Long-term treatment with nicotinamide induces glucose intolerance and skeletal muscle lipotoxicity in normal chow-fed mice: compared to diet-induced obesity

Journal of Nutritional Biochemistry

Volumn 36, Issue , 2016, Pages 31-41

  Qi, Zhengtang ^a,b   Xia, Jie ^a,b   Xue, Xiangli ^a,b   He, Qiang ^a,b   Ji, Liu ^a,b   Ding, Shuzhe ^a,b  

^a East China Normal University   (China)

^b EAST CHINA NORMAL UNIVERSITY   (China)

Author keywords

Insulin resistance; Lipid accumulation; Mitochondrial; Mitophagy; Nicotinamide (NAM); Sirtuin 1; Skeletal muscle

Indexed keywords

FATTY ACID; LIPID; NICOTINAMIDE; RESVERATROL; ANTIOXIDANT; HISTONE DEACETYLASE INHIBITOR; MUSCLE PROTEIN; SIRT1 PROTEIN, MOUSE; SIRTUIN 1; STILBENE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPHAGY; BECLIN 1 GENE; BNIP3 GENE; CONTROLLED STUDY; CTSL GENE; DIET; DIET INDUCED OBESITY; ENERGY YIELD; FOXO3 GENE; GENE; GLUCOSE HOMEOSTASIS; GLUCOSE INTOLERANCE; INSULIN RESISTANCE; INSULIN SENSITIVITY; LC 3B GENE; LIPID DIET; LIPID METABOLISM; LIPID STORAGE; LIPOTOXICITY; LONG TERM CARE; MALE; MITOCHONDRIAL RESPIRATION; MITOPHAGY; MOUSE; NIX GENE; NONHUMAN; P62 GENE; PARK2 GENE; PINK1 GENE; SKELETAL MUSCLE; SKELETAL MUSCLE LIPOTOXICITY; ADVERSE EFFECTS; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; COMPARATIVE STUDY; DIETARY SUPPLEMENT; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; OBESITY; TIME FACTOR;

ANIMALS; ANTIOXIDANTS; AUTOPHAGY; DIET, HIGH-FAT; DIETARY SUPPLEMENTS; GENE EXPRESSION REGULATION; GLUCOSE INTOLERANCE; HISTONE DEACETYLASE INHIBITORS; INSULIN RESISTANCE; LIPID METABOLISM; MALE; MICE, INBRED C57BL; MITOCHONDRIAL DEGRADATION; MUSCLE PROTEINS; MUSCLE, SKELETAL; NIACINAMIDE; OBESITY; SIRTUIN 1; STILBENES; TIME FACTORS;

EID: 84983756911     PISSN: 09552863     EISSN: 18734847     Source Type: Journal    
DOI: 10.1016/j.jnutbio.2016.07.005     Document Type: Article

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