Cellular senescence limits regenerative capacity and allograft survival

Journal of the American Society of Nephrology

Volumn 23, Issue 9, 2012, Pages 1467-1473

  Braun, Heidi ^a   Schmidt, Bernhard M W ^a   Raiss, Mirja ^a   Baisantry, Arpita ^a   Mircea Constantin, Dan ^a   Wang, Shijun ^b   Gross, Marie Luise ^c   Serrano, Manuel ^d   Schmitt, Roland ^a   Melk, Anette ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^c UNIVERSITY OF HEIDELBERG   (Germany)

^d Centro Nacional de Investigaciones Oncológicas   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 2A;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; FIBROSING ALVEOLITIS; GENE LOCUS; GRAFT SURVIVAL; KIDNEY FUNCTION; KIDNEY GRAFT; KIDNEY ISCHEMIA; KIDNEY TRANSPLANTATION; KIDNEY TUBULE CELL; MOUSE; NEPHRON; NONHUMAN; PRIORITY JOURNAL; REPERFUSION INJURY; WILD TYPE;

EID: 84866000795     PISSN: 10466673     EISSN: 15333450     Source Type: Journal    
DOI: 10.1681/ASN.2011100967     Document Type: Article

References (40)

1. Lamb KE, Lodhi S, Meier-Kriesche HU: Long-term renal allograft survival in the United States: A critical reappraisal. Am J Transplant 11: 450-462, 2011
2. Einecke G, Sis B, Reeve J, Mengel M, Campbell PM, Hidalgo LG, Kaplan B, Halloran PF: Antibody-mediated microcirculation injury is the major cause of late kidney transplant failure. Am J Transplant 9: 2520-2531, 2009
3. Nath KA: Tubulointerstitial changes as a major determinant in the progression of renal damage. Am J Kidney Dis 20: 1-17, 1992
4. Nankivell BJ, Borrows RJ, Fung CL, O'Connell PJ, Allen RD, Chapman JR: The natural history of chronic allograft nephropathy. N Engl J Med 349: 2326-2333, 2003 (Pubitemid 37509740)
5. Nakorchevsky A, Hewel JA, Kurian SM, Mondala TS, Campbell D, Head SR, Marsh CL, Yates JR 3rd, Salomon DR: Molecular mechanisms of chronic kidney transplant rejection via large-scale proteogenomic analysis of tissue biopsies. J Am Soc Nephrol 21: 362-373, 2010
6. Terasaki PI, Cecka JM, Gjertson DW: Impact analysis: A method for evaluating the impact of factors in clinical renal transplantation. In: Clinical Transplants, edited by Cecka JM, Terasaki PI, Los Angeles, CA, UCLA Tissue Typing Laboratory, 1998, pp 437-441
7. Gourishankar S, Hunsicker LG, Jhangri GS, Cockfield SM, Halloran PF: The stability of the glomerular filtration rate after renal transplantation is improving. J Am Soc Nephrol 14: 2387-2394, 2003 (Pubitemid 37052387)
8. Melk A: Senescence of renal cells: Molecular basis and clinical implications. Nephrol Dial Transplant 18: 2474-2478, 2003
9. Melk A, Halloran PF: Cell senescence and its implications for nephrology. J Am Soc Nephrol 12: 385-393, 2001 (Pubitemid 32116383)
10. Halloran PF, Melk A, Barth C: Rethinking chronic allograft nephropathy: The concept of accelerated senescence. J Am Soc Nephrol 10: 167-181, 1999 (Pubitemid 29034957)
11. Hayflick L, Moorhead PS: The serial cultivation of human diploid cell strains. Exp Cell Res 25: 585-621, 1961
12. Harley CB, Futcher AB, Greider CW: Telomeres shorten during ageing of human fibroblasts. Nature 345: 458-460, 1990
13. Martens UM, Chavez EA, Poon SSS, Schmoor C, Lansdorp PM: Accumulation of short telomeres in human fibroblasts prior to replicative senescence. Exp Cell Res 256: 291-299, 2000 (Pubitemid 30211191)
14. Bodnar AG, Ouellette M, Frolkis M, Holt SE, Chiu C-P, Morin GB, Harley CB, Shay JW, Lichtsteiner S, Wright WE: Extension of life-span by introduction of telomerase into normal human cells. Science 279: 349-352, 1998 (Pubitemid 28063364)
15. Wright WE, Shay JW: Telomere dynamics in cancer progression and prevention: Fundamental differences in human and mouse telomere biology. Nat Med 6: 849-851, 2000 (Pubitemid 30644735)
16. Weinberg RA: The retinoblastoma protein and cell cycle control. Cell 81: 323-330, 1995
17. Serrano M, Lee HW, Chin L, Cordon-Cardo C, Beach D, DePinho RA: Role of the INK4a locus in tumor suppression and cell mortality. Cell 85: 27-37, 1996 (Pubitemid 26116804)
18. Melk A, Schmidt BMW, Vongwiwatana A, Rayner DC, Halloran PF: Increased expression of senescence-associated cell cycle inhibitor p16INK4a in deteriorating renal transplants and diseased native kidney. Am J Transplant 5: 1375-1382, 2005 (Pubitemid 40839428)
19. Sis B, Tasanarong A, Khoshjou F, Dadras F, Solez K, Halloran PF: Accelerated expression of senescence associated cell cycle inhibitor p16INK4A in kidneys with glomerular disease. Kidney Int 71: 218-226, 2007 (Pubitemid 46160922)
20. Ferlicot S, Durrbach A, Bâ N, Desvaux D, Bedossa P, Paradis V: The role of replicative senescence in chronic allograft nephropathy. Hum Pathol 34: 924-928, 2003 (Pubitemid 37169623)
21. Chkhotua AB, Gabusi E, Altimari A, D'Errico A, Yakubovich M, Vienken J, Stefoni S, Chieco P, Yussim A, Grigioni WF: Increased expression of p16(INK4a) and p27(Kip1) cyclin-dependent kinase inhibitor genes in aging human kidney and chronic allograft nephropathy. Am J Kidney Dis 41: 1303-1313, 2003 (Pubitemid 36637987)
22. Szeto CC, Poon PY, Lai FM, Chow KM, Szeto CY, Li PK: Chromosomal telomere shortening of kidney cells in IgA nephropathy by the measurement of DNA in urinary sediment. Clin Nephrol 64: 337-342, 2005 (Pubitemid 41671884)
23. Joosten SA, van Ham V, Nolan CE, Borrias MC, Jardine AG, Shiels PG, van Kooten C, Paul LC: Telomere shortening and cellular senescence in a model of chronic renal allograft rejection. Am J Pathol 162: 1305-1312, 2003 (Pubitemid 36350674)
24. Westhoff JH, Schildhorn C, Jacobi C, Hömme M, Hartner A, Braun H, Kryzer C, Wang C, von Zglinicki T, Kränzlin B, Gretz N, Melk A: Telomere shortening reduces regenerative capacity after acute kidney injury. J Am Soc Nephrol 21: 327-336, 2010
25. Koppelstaetter C, Schratzberger G, Perco P, Hofer J, Mark W, Ollinger R, Oberbauer R, Schwarz C, Mitterbauer C, Kainz A, Karkoszka H, Wiecek A, Mayer B, Mayer G: Markers of cellular senescence in zero hour biopsies predict outcome in renal transplantation. Aging Cell 7: 491-497, 2008 (Pubitemid 351998609)
26. McGlynn LM, Stevenson K, Lamb K, Zino S, Brown M, Prina A, Kingsmore D, Shiels PG: Cellular senescence in pretransplant renal biopsies predicts postoperative organ function. Aging Cell 8: 45-51, 2009
27. Lawless C, Wang C, Jurk D, Merz A, Zglinicki T, Passos JF: Quantitative assessment of markers for cell senescence. Exp Gerontol 45: 772-778, 2010
28. Hochegger K, Koppelstaetter C, Tagwerker A, Huber JM, Heininger D, Mayer G, Rosenkranz AR: p21 and mTERT are novel markers for determining different ischemic time periods in renal ischemia-reperfusion injury. Am J Physiol Renal Physiol 292: F762-F768, 2007 (Pubitemid 46220544)
29. Chkhotua AB, Abendroth D, Froeba G, Schelzig H: Up-regulation of cell cycle regulatory genes after renal ischemia/reperfusion: Differential expression of p16(INK4a), p21(WAF1/CIP1) and p27(Kip1) cyclin-dependent kinase inhibitor genes depending on reperfusion time. Transpl Int 19: 72-77, 2006
30. Melk A, Schmidt BM, Braun H, Vongwiwatana A, Urmson J, Zhu LF, Rayner D, Halloran PF: Effects of donor age and cell senescence on kidney allograft survival. Am J Transplant 9: 114-123, 2009
31. Westhoff JH, Hilgers KF, Steinbach MP, Hartner A, Klanke B, Amann K, Melk A: Hypertension induces somatic cellular senescence in rats and humans by induction of cell cycle inhibitor p16INK4a. Hypertension 52: 123-129, 2008
32. Wolstein JM, Lee DH, Michaud J, Buot V, Stefanchik B, Plotkin MD: INK4a knockout mice exhibit increased fibrosis under normal conditions and in response to unilateral ureteral obstruction. Am J Physiol Renal Physiol 299: F1486-F1495, 2010
33. Humphreys BD, Valerius MT, Kobayashi A, Mugford JW, Soeung S, Duffield JS, McMahon AP, Bonventre JV: Intrinsic epithelial cells repair the kidney after injury. Cell Stem Cell 2: 284-291, 2008 (Pubitemid 351298594)
34. Bielesz B, Sirin Y, Si H, Niranjan T, Gruenwald A, Ahn S, Kato H, Pullman J, Gessler M, Haase VH, Susztak K: Epithelial Notch signaling regulates interstitial fibrosis development in the kidneys of mice and humans. J Clin Invest 120: 4040-4054, 2010
35. Yang L, Besschetnova TY, Brooks CR, Shah JV, Bonventre JV: Epithelial cell cycle arrest in G2/M mediates kidney fibrosis after injury. Nat Med 16: 535-543, 2010
36. Campisi J, Andersen JK, Kapahi P, Melov S: Cellular senescence: A link between cancer and age-related degenerative disease? Semin Cancer Biol 21: 354-359, 2011
37. Kuilman T, Michaloglou C, Mooi WJ, Peeper DS: The essence of senescence. Genes Dev 24: 2463-2479, 2010
38. Pitiyage GN, Slijepcevic P, Gabrani A, Chianea YG, Lim KP, Prime SS, Tilakaratne WM, Fortune F, Parkinson EK: Senescent mesenchymal cells accumulate in human fibrosis by a telomere-independent mechanism and ameliorate fibrosis through matrix metalloproteinases. J Pathol 223: 604-617, 2011
39. Krimpenfort P, Quon KC, Mooi WJ, Loonstra A, Berns A: Loss of p16Ink4a confers susceptibility to metastatic melanoma in mice. Nature 413: 83-86, 2001 (Pubitemid 32843492)
40. Keppler A, Gretz N, Schmidt R, Kloetzer HM, Groene HJ, Lelongt B, Meyer M, Sadick M, Pill J: Plasma creatinine determination in mice and rats: An enzymatic method compares favorably with a high-performance liquid chromatography assay. Kidney Int 71: 74-78, 2007 (Pubitemid 44967737)