoval, D.A.3
-
14
-
-
0035855905
-
CREB regulates hepatic gluconeogenesis through the coactivator PGC-1
-
Herzig S., Long F., Jhala U.S., Hedrick S., Quinn R., Bauer A., Rudolph D., Schutz G., Yoon C., Puigserver P., et al. CREB regulates hepatic gluconeogenesis through the coactivator PGC-1. Nature 2001, 413:179-183.
-
(2001)
Nature
, vol.413
, pp. 179-183
-
-
Herzig, S.1
Long, F.2
Jhala, U.S.3
Hedrick, S.4
Quinn, R.5
Bauer, A.6
Rudolph, D.7
Schutz, G.8
Yoon, C.9
Puigserver, P.10
-
15
-
-
0344010662
-
CREB controls hepatic lipid metabolism through nuclear hormone receptor PPAR-gamma
-
Herzig S., Hedrick S., Morantte I., Koo S.H., Galimi F., Montminy M. CREB controls hepatic lipid metabolism through nuclear hormone receptor PPAR-gamma. Nature 2003, 426:190-193.
-
(2003)
Nature
, vol.426
, pp. 190-193
-
-
Herzig, S.1
Hedrick, S.2
Morantte, I.3
Koo, S.H.4
Galimi, F.5
Montminy, M.6
-
16
-
-
56749112559
-
Endoplasmic reticulum stress induces leptin resistance
-
Hosoi T., Sasaki M., Miyahara T., Hashimoto C., Matsuo S., Yoshii M., Ozawa K. Endoplasmic reticulum stress induces leptin resistance. Mol. Pharmacol. 2008, 74:1610-1619.
-
(2008)
Mol. Pharmacol.
, vol.74
, pp. 1610-1619
-
-
Hosoi, T.1
Sasaki, M.2
Miyahara, T.3
Hashimoto, C.4
Matsuo, S.5
Yoshii, M.6
Ozawa, K.7
-
17
-
-
80053406579
-
Inflammation is necessary for long-term but not short-term high-fat diet-induced insulin resistance
-
Lee Y.S., Li P., Huh J.Y., Hwang I.J., Lu M., Kim J.I., Ham M., Talukdar S., Chen A., Lu W.J., et al. Inflammation is necessary for long-term but not short-term high-fat diet-induced insulin resistance. Diabetes 2011, 60:2474-2483.
-
(2011)
Diabetes
, vol.60
, pp. 2474-2483
-
-
Lee, Y.S.1
Li, P.2
Huh, J.Y.3
Hwang, I.J.4
Lu, M.5
Kim, J.I.6
Ham, M.7
Talukdar, S.8
Chen, A.9
Lu, W.J.10
-
18
-
-
84901194910
-
The transcription factor CREB has no non-redundant functions in hepatic glucose metabolism in mice
-
Lee D., Le Lay J., Kaestner K.H. The transcription factor CREB has no non-redundant functions in hepatic glucose metabolism in mice. Diabetologia 2014, 57:1242-1248.
-
(2014)
Diabetologia
, vol.57
, pp. 1242-1248
-
-
Lee, D.1
Le Lay, J.2
Kaestner, K.H.3
-
19
-
-
0026488079
-
Increased rate of gluconeogenesis in type II diabetes mellitus. A 13C nuclear magnetic resonance study
-
Magnusson I., Rothman D.L., Katz L.D., Shulman R.G., Shulman G.I. Increased rate of gluconeogenesis in type II diabetes mellitus. A 13C nuclear magnetic resonance study. J.Clin. Invest. 1992, 90:1323-1327.
-
(1992)
J.Clin. Invest.
, vol.90
, pp. 1323-1327
-
-
Magnusson, I.1
Rothman, D.L.2
Katz, L.D.3
Shulman, R.G.4
Shulman, G.I.5
-
20
-
-
84883271527
-
Mfn2 modulates the UPR and mitochondrial function via repression of PERK
-
Muñoz J.P., Ivanova S., Sánchez-Wandelmer J., Martínez-Cristóbal P., Noguera E., Sancho A., Díaz-Ramos A., Hernández-Alvarez M.I., Sebastián D., Mauvezin C., et al. Mfn2 modulates the UPR and mitochondrial function via repression of PERK. EMBO J. 2013, 32:2348-2361.
-
(2013)
EMBO J.
, vol.32
, pp. 2348-2361
-
-
Muñoz, J.P.1
Ivanova, S.2
Sánchez-Wandelmer, J.3
Martínez-Cristóbal, P.4
Noguera, E.5
Sancho, A.6
Díaz-Ramos, A.7
Hernández-Alvarez, M.I.8
Sebastián, D.9
Mauvezin, C.10
-
21
-
-
84862009457
-
Loss of mitofusin 2 promotes endoplasmic reticulum stress
-
Ngoh G.A., Papanicolaou K.N., Walsh K. Loss of mitofusin 2 promotes endoplasmic reticulum stress. J.Biol. Chem. 2012, 287:20321-20332.
-
(2012)
J.Biol. Chem.
, vol.287
, pp. 20321-20332
-
-
Ngoh, G.A.1
Papanicolaou, K.N.2
Walsh, K.3
-
22
-
-
5644231992
-
Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes
-
Ozcan U., Cao Q., Yilmaz E., Lee A.H., Iwakoshi N.N., Ozdelen E., Tuncman G., Görgün C., Glimcher L.H., Hotamisligil G.S. Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science 2004, 306:457-461.
-
(2004)
Science
, vol.306
, pp. 457-461
-
-
Ozcan, U.1
Cao, Q.2
Yilmaz, E.3
Lee, A.H.4
Iwakoshi, N.N.5
Ozdelen, E.6
Tuncman, G.7
Görgün, C.8
Glimcher, L.H.9
Hotamisligil, G.S.10
-
23
-
-
33748069813
-
Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes
-
Ozcan U., Yilmaz E., Ozcan L., Furuhashi M., Vaillancourt E., Smith R.O., Görgün C.Z., Hotamisligil G.S. Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes. Science 2006, 313:1137-1140.
-
(2006)
Science
, vol.313
, pp. 1137-1140
-
-
Ozcan, U.1
Yilmaz, E.2
Ozcan, L.3
Furuhashi, M.4
Vaillancourt, E.5
Smith, R.O.6
Görgün, C.Z.7
Hotamisligil, G.S.8
-
24
-
-
57849115277
-
Endoplasmic reticulum stress plays a central role in development of leptin resistance
-
Ozcan L., Ergin A.S., Lu A., Chung J., Sarkar S., Nie D., Myers M.G., Ozcan U. Endoplasmic reticulum stress plays a central role in development of leptin resistance. Cell Metab. 2009, 9:35-51.
-
(2009)
Cell Metab.
, vol.9
, pp. 35-51
-
-
Ozcan, L.1
Ergin, A.S.2
Lu, A.3
Chung, J.4
Sarkar, S.5
Nie, D.6
Myers, M.G.7
Ozcan, U.8
-
25
-
-
79952595599
-
Neural dysregulation of peripheral insulin action and blood pressure by brain endoplasmic reticulum stress
-
Purkayastha S., Zhang H., Zhang G., Ahmed Z., Wang Y., Cai D. Neural dysregulation of peripheral insulin action and blood pressure by brain endoplasmic reticulum stress. Proc. Natl. Acad. Sci. USA 2011, 108:2939-2944.
-
(2011)
Proc. Natl. Acad. Sci. USA
, vol.108
, pp. 2939-2944
-
-
Purkayastha, S.1
Zhang, H.2
Zhang, G.3
Ahmed, Z.4
Wang, Y.5
Cai, D.6
-
26
-
-
79551555006
-
Melanocortin-4 receptors expressed by cholinergic neurons regulate energy balance and glucose homeostasis
-
Rossi J., Balthasar N., Olson D., Scott M., Berglund E., Lee C.E., Choi M.J., Lauzon D., Lowell B.B., Elmquist J.K. Melanocortin-4 receptors expressed by cholinergic neurons regulate energy balance and glucose homeostasis. Cell Metab. 2011, 13:195-204.
-
(2011)
Cell Metab.
, vol.13
, pp. 195-204
-
-
Rossi, J.1
Balthasar, N.2
Olson, D.3
Scott, M.4
Berglund, E.5
Lee, C.E.6
Choi, M.J.7
Lauzon, D.8
Lowell, B.B.9
Elmquist, J.K.10
-
27
-
-
84884823792
-
Mitofusin 2 in POMC neurons connects ER stress with leptin resistance and energy imbalance
-
Schneeberger M., Dietrich M.O., Sebastián D., Imbernón M., Castaño C., Garcia A., Esteban Y., Gonzalez-Franquesa A., Rodríguez I.C., Bortolozzi A., et al. Mitofusin 2 in POMC neurons connects ER stress with leptin resistance and energy imbalance. Cell 2013, 155:172-187.
-
(2013)
Cell
, vol.155
, pp. 172-187
-
-
Schneeberger, M.1
Dietrich, M.O.2
Sebastián, D.3
Imbernón, M.4
Castaño, C.5
Garcia, A.6
Esteban, Y.7
Gonzalez-Franquesa, A.8
Rodríguez, I.C.9
Bortolozzi, A.10
-
28
-
-
84893137029
-
Hypothalamic and brainstem neuronal circuits controlling homeostatic energy balance
-
Schneeberger M., Gomis R., Claret M. Hypothalamic and brainstem neuronal circuits controlling homeostatic energy balance. J.Endocrinol. 2014, 220:T25-T46.
-
(2014)
J.Endocrinol.
, vol.220
, pp. T25-T46
-
-
Schneeberger, M.1
Gomis, R.2
Claret, M.3
-
29
-
-
84859448265
-
Mitofusin 2 (Mfn2) links mitochondrial and endoplasmic reticulum function with insulin signaling and is essential for normal glucose homeostasis
-
Sebastián D., Hernández-Alvarez M.I., Segalés J., Sorianello E., Muñoz J.P., Sala D., Waget A., Liesa M., Paz J.C., Gopalacharyulu P., et al. Mitofusin 2 (Mfn2) links mitochondrial and endoplasmic reticulum function with insulin signaling and is essential for normal glucose homeostasis. Proc. Natl. Acad. Sci. USA 2012, 109:5523-5528.
-
(2012)
Proc. Natl. Acad. Sci. USA
, vol.109
, pp. 5523-5528
-
-
Sebastián, D.1
Hernández-Alvarez, M.I.2
Segalés, J.3
Sorianello, E.4
Muñoz, J.P.5
Sala, D.6
Waget, A.7
Liesa, M.8
Paz, J.C.9
Gopalacharyulu, P.10
-
30
-
-
84879861815
-
Central GLP-2 enhances hepatic insulin sensitivity via activating PI3K signaling in POMC neurons
-
Shi X., Zhou F., Li X., Chang B., Li D., Wang Y., Tong Q., Xu Y., Fukuda M., Zhao J.J., et al. Central GLP-2 enhances hepatic insulin sensitivity via activating PI3K signaling in POMC neurons. Cell Metab. 2013, 18:86-98.
-
(2013)
Cell Metab.
, vol.18
, pp. 86-98
-
-
Shi, X.1
Zhou, F.2
Li, X.3
Chang, B.4
Li, D.5
Wang, Y.6
Tong, Q.7
Xu, Y.8
Fukuda, M.9
Zhao, J.J.10
-
31
-
-
52449086180
-
Intracerebroventricular administration of neuropeptide Y induces hepatic insulin resistance via sympathetic innervation
-
van den Hoek A.M., van Heijningen C., Schröder-van der Elst J.P., Ouwens D.M., Havekes L.M., Romijn J.A., Kalsbeek A., Pijl H. Intracerebroventricular administration of neuropeptide Y induces hepatic insulin resistance via sympathetic innervation. Diabetes 2008, 57:2304-2310.
-
(2008)
Diabetes
, vol.57
, pp. 2304-2310
-
-
van den Hoek, A.M.1
van Heijningen, C.2
Schröder-van der Elst, J.P.3
Ouwens, D.M.4
Havekes, L.M.5
Romijn, J.A.6
Kalsbeek, A.7
Pijl, H.8
-
32
-
-
0035654626
-
Overfeeding rapidly induces leptin and insulin resistance
-
Wang J., Obici S., Morgan K., Barzilai N., Feng Z., Rossetti L. Overfeeding rapidly induces leptin and insulin resistance. Diabetes 2001, 50:2786-2791.
-
(2001)
Diabetes
, vol.50
, pp. 2786-2791
-
-
Wang, J.1
Obici, S.2
Morgan, K.3
Barzilai, N.4
Feng, Z.5
Rossetti, L.6
-
33
-
-
84880981676
-
Adipose tissue inflammation contributes to short-term high-fat diet-induced hepatic insulin resistance
-
Wiedemann M.S., Wueest S., Item F., Schoenle E.J., Konrad D. Adipose tissue inflammation contributes to short-term high-fat diet-induced hepatic insulin resistance. Am. J. Physiol. Endocrinol. Metab. 2013, 305:E388-E395.
-
(2013)
Am. J. Physiol. Endocrinol. Metab.
, vol.305
, pp. E388-E395
-
-
Wiedemann, M.S.1
Wueest, S.2
Item, F.3
Schoenle, E.J.4
Konrad, D.5
-
34
-
-
84913530022
-
Xbp1s in Pomc neurons connectsER stress with energy balance and glucose homeostasis
-
Williams K.W., Liu T., Kong X., Fukuda M., Deng Y., Berglund E.D., Deng Z., Gao Y., Liu T., Sohn J.W., et al. Xbp1s in Pomc neurons connectsER stress with energy balance and glucose homeostasis. Cell Metab. 2014, 20:471-482.
-
(2014)
Cell Metab.
, vol.20
, pp. 471-482
-
-
Williams, K.W.1
Liu, T.2
Kong, X.3
Fukuda, M.4
Deng, Y.5
Berglund, E.D.6
Deng, Z.7
Gao, Y.8
Liu, T.9
Sohn, J.W.10
-
35
-
-
70349507353
-
Central administration of an endoplasmic reticulum stress inducer inhibits the anorexigenic effects of leptin and insulin
-
Won J.C., Jang P.G., Namkoong C., Koh E.H., Kim S.K., Park J.Y., Lee K.U., Kim M.S. Central administration of an endoplasmic reticulum stress inducer inhibits the anorexigenic effects of leptin and insulin. Obesity (Silver Spring) 2009, 17:1861-1865.
-
(2009)
Obesity (Silver Spring)
, vol.17
, pp. 1861-1865
-
-
Won, J.C.1
Jang, P.G.2
Namkoong, C.3
Koh, E.H.4
Kim, S.K.5
Park, J.Y.6
Lee, K.U.7
Kim, M.S.8
-
36
-
-
78650191226
-
5-HT2CRs expressed by pro-opiomelanocortin neurons regulate insulin sensitivity in liver
-
Xu Y., Berglund E.D., Sohn J.W., Holland W.L., Chuang J.C., Fukuda M., Rossi J., Williams K.W., Jones J.E., Zigman J.M., et al. 5-HT2CRs expressed by pro-opiomelanocortin neurons regulate insulin sensitivity in liver. Nat. Neurosci. 2010, 13:1457-1459.
-
(2010)
Nat. Neurosci.
, vol.13
, pp. 1457-1459
-
-
Xu, Y.1
Berglund, E.D.2
Sohn, J.W.3
Holland, W.L.4
Chuang, J.C.5
Fukuda, M.6
Rossi, J.7
Williams, K.W.8
Jones, J.E.9
Zigman, J.M.10
-
37
-
-
52949096557
-
Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity
-
Zhang X., Zhang G., Zhang H., Karin M., Bai H., Cai D. Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity. Cell 2008, 135:61-73.
-
(2008)
Cell
, vol.135
, pp. 61-73
-
-
Zhang, X.1
Zhang, G.2
Zhang, H.3
Karin, M.4
Bai, H.5
Cai, D.6
|