메뉴 건너뛰기




Volumn 188, Issue 3, 2018, Pages 739-756

Discrete Pools of Oligomeric Amyloid-β Track with Spatial Learning Deficits in a Mouse Model of Alzheimer Amyloidosis

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; DODECYL SULFATE SODIUM;

EID: 85042331342     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.1016/j.ajpath.2017.11.011     Document Type: Article
Times cited : (15)

References (85)
  • 1
    • 84929051903 scopus 로고    scopus 로고
    • Toxic oligomer species of amyloid-beta in Alzheimer's disease, a timing issue
    • Lesne, S.E., Toxic oligomer species of amyloid-beta in Alzheimer's disease, a timing issue. Swiss Med Wkly, 144, 2014, w14021.
    • (2014) Swiss Med Wkly , vol.144 , pp. w14021
    • Lesne, S.E.1
  • 2
    • 84857642949 scopus 로고    scopus 로고
    • The toxic Abeta oligomer and Alzheimer's disease: an emperor in need of clothes
    • Benilova, I., Karran, E., De Strooper, B., The toxic Abeta oligomer and Alzheimer's disease: an emperor in need of clothes. Nat Neurosci 15 (2012), 349–357.
    • (2012) Nat Neurosci , vol.15 , pp. 349-357
    • Benilova, I.1    Karran, E.2    De Strooper, B.3
  • 3
    • 84860215480 scopus 로고    scopus 로고
    • Correlation of Alzheimer disease neuropathologic changes with cognitive status: a review of the literature
    • Nelson, P.T., Alafuzoff, I., Bigio, E.H., Bouras, C., Braak, H., Cairns, N.J., et al. Correlation of Alzheimer disease neuropathologic changes with cognitive status: a review of the literature. J Neuropathol Exp Neurol 71 (2012), 362–381.
    • (2012) J Neuropathol Exp Neurol , vol.71 , pp. 362-381
    • Nelson, P.T.1    Alafuzoff, I.2    Bigio, E.H.3    Bouras, C.4    Braak, H.5    Cairns, N.J.6
  • 4
    • 0014313861 scopus 로고
    • The association between quantitative measures of dementia and of senile change in the cerebral grey matter of elderly subjects
    • Blessed, G., Tomlinson, B.E., Roth, M., The association between quantitative measures of dementia and of senile change in the cerebral grey matter of elderly subjects. Br J Psychiatry 114 (1968), 797–811.
    • (1968) Br J Psychiatry , vol.114 , pp. 797-811
    • Blessed, G.1    Tomlinson, B.E.2    Roth, M.3
  • 5
    • 0025987048 scopus 로고
    • Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment
    • Terry, R.D., Masliah, E., Salmon, D.P., Butters, N., DeTeresa, R., Hill, R., Hansen, L.A., Katzman, R., Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment. Ann Neurol 30 (1991), 572–580.
    • (1991) Ann Neurol , vol.30 , pp. 572-580
    • Terry, R.D.1    Masliah, E.2    Salmon, D.P.3    Butters, N.4    DeTeresa, R.5    Hill, R.6    Hansen, L.A.7    Katzman, R.8
  • 6
    • 0026740795 scopus 로고
    • Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease
    • Arriagada, P.V., Growdon, J.H., Hedley-Whyte, E.T., Hyman, B.T., Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease. Neurology 42 (1992), 631–639.
    • (1992) Neurology , vol.42 , pp. 631-639
    • Arriagada, P.V.1    Growdon, J.H.2    Hedley-Whyte, E.T.3    Hyman, B.T.4
  • 7
    • 0027468235 scopus 로고
    • Neuropathological indexes of Alzheimer's disease in demented and nondemented persons aged 80 years and older
    • Berg, L., McKeel, D.W. Jr., Miller, J.P., Baty, J., Morris, J.C., Neuropathological indexes of Alzheimer's disease in demented and nondemented persons aged 80 years and older. Arch Neurol 50 (1993), 349–358.
    • (1993) Arch Neurol , vol.50 , pp. 349-358
    • Berg, L.1    McKeel, D.W.2    Miller, J.P.3    Baty, J.4    Morris, J.C.5
  • 8
    • 0025773225 scopus 로고
    • Neuritic pathology and dementia in Alzheimer's disease
    • McKee, A.C., Kosik, K.S., Kowall, N.W., Neuritic pathology and dementia in Alzheimer's disease. Ann Neurol 30 (1991), 156–165.
    • (1991) Ann Neurol , vol.30 , pp. 156-165
    • McKee, A.C.1    Kosik, K.S.2    Kowall, N.W.3
  • 11
    • 77953675879 scopus 로고    scopus 로고
    • Probing the biology of Alzheimer's disease in mice
    • Ashe, K.H., Zahs, K.R., Probing the biology of Alzheimer's disease in mice. Neuron 66 (2010), 631–645.
    • (2010) Neuron , vol.66 , pp. 631-645
    • Ashe, K.H.1    Zahs, K.R.2
  • 14
    • 84861606292 scopus 로고    scopus 로고
    • Effects of beta-amyloid accumulation on neural function during encoding across the adult lifespan
    • Kennedy, K.M., Rodrigue, K.M., Devous, M.D. Sr., Hebrank, A.C., Bischof, G.N., Park, D.C., Effects of beta-amyloid accumulation on neural function during encoding across the adult lifespan. Neuroimage 62 (2012), 1–8.
    • (2012) Neuroimage , vol.62 , pp. 1-8
    • Kennedy, K.M.1    Rodrigue, K.M.2    Devous, M.D.3    Hebrank, A.C.4    Bischof, G.N.5    Park, D.C.6
  • 16
    • 84895802685 scopus 로고    scopus 로고
    • Relation of neuropathology with cognitive decline among older persons without dementia
    • Boyle, P.A., Yu, L., Wilson, R.S., Schneider, J.A., Bennett, D.A., Relation of neuropathology with cognitive decline among older persons without dementia. Front Aging Neurosci, 5, 2013, 50.
    • (2013) Front Aging Neurosci , vol.5 , pp. 50
    • Boyle, P.A.1    Yu, L.2    Wilson, R.S.3    Schneider, J.A.4    Bennett, D.A.5
  • 21
    • 0029807527 scopus 로고    scopus 로고
    • Control of memory formation through regulated expression of a CaMKII transgene
    • Mayford, M., Bach, M.E., Huang, Y.Y., Wang, L., Hawkins, R.D., Kandel, E.R., Control of memory formation through regulated expression of a CaMKII transgene. Science 274 (1996), 1678–1683.
    • (1996) Science , vol.274 , pp. 1678-1683
    • Mayford, M.1    Bach, M.E.2    Huang, Y.Y.3    Wang, L.4    Hawkins, R.D.5    Kandel, E.R.6
  • 23
    • 84862264187 scopus 로고    scopus 로고
    • Transgenic APP expression during postnatal development causes persistent locomotor hyperactivity in the adult
    • Rodgers, S.P., Born, H.A., Das, P., Jankowsky, J.L., Transgenic APP expression during postnatal development causes persistent locomotor hyperactivity in the adult. Mol Neurodegener, 7, 2012, 28.
    • (2012) Mol Neurodegener , vol.7 , pp. 28
    • Rodgers, S.P.1    Born, H.A.2    Das, P.3    Jankowsky, J.L.4
  • 25
    • 30444454374 scopus 로고    scopus 로고
    • Morris water maze search strategy analysis in PDAPP mice before and after experimental traumatic brain injury
    • Brody, D.L., Holtzman, D.M., Morris water maze search strategy analysis in PDAPP mice before and after experimental traumatic brain injury. Exp Neurol 197 (2006), 330–340.
    • (2006) Exp Neurol , vol.197 , pp. 330-340
    • Brody, D.L.1    Holtzman, D.M.2
  • 26
    • 0025908356 scopus 로고
    • The Consortium to Establish a Registry for Alzheimer's Disease (CERAD), part II: standardization of the neuropathologic assessment of Alzheimer's disease
    • Mirra, S.S., Heyman, A., McKeel, D., Sumi, S.M., Crain, B.J., Brownlee, L.M., Vogel, F.S., Hughes, J.P., van Belle, G., Berg, L., The Consortium to Establish a Registry for Alzheimer's Disease (CERAD), part II: standardization of the neuropathologic assessment of Alzheimer's disease. Neurology 41 (1991), 479–486.
    • (1991) Neurology , vol.41 , pp. 479-486
    • Mirra, S.S.1    Heyman, A.2    McKeel, D.3    Sumi, S.M.4    Crain, B.J.5    Brownlee, L.M.6    Vogel, F.S.7    Hughes, J.P.8    van Belle, G.9    Berg, L.10
  • 27
    • 84934444742 scopus 로고    scopus 로고
    • Detecting abeta*56 oligomers in brain tissues
    • Sherman, M.A., Lesne, S.E., Detecting abeta*56 oligomers in brain tissues. Methods Mol Biol 670 (2011), 45–56.
    • (2011) Methods Mol Biol , vol.670 , pp. 45-56
    • Sherman, M.A.1    Lesne, S.E.2
  • 29
    • 0037088956 scopus 로고    scopus 로고
    • Behavioral characterization of the Tg2576 transgenic model of Alzheimer's disease through 19 months
    • King, D.L., Arendash, G.W., Behavioral characterization of the Tg2576 transgenic model of Alzheimer's disease through 19 months. Physiol Behav 75 (2002), 627–642.
    • (2002) Physiol Behav , vol.75 , pp. 627-642
    • King, D.L.1    Arendash, G.W.2
  • 30
    • 33845891619 scopus 로고    scopus 로고
    • Spatial learning and psychomotor performance of C57BL/6 mice: age sensitivity and reliability of individual differences
    • de Fiebre, N.C., Sumien, N., Forster, M.J., de Fiebre, C.M., Spatial learning and psychomotor performance of C57BL/6 mice: age sensitivity and reliability of individual differences. Age (Dordr) 28 (2006), 235–253.
    • (2006) Age (Dordr) , vol.28 , pp. 235-253
    • de Fiebre, N.C.1    Sumien, N.2    Forster, M.J.3    de Fiebre, C.M.4
  • 31
    • 35148819275 scopus 로고    scopus 로고
    • Age-dependent effects of environmental enrichment on spatial reference memory in male mice
    • Harburger, L.L., Lambert, T.J., Frick, K.M., Age-dependent effects of environmental enrichment on spatial reference memory in male mice. Behav Brain Res 185 (2007), 43–48.
    • (2007) Behav Brain Res , vol.185 , pp. 43-48
    • Harburger, L.L.1    Lambert, T.J.2    Frick, K.M.3
  • 32
    • 68049116930 scopus 로고    scopus 로고
    • The effects of aging on N-methyl-D-aspartate receptor subunits in the synaptic membrane and relationships to long-term spatial memory
    • Zhao, X., Rosenke, R., Kronemann, D., Brim, B., Das, S.R., Dunah, A.W., Magnusson, K.R., The effects of aging on N-methyl-D-aspartate receptor subunits in the synaptic membrane and relationships to long-term spatial memory. Neuroscience 162 (2009), 933–945.
    • (2009) Neuroscience , vol.162 , pp. 933-945
    • Zhao, X.1    Rosenke, R.2    Kronemann, D.3    Brim, B.4    Das, S.R.5    Dunah, A.W.6    Magnusson, K.R.7
  • 34
    • 0242668337 scopus 로고    scopus 로고
    • Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis
    • Kayed, R., Head, E., Thompson, J.L., McIntire, T.M., Milton, S.C., Cotman, C.W., Glabe, C.G., Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis. Science 300 (2003), 486–489.
    • (2003) Science , vol.300 , pp. 486-489
    • Kayed, R.1    Head, E.2    Thompson, J.L.3    McIntire, T.M.4    Milton, S.C.5    Cotman, C.W.6    Glabe, C.G.7
  • 38
    • 84869992747 scopus 로고    scopus 로고
    • The complex PrP(c)-Fyn couples human oligomeric Abeta with pathological tau changes in Alzheimer's disease
    • Larson, M., Sherman, M.A., Amar, F., Nuvolone, M., Schneider, J.A., Bennett, D.A., Aguzzi, A., Lesne, S.E., The complex PrP(c)-Fyn couples human oligomeric Abeta with pathological tau changes in Alzheimer's disease. J Neurosci 32 (2012), 16857–16871a.
    • (2012) J Neurosci , vol.32 , pp. 16857-16871a
    • Larson, M.1    Sherman, M.A.2    Amar, F.3    Nuvolone, M.4    Schneider, J.A.5    Bennett, D.A.6    Aguzzi, A.7    Lesne, S.E.8
  • 39
    • 84966708925 scopus 로고    scopus 로고
    • Amyloid-beta receptors: the good, the bad, and the prion protein
    • Jarosz-Griffiths, H.H., Noble, E., Rushworth, J.V., Hooper, N.M., Amyloid-beta receptors: the good, the bad, and the prion protein. J Biol Chem 291 (2016), 3174–3183.
    • (2016) J Biol Chem , vol.291 , pp. 3174-3183
    • Jarosz-Griffiths, H.H.1    Noble, E.2    Rushworth, J.V.3    Hooper, N.M.4
  • 40
    • 79951761390 scopus 로고    scopus 로고
    • The culprit behind amyloid beta peptide related neurotoxicity in Alzheimer's disease: oligomer size or conformation?
    • Broersen, K., Rousseau, F., Schymkowitz, J., The culprit behind amyloid beta peptide related neurotoxicity in Alzheimer's disease: oligomer size or conformation?. Alzheimers Res Ther, 2, 2010, 12.
    • (2010) Alzheimers Res Ther , vol.2 , pp. 12
    • Broersen, K.1    Rousseau, F.2    Schymkowitz, J.3
  • 42
    • 68149162581 scopus 로고    scopus 로고
    • Soluble fibrillar oligomer levels are elevated in Alzheimer's disease brain and correlate with cognitive dysfunction
    • Tomic, J.L., Pensalfini, A., Head, E., Glabe, C.G., Soluble fibrillar oligomer levels are elevated in Alzheimer's disease brain and correlate with cognitive dysfunction. Neurobiol Dis 35 (2009), 352–358.
    • (2009) Neurobiol Dis , vol.35 , pp. 352-358
    • Tomic, J.L.1    Pensalfini, A.2    Head, E.3    Glabe, C.G.4
  • 43
    • 84864497129 scopus 로고    scopus 로고
    • Vaccination with a non-human random sequence amyloid oligomer mimic results in improved cognitive function and reduced plaque deposition and micro hemorrhage in Tg2576 mice
    • Rasool, S., Albay, R. 3rd, Martinez-Coria, H., Breydo, L., Wu, J., Milton, S., Misra, S., Tran, A., Pensalfini, A., Laferla, F., Kayed, R., Glabe, C.G., Vaccination with a non-human random sequence amyloid oligomer mimic results in improved cognitive function and reduced plaque deposition and micro hemorrhage in Tg2576 mice. Mol Neurodegener, 7, 2012, 37.
    • (2012) Mol Neurodegener , vol.7 , pp. 37
    • Rasool, S.1    Albay, R.2    Martinez-Coria, H.3    Breydo, L.4    Wu, J.5    Milton, S.6    Misra, S.7    Tran, A.8    Pensalfini, A.9    Laferla, F.10    Kayed, R.11    Glabe, C.G.12
  • 44
    • 84885961431 scopus 로고    scopus 로고
    • Systemic vaccination with anti-oligomeric monoclonal antibodies improves cognitive function by reducing Abeta deposition and tau pathology in 3xTg-AD mice
    • Rasool, S., Martinez-Coria, H., Wu, J.W., LaFerla, F., Glabe, C.G., Systemic vaccination with anti-oligomeric monoclonal antibodies improves cognitive function by reducing Abeta deposition and tau pathology in 3xTg-AD mice. J Neurochem 126 (2013), 473–482.
    • (2013) J Neurochem , vol.126 , pp. 473-482
    • Rasool, S.1    Martinez-Coria, H.2    Wu, J.W.3    LaFerla, F.4    Glabe, C.G.5
  • 46
    • 85019231994 scopus 로고    scopus 로고
    • The amyloid-beta oligomer Abeta*56 induces specific alterations in neuronal signaling that lead to tau phosphorylation and aggregation
    • Amar, F., Sherman, M.A., Rush, T., Larson, M., Boyle, G., Chang, L., Gotz, J., Buisson, A., Lesne, S.E., The amyloid-beta oligomer Abeta*56 induces specific alterations in neuronal signaling that lead to tau phosphorylation and aggregation. Sci Signal, 10, 2017, eaal2021.
    • (2017) Sci Signal , vol.10 , pp. eaal2021
    • Amar, F.1    Sherman, M.A.2    Rush, T.3    Larson, M.4    Boyle, G.5    Chang, L.6    Gotz, J.7    Buisson, A.8    Lesne, S.E.9
  • 47
    • 70349973683 scopus 로고    scopus 로고
    • Biochemical and immunohistochemical analysis of an Alzheimer's disease mouse model reveals the presence of multiple cerebral Abeta assembly forms throughout life
    • Shankar, G.M., Leissring, M.A., Adame, A., Sun, X., Spooner, E., Masliah, E., Selkoe, D.J., Lemere, C.A., Walsh, D.M., Biochemical and immunohistochemical analysis of an Alzheimer's disease mouse model reveals the presence of multiple cerebral Abeta assembly forms throughout life. Neurobiol Dis 36 (2009), 293–302.
    • (2009) Neurobiol Dis , vol.36 , pp. 293-302
    • Shankar, G.M.1    Leissring, M.A.2    Adame, A.3    Sun, X.4    Spooner, E.5    Masliah, E.6    Selkoe, D.J.7    Lemere, C.A.8    Walsh, D.M.9
  • 48
    • 33144487701 scopus 로고    scopus 로고
    • Temporal profile of amyloid-beta (Abeta) oligomerization in an in vivo model of Alzheimer disease: a link between Abeta and tau pathology
    • Oddo, S., Caccamo, A., Tran, L., Lambert, M.P., Glabe, C.G., Klein, W.L., LaFerla, F.M., Temporal profile of amyloid-beta (Abeta) oligomerization in an in vivo model of Alzheimer disease: a link between Abeta and tau pathology. J Biol Chem 281 (2006), 1599–1604.
    • (2006) J Biol Chem , vol.281 , pp. 1599-1604
    • Oddo, S.1    Caccamo, A.2    Tran, L.3    Lambert, M.P.4    Glabe, C.G.5    Klein, W.L.6    LaFerla, F.M.7
  • 49
    • 84901029497 scopus 로고    scopus 로고
    • Using mice to model Alzheimer's dementia: an overview of the clinical disease and the preclinical behavioral changes in 10 mouse models
    • Webster, S.J., Bachstetter, A.D., Nelson, P.T., Schmitt, F.A., Van Eldik, L.J., Using mice to model Alzheimer's dementia: an overview of the clinical disease and the preclinical behavioral changes in 10 mouse models. Front Genet, 5, 2014, 88.
    • (2014) Front Genet , vol.5 , pp. 88
    • Webster, S.J.1    Bachstetter, A.D.2    Nelson, P.T.3    Schmitt, F.A.4    Van Eldik, L.J.5
  • 55
    • 84856353669 scopus 로고    scopus 로고
    • High-molecular weight Abeta oligomers and protofibrils are the predominant Abeta species in the native soluble protein fraction of the AD brain
    • Upadhaya, A.R., Lungrin, I., Yamaguchi, H., Fandrich, M., Thal, D.R., High-molecular weight Abeta oligomers and protofibrils are the predominant Abeta species in the native soluble protein fraction of the AD brain. J Cell Mol Med 16 (2012), 287–295.
    • (2012) J Cell Mol Med , vol.16 , pp. 287-295
    • Upadhaya, A.R.1    Lungrin, I.2    Yamaguchi, H.3    Fandrich, M.4    Thal, D.R.5
  • 56
    • 84865577637 scopus 로고    scopus 로고
    • Dispersible amyloid beta-protein oligomers, protofibrils, and fibrils represent diffusible but not soluble aggregates: their role in neurodegeneration in amyloid precursor protein (APP) transgenic mice
    • Rijal Upadhaya, A., Capetillo-Zarate, E., Kosterin, I., Abramowski, D., Kumar, S., Yamaguchi, H., Walter, J., Fandrich, M., Staufenbiel, M., Thal, D.R., Dispersible amyloid beta-protein oligomers, protofibrils, and fibrils represent diffusible but not soluble aggregates: their role in neurodegeneration in amyloid precursor protein (APP) transgenic mice. Neurobiol Aging 33 (2012), 2641–2660.
    • (2012) Neurobiol Aging , vol.33 , pp. 2641-2660
    • Rijal Upadhaya, A.1    Capetillo-Zarate, E.2    Kosterin, I.3    Abramowski, D.4    Kumar, S.5    Yamaguchi, H.6    Walter, J.7    Fandrich, M.8    Staufenbiel, M.9    Thal, D.R.10
  • 58
    • 84995912064 scopus 로고    scopus 로고
    • Preparation of pure populations of covalently stabilized amyloid beta-protein oligomers of specific sizes
    • Hayden, E.Y., Conovaloff, J.L., Mason, A., Bitan, G., Teplow, D.B., Preparation of pure populations of covalently stabilized amyloid beta-protein oligomers of specific sizes. Anal Biochem 518 (2017), 78–85.
    • (2017) Anal Biochem , vol.518 , pp. 78-85
    • Hayden, E.Y.1    Conovaloff, J.L.2    Mason, A.3    Bitan, G.4    Teplow, D.B.5
  • 61
    • 79955128215 scopus 로고    scopus 로고
    • Biology and pathophysiology of the amyloid precursor protein
    • Zheng, H., Koo, E.H., Biology and pathophysiology of the amyloid precursor protein. Mol Neurodegener, 6, 2011, 27.
    • (2011) Mol Neurodegener , vol.6 , pp. 27
    • Zheng, H.1    Koo, E.H.2
  • 62
    • 84922942705 scopus 로고    scopus 로고
    • Genomic mosaicism with increased amyloid precursor protein (APP) gene copy number in single neurons from sporadic Alzheimer's disease brains
    • Bushman, D.M., Kaeser, G.E., Siddoway, B., Westra, J.W., Rivera, R.R., Rehen, S.K., Yung, Y.C., Chun, J., Genomic mosaicism with increased amyloid precursor protein (APP) gene copy number in single neurons from sporadic Alzheimer's disease brains. Elife, 4, 2015, e05116.
    • (2015) Elife , vol.4 , pp. e05116
    • Bushman, D.M.1    Kaeser, G.E.2    Siddoway, B.3    Westra, J.W.4    Rivera, R.R.5    Rehen, S.K.6    Yung, Y.C.7    Chun, J.8
  • 64
    • 84958225958 scopus 로고    scopus 로고
    • The cellular phase of Alzheimer's disease
    • De Strooper, B., Karran, E., The cellular phase of Alzheimer's disease. Cell 164 (2016), 603–615.
    • (2016) Cell , vol.164 , pp. 603-615
    • De Strooper, B.1    Karran, E.2
  • 65
    • 84941600256 scopus 로고    scopus 로고
    • Neuroinflammatory changes negatively impact on LTP: a focus on IL-1beta
    • Lynch, M.A., Neuroinflammatory changes negatively impact on LTP: a focus on IL-1beta. Brain Res 1621 (2015), 197–204.
    • (2015) Brain Res , vol.1621 , pp. 197-204
    • Lynch, M.A.1
  • 66
    • 84876847878 scopus 로고    scopus 로고
    • Chemokines and the hippocampus: a new perspective on hippocampal plasticity and vulnerability
    • Williamson, L.L., Bilbo, S.D., Chemokines and the hippocampus: a new perspective on hippocampal plasticity and vulnerability. Brain Behav Immun 30 (2013), 186–194.
    • (2013) Brain Behav Immun , vol.30 , pp. 186-194
    • Williamson, L.L.1    Bilbo, S.D.2
  • 67
    • 78651412528 scopus 로고    scopus 로고
    • Immune modulation of learning, memory, neural plasticity and neurogenesis
    • Yirmiya, R., Goshen, I., Immune modulation of learning, memory, neural plasticity and neurogenesis. Brain Behav Immun 25 (2011), 181–213.
    • (2011) Brain Behav Immun , vol.25 , pp. 181-213
    • Yirmiya, R.1    Goshen, I.2
  • 71
    • 84936144528 scopus 로고    scopus 로고
    • The role of the tripartite glutamatergic synapse in the pathophysiology of Alzheimer's disease
    • Rudy, C.C., Hunsberger, H.C., Weitzner, D.S., Reed, M.N., The role of the tripartite glutamatergic synapse in the pathophysiology of Alzheimer's disease. Aging Dis 6 (2015), 131–148.
    • (2015) Aging Dis , vol.6 , pp. 131-148
    • Rudy, C.C.1    Hunsberger, H.C.2    Weitzner, D.S.3    Reed, M.N.4
  • 73
    • 84867603343 scopus 로고    scopus 로고
    • Cognitive reserve in ageing and Alzheimer's disease
    • Stern, Y., Cognitive reserve in ageing and Alzheimer's disease. Lancet Neurol 11 (2012), 1006–1012.
    • (2012) Lancet Neurol , vol.11 , pp. 1006-1012
    • Stern, Y.1
  • 76
    • 55949096820 scopus 로고    scopus 로고
    • Alzheimer disease and cognitive reserve: variation of education effect with carbon 11-labeled Pittsburgh Compound B uptake
    • Roe, C.M., Mintun, M.A., D'Angelo, G., Xiong, C., Grant, E.A., Morris, J.C., Alzheimer disease and cognitive reserve: variation of education effect with carbon 11-labeled Pittsburgh Compound B uptake. Arch Neurol 65 (2008), 1467–1471.
    • (2008) Arch Neurol , vol.65 , pp. 1467-1471
    • Roe, C.M.1    Mintun, M.A.2    D'Angelo, G.3    Xiong, C.4    Grant, E.A.5    Morris, J.C.6
  • 78
    • 39049170344 scopus 로고    scopus 로고
    • Cognitive reserve hypothesis: Pittsburgh Compound B and fluorodeoxyglucose positron emission tomography in relation to education in mild Alzheimer's disease
    • Kemppainen, N.M., Aalto, S., Karrasch, M., Nagren, K., Savisto, N., Oikonen, V., Viitanen, M., Parkkola, R., Rinne, J.O., Cognitive reserve hypothesis: Pittsburgh Compound B and fluorodeoxyglucose positron emission tomography in relation to education in mild Alzheimer's disease. Ann Neurol 63 (2008), 112–118.
    • (2008) Ann Neurol , vol.63 , pp. 112-118
    • Kemppainen, N.M.1    Aalto, S.2    Karrasch, M.3    Nagren, K.4    Savisto, N.5    Oikonen, V.6    Viitanen, M.7    Parkkola, R.8    Rinne, J.O.9
  • 79
    • 84905867828 scopus 로고    scopus 로고
    • Neuropsychological changes in asymptomatic persons with Alzheimer disease neuropathology
    • Monsell, S.E., Mock, C., Hassenstab, J., Roe, C.M., Cairns, N.J., Morris, J.C., Kukull, W., Neuropsychological changes in asymptomatic persons with Alzheimer disease neuropathology. Neurology 83 (2014), 434–440.
    • (2014) Neurology , vol.83 , pp. 434-440
    • Monsell, S.E.1    Mock, C.2    Hassenstab, J.3    Roe, C.M.4    Cairns, N.J.5    Morris, J.C.6    Kukull, W.7
  • 84
    • 84904258819 scopus 로고    scopus 로고
    • Impairments in experience-dependent scaling and stability of hippocampal place fields limit spatial learning in a mouse model of Alzheimer's disease
    • Zhao, R., Fowler, S.W., Chiang, A.C., Ji, D., Jankowsky, J.L., Impairments in experience-dependent scaling and stability of hippocampal place fields limit spatial learning in a mouse model of Alzheimer's disease. Hippocampus 24 (2014), 963–978.
    • (2014) Hippocampus , vol.24 , pp. 963-978
    • Zhao, R.1    Fowler, S.W.2    Chiang, A.C.3    Ji, D.4    Jankowsky, J.L.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.