The E3 ligase synoviolin controls body weight and mitochondrial biogenesis through negative regulation of PGC-1β

EMBO Journal

Volumn 34, Issue 8, 2015, Pages 1042-1055

  Fujita, Hidetoshi ^a   Yagishita, Naoko ^b   Aratani, Satoko ^a   Saito Fujita, Tomoko ^c   Morota, Saori ^a   Yamano, Yoshihisa ^b   Hansson, Magnus J ^d   Inazu, Masato ^a   Kokuba, Hiroko ^a   Sudo, Katsuko ^a   Sato, Eiichi ^a,e   Kawahara, Ko Ichi ^f   Nakajima, Fukami ^a   Hasegawa, Daisuke ^b   Higuchi, Itsuro ^g   Sato, Tomoo ^b   Araya, Natsumi ^b   Usui, Chie ^h   Nishioka, Kenya ⁱ   Nakatani, Yu ^a   Maruyama, Ikuro ^j   Usui, Masahiko ^a   Hara, Naomi ^a   Uchino, Hiroyuki ^a   Elmer, Eskil ^d   Nishioka, Kusuki ^a   Nakajima, Toshihiro ^a,b,e,f,k   more..

^a TOKYO MEDICAL UNIVERSITY   (Japan)

^b ST MARIANNA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

^d LUND UNIVERSITY   (Sweden)

^e TOKYO MEDICAL UNIVERSITY HOSPITAL   (Japan)

^f OSAKA INSTITUTE OF TECHNOLOGY   (Japan)

^g KAGOSHIMA UNIVERSITY   (Japan)

^h JUNTENDO UNIVERSITY NERIMA HOSPITAL   (Japan)

ⁱ JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^j KAGOSHIMA UNIVERSITY   (Japan)

^k Bayside Misato Medical Center Kochi   (Japan)

more..

Author keywords

endoplasmic reticulum; mitochondria; obesity; PGC 1 ; synoviolin

Indexed keywords

LIGASE INHIBITOR; LS 102; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1BETA; SYNOVIOLIN; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; HRD1 PROTEIN, MOUSE; PPARGC1A PROTEIN, MOUSE; TRANSCRIPTION FACTOR; UBIQUITIN PROTEIN LIGASE;

3T3 CELL LINE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOGENESIS; BODY WEIGHT; CONTROLLED STUDY; DRUG EFFECT; DRUG TARGETING; ENERGY EXPENDITURE; ENZYME INHIBITION; GENE; GENE INACTIVATION; GENE OVEREXPRESSION; HEK293 CELL LINE; MITOCHONDRIAL RESPIRATION; MITOCHONDRION; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; REGULATORY MECHANISM; SYVN1 GENE; WEIGHT REDUCTION; WHITE ADIPOSE TISSUE; ANIMAL; C57BL MOUSE; CELL CULTURE; DOWN REGULATION; GENETICS; HUMAN; KNOCKOUT MOUSE; METABOLISM; MOUSE MUTANT; PHYSIOLOGY; UBIQUITINATION;

ANIMALIA; MUS;

3T3-L1 CELLS; ANIMALS; BODY WEIGHT; CELLS, CULTURED; DOWN-REGULATION; HEK293 CELLS; HUMANS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, OBESE; MITOCHONDRIA; OBESITY; TRANSCRIPTION FACTORS; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

EID: 84927698900     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.15252/embj.201489897     Document Type: Article

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