Genetic suppression of transgenic APP rescues hypersynchronous network activity in a mouse model of alzeimer's disease

Journal of Neuroscience

Volumn 34, Issue 11, 2014, Pages 3826-3840

  Born, Heather A ^a   Kim, Ji Yoen ^a   Savjani, Ricky R ^a,b   Das, Pritam ^c   Dabaghian, Yuri A ^a,d   Guo, Qinxi ^a   Yoo, Jong W ^a   Schuler, Dorothy R ^e   Cirrito, John R ^e   Zheng, Hui ^a   Golde, Todd E ^f   Noebels, Jeffrey L ^a   Jankowsky, Joanna L ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b TEXAS A AND M HEALTH SCIENCE CENTER   (United States)

^c MAYO GRADUATE SCHOOL   (United States)

^d Rice University   (United States)

^e WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

Amyloid precursor protein; EEG; Epilepsy; Seizure; Sharp wave discharge; Transgene suppression

Indexed keywords

AMYLOID PRECURSOR PROTEIN; DOXYCYCLINE; GAMMA SECRETASE; N2 [2 (3, 5 DIFLUOROPHENYL) 2 HYDROXYACETYL] N1 (6, 7 DIHYDRO 5 METHYL 6 OXO 5H DIBENZ [B, D] AZEPIN 7 YL) ALANINAMIDE; UNCLASSIFIED DRUG; VESICULAR GLUTAMATE TRANSPORTER 1; VESICULAR INHIBITORY AMINO ACID TRANSPORTER;

ALZHEIMER DISEASE; AMYLOID PLAQUE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; ELECTROENCEPHALOGRAPHY; ENZYME LINKED IMMUNOSORBENT ASSAY; EPILEPTIC DISCHARGE; FEMALE; GENE EXPRESSION; GENE OVEREXPRESSION; GENE REPRESSION; HISTOLOGY; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; LOCOMOTION; MALE; MICRODIALYSIS; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SEIZURE; SENSITIVITY AND SPECIFICITY;

AMYLOID PRECURSOR PROTEIN; EEG; EPILEPSY; SEIZURE; SHARP WAVE DISCHARGE; TRANSGENE SUPPRESSION;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; CEREBRAL CORTEX; DISEASE MODELS, ANIMAL; ELECTROENCEPHALOGRAPHY; ENTROPY; FEMALE; GENE KNOCK-IN TECHNIQUES; HUMANS; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MODELS, NEUROLOGICAL; NEURAL INHIBITION; PRESENILIN-1; SEIZURES; SUPPRESSION, GENETIC; TRANSGENES;

EID: 84896764452     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.5171-13.2014     Document Type: Article

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