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Volumn 33, Issue 2, 2011, Pages 131-139

Dasatinib - Clinical trials and management of adverse events in imatinib resistant/ intolerant chronic myeloid leukemia

Author keywords

BCR ABL positive drug therapy; Chronic; Clinical trial; Drug interactions; Drug resistance; Drug toxicity; Gastrointestinal tract drug effects; Interferonalpha administration dosage; Leukemia; Myelogenous; Neoplasm; Piperazines therapeutic use; Pyrimidines

Indexed keywords


EID: 79959853252     PISSN: 15168484     EISSN: None     Source Type: Journal    
DOI: 10.5581/1516-8484.20110034     Document Type: Review
Times cited : (25)

References (32)
  • 1
    • 0033614446 scopus 로고    scopus 로고
    • Chronic myeloid leukemia
    • Comment in: N Engl J Med. 1999;341(10):765
    • CL. Chronic myeloid leukemia. N Engl J Med. 1999; 340(17):1330-1340. Comment in: N Engl J Med. 1999;341(10):765.
    • (1999) N Engl J Med , vol.340 , Issue.17 , pp. 1330-1340
  • 2
    • 63449094749 scopus 로고    scopus 로고
    • Dasatinib treatment for Philadelphia chromosome-positive leukemias: Practical considerations
    • Khoury HJ, Guilhot F, Hughes TP, Kim DW, Cortes JE. Dasatinib treatment for Philadelphia chromosome-positive leukemias: practical considerations. Cancer. 2009;115(7):1381-1394.
    • (2009) Cancer , vol.115 , Issue.7 , pp. 1381-1394
    • Khoury, H.J.1    Guilhot, F.2    Hughes, T.P.3    Kim, D.W.4    Cortes, J.E.5
  • 4
    • 0037762632 scopus 로고    scopus 로고
    • Imatinib in patients with newly diagnosed chronic-phase myeloid leukemia
    • Suppl 2
    • O'Brien SG, Deininger MW. Imatinib in patients with newly diagnosed chronic-phase myeloid leukemia. Semin Hematol. 2003;40(2 Suppl 2):26-30.
    • (2003) Semin Hematol , vol.40 , Issue.2 , pp. 26-30
    • Óbrien, S.G.1    Deininger, M.W.2
  • 6
    • 0037434853 scopus 로고    scopus 로고
    • Clin Lab Haematol. 2005;27(6):416-417
    • N Engl J Med. 2003;348 (11):1048-1050. Clin Lab Haematol. 2005;27(6):416-417.
    • (2003) N Engl J Med , vol.348 , Issue.11 , pp. 1048-1050
  • 7
    • 33947224197 scopus 로고    scopus 로고
    • New insights into the pathophysiology of chronic myeloid leukemia and imatinib resistance
    • Kantarjian HM, Talpaz M, Giles F, OBrien S, Cortes J. New insights into the pathophysiology of chronic myeloid leukemia and imatinib resistance. Ann Intern Med. 2006;145(12):913-923.
    • (2006) Ann Intern Med , vol.145 , Issue.12 , pp. 913-923
    • Kantarjian, H.M.1    Talpaz, M.2    Giles, F.3    Obrien, S.4    Cortes, J.5
  • 8
    • 35448967331 scopus 로고    scopus 로고
    • Part I: Mechanisms of resistance to imatinib in chronic myeloid leukaemia
    • Apperley JF. Part I: mechanisms of resistance to imatinib in chronic myeloid leukaemia. Lancet Oncol. 2007;8(11):1018-1029.
    • (2007) Lancet Oncol , vol.8 , Issue.11 , pp. 1018-1029
    • Apperley, J.F.1
  • 9
    • 36549088120 scopus 로고    scopus 로고
    • Part II: Management of resistance to imatinib in chronic myeloid leukaemia
    • Apperley JF. Part II: management of resistance to imatinib in chronic myeloid leukaemia. Lancet Oncol. 2007;8(12):1116-1128.
    • (2007) Lancet Oncol , vol.8 , Issue.12 , pp. 1116-1128
    • Apperley, J.F.1
  • 10
    • 33745102555 scopus 로고    scopus 로고
    • Dasatinib in imatinib-resistant Philadelphia chromosomepositive leukemias
    • Comment in: N Engl J Med. 2006;354(24):2594-6. N Engl J Med. 2006;355(10):1062-3; author reply 1063-1064
    • Talpaz M, Shah NP, Kantarjian H, Donato N, Nicoll J, Paquette R, et al. Dasatinib in imatinib-resistant Philadelphia chromosomepositive leukemias. N Engl J Med. 2006;354(24):2531-2541. Comment in: N Engl J Med. 2006;354(24):2594-6. N Engl J Med. 2006;355(10):1062-3; author reply 1063-1064.
    • (2006) N Engl J Med , vol.354 , Issue.24 , pp. 2531-2541
    • Talpaz, M.1    Shah, N.P.2    Kantarjian, H.3    Donato, N.4    Nicoll, J.5    Paquette, R.6
  • 11
    • 33748416343 scopus 로고    scopus 로고
    • author reply 1063-1064
    • N Engl J Med. 2006; 355(10):1062; author reply 1063-1064.
    • (2006) N Engl J Med , vol.355 , Issue.10 , pp. 1062
  • 12
    • 34248324467 scopus 로고    scopus 로고
    • Dasatinib induces significant hematologic and cytogenetic responses in patients with imatinib-resistant or - intolerant chronic myeloid leukemia in accelerated phase
    • Guilhot F, Apperley J, Kim DW, Bullorsky EO, Baccarani M, Roboz GJ, et al. Dasatinib induces significant hematologic and cytogenetic responses in patients with imatinib-resistant or - intolerant chronic myeloid leukemia in accelerated phase. Blood. 2007;109(10):4143-50.
    • (2007) Blood , vol.109 , Issue.10 , pp. 4143-4150
    • Guilhot, F.1    Apperley, J.2    Kim, D.W.3    Bullorsky, E.O.4    Baccarani, M.5    Roboz, G.J.6
  • 13
    • 70249141675 scopus 로고    scopus 로고
    • Dasatinib in the treatment of chronic myeloid leukemia in accelerated phase after imatinib failure: The START a trial
    • Apperley JF, Cortes JE, Kim DW, Roy L, Roboz GJ, Rosti G, et al. Dasatinib in the treatment of chronic myeloid leukemia in accelerated phase after imatinib failure: the START a trial. J Clin Oncol. 2009;27(21):3472-9.
    • (2009) J Clin Oncol , vol.27 , Issue.21 , pp. 3472-3479
    • Apperley, J.F.1    Cortes, J.E.2    Kim, D.W.3    Roy, L.4    Roboz, G.J.5    Rosti, G.6
  • 14
    • 57849159300 scopus 로고    scopus 로고
    • Efficacy and safety of dasatinib in imatinib-resistant or -intolerant patients with chronic myeloid leukemia in blast phase
    • Cortes J, Kim DW, Raffoux E, Martinelli G, Ritchie E, Roy L, et al. Efficacy and safety of dasatinib in imatinib-resistant or -intolerant patients with chronic myeloid leukemia in blast phase. Leukemia. 2008;22(12):2176-2183.
    • (2008) Leukemia , vol.22 , Issue.12 , pp. 2176-2183
    • Cortes, J.1    Kim, D.W.2    Raffoux, E.3    Martinelli, G.4    Ritchie, E.5    Roy, L.6
  • 15
    • 33947280081 scopus 로고    scopus 로고
    • Dasatinib induces notable hematologic and cytogenetic responses in chronic-phase chronic myeloid leukemia after failure of imatinib therapy
    • Erratum in: Blood. 2007;110(5):1438
    • Hochhaus A, Kantarjian HM, Baccarani M, Lipton JH, Apperley JF, Druker BJ, et al. Dasatinib induces notable hematologic and cytogenetic responses in chronic-phase chronic myeloid leukemia after failure of imatinib therapy. Blood. 2007;109(6):2303-2309. Erratum in: Blood. 2007;110(5):1438.
    • (2007) Blood , vol.109 , Issue.6 , pp. 2303-2309
    • Hochhaus, A.1    Kantarjian, H.M.2    Baccarani, M.3    Lipton, J.H.4    Apperley, J.F.5    Druker, B.J.6
  • 16
    • 45149087139 scopus 로고    scopus 로고
    • Dasatinib induces durable cytogenetic responses in patients with chronic myelogenous leukemia in chronic phase with resistance or intolerance to imatinib
    • Hochhaus A, Baccarani M, Deininger M, Apperley JF, Lipton JH, Goldberg SL, et al. Dasatinib induces durable cytogenetic responses in patients with chronic myelogenous leukemia in chronic phase with resistance or intolerance to imatinib. Leukemia. 2008;22 (6):1200-1206.
    • (2008) Leukemia , Issue.6 , pp. 1200-1206
    • Hochhaus, A.1    Baccarani, M.2    Deininger, M.3    Apperley, J.F.4    Lipton, J.H.5    Goldberg, S.L.6
  • 17
    • 34249074686 scopus 로고    scopus 로고
    • Dasatinib or high-dose imatinib for chronicphase chronic myeloid leukemia after failure of first-line imatinib: A randomized phase 2 trial
    • Kantarjian H, Pasquini R, Hamerschlak N, Rousselot P, Holowiecki J, Jootar S, et al. Dasatinib or high-dose imatinib for chronicphase chronic myeloid leukemia after failure of first-line imatinib: a randomized phase 2 trial. Blood. 2007;109(12):5143-5150.
    • (2007) Blood , vol.109 , Issue.12 , pp. 5143-5150
    • Kantarjian, H.1    Pasquini, R.2    Hamerschlak, N.3    Rousselot, P.4    Holowiecki, J.5    Jootar, S.6
  • 18
    • 70149105272 scopus 로고    scopus 로고
    • Dasatinib or high-dose imatinib for chronicphase chronic myeloid leukemia resistant to imatinib at a dose of 400 to 600 milligrams daily: Two-year follow-up of a randomized phase 2 study (START-R)
    • Kantarjian H, Pasquini R, Levy V, Jootar S, Holowiecki J, Hamerschlak N, et al. Dasatinib or high-dose imatinib for chronicphase chronic myeloid leukemia resistant to imatinib at a dose of 400 to 600 milligrams daily: two-year follow-up of a randomized phase 2 study (START-R). Cancer. 2009;115(18):4136-4147.
    • (2009) Cancer , vol.115 , Issue.18 , pp. 4136-4147
    • Kantarjian, H.1    Pasquini, R.2    Levy, V.3    Jootar, S.4    Holowiecki, J.5    Hamerschlak, N.6
  • 19
    • 68349132224 scopus 로고    scopus 로고
    • Pharmacoeconomic benefits of dasatinib in the treatment of imatinib-resistant patients with chronic myelogenous leukemia
    • Taylor MJ, Scuffham PA. Pharmacoeconomic benefits of dasatinib in the treatment of imatinib-resistant patients with chronic myelogenous leukemia. Expert Rev Pharmacoecon Outcomes Res. 2009;9(2):117-21.
    • (2009) Expert Rev Pharmacoecon Outcomes Res , vol.9 , Issue.2 , pp. 117-121
    • Taylor, M.J.1    Scuffham, P.A.2
  • 20
    • 49249121723 scopus 로고    scopus 로고
    • Intermittent target inhibition with dasatinib 100 mg once daily preserves efficacy and improves tolerability in imatinib-resistant and -intolerant chronic-phase chronic myeloid leukemia
    • Comment in: Nat Clin Pract Oncol. 2009;6(2):68-9
    • Shah NP, Kantarjian HM, Kim DW, Rea D, Dorlhiac-Llacer PE, Milone JH, et al. Intermittent target inhibition with dasatinib 100 mg once daily preserves efficacy and improves tolerability in imatinib-resistant and -intolerant chronic-phase chronic myeloid leukemia. J Clin Oncol. 2008;26(19):3204-3212. Comment in: Nat Clin Pract Oncol. 2009;6(2):68-9.
    • (2008) J Clin Oncol , vol.26 , Issue.19 , pp. 3204-3212
    • Shah, N.P.1    Kantarjian, H.M.2    Kim, D.W.3    Rea, D.4    Dorlhiac-Llacer, P.E.5    Milone, J.H.6
  • 21
    • 79959816664 scopus 로고    scopus 로고
    • Dasatinib dose-optimization study in chronic phase chronic myeloid leukemia (CML-CP): Three-year follow-up with dasatinib 100 mg once daily and landmark analysis of cytogenetic response and progression-free survival (PFS) [abstract]. Paper presented at: 51° American Society of Hematology Annual Meeting
    • 7007. [cited 2010 Jan 12]. Available from
    • Stone RM, Kim DW, Kantarjian HM, Rousselot P, Hochhaus A, Dorlhiac-Llacer PE, et al. Dasatinib dose-optimization study in chronic phase chronic myeloid leukemia (CML-CP): three-year follow-up with dasatinib 100 mg once daily and landmark analysis of cytogenetic response and progression-free survival (PFS) [abstract]. Paper presented at: 51° American Society of Hematology Annual Meeting; 2009 Dec 5-8. New Orleans. J Clin Oncol. 2009;27(15s):7007. [cited 2010 Jan 12]. Available from: http://www.asco.org/ascov2/Meetings/Abstracts?&vmview=abst_detail_view&confID=65&abstractID=33899
    • (2009) New Orleans. J Clin Oncol , vol.27 , Issue.15
    • Stone, R.M.1    Kim, D.W.2    Kantarjian, H.M.3    Rousselot, P.4    Hochhaus, A.5    Dorlhiac-Llacer, P.E.6
  • 22
    • 67650607999 scopus 로고    scopus 로고
    • Phase 3 study of dasatinib 140 mg once daily versus 70 mg twice daily in patients with chronic myeloid leukemia in accelerated phase resistant or intolerant to imatinib: 15-month median follow-up
    • Comment in: Nat Rev Clin Oncol. 2009;6(12):680-2
    • Kantarjian H, Cortes J, Kim DW, Dorlhiac-Llacer P, Pasquini R, DiPersio J, et al. Phase 3 study of dasatinib 140 mg once daily versus 70 mg twice daily in patients with chronic myeloid leukemia in accelerated phase resistant or intolerant to imatinib: 15-month median follow-up. Blood. 2009;113(25):6322-6329. Comment in: Nat Rev Clin Oncol. 2009;6(12):680-2.
    • (2009) Blood , vol.113 , Issue.25 , pp. 6322-6329
    • Kantarjian, H.1    Cortes, J.2    Kim, D.W.3    Dorlhiac-Llacer, P.4    Pasquini, R.5    Dipersio, J.6
  • 23
    • 72449169564 scopus 로고    scopus 로고
    • The occurrence and management of fluid retention associated with TKI therapy in CML, with a focus on dasatinib
    • Masiello D, Gorospe G 3rd, Yang AS. The occurrence and management of fluid retention associated with TKI therapy in CML, with a focus on dasatinib. J Hematol Oncol. 2009;2:46.
    • (2009) J Hematol Oncol , vol.2 , pp. 46
    • Masiello, D.1    Gorospe III, G.2    Yang, A.S.3
  • 24
    • 79959824502 scopus 로고    scopus 로고
    • National Cancer Institute. Common Terminology Criteria for Adverse Events v3.0 (CTCAE) [Internet]. Washington, National Institutes of Health, [cited 2010 Apr 30]. Available from
    • National Cancer Institute. Common Terminology Criteria for Adverse Events v3.0 (CTCAE) [Internet]. Washington, National Institutes of Health; 2006. [cited 2010 Apr 30]. Available from: http://ctep.cancer.gov/protocolDevelopment/electronic_applications/docs/ctcaev3.pdf
    • (2006)
  • 25
    • 67749135477 scopus 로고    scopus 로고
    • New dosing schedules of dasatinib for CML and adverse event management
    • Wong SF. New dosing schedules of dasatinib for CML and adverse event management. J Hematol Oncol. 2009;2:10.
    • (2009) J Hematol Oncol , vol.2 , pp. 10
    • Wong, S.F.1
  • 26
    • 38949134552 scopus 로고    scopus 로고
    • Sprycel for chronic myeloid leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia resistant to or intolerant of imatinib mesylate
    • Brave M, Goodman V, Kaminskas E, Farrell A, Timmer W, Pope S, et al. Sprycel for chronic myeloid leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia resistant to or intolerant of imatinib mesylate. Clin Cancer Res. 2008;14 (2):352-9.
    • (2008) Clin Cancer Res , vol.14 , Issue.2 , pp. 352-359
    • Brave, M.1    Goodman, V.2    Kaminskas, E.3    Farrell, A.4    Timmer, W.5    Pope, S.6
  • 27
    • 33947356135 scopus 로고    scopus 로고
    • Dasatinib induces complete hematologic and cytogenetic responses in patients with imatinib-resistant or -intolerant chronic myeloid leukemia in blast crisis
    • Cortes J, Rousselot P, Kim DW, Ritchie E, Hamerschlak N, Coutre S, et al. Dasatinib induces complete hematologic and cytogenetic responses in patients with imatinib-resistant or -intolerant chronic myeloid leukemia in blast crisis. Blood. 2007;109(8):3207-13.
    • (2007) Blood , vol.109 , Issue.8 , pp. 3207-3213
    • Cortes, J.1    Rousselot, P.2    Kim, D.W.3    Ritchie, E.4    Hamerschlak, N.5    Coutre, S.6
  • 28
    • 79959841519 scopus 로고    scopus 로고
    • National Comprehensive Cancer Network. NCCN. Practice Guidelines in Oncology - v.2.2010 [database on the Internet]. Washington: NACCN, Washington: NACCN; 2010. [cited 2010 May 16]. Available from
    • National Comprehensive Cancer Network. NCCN. Practice Guidelines in Oncology - v.2.2010 [database on the Internet]. Washington: NACCN; 2010. [cited 2010 May 16]. Available from:http://www.nccn.org/professionals/physician_gls/f_guidelines.asp
    • (2010)
  • 29
    • 2642553015 scopus 로고    scopus 로고
    • Granulocyte-colony-stimulating factor(filgrastim) may overcome imatinib-induced neutropenia in patients with chronic-phase chronic myelogenous leukemia
    • Comment in: Cancer. 2005;103 (1):210-11
    • Quintas-Cardama A, Kantarjian H, O'Brien S, Garcia-Manero G, Rios MB, Talpaz M, et al. Granulocyte-colony-stimulating factor(filgrastim) may overcome imatinib-induced neutropenia in patients with chronic-phase chronic myelogenous leukemia. Cancer. 2004;100(12):2592-2597. Comment in: Cancer. 2005;103 (1):210-11.
    • (2004) Cancer , vol.100 , Issue.12
    • Quintas-Cardama, A.1    Kantarjian, H.2    O'Brien, S.3    Garcia-Manero, G.4    Rios, M.B.5    Talpaz, M.6
  • 30
    • 79959825570 scopus 로고    scopus 로고
    • Sprycel [Internet]. São Paulo: Bristol-Myers Squibb. [cited 2010 Apr 30]. Available from:
    • Sprycel [Internet]. São Paulo: Bristol-Myers Squibb. [cited 2010 Apr 30]. Available from: http://www4.anvisa.gov.br/base/visadoc/BM/BM[32257-1-0].PDF
  • 31
    • 43449091001 scopus 로고    scopus 로고
    • Pleural effusions in patients with chronic myeloid leukaemia treated with dasatinib may have an immunemediated pathogenesis
    • de Lavallade H, Punnialingam S, Milojkovic D, Bua M, Khorashad JS, Gabriel IH, et al. Pleural effusions in patients with chronic myeloid leukaemia treated with dasatinib may have an immunemediated pathogenesis. Br J Haematol. 2008;141(5):745-747.
    • (2008) Br J Haematol , vol.141 , Issue.5 , pp. 745-747
    • de Lavallade, H.1    Punnialingam, S.2    Milojkovic, D.3    Bua, M.4    Khorashad, J.S.5    Gabriel, I.H.6
  • 32
    • 34548523623 scopus 로고    scopus 로고
    • Pleural effusion in patients with chronic myelogenous leukemia treated with dasatinib after imatinib failure
    • Quintas-Cardama A, Kantarjian H, O ́Brien S, Borthakur G, Bruzzi J, Munden R, et al. Pleural effusion in patients with chronic myelogenous leukemia treated with dasatinib after imatinib failure. J Clin Oncol.2007;25(25):3908-3914.
    • (2007) J Clin Oncol , vol.25 , Issue.25 , pp. 3908-3914
    • Quintas-Cardama, A.1    Kantarjian, H.2    O'Brien, S.3    Borthakur, G.4    Bruzzi, J.5    Munden, R.6


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