메뉴 건너뛰기




Volumn 130, Issue , 2018, Pages 322-330

Cellular senescence as a therapeutic target to improve renal transplantation outcome

Author keywords

Anti senescence compounds; FOXO4 DRI; Ischemia reperfusion injury; Navitoclax; Renal transplantation; Senescence

Indexed keywords

ALVESPIMYCIN; DASATINIB; FORKHEAD BOX O4 DEXTRO RETROINVERSO PEPTIDE; FORKHEAD TRANSCRIPTION FACTOR; GELDANAMYCIN; NAVITOCLAX; QUERCETIN; SENESCENCE ASSOCIATED SECRETORY PHENOTYPE; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

EID: 85042361360     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2018.02.015     Document Type: Review
Times cited : (26)

References (116)
  • 1
    • 85028595784 scopus 로고    scopus 로고
    • Determinants of health care costs in the senior elderly: age, comorbidity, impairment, or proximity to death?
    • Hazra, N.C., Rudisill, C., Gulliford, M.C., Determinants of health care costs in the senior elderly: age, comorbidity, impairment, or proximity to death?. Eur. J. Heal. Econ., 2017, 1–12, 10.1007/s10198-017-0926-2.
    • (2017) Eur. J. Heal. Econ. , pp. 1-12
    • Hazra, N.C.1    Rudisill, C.2    Gulliford, M.C.3
  • 2
    • 85013427426 scopus 로고    scopus 로고
    • Future life expectancy in 35 industrialised countries: projections with a Bayesian model ensemble
    • Kontis, V., et al. Future life expectancy in 35 industrialised countries: projections with a Bayesian model ensemble. Lancet (Lond. Engl.) 389 (2017), 1323–1335.
    • (2017) Lancet (Lond. Engl.) , vol.389 , pp. 1323-1335
    • Kontis, V.1
  • 4
    • 80052340001 scopus 로고    scopus 로고
    • Aging with multimorbidity: a systematic review of the literature
    • Marengoni, A., et al. Aging with multimorbidity: a systematic review of the literature. Ageing Res. Rev. 10 (2011), 430–439.
    • (2011) Ageing Res. Rev. , vol.10 , pp. 430-439
    • Marengoni, A.1
  • 5
    • 84900431386 scopus 로고    scopus 로고
    • Multimorbidity of chronic diseases and health care utilization in general practice
    • van Oostrom, S.H., et al. Multimorbidity of chronic diseases and health care utilization in general practice. BMC Fam. Pract., 15, 2014, 61.
    • (2014) BMC Fam. Pract. , vol.15 , pp. 61
    • van Oostrom, S.H.1
  • 6
    • 84978128484 scopus 로고    scopus 로고
    • Global prevalence of chronic kidney disease – a systematic review and meta-analysis
    • Hill, N.R., et al. Global prevalence of chronic kidney disease – a systematic review and meta-analysis. PLoS One, 11, 2016, e0158765.
    • (2016) PLoS One , vol.11 , pp. e0158765
    • Hill, N.R.1
  • 8
    • 77953716953 scopus 로고    scopus 로고
    • Chronic kidney disease and end-stage renal disease in the elderly population: current prevalence, future projections, and clinical significance
    • Stevens, L.A., Viswanathan, G., Weiner, D.E., Chronic kidney disease and end-stage renal disease in the elderly population: current prevalence, future projections, and clinical significance. Adv. Chronic Kidney Dis. 17 (2010), 293–301.
    • (2010) Adv. Chronic Kidney Dis. , vol.17 , pp. 293-301
    • Stevens, L.A.1    Viswanathan, G.2    Weiner, D.E.3
  • 9
    • 84884689933 scopus 로고    scopus 로고
    • Novel drugs and intervention strategies for the treatment of chronic kidney disease
    • Heerspink, H.L., de Zeeuw, D., Novel drugs and intervention strategies for the treatment of chronic kidney disease. Br. J. Clin. Pharmacol 76:4 (2013), 536–550.
    • (2013) Br. J. Clin. Pharmacol , vol.76 , Issue.4 , pp. 536-550
    • Heerspink, H.L.1    de Zeeuw, D.2
  • 11
    • 84975125113 scopus 로고    scopus 로고
    • Defining end-stage renal disease in clinical trials: a framework for adjudication: table 1
    • Agarwal, R., Defining end-stage renal disease in clinical trials: a framework for adjudication: table 1. Nephrol. Dial. Transplant. 31 (2016), 864–867.
    • (2016) Nephrol. Dial. Transplant. , vol.31 , pp. 864-867
    • Agarwal, R.1
  • 12
    • 84872084618 scopus 로고    scopus 로고
    • Outcomes of kidney transplantation from older living donors
    • Lim, W.H., et al. Outcomes of kidney transplantation from older living donors. Transplant. J. 95 (2013), 106–113.
    • (2013) Transplant. J. , vol.95 , pp. 106-113
    • Lim, W.H.1
  • 13
    • 84902131928 scopus 로고    scopus 로고
    • Mechanisms and consequences of injury and repair in older organ transplants
    • Slegtenhorst, B.R., et al. Mechanisms and consequences of injury and repair in older organ transplants. Transplantation 97 (2014), 1091–1099.
    • (2014) Transplantation , vol.97 , pp. 1091-1099
    • Slegtenhorst, B.R.1
  • 14
    • 84903515063 scopus 로고    scopus 로고
    • Effect of donor–recipient age difference on long-term graft survival in living kidney transplantation
    • Tasaki, M., et al. Effect of donor–recipient age difference on long-term graft survival in living kidney transplantation. Int. Urol. Nephrol. 46 (2014), 1441–1446.
    • (2014) Int. Urol. Nephrol. , vol.46 , pp. 1441-1446
    • Tasaki, M.1
  • 15
    • 84855911567 scopus 로고    scopus 로고
    • Donor age-specific injury and immune responses
    • Oberhuber, R., Ge, X., Tullius, S.G., Donor age-specific injury and immune responses. Am. J. Transplant. 12 (2012), 38–42.
    • (2012) Am. J. Transplant. , vol.12 , pp. 38-42
    • Oberhuber, R.1    Ge, X.2    Tullius, S.G.3
  • 16
    • 84980004968 scopus 로고    scopus 로고
    • Nierentransplantation im alter
    • Kurschat, C., Nierentransplantation im alter. Z. Gerontol. Geriatr. 49 (2016), 488–493.
    • (2016) Z. Gerontol. Geriatr. , vol.49 , pp. 488-493
    • Kurschat, C.1
  • 17
    • 84866000795 scopus 로고    scopus 로고
    • Cellular senescence limits regenerative capacity and allograft survival
    • Braun, H., et al. Cellular senescence limits regenerative capacity and allograft survival. J. Am. Soc. Nephrol. 23 (2012), 1467–1473.
    • (2012) J. Am. Soc. Nephrol. , vol.23 , pp. 1467-1473
    • Braun, H.1
  • 18
    • 20544432681 scopus 로고    scopus 로고
    • Increased expression of senescence-associated cell cycle inhibitor p16/INK4a in deteriorating renal transplants and diseased native kidney
    • Melk, A., Schmidt, B.M.W., Vongwiwatana, A., Rayner, D.C., Halloran, P.F., Increased expression of senescence-associated cell cycle inhibitor p16/INK4a in deteriorating renal transplants and diseased native kidney. Am. J. Transplant. 5 (2005), 1375–1382.
    • (2005) Am. J. Transplant. , vol.5 , pp. 1375-1382
    • Melk, A.1    Schmidt, B.M.W.2    Vongwiwatana, A.3    Rayner, D.C.4    Halloran, P.F.5
  • 19
    • 70349859881 scopus 로고    scopus 로고
    • DNA damage, aging, and cancer
    • Hoeijmakers, J.H.J., DNA damage, aging, and cancer. N. Engl. J. Med. 361 (2009), 1475–1485.
    • (2009) N. Engl. J. Med. , vol.361 , pp. 1475-1485
    • Hoeijmakers, J.H.J.1
  • 20
    • 84904626614 scopus 로고    scopus 로고
    • Cell senescence: role in aging and age-related diseases. Interdiscip
    • Campisi, J., Robert, L., Cell senescence: role in aging and age-related diseases. Interdiscip. Interdiscip. Top. Gerontol. 39 (2014), 45–61.
    • (2014) Interdiscip. Top. Gerontol. , vol.39 , pp. 45-61
    • Campisi, J.1    Robert, L.2
  • 21
    • 84873638532 scopus 로고    scopus 로고
    • Cellular senescence, and cancer
    • Campisi, Aging, J., Cellular senescence, and cancer. Annu. Rev. Physiol. 75 (2013), 685–705.
    • (2013) Annu. Rev. Physiol. , vol.75 , pp. 685-705
    • Campisi1    Aging, J.2
  • 22
    • 84904702784 scopus 로고    scopus 로고
    • Cellular senescence: from physiology to pathology
    • Muñoz-Espín, D., Serrano, M., Cellular senescence: from physiology to pathology. Nat. Rev. Mol. Cell Biol. 15 (2014), 482–496.
    • (2014) Nat. Rev. Mol. Cell Biol. , vol.15 , pp. 482-496
    • Muñoz-Espín, D.1    Serrano, M.2
  • 23
    • 35348996558 scopus 로고    scopus 로고
    • p21Waf1/Cip1/Sdi1 mediates retinoblastoma protein degradation
    • Broude, EV, et al. p21Waf1/Cip1/Sdi1 mediates retinoblastoma protein degradation. Oncogene 26 (2007), 6954–6958.
    • (2007) Oncogene , vol.26 , pp. 6954-6958
    • Broude1    EV2
  • 24
    • 84857504660 scopus 로고    scopus 로고
    • Cellular senescence and tumor suppressor gene p16
    • Rayess, H., Wang, M.B., Srivatsan, E.S., Cellular senescence and tumor suppressor gene p16. Int. J. Cancer 130 (2012), 1715–1725.
    • (2012) Int. J. Cancer , vol.130 , pp. 1715-1725
    • Rayess, H.1    Wang, M.B.2    Srivatsan, E.S.3
  • 25
    • 84901288438 scopus 로고    scopus 로고
    • The role of senescent cells in ageing
    • van Deursen, J.M., The role of senescent cells in ageing. Nature 509 (2014), 439–446.
    • (2014) Nature , vol.509 , pp. 439-446
    • van Deursen, J.M.1
  • 26
    • 84891713034 scopus 로고    scopus 로고
    • Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor
    • Coppé J.-P., et al. Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor. PLoS Biol., 6, 2008, e301.
    • (2008) PLoS Biol. , vol.6 , pp. e301
    • Coppé, J.-P.1
  • 27
    • 77949881221 scopus 로고    scopus 로고
    • The senescence-associated secretory phenotype: the dark side of tumor suppression
    • Coppé J.-P., Desprez, P.-Y., Krtolica, A., Campisi, J., The senescence-associated secretory phenotype: the dark side of tumor suppression. Annu. Rev. Pathol. 5 (2010), 99–118.
    • (2010) Annu. Rev. Pathol. , vol.5 , pp. 99-118
    • Coppé, J.-P.1    Desprez, P.-Y.2    Krtolica, A.3    Campisi, J.4
  • 28
    • 84919480323 scopus 로고    scopus 로고
    • An essential role for senescent cells in optimal wound healing through secretion of PDGF-AA
    • Demaria, M., et al. An essential role for senescent cells in optimal wound healing through secretion of PDGF-AA. Dev. Cell, 31, 2014.
    • (2014) Dev. Cell , vol.31
    • Demaria, M.1
  • 29
    • 84889600900 scopus 로고    scopus 로고
    • Programmed cell senescence during mammalian embryonic development
    • Muñoz-Espín, D., et al. Programmed cell senescence during mammalian embryonic development. Cell 155 (2013), 1104–1118.
    • (2013) Cell , vol.155 , pp. 1104-1118
    • Muñoz-Espín, D.1
  • 30
    • 84890458719 scopus 로고    scopus 로고
    • Immunosurveillance of senescent cells: the bright side of the senescence program
    • Sagiv, A., Krizhanovsky, V., Immunosurveillance of senescent cells: the bright side of the senescence program. Biogerontology 141 (2013), 617–628.
    • (2013) Biogerontology , vol.141 , pp. 617-628
    • Sagiv, A.1    Krizhanovsky, V.2
  • 32
    • 84940069425 scopus 로고    scopus 로고
    • NK cells of kidney transplant recipients display an activated phenotype that is influenced by immunosuppression and pathological staging
    • Hoffmann, U., et al. NK cells of kidney transplant recipients display an activated phenotype that is influenced by immunosuppression and pathological staging. PLoS One, 10, 2015, e0132484.
    • (2015) PLoS One , vol.10 , pp. e0132484
    • Hoffmann, U.1
  • 33
    • 78149428750 scopus 로고    scopus 로고
    • Renal transplant immunosuppression impairs natural killer cell function in vitro and in vivo
    • Morteau, O., et al. Renal transplant immunosuppression impairs natural killer cell function in vitro and in vivo. PLoS One, 5, 2010, e13294.
    • (2010) PLoS One , vol.5 , pp. e13294
    • Morteau, O.1
  • 34
    • 84900988267 scopus 로고    scopus 로고
    • Chronic inflammation (Inflammaging) and its potential contribution to age-associated diseases
    • Franceschi, C., Campisi, J., Chronic inflammation (Inflammaging) and its potential contribution to age-associated diseases. J. Gerontol. Ser. A Biol. Sci. Med. Sci., 69, 2014.
    • (2014) J. Gerontol. Ser. A Biol. Sci. Med. Sci. , vol.69
    • Franceschi, C.1    Campisi, J.2
  • 35
    • 80855128461 scopus 로고    scopus 로고
    • Cellular senescence: a link between cancer and age-related degenerative disease?
    • Campisi, J., Andersen, J.K., Kapahi, P., Melov, S., Cellular senescence: a link between cancer and age-related degenerative disease?. Semin. Cancer Biol. 21 (2011), 354–359.
    • (2011) Semin. Cancer Biol. , vol.21 , pp. 354-359
    • Campisi, J.1    Andersen, J.K.2    Kapahi, P.3    Melov, S.4
  • 36
    • 84949555897 scopus 로고    scopus 로고
    • Cellular senescence in aging and age-related disease: from mechanisms to therapy
    • Childs, B.G., Durik, M., Baker, D.J., van Deursen, J.M., Cellular senescence in aging and age-related disease: from mechanisms to therapy. Nat. Med., 21, 2015.
    • (2015) Nat. Med. , vol.21
    • Childs, B.G.1    Durik, M.2    Baker, D.J.3    van Deursen, J.M.4
  • 38
    • 80555157523 scopus 로고    scopus 로고
    • Cellular pathophysiology of ischemic acute kidney injury
    • Bonventre, J.V., Yang, L., Cellular pathophysiology of ischemic acute kidney injury. J. Clin. Invest. 121 (2011), 4210–4221.
    • (2011) J. Clin. Invest. , vol.121 , pp. 4210-4221
    • Bonventre, J.V.1    Yang, L.2
  • 39
    • 84997501267 scopus 로고    scopus 로고
    • Tissue damage and senescence provide critical signals for cellular reprogramming in vivo
    • Mosteiro, L., et al. Tissue damage and senescence provide critical signals for cellular reprogramming in vivo. Science (80-.), 354, 2016, aaf4445.
    • (2016) Science (80-.) , vol.354 , pp. aaf4445
    • Mosteiro, L.1
  • 40
    • 85007351303 scopus 로고    scopus 로고
    • The fountain of youth by targeting senescent cells?
    • de Keizer, P.L.J., The fountain of youth by targeting senescent cells?. Trends Mol. Med. 23 (2017), 6–17.
    • (2017) Trends Mol. Med. , vol.23 , pp. 6-17
    • de Keizer, P.L.J.1
  • 41
    • 84944720362 scopus 로고    scopus 로고
    • Update on ischemia-reperfusion injury in kidney transplantation: pathogenesis and treatment
    • Salvadori, M., Rosso, G., Bertoni, E., Update on ischemia-reperfusion injury in kidney transplantation: pathogenesis and treatment. World J. Transplant. 5 (2015), 52–67.
    • (2015) World J. Transplant. , vol.5 , pp. 52-67
    • Salvadori, M.1    Rosso, G.2    Bertoni, E.3
  • 42
    • 47349113962 scopus 로고    scopus 로고
    • Markers of cellular senescence in zero hour biopsies predict outcome in renal transplantation
    • Koppelstaetter, C., et al. Markers of cellular senescence in zero hour biopsies predict outcome in renal transplantation. Aging Cell 7 (2008), 491–497.
    • (2008) Aging Cell , vol.7 , pp. 491-497
    • Koppelstaetter, C.1
  • 43
    • 59049099339 scopus 로고    scopus 로고
    • Cellular senescence in pretransplant renal biopsies predicts postoperative organ function
    • McGlynn, L.M., et al. Cellular senescence in pretransplant renal biopsies predicts postoperative organ function. Aging Cell 8 (2009), 45–51.
    • (2009) Aging Cell , vol.8 , pp. 45-51
    • McGlynn, L.M.1
  • 44
    • 58049202919 scopus 로고    scopus 로고
    • Effects of donor age and cell senescence on kidney allograft survival
    • Melk, A., et al. Effects of donor age and cell senescence on kidney allograft survival. Am. J. Transplant. 9 (2008), 114–123.
    • (2008) Am. J. Transplant. , vol.9 , pp. 114-123
    • Melk, A.1
  • 45
    • 3242752786 scopus 로고    scopus 로고
    • Molecular events associated with reactive oxygen species and cell cycle progression in mammalian cells
    • Boonstra, J., Post, J.A., Molecular events associated with reactive oxygen species and cell cycle progression in mammalian cells. Gene 337 (2004), 1–13.
    • (2004) Gene , vol.337 , pp. 1-13
    • Boonstra, J.1    Post, J.A.2
  • 46
    • 84994877104 scopus 로고    scopus 로고
    • A new role for oxidative stress in aging: the accelerated aging phenotype in Sod1-/-mice is correlated to increased cellular senescence
    • Zhang, Y., et al. A new role for oxidative stress in aging: the accelerated aging phenotype in Sod1-/-mice is correlated to increased cellular senescence. Redox Biol. 11 (2017), 30–37.
    • (2017) Redox Biol. , vol.11 , pp. 30-37
    • Zhang, Y.1
  • 47
    • 33846862269 scopus 로고    scopus 로고
    • p21 and mTERT are novel markers for determining different ischemic time periods in renal ischemia-reperfusion injury
    • Hochegger, K., et al. p21 and mTERT are novel markers for determining different ischemic time periods in renal ischemia-reperfusion injury. Am. J. Physiol. Renal Physiol. 292 (2007), F762–F768.
    • (2007) Am. J. Physiol. Renal Physiol. , vol.292 , pp. F762-F768
    • Hochegger, K.1
  • 48
    • 34548796464 scopus 로고    scopus 로고
    • P53-Rb signaling pathway is involved in tubular cell senescence in renal ischemia/reperfusion injury
    • Kailong, L., et al. P53-Rb signaling pathway is involved in tubular cell senescence in renal ischemia/reperfusion injury. Biocell 31 (2007), 213–223.
    • (2007) Biocell , vol.31 , pp. 213-223
    • Kailong, L.1
  • 49
    • 46449122575 scopus 로고    scopus 로고
    • Hypertension induces somatic cellular senescence in rats and humans by induction of cell cycle inhibitor p16INK4a
    • Westhoff, J.H., et al. Hypertension induces somatic cellular senescence in rats and humans by induction of cell cycle inhibitor p16INK4a. Hypertension 52 (2008), 123–129.
    • (2008) Hypertension , vol.52 , pp. 123-129
    • Westhoff, J.H.1
  • 50
    • 79952115737 scopus 로고    scopus 로고
    • Cellular senescence controls fibrosis in wound healing
    • Jun, J.-I., Lau, L.F., Cellular senescence controls fibrosis in wound healing. Aging (Albany NY) 2 (2010), 627–631.
    • (2010) Aging (Albany NY) , vol.2 , pp. 627-631
    • Jun, J.-I.1    Lau, L.F.2
  • 51
    • 84875975382 scopus 로고    scopus 로고
    • Biological responses to PDGF-AA versus PDGF-CC in renal fibroblasts
    • Seikrit, C., et al. Biological responses to PDGF-AA versus PDGF-CC in renal fibroblasts. Nephrol. Dial. Transplant. 28 (2013), 889–900.
    • (2013) Nephrol. Dial. Transplant. , vol.28 , pp. 889-900
    • Seikrit, C.1
  • 53
    • 83455176430 scopus 로고    scopus 로고
    • INK4a deletion results in improved kidney regeneration and decreased capillary rarefaction after ischemia-reperfusion injury
    • Lee, D.H., Wolstein, J.M., Pudasaini, B., Plotkin, M., INK4a deletion results in improved kidney regeneration and decreased capillary rarefaction after ischemia-reperfusion injury. AJP Renal Physiol. 302 (2012), F183–F191.
    • (2012) AJP Renal Physiol. , vol.302 , pp. F183-F191
    • Lee, D.H.1    Wolstein, J.M.2    Pudasaini, B.3    Plotkin, M.4
  • 54
    • 0035176512 scopus 로고    scopus 로고
    • Positive effect of the induction of p21WAF1/CIP1 on the course of ischemic acute renal failure
    • Megyesi, J., Andrade, L., Vieira, J.M., Safirstein, R.L., Price, P.M., Positive effect of the induction of p21WAF1/CIP1 on the course of ischemic acute renal failure. Kidney Int. 60 (2001), 2164–2172.
    • (2001) Kidney Int. , vol.60 , pp. 2164-2172
    • Megyesi, J.1    Andrade, L.2    Vieira, J.M.3    Safirstein, R.L.4    Price, P.M.5
  • 55
    • 84897954551 scopus 로고    scopus 로고
    • The cyclin-dependent kinase inhibitor p21 is essential for the beneficial effects of renal ischemic preconditioning on renal ischemia/reperfusion injury in mice
    • Nishioka, S., et al. The cyclin-dependent kinase inhibitor p21 is essential for the beneficial effects of renal ischemic preconditioning on renal ischemia/reperfusion injury in mice. Kidney Int. 85 (2014), 871–879.
    • (2014) Kidney Int. , vol.85 , pp. 871-879
    • Nishioka, S.1
  • 56
    • 84894046460 scopus 로고    scopus 로고
    • CDK4/6 inhibition induces epithelial cell cycle arrest and ameliorates acute kidney injury
    • DiRocco, D.P., et al. CDK4/6 inhibition induces epithelial cell cycle arrest and ameliorates acute kidney injury. AJP Renal Physiol. 306 (2014), F379–F388.
    • (2014) AJP Renal Physiol. , vol.306 , pp. F379-F388
    • DiRocco, D.P.1
  • 57
  • 58
    • 84942809864 scopus 로고    scopus 로고
    • Ischemia and reperfusion injury in renal transplantation: hemodynamic and immunological paradigms
    • Requião-Moura, L.R., De, M., Durão Junior, S., Carvalho De Matos, A.C., Pacheco-Silva, A., Ischemia and reperfusion injury in renal transplantation: hemodynamic and immunological paradigms. Einstein 13 (2015), 129–135.
    • (2015) Einstein , vol.13 , pp. 129-135
    • Requião-Moura, L.R.1    De, M.2    Durão Junior, S.3    Carvalho De Matos, A.C.4    Pacheco-Silva, A.5
  • 59
    • 77953790156 scopus 로고    scopus 로고
    • Honoring Clive McCay and 75 years of calorie restriction research
    • McDonald, R.B., Ramsey, J.J., Honoring Clive McCay and 75 years of calorie restriction research. J. Nutr. 140 (2010), 1205–1210.
    • (2010) J. Nutr. , vol.140 , pp. 1205-1210
    • McDonald, R.B.1    Ramsey, J.J.2
  • 60
    • 85014671397 scopus 로고    scopus 로고
    • Alleviation of senescence and epithelial-mesenchymal transition in aging kidney by short-term caloric restriction and caloric restriction mimetics via modulation of AMPK/mTOR signaling
    • Dong, D., et al. Alleviation of senescence and epithelial-mesenchymal transition in aging kidney by short-term caloric restriction and caloric restriction mimetics via modulation of AMPK/mTOR signaling. Oncotarget 8 (2017), 16109–16121.
    • (2017) Oncotarget , vol.8 , pp. 16109-16121
    • Dong, D.1
  • 61
    • 84900969225 scopus 로고    scopus 로고
    • Ink4a/Arf expression is a biomarker of aging
    • Krishnamurthy, J., et al. Ink4a/Arf expression is a biomarker of aging. J. Clin. Invest. 1114 (2004), 1299–1307.
    • (2004) J. Clin. Invest. , vol.1114 , pp. 1299-1307
    • Krishnamurthy, J.1
  • 62
    • 84870538183 scopus 로고    scopus 로고
    • Chronic caloric restriction preserves mitochondrial function in senescence without increasing mitochondrial biogenesis
    • Lanza, I.R., et al. Chronic caloric restriction preserves mitochondrial function in senescence without increasing mitochondrial biogenesis. Cell Metab. 16 (2012), 777–788.
    • (2012) Cell Metab. , vol.16 , pp. 777-788
    • Lanza, I.R.1
  • 63
    • 84891558933 scopus 로고    scopus 로고
    • Short-term calorie restriction protects against renal senescence of aged rats by increasing autophagic activity and reducing oxidative damage
    • Ning, Y.-C., et al. Short-term calorie restriction protects against renal senescence of aged rats by increasing autophagic activity and reducing oxidative damage. Mech. Ageing Dev. 134 (2013), 570–579.
    • (2013) Mech. Ageing Dev. , vol.134 , pp. 570-579
    • Ning, Y.-C.1
  • 64
    • 80053606380 scopus 로고    scopus 로고
    • Impact of caloric and dietary restriction regimens on markers of health and longevity in humans and animals: a summary of available findings
    • Trepanowski, J.F., Canale, R.E., Marshall, K.E., Kabir, M.M., Bloomer, R.J., Impact of caloric and dietary restriction regimens on markers of health and longevity in humans and animals: a summary of available findings. Nutr. J., 10, 2011, 107.
    • (2011) Nutr. J. , vol.10 , pp. 107
    • Trepanowski, J.F.1    Canale, R.E.2    Marshall, K.E.3    Kabir, M.M.4    Bloomer, R.J.5
  • 65
    • 78649969100 scopus 로고    scopus 로고
    • Preoperative fasting induced protection against renal ischemia/reperfusion injury is independent of ghrelin in mice
    • van Ginhoven, T.M., et al. Preoperative fasting induced protection against renal ischemia/reperfusion injury is independent of ghrelin in mice. Nutr. Res. 30 (2010), 865–869.
    • (2010) Nutr. Res. , vol.30 , pp. 865-869
    • van Ginhoven, T.M.1
  • 66
    • 84903527613 scopus 로고    scopus 로고
    • Preoperative fasting protects against renal ischemia-reperfusion injury in aged and overweight mice
    • Jongbloed, F., et al. Preoperative fasting protects against renal ischemia-reperfusion injury in aged and overweight mice. PLoS One, 9, 2014, e100853.
    • (2014) PLoS One , vol.9 , pp. e100853
    • Jongbloed, F.1
  • 67
    • 76249106732 scopus 로고    scopus 로고
    • Short-term dietary restriction and fasting precondition against ischemia reperfusion injury in mice
    • Mitchell, J.R., et al. Short-term dietary restriction and fasting precondition against ischemia reperfusion injury in mice. Aging Cell 9 (2010), 40–53.
    • (2010) Aging Cell , vol.9 , pp. 40-53
    • Mitchell, J.R.1
  • 68
    • 84949445465 scopus 로고    scopus 로고
    • Protection against renal ischemia–reperfusion injury through hormesis? Dietary intervention versus cold exposure
    • Shushimita, S., et al. Protection against renal ischemia–reperfusion injury through hormesis? Dietary intervention versus cold exposure. Life Sci. 144 (2016), 69–79.
    • (2016) Life Sci. , vol.144 , pp. 69-79
    • Shushimita, S.1
  • 69
    • 84886461893 scopus 로고    scopus 로고
    • Resveratrol and clinical trials: the crossroad from in vitro studies to human evidence
    • Tomé-Carneiro, J., et al. Resveratrol and clinical trials: the crossroad from in vitro studies to human evidence. Curr. Pharm. Des. 19 (2013), 6064–6093.
    • (2013) Curr. Pharm. Des. , vol.19 , pp. 6064-6093
    • Tomé-Carneiro, J.1
  • 70
    • 84975744759 scopus 로고    scopus 로고
    • Current understanding of metformin effect on the control of hyperglycemia in diabetes
    • An, H., He, L., Current understanding of metformin effect on the control of hyperglycemia in diabetes. J. Endocrinol. 228 (2016), R97–R106.
    • (2016) J. Endocrinol. , vol.228 , pp. R97-R106
    • An, H.1    He, L.2
  • 71
    • 84962547217 scopus 로고    scopus 로고
    • Metformin-mediated increase in DICER1 regulates microRNA expression and cellular senescence
    • Noren Hooten, N., et al. Metformin-mediated increase in DICER1 regulates microRNA expression and cellular senescence. Aging Cell 15 (2016), 572–581.
    • (2016) Aging Cell , vol.15 , pp. 572-581
    • Noren Hooten, N.1
  • 72
    • 84944075105 scopus 로고    scopus 로고
    • Metformin attenuated the inflammation after renal ischemia/reperfusion and suppressed apoptosis of renal tubular epithelial cell in rats
    • Wang, Z., et al. Metformin attenuated the inflammation after renal ischemia/reperfusion and suppressed apoptosis of renal tubular epithelial cell in rats. Acta Cir. Bras. 30 (2015), 617–623.
    • (2015) Acta Cir. Bras. , vol.30 , pp. 617-623
    • Wang, Z.1
  • 74
    • 84902579141 scopus 로고    scopus 로고
    • Nicotinamide mononucleotide, an intermediate of NAD+ synthesis, protects the heart from ischemia and reperfusion
    • Yamamoto, T., et al. Nicotinamide mononucleotide, an intermediate of NAD+ synthesis, protects the heart from ischemia and reperfusion. PLoS One, 9, 2014, e98972.
    • (2014) PLoS One , vol.9 , pp. e98972
    • Yamamoto, T.1
  • 75
    • 85016317809 scopus 로고    scopus 로고
    • + binding pocket that regulates protein–protein interactions during aging
    • + binding pocket that regulates protein–protein interactions during aging. Science (80-.) 355 (2017), 1312–1317.
    • (2017) Science (80-.) , vol.355 , pp. 1312-1317
    • Li, J.1
  • 76
    • 84902579141 scopus 로고    scopus 로고
    • Nicotinamide mononucleotide, an intermediate of NAD+ synthesis, protects the heart from ischemia and reperfusion
    • Yamamoto, T., et al. Nicotinamide mononucleotide, an intermediate of NAD+ synthesis, protects the heart from ischemia and reperfusion. PLoS One, 9, 2014, e98972.
    • (2014) PLoS One , vol.9 , pp. e98972
    • Yamamoto, T.1
  • 77
    • 84926523961 scopus 로고    scopus 로고
    • Senescence-associated inflammatory responses: aging and cancer perspectives
    • Lasry, A., Ben-Neriah, Y., Senescence-associated inflammatory responses: aging and cancer perspectives. Trends Immunol. 36 (2015), 217–228.
    • (2015) Trends Immunol. , vol.36 , pp. 217-228
    • Lasry, A.1    Ben-Neriah, Y.2
  • 78
    • 84881526073 scopus 로고    scopus 로고
    • A senescence-inflammatory switch from cancer-inhibitory to cancer-promoting mechanism
    • Pribluda, A., et al. A senescence-inflammatory switch from cancer-inhibitory to cancer-promoting mechanism. Cancer Cell 24 (2013), 242–256.
    • (2013) Cancer Cell , vol.24 , pp. 242-256
    • Pribluda, A.1
  • 79
    • 84867736667 scopus 로고    scopus 로고
    • Nuclear lamina defects cause ATM-dependent NF- B activation and link accelerated aging to a systemic inflammatory response
    • Osorio, F.G., et al. Nuclear lamina defects cause ATM-dependent NF- B activation and link accelerated aging to a systemic inflammatory response. Genes Dev. 26 (2012), 2311–2324.
    • (2012) Genes Dev. , vol.26 , pp. 2311-2324
    • Osorio, F.G.1
  • 80
    • 84966397603 scopus 로고    scopus 로고
    • JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age
    • Xu, M., et al. JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age. Proc. Natl. Acad. Sci. 112 (2015), E6301–E6310.
    • (2015) Proc. Natl. Acad. Sci. , vol.112 , pp. E6301-E6310
    • Xu, M.1
  • 81
    • 84975840886 scopus 로고    scopus 로고
    • Perspective Targeting the JAK/STAT pathway to fight age-related dysfunction
    • Xu, M., Tchkonia, T., Kirkland, J.L., Perspective Targeting the JAK/STAT pathway to fight age-related dysfunction. Pharmacol. Res. 111 (2016), 152–154.
    • (2016) Pharmacol. Res. , vol.111 , pp. 152-154
    • Xu, M.1    Tchkonia, T.2    Kirkland, J.L.3
  • 82
    • 81855173480 scopus 로고    scopus 로고
    • Sirolimus in solid organ transplantation: current therapies and new frontiers
    • Veroux, M., et al. Sirolimus in solid organ transplantation: current therapies and new frontiers. Immunotherapy 3 (2011), 1487–1497.
    • (2011) Immunotherapy , vol.3 , pp. 1487-1497
    • Veroux, M.1
  • 83
    • 80855138775 scopus 로고    scopus 로고
    • Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
    • Baker, D.J., et al. Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders. Nature 479 (2011), 232–236.
    • (2011) Nature , vol.479 , pp. 232-236
    • Baker, D.J.1
  • 84
    • 84958093401 scopus 로고    scopus 로고
    • Naturally occurring p16Ink4a-positive cells shorten healthy lifespan
    • Baker, D.J., et al. Naturally occurring p16Ink4a-positive cells shorten healthy lifespan. Nature 530 (2016), 184–189.
    • (2016) Nature , vol.530 , pp. 184-189
    • Baker, D.J.1
  • 85
    • 44849112219 scopus 로고    scopus 로고
    • ABT-263: a potent and orally bioavailable bcl-2 family inhibitor
    • Tse, C., et al. ABT-263: a potent and orally bioavailable bcl-2 family inhibitor. Cancer Res. 68 (2008), 3421–3428.
    • (2008) Cancer Res. , vol.68 , pp. 3421-3428
    • Tse, C.1
  • 86
    • 84954218515 scopus 로고    scopus 로고
    • Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice
    • Chang, J., et al. Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice. Nat. Med. 22 (2015), 78–83.
    • (2015) Nat. Med. , vol.22 , pp. 78-83
    • Chang, J.1
  • 87
    • 84963650460 scopus 로고    scopus 로고
    • Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL
    • Yosef, R., et al. Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL. Nat. Commun., 7, 2016, 11190.
    • (2016) Nat. Commun. , vol.7 , pp. 11190
    • Yosef, R.1
  • 88
    • 79952291173 scopus 로고    scopus 로고
    • Phase I study of Navitoclax (ABT-263), a novel Bcl-2 family inhibitor, in patients with small-cell lung cancer and other solid tumors
    • Gandhi, L., et al. Phase I study of Navitoclax (ABT-263), a novel Bcl-2 family inhibitor, in patients with small-cell lung cancer and other solid tumors. J. Clin. Oncol. 29 (2011), 909–916.
    • (2011) J. Clin. Oncol. , vol.29 , pp. 909-916
    • Gandhi, L.1
  • 89
    • 79959853252 scopus 로고    scopus 로고
    • Dasatinib – clinical trials and management of adverse events in imatinib resistant/intolerant chronic myeloid leukemia
    • Conchon, M., Freitas de, C.M.B.M., Rego, M.A. do C., Braga Junior, J.W.R., Dasatinib – clinical trials and management of adverse events in imatinib resistant/intolerant chronic myeloid leukemia. Rev. Bras. Hematol. Hemoter. 33 (2011), 131–139.
    • (2011) Rev. Bras. Hematol. Hemoter. , vol.33 , pp. 131-139
    • Conchon, M.1    Freitas de, C.M.B.M.2    Rego, M.A.D.C.3    Braga Junior, J.W.R.4
  • 90
    • 85016619121 scopus 로고    scopus 로고
    • New agents that target senescent cells: the flavone, fisetin, and the BCL-XL inhibitors, A1331852 and A1155463
    • Zhu, Y., et al. New agents that target senescent cells: the flavone, fisetin, and the BCL-XL inhibitors, A1331852 and A1155463. Aging (Albany NY) 9 (2017), 955–963.
    • (2017) Aging (Albany NY) , vol.9 , pp. 955-963
    • Zhu, Y.1
  • 91
    • 84969200609 scopus 로고    scopus 로고
    • Kidney-targeted drug delivery systems
    • Zhou, P., Sun, X., Zhang, Z., Kidney-targeted drug delivery systems. Acta Pharm. Sin. B 4 (2014), 37–42.
    • (2014) Acta Pharm. Sin. B , vol.4 , pp. 37-42
    • Zhou, P.1    Sun, X.2    Zhang, Z.3
  • 92
    • 85016052515 scopus 로고    scopus 로고
    • Targeted apoptosis of senescent cells restores tissue homeostasis in response to chemotoxicity and aging
    • Baar, M.P., et al. Targeted apoptosis of senescent cells restores tissue homeostasis in response to chemotoxicity and aging. Cell, 169, 2017.
    • (2017) Cell , vol.169
    • Baar, M.P.1
  • 93
    • 33749188883 scopus 로고    scopus 로고
    • FOXO4 transcriptional activity is regulated by monoubiquitination and USP7/HAUSP
    • van der Horst, A., et al. FOXO4 transcriptional activity is regulated by monoubiquitination and USP7/HAUSP. Nat. Cell Biol. 8 (2006), 1064–1073.
    • (2006) Nat. Cell Biol. , vol.8 , pp. 1064-1073
    • van der Horst, A.1
  • 94
    • 1542267804 scopus 로고    scopus 로고
    • Disruption of forkhead transcription factor (FOXO) family members in mice reveals their functional diversification
    • Hosaka, T., et al. Disruption of forkhead transcription factor (FOXO) family members in mice reveals their functional diversification. Proc. Natl. Acad. Sci. U. S. A. 101 (2004), 2975–2980.
    • (2004) Proc. Natl. Acad. Sci. U. S. A. , vol.101 , pp. 2975-2980
    • Hosaka, T.1
  • 95
    • 84959862066 scopus 로고    scopus 로고
    • Long live FOXO: unraveling the role of FOXO proteins in aging and longevity
    • Martins, R., Lithgow, G.J., Link, W., Long live FOXO: unraveling the role of FOXO proteins in aging and longevity. Aging Cell 15 (2016), 196–207.
    • (2016) Aging Cell , vol.15 , pp. 196-207
    • Martins, R.1    Lithgow, G.J.2    Link, W.3
  • 96
    • 84934281252 scopus 로고    scopus 로고
    • p53 in survival, death and metabolic health: a lifeguard with a licence to kill
    • Kruiswijk, F., Labuschagne, C.F., Vousden, K.H., p53 in survival, death and metabolic health: a lifeguard with a licence to kill. Nat. Rev. Mol. Cell Biol. 16 (2015), 393–405.
    • (2015) Nat. Rev. Mol. Cell Biol. , vol.16 , pp. 393-405
    • Kruiswijk, F.1    Labuschagne, C.F.2    Vousden, K.H.3
  • 97
    • 85021099106 scopus 로고    scopus 로고
    • Protein domain mimics as modulators of protein–Protein interactions
    • Sawyer, N., Watkins, A.M., Arora, P.S., Protein domain mimics as modulators of protein–Protein interactions. Acc. Chem. Res. 50 (2017), 1313–1322.
    • (2017) Acc. Chem. Res. , vol.50 , pp. 1313-1322
    • Sawyer, N.1    Watkins, A.M.2    Arora, P.S.3
  • 98
    • 84928243456 scopus 로고    scopus 로고
    • The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs
    • Zhu, Y., et al. The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs. Aging Cell 14 (2015), 644–658.
    • (2015) Aging Cell , vol.14 , pp. 644-658
    • Zhu, Y.1
  • 99
    • 84961223640 scopus 로고    scopus 로고
    • Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors
    • Zhu, Y., et al. Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors. Aging Cell, 15, 2016.
    • (2016) Aging Cell , vol.15
    • Zhu, Y.1
  • 100
    • 84986218395 scopus 로고    scopus 로고
    • Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice
    • Roos, C.M., et al. Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice. Aging Cell 15 (2016), 973–977.
    • (2016) Aging Cell , vol.15 , pp. 973-977
    • Roos, C.M.1
  • 101
    • 85013807598 scopus 로고    scopus 로고
    • Cellular senescence mediates fibrotic pulmonary disease
    • Schafer, M.J., et al. Cellular senescence mediates fibrotic pulmonary disease. Nat. Commun., 8, 2017, 14532.
    • (2017) Nat. Commun. , vol.8 , pp. 14532
    • Schafer, M.J.1
  • 102
    • 85028760817 scopus 로고    scopus 로고
    • Identification of HSP90 inhibitors as a novel class of senolytics
    • Fuhrmann-Stroissnigg, H., et al. Identification of HSP90 inhibitors as a novel class of senolytics. Nat. Commun., 8, 2017, 422.
    • (2017) Nat. Commun. , vol.8 , pp. 422
    • Fuhrmann-Stroissnigg, H.1
  • 103
    • 34447550488 scopus 로고    scopus 로고
    • Chaperoning cell death: a critical dual role for Hsp90 in small-cell lung cancer
    • Workman, P., Powers, M.V., Chaperoning cell death: a critical dual role for Hsp90 in small-cell lung cancer. Nat. Chem. Biol. 3 (2007), 455–457.
    • (2007) Nat. Chem. Biol. , vol.3 , pp. 455-457
    • Workman, P.1    Powers, M.V.2
  • 104
    • 84978612222 scopus 로고    scopus 로고
    • A phase 2 study of the hsp90 inhibitor AUY922 as treatment for patients with refractory gastrointestinal stromal tumors
    • Bendell, J.C., et al. A phase 2 study of the hsp90 inhibitor AUY922 as treatment for patients with refractory gastrointestinal stromal tumors. Cancer Invest. 34 (2016), 265–270.
    • (2016) Cancer Invest. , vol.34 , pp. 265-270
    • Bendell, J.C.1
  • 105
    • 84931069759 scopus 로고    scopus 로고
    • Phase 1/1B trial of the heat shock protein 90 inhibitor NVP-AUY922 as monotherapy or in combination with bortezomib in patients with relapsed or refractory multiple myeloma
    • Seggewiss-Bernhardt, R., et al. Phase 1/1B trial of the heat shock protein 90 inhibitor NVP-AUY922 as monotherapy or in combination with bortezomib in patients with relapsed or refractory multiple myeloma. Cancer 121 (2015), 2185–2192.
    • (2015) Cancer , vol.121 , pp. 2185-2192
    • Seggewiss-Bernhardt, R.1
  • 106
    • 84878971581 scopus 로고    scopus 로고
    • A multicenter phase II study of ganetespib monotherapy in patients with genotypically defined advanced non-small cell lung cancer
    • Socinski, M.A., et al. A multicenter phase II study of ganetespib monotherapy in patients with genotypically defined advanced non-small cell lung cancer. Clin. Cancer Rancer Res. 19 (2013), 3068–3077.
    • (2013) Clin. Cancer Rancer Res. , vol.19 , pp. 3068-3077
    • Socinski, M.A.1
  • 107
    • 0029999052 scopus 로고    scopus 로고
    • Phase I clinical trial of the flavonoid quercetin: pharmacokinetics and evidence for in vivo tyrosine kinase inhibition
    • Ferry, D.R., et al. Phase I clinical trial of the flavonoid quercetin: pharmacokinetics and evidence for in vivo tyrosine kinase inhibition. Clin. Cancer Res 2 (1996), 659–668.
    • (1996) Clin. Cancer Res , vol.2 , pp. 659-668
    • Ferry, D.R.1
  • 108
    • 84866759080 scopus 로고    scopus 로고
    • The effect of quercetin supplementation on selected markers of inflammation and oxidative stress
    • Askari, G., Ghiasvand, R., Feizi, A., Ghanadian, S.M., Karimian, J., The effect of quercetin supplementation on selected markers of inflammation and oxidative stress. J. Res. Med. Sci. 17 (2012), 637–641.
    • (2012) J. Res. Med. Sci. , vol.17 , pp. 637-641
    • Askari, G.1    Ghiasvand, R.2    Feizi, A.3    Ghanadian, S.M.4    Karimian, J.5
  • 109
    • 84944718190 scopus 로고    scopus 로고
    • Safety, efficacy, and pharmacokinetics of navitoclax (ABT-263) in combination with erlotinib in patients with advanced solid tumors
    • Tolcher, A.W., et al. Safety, efficacy, and pharmacokinetics of navitoclax (ABT-263) in combination with erlotinib in patients with advanced solid tumors. Cancer Chemother. Pharmacol. 76 (2015), 1025–1032.
    • (2015) Cancer Chemother. Pharmacol. , vol.76 , pp. 1025-1032
    • Tolcher, A.W.1
  • 110
    • 84930738714 scopus 로고    scopus 로고
    • A phase I safety and pharmacokinetic study of ABT-263 in combination with carboplatin/paclitaxel in the treatment of patients with solid tumors
    • Vlahovic, G., et al. A phase I safety and pharmacokinetic study of ABT-263 in combination with carboplatin/paclitaxel in the treatment of patients with solid tumors. Invest. New Drugs 32 (2014), 976–984.
    • (2014) Invest. New Drugs , vol.32 , pp. 976-984
    • Vlahovic, G.1
  • 111
    • 78649630259 scopus 로고    scopus 로고
    • Navitoclax, a targeted high-affinity inhibitor of BCL-2, in lymphoid malignancies: a phase 1 dose-escalation study of safety, pharmacokinetics, pharmacodynamics, and antitumour activity
    • Wilson, W.H., et al. Navitoclax, a targeted high-affinity inhibitor of BCL-2, in lymphoid malignancies: a phase 1 dose-escalation study of safety, pharmacokinetics, pharmacodynamics, and antitumour activity. Lancet Oncol. 11 (2010), 1149–1159.
    • (2010) Lancet Oncol. , vol.11 , pp. 1149-1159
    • Wilson, W.H.1
  • 114
    • 84870428597 scopus 로고    scopus 로고
    • Kidney transplantation and the ageing immune system
    • McKay, D., Jameson, J., Kidney transplantation and the ageing immune system. Nat. Rev. Nephrol. 8 (2012), 700–708.
    • (2012) Nat. Rev. Nephrol. , vol.8 , pp. 700-708
    • McKay, D.1    Jameson, J.2
  • 115
    • 84964059101 scopus 로고    scopus 로고
    • Pharmacogenetic aspects of the use of tacrolimus in renal transplantation: recent developments and ethnic considerations
    • Tang, J.T., et al. Pharmacogenetic aspects of the use of tacrolimus in renal transplantation: recent developments and ethnic considerations. Expert Opin. Drug Metab. Toxicol. 12 (2016), 555–565.
    • (2016) Expert Opin. Drug Metab. Toxicol. , vol.12 , pp. 555-565
    • Tang, J.T.1
  • 116
    • 84890458719 scopus 로고    scopus 로고
    • Immunosurveillance of senescent cells: the bright side of the senescence program
    • Sagiv, A., Krizhanovsky, V., Immunosurveillance of senescent cells: the bright side of the senescence program. Biogerontology 14 (2013), 617–628.
    • (2013) Biogerontology , vol.14 , pp. 617-628
    • Sagiv, A.1    Krizhanovsky, V.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.