Nicotinamide Improves Aspects of Healthspan, but Not Lifespan, in Mice

Cell Metabolism

Volumn 27, Issue 3, 2018, Pages 667-676.e4

  Mitchell, Sarah J ^a   Bernier, Michel ^a   Aon, Miguel A ^a   Cortassa, Sonia ^a   Kim, Eun Young ^a,b   Fang, Evandro F ^a   Palacios, Hector H ^a   Ali, Ahmed ^a   Navas Enamorado, Ignacio ^a   Di Francesco, Andrea ^a   Kaiser, Tamzin A ^a   Waltz, Tyler B ^a   Zhang, Ning ^c   Ellis, James L ^d   Elliott, Peter J ^d   Frederick, David W ^e   Bohr, Vilhelm A ^a   Schmidt, Mark S ^f   Brenner, Charles ^f   Sinclair, David A ^g   Sauve, Anthony A ^c   Baur, Joseph A ^e   de Cabo, Rafael ^a   more..

^a NATIONAL INSTITUTE ON AGING   (United States)

^b Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^c WEILL CORNELL MEDICAL COLLEGE   (United States)

^d GLAXOSMITHKLINE   (United States)

^e UNIVERSITY OF PENNSYLVANIA   (United States)

^f UNIVERSITY OF IOWA   (United States)

^g HARVARD MEDICAL SCHOOL   (United States)

Author keywords

aging; calorie restriction mimetics; dietary interventions; geroscience; high fat diet; NAD; NAMPT; nicotinamide; sirtuin

Indexed keywords

6 PHOSPHOFRUCTOKINASE; ACETYL COENZYME A; ADENOSINE TRIPHOSPHATE; CITRATE SYNTHASE; CITRIC ACID; FRUCTOSE; FRUCTOSE 1 PHOSPHATE; GLUCOSE; GLUCOSE 1 PHOSPHATE; GLUCOSE 6 PHOSPHATE; GLYCERALDEHYDE 3 PHOSPHATE; GLYCEROPHOSPHATE; GLYCOGEN; LACTIC ACID; LIPID; NICOTINAMIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; NICOTINAMIDE NUCLEOTIDE; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE; OXYGEN; PALMITIC ACID; PENTOSE PHOSPHATE; POLYOL; PYRUVATE CARBOXYLASE; PYRUVATE DEHYDROGENASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SIRTUIN 1; SORBITOL; TRICARBOXYLIC ACID; SIRT1 PROTEIN, MOUSE;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CITRIC ACID CYCLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; FATTY ACID OXIDATION; GENE EXPRESSION; GLUCOSE HOMEOSTASIS; GLUCOSE TOLERANCE; GLYCOLYSIS; HEALTH; HEALTHSPAN; HEP-G2 CELL LINE; HIGH-FAT DIET-INDUCED STEATOHEPATITIS; HOMEOSTASIS MODEL ASSESSMENT; HUMAN; HUMAN CELL; INFLAMMATION; LIFESPAN; LIPID DIET; LIVER; LIVER PROTECTION; MALE; METABOLIC FLUX ANALYSIS; METABOLOME; METABOLOMICS; MOUSE; NONHUMAN; OXIDATIVE STRESS; OXYGEN CONSUMPTION; PENTOSE PHOSPHATE CYCLE; PH; PRIORITY JOURNAL; SALVAGE THERAPY; SIGNAL TRANSDUCTION; SUPPLEMENTATION; ANIMAL; C57BL MOUSE; DIETARY SUPPLEMENT; DISEASE MODEL; DRUG EFFECT; FATTY LIVER; HEALTHY AGING; LONGEVITY; METABOLISM;

ANIMALS; DIET, HIGH-FAT; DIETARY SUPPLEMENTS; DISEASE MODELS, ANIMAL; FATTY LIVER; HEALTHY AGING; INFLAMMATION; LIVER; LONGEVITY; MICE, INBRED C57BL; NAD; NIACINAMIDE; OXIDATIVE STRESS; SIRTUIN 1;

EID: 85042758873     PISSN: 15504131     EISSN: 19327420     Source Type: Journal    
DOI: 10.1016/j.cmet.2018.02.001     Document Type: Article

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