Partially Redundant Enhancers Cooperatively Maintain Mammalian Pomc Expression Above a Critical Functional Threshold

PLoS Genetics

Volumn 11, Issue 2, 2015, Pages 1-21

  Lam, Daniel D ^a   de Souza, Flavio S J ^b,c   Nasif, Sofia ^b   Yamashita, Miho ^a   López Leal, Rodrigo ^d   Otero Corchon, Veronica ^a   Meece, Kana ^e   Sampath, Harini ^f   Mercer, Aaron J ^a   Wardlaw, Sharon L ^e   Rubinstein, Marcelo ^a,b,c   Low, Malcolm J ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b INSTITUTO DE INVESTIGACIONES EN INGENIERÍA GENÉTICA Y BIOLOGÍA MOLECULAR   (Argentina)

^c UNIVERSIDAD DE BUENOS AIRES   (Argentina)

^d CENTRO DE ESTUDIOS CIENTÍFICOS CECS   (Chile)

^e Columbia University College of Physicians and Surgeons ^*  (United States)

^f OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROOPIOMELANOCORTIN;

ADULT; ADULTHOOD; ANIMAL CELL; ARTICLE; BRAIN CELL; CONTROLLED STUDY; EMBRYO; EMBRYO DEVELOPMENT; ENHANCER REGION; GENE; GENE DELETION; GENE EXPRESSION; GENE IDENTIFICATION; GENE MUTATION; GENE SEQUENCE; GENETIC CONSERVATION; GENETIC REGULATION; GENETIC TRANSCRIPTION; HYPOTHALAMUS; MOLECULAR INTERACTION; MOUSE; NONHUMAN; OBESITY; PHENOTYPE; POMC GENE; ANIMAL; BIOSYNTHESIS; DEFICIENCY; FEMALE; GENE EXPRESSION REGULATION; GENETICS; MAMMAL; METABOLISM; MOLECULAR EVOLUTION; NERVE CELL; NUCLEOTIDE SEQUENCE; PHYLOGENY; PREGNANCY; REGULATORY SEQUENCE;

MAMMALIA; MUS; VERTEBRATA;

ANIMALS; CONSERVED SEQUENCE; EMBRYONIC DEVELOPMENT; ENHANCER ELEMENTS, GENETIC; EVOLUTION, MOLECULAR; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; MAMMALS; MICE; NEURONS; PHYLOGENY; PREGNANCY; PRO-OPIOMELANOCORTIN; REGULATORY SEQUENCES, NUCLEIC ACID;

EID: 84924415717     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1004935     Document Type: Article

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